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Conserved domains on  [gi|518550425|ref|WP_019720632|]
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glucose-6-phosphate dehydrogenase [Heyndrickxia coagulans]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11417513)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 2-490 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 880.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   2 QTTETPKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSI---LSAREHAEQLEAF 78
Cdd:COG0364    3 QMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALeefSRKPFDEEVWERF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  79 AAHFYYQPHDVTDSNSYIQLKQLADELDEKYqLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSLE 158
Cdd:COG0364   83 LERLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 159 SAKQLNSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRD 238
Cdd:COG0364  162 SARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 239 MVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVPAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRTE 318
Cdd:COG0364  242 MVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 319 TFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQH 398
Cdd:COG0364  322 TFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLG 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 399 METTPVQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAAD 478
Cdd:COG0364  402 MRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAAD 481

                        490
                 ....*....|..
gi 518550425 479 ELLEKDGFFWWP 490
Cdd:COG0364  482 ALLARDGRSWRE 493
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 2-490 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 880.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   2 QTTETPKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSI---LSAREHAEQLEAF 78
Cdd:COG0364    3 QMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALeefSRKPFDEEVWERF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  79 AAHFYYQPHDVTDSNSYIQLKQLADELDEKYqLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSLE 158
Cdd:COG0364   83 LERLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 159 SAKQLNSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRD 238
Cdd:COG0364  162 SARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 239 MVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVPAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRTE 318
Cdd:COG0364  242 MVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 319 TFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQH 398
Cdd:COG0364  322 TFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLG 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 399 METTPVQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAAD 478
Cdd:COG0364  402 MRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAAD 481

                        490
                 ....*....|..
gi 518550425 479 ELLEKDGFFWWP 490
Cdd:COG0364  482 ALLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-489 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 876.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   1 MQTTETPKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSI---LSAREHAEQLEA 77
Cdd:PRK05722   2 RLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALkefARTPFDEEVWER 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  78 FAAHFYYQPHDVTDSNSYIQLKQLADELDEKYQLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSL 157
Cdd:PRK05722  82 FLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 158 ESAKQLNSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALR 237
Cdd:PRK05722 162 ASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 238 DMVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVPAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRT 317
Cdd:PRK05722 242 DMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTT 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 318 ETFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQ 397
Cdd:PRK05722 322 ETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGE 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 398 HMETTPVQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAA 477
Cdd:PRK05722 402 GMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAA 481

                        490
                 ....*....|..
gi 518550425 478 DELLEKDGFFWW 489
Cdd:PRK05722 482 DALLARDGRSWR 493
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 7-490 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 742.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425    7 PKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSIL--SAREHAEQLEAFAAHFYY 84
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIkfETDEIDEQWDEFAQRLSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   85 QPHDVTDSNSYIQLKQLADELDEKYQLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSLESAKQLN 164
Cdd:TIGR00871  81 VSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  165 SQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNHM 244
Cdd:TIGR00871 161 KALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  245 LQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDvpAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRTETFVAGK 324
Cdd:TIGR00871 241 LQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALK 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  325 LMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNHELNP-NLLVIHIQPEEGISLHLNAKKPGQHMETTP 403
Cdd:TIGR00871 319 LEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETRP 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  404 VQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWE-NKPISFPNYKSGSMGPKAADELLE 482
Cdd:TIGR00871 399 VKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAaNKGPSPPNYPAGSWGPKEADELIR 478


                  ....*...
gi 518550425  483 KDGFFWWP 490
Cdd:TIGR00871 479 KDGRSWRK 486
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
193-489 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 539.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  193 VIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVL 272
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  273 RALRPIEGKDVPAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRTETFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKI 352
Cdd:pfam02781  82 RSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  353 VVQFKDIPMNLyYNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQHMETTPVQLSFASSSKNGINTPEAYEKLIHDCLMG 432
Cdd:pfam02781 162 RIQFKDVPHNL-FRDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 518550425  433 DATNFTHWDEVALSWSFVDKISKVWENKPisFPNYKSGSMGPKAADELLEKDGFFWW 489
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 2-490 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 880.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   2 QTTETPKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSI---LSAREHAEQLEAF 78
Cdd:COG0364    3 QMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALeefSRKPFDEEVWERF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  79 AAHFYYQPHDVTDSNSYIQLKQLADELDEKYqLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSLE 158
Cdd:COG0364   83 LERLHYVSGDFTDPEGYERLKELLEELDEER-TPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDLA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 159 SAKQLNSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRD 238
Cdd:COG0364  162 SARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 239 MVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVPAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRTE 318
Cdd:COG0364  242 MVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTE 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 319 TFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQH 398
Cdd:COG0364  322 TFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLG 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 399 METTPVQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAAD 478
Cdd:COG0364  402 MRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAAD 481

                        490
                 ....*....|..
gi 518550425 479 ELLEKDGFFWWP 490
Cdd:COG0364  482 ALLARDGRSWRE 493
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-489 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 876.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   1 MQTTETPKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSI---LSAREHAEQLEA 77
Cdd:PRK05722   2 RLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALkefARTPFDEEVWER 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  78 FAAHFYYQPHDVTDSNSYIQLKQLADELDEKYQLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSL 157
Cdd:PRK05722  82 FLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 158 ESAKQLNSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALR 237
Cdd:PRK05722 162 ASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 238 DMVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVPAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRT 317
Cdd:PRK05722 242 DMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTT 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 318 ETFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQ 397
Cdd:PRK05722 322 ETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGE 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 398 HMETTPVQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAA 477
Cdd:PRK05722 402 GMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAA 481

                        490
                 ....*....|..
gi 518550425 478 DELLEKDGFFWW 489
Cdd:PRK05722 482 DALLARDGRSWR 493
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 7-490 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 742.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425    7 PKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSIL--SAREHAEQLEAFAAHFYY 84
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIkfETDEIDEQWDEFAQRLSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   85 QPHDVTDSNSYIQLKQLADELDEKYQLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSLESAKQLN 164
Cdd:TIGR00871  81 VSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  165 SQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNHM 244
Cdd:TIGR00871 161 KALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  245 LQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDvpAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRTETFVAGK 324
Cdd:TIGR00871 241 LQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALK 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  325 LMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNHELNP-NLLVIHIQPEEGISLHLNAKKPGQHMETTP 403
Cdd:TIGR00871 319 LEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETRP 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  404 VQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWE-NKPISFPNYKSGSMGPKAADELLE 482
Cdd:TIGR00871 399 VKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAaNKGPSPPNYPAGSWGPKEADELIR 478


                  ....*...
gi 518550425  483 KDGFFWWP 490
Cdd:TIGR00871 479 KDGRSWRK 486
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
1-490 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 662.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   1 MQTTETPKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSIlsaREHAEQ------ 74
Cdd:PRK12853   1 ADTAPAPPCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESL---RAFGADgfddav 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  75 LEAFAAHFYYQPHDVTDSNSYIQLKQLADEldekyqlEGNRIFYLAMAPEYFGTISDHLKSDGLTAtnGFKRLVIEKPFG 154
Cdd:PRK12853  78 WDRLAARLSYVQGDVTDPADYARLAEALGP-------GGNPVFYLAVPPSLFAPVVENLGAAGLLP--EGRRVVLEKPFG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 155 HSLESAKQLNSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASG 234
Cdd:PRK12853 149 HDLASARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATG 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 235 ALRDMVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVPAyfVRGQYGPGEIGGKKVPGYREELNVAPD 314
Cdd:PRK12853 229 ALRDMVQNHLLQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDVHT--VRGQYTAGTVGGEPVPGYREEPGVDPD 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 315 SRTETFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMnLYYNTNHELNPNLLVIHIQPEEGISLHLNAKK 394
Cdd:PRK12853 307 SRTETFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPH-ALFRGTGVEPPNRLVIRLQPDEGISLELNVKR 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 395 PGQHMETTPVQLSFAssSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGP 474
Cdd:PRK12853 386 PGPGMRLRPVELDAD--YADDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGP 463

                        490
                 ....*....|....*.
gi 518550425 475 KAADELLEKDGFFWWP 490
Cdd:PRK12853 464 AAADALLARDGRGWRE 479
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
193-489 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 539.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  193 VIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVL 272
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  273 RALRPIEGKDVPAYFVRGQYGPGEIGGKKVPGYREELNVAPDSRTETFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKI 352
Cdd:pfam02781  82 RSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  353 VVQFKDIPMNLyYNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQHMETTPVQLSFASSSKNGINTPEAYEKLIHDCLMG 432
Cdd:pfam02781 162 RIQFKDVPHNL-FRDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 518550425  433 DATNFTHWDEVALSWSFVDKISKVWENKPisFPNYKSGSMGPKAADELLEKDGFFWW 489
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKWR 295
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 3-485 1.16e-170

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 489.93  E-value: 1.16e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   3 TTETPKSLFMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSILSAREH---AEQLEAFA 79
Cdd:PRK12854   6 TGPAPPTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEFGARkldDGEWARFA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  80 AHFYYQPHDVTDSNSyiqlKQLADELDEKYQLEG---NRIFYLAMAPEYFGTISDHLKSDGLTATNgfkRLVIEKPFGHS 156
Cdd:PRK12854  86 KRLRYVPGGFLSAGP----GALAAAVAAARAELGgdaRLVHYLAVPPSAFLDVTRALGEAGLAEGS---RVVMEKPFGTD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 157 LESAKQLNSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGAL 236
Cdd:PRK12854 159 LASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAY 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 237 RDMVQNHMLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVpayfVRGQYGpgeiggkkvpGYREELNVAPDSR 316
Cdd:PRK12854 239 RDMVVTHLFQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEV----VRGQYS----------GYRDEPGVAPDST 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 317 TETFVAGKLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLY-YNTNHELNPNLLVIHIQPEEGISLHLNAKKP 395
Cdd:PRK12854 305 TETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFpAGSVGAQGPDHLTFDLADNSKVSLSFYGKRP 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 396 GQHMETTPVQLSFASSSKNGINTP-EAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISkvwENKPISFPnYKSGSMGP 474
Cdd:PRK12854 385 GPGMRLDKLSLQFSLKDTGPKGDVlEAYERLILDALRGDHTLFTTADGIESLWEVSQPLL---EDPPPVKP-YAPGSWGP 460

                        490
                 ....*....|.
gi 518550425 475 KAADELLEKDG 485
Cdd:PRK12854 461 NAIHQLAAPDA 471
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 11-486 1.51e-149

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 438.41  E-value: 1.51e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  11 FMLFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTD--EIFRAHIKDSILSAREHAEQLEAFAAHFYYQPHD 88
Cdd:PTZ00309  57 IIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDveRWKKETLARFFKRLDDRECHLEQFLKHISYISGS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  89 VTDSNSYIQLKQLADELDEKYQLE---GNRIFYLAMAPEYFGTISDHLKSdGLTATNGFKRLVIEKPFGHSLESAKQLNS 165
Cdd:PTZ00309 137 YDEDEDFKRLNKLIERMEEAFQGPekgGNRLFYLALPPSVFASVCEGIHR-GCMSKNGWVRVIVEKPFGRDLESSEELSN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 166 QIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNHML 245
Cdd:PTZ00309 216 QLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 246 QMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVpayfVRGQYGPGEIGgkKVPGYREELNVAPDSRTETFVAGKL 325
Cdd:PTZ00309 296 QILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEEC----VLGQYTASADG--SIPGYLEDEGVPKDSTTPTFAAAVL 369

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 326 MIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYYNTNheLNPNLLVIHIQPEEGISLHLNAKKPGQHMETTPVQ 405
Cdd:PTZ00309 370 HINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDD--TQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTE 447

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 406 LSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAADELLEKDG 485
Cdd:PTZ00309 448 LDLTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNG 527


                 .
gi 518550425 486 F 486
Cdd:PTZ00309 528 F 528
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 15-486 9.53e-130

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 386.00  E-value: 9.53e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  15 GATGDLAKRKLFPSLYNLYRKGRL-SEHFAVIGTARREWTDEIFRAHIKDSILSARE-HAEQLEAFAAHFYYQPHDVTDS 92
Cdd:PLN02539  24 GASGDLAKKKTFPALFNLYRQGFLpPDEVHIFGYARSKITDEELRDRIRGYLKDEKNaPAEAVSKFLQLIKYVSGAYDSE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  93 NSYIQL-KQLADELDEKYQLEG--NRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSLESAKQLNSQIRK 169
Cdd:PLN02539 104 EGFRRLdKEISEHEISKNSAEGssRRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKDLESAEELSSQIGE 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 170 SFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNHMLQMVA 249
Cdd:PLN02539 184 LFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHLLQVLC 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 250 LLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVpayfVRGQYgpgeiggkkvPGYREELNVAPDSRTETFVAGKLMIDN 329
Cdd:PLN02539 264 LVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEV----VLGQY----------EGYRDDPTVPDDSNTPTFASVVLRINN 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 330 FRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLYynTNHELNPNLLVIHIQPEEGISLHLNAKKPGQHMETTPVQLSFA 409
Cdd:PLN02539 330 ERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIF--KCQKQGRNEFVIRLQPSEAMYMKLTVKQPGLEMSTVQSELDLS 407

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518550425 410 SSSK-NGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAADELLEKDGF 486
Cdd:PLN02539 408 YGQRyQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGPAEADELLEKAGY 485
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 15-488 3.53e-127

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 383.17  E-value: 3.53e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  15 GATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSI---LSAREH-AEQLEAFAAHFYYQphdvt 90
Cdd:PLN02333 124 GASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLtcrIDKRENcGEKMEEFLKRCFYH----- 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  91 dSNSYIQLKQLAdELDEKY-QLEG----NRIFYLAMAPEYFgtiSDHLKSDGLTAT--NGFKRLVIEKPFGHSLESAKQL 163
Cdd:PLN02333 199 -SGQYDSQEHFA-ELDKKLkEHEGgrvsNRLFYLSIPPNIF---VDAVKCASSSASsvNGWTRVIVEKPFGRDSESSAAL 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 164 NSQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNH 243
Cdd:PLN02333 274 TKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNH 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 244 MLQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVpayfVRGQYGPGEIGGKKVPGYREELNVAPDSRTETFVAG 323
Cdd:PLN02333 354 LLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDV----VIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAAA 429

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 324 KLMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLY---YNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQHME 400
Cdd:PLN02333 430 ALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYnrnFGTDLDQATNELVIRVQPDEAIYLKINNKVPGLGMR 509

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 401 TTPVQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAADEL 480
Cdd:PLN02333 510 LDRSNLNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPEYYPYGSRGPVGAHYL 589


                 ....*...
gi 518550425 481 LEKDGFFW 488
Cdd:PLN02333 590 AARYKVRW 597
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 15-488 3.91e-124

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 374.35  E-value: 3.91e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  15 GATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSI---LSAREHAE-QLEAFAAHFYYQPHDVT 90
Cdd:PLN02640  95 GASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLtcrIDQRENCGdKMDQFLKRCFYHSGQYD 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425  91 DSNSYIQLKQladELDEKyqlEG----NRIFYLAMAPEYFgtiSDHLKSDGLTA--TNGFKRLVIEKPFGHSLESAKQLN 164
Cdd:PLN02640 175 SEEDFAELNK---KLKEK---EAgklsNRLFYLSIPPNIF---VDVVRCASLRAssENGWTRVIVEKPFGRDSESSGELT 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 165 SQIRKSFSEDQIYRIDHYLGKAMVQNIEVIRFANALFEPLWNNRYISNIQITSSEMLGVEERARYYEASGALRDMVQNHM 244
Cdd:PLN02640 246 RCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHL 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 245 LQMVALLAMEPPISLTTNEIRSEKVRVLRALRPIEGKDVpayfVRGQYGPGEIGGKKVPGYREELNVAPDSRTETFVAGK 324
Cdd:PLN02640 326 LQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDV----IVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFAAAA 401

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 325 LMIDNFRWAGVPFYIRTGKRMAAKSTKIVVQFKDIPMNLY---YNTNHELNPNLLVIHIQPEEGISLHLNAKKPGQHMET 401
Cdd:PLN02640 402 LFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYkrnFGTDLDKATNELVLRVQPDEAIYLKINNKVPGLGMRL 481

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425 402 TPVQLSFASSSKNGINTPEAYEKLIHDCLMGDATNFTHWDEVALSWSFVDKISKVWENKPISFPNYKSGSMGPKAADELL 481
Cdd:PLN02640 482 DRSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSRGPVGAHYLA 561


                 ....*..
gi 518550425 482 EKDGFFW 488
Cdd:PLN02640 562 AKYNVRW 568
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
13-190 1.28e-98

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 294.72  E-value: 1.28e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   13 LFGATGDLAKRKLFPSLYNLYRKGRLSEHFAVIGTARREWTDEIFRAHIKDSILSAREHA-EQLEAFAAHFYYQPHDVTD 91
Cdd:pfam00479   2 IFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFKELDeEKWDRFLERLHYVSGDFDD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518550425   92 SNSYIQLKQLADELDEkyQLEGNRIFYLAMAPEYFGTISDHLKSDGLTATNGFKRLVIEKPFGHSLESAKQLNSQIRKSF 171
Cdd:pfam00479  82 PESYEKLKERLEEHED--ETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARELNDQLAKVF 159

                         170
                  ....*....|....*....
gi 518550425  172 SEDQIYRIDHYLGKAMVQN 190
Cdd:pfam00479 160 KEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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