|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
50-432 |
1.02e-96 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 294.86 E-value: 1.02e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 50 FIAIASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIV 129
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 130 AGLGavwNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFA 209
Cdd:cd17474 81 CGLS---DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 210 FPVFCLLSLLAVVFLLKEPKKTKEPPKlgeYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLFYLSDILEKpPYSIDG 289
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEKAKSSS---ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLEL-LYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 290 VMKGFVLAIPLLGQVVTSYTTGANIKKnGTLMRWLMNIGLTLMtvALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLN 369
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKK-RFGARRILVIGLLLY--ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518364731 370 TMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDI-SHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIfGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-433 |
4.40e-48 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 168.52 E-value: 4.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 51 IAIASVPLVLVLGNSMIVPVLPDI-REKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIv 129
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIaQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 130 agLGAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFA 209
Cdd:cd17473 81 --AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 210 FpVFCLLSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEkgswLITAFFAGSLALFVLFGVLFYLSDILEKpPYSIDG 289
Cdd:cd17473 159 Y-LLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKR----VLPIYFLAFLAMLLFYVIPIQLPFLLQE-RGGGSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 290 VMKGFVLAIPLLGQVVTSYTTGanIKKNGTLMRWLMNIGLTLMTVALSLCIFLYdkNIYLFIGLLTLSSIGSGLLLPCLN 369
Cdd:cd17473 233 ALIGLALAIASLAGAIGALLFG--RLKRRLGKRRLLAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLN 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518364731 370 TMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFISVASMALLTLAFVFFLI 433
Cdd:cd17473 309 SWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
50-397 |
1.56e-44 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 158.60 E-value: 1.56e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 50 FIAIASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIV 129
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 130 AGLgavWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-WHAAFF 208
Cdd:COG2814 92 CAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 209 AFPVFCLLSLLAVVFLLKEPKKTKEPPKLGeymrQIGAILKEKGSWLitAFFAGSLALFVLFGVLFYLSDILEKpPYSID 288
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRG----SLRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLYLQE-VLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 289 GVMKGFVLAIPLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMtvALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCL 368
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGALLAGRLADRFG--RRRLLLIGLLLL--ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
|
330 340
....*....|....*....|....*....
gi 518364731 369 NTMIAGSVERDQRGMITSIYNSLRFLGVA 397
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
58-433 |
3.70e-44 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 158.12 E-value: 3.70e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwN 137
Cdd:cd17325 6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA---T 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 138 SYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPVFCLL 216
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 217 SLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAgSLALFVLFGVLF-----YLSDILEKPPYSIdgvm 291
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLA-IFVLAFAFGALEpflplYAAELGGLSPAQI---- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 292 kGFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTM 371
Cdd:cd17325 238 -GLLFGAQGLASALSQPPAGKLSDRIGR--KPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518364731 372 IAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAFVFFLI 433
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-430 |
9.92e-35 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 132.67 E-value: 9.92e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 51 IAIASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVA 130
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 131 GLGavwNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-WHAAFFA 209
Cdd:cd17324 82 ALA---PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLgWRAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 210 FPVFCLLSLLAVVFLLkePKKTKEPPKLGEYMRQIGAILKEKGSWLitAFFAGSLALFVLFGVLFYLSDILEKPPYSiDG 289
Cdd:cd17324 159 IAVLALLAALLLWRLL--PSLPPKKPGSLGLLSSLLLLLRNPRLRL--AYLITFLLFGGFFALYTYLAPFLTDVPGF-SS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 290 VMKGFVLAIPLLGQVVTSYTTGANIKKNGTlmrwLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLN 369
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADRGGR----RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQ 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518364731 370 TMIAgSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAFVF 430
Cdd:cd17324 310 TRVL-RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDhGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
58-400 |
1.75e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 131.39 E-value: 1.75e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLP-DIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAvw 136
Cdd:pfam07690 6 FLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 137 nSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-WHAAFFAFPVFCL 215
Cdd:pfam07690 84 -SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFgWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 216 LSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLFYLSDILEKppYSIDGVMKGFV 295
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV--LGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 296 LAIPLLGQVVTSYTTGANIKKNGTLMRWLMNIGLTLMtVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGS 375
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL-AALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 518364731 376 VERDQRGMITSIYNSLRFLGVAFGP 400
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
58-404 |
2.42e-32 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 126.13 E-value: 2.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwN 137
Cdd:cd17321 6 FLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA---P 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 138 SYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPVFCLL 216
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLeLFGWRWIFLINVPIGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 217 SLLAVVFLLkepkktkeppklgeymrqigailkekgSWLITAFFAGSLALFVLFGVLFYLSDILEKPPysidgVMKGFVL 296
Cdd:cd17321 163 ALLLARTFS---------------------------GAVLAAFLLGAALGGLLFLLPLYLQGVLGYSP-----LQAGLAL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 297 AIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVA-LSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGS 375
Cdd:cd17321 211 LPLALAMLVAAPLAGRLADRFGP--RLVLVAGLLLTAVGlLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSS 288
|
330 340
....*....|....*....|....*....
gi 518364731 376 VERDQRGMITSIYNSLRFLGVAFGPPLFS 404
Cdd:cd17321 289 VPKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
62-432 |
9.97e-32 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 124.61 E-value: 9.97e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAI 141
Cdd:cd17320 13 LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALA---SSIEQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 142 LIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-WHAAFFAFPVFCLLSLLA 220
Cdd:cd17320 90 LLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFgWRAIFVFLALLGLLLLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 221 VVFLLKE-PKKTKEPPKLGEYMRQIGAILKEKGSWLITafFAGSLALFVLFGVLFYLSDILEKpPYSIDGVMKGFVLAIP 299
Cdd:cd17320 170 VLLFLPEtLPEEKRKPLLSSLLRAYKRVLKNRRFLGYA--LALGLSFAGLFAYLAAAPFIYIE-QLGLSPAQFGLLFALN 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 300 LLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMTVA---LSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMiAGSV 376
Cdd:cd17320 247 AIALILGSLLNGRLVRRFG--PRRLLRLGLLLLLAAalvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL-ALEP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 518364731 377 ERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17320 324 FPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
65-435 |
1.11e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 124.21 E-value: 1.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 65 SMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIV 144
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA---TSFWQLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 145 GRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-WHAAFFAFPVFCLLSLLAVVF 223
Cdd:COG2271 104 LRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFW 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 224 LLkepkktkeppklgeymrqigailkekgswlitaFFAGSLALFVLFGVLFYLSDILEKPpYSIDGVMKGFVLAIPLLGQ 303
Cdd:COG2271 184 LL---------------------------------ALAYFLVYFALYGFLTWLPTYLVEV-RGLSLAQAGLLLSLPFLAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 304 VVTSYTTGANIKKNGTLMRWLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGM 383
Cdd:COG2271 230 IVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGT 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 518364731 384 ITSIYNSLRFLGVAFGPPLFSWMMDISH-RIVFISVASMALLTLAFVFFLIKP 435
Cdd:COG2271 308 ASGLVNTFGFLGGALGPLLVGYLLDATGyQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
58-432 |
2.66e-29 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 117.70 E-value: 2.66e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAvwn 137
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 138 SYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFCLLS 217
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 218 LLAVVFLLKEPKKTKEPPKLGEymRQIGAILKEKGSWLITAFFAgsLALFVLFGVLFYLSDILEkppySIDGVMKGFVLA 297
Cdd:cd17489 163 ALLLVFLVKDPPPVAAEEAEAG--TRAFRRLVEKKVLPPALILF--LASIAYGAISTFLPLYAA----ERGISNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 298 IPLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMtvALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVE 377
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKG--PKTVIIPGLLLL--ALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 518364731 378 RDQRGMITSIYNSLRFLGVAFGPPLFSWMMDI-SHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17489 311 PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
54-433 |
1.08e-28 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 115.75 E-value: 1.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 54 ASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLG 133
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 134 avwNSYAILIVGRAIQGLGAAgTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPV 212
Cdd:cd17504 82 ---PNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVqHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 213 FCLLSLLAVVFLlkepkktkePPKLgeymrqigaiLKEKGSWL--ITAFFAGsLALFVLFGVLFYLSDILEKPPYSIDGV 290
Cdd:cd17504 158 VAVLLAALVPLI---------DLRL----------LRRRNVLLanITALLAG-FGMFMVFQLLPQLLQLPTPTGFGLGIT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 291 MKGFVLAIPLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMTVALSLCIFLYDkNIYLFIGLLTLSSIGSGLLLPCLNT 370
Cdd:cd17504 218 EAGLLLLPGALVMLIAGPLAGRLIARVG--PRRVLLIGLVISAVGLLLLALLHS-SLWALVVALLLIGIGLGLAFASLPN 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518364731 371 MIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISH-RIVFISVASMALLTLAFVFFLI 433
Cdd:cd17504 295 IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTvSITSGGVPTEGAYVLAFLIGAA 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
53-432 |
3.61e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 114.45 E-value: 3.61e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 53 IASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIvagL 132
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL---L 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 133 GAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV---WHAAFFA 209
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfgWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 210 FPVFCLLSLLAVVFLLKEPK----KTKEPPKLGEYMRQIGAILKEKGSWLItaFFAGSLALFVLFGVLFYLSDILEKPPY 285
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPesarAKNEEASSKSVLKLLKRVLKNPGLWLL--LLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 286 SIDGVMkGFVLAIPLLGQVVTSYTTGANIKKNGTLmRWLMNIGLTLMTVALSLCIFLYdkNIYLFIGLLTLSSIGSGLLL 365
Cdd:cd06174 236 LSVAVA-GLLLSLFGLAGALGSLLLGLLSDRLIGR-KPLLLIGLLLMALGLALLLLAP--SLLLLLLLLLLLGFGLGGLL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518364731 366 PCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
65-436 |
2.00e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 112.67 E-value: 2.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 65 SMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIV 144
Cdd:COG2223 22 YLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA---VSYWLLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 145 GRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-WHAAFFAFPVFCLLSLLAVVF 223
Cdd:COG2223 99 LGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 224 LLKEPKKTKEPPKLGEyMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLF--YLSDIlekppYSIDGVMKGFVLAIPLL 301
Cdd:COG2223 179 FLRDPPAGAAAAAKAS-LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLppYLVDQ-----FGLSAATAGLLAALFAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 302 GQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALsLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQR 381
Cdd:COG2223 253 LGALGRPLGGWLSDRIGG--RRVLLIVFALMALGL-LLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNA 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 518364731 382 GMITSIYNSLRFLGVAFGPPLFSWMMDI--SHRIVFISVASMALLTLAFVFFLIKPK 436
Cdd:COG2223 330 GAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
71-404 |
2.46e-26 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 109.59 E-value: 2.46e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 71 LPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIVGRAIQG 150
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA---PNLASLIIFRILQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 151 LGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGS-LLALIVWHAAFFAFPVFCLLSLLAVVFLlkepk 229
Cdd:cd17503 96 FGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGwLTDNLSWRWIFYINLPIGILALLLAPLL----- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 230 ktkeppKLGeymrqigaILKEKGswLITAFFAGSLALFVLFGVLF----YLSDILEKPPYSIdgvmkGFVLAIPLLGQVV 305
Cdd:cd17503 171 ------DLR--------LFKDRN--FTLGLLLSFLLGLGLFGAMFllplYLQNVLGYSAFES-----GLVLAPGGLASAI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 306 TSYTTGANIKKNGtlMRWLMNIGLTLMTVALSLCIFL-YDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMI 384
Cdd:cd17503 230 LSPLVGRLLDKFG--PRLLLLAGLLLLALGTLLLAFLtPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDA 307
|
330 340
....*....|....*....|
gi 518364731 385 TSIYNSLRFLGVAFGPPLFS 404
Cdd:cd17503 308 TALFNTIRQLGGSIGTALLA 327
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
62-432 |
2.73e-24 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 103.03 E-value: 2.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLPDIREKLGvSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLgaVWNSYAi 141
Cdd:cd17502 10 LDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL--APNMTM- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 142 LIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFA-FPVFCLLSLL 219
Cdd:cd17502 86 LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTdHLSWRWCFYInLPIGGLALAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 220 AVVFLLkepkktkeppklgeymrqigailkekgSWLITAFFAGSLALFVLFGVLFYLSDILEKPpysidgVMKGFVLAIP 299
Cdd:cd17502 166 LRTILL---------------------------SSIFGFLFGGALFGLIYYLPLYFQLVLGDSA------TKSGVRLLPL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 300 LLGQVVTSYTTGANIKKNGTLmRWLMNIGLTLMTV-ALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVER 378
Cdd:cd17502 213 IIGLVIGSIISGALISKTGRY-KPLIVIGTILMSVgAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPP 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 518364731 379 DQRGMITSIYNSLRFLGVAFGpplfswmmdISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17502 292 ADVGVATATNTFFRSLGGTLG---------VAITDVFLVALALAALAFLLSLFL 336
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
35-436 |
6.63e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 99.95 E-value: 6.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 35 SKNEAGTGAKGHLWEFIAIASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKA 114
Cdd:COG2807 5 SSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 115 IIIPSLIIYGAAgivAGLGAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTeSKALGLTEAANGTGKVLSPIL 194
Cdd:COG2807 85 TLLLALLLLAAG---LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 195 GSLLALIV-WHAAFFAFPVFCLLSLLAVVFLLKEPKKTKEPPKLGeymRQIGAILKEKGSWLITAFFAGSLALFvlFGVL 273
Cdd:COG2807 161 TVPLAAALgWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA---ASLRSLWRSPLAWLLTLFFGLQSLLY--YAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 274 FYLSDILEkpPYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGTLmRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGL 353
Cdd:COG2807 236 AWLPPILR--DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 354 LtlsSIGSGLLLPCLNTMIAGSVER-DQRGMITSIYNSLRFLGVAFGPPLFSWMMDISH--RIVFISVASMALLTLAFVF 430
Cdd:COG2807 313 L---GLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGswTAALLLLAALAVLMLVAGL 389
|
....*.
