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Conserved domains on  [gi|518451005|ref|WP_019621212|]
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Trk system potassium transporter TrkA [Amphritea japonica]

Protein Classification

Trk system potassium transport protein TrkA( domain architecture ID 11484302)

Trk system potassium transport protein TrkA may regulate the transport activity of the constitutive potassium transport TrkG and TrkH systems; binds to NAD(+) and NADH

Gene Ontology:  GO:0006813

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-455 0e+00

Trk system potassium transporter TrkA;


:

Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 658.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005   1 MKIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDRLDIRTVEGKASHPTILDQAGARDADMLIAVTNSDEVNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005  81 VACQIAQTLYHTPTKIARVREHDYLlKKNTIFTDKSIPIDVLISPEELVTKHIHRLIEHPGALQVLDFADGIAQLVAVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEYA-EYDKLFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 161 YYGGPLVGREISYLRSHMPSVETRVAAIFRKGSPIIPKGDTVIEADDEVFFIAAKKDIRSVMSELRRLDRPYKRIIIAGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 241 GNIGARLADKIED-KYQVKIIERDIHRCNSLAKRLNNTIVLQGSASDKELLLEENIEDTDVFCALTNDDEANIMASMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 320 RLGARTVMTLINNPAYVDLVQGGVIDIAISPQQTTIGSLLTHVRRGDVAAVHSLRRGAAEALEAVAHgdsRSSKVVGKMI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 518451005 400 EEIDLPKGTTIGAIVRNDEVLIAHDDVVVENDDHVILFLVDKRKIGEVERLFQVGL 455
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSP 452
 
Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-455 0e+00

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 658.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005   1 MKIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDRLDIRTVEGKASHPTILDQAGARDADMLIAVTNSDEVNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005  81 VACQIAQTLYHTPTKIARVREHDYLlKKNTIFTDKSIPIDVLISPEELVTKHIHRLIEHPGALQVLDFADGIAQLVAVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEYA-EYDKLFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 161 YYGGPLVGREISYLRSHMPSVETRVAAIFRKGSPIIPKGDTVIEADDEVFFIAAKKDIRSVMSELRRLDRPYKRIIIAGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 241 GNIGARLADKIED-KYQVKIIERDIHRCNSLAKRLNNTIVLQGSASDKELLLEENIEDTDVFCALTNDDEANIMASMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 320 RLGARTVMTLINNPAYVDLVQGGVIDIAISPQQTTIGSLLTHVRRGDVAAVHSLRRGAAEALEAVAHgdsRSSKVVGKMI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 518451005 400 EEIDLPKGTTIGAIVRNDEVLIAHDDVVVENDDHVILFLVDKRKIGEVERLFQVGL 455
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSP 452
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 137-435 6.11e-60

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 197.98  E-value: 6.11e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 137 IEHPGALQVLDFADGIAQLVAVKAYYGGPLVGREISYLRSHMPSVETRVAAIFRKGSPIIPKGDTVIEADDEVFFIAAKK 216
Cdd:COG0569    1 LLILLLLLVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 217 DIRSVMSELRRLDRPyKRIIIAGGGNIGARLADK-IEDKYQVKIIERDIHRCNSLAKRlnNTIVLQGSASDKELLLEENI 295
Cdd:COG0569   81 ALRRRRMERGIKKLK-MHVIIIGAGRVGRSLARElEEEGHDVVVIDKDPERVERLAEE--DVLVIVGDATDEEVLEEAGI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 296 EDTDVFCALTNDDEANIMASMLAKRLGARTVMTLINNPAYVDLVQGGVIDIAISPQQTTIGSLLTHVRRGDVAAVHSLRR 375
Cdd:COG0569  158 EDADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELAD 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518451005 376 GAAEALEAVAHGDsrsSKVVGKMIEEIDLPK--GTTIGAIVRNDEVLIAHDDVVVENDDHVI 435
Cdd:COG0569  238 GDAEIVEVTVPEG---SPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 3-125 2.08e-22

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 91.82  E-value: 2.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005    3 IIILGAGQVGGTLAENLaSEANDITIVDTDMGRLRELQDRLdIRTVEGKASHPTILDQAGARDADMLIAVTNSDEVNMVA 82
Cdd:pfam02254   1 IIIIGYGRVGRSLAEEL-SEGGDVVVIDKDEERVEELREEG-VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILI 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 518451005   83 CQIAQTLYHTPTKIARVREHDY--LLKKntiftdksIPIDVLISP 125
Cdd:pfam02254  79 VLLARELNPDKKIIARANDPEHaeLLRR--------LGADHVISP 115
L-AlaDH cd05305
Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) ...
 2-72 1.36e-05

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.


