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Conserved domains on  [gi|518465639|ref|WP_019635846|]
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glucose-6-phosphate dehydrogenase [Paenibacillus fonticola]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11417513)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 11-501 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 839.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  11 KTPGAVYFIFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYSVeDNADWSRFAE 90
Cdd:COG0364    6 PAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPF-DEEVWERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  91 HFSYKSLDINNIDGYRELLQQTEEVEARYdIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSA 170
Cdd:COG0364   85 RLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 171 QKLNEELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMG 250
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 251 QNHMLQLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYsSPQEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTET 330
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPI-TPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTET 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 331 YFAAKVFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTES 410
Cdd:COG0364  323 FVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGM 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 411 QINPLAMEFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQ 490
Cdd:COG0364  403 RLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482

                        490
                 ....*....|.
gi 518465639 491 LLAQDGFHWWP 501
Cdd:COG0364  483 LLARDGRSWRE 493
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 11-501 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 839.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  11 KTPGAVYFIFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYSVeDNADWSRFAE 90
Cdd:COG0364    6 PAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPF-DEEVWERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  91 HFSYKSLDINNIDGYRELLQQTEEVEARYdIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSA 170
Cdd:COG0364   85 RLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 171 QKLNEELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMG 250
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 251 QNHMLQLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYsSPQEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTET 330
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPI-TPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTET 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 331 YFAAKVFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTES 410
Cdd:COG0364  323 FVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGM 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 411 QINPLAMEFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQ 490
Cdd:COG0364  403 RLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482

                        490
                 ....*....|.
gi 518465639 491 LLAQDGFHWWP 501
Cdd:COG0364  483 LLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 19-500 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 807.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRySVEDNADWSRFAEHFSYKSLD 98
Cdd:PRK05722  14 IFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFAR-TPFDEEVWERFLSRLYYVSGD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  99 INNIDGYRELLQQTEEVEARYDIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSAQKLNEELN 178
Cdd:PRK05722  93 VTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASARELNDQVG 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 179 QVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHMLQLL 258
Cdd:PRK05722 173 EVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQLL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 259 TMIAMEPPSRLLAEDIRDEKVKVLRSLRPYsSPQEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAKVFV 338
Cdd:PRK05722 253 ALVAMEPPASLDADSIRDEKVKVLRALRPI-TPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALKLEI 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 339 DNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQINPLAME 418
Cdd:PRK05722 332 DNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPVKLD 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 419 FCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQLLAQDGFH 498
Cdd:PRK05722 412 FSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLARDGRS 491


                 ..
gi 518465639 499 WW 500
Cdd:PRK05722 492 WR 493
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 19-501 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 688.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639   19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYSVEDnaDWSRFAEHFSYKSLD 98
Cdd:TIGR00871   7 IFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDE--QWDEFAQRLSYVSGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639   99 INNIDGYRELLQQTEEVEARYDIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSAQKLNEELN 178
Cdd:TIGR00871  85 VDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELNKALR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  179 QVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHMLQLL 258
Cdd:TIGR00871 165 AVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  259 TMIAMEPPSRLLAEDIRDEKVKVLRSLRPYSspqEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAKVFV 338
Cdd:TIGR00871 245 ALVAMEPPVSFDADSIRDEKVKVLKALRPID---PDDNNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALKLEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  339 DNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKLEP-NLLVIRVNPMEGIYIKINAKKPGTESQINPLAM 417
Cdd:TIGR00871 322 DNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKL 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  418 EFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESG-DISTYAAGSWGPEEADQLLAQDG 496
Cdd:TIGR00871 402 DFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGpSPPNYPAGSWGPKEADELIRKDG 481


                  ....*
gi 518465639  497 FHWWP 501
Cdd:TIGR00871 482 RSWRK 486
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
203-500 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 522.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  203 VIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHMLQLLTMIAMEPPSRLLAEDIRDEKVKVL 282
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  283 RSLRPYsSPQEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAKVFVDNFRWAGVPFYIRTGKRLPVKTTE 362
Cdd:pfam02781  82 RSLRPI-TPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  363 VVVEFKQMPTNVYlGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQINPLAMEFCQSCQVGINSPEAYERLIHDAAN 442
Cdd:pfam02781 161 IRIQFKDVPHNLF-RDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 518465639  443 GDSTYFTRWDEVATAWAFVDRIASAWtqESGDISTYAAGSWGPEEADQLLAQDGFHWW 500
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAW--DEEKPPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 11-501 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 839.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  11 KTPGAVYFIFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYSVeDNADWSRFAE 90
Cdd:COG0364    6 PAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKPF-DEEVWERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  91 HFSYKSLDINNIDGYRELLQQTEEVEARYdIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSA 170
Cdd:COG0364   85 RLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 171 QKLNEELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMG 250
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 251 QNHMLQLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYsSPQEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTET 330
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPI-TPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTET 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 331 YFAAKVFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTES 410
Cdd:COG0364  323 FVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGM 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 411 QINPLAMEFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQ 490
Cdd:COG0364  403 RLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482