gi 518364731 431 FLIKPK 436
Cdd:COG2807 390 LAGRPY 395
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
53-432 |
7.05e-23 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 99.21 E-value: 7.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 53 IASVPLVLVLGNSMIVPVL-PDIREKLGVSQFQSSLVITLFSVT-AGLVIPVsGYLSDRFSRKAIIIPSLIIYGAAGIVA 130
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLsVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILFGLLLFIAGSLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 131 GLGavwNSYAILIVGRAIQGLGAAGTApiAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAF 210
Cdd:cd17472 80 AYA---TSIYGLILGRALQGSGAISSV--VMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 211 -PVFCLLSLLAVVFLLKEPKKTKEPPKLGEymRQIGAILKEKGSWLITafFAGSLALFVLFGVLFYLSDILEKPPYSIDG 289
Cdd:cd17472 155 tAILSLVSLLILLFFVPDPPKIVQISEKEK--KKLKKLLKNKRLLRLD--FSIFILHFVLMAFFYILPLLLTQLGGGKGQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 290 VMKGFVLAIPLLGQVVTSYTTGANIKKNgtlMRWLMNIGLTLMTVALsLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLN 369
Cdd:cd17472 231 LWKVYLPAILIGFILMVPFVIYAEKKGK---MKQVFVSSILLIAVGF-LLLLFAATSLWLLIIGLIIFFIGFNLLEALLP 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518364731 370 TMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17472 307 SLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGlLGYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
67-433 |
1.31e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 99.23 E-value: 1.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 67 IVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIVGR 146
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFA---PNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 147 AIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV--WHAAFFAFPVFCLLSLLAVVFL 224
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATggWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 225 LKEPKKTKEPPKLGEYMRQIG------AILKEKGSWLIT------AFFAGSLALFVLFgVLFYLSDILEKPPYSIDGVMK 292
Cdd:cd17328 175 VREPPRGAAEGGVMAKSTATSfladlkALAKNPSFILSTlgftavSFVTGALAFWAPT-FFLRAFGVGDLSSADVGLIFG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 293 GFVLAIPLLGQVVTSYTTGANIKKNGTLMRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMI 372
Cdd:cd17328 254 AITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAIL 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518364731 373 AGSVERDQRGMITSIYNSL-RFLGVAFGPPLFSWMMDISHRIVFISVASM-----ALLTLAFVFFLI 433
Cdd:cd17328 334 LYVVIPTRRSTASAIQILLsHLLGDAGSPYLIGLISDLLRQNKDSPLAEAaslqyALLLCSFVLVLG 400
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
44-436 |
8.20e-22 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 96.46 E-value: 8.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 44 KGHLWEFIAIASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIY 123
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 124 GAAGIVAGLgavWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKgGTESKALGLTEAANGTGKVLSPILGSLLAL--- 200
Cdd:COG0738 84 ALGLLLFAL---APSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILlgl 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 201 -IVWHAAFFAFPVFCLLsLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLF--YLS 277
Cdd:COG0738 160 sLSWHLPYLILAVLLLL-LALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLplYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 278 DILekppySIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLS 357
Cdd:COG0738 239 DVL-----GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP--VRLLRLSALLAAVGLLLALLA--PGPWLALIGLALV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 358 SIGSGLLLPCLNTmIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISH-RIVFISVASMALLTLAFVFFLIKPK 436
Cdd:COG0738 310 GLGLSLMFPTIFS-LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
36-276 |
1.02e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 89.10 E-value: 1.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 36 KNEAGTGAKGHLWEFIAIASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAI 115
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 116 IIPSLIIYGAAGIVAGLgavWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILG 195
Cdd:COG0477 82 LLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 196 SLL-ALIVWHAAFFAFPVFCLLSLLaVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLF 274
Cdd:COG0477 159 GLLvAALGWRWIFLINAPLGLLALV-LRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237
|
..
gi 518364731 275 YL 276
Cdd:COG0477 238 AL 239
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
78-433 |
1.26e-19 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 90.73 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 78 LGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRK---------AIIIPSLIIYGAAGIVAGLGAVWNsYAILIVGRAI 148
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwilIGAIPLALSFVLLFTAPDLSPTGK-LIYALVTYLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 149 QGLGAAGTAPIAMALAGDLYKGGTE-SKALGLTEAANGTGKVLSPILGSLLALIV-------WHAAFFAFPVFCLLSLLA 220
Cdd:COG2211 120 LGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalgYRLTALIFAVLGLLAFLL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 221 VVFLLKEPKKTKEPPKlgEYMRQIGAILKEKG-SWLITAFFAGSLALFVLFGV-LFYLSDILEKPPYSIdgvmkGFVLAI 298
Cdd:COG2211 200 TFFGTKERPVPEEEKV--SLKESLKALLKNRPfLLLLLAYLLFFLALALVAALlLYYFKYVLGLSAALV-----GLLLAL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 299 PLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVER 378
Cdd:COG2211 273 YFLAALLGAPLWPRLAKRFGK--KKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDY 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518364731 379 DQ-------RGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFISVASMALLTLAFVFFLI 433
Cdd:COG2211 351 DEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
81-432 |
2.35e-19 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 89.21 E-value: 2.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 81 SQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWN--SYAILIVGRAIQGLGAAGTAP 158
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 159 IAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFC-LLSLLAVVFLLKEPKKTKEPPKL 237
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSfLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 238 GEYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLFYLSDILEKPPYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKN 317
Cdd:cd06173 192 LLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 318 GtlMRWLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVA 397
Cdd:cd06173 272 R--RGRLLLIGALLLGLALLVLGLS--PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMP 347
|
330 340 350
....*....|....*....|....*....|....*.
gi 518364731 398 FGPPLFSWMMD-ISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd06173 348 LGALLAGLLADaLGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-431 |
1.02e-18 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 86.86 E-value: 1.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLPDI---REKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNS 138
Cdd:cd17330 10 LGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS---RN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 139 YAILIVGRAIQGLGAaGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAA-FFAFPVFCLLS 217
Cdd:cd17330 87 LWLLFLARFLDGLTG-GNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALpFLVAAALALLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 218 LLAVVFLLKepkktkeppklgeYMRQIGAIlkekgSWLITAFFAGSLALFVLFGVLFYlsdilekppySIDGVMKGFVLA 297
Cdd:cd17330 166 LVLVLFFLP-------------PLRRLLLV-----YFLIALAFAGLESVFSLFLKDRF----------GFSPSQIGLLLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 298 IPLLGQVVTSYTTGANIKKNGTLMRwLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVE 377
Cdd:cd17330 218 LVGIAGILAQLLLIPRLAKRLGERK-LLRLGLLLAIIGLLLLPFA--SSVPLLVLAAAILAFGTGIVFPALSALLSKSVP 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 518364731 378 RDQRGMITSIYNSLRFLGVAFGPPLFSWMMDI-SHRIVFISVASMALLTLAFVFF 431
Cdd:cd17330 295 SKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFlGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
61-405 |
9.65e-18 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 84.61 E-value: 9.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 61 VLGNSMIVPVLPDIREKLGVSQFQSS----LVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIiygAAGIVAGLGAVW 136
Cdd:cd17388 12 AMGIGLIMPVLPTLLREFVGDSADAAthygVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLA---GAALDYLLMAFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 137 NSYAILIVGRAIQGLGAAgTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFCLL 216
Cdd:cd17388 89 PTLWWLYLGRIIAGITGA-TGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 217 SLLAVVFLLKEP-KKTKEPPKLGEYMRQIGAIlkekgsWLITAFfagsLALFVLFGVLFYLSDILEKPP----------Y 285
Cdd:cd17388 168 NFLLGLFVLPESlPPERRRAFRWRRANPFGSL------RWLTGF----PGLLGLLAVFFLIQLIGQVPAttwvlftedrF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 286 SIDGVMKGFVLAI-PLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMTVALSLCIFLyDKNIYLFIGLLTLSSigSGLL 364
Cdd:cd17388 238 DWSPTMVGLSLAVfGLLHALFQAFVTGPIAKRLG--EKRAILLGLAADALGFLLLAFA-TQGWMVFPILILLAL--GGIA 312
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 518364731 365 LPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSW 405
Cdd:cd17388 313 GPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTG 353
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
58-432 |
1.46e-17 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 83.82 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLPD-IREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVW 136
Cdd:cd17329 9 FLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 137 NSYAILIVgraIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFCLL 216
Cdd:cd17329 89 WLFAIALV---LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 217 SLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLF--YLSDILEKPPYSIDGVMKGF 294
Cdd:cd17329 166 AALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLpvYVVEILGLGESLLGLLLALN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 295 VLAIPLLGQVVTSYTTGANIKKngtlmrwLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAG 374
Cdd:cd17329 246 ALLIVLLQFPVARLVERFRLRK-------ILMIGILLFAIGFAVLAFA--NTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 375 SVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDlLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
64-430 |
3.20e-17 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 82.60 E-value: 3.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 64 NSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIygaAGIVAGLGAVWNSYAILI 143
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLL---TGLGLSLLGFAPNYWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 144 VGRAIQGLGAAGTAPIAMALAGDLYkGGTESKALGLTEAANGTGKVLSPILGSLLALivwHAAFFAFPVFCLLSLLAVVF 223
Cdd:cd17478 89 LLVALAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVA---LFGGLGLLILLIIPGLAVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 224 LLKePKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAGSLAL--FVLFGVLFYLSDILEKPPYSIdgVMKGFVLAIPLL 301
Cdd:cd17478 165 LLL-RLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLrsWVLSSLTTFLPFYLVQRGYSL--VFAGLLLSLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 302 GQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLYDKNIYLF---IGLLTLSSIGSGLLLpclntmiAGSVER 378
Cdd:cd17478 242 AGAIGTLIGGPLSDRFGR--RRVIIASLLLAAPFLLLFLLTPGIWSYILlvlAGFLLFASFPVTVVL-------AQELLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 518364731 379 DQRGMITSIYNSLRFLGVAFGPPLFSWMMDISH-RIVFISVASMALLTLAFVF 430
Cdd:cd17478 313 GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGlESVLLILALLPLLGALLAF 365
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
65-399 |
1.55e-16 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 80.77 E-value: 1.55e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 65 SMIVPvLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAvwnSYAILIV 144
Cdd:cd17476 16 SVIVI-LPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSP---NFIFFII 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 145 GRAIQGLGAAGTAPIAMALAGDLYKGGTE-SKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPVFCLLSLLAVV 222
Cdd:cd17476 92 CRALQGLGPAFLLPNAMALLGRTYPPGPRkNIVFSLFGATAPLGFALGGVFGGLFAqLAWWPWIFWFLAILAAIVAVAAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 223 FLLKepkktkeppklgeymRQIGAILkekgswLITAFFAGSLALFVLFGVLFYLSDILEKPpysIDGVMKGFVLAIpllG 302
Cdd:cd17476 172 FWTS---------------PSFIAVL------LAVFLGWASFGIWVFYATQYFQNVRGYSP---LLTSARFIPMAI---G 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 303 QVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLYDKNIY--LFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQ 380
Cdd:cd17476 225 GVLAAITVGFLIARLPP--SYIMAISMVAFLVGPILFATMPVHQTYwaQAFPAMIVAPFGMDFSFPAATIIASNAVPREY 302
|
330
....*....|....*....
gi 518364731 381 RGMITSIYNSLRFLGVAFG 399
Cdd:cd17476 303 QGLAGSLVNTVVNYGISIG 321
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
71-432 |
1.69e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 80.31 E-value: 1.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 71 LPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYgaaGIVAGLGAVWNSYAILIVGRAIQG 150
Cdd:cd17319 26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLW---SLFTALTGFATSLTSLYVLRFLLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 151 LGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVL-SPILGSLLALIVWHAAFFafpVFCLLSLLAVVFLLKepk 229
Cdd:cd17319 103 VAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIgPPLSGWLLLLFGWRWAFI---IEGLLGLLLAVLWWF--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 230 ktkeppklgeYMRQIgailkekgsWLITAFFAGslALFVLFGVLFYLSDILeKPPYSIDGVMKGFVLAIPLLGQVVTSYT 309
Cdd:cd17319 177 ----------YLRQV---------WGLALGYFG--INYALYGLLTWLPTYL-KQARGFSLKQVGLLAAIPFLAGAIGMIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 310 TGANIKKNGTLMR-WLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIY 388
Cdd:cd17319 235 GGRLSDRLLRGARrLVIIIGLLLAAVGLLLAYLT--TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLI 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 518364731 389 NSLRFLGVAFGPPLFSWMMDI--SHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17319 313 NSGGNLGGFVAPLLIGYLVDAtgSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-431 |
3.45e-16 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 79.62 E-value: 3.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLPDIREKLGVS-----QFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSliIYGAAGIVAGLGAVW 136
Cdd:cd17391 10 IGFSLIAPFLPLYIEQLGVTsgglvELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRA--SLGMAIVIGLMAFVT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 137 NSYAILIVgRAIQGLgAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPVFCL 215
Cdd:cd17391 88 NVWQLLIL-RLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLAdLFGIRNVFFITGGLLF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 216 LSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGswLITAFFAGSLALFVLFGVLFYLSDILEKPPYSIDGVM--KG 293
Cdd:cd17391 166 LAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSL--LISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAfiSG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 294 FVLAIPLLGQVVTSYTTGANIKKNGTlMRWLMnigLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIA 373
Cdd:cd17391 244 LVFSATGVSSLLSAPRLGKLGDRIGH-HRILL---GALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 374 GSVERDQRGMITSIYNSLRFLGVAFGPPLFSWM-MDISHRIVFISVASMALLTLAFVFF 431
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
68-433 |
1.86e-13 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 71.48 E-value: 1.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 68 VPVLPDIREKLGVSQFQSSLVITLFSVTAGLV-IPVsGYLSDRF-SRKAIIIPSLIIYGAAGIVAGLgavWNSYAILIVG 145
Cdd:cd17490 16 VPFLSPYAESLGASLSMIGIILGAYGISQMLLrIPL-GILSDRIgKRKLFIIIGLLFTVLASLIMIL---FPSPWGLLIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 146 RAIQGLGAAgTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFafpVFCLLSLLAVV-- 222
Cdd:cd17490 92 RFLSGIAAA-TWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFL---LAALAGVLGFIls 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 223 FLLKEPKKTKEPpkLGEYMRQIGAILKEKGSWLITafFAGSLALFVLFGVLFYLSDILEKPPYSIDGVMkGFVLAIPLLG 302
Cdd:cd17490 168 LFIKEERREKKP--VLTELKELLSVLKDKKLLFFS--LLAILQQMITFSTTFGFTPLIAKQLGASSFQL-GLLSIIYLLP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 303 QVVTSYTTGAN-IKKNGTlmRWLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQR 381
Cdd:cd17490 243 NALASLLSGTLfYKKLGE--RNTIIIGFLLLGAYCFLIPFA--PNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQR 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 518364731 382 GMITSIYNSLRFLGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAFVFFLI 433
Cdd:cd17490 319 STAMGFFQAIYALGMFLGPVLVGIISEaFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
74-230 |
1.71e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.36 E-value: 1.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 74 IREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIiPSLIIYGAAGIVAGLGAVWNSYAILIVGRAIQGLGA 153
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL-VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGL 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518364731 154 AGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPIL-GSLLALIVWHAAFFAFPVFCLLSLLAVVFLLKEPKK 230
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLvGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
62-432 |
1.94e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.45 E-value: 1.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLPDIREkLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAgivAGLGAVWNSYAI 141
Cdd:cd17355 18 IRYYFGVFIIPIIAE-FGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG---LVLLALATSLWQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 142 LIVGRAIQGLGAAGTAPIAMALAGDLYKGGTE-SKALGLTEAANGTGK-VLSPILGSLLALIVWHAAFFAFPVFCLLSLL 219
Cdd:cd17355 94 LYLLWGLLGGGGAGTLAAVAFATVAAWWFERRrGLALGILTAGGGLGSlVFLPLGAALIEAFGWRTALLVLALLALLVLV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 220 AVVFLL-----KEPKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAgsLALFVLFGVLFYLsdilekPPYSIDGVMKGF 294
Cdd:cd17355 174 PVLLLLrrrpaDLALRAYDDASPASPGSTLKEALRSASFWLLALAFF--LCGFAVVGLIVHL------VPYLADRGISPA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 295 VLAIPL----LGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMTVALSLCIFLyDKNIYLFIGLLTLSSIGSGLLLPCLNT 370
Cdd:cd17355 246 AAAVALaligLFNIVGRLLSGWLGDRYS--PRRLLAASYALRALGLALLLLL-PFPPLALLLFAALFGLGWGATVPLTAA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518364731 371 MIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17355 323 LAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
66-240 |
2.81e-12 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 68.01 E-value: 2.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 66 MIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIVG 145
Cdd:PRK11652 26 IYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFA---HSLTVLIAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 146 RAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPVFCLLSLLAVVFL 224
Cdd:PRK11652 103 SAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTtLFGWRACYLFLLLLGAGVTFSMARW 182
|
170
....*....|....*...
gi 518364731 225 LKE--PKKTKEPPKLGEY 240
Cdd:PRK11652 183 MPEtrPADARRTRVLASY 200
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
62-262 |
3.71e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 67.63 E-value: 3.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLPDIREKLGVSQfqSSLVITLFSVTAGLVIP--VSGYLSDRFSRKAIIIPSLIIYGAAGIVaglGAVWNSY 139
Cdd:PRK11102 5 LAIDMYLPALPVIAADFGVSA--GSVQMTLSAYILGFAIGqlFYGPMADSFGRKPVILGGTLVFALAAVA---CALAQTI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 140 AILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-WHAAFFAFPVFCLLSL 218
Cdd:PRK11102 80 DQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFsWHAIFWVLALAAILAA 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 518364731 219 LAVVFLLKE--PKKTKEPPKLGEYMRQIGAILKEK---GSWLITAF-FAG 262
Cdd:PRK11102 160 ALVFFFIPEtlPKERRQPFHLRTTIRNFASLFRHKrvlGYMLASGFsFAG 209
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
254-435 |
9.30e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 66.10 E-value: 9.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 254 WLITAFFAGSLALFVLFGVLF-YLSDilekpPYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLM 332
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAiYLHQ-----QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR--KPVMLAGLLLR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 333 TVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHR 412
Cdd:cd17329 76 ALGFALLGFA--HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR 153
|
170 180
....*....|....*....|...
gi 518364731 413 IVFISVASMALLTLAFVFFLIKP 435
Cdd:cd17329 154 LLFLAAAVLFLLAALVLLFLLPE 176
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
66-430 |
1.48e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 62.56 E-value: 1.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 66 MIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRF-SRKAIIIpslIIYGAAGIVAGLGAVWNSYAILIV 144
Cdd:cd17370 17 MARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTgKRKPLVI---LGYGLSALAKPLLALAGSWQLVLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 145 GRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHA-----AFFAFPVFCLLSLL 219
Cdd:cd17370 94 LRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrtifLLAAIPALLALLIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 220 AVVFLLKEPKKTKEPPKLGEYMRQIGAILkekgsWLITAFFAGSLALFVLFGVLFYLSDILEKPPYSIdgvmkGFVLAIP 299
Cdd:cd17370 174 LFVVKEYPRPPKLRKKSKKTSLKKLPKAF-----WLYLLAVALFALGNFSFAFLILRAQELGLSAALI-----PLLYALF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 300 LLGQVVTSYTTGANIKKNGtlMRWLMNIGltLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERD 379
Cdd:cd17370 244 NLVYALAAYPAGRLSDRIG--RKKLLILG--YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 518364731 380 QRGMITSIYNSLRFLGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAFVF 430
Cdd:cd17370 320 LRGTAYGLFNTVVGIGWLLASLIAGYLWDlISPSAAFLFSAVLALIALLLLL 371
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
55-248 |
2.22e-10 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 62.40 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 55 SVPLVLVLGNSMIVPV-LPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLG 133
Cdd:TIGR00711 8 MLGTFMAVLDSTIVNVaIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 134 avwNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGS-LLALIVWHAAFFAFPV 212
Cdd:TIGR00711 88 ---PNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGwIIENYHWRWIFLINVP 164
|
170 180 190
....*....|....*....|....*....|....*.
