NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|518518370|ref|WP_019688577|]
View 

MULTISPECIES: glucose-6-phosphate dehydrogenase [Paenibacillus]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11417513)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 11-501 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 831.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  11 VTQGAVLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRyKAENDQEWQAFAE 90
Cdd:COG0364    6 PAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSR-KPFDEEVWERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  91 HFEYKSLDINNVDGFHELRQQTEAIEGKFnIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESA 170
Cdd:COG0364   85 RLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 171 QELNIEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMG 250
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 251 QNHMLQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDVKTNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTET 330
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPI-TPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTET 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 331 YFASRVFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSES 410
Cdd:COG0364  323 FVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGM 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 411 DIEPLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGPDGAHK 490
Cdd:COG0364  403 RLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482

                        490
                 ....*....|.
gi 518518370 491 LLEQDGYKWWP 501
Cdd:COG0364  483 LLARDGRSWRE 493
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 11-501 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 831.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  11 VTQGAVLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRyKAENDQEWQAFAE 90
Cdd:COG0364    6 PAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSR-KPFDEEVWERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  91 HFEYKSLDINNVDGFHELRQQTEAIEGKFnIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESA 170
Cdd:COG0364   85 RLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 171 QELNIEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMG 250
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 251 QNHMLQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDVKTNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTET 330
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPI-TPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTET 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 331 YFASRVFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSES 410
Cdd:COG0364  323 FVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGM 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 411 DIEPLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGPDGAHK 490
Cdd:COG0364  403 RLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482

                        490
                 ....*....|.
gi 518518370 491 LLEQDGYKWWP 501
Cdd:COG0364  483 LLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 16-500 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 802.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  16 VLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRyKAENDQEWQAFAEHFEYK 95
Cdd:PRK05722  11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFAR-TPFDEEVWERFLSRLYYV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  96 SLDINNVDGFHELRQQTEAIEGKFNIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESAQELNI 175
Cdd:PRK05722  90 SGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASARELND 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 176 EIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHML 255
Cdd:PRK05722 170 QVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 256 QMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDVKTNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFASR 335
Cdd:PRK05722 250 QLLALVAMEPPASLDADSIRDEKVKVLRALRPI-TPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALK 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 336 VFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSESDIEPL 415
Cdd:PRK05722 329 LEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPV 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 416 AMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGPDGAHKLLEQD 495
Cdd:PRK05722 409 KLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLARD 488


                 ....*
gi 518518370 496 GYKWW 500
Cdd:PRK05722 489 GRSWR 493
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 15-501 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 674.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   15 AVLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSryKAENDQEWQAFAEHFEY 94
Cdd:TIGR00871   3 CILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFE--TDEIDEQWDEFAQRLSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   95 KSLDINNVDGFHELRQQTEAIEGKFNIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESAQELN 174
Cdd:TIGR00871  81 VSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  175 IEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHM 254
Cdd:TIGR00871 161 KALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  255 LQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFGSSEDvktNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFAS 334
Cdd:TIGR00871 241 LQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDN---NTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  335 RVFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKLEP-NLLVIRVNPMEGIYIKINAKKPGSESDIE 413
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  414 PLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPD-TLETYAAGSWGPDGAHKLL 492
Cdd:TIGR00871 398 PVKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGpSPPNYPAGSWGPKEADELI 477


                  ....*....
gi 518518370  493 EQDGYKWWP 501
Cdd:TIGR00871 478 RKDGRSWRK 486
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
203-500 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 515.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  203 VIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHMLQMLTMIAMEPPSRLLPEDIRDEKVKVL 282
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  283 RSLRPFgSSEDVKTNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFASRVFVDNFRWAGVPFYIRTGKRLPVKTTE 362
Cdd:pfam02781  82 RSLRPI-TPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  363 IVVEFKSMPTNVYlGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSESDIEPLAMDFCQSCMVGINSPEAYERLLMDAIE 442
Cdd:pfam02781 161 IRIQFKDVPHNLF-RDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 518518370  443 GDSTYFTRWDEVATAWGFVDRIAKAWQQTPdtLETYAAGSWGPDGAHKLLEQDGYKWW 500
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 11-501 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 831.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  11 VTQGAVLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRyKAENDQEWQAFAE 90
Cdd:COG0364    6 PAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSR-KPFDEEVWERFLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  91 HFEYKSLDINNVDGFHELRQQTEAIEGKFnIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESA 170
Cdd:COG0364   85 RLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLASA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 171 QELNIEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMG 250
Cdd:COG0364  164 RELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 251 QNHMLQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDVKTNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTET 330
Cdd:COG0364  244 QNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPI-TPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTET 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 331 YFASRVFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSES 410
Cdd:COG0364  323 FVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGM 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 411 DIEPLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGPDGAHK 490
Cdd:COG0364  403 RLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADA 482

