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Conserved domains on  [gi|518224989|ref|WP_019395197|]
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serine hydrolase [Priestia filamentosa]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
strep_PBP3 super family cl45725
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 11-425 8.18e-124

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


The actual alignment was detected with superfamily member NF038273:

Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 365.73  E-value: 8.18e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  11 IVASLLVLQLWIVAPIAHAQEVDkpnLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDT 90
Cdd:NF038273   3 LILLLLLLLAFFLATTVSADDFD---VAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  91 YEPSDYAYKISQNLSLSNVPLAKgEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNA 170
Cdd:NF038273  80 VKISDYPYELTTNYEISNVPLDA-RKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 171 TGLSNSDLQGMQPKGTKASDENLVSARSTAKLASHLINDYPEVLETSKLKEKTFhkgknGETQMKSWNWMLPGLvyEYEK 250
Cdd:NF038273 159 SGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF-----AGTTIYSYNYMLKGM--PYYR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 251 AEVDGLKTGSTDFAGYCFTGTAEKDGARYITVVMDAkDHGQESYEARFSETAKLLDYAFDNFEVKTLHPAGYTLKE-KVK 329
Cdd:NF038273 232 EGVDGLKTGTTEKAGASFVATSVENGMRVITVVLNA-DNADEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKDsKLP 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 330 VAKGNEKEAKVTTKEPLKVVVEKGKNAKKAVEtelVVNEKKlnndgKLIAPIEKGEEVGYINVKYKDD-QFGYLttdgDN 408
Cdd:NF038273 311 VIDGKKKTVSAVAKKDLTVIQKIGTDSKPSVK---FTPKKK-----ELTAPIKKGQVVGKATFKDKDLiGKGYL----GE 378

                        410
                 ....*....|....*..
gi 518224989 409 QSGVPIVMKEDIDKANW 425
Cdd:NF038273 379 PPSVELVAKKDVKKSFF 395
 
Name Accession Description Interval E-value
strep_PBP3 NF038273
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 11-425 8.18e-124

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 365.73  E-value: 8.18e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  11 IVASLLVLQLWIVAPIAHAQEVDkpnLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDT 90
Cdd:NF038273   3 LILLLLLLLAFFLATTVSADDFD---VAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  91 YEPSDYAYKISQNLSLSNVPLAKgEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNA 170
Cdd:NF038273  80 VKISDYPYELTTNYEISNVPLDA-RKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 171 TGLSNSDLQGMQPKGTKASDENLVSARSTAKLASHLINDYPEVLETSKLKEKTFhkgknGETQMKSWNWMLPGLvyEYEK 250
Cdd:NF038273 159 SGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF-----AGTTIYSYNYMLKGM--PYYR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 251 AEVDGLKTGSTDFAGYCFTGTAEKDGARYITVVMDAkDHGQESYEARFSETAKLLDYAFDNFEVKTLHPAGYTLKE-KVK 329
Cdd:NF038273 232 EGVDGLKTGTTEKAGASFVATSVENGMRVITVVLNA-DNADEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKDsKLP 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 330 VAKGNEKEAKVTTKEPLKVVVEKGKNAKKAVEtelVVNEKKlnndgKLIAPIEKGEEVGYINVKYKDD-QFGYLttdgDN 408
Cdd:NF038273 311 VIDGKKKTVSAVAKKDLTVIQKIGTDSKPSVK---FTPKKK-----ELTAPIKKGQVVGKATFKDKDLiGKGYL----GE 378

                        410
                 ....*....|....*..
gi 518224989 409 QSGVPIVMKEDIDKANW 425
Cdd:NF038273 379 PPSVELVAKKDVKKSFF 395
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
14-427 5.16e-111