gi 518364731 213 FCLLSLLAVVFLLKEPKktkepPKLGEYMRQIGAIL 248
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDK-----PAASENFDFLGLLL 195
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
53-227 |
2.23e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.82 E-value: 2.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 53 IASVPLVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGL 132
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 133 GavwNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFP 211
Cdd:cd17323 84 A---PNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITqSLGWRWIFWFLA 160
|
170
....*....|....*.
gi 518364731 212 VFCLLSLLAVVFLLKE 227
Cdd:cd17323 161 IISGFCLILIFLFLPI 176
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
90-433 |
2.55e-10 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 61.91 E-value: 2.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 90 TLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIiygAAGIVAGLGAVWNSYAILIVGRAIQGLgAAGTAPIAMALAGDLYK 169
Cdd:cd17389 71 SLFSLLQFLSSPITGAASDVYGRKPVLLLTMI---GLAISYALWAVSRSFTIFLLSRIVGGI-SKGNVSLSTAIVADVTS 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 170 GGTESKALGLTEAANGTGKVLSPILGSLLAL------IVWH--AAFFAFpVFCLLSLLAVVFLLKEpkktkeppKLGEYM 241
Cdd:cd17389 147 PKKRSKGMALIGVAFSLGFIIGPMIGAYFASftrslgEVFFsmPALFAL-VLALADLLFIFFFLPE--------TLPSNL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 242 RQIGAIlkekgswlitaFFagsLALFVLFGVLFYLSDIL-EKPPYSI--DGVM---KGFVLAIpLLGQVVTSYTTGANIK 315
Cdd:cd17389 218 RRLGLV-----------YF---LYLFLFSGLEFTLTFLThQRFQYTSmqQGKMfffIGIIMAL-VQGGYVRRIKPGKEKK 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 316 kngTLMRwlmniGLTLMTVALsLCIFLYDKNIYLFIGlLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLG 395
Cdd:cd17389 283 ---AVLQ-----GLILLIPAF-LLIGWASSVTVLYAG-LFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALA 352
|
330 340 350
....*....|....*....|....*....|....*...
gi 518364731 396 VAFGPplfswmmdISHRIVFISVASMALLTLAFVFFLI 433
Cdd:cd17389 353 RALGP--------IVACTVYWLAGSEACYTIGALLFLL 382
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
48-432 |
4.21e-10 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 61.27 E-value: 4.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 48 WEFIAIASVPLVLVLGNSMIVPVL-PDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIiipslIIYGAA 126
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFyQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPL-----MALAGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 127 GIVAG---LGAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKgGTESKALGLTEAANGTGKVL-SPILGSLLALIV 202
Cdd:cd17314 77 MVLAGytyLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLgSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 203 WHAAF--FAFPVFCLLSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLItaffagSLALFVLFGVLFYLSDIL 280
Cdd:cd17314 156 LALVYtiLGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWIL------FIAIFLVLIGGFLFIANM 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 281 EKPPYSIDGVMKGFV---LAIPLLGQVVTSYTTG--ANIKKNGTLMRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLT 355
Cdd:cd17314 230 ASLVRSLQLDAPSFVtklMSIYGLFNAFGRLLWGivADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLG 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518364731 356 LSSIGSGLLLPCLNTMIAGSverDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17314 310 FSYGGLFTVYPATVSTVFGT---ESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
259-436 |
1.03e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 259 FFAGSLALFVLFGVLFYLSDILEKPpYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSL 338
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAED-LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR--RRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 339 CIFLYdkNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISH-RIVFIS 417
Cdd:pfam07690 79 LLFAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwRAAFLI 156
|
170
....*....|....*....
gi 518364731 418 VASMALLTLAFVFFLIKPK 436
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPP 175
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
62-435 |
1.60e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 59.16 E-value: 1.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIiygAAGIVAGLGAVWNSYAI 141
Cdd:cd17390 10 FGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLL---LTALGYVLLGFSTSLAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 142 LIVGRAIQGLgAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLAliVWHAAFFafpVFCLLSllAV 221
Cdd:cd17390 87 LFLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLA--ETDGGFY---YVALLC--SA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 222 VFLlkepkktkeppklgeymrqIGAILkekgSWLITAFFAGSLALFVLFG--VLFYLSD--ILEKPPYSIDGVMKGFVLA 297
Cdd:cd17390 159 IFI-------------------LNAGL----VWFLLSKLWDLLLVRFLMGfsVLLFRSNfsLYLEERFDLSPKTIGYLIS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 298 IPLLGQVVTSYTTG---ANIKKNGTLMrwlmnigLTLMTVALSLCIFLY--DKNIYLFIGLLTLSSIGSGLLLPCLNTMI 372
Cdd:cd17390 216 YSGVLGALSGFLVGrilKLYKNNEYLL-------LLHSFILLALSLLGLalAPSIWLLVLCLTPLSISSAVLRTCSTSLL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518364731 373 AGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFIsVASMALLTLAFVFFLIKP 435
Cdd:cd17390 289 LSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGL-LGAVLALAAILLMLARQR 350
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
102-433 |
1.72e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.15 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 102 VSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTE 181
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 182 AANGTGKVLSPILGSLLALIV-----WHAAFFAFPVFCLLSLLAVVFLLKepkktkeppklgeymrqigailkekgSWLI 256
Cdd:cd17316 132 SGWALGALLAALVASLLIPLLsgdwgWRILFLIGALPALLALLLRRRTLL--------------------------LILL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 257 TAFFAgslalFVLFGVLFYLSDILEKpPYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMTVAL 336
Cdd:cd17316 186 WFFIS-----FGYYGLTTFLPTYLQT-VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG--RKKTLVIGLILSGILA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 337 SLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISHrivFI 416
Cdd:cd17316 258 LPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG---GT 334
|
330
....*....|....*..
gi 518364731 417 SVASMALLTLAFVFFLI 433
Cdd:cd17316 335 GVPALILALLAIVALIV 351
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
255-434 |
1.14e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.52 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 255 LITAFFAGSLALFVLFGVLFYLSDILEKppYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTV 334
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAAD--LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR--RRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 335 ALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISH-RI 413
Cdd:COG2814 88 GSLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwRW 165
|
170 180
....*....|....*....|.
gi 518364731 414 VFISVASMALLTLAFVFFLIK 434
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
68-429 |
1.23e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 68 VPVL-PDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAgivAGLGAVWNSYAILIVGR 146
Cdd:cd17475 15 IPALaPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAA---ALLMALVGSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 147 AIQGLGAAGtapiAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV-----WHAAFFAFPVFCLLSLLAV 221
Cdd:cd17475 92 FLVGAGYGS----VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLalhygWRAAFVVAGLVSILAAVLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 222 VFLLKEPKKTK-EPPKLGEYMRQIGAILKEKGSWLItaFFAGSLALFVLFGVLFYLSdILEKPPYSIDGVMKGFVLAIPL 300
Cdd:cd17475 168 WLFYREPPAASaATESASTLLRSLKEVLRNRDVWLI--AIAGALLVAPQFALLTFLL-LFLHDHLGLSVVAAGALLAVAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 301 LGQVVTSYTTGANIKKNGTLMRWLMNIGLTLMTVALSLCI-FLYDKNIYLFIGLLT----LSSIG-SGLLLpclnTMIAG 374
Cdd:cd17475 245 LGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLsLLSPGTPLWLLVLLLillgLFAIGwNGLYL----TLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 518364731 375 SVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDISH--RIVFISVASMALLTLAFV 429
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHsyAPAWLALALLLVLAALLL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
293-436 |
1.55e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.05 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 293 GFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMI 372
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGR--KRLLLLGLLLLAVSTLLFAFA--TSYWQLLLARFLQGLASAAVWPAAMALI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518364731 373 AGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAFVFFLIKPK 436
Cdd:cd17325 110 ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLLPEP 174
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-222 |
1.79e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.03 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 43 AKGHLWEFIAIASVPLVLVL----GNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIP 118
Cdd:cd17477 179 ESISLRRLLRIAPLALLGAFvagfLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLG 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 119 SLIIygAAGIVAGLGAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLL 198
Cdd:cd17477 259 CALL--GALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
170 180
....*....|....*....|....
gi 518364731 199 ALIVWHAAFFAFPVFCLLSLLAVV 222
Cdd:cd17477 337 MDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
65-433 |
2.07e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 55.72 E-value: 2.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 65 SMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAgiVAGLGAVWNSYAILIV 144
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIP--LLALALAVSSYWGLLV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 145 GRAIQGLGAAGTApIAMALAGDLY----KGGTESKALGLTEAANGTGKVLSPILGSLLALIV----WHAAFFAFPVFCLL 216
Cdd:cd17341 94 LGFLLGFAGANFA-SGQPWASFWFpkekIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGgfvgWRNAFFVPGILLAI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 217 SLLAVVFLLKEPKKTKEPPKlgEYMRQIGAILKEKGSWLITAFFAGSLALFVlfGVLFYLSDILEKPPYSIDGVMKGFVL 296
Cdd:cd17341 173 AAVLVLLFGDDLPTGKASAL--EFLKVQLAVLKNYRTWILSLLYGVTFGSFV--GFSNVLPTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 297 AIPLLGQVVTSYTTGANIKKNGTLMRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAgSV 376
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVP-FI 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 518364731 377 ERDQRGMITSIYNSLRFLGVAFGPPLFSWmmdiSHRIVFISVASMALLTLAFVFFLI 433
Cdd:cd17341 328 FRRELGAVTGLVGAIGGLGGFFLPLLFGS----SALMTGSGVGAFSLFGVLAVACTL 380
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
61-399 |
2.62e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 56.10 E-value: 2.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 61 VLGNSMIVPVLPDIREKLGVSQfQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGlgaVWNSYA 140
Cdd:cd06179 11 LFGVTLPAAVLPFIVADLGPSS-NSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG---TAKSVN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 141 ILIVGRAIQGLGaAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV---WHAAFFAFPVFCLLS 217
Cdd:cd06179 87 MLIGGQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaagWRWIFYINAIFNALA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 218 LLAVVFLLKEPK-KTKEPPKLGEYMRQ---IGAILKEKGSWLIT------------------AFFAGSLALFVLFGV--L 273
Cdd:cd06179 166 LILLFFFYHPPPrPQLHGSSTRQKLKRldwVGLFLLIAGLVLFLlglswggnpypwssahviAPLVIGGVLLIAFGLyeW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 274 FYLSDILEKPPYSIDG------VMKGFVLAIPLLGQVV-----TSYTTGANIKKNGTL---------------------- 320
Cdd:cd06179 246 KGTKDGLLPPRLLFRGrnfaliLIVAFVEGMIFYSLNIfwpqqISLLFTTDPLKAGLYqlpfglgtlfgailagllltki 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 321 --MRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAF 398
Cdd:cd06179 326 khIKWQLVAGFVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAV 405
|
.
gi 518364731 399 G 399
Cdd:cd06179 406 G 406
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
22-225 |
4.75e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 4.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 22 YEATGQAKAKRPKSKNEAGTGAKGHLWEFIAIASVplvLVLGN-SMIVPVLpdIREKLGVSQFQSSLVITLFSVTAGLVI 100
Cdd:cd17370 177 VKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVAL---FALGNfSFAFLIL--RAQELGLSAALIPLLYALFNLVYALAA 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 101 PVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLT 180
Cdd:cd17370 252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALG---SSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF 328
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 518364731 181 EAANGTGKVL-SPILGSLLALIVWHAAFfafpVFC-LLSLLAVVFLL 225
Cdd:cd17370 329 NTVVGIGWLLaSLIAGYLWDLISPSAAF----LFSaVLALIALLLLL 371
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
53-237 |
1.03e-07 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 53.87 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 53 IASVPLVLV--LGNSMIVPVLPDIREKLGVSQFQsslVITLFSV-TAGLV--IPVSGYLSDRFSRKAIIIPSLIIYGAAG 127
Cdd:PRK10473 6 LCSFALVLLypAGIDMYLVGLPRIAADLNASEAQ---LHIAFSVyLAGMAaaMLFAGKIADRSGRKPVAIPGAALFIIAS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 128 IVAGLGAvwnSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLAL-IVWHAA 206
Cdd:PRK10473 83 LLCSLAE---TSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLkFPWQSL 159
|
170 180 190
....*....|....*....|....*....|.
gi 518364731 207 FFAFPVFCLLSLLAVVFLLKEPKKTKEPPKL 237
Cdd:PRK10473 160 FYTMAAMGILVLLLSLFILKETRPARAPAAS 190
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
74-234 |
1.16e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 53.73 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 74 IREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAgiVAGLGAVWNSYAILIVGRAIQGLGA 153
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG--LLLLALALGSLWLFLVLFLLLGLAL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 154 AGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALI--VWHAAFFAFPVFCLLSLLAVVFLLKEPKKT 231
Cdd:COG2223 310 GGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
...
gi 518364731 232 KEP 234
Cdd:COG2223 390 AAA 392
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
58-405 |
1.89e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.71 E-value: 1.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAgiVAGLGAVWN 137
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA--LALIFATPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 138 SYAILIVGrAIQGLGAAGTAPIAMALAGDLYKGGTESkALGLTEAANGTGKVLSPILGSLL--ALIVWHAAFFAFPVFCL 215
Cdd:cd17333 84 IYLFVVLM-FLAGLGAGILDTGANTFVGALFEESSAT-RLNVLHGFFGLGALIGPLIATSLltSELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 216 LSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGswlitaFFAGSLALFVLFGVLFYLSDILEKPPYSIDGVMKGFV 295
Cdd:cd17333 162 LLAILILLTLFPELPSARNPQQSVGAFSASASRLLRN------PSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 296 LAIPLLGQVVTSYTTG----ANIKKNGTLMRWLMNIGLTLMtvaLSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTM 371
Cdd:cd17333 236 LAGYLLSGFWVGITIGrllgGPISRRIKPHTLLVLSGSGAL---LGLLILLLAPTLVVGLVATALLGLFMAALFPTILSL 312
|
330 340 350
....*....|....*....|....*....|....
gi 518364731 372 IAGSVERdQRGMITSIYNSLRFLGVAFGPPLFSW 405
Cdd:cd17333 313 GISNLPY-AKGKGTSVLLAAGSIGGAIIPFIMGF 345
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
66-400 |
3.53e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.84 E-value: 3.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 66 MIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSliiYGAAGIVAGLGAVWNSYAILIVG 145
Cdd:cd17331 18 LQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLS---FLSSALSYLLLAFASSVPMLFLS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 146 RaIQGLGAAGTaPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIV--WHAAFFAFpVFCLLSLLAVVF 223
Cdd:cd17331 95 R-LPSVFMHAM-QAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFgeQAAALVAA-VGSLLSIVLVIL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 224 LLKEPKKTKE--------PPKLGEYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLF--YLSDILEKPPYSIdgvmkG 293
Cdd:cd17331 172 LIPSNTKSKRekeakesaSPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFslVAMDFFGLTPEEN-----G 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 294 FVLA-IPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLYdkNIYLFIGLLTLSSIGSGLLLPCLNTMI 372
Cdd:cd17331 247 YLMSyAGVLGMVVQGLLVGPLTKRFGE--RSLLKLSVALLAIGYLLLAFVT--TVWQLLVLLLPLVIGGSVLYTVITSLL 322
|
330 340
....*....|....*....|....*...
gi 518364731 373 AGSVERDQRGMITSIYNSLRFLGVAFGP 400
Cdd:cd17331 323 TKAVPPEDTGTALGLSHALFSLVRTVSP 350
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
71-272 |
4.35e-07 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 52.36 E-value: 4.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 71 LPDIREKLGVSQfQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIyGAAGIVAGLGAvwNSYAILIVGRAIQG 150
Cdd:pfam06609 67 LPNILQDIGQSE-NQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHII-GLVGAIVGCTA--NKFNTLLAAMTLLG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 151 L--GAAGTAPIamaLAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALI-VWHAAFFAFPVFCLLSLLAVVFLLKE 227
Cdd:pfam06609 143 VaaGPAGASPL---FIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQgNWRWIFYIYIIMSAIAVLLIIIWYHP 219
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518364731 228 P-------KKTKEPPKLGEyMRQIGAILKEKG--------SW---------------LITAfFAGSLALFVLFGV 272
Cdd:pfam06609 220 PsfaqlhgKKARKRDELAK-LDWIGIFLVIAGtslfllgvSWggkpnnpwnsakiigLISS-GAGSLVIFALYEV 292
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
72-248 |
5.22e-07 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 51.65 E-value: 5.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 72 PDIREKLGVSQFQSSLVITLFS-VTAGLVIPVsGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIVGRAIQG 150
Cdd:PRK14995 30 PTLSMTLGASGNELLWIIDIYSlVMAGMVLPM-GALGDRIGFKRLLMLGGTLFGLASLAAAFS---PTASWLIATRALLA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 151 LGAAGTAPIAMALAGDLYkggTESK----ALGLTEAANGTGKVLSPILGS-LLALIVWHAAFFA-FPVFCLLSLLAVVFL 224
Cdd:PRK14995 106 IGAAMIVPATLAGIRATF---TEEKqrnmALGVWAAVGSGGAAFGPLVGGiLLEHFYWGSVFLInVPIVLVVMGLTARYV 182
|
170 180
....*....|....*....|....
gi 518364731 225 LKEPKKTKEPPKLGEYMRQIGAIL 248
Cdd:PRK14995 183 PRQAGRRDQPLNLGHALMLIVAIL 206
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
202-410 |
9.87e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 50.68 E-value: 9.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 202 VWHAAFFAFPVFCLLSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKG-SWLITAFFAGSLALFVLFGVL-FYLSDI 279
Cdd:cd17332 172 YFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPfLILLLAYLLYFLAFNIVNTVLvYYFKYV 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 280 LEKPPYSIdgvmkgFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSI 359
Cdd:cd17332 252 LGGRAELV------LLLLLILSGALLALLPWPPLKKRFGK--KKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGI 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 518364731 360 GSGLLLPCLNTMIAGSVERDQ-------RGMITSIYNSLRFLGVAFGPPLFSWMMDIS 410
Cdd:cd17332 324 GYGGANLLPWAMLADVIDYGElktgkrrEGIFYSVMTFFRKLGLALAGALVGLILSLA 381
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
69-431 |
1.19e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 50.27 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 69 PVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIyGAAGIVAglgAVWNSYAILIVGRAI 148
Cdd:cd17339 20 PLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLL-LAAGILL---RSLGGIALLFLGTAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 149 QGLGAAgtapIAMALAGDLYKGGTESKALGLTeAANGTGKVLSPILGSLLALIVWHAAFF----AFPVFCLLSLLAVVFL 224
Cdd:cd17339 96 AGAGIA----VGNVLLPSLIKRDFPRRVGLMT-GLYTTSMNLGAALASGLSVPLAQALGGgwrgALAIWALPALLALLIW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 225 LKEPKKTKEPPKLGEYMRQIGaILKEKGSWLITAFFAG-SLALFVLFGvlfYLSDILEKppYSIDGVMKGFVLAIPLLGQ 303
Cdd:cd17339 171 LPQLRRRKRAAAAAAPLTKIS-VWRSPLAWQVTLFMGLqSLLFYTLMA---WLPTILID--AGLSAATAGWLLSLFQLVG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 304 VVTSYTTGANIKKngTLMRWLMNIGLTLMTVAlSLCIFLYDKNIYLFIGLLTLsSIGSGLLLPCLNTMIA-GSVERDQRG 382
Cdd:cd17339 245 IPASLLVPILATR--LKNQRPIVVLLAVLFII-GVLGLLFAPTALALLWAVLL-GLGGGAAFSLALTLISlRSSDPAEAA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 518364731 383 MITSIYNSLRFLGVAFGPPLFSWMMDISHRIVfISVASMALLTLAFVFF 431
Cdd:cd17339 321 ALSGMAQSVGYLLAALGPLLFGVLHDLTGSWT-APLVLLLALTVLQLVA 368
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
70-228 |
1.88e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 49.61 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 70 VLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAILIVGRAIQ 149
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA---QNYWQLLILRALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 150 GLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLL-----ALIVWHAAFFaFPVFCLLSLLAVVFL 224
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfpllpPEIAWRVLFL-LGALPALLVLFIRRF 176
|
....
gi 518364731 225 LKEP 228
Cdd:cd17371 177 VKEP 180
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
58-429 |
2.23e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.48 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRF-SRKAIIIPSLIiygaAGIVAGLGAVW 136
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVgHIRAFAAGAAI----TAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 137 NSYAILIVGRAIQGLGAAGTAPIA----MALAGDLYKGgtesKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFpV 212
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSeswlNALATNENRG----RVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAA-V 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 213 FCLLSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLFYLSDILekppysidgvmK 292
Cdd:cd17477 157 LLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQ-----------A 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 293 GFVLAIPLLGQVVTSYTTGANIKKNGTlmRWLMnIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMI 372
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDR--RRVL-LGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 518364731 373 AGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDI-SHRIVFISVASMALLTLAFV 429
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAfGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
78-225 |
3.13e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.14 E-value: 3.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 78 LGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILIVGrAIQGLGAAGTA 157
Cdd:cd17316 208 LGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLL-FILSFFVGGVW 286
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518364731 158 PIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFpVFCLLSLLAVVFLL 225
Cdd:cd17316 287 GALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL-ILALLAIVALIVAL 353
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
66-426 |
4.97e-06 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 48.39 E-value: 4.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 66 MIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAgivAGLGAVWNSYAILIVG 145
Cdd:PRK12307 36 LIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVG---TGLSGLASGVIMLTLS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 146 RAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSP-ILGSLLALIVWHAAFFafpvFCLLSLLAVVFL 224
Cdd:PRK12307 113 RFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAyFMPSFAEAYGWRAAFF----VGLLPVLLVIYI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 225 LKEPKKTKEppklgeymrQIGAILKEKGSWLITAFFAGSLA-------------------LFVLFGVLFYLSDILekPPY 285
Cdd:PRK12307 189 RARAPESKE---------WEEAKLSGKGKHSQSAWSVFSLSmkglfnraqfpltlcvfivLFSIFGANWPIFGLL--PTY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 286 ----SIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMTVALSLCIFLYDKNiYLFIGL----LTLS 357
Cdd:PRK12307 258 lageGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIG--LKKTFSIGLLMSFLFIFPLFRIPQDN-YLLLGAclfgLMAT 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518364731 358 SIGSGLLLPclnTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWM---MDISHRIVFISVASMALLTL 426
Cdd:PRK12307 335 NVGVGGLVP---KFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLgitMGLGAALTFIVAFWTATILL 403
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
62-432 |
6.02e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.39 E-value: 6.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 62 LGNSMIVPVLpdirEKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDR----FSRK----------AIIIPSLIIYGAA- 126
Cdd:cd17313 17 LENSYVPPIL----QTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRrpfilvgaplAALGLILIPNAADi 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 127 GIVAGLGAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHA- 205
Cdd:cd17313 93 GLALGDGPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGf 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 206 --------AFFAFPVFCLLSLLAVVFLLKEPKKTKEPPklgeYMRQIGAILKEKGSWLITAFFAGSLALFVLFGVLF--- 274
Cdd:cd17313 173 alggnlkvPFYIGAIILLVCVLVTLFFVKEPPLSPEAG----EHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFwwi 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 275 -----------------YLSDILEKPPYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGTLMRWLmnIGLTLMTVALS 337
Cdd:cd17313 249 affpfelfftdymgeevYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYL--IGLVLFAVGMA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 338 LCIFLydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQR--GMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVF 415
Cdd:cd17313 327 LMALV--HNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTV 404
|
410
....*....|....*..
gi 518364731 416 ISVAsMALLTLAFVFFL 432
Cdd:cd17313 405 FPVA-AVASFLSLVGAL 420
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
66-238 |
1.50e-05 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 46.80 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 66 MIVPVLPDIREklgvsqfQSSLVITLFSVTAG---LVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavwNSYAIL 142
Cdd:cd17384 18 VVVPIIPDYLN-------ENVRVGLLFASKALvqlITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFG---ESYGVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 143 IVGRAIQGLGAAGTAPIAMALAGDLYKGGTE-SKALGLTEAANGTGKVLSPILGSLLALIVWHAA-FFAFPVFCLLSLLA 220
Cdd:cd17384 88 FLARALQGVGSACSSVAGMGMLASLYPDDKErGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSApFLILAFLALLDGAL 167
|
170
....*....|....*...
gi 518364731 221 VVFLLKePKKTKEPPKLG 238
Cdd:cd17384 168 QLFILQ-PSVKSEESEEG 184
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
47-224 |
1.77e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.83 E-value: 1.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 47 LWEFIAIASVPLVLVLGNSMIVPvlpdiREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIygAA 126
Cdd:cd17353 218 LWLMFFLNATAGLMLIGQAKPIG-----QEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLI--QG 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 127 GIVAGLGAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYkgGTESKAL--GLTEAANGTGKVLSPIL-GSLLALIVW 203
Cdd:cd17353 291 VAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFF--GTKNAGTnyGLLYTAKGVGGLIGPIIaAYVLYTGGY 368
|
170 180
....*....|....*....|.
gi 518364731 204 HAAFFAFPVFCLLSLLAVVFL 224
Cdd:cd17353 369 NAAFIIAAALSLVALALALLL 389
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
81-225 |
1.90e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.42 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 81 SQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAvwnSYAILIVGRAIQGLGAAGTAPIA 160
Cdd:cd17317 23 RDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP---SYELFLVLRFLVGVTSAGIFTVG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518364731 161 MALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSL------LALIV-WHAAFFAFPVFCLLSLLAVVFLL 225
Cdd:cd17317 100 FVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLirdwrwLQLAIsLPGLLFLLLLWWLPRRTIIVGLI 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
50-226 |
2.17e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 50 FIAIASVPLVLVLGNSMIVPVLP-DIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGI 128
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 129 VAGLgAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDL-----YKGG--TESKALGLTEAANGTGKVLSPIL-GSLLAL 200
Cdd:COG2211 310 LLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydeWKTGrrREGLYFGIFTFAIKLGQALAGALaGLLLAL 388
|
170 180 190
....*....|....*....|....*....|....*...
gi 518364731 201 I------------VWHAAFFAFPVFCLLSLLAVVFLLK 226
Cdd:COG2211 389 FgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
258-436 |
2.30e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.27 E-value: 2.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 258 AFFAGSLALFVLFGVLFYLSDILEKppYSIDGVMKGFVLAIPLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMtvALS 337
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS--FGLSASQLGLLFALFSLGYALLQPLAGLLADRFG--RRPVLLLGLLLF--ALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 338 LCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWMMDI---SHRIV 414
Cdd:cd06174 75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAV 154
|
170 180
....*....|....*....|..
gi 518364731 415 FISVASMALLTLAFVFFLIKPK 436
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDP 176
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
86-229 |
2.58e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 46.49 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 86 SLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILIVGRAIQGLGAAgtapIAMALAG 165
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACG----LSTGFVP 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518364731 166 DLYKGGTESKALGLTEAANGTGKVLSPILGSLLAL-------IVWHAAFFAFPVFCLLSLLAVVFLLKEPK 229
Cdd:cd17357 128 MYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLpsvlgteTLWPYLLFFPGIPALLQLAALPFFPESPK 198
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
70-241 |
2.65e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.21 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 70 VLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIvaGLGAVwNSYAILIVGRAIQ 149
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNL--FFGFS-TSLWVMAALWALN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 150 GLGAAGTAPIAMALAGDLYKGGTESKALG-LTEAANGTGKVLSPILGSLLALIV-WHAAFFAFPVFCLLSLLAVVFLLKE 227
Cdd:TIGR00881 94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSfWNCSHNVGGGLLPPLVLFGIAELYsWHWVFIVPGIIAIIVSLICFLLLRD 173
|
170
....*....|....
gi 518364731 228 PKKTKEPPKLGEYM 241
Cdd:TIGR00881 174 SPQSCGLPPAEEMP 187
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
75-231 |
3.04e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 75 REKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIiipsLIIYGAAGIVAGLGAVW-NSYAILIVGRAIQGLGA 153
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL----LRLSALLAAVGLLLALLaPGPWLALIGLALVGLGL 313
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518364731 154 AGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFCLLSLLAVVFLLKEPKKT 231
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
27-223 |
3.56e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.98 E-value: 3.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 27 QAKAKRPKSKNEAGTGAKGHLWEFIAIASVPLV-LVLGNSMIVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGY 105
Cdd:cd17369 207 RAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAeNVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGW 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 106 LSDRFSRKaiiiPSLIIYGAAGIVAGLGAVW-----NSYAILIVGRAIQGLGAAGTAPIAMALAGDLYkgGTESKALGLt 180
Cdd:cd17369 287 LSDRVGRR----PVYLAGALLAALFAFPFFWlldtgSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELF--PTRVRYTGA- 359
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 518364731 181 eaanGTGKVLSPILGSLLALIV----------WHAAFFAFPVFCLLSLLAVVF 223
Cdd:cd17369 360 ----SLGYQLGAILGGGFAPLIatalvaatgsWWPVALYLAALAVISLVAALF 408
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
70-222 |
4.94e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.27 E-value: 4.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 70 VLPDIREKLGVSQFQSSLVIT--LFSVTAGLVipVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILivgRA 147
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSaaLFGMAIGAL--LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL---RF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518364731 148 IQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPVFCLLSLLAVV 222
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIpAFGWRSVFLLGGVPPLILLPLLR 171
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
70-228 |
5.44e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.04 E-value: 5.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 70 VLPDIREKLGVS--QFQSSLVITLFSVTAGLVipVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAvwnSYAILIVGRA 147
Cdd:TIGR00895 39 AAPAISAEWGLDpvQLGFLFSAGLIGMAFGAL--FFGPLADRIGRRRVLLWSILLFSVFTLLCALAT---NVTQLLILRF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 148 IQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGS-LLALIVWHAAFFAFPVFCLLSLLAVVFLLK 226
Cdd:TIGR00895 114 LAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGwLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
..
gi 518364731 227 EP 228
Cdd:TIGR00895 194 ES 195
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-224 |
9.10e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.48 E-value: 9.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 41 TGAKGHLWEFIAIASVPLV--LVLGNSMIVPVL--------PDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRF 110
Cdd:cd17319 163 EGLLGLLLAVLWWFYLRQVwgLALGYFGINYALyglltwlpTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 111 SRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILIVGRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVL 190
Cdd:cd17319 243 LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFV 322
|
170 180 190
....*....|....*....|....*....|....*.
gi 518364731 191 SPILGSLL--ALIVWHAAFFAFPVFCLLSLLAVVFL 224
Cdd:cd17319 323 APLLIGYLvdATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
76-433 |
1.24e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 44.22 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 76 EKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILIVGRAIQGLGAAG 155
Cdd:pfam13347 26 DVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFTPPELGRAPLFIWLLATYI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 156 TAPIAM--------ALAGDLYKGGTE-SKALGLTEAANGTGKVLSPILGSLLALIV---------WHAAFFAFPVFCLLS 217
Cdd:pfam13347 106 LLRIAYtffeipywSLGPELTRDYDErTSLTSYRSFFSVGGGLLAAALAFPLVLILggtglerkgYRIFALIGAVLMLLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 218 LLAVVFLLKEPKKTKEPPKL-----GEYMRQIGAILKEKGS-WLITAFFAGSLALFVLFG-VLFYLSDILEKP---PYSI 287
Cdd:pfam13347 186 VIITAAGTKERVSMRSKEDTgqkeaGSLLDMLKEVFRNRAFlILLASFLLAALAMGVLNGlLLYYFRYVLGNGfaaSAFP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 288 DGVMKGFVLAIPLLGQVVTSYTtganiKKNGTLmrwlmnIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPC 367
Cdd:pfam13347 266 LVFTIGALLGIPLWPPLAKRIG-----KKNTYI------LGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFL 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518364731 368 LNTMIAGSVERDQ-------RGMITSIYNSLRFLGVAFGPPLFSWMMDISHRIVFISVAS-MALLTLAFVFFLI 433
Cdd:pfam13347 335 PWSMLADVVDYGElrtgkrrEGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSpQAVTAIRLLYAVL 408
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
56-198 |
1.50e-04 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 43.84 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 56 VPLVLVLGNSM---IVPVLPDIRE---KLGVsQFQSSLVITLfsvtagLVIPVSGYLSDRFSrkaIIIPSLIIYGAAGIV 129
Cdd:cd17383 4 VCIALLLDNMLymvIVPIIPDYLNediAIGV-LFASKAIVQL------LVNPFSGTLIDRVG---YDIPMMIGLTVMFLS 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518364731 130 AGLGAVWNSYAILIVGRAIQGLGA--AGTAPIAMaLAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLL 198
Cdd:cd17383 74 TAVFAFGESYAVLFFARSLQGVGSafADTAGLAM-IADRFTEEAERSKALGIALAFISFGCLVAPPFGGIL 143
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
71-235 |
1.51e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 43.75 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 71 LPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAvwNSYAILIVGRAIQG 150
Cdd:cd17353 26 NPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAI--SLPLLFLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 151 LGAAGTAPIAMALAGDLY---KGGteskALGLTEAANGTGKVL-SPILGSLLALIVWHAAFFAFPVFCLLSLLAVVFLLK 226
Cdd:cd17353 104 IGAGIGYITPVSTAVKWFpdkRGL----ATGIVIAGFGLGSLIfSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIR 179
|
....*....