Pssm-ID: 240630 [Multi-domain]  Cd Length: 359  Bit Score: 47.01  E-value: 1.36e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518451005   2 KIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDRLDIRtVEGKASHPTILDQAgARDADMLI-AV 72
Cdd:cd05305  170 KVVILGAGVVGENAARVALGLGAEVTVLDINLERLRYLDDIFGGR-VTTLYSNPANLEEA-LKEADLVIgAV 239
 
Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-455 0e+00

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 658.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005   1 MKIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDRLDIRTVEGKASHPTILDQAGARDADMLIAVTNSDEVNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005  81 VACQIAQTLYHTPTKIARVREHDYLlKKNTIFTDKSIPIDVLISPEELVTKHIHRLIEHPGALQVLDFADGIAQLVAVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEYA-EYDKLFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 161 YYGGPLVGREISYLRSHMPSVETRVAAIFRKGSPIIPKGDTVIEADDEVFFIAAKKDIRSVMSELRRLDRPYKRIIIAGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 241 GNIGARLADKIED-KYQVKIIERDIHRCNSLAKRLNNTIVLQGSASDKELLLEENIEDTDVFCALTNDDEANIMASMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 320 RLGARTVMTLINNPAYVDLVQGGVIDIAISPQQTTIGSLLTHVRRGDVAAVHSLRRGAAEALEAVAHgdsRSSKVVGKMI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 518451005 400 EEIDLPKGTTIGAIVRNDEVLIAHDDVVVENDDHVILFLVDKRKIGEVERLFQVGL 455
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSP 452
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 137-435 6.11e-60

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 197.98  E-value: 6.11e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 137 IEHPGALQVLDFADGIAQLVAVKAYYGGPLVGREISYLRSHMPSVETRVAAIFRKGSPIIPKGDTVIEADDEVFFIAAKK 216
Cdd:COG0569    1 LLILLLLLVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 217 DIRSVMSELRRLDRPyKRIIIAGGGNIGARLADK-IEDKYQVKIIERDIHRCNSLAKRlnNTIVLQGSASDKELLLEENI 295
Cdd:COG0569   81 ALRRRRMERGIKKLK-MHVIIIGAGRVGRSLARElEEEGHDVVVIDKDPERVERLAEE--DVLVIVGDATDEEVLEEAGI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 296 EDTDVFCALTNDDEANIMASMLAKRLGARTVMTLINNPAYVDLVQGGVIDIAISPQQTTIGSLLTHVRRGDVAAVHSLRR 375
Cdd:COG0569  158 EDADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELAD 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518451005 376 GAAEALEAVAHGDsrsSKVVGKMIEEIDLPK--GTTIGAIVRNDEVLIAHDDVVVENDDHVI 435
Cdd:COG0569  238 GDAEIVEVTVPEG---SPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 1-210 1.24e-53

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 181.42  E-value: 1.24e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005   1 MKIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDRlDIRTVEGKASHPTILDQAGARDADMLIAVTNSDEVNM 80
Cdd:COG0569   96 MHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEE-DVLVIVGDATDEEVLEEAGIEDADAVIAATGDDEANI 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005  81 VACQIAQTLyHTPTKIARVREHDYLLKKntiftdKSIPIDVLISPEELVTKHIHRLIEHPGALQVLDFADGIAQLVAVKA 160
Cdd:COG0569  175 LACLLAKEL-GVPRIIARANDPEYADLL------ERLGADVVISPERLAARRIARLLLRPGVLDVLELADGDAEIVEVTV 247

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 518451005 161 YYGGPLVGREISYLRSHMPSvETRVAAIFRKGSPIIPKGDTVIEADDEVF 210
Cdd:COG0569  248 PEGSPLVGKTLKELDLRERY-GVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 3-125 2.08e-22

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 91.82  E-value: 2.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005    3 IIILGAGQVGGTLAENLaSEANDITIVDTDMGRLRELQDRLdIRTVEGKASHPTILDQAGARDADMLIAVTNSDEVNMVA 82
Cdd:pfam02254   1 IIIIGYGRVGRSLAEEL-SEGGDVVVIDKDEERVEELREEG-VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILI 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 518451005   83 CQIAQTLYHTPTKIARVREHDY--LLKKntiftdksIPIDVLISP 125
Cdd:pfam02254  79 VLLARELNPDKKIIARANDPEHaeLLRR--------LGADHVISP 115
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 246-350 2.46e-19