                        490
                 ....*....|.
gi 518465639 491 LLAQDGFHWWP 501
Cdd:COG0364  483 LLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 19-500 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 807.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRySVEDNADWSRFAEHFSYKSLD 98
Cdd:PRK05722  14 IFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFAR-TPFDEEVWERFLSRLYYVSGD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  99 INNIDGYRELLQQTEEVEARYDIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSAQKLNEELN 178
Cdd:PRK05722  93 VTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASARELNDQVG 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 179 QVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHMLQLL 258
Cdd:PRK05722 173 EVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQLL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 259 TMIAMEPPSRLLAEDIRDEKVKVLRSLRPYsSPQEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAKVFV 338
Cdd:PRK05722 253 ALVAMEPPASLDADSIRDEKVKVLRALRPI-TPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALKLEI 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 339 DNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQINPLAME 418
Cdd:PRK05722 332 DNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPVKLD 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 419 FCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQLLAQDGFH 498
Cdd:PRK05722 412 FSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLARDGRS 491


                 ..
gi 518465639 499 WW 500
Cdd:PRK05722 492 WR 493
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 19-501 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 688.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639   19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYSVEDnaDWSRFAEHFSYKSLD 98
Cdd:TIGR00871   7 IFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEIDE--QWDEFAQRLSYVSGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639   99 INNIDGYRELLQQTEEVEARYDIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSAQKLNEELN 178
Cdd:TIGR00871  85 VDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELNKALR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  179 QVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHMLQLL 258
Cdd:TIGR00871 165 AVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  259 TMIAMEPPSRLLAEDIRDEKVKVLRSLRPYSspqEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAKVFV 338
Cdd:TIGR00871 245 ALVAMEPPVSFDADSIRDEKVKVLKALRPID---PDDNNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALKLEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  339 DNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKLEP-NLLVIRVNPMEGIYIKINAKKPGTESQINPLAM 417
Cdd:TIGR00871 322 DNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKL 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  418 EFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESG-DISTYAAGSWGPEEADQLLAQDG 496
Cdd:TIGR00871 402 DFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGpSPPNYPAGSWGPKEADELIRKDG 481


                  ....*
gi 518465639  497 FHWWP 501
Cdd:TIGR00871 482 RSWRK 486
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
18-501 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 642.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  18 FIFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYSVEDNAdWSRFAEHFSYKSL 97
Cdd:PRK12853  12 VIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGADGFDDAV-WDRLAARLSYVQG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  98 DINNIDGYRELLQQTEEvearydiPGNRLFYLALAPELFGSVSFNLQKGGMLDssGWHRLVIEKPFGYDLLSAQKLNEEL 177
Cdd:PRK12853  91 DVTDPADYARLAEALGP-------GGNPVFYLAVPPSLFAPVVENLGAAGLLP--EGRRVVLEKPFGHDLASARALNATL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 178 NQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHMLQL 257
Cdd:PRK12853 162 AKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLLQL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 258 LTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYsSPQEVkeNVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAKVF 337
Cdd:PRK12853 242 LALVAMEPPASFDADAVRDEKAKVLRAIRPL-DPDDV--HTVRGQYTAGTVGGEPVPGYREEPGVDPDSRTETFVALKLE 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 338 VDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPtNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQINPLAM 417
Cdd:PRK12853 319 IDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVP-HALFRGTGVEPPNRLVIRLQPDEGISLELNVKRPGPGMRLRPVEL 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 418 EFCQscQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQLLAQDGF 497
Cdd:PRK12853 398 DADY--ADDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLARDGR 475


                 ....
gi 518465639 498 HWWP 501
Cdd:PRK12853 476 GWRE 479
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
203-500 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 522.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  203 VIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHMLQLLTMIAMEPPSRLLAEDIRDEKVKVL 282
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  283 RSLRPYsSPQEVKENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAKVFVDNFRWAGVPFYIRTGKRLPVKTTE 362
Cdd:pfam02781  82 RSLRPI-TPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  363 VVVEFKQMPTNVYlGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQINPLAMEFCQSCQVGINSPEAYERLIHDAAN 442
Cdd:pfam02781 161 IRIQFKDVPHNLF-RDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 518465639  443 GDSTYFTRWDEVATAWAFVDRIASAWtqESGDISTYAAGSWGPEEADQLLAQDGFHWW 500
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAW--DEEKPPPYPAGSWGPKAADELLARDGRKWR 295
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 19-505 5.61e-164

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 475.78  E-value: 5.61e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRtreefrDDVYRSIQEF-CRYSV---EDNADWSRFAEHFSY 94
Cdd:PTZ00309  59 VLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKM------SDVERWKKETlARFFKrldDRECHLEQFLKHISY 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  95 KSLDINNIDGYRELLQQTEEVEARYDIP---GNRLFYLALAPELFGSVSFNLQKGGMlDSSGWHRLVIEKPFGYDLLSAQ 171
Cdd:PTZ00309 133 ISGSYDEDEDFKRLNKLIERMEEAFQGPekgGNRLFYLALPPSVFASVCEGIHRGCM-SKNGWVRVIVEKPFGRDLESSE 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 172 KLNEELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQ 251
Cdd:PTZ00309 212 ELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQ 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 252 NHMLQLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYSspqevKENVVRGQYAAGESGgkALPGYRQEDKVDPNSNTETY 331
Cdd:PTZ00309 292 NHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIK-----MEECVLGQYTASADG--SIPGYLEDEGVPKDSTTPTF 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 332 FAAKVFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQkhKLEPNLLVIRVNPMEGIYIKINAKKPGTESQ 411
Cdd:PTZ00309 365 AAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGD--DTQRNELVIRAQPSEAMYLKITAKVPGLSND 442

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 412 INPLAMEFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQL 491
Cdd:PTZ00309 443 LHQTELDLTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADEL 522

                        490       500
                 ....*....|....*....|
gi 518465639 492 LAQDGF------HWWPVNGQ 505
Cdd:PTZ00309 523 IKKNGFksskgyQWLQSNDQ 542
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 16-508 1.16e-161

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 467.59  E-value: 1.16e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  16 VYFIFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYSVEDnADWSRFAEHFSYK 95
Cdd:PRK12854  13 VFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEFGARKLDD-GEWARFAKRLRYV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  96 SLDINNiDGYRELLQQTEEVEARYDIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSgwhRLVIEKPFGYDLLSAQKLNE 175
Cdd:PRK12854  92 PGGFLS-AGPGALAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEAGLAEGS---RVVMEKPFGTDLASAEALNA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 176 ELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHML 255
Cdd:PRK12854 168 AVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHLF 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 256 QLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYSSpqevkENVVRGQYAagesggkalpGYRQEDKVDPNSNTETYFAAK 335
Cdd:PRK12854 248 QVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDP-----AEVVRGQYS----------GYRDEPGVAPDSTTETFVALK 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 336 VFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVY-LGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQINP 414
Cdd:PRK12854 313 VWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFpAGSVGAQGPDHLTFDLADNSKVSLSFYGKRPGPGMRLDK 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 415 LAMEF-CQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIasawTQESGDISTYAAGSWGPEEADQLLA 493
Cdd:PRK12854 393 LSLQFsLKDTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPL----LEDPPPVKPYAPGSWGPNAIHQLAA 468

                        490
                 ....*....|....*
gi 518465639 494 QDGfhwWPVNGQEED 508
Cdd:PRK12854 469 PDA---WRLPFEREW 480
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 19-497 5.58e-134

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 397.17  E-value: 5.58e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  19 IFGATGDLARRKLFPAIYSLYREGKLGED-FAVIGVARRPRTREEFRDdvyrSIQEFCRYSVEDNAD-WSRFAEHFSYKS 96
Cdd:PLN02539  22 VLGASGDLAKKKTFPALFNLYRQGFLPPDeVHIFGYARSKITDEELRD----RIRGYLKDEKNAPAEaVSKFLQLIKYVS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  97 LDINNIDGYRELLQQTEEVEAR---YDIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSAQKL 173
Cdd:PLN02539  98 GAYDSEEGFRRLDKEISEHEISknsAEGSSRRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKDLESAEEL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 174 NEELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNH 253
Cdd:PLN02539 178 SSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNH 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 254 MLQLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYSSpqevkENVVRGQYaagesggkalPGYRQEDKVDPNSNTETYFA 333
Cdd:PLN02539 258 LLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKD-----EEVVLGQY----------EGYRDDPTVPDDSNTPTFAS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 334 AKVFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVYLGQKHKlePNLLVIRVNPMEGIYIKINAKKPGTESQI- 412
Cdd:PLN02539 323 VVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKCQKQG--RNEFVIRLQPSEAMYMKLTVKQPGLEMSTv 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 413 -NPLAMEFCQSCQvGINSPEAYERLIHDAANGDSTYFTRWDEVATAWA----FVDRIasawtqESGDIST--YAAGSWGP 485
Cdd:PLN02539 401 qSELDLSYGQRYQ-DVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEiftpLLHRI------DAGKVKPipYKQGSRGP 473

