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Conserved domains on  [gi|518172316|ref|WP_019342524|]
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HIT domain-containing protein [Stutzerimonas stutzeri]

Protein Classification

HIT family protein( domain architecture ID 10472213)

HIT (Histidine triad) family protein, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), is part of a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides

CATH:  3.30.428.10
Gene Ontology:  GO:1904047
PubMed:  1472710|9323207|12504684|12119013
SCOP:  3000223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HIT pfam01230
HIT domain;
7-99 3.10e-24

HIT domain;


:

Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 3.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518172316    7 RLERDTLAVGDFPLCRLLLMNDANYPWFILVPRREEVSELFQLDPADQQLLWQEATMLAEILKDTFGAD-----KMNLAT 81
Cdd:pfam01230   1 RGEIPSTVVYEDDLVLAFLDIDPQAPGHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADgyrivINNGAH 80

                          90
                  ....*....|....*...
gi 518172316   82 LGNVVSQLHVHVVARRQD 99
Cdd:pfam01230  81 AGQSVPHLHIHVIPRRKH 98
 
Name Accession Description Interval E-value
HIT pfam01230
HIT domain;
7-99 3.10e-24

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 3.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518172316    7 RLERDTLAVGDFPLCRLLLMNDANYPWFILVPRREEVSELFQLDPADQQLLWQEATMLAEILKDTFGAD-----KMNLAT 81
Cdd:pfam01230   1 RGEIPSTVVYEDDLVLAFLDIDPQAPGHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADgyrivINNGAH 80

                          90
                  ....*....|....*...
gi 518172316   82 LGNVVSQLHVHVVARRQD 99
Cdd:pfam01230  81 AGQSVPHLHIHVIPRRKH 98
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 33-129 2.42e-14

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 64.97  E-value: 2.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518172316  33 WFILVPRREeVSELFQLDPADQQLLWQEATMLAEILKDTFGADKMNLATL-----GNVVSQLHVHVVARRQDDAAWPAPV 107
Cdd:COG0537   37 HTLVIPKRH-VASLFDLTPEELAELMRLAQKVAKALRKALGPDGFNLGINngeaaGQTVPHLHVHVIPRYEGDDNFMPVI 115

                         90       100
                 ....*....|....*....|..
gi 518172316 108 WgfqpaRPYNEAQLAVVRQKLK 129
Cdd:COG0537  116 G-----TKVDPEELEETARKLR 132
FHIT cd01275
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH ...
 25-101 3.79e-04

FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.


Pssm-ID: 238606 [Multi-domain]  Cd Length: 126  Bit Score: 38.04  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518172316  25 LMNdaNYPW----FILVPRREeVSELFQLDPADQQLLWQEATMLAEILKDTFGADKMNLA-----TLGNVVSQLHVHVVA 95
Cdd:cd01275   26 VVN--LYPYnpghVLVVPYRH-VPRLEDLTPEEIADLFKLVQLAMKALKVVYKPDGFNIGindgkAGGGIVPHVHIHIVP 102


                 ....*.
gi 518172316  96 RRQDDA 101
Cdd:cd01275  103 RWNGDT 108
 
Name Accession Description Interval E-value
HIT pfam01230
HIT domain;
7-99 3.10e-24

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 3.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518172316    7 RLERDTLAVGDFPLCRLLLMNDANYPWFILVPRREEVSELFQLDPADQQLLWQEATMLAEILKDTFGAD-----KMNLAT 81
Cdd:pfam01230   1 RGEIPSTVVYEDDLVLAFLDIDPQAPGHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADgyrivINNGAH 80

                          90
                  ....*....|....*...
gi 518172316   82 LGNVVSQLHVHVVARRQD 99
Cdd:pfam01230  81 AGQSVPHLHIHVIPRRKH 98
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 33-129 2.42e-14

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 64.97  E-value: 2.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518172316  33 WFILVPRREeVSELFQLDPADQQLLWQEATMLAEILKDTFGADKMNLATL-----GNVVSQLHVHVVARRQDDAAWPAPV 107
Cdd:COG0537   37 HTLVIPKRH-VASLFDLTPEELAELMRLAQKVAKALRKALGPDGFNLGINngeaaGQTVPHLHVHVIPRYEGDDNFMPVI 115

                         90       100
                 ....*....|....*....|..
gi 518172316 108 WgfqpaRPYNEAQLAVVRQKLK 129
Cdd:COG0537  116 G-----TKVDPEELEETARKLR 132
FHIT cd01275
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH ...
 25-101 3.79e-04

FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.


Pssm-ID: 238606 [Multi-domain]  Cd Length: 126  Bit Score: 38.04  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518172316  25 LMNdaNYPW----FILVPRREeVSELFQLDPADQQLLWQEATMLAEILKDTFGADKMNLA-----TLGNVVSQLHVHVVA 95
Cdd:cd01275   26 VVN--LYPYnpghVLVVPYRH-VPRLEDLTPEEIADLFKLVQLAMKALKVVYKPDGFNIGindgkAGGGIVPHVHIHIVP 102


                 ....*.
gi 518172316  96 RRQDDA 101
Cdd:cd01275  103 RWNGDT 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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