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 83.34  E-value: 2.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005  246 RLADKIEDKYQVKIIERDIHRCNSLAKRLnnTIVLQGSASDKELLLEENIEDTDVFCALTNDDEANIMASMLAKRL-GAR 324
Cdd:pfam02254  12 SLAEELSEGGDVVVIDKDEERVEELREEG--VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILIVLLARELnPDK 89

                          90       100
                  ....*....|....*....|....*.
gi 518451005  325 TVMTLINNPAYVDLVQGGVIDIAISP 350
Cdd:pfam02254  90 KIIARANDPEHAELLRRLGADHVISP 115
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
3-108 2.78e-10

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 60.90  E-value: 2.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005   3 IIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQdRLDIRTVEGKASHPTILDQAGARDADMLIAVTNSDEVNMVA 82
Cdd:COG1226  127 VIIAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELR-RFGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAALRI 205

                         90       100
                 ....*....|....*....|....*...
gi 518451005  83 CQIAQTLYHTPTKIARV--REHDYLLKK 108
Cdd:COG1226  206 VELARELNPDLKIIARArdREHAEELRQ 233
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 392-452 1.90e-09

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 59.74  E-value: 1.90e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518451005 392 SKVVGKMIEEIDLPKGTTIGAIVRNDEVLIAHDDVVVENDDHViLFLVDKRKIGEVERLFQ 452
Cdd:COG3263  424 SPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQL-LVLAPPEDLEALERLFA 483
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 155-225 5.88e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 49.53  E-value: 5.88e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518451005  155 LVAVKAYYGGPLVGREIS--YLRSHMpsvETRVAAIFRKGSPIIPKGDTVIEADDEVFFIAAKKDIRSVMSEL 225
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKelNLPERF---GVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
PRK05326 PRK05326
potassium/proton antiporter;
153-226 2.01e-07

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 53.28  E-value: 2.01e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518451005 153 AQLVAVKAYYGGPLVGREISYLRshMPSvETRVAAIFRKGSPIIPKGDTVIEADDEVFFIAAKKDIRSVMSELR 226
Cdd:PRK05326 414 AELLEYRVPAGSWLVGKALRDLR--LPR-GALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALERLFS 484
PRK05326 PRK05326
potassium/proton antiporter;
392-452 9.92e-07

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 50.97  E-value: 9.92e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518451005 392 SKVVGKMIEEIDLPKGTTIGAIVRNDEVLIAHDDVVVENDDHVILfLVDKRKIGEVERLFQ 452
Cdd:PRK05326 425 SWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLV-LGPERDLPALERLFS 484
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 391-451 1.32e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 45.68  E-value: 1.32e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518451005  391 SSKVVGKMIEEIDLPK--GTTIGAIVRNDEVLIAHDDVVVENDDHVIlFLVDKRKIGEVERLF 451
Cdd:pfam02080   9 NSPLVGKTLKELNLPErfGVRIVAIRRGGRLIIPSGDTVLEAGDRLL-VIGTPDDLAALRELL 70
Ald COG0686
Alanine dehydrogenase (includes sporulation protein SpoVN) [Amino acid transport and ...
 2-72 4.86e-06

Alanine dehydrogenase (includes sporulation protein SpoVN) [Amino acid transport and metabolism]; Alanine dehydrogenase (includes sporulation protein SpoVN) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440450 [Multi-domain]  Cd Length: 372  Bit Score: 48.47  E-value: 4.86e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518451005   2 KIIILGAGQVGgtlaENLASEA----NDITIVDTDMGRLRELQDRLD--IRTVegkASHPTILDQAgARDADMLI-AV 72
Cdd:COG0686  170 KVVILGGGVVG----TNAARMAlglgADVTVLDINLDRLRRLDDIFGgrVTTL---YSNPANIEEA-LKEADLVIgAV 239
L-AlaDH cd05305
Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) ...
 2-72 1.36e-05

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.