                        490
                 ....*....|.
gi 518518370 491 LLEQDGYKWWP 501
Cdd:COG0364  483 LLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 16-500 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 802.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  16 VLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRyKAENDQEWQAFAEHFEYK 95
Cdd:PRK05722  11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFAR-TPFDEEVWERFLSRLYYV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  96 SLDINNVDGFHELRQQTEAIEGKFNIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESAQELNI 175
Cdd:PRK05722  90 SGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASARELND 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 176 EIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHML 255
Cdd:PRK05722 170 QVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 256 QMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDVKTNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFASR 335
Cdd:PRK05722 250 QLLALVAMEPPASLDADSIRDEKVKVLRALRPI-TPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALK 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 336 VFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSESDIEPL 415
Cdd:PRK05722 329 LEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPV 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 416 AMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGPDGAHKLLEQD 495
Cdd:PRK05722 409 KLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLARD 488


                 ....*
gi 518518370 496 GYKWW 500
Cdd:PRK05722 489 GRSWR 493
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 15-501 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 674.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   15 AVLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSryKAENDQEWQAFAEHFEY 94
Cdd:TIGR00871   3 CILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFE--TDEIDEQWDEFAQRLSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   95 KSLDINNVDGFHELRQQTEAIEGKFNIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESAQELN 174
Cdd:TIGR00871  81 VSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  175 IEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHM 254
Cdd:TIGR00871 161 KALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  255 LQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFGSSEDvktNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFAS 334
Cdd:TIGR00871 241 LQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDN---NTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  335 RVFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKLEP-NLLVIRVNPMEGIYIKINAKKPGSESDIE 413
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  414 PLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPD-TLETYAAGSWGPDGAHKLL 492
Cdd:TIGR00871 398 PVKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGpSPPNYPAGSWGPKEADELI 477


                  ....*....
gi 518518370  493 EQDGYKWWP 501
Cdd:TIGR00871 478 RKDGRSWRK 486
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
17-501 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 631.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  17 LFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRYKAEnDQEWQAFAEHFEYKS 96
Cdd:PRK12853  11 LVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGADGFD-DAVWDRLAARLSYVQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  97 LDINNVDGFHELRQqteaiegKFNIPGNRLFYLALAPELFGSVSKSLKEGGMLDGkgWNRLVIEKPFGYNLESAQELNIE 176
Cdd:PRK12853  90 GDVTDPADYARLAE-------ALGPGGNPVFYLAVPPSLFAPVVENLGAAGLLPE--GRRVVLEKPFGHDLASARALNAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 177 IREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHMLQ 256
Cdd:PRK12853 161 LAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLLQ 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 257 MLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDVKTnvVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFASRV 336
Cdd:PRK12853 241 LLALVAMEPPASFDADAVRDEKAKVLRAIRPL-DPDDVHT--VRGQYTAGTVGGEPVPGYREEPGVDPDSRTETFVALKL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 337 FVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPtNVYLGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSESDIEPLA 416
Cdd:PRK12853 318 EIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVP-HALFRGTGVEPPNRLVIRLQPDEGISLELNVKRPGPGMRLRPVE 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 417 MDFCQScmVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGPDGAHKLLEQDG 496
Cdd:PRK12853 397 LDADYA--DDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLARDG 474


                 ....*
gi 518518370 497 YKWWP 501
Cdd:PRK12853 475 RGWRE 479
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
203-500 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 515.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  203 VIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHMLQMLTMIAMEPPSRLLPEDIRDEKVKVL 282
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  283 RSLRPFgSSEDVKTNVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFASRVFVDNFRWAGVPFYIRTGKRLPVKTTE 362
Cdd:pfam02781  82 RSLRPI-TPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  363 IVVEFKSMPTNVYlGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSESDIEPLAMDFCQSCMVGINSPEAYERLLMDAIE 442
Cdd:pfam02781 161 IRIQFKDVPHNLF-RDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 518518370  443 GDSTYFTRWDEVATAWGFVDRIAKAWQQTPdtLETYAAGSWGPDGAHKLLEQDGYKWW 500
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKWR 295
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 6-498 2.56e-164