                        490
                 ....*....|..
gi 518465639 486 EEADQLLAQDGF 497
Cdd:PLN02539 474 AEADELLEKAGY 485
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 19-499 3.95e-130

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 390.14  E-value: 3.95e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQefCRYSVEDNAD--WSRFAEHFSYKS 96
Cdd:PLN02640  93 VVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLT--CRIDQRENCGdkMDQFLKRCFYHS 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  97 LDINNIDGYRELLQQTEEVEARyDIPgNRLFYLALAPELFGSVsfnLQKGGMLDSS--GWHRLVIEKPFGYDLLSAQKLN 174
Cdd:PLN02640 171 GQYDSEEDFAELNKKLKEKEAG-KLS-NRLFYLSIPPNIFVDV---VRCASLRASSenGWTRVIVEKPFGRDSESSGELT 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 175 EELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHM 254
Cdd:PLN02640 246 RCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHL 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 255 LQLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYSSpqevkENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAA 334
Cdd:PLN02640 326 LQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQL-----EDVIVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFAAA 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 335 KVFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVY---LGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQ 411
Cdd:PLN02640 401 ALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYkrnFGTDLDKATNELVLRVQPDEAIYLKINNKVPGLGMR 480

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 412 INPLAMEFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQL 491
Cdd:PLN02640 481 LDRSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSRGPVGAHYL 560


                 ....*...
gi 518465639 492 LAQDGFHW 499
Cdd:PLN02640 561 AAKYNVRW 568
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 19-499 4.95e-129

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 388.57  E-value: 4.95e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQefCRYSVEDNAD--WSRFAEHFSYKS 96
Cdd:PLN02333 122 VVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLT--CRIDKRENCGekMEEFLKRCFYHS 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639  97 LDINNIDGYRELLQQTEEVEA-RYDipgNRLFYLALAPELFGSvSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSAQKLNE 175
Cdd:PLN02333 200 GQYDSQEHFAELDKKLKEHEGgRVS---NRLFYLSIPPNIFVD-AVKCASSSASSVNGWTRVIVEKPFGRDSESSAALTK 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 176 ELNQVFKEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDNAGALRDMGQNHML 255
Cdd:PLN02333 276 SLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLL 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 256 QLLTMIAMEPPSRLLAEDIRDEKVKVLRSLRPYSSpqevkENVVRGQYAAGESGGKALPGYRQEDKVDPNSNTETYFAAK 335
Cdd:PLN02333 356 QILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQL-----EDVVIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAAAA 430

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 336 VFVDNFRWAGVPFYIRTGKRLPVKTTEVVVEFKQMPTNVY---LGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGTESQI 412
Cdd:PLN02333 431 LFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYnrnFGTDLDQATNELVIRVQPDEAIYLKINNKVPGLGMRL 510

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639 413 NPLAMEFCQSCQVGINSPEAYERLIHDAANGDSTYFTRWDEVATAWAFVDRIASAWTQESGDISTYAAGSWGPEEADQLL 492
Cdd:PLN02333 511 DRSNLNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPEYYPYGSRGPVGAHYLA 590


                 ....*..
gi 518465639 493 AQDGFHW 499
Cdd:PLN02333 591 ARYKVRW 597
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
19-200 1.22e-93

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 282.39  E-value: 1.22e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639   19 IFGATGDLARRKLFPAIYSLYREGKLGEDFAVIGVARRPRTREEFRDDVYRSIQEFCRYsveDNADWSRFAEHFSYKSLD 98
Cdd:pfam00479   2 IFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFKEL---DEEKWDRFLERLHYVSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518465639   99 INNIDGYRELLQQTEEVEARydIPGNRLFYLALAPELFGSVSFNLQKGGMLDSSGWHRLVIEKPFGYDLLSAQKLNEELN 178
Cdd:pfam00479  79 FDDPESYEKLKERLEEHEDE--TRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARELNDQLA 156

                         170       180
                  ....*....|....*....|..
gi 518465639  179 QVFKEEEIYRIDHYLGKEMVQN 200
Cdd:pfam00479 157 KVFKEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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