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Conserved domains on  [gi|518297934|ref|WP_019468142|]
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MULTISPECIES: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Staphylococcus]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10013199)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

EC:  6.3.2.6
Gene Ontology:  GO:0005524|GO:0004639

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-233 7.94e-132

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


:

Pssm-ID: 181800  Cd Length: 238  Bit Score: 370.98  E-value: 7.94e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   1 MSLLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKS 80
Cdd:PRK09362   4 KELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLVKK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  81 VEIIPLEVVVRNIAAGSITKRLGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLI 160
Cdd:PRK09362  84 VEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDVLK 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518297934 161 ELMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYSDTNFDKDVYREDTGSIIETYQTFLNKLEEL 233
Cdd:PRK09362 164 GLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGEL 236
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-233 7.94e-132

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 370.98  E-value: 7.94e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   1 MSLLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKS 80
Cdd:PRK09362   4 KELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLVKK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  81 VEIIPLEVVVRNIAAGSITKRLGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLI 160
Cdd:PRK09362  84 VEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDVLK 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518297934 161 ELMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYSDTNFDKDVYREDTGSIIETYQTFLNKLEEL 233
Cdd:PRK09362 164 GLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGEL 236
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 3-232 8.14e-127

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 357.92  E-value: 8.14e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   3 LLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSVE 82
Cdd:cd01415    1 LLYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  83 IIPLEVVVRNIAAGSITKRLGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLIEL 162
Cdd:cd01415   81 IIPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEF 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934 163 MDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYSDTNFDKDVYREDTGSIIETYQTFLNKLEE 232
Cdd:cd01415  161 FAEIGIILVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 3-224 3.81e-107

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 308.14  E-value: 3.81e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934    3 LLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSVE 82
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   83 IIPLEVVVRNIAAGSITKRL-GFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLIE 161
Cdd:pfam01259  81 IIPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518297934  162 LMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDK--YSDTN--FDKDVYREDTGSIIETYQ 224
Cdd:pfam01259 161 YAAERGIILVDTKLEFGLDSDGEIVLADEITPDSSRFWDAdtYEKSQesLDKDRFRDDLGDVEEAYQ 227
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-230 3.98e-103

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 298.53  E-value: 3.98e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   1 MSLLYEGKAKRIFSTAQsDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKS 80
Cdd:COG0152    4 LELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREMLVKK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  81 VEIIPLEVVVRNIAAGSITKR--------LGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAA 152
Cdd:COG0152   83 LEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELRELA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518297934 153 KTINTVLIELMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYSDTNFDKDVYREDTGS-IIETYQTFLNKL 230
Cdd:COG0152  163 LKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGnTSEAYIEVLERL 241
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 3-225 5.32e-85

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 252.32  E-value: 5.32e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934    3 LLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSVE 82
Cdd:TIGR00081   8 KLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREMLVKKLD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   83 IIPLEVVVRNIAAGSITKRLGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLIEL 162
Cdd:TIGR00081  88 IIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNEVLKKY 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518297934  163 MDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYS----DTNFDKDVYREDTGSIIETYQT 225
Cdd:TIGR00081 168 FDEKGIILVDFKLEFGLDEEGNLILADEVSPDTCRLWDKETyevgAPKLDKDIFRRTLGKLIEAYET 234
 
Name Accession Description Interval E-value
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 1-233 7.94e-132

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 370.98  E-value: 7.94e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   1 MSLLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKS 80
Cdd:PRK09362   4 KELLYEGKAKIVYSTDDPDLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKLEEAGIPTHFIEKLSDREQLVKK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  81 VEIIPLEVVVRNIAAGSITKRLGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLI 160
Cdd:PRK09362  84 VEIIPLEVVVRNVAAGSLVKRLGIEEGTVLPPPIVEFYYKNDALGDPMINEDHILALGWATPEELAEIKELALKINDVLK 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518297934 161 ELMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYSDTNFDKDVYREDTGSIIETYQTFLNKLEEL 233
Cdd:PRK09362 164 GLFAGAGIRLVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETNEKLDKDRFRRDLGGVIEAYEEVLKRLGEL 236
SAICAR_synt_PurC cd01415
bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) ...
 3-232 8.14e-127

bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; A subfamily of SAICAR synthetases represented by the Thermotoga maritima (Tm) enzyme and E. coli PurC. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133470  Cd Length: 230  Bit Score: 357.92  E-value: 8.14e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   3 LLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSVE 82
Cdd:cd01415    1 LLYEGKAKIVYATDDPDVLIVEFKDDATAFNGKKKDTIEGKGVLNNEISALIFKYLEENGIKTHFIEKLSDREQLVKKVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  83 IIPLEVVVRNIAAGSITKRLGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLIEL 162
Cdd:cd01415   81 IIPLEVVVRNIAAGSLVKRLGIEEGTVLDPPIVEFYYKNDELGDPLINEDHILALGLATEEELKEIKELALKINEVLSEF 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934 163 MDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYSDTNFDKDVYREDTGSIIETYQTFLNKLEE 232
Cdd:cd01415  161 FAEIGIILVDFKLEFGRDKDGEIVLADEISPDTCRLWDKETGEKLDKDRFRRDLGDVIEAYEEVLKRLGE 230
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 3-224 3.81e-107

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 308.14  E-value: 3.81e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934    3 LLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSVE 82
Cdd:pfam01259   1 LLYEGKVKDVYETDDPDTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEIAGIPTHFIKSLSGREMLVKKVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   83 IIPLEVVVRNIAAGSITKRL-GFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLIE 161
Cdd:pfam01259  81 IIPLEVVVRNYAAGSLGKRLpGLKEGTKLPEPIFEPSTKADALGDPNINEEHIVALGLATEEEAEEIRELALKINEILKE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518297934  162 LMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDK--YSDTN--FDKDVYREDTGSIIETYQ 224
Cdd:pfam01259 161 YAAERGIILVDTKLEFGLDSDGEIVLADEITPDSSRFWDAdtYEKSQesLDKDRFRDDLGDVEEAYQ 227
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 1-230 3.98e-103

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 298.53  E-value: 3.98e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   1 MSLLYEGKAKRIFSTAQsDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKS 80
Cdd:COG0152    4 LELLYEGKVKDVYATDD-DTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIGIPTHFIETLSGREMLVKK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  81 VEIIPLEVVVRNIAAGSITKR--------LGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAA 152
Cdd:COG0152   83 LEMIPVEVVVRNYAAGSLWKRyqagialpLGLEEGTKLPEPIFEPSTKADEGHDPNISEEHIVALGLATEEEAEELRELA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518297934 153 KTINTVLIELMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYSDTNFDKDVYREDTGS-IIETYQTFLNKL 230
Cdd:COG0152  163 LKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEITPDSSRLWDADTYESLDKDRFRDWLGGnTSEAYIEVLERL 241
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 3-225 5.32e-85

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 252.32  E-value: 5.32e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934    3 LLYEGKAKRIFSTAQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSVE 82
Cdd:TIGR00081   8 KLYSGKAKDIYETDDPDLLRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEAGIPTHYIDLIEDREMLVKKLD 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   83 IIPLEVVVRNIAAGSITKRLGFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLIEL 162
Cdd:TIGR00081  88 IIPLEVIVRNIAAGSLLKRLGIPEGLELEQPLVEFIFKPDEVGDPMLNESYAEALGLATEEELERIKELALKVNEVLKKY 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518297934  163 MDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDKYS----DTNFDKDVYREDTGSIIETYQT 225
Cdd:TIGR00081 168 FDEKGIILVDFKLEFGLDEEGNLILADEVSPDTCRLWDKETyevgAPKLDKDIFRRTLGKLIEAYET 234
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 3-231 5.50e-66

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 203.85  E-value: 5.50e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   3 LLYEGKAKRIFSTaQSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSVE 82
Cdd:cd00476    1 TLYRGKTKIVYET-KDGVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKYLSEAGIPTHFVERLGPRTLLVDKLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  83 IIPLEVVVRNIAAGSITKRL-GFDKGHTFESPLVEFFYKNDDLNDPLITEDHIQLLHLASKEEIEKLKEAAKTINTVLIE 161
Cdd:cd00476   80 *IPLEVVVRNRATGSFVKRYgGFKEGREFPPPLVEFFYKDDAEHDPIVSEDQLERLGFIGKVDVER*KELAVKINTVLKK 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518297934 162 LMDGMDLRLVDFKIEFGRSEDGQILLADEISPDTCRIWDK--YSDTNfDKDVYREDTGSIIETYQTFLNKLE 231
Cdd:cd00476  160 LFSPAGLELWDFKLEFGLDEEGEIVLGDEISPDSSRLWRKggEPYDK-DLFRRRASLGQIIEKYEEVAELVR 230
SAICAR_synt_Ade5 cd01416
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 3-214 7.66e-54

Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133471  Cd Length: 252  Bit Score: 173.25  E-value: 7.66e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   3 LLYEGKAKRIFSTA-QSDVLRIEYKDEVTAGNGAKKDFVEGKGRLNNQITSRIFSFIQERDIDSHFIEQLSETEQLVKSV 81
Cdd:cd01416    6 KLIEGKTKIVYELPdQPGLVLIQSKDRITAGDGARKDEIEGKAAISNKTTSNVFELLQEAGIKTHFVKQCSPTAFIARKC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  82 EIIPLEVVVRNIAAGSITKR-LGFDKGHTFESPLVEFFYKNDDLNDPLITEDhiQLLH--------LASKEEIEKLKEAA 152
Cdd:cd01416   86 EMIPIEWVCRRIATGSFLKRnPGVKEGYRFSPPKLEFFYKDDANHDPQWSEE--QLLEaklncgglKIGKKEVDIMTKST 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518297934 153 KTINTVLIELMDGMDLRLVDFKIEFGRSED-GQILLADEISPDTCRIW---DKySDTNfDKDVYRE 214
Cdd:cd01416  164 IAIFEILEKAWATQDCTLVDMKIEFGVDVTtGEILLADVIDNDSWRLWpsgDK-RLMK-DKQVYRN 227
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 3-213 8.39e-23

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 93.38  E-value: 8.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934   3 LLYEGKAKRIFSTAQSDVLrIEYKDEVTA-----GNGakkdfVEGKGRLNNQITSriFSFIQ-ERDIDSHFIEQLSETEQ 76
Cdd:cd01414    1 LIYSGKVRDVYDLGDGRLL-FVATDRISAfdvilPPD-----IPGKGEVLTQISA--FWFELtEDIIPNHLISTDVEDLP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  77 -------------LVKSVEIIPLEVVVRNIAAGSITKRL-------------GFDKGHTFESPLVEFFYKNDDLNDPLIT 130
Cdd:cd01414   73 eikepedpdgrsmVVKKAKPIPIECIVRGYLTGSGWKEYqkggtvcgiklpeGLREAQKLPEPIFTPSTKAEEGHDENIS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934 131 EDHIqlLHLASKEEIEKLKEAAKTINTVLIELMDGMDLRLVDFKIEFGRSEDGQILLADEI-SPDTCRIW--DKYSD--- 204
Cdd:cd01414  153 FEEA--VEIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVlTPDSSRFWpaDSYEPgke 230

                        250
                 ....*....|
gi 518297934 205 -TNFDKDVYR 213
Cdd:cd01414  231 qPSFDKQFVR 240
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 43-214 2.26e-12

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 64.91  E-value: 2.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  43 KGRLNNQITSriFSFIQERDI-DSHFIEQLSETEQLVKSVEIIPLEVVVRNIAAGSiTKRLgFDKGH--TFESPLVEFFY 119
Cdd:PRK12607  55 KGQVLNQTAA--FWFEATKDIcPNHVLAVPDPNVVVGKRCEPFPVEMVVRGYLAGS-TWRL-YKAGKreMYGVTLPDGLR 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934 120 KNDDLNDPLIT---------------EDHIQLLHLASKEEIEKLKEAAKTINTVLIELMDGMDLRLVDFKIEFGRSEDGQ 184
Cdd:PRK12607 131 ENQKLPEPIITpttkaeegghdepisPEEILAQGLLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGR 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 518297934 185 ILLADEI-SPDTCRIWdkYSDT------------NFDKDVYRE 214
Cdd:PRK12607 211 IVLIDEIhTPDSSRYW--YADGyeerfaagepqeQLDKEFVRQ 251
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 43-213 1.79e-10