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 476.55  E-value: 2.56e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   6 VKESLVTQGAVLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEfRNDLYASIQEFSRYKaENDQEW 85
Cdd:PTZ00309  46 VKDEDKSRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVE-RWKKETLARFFKRLD-DRECHL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  86 QAFAEHFEYKSLDINNVDGFHELRQQTEAIEGKFNIP---GNRLFYLALAPELFGSVSKSLKEGGMlDGKGWNRLVIEKP 162
Cdd:PTZ00309 124 EQFLKHISYISGSYDEDEDFKRLNKLIERMEEAFQGPekgGNRLFYLALPPSVFASVCEGIHRGCM-SKNGWVRVIVEKP 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 163 FGYNLESAQELNIEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDH 242
Cdd:PTZ00309 203 FGRDLESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDS 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 243 SGALRDMGQNHMLQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFGssedvKTNVVRGQYT---EGSyrgqqLPGYRQE 319
Cdd:PTZ00309 283 YGIIRDVMQNHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIK-----MEECVLGQYTasaDGS-----IPGYLED 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 320 DKVDPQSNTETYFASRVFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQkhKLEPNLLVIRVNPMEGIYI 399
Cdd:PTZ00309 353 EGVPKDSTTPTFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGD--DTQRNELVIRAQPSEAMYL 430

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 400 KINAKKPGSESDIEPLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYA 479
Cdd:PTZ00309 431 KITAKVPGLSNDLHQTELDLTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYP 510

                        490
                 ....*....|....*....
gi 518518370 480 AGSWGPDGAHKLLEQDGYK 498
Cdd:PTZ00309 511 FGSRGPKEADELIKKNGFK 529
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 16-513 9.59e-163

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 470.67  E-value: 9.59e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  16 VLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRYKAEnDQEWQAFAEHFEYK 95
Cdd:PRK12854  13 VFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEFGARKLD-DGEWARFAKRLRYV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  96 SLDINnVDGFHELRQQTEAIEGKFNIPGNRLFYLALAPELFGSVSKSLKEGGMLDGkgwNRLVIEKPFGYNLESAQELNI 175
Cdd:PRK12854  92 PGGFL-SAGPGALAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEAGLAEG---SRVVMEKPFGTDLASAEALNA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 176 EIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHML 255
Cdd:PRK12854 168 AVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHLF 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 256 QMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFGSSedvktNVVRGQYTegsyrgqqlpGYRQEDKVDPQSNTETYFASR 335
Cdd:PRK12854 248 QVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPA-----EVVRGQYS----------GYRDEPGVAPDSTTETFVALK 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 336 VFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVY-LGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSESDIEP 414
Cdd:PRK12854 313 VWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFpAGSVGAQGPDHLTFDLADNSKVSLSFYGKRPGPGMRLDK 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 415 LAMDF-CQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWgfvdRIAKAWQQTPDTLETYAAGSWGPDGAHKLLE 493
Cdd:PRK12854 393 LSLQFsLKDTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLW----EVSQPLLEDPPPVKPYAPGSWGPNAIHQLAA 468

                        490       500
                 ....*....|....*....|
gi 518518370 494 QDGykwWPVSGQDEdnviWR 513
Cdd:PRK12854 469 PDA---WRLPFERE----WR 481
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 3-503 4.53e-133

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 398.97  E-value: 4.53e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   3 DIPVKESLVTqgavLFIFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRYKAEND 82
Cdd:PLN02333 110 DGNKDESTVS----ITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTCRIDKRENCG 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  83 QEWQAFAEHFEYKSLDINNVDGFHELRQQTEAIEGkfNIPGNRLFYLALAPELFGSVSKSLKEGGMlDGKGWNRLVIEKP 162
Cdd:PLN02333 186 EKMEEFLKRCFYHSGQYDSQEHFAELDKKLKEHEG--GRVSNRLFYLSIPPNIFVDAVKCASSSAS-SVNGWTRVIVEKP 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 163 FGYNLESAQELNIEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDH 242
Cdd:PLN02333 263 FGRDSESSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDN 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 243 SGALRDMGQNHMLQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDvktnVVRGQYTEGSYRGQQLPGYRQEDKV 322
Cdd:PLN02333 343 YGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPI-QLED----VVIGQYKSHTKGGVTYPAYTDDKTV 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 323 DPQSNTETYFASRVFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVY---LGQKHKLEPNLLVIRVNPMEGIYI 399
Cdd:PLN02333 418 PKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYnrnFGTDLDQATNELVIRVQPDEAIYL 497

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 400 KINAKKPGSESDIEPLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYA 479
Cdd:PLN02333 498 KINNKVPGLGMRLDRSNLNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPEYYP 577

                        490       500
                 ....*....|....*....|....
gi 518518370 480 AGSWGPDGAHKLLEQDGYKWWPVS 503
Cdd:PLN02333 578 YGSRGPVGAHYLAARYKVRWGDLS 601
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 19-497 1.23e-131