gi 518364731 227 EPKKTKEPP 235
Cdd:cd17353 180 DPPKGWVPP 188
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
70-432 |
1.60e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 70 VLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIpsliiygAAGIVAGLGAVWNSYA------ILI 143
Cdd:cd17352 25 LFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAI-------AGGLLAALGLLLSSFAtslwqlYLT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 144 VGrAIQGLGAA-GTAPIAMALAGDLYKggTESKALGLTEAANGTGK-VLSPILGSLLALIVWHAAFFAFPVFCLLSLLAV 221
Cdd:cd17352 98 YG-VLGGLGLGlIYSPAIVIVGQYFEK--KRGLATGIAVAGSGVGTfVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 222 VFLlkepkktkeppklgeymrqigAILKEKGSWLItaFFAGSLALFVLFGVLFYLSDILEKPPYSIDGVMkgFVLAI--- 298
Cdd:cd17352 175 LLL---------------------RLLKDPTFVLL--ALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAA--FLLSIigi 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 299 -PLLGQVVTSYTtgANIKKNGTLmrWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVE 377
Cdd:cd17352 230 sDIVGRILLGLL--ADKPRIGRL--YLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLE 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 378 RdqrgmITSIYNSLRF---LGVAFGPPLFSWMMDISH--RIVFISVASMALLTLAFVFFL 432
Cdd:cd17352 306 K-----LSNAYGLVLLfqgLAALVGPPIAGLLRDYTGdyDAAFYFCGACLLLSGVLLFLL 360
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
65-227 |
1.77e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.76 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 65 SMIVPVLPDIREKLGVS-----QFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIiyGAAGIVAGLGAVWNSY 139
Cdd:PRK09874 31 SLVMPFLPLYVEQLGVTghsalNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSAL--GMGIVMVLMGLAQNIW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 140 AILIVgRAIQGLgAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA-LIVWHAAFFAFPVFCLLSL 218
Cdd:PRK09874 109 QFLIL-RALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAdSYGLRPVFFITASVLFLCF 186
|
....*....
gi 518364731 219 LAVVFLLKE 227
Cdd:PRK09874 187 LVTLFCIRE 195
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
322-441 |
2.25e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.13 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 322 RWLMNIGLTLmtVALSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPP 401
Cdd:TIGR00881 60 RVFLPIGLIL--CAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPP 137
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 518364731 402 --LFSWMMDISHRIVFISVASMALLTLAFVFFLIKPKGQLSG 441
Cdd:TIGR00881 138 lvLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCG 179
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
71-159 |
3.10e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 42.80 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 71 LPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSyaiLIVGRAIQG 150
Cdd:PRK10504 33 LPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNE---LLLARVLQG 109
|
....*....
gi 518364731 151 LGAAGTAPI 159
Cdd:PRK10504 110 VGGAMMVPV 118
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
71-224 |
3.70e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.57 E-value: 3.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 71 LPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIpsLIIYGAAGIVAGLGAVWNSYAILIVGRAIQG 150
Cdd:cd17365 194 LPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLA--LFFALGAVSLALLGVSPASLVLLYVLVFLAG 271
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 151 LGAAGTAPIAMALAGDLYkgGTESKALGLTeAANGTGK---VLSPILGSLLALIVWHAA--FFAFPVFCLLSLLAVVFL 224
Cdd:cd17365 272 ACVNGAQVGLYALAARFY--PTEVRATGVG-WALGVGRlgaILGPLLGGLLLAAGLGPEsvFLALAIPAALGALAVLLL 347
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
58-225 |
4.24e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.25 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 58 LVLVLGNSMIVPVLPDIREKLGVSQ----FQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIygAAGIVAGLG 133
Cdd:cd17391 211 FIIQLANQSIEPILTLYIRQLMGDAsnlaFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLA--SALLYIPQA 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 134 AVWNSYAILIVgRAIQGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLL-ALIVWHAAFFafpV 212
Cdd:cd17391 289 FVQTPWQLGIL-RFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVFV---V 364
|
170
....*....|...
gi 518364731 213 FCLLSLLAVVFLL 225
Cdd:cd17391 365 TALLVLLNAIWSF 377
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
69-229 |
4.75e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.26 E-value: 4.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 69 PVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLG-AVWNSYAILIVGRA 147
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFStSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 148 IQGLGAAGtapiAMALAGDLYKGGTESKALGLTEAANGTGKVLSPIL-GSLLALIVWHAAFFAFPVFCLL-SLLAVVFLL 225
Cdd:cd17312 104 FQSMGWPP----CVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILaASLASYYGWRAAFLVPGIVGLVvAIILFFFLR 179
|
....
gi 518364731 226 KEPK 229
Cdd:cd17312 180 DSPP 183
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
86-226 |
5.36e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 5.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 86 SLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAgiVAGLGAVWNSYAILIVGrAIQGLGAAGTAPIAMALAG 165
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG--LLLLSFAGSPWMLLLAA-VLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518364731 166 DLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFCLLSLLAVVFLLK 226
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
84-160 |
5.40e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.26 E-value: 5.40e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 84 QSSLVITLFSV--TAGLVIpvSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILIVGRAIQGLGAAGTAPIA 160
Cdd:pfam00083 47 LSGLIVSIFSVgcFIGSLF--AGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLA 123
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
67-433 |
5.82e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.80 E-value: 5.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 67 IVPVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFS-RKAIIIPSLIiyGAAGIVAGLGAVWNSYAILIVG 145
Cdd:cd17335 16 LLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLL--AAVLFFLSLFFVAQIFWLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 146 RAIQGLGAAGTAPIAMALAGDLYKGGTES-------KALGLTEAANGTGKVlspiLGSLLALIVWHAAFFAFPVFCLLSL 218
Cdd:cd17335 94 VILGAFFSAPVVPLVDSITLQYLGEERERygkqrlwGSIGFGIAALLVGIL----IDRSSTYKNYTIAFYVFAVLMLLAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 219 LAVVFLLKEPKKTKEPPKLGeymrQIGAILKEKGSW--LITAFFAG-SLALFVLFGVLFylsdiLEKPPYSidGVMKGFV 295
Cdd:cd17335 170 LLALKFPFRPKHPEPNENTG----GLLALLRNPRVLafLLVAFLMGfGHGLIYSFLFWH-----LQDLGGS--KTLIGLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 296 LAIPLLGQVVTSYTTGANIKKNGtlMRWLMNIGLTLMTValSLCIFLYDKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGS 375
Cdd:cd17335 239 WTVGVVSEIPFFFFSSRLIQRFG--HVGLLYLGLLAYVV--RWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 376 VERDQRGMITSIYNSLRF-LGVAFGPPLFSWMMD-ISHRIVFISVASMALLTLAfVFFLI 433
Cdd:cd17335 315 APPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEaFGARTTFRFFAIAALAGLL-AFFLI 373
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
83-163 |
5.88e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 5.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 83 FQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILivgRAIQGLGAAGTAPIAMA 162
Cdd:TIGR00898 127 WKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF---RLLVGMGIGGIWVQAVV 203
|
.
gi 518364731 163 L 163
Cdd:TIGR00898 204 L 204
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
322-437 |
6.03e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 322 RWLMNIGLTLMTVALSLCIFLYdkNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNSLRFLGVAFGPP 401
Cdd:COG0477 79 KRVLLIGLLLFGLASLLCGLAP--SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156
|
90 100 110
....*....|....*....|....*....|....*..
gi 518364731 402 LFSWMMD-ISHRIVFISVASMALLTLAFVFFLIKPKG 437
Cdd:COG0477 157 LGGLLVAaLGWRWIFLINAPLGLLALVLRLRLPESRG 193
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
293-432 |
1.08e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 293 GFVLAIPLLGQVVTSYTTGANIKKNGtlMRWLMnIGLTLMTVALSLCIFLYDkNIYLFIGLLTLSSIGSGLLLPCLNTMI 372
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVG--HIRAF-AAGAAITAVSVLLLALTD-SPWVWFLLRFVMGIGLAGLFVVSESWL 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 373 AGSVERDQRGMITSIYNSLRFLGVAFGPPLFSWmMDISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17477 110 NALATNENRGRVLGLYSTVLGLGFALGPLLLAL-VGTAGALPFLIAAVLLLLALVPLLLT 168
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
78-225 |
1.25e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 78 LGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILIVGRAIQGLGAAGTA 157
Cdd:cd17321 199 LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 158 PIAMALAGDLYKGGTESKALGLTEAANGTGKVLSP-ILGSLLALIV-----------------------WHAAFFAFPVF 213
Cdd:cd17321 279 TPLTNAALSSVPKEKAGAASGILNTARQLGGALGVaLLGALLTAGLsanlgdsgvaallsaaaaafaagFHLAFLVAAAL 358
|
170
....*....|..