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 330.26  E-value: 5.16e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  14 SLLVLQLWIVAPIAHAQEVDKPNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDTYEP 93
Cdd:COG1686    3 KLLLLALLLLLAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  94 SDYAYKISqnlsLSNVPLAKGEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNATGL 173
Cdd:COG1686   83 SEEAARTG----GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 174 SNsdlqgmqpkgtkasDENLVSARSTAKLASHLINDYPEVLETSKLKEKTFHKGKNgeTQMKSWNWMLpglvYEYEKaeV 253
Cdd:COG1686  159 PD--------------PGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRG--ITLRNTNRLL----GRYPG--V 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 254 DGLKTGSTDFAGYCFTGTAEKDGARYITVVMDAKdhgqeSYEARFSETAKLLDYAFdnfevktlhPAGYTLKEKVKVakg 333
Cdd:COG1686  217 DGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAP-----SEKARFADAAKLLDYGF---------PKGEALKAEVVL--- 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 334 nekeakvttkeplkvvvekgknakkavetelvvnekklnnDGKLIAPIEKGEEVGYINVKYKDDQFGylttdgdnqsGVP 413
Cdd:COG1686  280 ----------------------------------------DGPLKAPVKKGQVVGTLVVTLDGKTIA----------EVP 309

                        410
                 ....*....|....
gi 518224989 414 IVMKEDIDKANWFS 427
Cdd:COG1686  310 LVAAEDVEKAGFFS 323
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
35-287 1.29e-86

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 264.63  E-value: 1.29e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   35 PNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDTYEPSDYAYKISQNLSlSNVPLAKG 114
Cdd:pfam00768   4 PEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGS-SNIFLKPG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  115 EKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNATGLSNsdlqgmqpkgtkasDENLV 194
Cdd:pfam00768  83 SQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA--------------HGQYS 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  195 SARSTAKLASHLINDYPEVLETSKLKEKTFhkgkngeTQMKSWNWMLPGLVYEYEKAEVDGLKTGSTDFAGYCFTGTAEK 274
Cdd:pfam00768 149 SARDMAILAKALIKDLPEELSITKEKSFTF-------RGINKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATK 221

                         250
                  ....*....|...
gi 518224989  275 DGARYITVVMDAK 287
Cdd:pfam00768 222 GGMRLISVVMGAF 234
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
20-452 8.31e-45

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 160.93  E-value: 8.31e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  20 LWIVAPIAHAQE--VDKPNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDTYEPSDYA 97
Cdd:PRK10001  18 LFLFAPTAFAAEqtVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  98 YKISQ-NLSLSNVPLAK-GEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNATGLsn 175
Cdd:PRK10001  98 WATGNpALRGSSVMFLKpGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGL-- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 176 sDLQGmqpkgtkasdeNLVSARSTAKLASHLINDYPEVLETSKLKEKTFHKGKNGETQMKSWNWMLpglvyeyekaEVDG 255
Cdd:PRK10001 176 -DAPG-----------QFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNL----------NVDG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 256 LKTGSTDFAGYCFTGTAEKDGARYITVVMDAKDHGqesyeARFSETAKLLDYAFDNFEVKT-LHPAGYTLKEKVKVakGN 334
Cdd:PRK10001 234 MKTGTTAGAGYNLVASATQGDMRLISVVLGAKTDR-----IRFNESEKLLTWGFRFFETVTpIKPDATFVTQRVWF--GD 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 335 EKEAKVTTKEPLKVVVEKG--KNAKKAVETelvvnekklnNDGKLIAPIEKGEEVGYINVKYkddqfgylttDGDNQSGV 412
Cdd:PRK10001 307 KSEVNLGAGEAGSVTIPRGqlKNLKASYTL----------TEPQLTAPLKKGQVVGTIDFQL----------NGKSIEQR 366

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 518224989 413 PIVMKEDIDKanwfslmfrsiGDFFADMWTSAANMVKGWF 452
Cdd:PRK10001 367 PLIVMENVEE-----------GGFFSRMWDFVMMKFHQWF 395
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 312-422 1.51e-13

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 66.09  E-value: 1.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   312 FEVKTLHPAGYTLKeKVKVAKGNEKEAKVTTKEPLKVVVEKGKNAKkaVETELVVNEKKLNndgkliAPIEKGEEVGYIn 391
Cdd:smart00936   1 FETVKLYKKGQVVG-TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKK--LKAKVVLDKPELE------APIKKGQVVGTL- 70

                           90       100       110
                   ....*....|....*....|....*....|.
gi 518224989   392 vkykddqfgYLTTDGDNQSGVPIVMKEDIDK 422
Cdd:smart00936  71 ---------VVTLDGKLIGEVPLVALEDVEK 92
 
Name Accession Description Interval E-value
strep_PBP3 NF038273
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ...
 11-425 8.18e-124

streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.