Pssm-ID: 240630 [Multi-domain]  Cd Length: 359  Bit Score: 47.01  E-value: 1.36e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518451005   2 KIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDRLDIRtVEGKASHPTILDQAgARDADMLI-AV 72
Cdd:cd05305  170 KVVILGAGVVGENAARVALGLGAEVTVLDINLERLRYLDDIFGGR-VTTLYSNPANLEEA-LKEADLVIgAV 239
NAD_bind_Leu_Phe_Val_DH cd01075
NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine ...
 1-85 2.68e-04

NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. For example, leucine DH catalyzes the reversible oxidative deamination of L-leucine and several other straight or branched chain amino acids to the corresponding 2-oxoacid derivative. Amino acid DH -like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133444  Cd Length: 200  Bit Score: 41.81  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005   1 MKIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDRLDIRTVEGKAshptILDQagarDADMLI-----AVTNS 75
Cdd:cd01075   29 KTVAVQGLGKVGYKLAEHLLEEGAKLIVADINEEAVARAAELFGATVVAPEE----IYSV----DADVFApcalgGVIND 100

                         90
                 ....*....|
gi 518451005  76 DEVNMVACQI 85
Cdd:cd01075  101 DTIPQLKAKA 110
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 360-451 3.24e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 43.19  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 360 THVRRGDVAAVhslrRGAAEALEAVAH--G-------------DSR-----SSKVVGKMIEEIDLPK--GTTIGAIVRND 417
Cdd:COG2985  248 TVLQEGDIVLV----VGTREALEAAEAllGeevddselldsdlDVRrivvtNKEVAGKTLGELNLRNrfGVVITRVRRGG 323

                         90       100       110
                 ....*....|....*....|....*....|....
gi 518451005 418 EVLIAHDDVVVENDDhVILFLVDKRKIGEVERLF 451
Cdd:COG2985  324 VELPATPDTVLQLGD-RLTVVGPKEDVERVAKLL 356
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-72 4.02e-04

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 41.97  E-value: 4.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518451005   1 MKIIILGAGQVGGTLAENLAS---EANDITIVDTDMGRLRELQDRLDIRTVEGkashptilDQAGARDADMLI-AV 72
Cdd:COG0345    3 MKIGFIGAGNMGSAIIKGLLKsgvPPEDIIVSDRSPERLEALAERYGVRVTTD--------NAEAAAQADVVVlAV 70
Mdh COG0039
Malate/lactate dehydrogenase [Energy production and conversion]; Malate/lactate dehydrogenase ...
 1-41 1.24e-03

Malate/lactate dehydrogenase [Energy production and conversion]; Malate/lactate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439809 [Multi-domain]  Cd Length: 302  Bit Score: 40.77  E-value: 1.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 518451005   1 MKIIILGAGQVGGTLAENLASE--ANDITIVDTDMGRLR----ELQD 41
Cdd:COG0039    1 MKVAIIGAGNVGSTLAFRLASGglADELVLIDINEGKAEgealDLAD 47
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 1-70 2.99e-03

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 39.45  E-value: 2.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518451005   1 MKIIILGAGQVGGTLAENLASEANDITIVDTDMGRLRELQDR-LDIRTVEGKASHPTILDQAGARDADMLI 70
Cdd:PRK06522   1 MKIAILGAGAIGGLFGAALAQAGHDVTLVARRGAHLDALNENgLRLEDGEITVPVLAADDPAELGPQDLVI 71
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 320-451 3.22e-03

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 37.98  E-value: 3.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005 320 RLGARTVMTLINNPAYVDLVQGGVIDIAISPQQTTIGSLLTHVRRGDVAAVHSLRRGAAEALEAVAHGDSRS------SK 393
Cdd:COG0490    1 AALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLLAIEEvkvppgSP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518451005 394 VVGKMIEEIDLPK--GTTIGAIVRNDEVLIAHD-DVVVENDDhVILFLVDKRKIGEVERLF 451
Cdd:COG0490   81 LVGKTLGELNLRQrtGVTVVAIRRGGEVILSPGpDTVLEAGD-TLVVVGTREQLERLEELL 140
WcaG COG0451
Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];
2-70 3.24e-03

Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440220 [Multi-domain]  Cd Length: 295  Bit Score: 39.19  E-value: 3.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518451005   2 KIIILGA-GQVGGTLAENLASEANDITIVDTDMGRLRELQDRLDIRTVEGKASHPTILDQAgARDADMLI 70
Cdd:COG0451    1 RILVTGGaGFIGSHLARRLLARGHEVVGLDRSPPGAANLAALPGVEFVRGDLRDPEALAAA-LAGVDAVV 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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