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 59.84  E-value: 1.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  43 KGRLNNQiTSrIFSFIQERDI-DSHFIEQLSETEQLVKSVEIIPLEVVVRNIAAGSITKRL--GFDKG------HTFESP 113
Cdd:PLN02544 114 KGQVLNQ-TS-AWWFNNTKHItPNALVSSPDPNVTIAKKCSVFPVEFVVRGYMTGSTSTSLwtVYNKGvrnycgNDLPDG 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934 114 LVeffyKNDDLNDPLIT-----EDH--------IQLLHLASKEEIEKLKEAAKTINTVLIELMDGMDLRLVDFKIEFGRS 180
Cdd:PLN02544 192 MV----KNQKLPANILTpttkaADHdvpispeeIVEEGLMTQEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFGKD 267

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 518297934 181 EDGQILLADEI-SPDTCRIW--DKYSD--------TNFDKDVYR 213
Cdd:PLN02544 268 ADGTILLIDEVhTPDSSRYWlaDSYEErhaaglepENIDKEFLR 311
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 83-214 7.14e-09

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 55.07  E-value: 7.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  83 IIPLEVVVRN--IAAGSITKRL----------GFDKGH------TFESPLVEFFYKNDDlNDPLITEDHIQLLHLASKEE 144
Cdd:PRK13959 121 LIPLEVIFRNyvPVGSSLRDRIkegkikpedlGLDADEwpeegvKLPEPIVEFSTKYEE-QDRYLSRKEADEIAGLSRAE 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518297934 145 IEKLKEAAKTINTVLIELMDGMDLRLVDFKIEFGRSEDGQILLADEI-SPDTCRIwdKYSDTNFDKDVYRE 214
Cdd:PRK13959 200 IEELEELALKVDEIITEEAEKRGLIHEDGKIEFALYEEREIRVVDVVgTFDENRF--SYEGQELSKEVVRQ 268
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 42-209 6.79e-07

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 49.04  E-value: 6.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934  42 GKGRLNNQITsrIFSFIQERDI-DSHFIEQLSET-------EQ------LVKSVEIIPLEVVVRNIAAGSITK---RLGF 104
Cdd:PRK13961  52 DKGRVLTQMS--NFWFDKLAHIvPNHLTGIDVDDvvpadeaDQvlgravVVKKLKPLPVECVVRGYLTGSGWKdyqATGT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934 105 DKGHTFESPLVEffykNDDLNDPLITE-------DH---I---QLLHLASKEEIEKLKEAAKTINTVLIELMDGMDLRLV 171
Cdd:PRK13961 130 VCGIKLPAGLVE----ASKLPEPIFTPatkaelgDHdenIsfeEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIA 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 518297934 172 DFKIEFGRSEDGQILLADEI-SPDTCRIW--DKY----SDTNFDK 209
Cdd:PRK13961 206 DTKFEFGLDEDGTLTLMDEVlTPDSSRFWpaDSYqpgtSQPSFDK 250
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 122-221 1.06e-04

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 42.38  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518297934 122 DDLNdplIT----EDHIQLLHLASKEEI---EKL-KEAAKTINTVLIELmdgmDLRLVDFKIEFGRSEDGQ----ILLAD 189
Cdd:PRK13960 188 DDVN---ISrsdiEANYQAFNFSSADDIdlyEKLlKEGFKVISDALAKL----DQIFVDTKFEFGYVTDAAgnekLIYMD 260

                         90       100       110
                 ....*....|....*....|....*....|...
gi 518297934 190 EI-SPDTCRIWDKYSdtnfdkdvYREdtGSIIE 221
Cdd:PRK13960 261 EVgTPDSSRIWDGAA--------YRD--GKIVE 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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