Pssm-ID: 468443 [Multi-domain]  Cd Length: 407  Bit Score: 365.73  E-value: 8.18e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  11 IVASLLVLQLWIVAPIAHAQEVDkpnLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDT 90
Cdd:NF038273   3 LILLLLLLLAFFLATTVSADDFD---VAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  91 YEPSDYAYKISQNLSLSNVPLAKgEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNA 170
Cdd:NF038273  80 VKISDYPYELTTNYEISNVPLDA-RKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 171 TGLSNSDLQGMQPKGTKASDENLVSARSTAKLASHLINDYPEVLETSKLKEKTFhkgknGETQMKSWNWMLPGLvyEYEK 250
Cdd:NF038273 159 SGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF-----AGTTIYSYNYMLKGM--PYYR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 251 AEVDGLKTGSTDFAGYCFTGTAEKDGARYITVVMDAkDHGQESYEARFSETAKLLDYAFDNFEVKTLHPAGYTLKE-KVK 329
Cdd:NF038273 232 EGVDGLKTGTTEKAGASFVATSVENGMRVITVVLNA-DNADEDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKDsKLP 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 330 VAKGNEKEAKVTTKEPLKVVVEKGKNAKKAVEtelVVNEKKlnndgKLIAPIEKGEEVGYINVKYKDD-QFGYLttdgDN 408
Cdd:NF038273 311 VIDGKKKTVSAVAKKDLTVIQKIGTDSKPSVK---FTPKKK-----ELTAPIKKGQVVGKATFKDKDLiGKGYL----GE 378

                        410
                 ....*....|....*..
gi 518224989 409 QSGVPIVMKEDIDKANW 425
Cdd:NF038273 379 PPSVELVAKKDVKKSFF 395
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
14-427 5.16e-111

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 330.26  E-value: 5.16e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  14 SLLVLQLWIVAPIAHAQEVDKPNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDTYEP 93
Cdd:COG1686    3 KLLLLALLLLLAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  94 SDYAYKISqnlsLSNVPLAKGEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNATGL 173
Cdd:COG1686   83 SEEAARTG----GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 174 SNsdlqgmqpkgtkasDENLVSARSTAKLASHLINDYPEVLETSKLKEKTFHKGKNgeTQMKSWNWMLpglvYEYEKaeV 253
Cdd:COG1686  159 PD--------------PGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRG--ITLRNTNRLL----GRYPG--V 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 254 DGLKTGSTDFAGYCFTGTAEKDGARYITVVMDAKdhgqeSYEARFSETAKLLDYAFdnfevktlhPAGYTLKEKVKVakg 333
Cdd:COG1686  217 DGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAP-----SEKARFADAAKLLDYGF---------PKGEALKAEVVL--- 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 334 nekeakvttkeplkvvvekgknakkavetelvvnekklnnDGKLIAPIEKGEEVGYINVKYKDDQFGylttdgdnqsGVP 413
Cdd:COG1686  280 ----------------------------------------DGPLKAPVKKGQVVGTLVVTLDGKTIA----------EVP 309

                        410
                 ....*....|....
gi 518224989 414 IVMKEDIDKANWFS 427
Cdd:COG1686  310 LVAAEDVEKAGFFS 323
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
35-287 1.29e-86

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 264.63  E-value: 1.29e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   35 PNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDTYEPSDYAYKISQNLSlSNVPLAKG 114
Cdd:pfam00768   4 PEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGS-SNIFLKPG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  115 EKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNATGLSNsdlqgmqpkgtkasDENLV 194
Cdd:pfam00768  83 SQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA--------------HGQYS 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  195 SARSTAKLASHLINDYPEVLETSKLKEKTFhkgkngeTQMKSWNWMLPGLVYEYEKAEVDGLKTGSTDFAGYCFTGTAEK 274
Cdd:pfam00768 149 SARDMAILAKALIKDLPEELSITKEKSFTF-------RGINKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATK 221

                         250
                  ....*....|...
gi 518224989  275 DGARYITVVMDAK 287
Cdd:pfam00768 222 GGMRLISVVMGAF 234
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
20-452 8.31e-45

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 160.93  E-value: 8.31e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  20 LWIVAPIAHAQE--VDKPNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDDTYEPSDYA 97
Cdd:PRK10001  18 LFLFAPTAFAAEqtVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  98 YKISQ-NLSLSNVPLAK-GEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQELGMKDAKFVNATGLsn 175
Cdd:PRK10001  98 WATGNpALRGSSVMFLKpGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGL-- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 176 sDLQGmqpkgtkasdeNLVSARSTAKLASHLINDYPEVLETSKLKEKTFHKGKNGETQMKSWNWMLpglvyeyekaEVDG 255
Cdd:PRK10001 176 -DAPG-----------QFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNL----------NVDG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 256 LKTGSTDFAGYCFTGTAEKDGARYITVVMDAKDHGqesyeARFSETAKLLDYAFDNFEVKT-LHPAGYTLKEKVKVakGN 334
Cdd:PRK10001 234 MKTGTTAGAGYNLVASATQGDMRLISVVLGAKTDR-----IRFNESEKLLTWGFRFFETVTpIKPDATFVTQRVWF--GD 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 335 EKEAKVTTKEPLKVVVEKG--KNAKKAVETelvvnekklnNDGKLIAPIEKGEEVGYINVKYkddqfgylttDGDNQSGV 412
Cdd:PRK10001 307 KSEVNLGAGEAGSVTIPRGqlKNLKASYTL----------TEPQLTAPLKKGQVVGTIDFQL----------NGKSIEQR 366

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 518224989 413 PIVMKEDIDKanwfslmfrsiGDFFADMWTSAANMVKGWF 452
Cdd:PRK10001 367 PLIVMENVEE-----------GGFFSRMWDFVMMKFHQWF 395
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 2-437 1.37e-37

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 141.53  E-value: 1.37e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   2 KLTQRLFVGIVASLLVLQlwivapIAHAQEVD-------KPNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEY 74
Cdd:PRK10793   8 RIMKRLALTTALCTAFIS------AAHADDLNiktmipgVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  75 LLLENIHEGKLSWDDTYEPSDYAYK----ISQNLSLsnVPLAKGEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFV 150
Cdd:PRK10793  82 VIGQAMKAGKFKETDLVTVGNDAWAtgnpVFKGSSL--MFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 151 KMMNEKAQELGMKDAKFVNATGLsnsDLQGmqpkgtkasdeNLVSARSTAKLASHLINDYPEVLETSKLKEKTFhkgkNG 230
Cdd:PRK10793 160 GLMNSYVNALGLKNTHFQTVHGL---DADG-----------QYSSARDMALIGQALIRDVPNEYAIYKEKEFTF----NG 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 231 ETQMKSwnwmlPGLVYEyEKAEVDGLKTGSTDFAGYCFTGTAEKDGARYITVVMdakdhGQESYEARFSETAKLLDYAFD 310
Cdd:PRK10793 222 IRQLNR-----NGLLWD-NSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVM-----GGRTFKGRETESKKLLTWGFR 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 311 NFEVKTLHPAGYTLKEKvKVAKGNEKEAKVTTKEPLKVVVEKGKnaKKAVETELVVNEKKLNndgkliAPIEKGEEVGYI 390
Cdd:PRK10793 291 FFETVNPLKVGKEFASE-PVWFGDSDRASLGVDKDVYLTIPRGR--MKDLKASYVLNTSELH------APLQKNQVVGTI 361

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 518224989 391 NVKYkddqfgylttDGDNQSGVPIVMKEDIDKANWFSLMFRSIGDFF 437
Cdd:PRK10793 362 NFQL----------DGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMF 398
dacD PRK11397
serine-type D-Ala-D-Ala carboxypeptidase DacD;
3-437 5.55e-37

serine-type D-Ala-D-Ala carboxypeptidase DacD;


Pssm-ID: 183117 [Multi-domain]  Cd Length: 388  Bit Score: 139.57  E-value: 5.55e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   3 LTQRLFvgIVASLLVLQLwivAPIAHAQEVD----KPNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLE 78
Cdd:PRK11397   1 LKRRLI--IAASLFAFNL---SSAFAAENIPfspqPPAIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  79 NIHEGKLSWDDTYEPSDYAYK----ISQNLSLsnVPLAKGEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMN 154
Cdd:PRK11397  76 AIDSHRITPDDIVTVGRDAWAkdnpVFVGSSL--MFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMN 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 155 EKAQELGMKDAKFVNATGLsnsDLQGMQPkgtkasdenlvSARSTAKLASHLINDYPEVLETSKLKEKTFhkgkNGETQM 234
Cdd:PRK11397 154 NYVEKLHLKDTHFETVHGL---DAPGQHS-----------SAYDLAVLSRAIIHGEPEFYHMYSEKSLTW----NGITQQ 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 235 KSwnwmlPGLVYEyEKAEVDGLKTGSTDFAGYCFTGTAEKDGARYITVVMdakdhGQESYEARFSETAKLLDYAFDNFEV 314
Cdd:PRK11397 216 NR-----NGLLWD-KTMNVDGLKTGHTSGAGFNLIASAVDGQRRLIAVVM-----GADSAKGREEQARKLLRWGQQNFTT 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 315 KTLHPAGYTLKEKvKVAKGNEKEAKVTTKEPLKVVVEKGKNAKkaVETELVVNEKKLNndgkliAPIEKGEEVGYINVKY 394
Cdd:PRK11397 285 VQILHRGKKVGTE-RIWYGDKENIALGTEQDFWMVLPKAEIPH--IKAKYVLDGKELE------APISAHQRVGEIELYD 355

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 518224989 395 KDDQFGYLttdgdnqsgvPIVMKEDIDKANwfslMFRSIGDFF 437
Cdd:PRK11397 356 RDKQVAHW----------PLVTLESVGEGG----MFSRLSDYF 384
pbpG PRK11669
D-alanyl-D-alanine endopeptidase; Provisional
 12-286 7.55e-24

D-alanyl-D-alanine endopeptidase; Provisional


Pssm-ID: 236952  Cd Length: 306  Bit Score: 101.30  E-value: 7.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  12 VASLLVLQLWI-VAPIAHAQE------VDKPNLESGAAILVEAQTGKVLYEKDADAVRGIASMTKMMTEYLLLenihEGK 84
Cdd:PRK11669   7 LLSLLLLLAGVpFAPQAVAKTaaattaSQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVL----DAK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  85 LSWDDTyepsdYAYKISQNLSL----SNVPLakGEKYTLRELFEAMSMYSANGASIAIAEKIAGNETNFVKMMNEKAQEL 160
Cdd:PRK11669  83 LPLDEK-----LKVDISQTPEMkgvySRVRL--NSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAKAL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 161 GMKDAKFVNATGLsnsdlqgmqpkgtkaSDENLVSARSTAKL--ASHlinDYPEVLETSKLKEKT--FHKGkngetqmks 236
Cdd:PRK11669 156 GMTNTRYVEPTGL---------------SIHNVSTARDLTKLliASK---QYPLIGQLSTTREKTatFRKP--------- 208

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518224989 237 wNWMLP-----GLVYEyEKAEVDGLKTGSTDFAGYCFTGTAEKDGARYITVVMDA 286
Cdd:PRK11669 209 -NYTLPfrntnHLVYR-DNWNIQLTKTGFTNAAGHCLVMRTVINNRPVALVVLDA 261
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 312-422 1.51e-13

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 66.09  E-value: 1.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   312 FEVKTLHPAGYTLKeKVKVAKGNEKEAKVTTKEPLKVVVEKGKNAKkaVETELVVNEKKLNndgkliAPIEKGEEVGYIn 391
Cdd:smart00936   1 FETVKLYKKGQVVG-TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKK--LKAKVVLDKPELE------APIKKGQVVGTL- 70

                           90       100       110
                   ....*....|....*....|....*....|.
gi 518224989   392 vkykddqfgYLTTDGDNQSGVPIVMKEDIDK 422
Cdd:smart00936  71 ---------VVTLDGKLIGEVPLVALEDVEK 92
PBP5_C pfam07943
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 312-422 4.68e-12

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 429749 [Multi-domain]  Cd Length: 91  Bit Score: 61.84  E-value: 4.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  312 FEVKTLHPAGYTLKeKVKVAKGNEKEAKVTTKEPLKVVVEKGKNAKKAVETELvvnekklnnDGKLIAPIEKGEEVGYIN 391
Cdd:pfam07943   1 FETKKLYKKGDVVK-KVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTL---------KKPLEAPIKKGQVVGKLE 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 518224989  392 VKYKDDQFGYlttdgdnqsgVPIVMKEDIDK 422
Cdd:pfam07943  71 VYLDGKLIGE----------VPLVAKEDVEE 91
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
 65-209 3.85e-06

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 47.65  E-value: 3.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   65 ASMTKMMTEYLLLENIHEGKLSWDD--TYEPSDYAYKiSQNLSlsnvPLAKGEKYTLRELFEAMSMYSANGASIAIAEKI 142
Cdd:pfam13354  24 ASTIKVPILLAVLEQVDEGKLSLDErlTVTAEDKVGG-SGILQ----YLPDGSQLSLRDLLTLMIAVSDNTATNLLIDRL 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518224989  143 AGNEtnfvkmMNEKAQELGMKDAKFVNATglsnsdlqgMQPKGTKASDENLVSARSTAKLASHLIND 209
Cdd:pfam13354  99 GLEA------VNARLRALGLRDTRLRRKL---------PDLRAADKGGTNTTTARDMAKLLEALYRG 150
AmpC COG1680
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
40-167 5.16e-06

CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];


Pssm-ID: 441286 [Multi-domain]  Cd Length: 355  Bit Score: 48.53  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  40 GAAILVeAQTGKVLYEK-------------DADAVRGIASMTKMMTEYLLLENIHEGKLSWDDT-------YEPSDYAYK 99
Cdd:COG1680   34 GAAVAV-VRDGKVVYEKaygvadletgrpvTPDTLFRIASVTKSFTATAVLQLVEEGKLDLDDPvskylpeFKLPDDAKR 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 100 -------------ISQNLSLSNVPLAKGEKYTLRELFEAMS------------MYSANGASIA--IAEKIAGneTNFVKM 152
Cdd:COG1680  113 ditvrhllthtsgLPDYEPDPYDAADVARPYTPDDLLARLAalpllfepgtrfSYSNLGYDLLgeIIERVTG--QPLEDY 190

                        170
                 ....*....|....*.
gi 518224989 153 MNEK-AQELGMKDAKF 167
Cdd:COG1680  191 LRERiFEPLGMTDTGF 206
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
49-209 2.06e-04

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 42.96  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  49 TGKVLyEKDADAVRGIASMTKMMTEYLLLENIHEGKLSWDD--TYEPSDYAYKiSQNLSLsnvpLAKGEKYTLRELFEAM 126
Cdd:COG2367   44 TGETV-GINADERFPAASTFKLPVLAAVLRQVDAGKLSLDErvTLTPEDLVGG-SGILQK----LPDGTGLTLRELAELM 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989 127 SMYSANGASIAIAEKIAGNEtnfvkmMNEKAQELGMKDAKFVNATglsnsdlqgMQPKGTKASDENLVSARSTAKLASHL 206
Cdd:COG2367  118 ITVSDNTATNLLLRLLGPDA------VNAFLRSLGLTDTRLDRKE---------PDLNELPGDGRNTTTPRDMARLLAAL 182


                 ...
gi 518224989 207 IND 209
Cdd:COG2367  183 YRG 185
Beta-lactamase pfam00144
Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 ...
 40-167 1.52e-03

Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 395092 [Multi-domain]  Cd Length: 327  Bit Score: 40.56  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989   40 GAAILVeAQTGKVLYEK-------------DADAVRGIASMTKMMTEYLLLENIHEGKLSWDDT---YEPSDyAYKISQN 103
Cdd:pfam00144  16 GVAVAV-TRDGKVVVDRgggvadleggrpvTADTLFRIASVTKTFTAAAVLQLVERGKLDLDDPvskYLPEF-AGPGKGG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518224989  104 LSLSNV-------------PLAKGEKYTLRELFEAMS------------MYSANGASIA--IAEKIAGneTNFVKMMNEK 156
Cdd:pfam00144  94 ITLRDLlthtsglpplfapDDLEEAAADAAELVRALAalppvwppgtrwGYSNTAYGLLgeLLERVTG--QSYEELLGDR 171

                         170
                  ....*....|..
gi 518224989  157 -AQELGMKDAKF 167
Cdd:pfam00144 172 iLRPLGMTDTEL 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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