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Conserved domains on  [gi|518484672|ref|WP_019654879|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Variovorax]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-139 1.48e-20

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 81.55  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672  13 FKVRQLSRRLSQHYDAEVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIA-QSAGADARS 91
Cdd:COG1846   14 LLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVErEPDPEDRRA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 518484672  92 RLVQLTEEGEAKRREALAHWKTAQQKLNALLGVERVLALHLLIDEAME 139
Cdd:COG1846   94 VLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-139 1.48e-20

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 81.55  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672  13 FKVRQLSRRLSQHYDAEVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIA-QSAGADARS 91
Cdd:COG1846   14 LLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVErEPDPEDRRA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 518484672  92 RLVQLTEEGEAKRREALAHWKTAQQKLNALLGVERVLALHLLIDEAME 139
Cdd:COG1846   94 VLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-109 2.24e-08

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 48.74  E-value: 2.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672    28 AEVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQSAGA-DARSRLVQLTEEGEAKRRE 106
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPeDRRSVLVSLTEEGRELIEQ 80


                   ...
gi 518484672   107 ALA 109
Cdd:smart00347  81 LLE 83
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-91 4.07e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 47.20  E-value: 4.07e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672   33 SGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIA-QSAGADARS 91
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVErEPSPADRRA 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
7-134 8.97e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 42.96  E-value: 8.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672   7 PRGCTSFKVRQLSRRLSQHYdaeVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQSAG 86
Cdd:PRK11512  13 PLGRLIHMVNQKKDRLLNEY---LSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPN 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 518484672  87 -ADARSRLVQLTEEGEAKRREalAHWKTAQ---QKLNALLGVERVLALHLLI 134
Cdd:PRK11512  90 pNDKRGVLVKLTTSGAAICEQ--CHQLVGQdlhQELTKNLTADEVATLEHLL 139
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-139 1.48e-20

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 81.55  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672  13 FKVRQLSRRLSQHYDAEVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIA-QSAGADARS 91
Cdd:COG1846   14 LLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVErEPDPEDRRA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 518484672  92 RLVQLTEEGEAKRREALAHWKTAQQKLNALLGVERVLALHLLIDEAME 139
Cdd:COG1846   94 VLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-109 2.24e-08

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 48.74  E-value: 2.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672    28 AEVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQSAGA-DARSRLVQLTEEGEAKRRE 106
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPeDRRSVLVSLTEEGRELIEQ 80


                   ...
gi 518484672   107 ALA 109
Cdd:smart00347  81 LLE 83
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-91 4.07e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 47.20  E-value: 4.07e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672   33 SGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIA-QSAGADARS 91
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVErEPSPADRRA 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
7-134 8.97e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 42.96  E-value: 8.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518484672   7 PRGCTSFKVRQLSRRLSQHYdaeVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQSAG 86
Cdd:PRK11512  13 PLGRLIHMVNQKKDRLLNEY---LSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPN 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 518484672  87 -ADARSRLVQLTEEGEAKRREalAHWKTAQ---QKLNALLGVERVLALHLLI 134
Cdd:PRK11512  90 pNDKRGVLVKLTTSGAAICEQ--CHQLVGQdlhQELTKNLTADEVATLEHLL 139
HTH_27 pfam13463
Winged helix DNA-binding domain;
35-100 2.47e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 37.27  E-value: 2.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518484672   35 LKTTQYSLLSHL-ARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQSAGA-DARSRLVQLTEEG 100
Cdd:pfam13463   1 LTRLEALILHNIgHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEeDGRETRVRLTAKG 68
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
42-102 4.77e-04

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 38.07  E-value: 4.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518484672  42 LLSHLAR-LGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQsagadARSRLVQLTEEGEA 102
Cdd:PRK11050  41 LIADLIAeVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEM-----RPYRGVFLTPEGEK 97
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
38-79 8.46e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.55  E-value: 8.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 518484672  38 TQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAG 79
Cdd:COG3398   98 TPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDG 139
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
50-103 2.62e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.95  E-value: 2.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 518484672  50 GPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQSagadaRSRLVQLTEEGEAK 103
Cdd:COG1321   23 GPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYE-----PYGGITLTEEGREL 71
PRK11716 PRK11716
HTH-type transcriptional activator IlvY;
63-119 3.53e-03

HTH-type transcriptional activator IlvY;


Pssm-ID: 236961 [Multi-domain]  Cd Length: 269  Bit Score: 36.33  E-value: 3.53e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518484672  63 MTASTLSRNLQPLiaagwiAQSAGA-----DARSrlVQLTEEGEAKR---REALAHWKTAQQKLN 119
Cdd:PRK11716   3 VSPSTLSRQIQRL------EEELGQplfvrDNRS--VTLTEAGEELRpfaQQTLLQWQQLRHTLD 59
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
27-102 3.61e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.05  E-value: 3.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518484672  27 DAEVSQSGLKTTQYSLLSHLARLGPSRPVDLAAELKMTASTLSRNLQPLIAAGWIAQSAGADAR---SRLVQLTEEGEA 102
Cdd:COG2345    3 DTPALAALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRGRgrpAKLYRLTEAGRA 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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