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 391.39  E-value: 1.23e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  19 IFGATGDLARRKLFPAIYSLYREGKLAED-FAVIGVARRPRTEAEFRNDLYASIQEFSRYKAEndqEWQAFAEHFEYKSL 97
Cdd:PLN02539  22 VLGASGDLAKKKTFPALFNLYRQGFLPPDeVHIFGYARSKITDEELRDRIRGYLKDEKNAPAE---AVSKFLQLIKYVSG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  98 DINNVDGFHELRQ---QTEAIEGKFNIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESAQELN 174
Cdd:PLN02539  99 AYDSEEGFRRLDKeisEHEISKNSAEGSSRRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKDLESAEELS 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 175 IEIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHM 254
Cdd:PLN02539 179 SQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHL 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 255 LQMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFGSSEdvktnVVRGQYtegsyrgqqlPGYRQEDKVDPQSNTETyFAS 334
Cdd:PLN02539 259 LQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEE-----VVLGQY----------EGYRDDPTVPDDSNTPT-FAS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 335 RVF-VDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVYLGQKHKlePNLLVIRVNPMEGIYIKINAKKPGsesdie 413
Cdd:PLN02539 323 VVLrINNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKCQKQG--RNEFVIRLQPSEAMYMKLTVKQPG------ 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 414 pLAMDFCQSCM--------VGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGP 485
Cdd:PLN02539 395 -LEMSTVQSELdlsygqryQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGP 473

                        490
                 ....*....|..
gi 518518370 486 DGAHKLLEQDGY 497
Cdd:PLN02539 474 AEADELLEKAGY 485
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 19-504 3.49e-131

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 393.23  E-value: 3.49e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  19 IFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFSRYKAENDQEWQAFAEHFEYKSLD 98
Cdd:PLN02640  93 VVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLTCRIDQRENCGDKMDQFLKRCFYHSGQ 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370  99 INNVDGFHELRQQTEAIE-GKFNipgNRLFYLALAPELFGSV--SKSLKEGGMldgKGWNRLVIEKPFGYNLESAQELNI 175
Cdd:PLN02640 173 YDSEEDFAELNKKLKEKEaGKLS---NRLFYLSIPPNIFVDVvrCASLRASSE---NGWTRVIVEKPFGRDSESSGELTR 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 176 EIREVFAEEEIYRIDHYLGKEMVQNIEVIRFANAFFEPLWNNKHIANVQITLSETVGVEERGGYYDHSGALRDMGQNHML 255
Cdd:PLN02640 247 CLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLL 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 256 QMLTMIAMEPPSRLLPEDIRDEKVKVLRSLRPFgSSEDvktnVVRGQYTEGSYRGQQLPGYRQEDKVDPQSNTETYFASR 335
Cdd:PLN02640 327 QILALFAMETPVSLDAEDIRNEKVKVLRSMKPL-QLED----VIVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFAAAA 401

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 336 VFVDNFRWAGVPFYIRTGKRLPVKTTEIVVEFKSMPTNVY---LGQKHKLEPNLLVIRVNPMEGIYIKINAKKPGSESDI 412
Cdd:PLN02640 402 LFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYkrnFGTDLDKATNELVLRVQPDEAIYLKINNKVPGLGMRL 481

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370 413 EPLAMDFCQSCMVGINSPEAYERLLMDAIEGDSTYFTRWDEVATAWGFVDRIAKAWQQTPDTLETYAAGSWGPDGAHKLL 492
Cdd:PLN02640 482 DRSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSRGPVGAHYLA 561

                        490
                 ....*....|..
gi 518518370 493 EQDGYKWWPVSG 504
Cdd:PLN02640 562 AKYNVRWGDLSE 573
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
19-200 5.19e-93

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 280.85  E-value: 5.19e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   19 IFGATGDLARRKLFPAIYSLYREGKLAEDFAVIGVARRPRTEAEFRNDLYASIQEFsryKAENDQEWQAFAEHFEYKSLD 98
Cdd:pfam00479   2 IFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEF---KELDEEKWDRFLERLHYVSGD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518518370   99 INNVDGFHELRQQTEAIEGKfnIPGNRLFYLALAPELFGSVSKSLKEGGMLDGKGWNRLVIEKPFGYNLESAQELNIEIR 178
Cdd:pfam00479  79 FDDPESYEKLKERLEEHEDE--TRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARELNDQLA 156

                         170       180
                  ....*....|....*....|..
gi 518518370  179 EVFAEEEIYRIDHYLGKEMVQN 200
Cdd:pfam00479 157 KVFKEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH