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MULTISPECIES: LexA family transcriptional regulator [Enterobacteriaceae]

Protein Classification

LexA family protein( domain architecture ID 11449429)

LexA family protein may function as a transcriptional regulator involved in the repression of one or more genes involved in the response to DNA damage (SOS response), including recA and lexA and/or may contain a S24 peptidase domain such as in the translesion error-prone DNA polymerase V autoproteolytic subunit

Gene Ontology:  GO:0003677|GO:0045892
PubMed:  10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 1-212 4.46e-34

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 120.40  E-value: 4.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082   1 MSTFGSR-------LKSLRKDRKL--TQKQLGKVVGVTDVTIGYWekdqnipggvsLTKLARYfgvSEDFLLTGKEELSN 71
Cdd:COG1974    1 MKKLTKRqreildfIKEYIRERGYppSQREIAEALGLSSSAVHRH-----------LKALEKK---GYLRRDPGKSRAIE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082  72 VAPGNLGAMQIPIISWVQAGTWtSESDarnlEGAVDYILTNGA---HSFGTFALKVRGKSM-EPEFKEGDTIIVDPDLCP 147
Cdd:COG1974   67 LLPASPEVVGLPLLGRVAAGFP-IPAE----ENIEEYLDLPEElvkNPGATFALRVKGDSMiDAGILDGDLVIVDRQLEA 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518535082 148 GPGDYVVAKNGSEyATFKKYRARGvnengeEVFELVPLNPDFAALNSAVEKISIIGVVVEHRRQM 212
Cdd:COG1974  142 ENGDIVVALIDGE-ATVKRLYKEG------GRVRLQPENPAYPPIIIEGDDVEILGVVVGVIRRL 199
 
Name Accession Description Interval E-value
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 1-212 4.46e-34

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 120.40  E-value: 4.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082   1 MSTFGSR-------LKSLRKDRKL--TQKQLGKVVGVTDVTIGYWekdqnipggvsLTKLARYfgvSEDFLLTGKEELSN 71
Cdd:COG1974    1 MKKLTKRqreildfIKEYIRERGYppSQREIAEALGLSSSAVHRH-----------LKALEKK---GYLRRDPGKSRAIE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082  72 VAPGNLGAMQIPIISWVQAGTWtSESDarnlEGAVDYILTNGA---HSFGTFALKVRGKSM-EPEFKEGDTIIVDPDLCP 147
Cdd:COG1974   67 LLPASPEVVGLPLLGRVAAGFP-IPAE----ENIEEYLDLPEElvkNPGATFALRVKGDSMiDAGILDGDLVIVDRQLEA 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518535082 148 GPGDYVVAKNGSEyATFKKYRARGvnengeEVFELVPLNPDFAALNSAVEKISIIGVVVEHRRQM 212
Cdd:COG1974  142 ENGDIVVALIDGE-ATVKRLYKEG------GRVRLQPENPAYPPIIIEGDDVEILGVVVGVIRRL 199
Peptidase_S24 pfam00717
Peptidase S24-like;
83-206 1.17e-23

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 90.73  E-value: 1.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082   83 PIISWVQAGTWTSESDarNLEGAVDYILTNGAHSFGTFALKVRGKSMEPEFKEGDTIIVDPDLCPGPGDYVVAKNGSEyA 162
Cdd:pfam00717   1 PLIGRVAAGAPILAEE--EIEGYLPLPESLLSPPGNLFALRVKGDSMEPGIPDGDLVLVDPSREARNGDIVVARLDGE-A 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 518535082  163 TFKKYrargVNENGEevFELVPLNPDFAALN-SAVEKISIIGVVV 206
Cdd:pfam00717  78 TVKRL----YRDGGG--IRLISLNPEYPPIElPAEDDVEIIGRVV 116
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 120-206 9.69e-22

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 84.92  E-value: 9.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082 120 FALKVRGKSMEPEFKEGDTIIVDPDLCPGPGDYVVAKNGSEyATFKKYRARGVNengeeVFELVPLNPDFAALNSAVEKI 199
Cdd:cd06529    1 FALRVKGDSMEPTIPDGDLVLVDPSDTPRDGDIVVARLDGE-LTVKRLQRRGGG-----RLRLISDNPAYPPIEIDEEEL 74


                 ....*..
gi 518535082 200 SIIGVVV 206
Cdd:cd06529   75 EIVGVVG 81
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 3-74 5.90e-13

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 63.33  E-value: 5.90e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518535082   3 TFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFLLTGKEELSNVAP 74
Cdd:PRK09706   5 TLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLFGDEDKQPTPP 76
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
7-62 8.26e-12

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 58.30  E-value: 8.26e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 518535082     7 RLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFL 62
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
 
Name Accession Description Interval E-value
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 1-212 4.46e-34

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 120.40  E-value: 4.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082   1 MSTFGSR-------LKSLRKDRKL--TQKQLGKVVGVTDVTIGYWekdqnipggvsLTKLARYfgvSEDFLLTGKEELSN 71
Cdd:COG1974    1 MKKLTKRqreildfIKEYIRERGYppSQREIAEALGLSSSAVHRH-----------LKALEKK---GYLRRDPGKSRAIE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082  72 VAPGNLGAMQIPIISWVQAGTWtSESDarnlEGAVDYILTNGA---HSFGTFALKVRGKSM-EPEFKEGDTIIVDPDLCP 147
Cdd:COG1974   67 LLPASPEVVGLPLLGRVAAGFP-IPAE----ENIEEYLDLPEElvkNPGATFALRVKGDSMiDAGILDGDLVIVDRQLEA 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518535082 148 GPGDYVVAKNGSEyATFKKYRARGvnengeEVFELVPLNPDFAALNSAVEKISIIGVVVEHRRQM 212
Cdd:COG1974  142 ENGDIVVALIDGE-ATVKRLYKEG------GRVRLQPENPAYPPIIIEGDDVEILGVVVGVIRRL 199
Peptidase_S24 pfam00717
Peptidase S24-like;
83-206 1.17e-23

Peptidase S24-like;


Pssm-ID: 425835  Cd Length: 116  Bit Score: 90.73  E-value: 1.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082   83 PIISWVQAGTWTSESDarNLEGAVDYILTNGAHSFGTFALKVRGKSMEPEFKEGDTIIVDPDLCPGPGDYVVAKNGSEyA 162
Cdd:pfam00717   1 PLIGRVAAGAPILAEE--EIEGYLPLPESLLSPPGNLFALRVKGDSMEPGIPDGDLVLVDPSREARNGDIVVARLDGE-A 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 518535082  163 TFKKYrargVNENGEevFELVPLNPDFAALN-SAVEKISIIGVVV 206
Cdd:pfam00717  78 TVKRL----YRDGGG--IRLISLNPEYPPIElPAEDDVEIIGRVV 116
S24_LexA-like cd06529
Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of ...
 120-206 9.69e-22

Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.


Pssm-ID: 119397 [Multi-domain]  Cd Length: 81  Bit Score: 84.92  E-value: 9.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082 120 FALKVRGKSMEPEFKEGDTIIVDPDLCPGPGDYVVAKNGSEyATFKKYRARGVNengeeVFELVPLNPDFAALNSAVEKI 199
Cdd:cd06529    1 FALRVKGDSMEPTIPDGDLVLVDPSDTPRDGDIVVARLDGE-LTVKRLQRRGGG-----RLRLISDNPAYPPIEIDEEEL 74


                 ....*..
gi 518535082 200 SIIGVVV 206
Cdd:cd06529   75 EIVGVVG 81
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-68 6.06e-17

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 72.34  E-value: 6.06e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518535082   1 MSTFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFLLTGKEE 68
Cdd:COG1396    5 KKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADE 72
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-67 2.57e-15

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 67.57  E-value: 2.57e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518535082   1 MSTFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFLLTGKE 67
Cdd:COG1476    2 KKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLEE 68
Peptidase_S24_S26 cd06462
The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal ...
 120-205 4.57e-15

The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.


Pssm-ID: 119396 [Multi-domain]  Cd Length: 84  Bit Score: 67.67  E-value: 4.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082 120 FALKVRGKSMEPEFKEGDTIIVDPDLC-PGPGDYVVAKNGSEYATFKKYRARGvnenGEEVFELVPLNPDFAALN-SAVE 197
Cdd:cd06462    1 FALRVEGDSMEPTIPDGDLVLVDKSSYePKRGDIVVFRLPGGELTVKRVIGLP----GEGHYFLLGDNPNSPDSRiDGPP 76


                 ....*...
gi 518535082 198 KISIIGVV 205
Cdd:cd06462   77 ELDIVGVV 84
COG2932 COG2932
Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: ...
 82-206 2.02e-13

Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains [Mobilome: prophages, transposons];


Pssm-ID: 442176  Cd Length: 121  Bit Score: 64.21  E-value: 2.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082  82 IPIIS-WVQAGTWTSESDarnlEGAVDYILTNGAHSFGTFALKVRGKSMEPEFKEGDTIIVDPDLC-PGPGDYVVAKNGS 159
Cdd:COG2932    1 VPLYDgEASAGGGAFNEV----EEPVDKLEFPGLPPDNLFAVRVSGDSMEPTIRDGDIVLVDPSDTeIRDGGIYVVRTDG 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 518535082 160 EYaTFKKYRARgvnenGEEVFELVPLNPDFAAL---NSAVEKISIIGVVV 206
Cdd:COG2932   77 EL-LVKRLQRR-----PDGKLRLISDNPAYPPIeipPEDADEIEIIGRVV 120
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-62 5.64e-13

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 61.41  E-value: 5.64e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 518535082   5 GSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFL 62
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 3-74 5.90e-13

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 63.33  E-value: 5.90e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518535082   3 TFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFLLTGKEELSNVAP 74
Cdd:PRK09706   5 TLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLFGDEDKQPTPP 76
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 5-68 3.78e-12

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 59.22  E-value: 3.78e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518535082    5 GSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFLLTGKEE 68
Cdd:pfam12844   1 GERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGEGE 64
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 8-62 5.93e-12

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 58.32  E-value: 5.93e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 518535082    8 LKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFL 62
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
7-62 8.26e-12

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 58.30  E-value: 8.26e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 518535082     7 RLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFL 62
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 2-58 7.96e-11

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 55.71  E-value: 7.96e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 518535082   2 STFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVS 58
Cdd:COG1813   11 EDYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGIS 67
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 4-60 4.47e-07

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 45.60  E-value: 4.47e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 518535082    4 FGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEK-DQNIPGGVSLTKLARYFGVSED 60
Cdd:pfam13560   2 LGARLRRLRERAGLSQEALARRLGVSRSTLSRLETgRRGRPSPAVVERLARALGVDGA 59
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 1-118 4.98e-07

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 49.35  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082   1 MSTFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIG-----YWEKDQNIPGGVSLTKLARYFGVSEDFLLtGKEELSNVAPG 75
Cdd:PRK13355   1 KTTFAERLKQAMKARGLKQEDLVHAAEARGVKLGkshisQYVSGKTGPRRDVLPFLAAILGVSEDWLL-GGESPADQESD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 518535082  76 NLGAMQipiiSWVQAGTWTSESDARNLEGAVDYILTNGAHSFG 118
Cdd:PRK13355  80 ASAVVE----SAPNSHLADPSAPTTPISQTSSEISIGNRRTFK 118
PRK10276 PRK10276
translesion error-prone DNA polymerase V autoproteolytic subunit;
115-205 5.35e-06

translesion error-prone DNA polymerase V autoproteolytic subunit;


Pssm-ID: 182350  Cd Length: 139  Bit Score: 44.40  E-value: 5.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082 115 HSFGTFALKVRGKSM-EPEFKEGDTIIVDPDLCPGPGDYVVAKNGSEYaTFKKYRARgvnengeEVFELVPLNPDFAALN 193
Cdd:PRK10276  47 HPSATYFVKASGDSMiDAGISDGDLLIVDSAITASHGDIVIAAVDGEF-TVKKLQLR-------PTVQLIPMNSAYSPIT 118

                         90
                 ....*....|...
gi 518535082 194 -SAVEKISIIGVV 205
Cdd:PRK10276 119 iSSEDTLDVFGVV 131
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 3-63 2.36e-05

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 41.54  E-value: 2.36e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518535082   3 TFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFLL 63
Cdd:COG3620   17 TLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVL 77
PHA01976 PHA01976
helix-turn-helix protein
 3-68 6.54e-05

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 39.94  E-value: 6.54e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518535082   3 TFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLARYFGVSEDFLLTGKEE 68
Cdd:PHA01976   2 SFAIQLIKARNARAWSAPELSRRAGVRHSLIYDFEADKRLPNLKTLLRLADALGVTLDWLCGRCGE 67
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
5-52 1.12e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 39.15  E-value: 1.12e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 518535082   5 GSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQNIPGGVSLTKLA 52
Cdd:COG2944    8 PEEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRKPSGAALKLLR 55
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-63 4.45e-04

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 37.48  E-value: 4.45e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518535082   1 MSTFGSRLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQ--NIPGGV----SLTKLARYFGVSEDFLL 63
Cdd:COG1426    3 LETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDfdALPGPVyvrgFLRSYARALGLDPEELL 71
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 13-63 4.78e-03

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 35.17  E-value: 4.78e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 518535082  13 KDRKLTQKQLGKVVGVTDVTIGYWEKdqnipGGVSLT-----KLARYFGVSEDFLL 63
Cdd:COG3093   19 EPLGLSQTELAKALGVSRQRISEILN-----GKRAITadtalRLARAFGTSAEFWL 69
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
7-62 9.94e-03

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 33.58  E-value: 9.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518535082   7 RLKSLRKDRKLTQKQLGKVVGVTDVTIGYWEKDQniPGGVS---LTKLARYFGVS-EDFL 62
Cdd:COG3655    5 KLDELLAERGMTKKELAEATGISRATLSRLKNGK--AKAVRldtLEKICKALDCQpGDLL 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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