NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|518491762|ref|WP_019661969|]
View 

MULTISPECIES: BlaI/MecI/CopY family transcriptional regulator [Stenotrophomonas]

Protein Classification

BlaI/MecI/CopY family transcriptional regulator( domain architecture ID 10007832)

BlaI/MecI/CopY family transcriptional regulator similar to Mycobacterium tuberculosis transcriptional regulator BlaI and Staphylococcus aureus repressor and methicillin resistance regulatory protein MecI

CATH:  1.10.10.10
Gene Ontology:  GO:0045892|GO:0003677
PubMed:  8226686
SCOP:  4000185

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-125 2.09e-35

Transcriptional regulator, CopY/TcrY family [Transcription];


:

Pssm-ID: 442898  Cd Length: 125  Bit Score: 117.97  E-value: 2.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518491762   4 KTIGDQELALLQYIDEHAPASVGEVASGYGEARGLARSTVLTMMERLRAKGYLQRRQQDGVYRYQATRGPQSVLQGAVAQ 83
Cdd:COG3682    3 KKLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQELRD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 518491762  84 FVDNTLQGSVSPFVAYLSQRQQVSDNELAELEALVAQLQSRR 125
Cdd:COG3682   83 LLDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKKKKK 124
 
Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-125 2.09e-35

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 117.97  E-value: 2.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518491762   4 KTIGDQELALLQYIDEHAPASVGEVASGYGEARGLARSTVLTMMERLRAKGYLQRRQQDGVYRYQATRGPQSVLQGAVAQ 83
Cdd:COG3682    3 KKLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQELRD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 518491762  84 FVDNTLQGSVSPFVAYLSQRQQVSDNELAELEALVAQLQSRR 125
Cdd:COG3682   83 LLDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKKKKK 124
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 6-120 4.10e-30

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 104.22  E-value: 4.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518491762    6 IGDQELALLQYIDEHAPASVGEVASGYGEARGLARSTVLTMMERLRAKGYLQRRQQDGVYRYQATRGPQSVLQGAVAQFV 85
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKDGRAFIYSPLVSREEYKAGQVKQLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 518491762   86 DNTLQGSVSPFVAYLSQRQQVSDNELAELEALVAQ 120
Cdd:pfam03965  81 DRFFGGSVPALVANFVEREKLSPDDIEELRQLLDQ 115
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
11-66 2.65e-03

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 34.87  E-value: 2.65e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 518491762    11 LALLQYIDEHAP-ASVGEVAsgygEARGLARSTVLTMMERLRAKGYLQRRQQDGVYR 66
Cdd:smart00346   8 LAVLRALAEEPGgLTLAELA----ERLGLSKSTAHRLLNTLQELGYVEQDGQNGRYR 60
 
Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-125 2.09e-35

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 117.97  E-value: 2.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518491762   4 KTIGDQELALLQYIDEHAPASVGEVASGYGEARGLARSTVLTMMERLRAKGYLQRRQQDGVYRYQATRGPQSVLQGAVAQ 83
Cdd:COG3682    3 KKLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQELRD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 518491762  84 FVDNTLQGSVSPFVAYLSQRQQVSDNELAELEALVAQLQSRR 125
Cdd:COG3682   83 LLDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKKKKK 124
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 6-120 4.10e-30

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 104.22  E-value: 4.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518491762    6 IGDQELALLQYIDEHAPASVGEVASGYGEARGLARSTVLTMMERLRAKGYLQRRQQDGVYRYQATRGPQSVLQGAVAQFV 85
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKDGRAFIYSPLVSREEYKAGQVKQLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 518491762   86 DNTLQGSVSPFVAYLSQRQQVSDNELAELEALVAQ 120
Cdd:pfam03965  81 DRFFGGSVPALVANFVEREKLSPDDIEELRQLLDQ 115
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
12-65 1.63e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 38.65  E-value: 1.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 518491762  12 ALLQYIDEHAPASVGEVAsgygEARGLARSTVLTMMERLRAKGYLQRRQQDGVY 65
Cdd:COG1321   14 AIYELSEEGGPVRTSDIA----ERLGVSPPSVTEMLKKLEEKGLVEYEPYGGIT 63
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
11-66 3.18e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 38.65  E-value: 3.18e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 518491762  11 LALLQYIDEHA-PASVGEVAsgygEARGLARSTVLTMMERLRAKGYLQRRQQDGVYR 66
Cdd:COG1414   12 LAILEALAEAGgGLSLSELA----RRLGLPKSTVHRLLATLEEEGYVERDPEGGRYR 64
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
8-56 9.30e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 34.72  E-value: 9.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 518491762    8 DQELALLQYIDEHAPASVGEVAsgygEARGLARSTVLTMMERLRAKGYL 56
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELA----ERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
11-66 2.65e-03

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 34.87  E-value: 2.65e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 518491762    11 LALLQYIDEHAP-ASVGEVAsgygEARGLARSTVLTMMERLRAKGYLQRRQQDGVYR 66
Cdd:smart00346   8 LAVLRALAEEPGgLTLAELA----ERLGLSKSTAHRLLNTLQELGYVEQDGQNGRYR 60
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-59 7.30e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.18  E-value: 7.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 518491762  10 ELALLQYIDEHAPASVGEVAsgygEARGLARSTVLTMMERLRAKGYLQRR 59
Cdd:COG1846   40 QFRVLAALAEAGGLTQSELA----ERLGLTKSTVSRLLDRLEEKGLVERE 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH