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Conserved domains on  [gi|518315994|ref|WP_019486201|]
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helix-turn-helix transcriptional regulator [Pseudomonas aeruginosa]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10007659)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
2-67 2.78e-22

DNA-binding transcriptional regulator, XRE family [Transcription];


:

Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 80.96  E-value: 2.78e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518315994  2 PIEIRLDVMLALRKARSKDLAQAIGITEQNLSLFKQGKVKGIRLATLEAICAYLACQPGNLPEYLP 67
Cdd:COG3655   1 MIYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLLEYVP 66
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
2-67 2.78e-22

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 80.96  E-value: 2.78e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518315994  2 PIEIRLDVMLALRKARSKDLAQAIGITEQNLSLFKQGKVKGIRLATLEAICAYLACQPGNLPEYLP 67
Cdd:COG3655   1 MIYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLLEYVP 66
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 6-67 8.19e-19

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 71.80  E-value: 8.19e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518315994   6 RLDVMLALRKARSKDLAQAIGITEQNLSLFKQGKVKGIRLATLEAICAYLACQPGNLPEYLP 67
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPKRVSLDTLDKICDALGCQPGDLLEYVP 62
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-62 3.48e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 32.14  E-value: 3.48e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 518315994 12 ALRKARS---KDLAQAIGITEQNLSLFKQGKVKgIRLATLEAICAYLACQPGNL 62
Cdd:cd00093   6 ELRKEKGltqEELAEKLGVSRSTISRIENGKRN-PSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
12-59 7.73e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 31.33  E-value: 7.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 518315994   12 ALRKARS---KDLAQAIGITEQNLSLFKQGKVKgIRLATLEAICAYLACQP 59
Cdd:smart00530  4 ELREEKGltqEELAEKLGVSRSTLSRIENGKRK-PSLETLKKLAKALGVSL 53
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
2-67 2.78e-22

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 80.96  E-value: 2.78e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518315994  2 PIEIRLDVMLALRKARSKDLAQAIGITEQNLSLFKQGKVKGIRLATLEAICAYLACQPGNLPEYLP 67
Cdd:COG3655   1 MIYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLLEYVP 66
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 6-67 8.19e-19

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 71.80  E-value: 8.19e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518315994   6 RLDVMLALRKARSKDLAQAIGITEQNLSLFKQGKVKGIRLATLEAICAYLACQPGNLPEYLP 67
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPKRVSLDTLDKICDALGCQPGDLLEYVP 62
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
12-62 7.75e-04

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 34.20  E-value: 7.75e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 518315994 12 ALRKARS---KDLAQAIGITEQNLSLFKQGKVKgIRLATLEAICAYLACQPGNL 62
Cdd:COG1396  14 ELRKARGltqEELAERLGVSRSTISRIERGRRN-PSLETLLKLAKALGVSLDEL 66
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 12-62 3.48e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 32.14  E-value: 3.48e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 518315994 12 ALRKARS---KDLAQAIGITEQNLSLFKQGKVKgIRLATLEAICAYLACQPGNL 62
Cdd:cd00093   6 ELRKEKGltqEELAEKLGVSRSTISRIENGKRN-PSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
12-59 7.73e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 31.33  E-value: 7.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 518315994   12 ALRKARS---KDLAQAIGITEQNLSLFKQGKVKgIRLATLEAICAYLACQP 59
Cdd:smart00530  4 ELREEKGltqEELAEKLGVSRSTLSRIENGKRK-PSLETLKKLAKALGVSL 53
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
12-57 9.76e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 30.97  E-value: 9.76e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 518315994 12 ALRKARS---KDLAQAIGITEQNLSLFKQGKVKgIRLATLEAICAYLAC 57
Cdd:COG1476  11 ELRKERGltqEELAELLGVSRQTISAIENGKYN-PSLELALKIARALGV 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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