gi 518364731 214 CLLSLLAVVFLL 225
Cdd:cd17321 359 ALLAALLALLLP 370
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
94-433 |
1.33e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 41.06 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 94 VTAGLVIP------VSGYLSDRFSRKAIII----PSLIIYGAAGIVAGLGAVWNSYAILivgrAIQGLGAAGTAPIAMAL 163
Cdd:PRK08633 52 VNALFLLPflllssPAGFLADKFSKNRVIRivklFEVGLTLLIVLAYYLGWFWLAFAVT----FLLGAQSAIYSPAKYGI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 164 AGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLA--------LIVWHAAFFAFPVFCLLSLLAVVFLLKEPKKTKEPP 235
Cdd:PRK08633 128 IPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFesvngntpSEILGRIAPAGLVLLAVAVLGLIFAYRLPKVPAAAP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 236 ---------KLGEYMRQIGAILKEKGSWL----ITAF-FAGSLALFVLfgvLFYLSDILekppySIDGVMK-GFVLAIPL 300
Cdd:PRK08633 208 evfdkkkylFPKLLWRNLKLLRSDRVLWLaiigLSYFwFISQLAQANF---PAYAKEVL-----GLDNTFQvQYLLAASA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 301 LGQVVTSYTTGANIKKN---GTLMrwLMNIGLTLMTVALSLCIflydkNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVE 377
Cdd:PRK08633 280 IGIGIGSLLAGRLSGRHielGLVP--LGALGLALSLFLLPTAP-----SLASVLVLFFLFGFSAGLFIVPLNALIQFRAP 352
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 378 RDQRGMITSIYNSLRFLGVaFGPPLFSWM---MDISHRIVFISVASMALLTLAFVFFLI 433
Cdd:PRK08633 353 EKELGKVLAANNFLQNVGM-LLFLALTTLfsgLGLSPAGLFYLIALVTLIGTLYTLLLL 410
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
83-156 |
1.75e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 40.41 E-value: 1.75e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518364731 83 FQSSLVITLFsvTAGLVIpvsGYLSDRFSRKAIIIPSLIIYGAAGIVAglgAVWNSYAILIVGRAIQGLGAAGT 156
Cdd:cd17379 38 FQSSLNLGFL--IGSIVI---GYLADRFGRKVCFLISILGNGVSGVLM---AFSPNYPWFLIFRFLQGLFGKGG 103
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
72-229 |
3.62e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 72 PDIREKLGVSQfqSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGA-------VWNSYaILIV 144
Cdd:pfam00083 278 TTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVAllgvsksDWAGI-VAIV 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 145 GRAI-QGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPIL-GSLLALIVWHAAFFAFPVFCLLSLLAVV 222
Cdd:pfam00083 355 FIALfIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLfPIITDAIGLGYTFFIFAGLLVLFIIFVF 434
|
....*..
gi 518364731 223 FLLKEPK 229
Cdd:pfam00083 435 FFVPETK 441
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
82-399 |
3.72e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 39.73 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 82 QFQSSLVITLFSVtaglvipVSGYLSDRFSRKAIIIPSLIIYGAAG----IVAGLGAVwnSYAILIVGRAIQGLGAAGTA 157
Cdd:pfam05977 51 QAAATLPIFLLSI-------PAGALADNFDRRKIMLAGQLLLALVStlltLLAGLGLL--SPWLLLGLTFLGGIGTALMD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 158 PIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFCLLSLLAVVFLLKE--PKKTKEPP 235
Cdd:pfam05977 122 PAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRWKRaaPASPLPRE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 236 KLGEYMR---QIGAILKEKGSWLI--TAFFAGSLALFVLFGVLfyLSDILEKPPySIDGVMKGFVLAIPLLGQVVTSYTT 310
Cdd:pfam05977 202 RIFGAVRaglRFTAMSRELRSVLVraFAFGLSASAVWALLPLV--ARDLLDGDA-IFYGILLGAVGVGAILGALSLPRLR 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 311 gANIKKNGTLMrwLMNIGLTLMTVALSLCiflydKNIYLFIGLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIYNS 390
Cdd:pfam05977 279 -ERLGSDRLVL--LASVVTALVLLSLALA-----PNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQT 350
|
....*....
gi 518364731 391 LRFLGVAFG 399
Cdd:pfam05977 351 VFFGGMAAG 359
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
74-432 |
3.82e-03 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 39.18 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 74 IREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRF--SRKAIIIPSLIIYGAAGIVAgLGAVWNSYAILIVGRAIQGL 151
Cdd:cd17340 25 FIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDRVfgIRLGTIIFSLLVLIGQLIFA-LGALTNLFWLMLVGRFIFGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 152 GAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTG-----KVLSPILGSL---------LALIVWHAAFFAfpVFCLLS 217
Cdd:cd17340 104 GGESLAVAQNTYAVSWFKGKELNLVFGLQLSFARIGstvnfNVMPPIYKRIsdfysgyksLGVALWIGAITC--LFSLIC 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 218 LLAVVFLLK--EPKKTKEPPKLGEYMRqIGAILKEKGS-WLIT-AFFAGSLALFVLFGV--LFYlsdiLEKPPYSIDGVm 291
Cdd:cd17340 182 AIILGLLDKraERILKKESNKTGEVIK-LSDVKDFPLSfWLICiICVFYYVAVFPFIGLgtVFF----EEKYGFSPSEA- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 292 kGFVLAIPLLGQVVTSYTTGANIKKNGTLMRWLMnIGLTLMTVALSLCIFlydKNIYLFIGLLTLsSIGSGLLLPCLNTM 371
Cdd:cd17340 256 -AAVNSIVYIISAAASPVFGFLVDKVGRNILWVL-IALVITLLGHLLLAF---TFVNPLIAMVIM-GIGYSMLACALWPM 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 372 IAGSVERDQR----GMITSIYNslrfLGVAFGPPLFSWMMD----ISHRIVFISVASMALLTLAFVFFL 432
Cdd:cd17340 330 VPLVVPEHQLgtayGFMQSIQN----LGLAVFPIIAGSILDkkgyLLLEVFFIACLCVSLIALIILYLV 394
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
69-272 |
4.06e-03 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 39.13 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 69 PVLPDIREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGAVWNSYAILIVGRAI 148
Cdd:cd17394 20 ILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALLFIPAASLRTYGLFLIALFV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 149 QGLGAAGTAPIAMALAGDLYKGGTESKALGLTEAANGTGKVLSPILGSLLAL--------------------------IV 202
Cdd:cd17394 100 LASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILsgipstatalaamsaaelqayktaelAS 179
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 203 WHAAFFAFPVFcLLSLLAVVFLLKEPKKTKEPPKLGEYMRQIGAILKEKGSWLitaffaGSLALFVLFGV 272
Cdd:cd17394 180 VQLPYLGIALV-LLLLAVLILLSKLPEIEAAEAEALGSKGTLLRLLKNPHLRL------GVLAIFFYVGA 242
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
74-199 |
5.70e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.77 E-value: 5.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 74 IREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFsRKAIIIPSLIIygAAGIVAGLGAVWNSYAILIVGRAIQGLGA 153
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRF-PPSKWLSVFIV--LWGLLTLLTAAVKNFGGLIALRFFLGLFE 108
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 518364731 154 AGTAPIAMALAGDLYKGGTESKALGLTEAANGtgkvLSPILGSLLA 199
Cdd:cd17327 109 SGVFPGFILYLGMWYKREEQAKRIAFFYAAAG----LGSIFGGLLA 150
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
93-388 |
5.87e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 38.74 E-value: 5.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 93 SVTAGLVIpvsGYLSDRFSRKAiiipSLIIYGAAGIVAGLGAVWNSYAILIVGRAIQGLGAA--GTAPIAMALAGDLYKG 170
Cdd:cd17487 51 SVVFGTFV---GSLADKFGRKR----ACLLFCVLYSLSCLTKHSPNFGVLLLGRVLGGISTSllFSAFESWMVHEHNKRG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 171 GTESKALGLTEAANGTGKVLSPILGSLLALIVWHAAF-FAFP-----VFCLLSLLAVVFLLKEPK-KTKEPPKLGEYMRQ 243
Cdd:cd17487 124 FFPKEWLSTTFSKATLGNGLVAILAGLVANFAEALGFgPVAPfdaaiPFLVLAGVLIMRTWTENYgDPSSPSRLGCQEEA 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 244 IGAILKEKGSWL---ITAFFAGSLALFVLFGVLFYLSDILEKPPYSIdgVMKGFVLAIpLLGQVVTSYTTGANIKKNgtl 320
Cdd:cd17487 204 LRAILSDKKVLLlgaIQSLFESAMYIFVFLWTPALDPAQSGGVPLGI--IFACFMVAM-MIGSSLFRLLLSKRVSPE--- 277
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 321 mrWLMNIGLTLMTVALSLCIFLYDKNIYLFI-GLLTLSSIGSGLLLPCLNTMIAGSVERDQRGMITSIY 388
Cdd:cd17487 278 --HLLVIVLLVASVSLFLPVVSTITSSPKILlLAFLVFEACVGLYFPSMGTLRSKYIPEEHRATVMNLF 344
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
69-363 |
6.17e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.44 E-value: 6.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 69 PVLPD-IREKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKAIIIPSLIIygAAGIVAGLGAVWNSYAILIVGRA 147
Cdd:TIGR00886 22 PLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLL--LAIPCLWAGLAVQSYSVLLLIRL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 148 IQGLGAAGTApIAMALAGDLYKGGTESKALGLTEAANGTG-----KVLSPILGSLLALI--------VWHAAFFAFPVFC 214
Cdd:TIGR00886 100 FIGIAGGSFA-SCMPWISFFFPKKIQGTALGLAAGWGNMGggvaqFVMPPIIGSLIFGGgqpahlawGWAFVIVPAGILL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 215 LLSLLAVVFLLKEPKKTKEPPKLgeYMRQIGAILKEKGSWLITAFFAGSLALFVlfGVLFYLSDILEKPpYSIDGVMKGF 294
Cdd:TIGR00886 179 LPALLIFFVGADTPPGKPATGKL--SFKEALKVFGNRHTWILALLYSVTFGSFL--GVSSIFAMLFKDQ-FGLSKVQAGA 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518364731 295 VLAIPLLGQVVTSYTTGANIKKNGTLMRWLMNIGLTLMTVALSLCIFLYDKNIYLFIGLLTLSSIGSGL 363
Cdd:TIGR00886 254 YASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAGA 322
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
78-159 |
6.22e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 38.71 E-value: 6.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 78 LGVSQFQSSLVITLFSVTAGLVIPVSGYLSDRFSRKaiiiPSLIIYGAAGIVAGLGAVW-NSYAILIVGRAIQGLG---A 153
Cdd:cd17315 29 FGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRR----KSLLIAAVLYVIGALLSALaPNVWVLIVGRFLLGLGvglA 104
|
....*.
gi 518364731 154 AGTAPI 159
Cdd:cd17315 105 SVLVPL 110
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
66-155 |
6.77e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 38.53 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 66 MIVPVLPDIREKLGVSQFQSSLVITLFSVT---AGLVIpvsGYLSDRFSRKAIIIPSLIIYGAAGIVAGLGavWNsYAIL 142
Cdd:PRK03893 38 LITLVLTEVQGEFGLTTVQAASLISAAFISrwfGGLLL---GAMGDRYGRRLAMVISIVLFSVGTLACGFA--PG-YWTL 111
|
90
....*....|...
gi 518364731 143 IVGRAIQGLGAAG 155
Cdd:PRK03893 112 FIARLVIGMGMAG 124
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
76-268 |
7.90e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 7.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 76 EKLGVSQFQSSLVITLFSVTAGLVIPVSGYLSDR-FSRKAIIIPSLIIYGAAGIvaGLGAVWNSYAILIVGRAIQGLGAA 154
Cdd:cd17471 25 EELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYL--LFAFLRNYWVLLLVGVVLLSLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518364731 155 gTAPIAMALAGDLYKGGTESKA---LGLTEAANGTGKVLSPILGSLLALIVWHAAFFAFPVFC-LLSLLAVVFLLKEPKK 230
Cdd:cd17471 103 -AFPQLFALAREYADRSSGRDAtlfNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLyLVVALLVLFLLPSVKP 181
|
170 180 190
....*....|....*....|....*....|....*...
gi 518364731 231 TKEPPKLGEYMRQIGAIlkekgsWLITAFFAGSLALFV 268
Cdd:cd17471 182 PAQKATPASSLVKAPVN------RRLLLLFAAFTLLFA 213
|
|
| |
