|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
5-878 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1663.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 5 KNLSTKYNPQEVEAGRYQNWLDEDLFKPSGDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPG 84
Cdd:COG0525 1 MELPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 85 MDHAGIATQAKVEEKLREQGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVS 164
Cdd:COG0525 81 TDHAGIATQAVVERQLAEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 165 LYEKELIYRGEYIINWDPQARTALSDIEVIHKEIEGAFYHMSYELADGSGVVEIATTRPETMLGDTAIAVHPEDERYQAL 244
Cdd:COG0525 161 LYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGYIVVATTRPETMLGDTAVAVHPEDERYKHL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 245 IGKKVILPLVNKEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYQGMDRFAARKA 324
Cdd:COG0525 241 IGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGLDRFEARKA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 325 IVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQETDDaVEFFPPRFNQTFLRWMENVHD 404
Cdd:COG0525 321 IVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGE-IKFVPERWEKTYFHWMENIRD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 405 WVISRQLWWGHQIPAWYHKEtGEMYVGMEAP-----ADSENWLQDPDVLDTWFSSALWPFSTMGWPdEDNEDYQRYFPTS 479
Cdd:COG0525 400 WCISRQLWWGHRIPAWYCPD-GEVYVARTEPeacakAGSVNLTQDEDVLDTWFSSALWPFSTLGWP-EKTEDLKYFYPTS 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 480 TLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQ 559
Cdd:COG0525 478 VLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGR 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 560 DVRFSYEKMDASWNFINKIWNASRFVIMNVEGMTVEDIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYN 639
Cdd:COG0525 558 DIKFDEERVEGYRNFANKLWNASRFVLMNLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYD 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 640 FIWDDFCDWYIEMSKETLYGEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIP--HKGTSLVVADYPVVQPEY 717
Cdd:COG0525 638 FVWNEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPprKEGESIMLAPWPEADEEL 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 718 DDEAASKGMEVLKELIRSVRNIRSEVNTPLSKPITLLIKTNDPKIDQFLNENTSYIERFCNPEELTISSDvTAPDLAMSA 797
Cdd:COG0525 718 IDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVD-EKPEGAASA 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 798 VLTGAEIFLPLAGLINIEEEIQRLEKELAKWTGEVKRVQGKLSNERFVSNAPDDVVEAERAKEKDYLEKQAAVNERIAQL 877
Cdd:COG0525 797 VVGGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARL 876
|
.
gi 518552761 878 K 878
Cdd:COG0525 877 K 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
3-879 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1647.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 3 EEKNLSTKYNPQEVEAGRYQNWLDEDLFKPSGDKKaKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWL 82
Cdd:PRK05729 1 MMMELPKTYDPKEVEAKWYQKWEEKGYFKPDDNSK-KPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 83 PGMDHAGIATQAKVEEKLREQGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVF 162
Cdd:PRK05729 80 PGTDHAGIATQMVVERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 163 VSLYEKELIYRGEYIINWDPQARTALSDIEVIHKEIEGAFYHMSYELADGSGVVEIATTRPETMLGDTAIAVHPEDERYQ 242
Cdd:PRK05729 160 VRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDYLVVATTRPETMLGDTAVAVNPEDERYK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 243 ALIGKKVILPLVNKEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYQGMDRFAAR 322
Cdd:PRK05729 240 HLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEAR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 323 KAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQETDDaVEFFPPRFNQTFLRWMENV 402
Cdd:PRK05729 320 KAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGE-IKFVPERWEKTYFHWMENI 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 403 HDWVISRQLWWGHQIPAWYHKEtGEMYVGMEAPADSEN--WLQDPDVLDTWFSSALWPFSTMGWPDeDNEDYQRYFPTST 480
Cdd:PRK05729 399 QDWCISRQLWWGHRIPAWYDED-GEVYVGREEPEAREKalLTQDEDVLDTWFSSALWPFSTLGWPE-KTEDLKRFYPTSV 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 481 LVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQD 560
Cdd:PRK05729 477 LVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRD 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 561 VRFSYEKMDASWNFINKIWNASRFVIMNVEGMTVEDIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNF 640
Cdd:PRK05729 557 IRFDEERVEGYRNFANKLWNASRFVLMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEF 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 641 IWDDFCDWYIEMSKETLYGEdevAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPHKGT--SLVVADYPVVQPEYD 718
Cdd:PRK05729 637 IWNEFCDWYLELAKPVLQEA---AKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIeeSIMLAPWPEADEAID 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 719 DEAASKgMEVLKELIRSVRNIRSEVNTPLSKPITLLIKTNDPKIDQFLNENTSYIERFCNPEELTISSDV-TAPDLAMSA 797
Cdd:PRK05729 714 EAAEAE-FEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDeEAPEGAASA 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 798 VLTGAEIFLPLAGLINIEEEIQRLEKELAKWTGEVKRVQGKLSNERFVSNAPDDVVEAERAKEKDYLEKQAAVNERIAQL 877
Cdd:PRK05729 793 VVGGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARL 872
|
..
gi 518552761 878 KS 879
Cdd:PRK05729 873 KA 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
9-861 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1266.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 9 TKYNPQEVEAGRYQNWLDEDLFKPSGDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHA 88
Cdd:TIGR00422 3 KDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 89 GIATQAKVEEKLREQGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEK 168
Cdd:TIGR00422 83 GIATQVKVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 169 ELIYRGEYIINWDPQARTALSDIEVIHKEIEGAFYHMSYELADGS-GVVEIATTRPETMLGDTAIAVHPEDERYQALIGK 247
Cdd:TIGR00422 163 GLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSkDYLVVATTRPETMFGDTAVAVHPEDERYKHLIGK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 248 KVILPLVNKEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYQGMDRFAARKAIVA 327
Cdd:TIGR00422 243 KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 328 DLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQEtDDAVEFFPPRFNQTFLRWMENVHDWVI 407
Cdd:TIGR00422 323 DLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAE-EGEIKFVPKRMEKRYLNWLRNIKDWCI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 408 SRQLWWGHQIPAWYHKETGEMYVGM-EAPADSE-------NWLQDPDVLDTWFSSALWPFSTMGWPDEDnEDYQRYFPTS 479
Cdd:TIGR00422 402 SRQLIWGHRIPVWYCKECGEVYVAKeEPLPDDKtntgpsvELEQDTDVLDTWFSSSLWPFSTLGWPDET-KDLKKFYPTD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 480 TLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQ 559
Cdd:TIGR00422 481 LLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGD 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 560 DVRFSYEKMDASWNFINKIWNASRFVIMNVEGMTvEDIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYN 639
Cdd:TIGR00422 561 DINFDWKRVESARNFLNKLWNASRFVLMNLSDDL-ELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYE 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 640 FIWDDFCDWYIEMSKETLYGEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPHKGTSLVVADYPVVQPEYDD 719
Cdd:TIGR00422 640 FIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYPVVDAEFVD 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 720 EAASKGMEVLKELIRSVRNIRSEVNTPLSKPITLLIKTNDPKIDQFLNENTSYIERFCNPEELTISSDVTAPDLAMSAVL 799
Cdd:TIGR00422 720 EEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVELV 799
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518552761 800 TGAEIFLPLAGLINIEEEIQRLEKELAKWTGEVKRVQGKLSNERFVSNAPDDVVEAERAKEK 861
Cdd:TIGR00422 800 PGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
1-877 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 979.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 1 MTEEKNLSTKYNPQEVEAGRYQNWLDEDLFK-PSGDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDT 79
Cdd:PRK14900 9 NENRTELAKGYEHREVEARWYPFWQERGYFHgDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 80 LWLPGMDHAGIATQAKVEEKLRE-QGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAV 158
Cdd:PRK14900 89 LWLPGTDHAGIATQMIVEKELKKtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 159 RKVFVSLYEKELIYRGEYIINWDPQARTALSDIEVIHKEI-EGAFYHMSYELADGSGVVEIATTRPETMLGDTAIAVHPE 237
Cdd:PRK14900 169 REVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAhQGELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 238 DERYQALIGKKVILPLVNKEIPIIAD-EYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYQGM 316
Cdd:PRK14900 249 DPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 317 DRFAARKAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQEtDDAVEFFPPRFNQTFL 396
Cdd:PRK14900 329 DRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVE-QGRTRFIPEQWTNTYM 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 397 RWMENVHDWVISRQLWWGHQIPAWYHKEtGEMYVGMEAPAD-----SENWLQDPDVLDTWFSSALWPFSTMGWPdEDNED 471
Cdd:PRK14900 408 AWMRNIHDWCISRQLWWGHQIPAWYCPD-GHVTVARETPEAcstcgKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDT 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 472 YQRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFL 551
Cdd:PRK14900 486 LRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTL 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 552 SNGSAPGQDVRFSYEKMDASWNFINKIWNASRFVIMNVEGMTVEDIDLS-GEKTVADRWILTRLNETIAKVTDLFEQFEF 630
Cdd:PRK14900 566 AALTAQGRDIKLAKERIEGYRAFANKLWNASRFALMNLSGYQERGEDPArLARTPADRWILARLQRAVNETVEALEAFRF 645
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 631 GEAGRQLYNFIWDDFCDWYIEMSKETLYGEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPHK------GTS 704
Cdd:PRK14900 646 NDAANAVYAFVWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQvgasawADS 725
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 705 LVVADYPvvQPEYDDEAASKGMEVLKELIRSVRNIRSEVNTP----LSKPITLLIKTNDPKIDQFLNEN-TSYIERFCNP 779
Cdd:PRK14900 726 VLAAEYP--RKGEADEAAEAAFRPVLGIIDAVRNIRGEMGIPwkvkLGAQAPVEIAVADPALRDLLQAGeLARVHRVAGV 803
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 780 E--ELTISSDVTAPDLAMSAVLTGAEIFLPLAGLINIEEEIQRLEKELAKWTGEVKRVQGKLSNERFVSNAPDDVVEAER 857
Cdd:PRK14900 804 EgsRLVVAAATAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDR 883
|
890 900
....*....|....*....|
gi 518552761 858 AKEKDYLEKQAAVNERIAQL 877
Cdd:PRK14900 884 ARAEELREKRGKLEAHRAML 903
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
4-881 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 921.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 4 EKNLSTKYNPQEVEAGRYQNWLDEDLFKPSGD----KKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDT 79
Cdd:PTZ00419 21 ISSMAASYDPKEVESGWYEWWEKSGFFKPAEDakslNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDET 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 80 LWLPGMDHAGIATQAKVEEKL-REQGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAV 158
Cdd:PTZ00419 101 LWVPGTDHAGIATQVVVEKKLmKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 159 RKVFVSLYEKELIYRGEYIINWDPQARTALSDIEVIHKEIE----------------GAFYHMSYELAD-GSGVVEIATT 221
Cdd:PTZ00419 181 KEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAYPLEDsGQEEIVVATT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 222 RPETMLGDTAIAVHPEDERYQALIGKKVILPLVN-KEIPIIADE-YVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNV 299
Cdd:PTZ00419 261 RIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINI 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 300 MNEDGTMNELAGKYQGMDRFAARKAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQE 379
Cdd:PTZ00419 341 FTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVR 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 380 TDDaVEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIPAWyhKETGEmyVGMEAPADSENWL----------------- 442
Cdd:PTZ00419 421 NGE-LKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAY--RVISK--GPETDPSDEEPWVvarseeealekakkkfg 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 443 ---------QDPDVLDTWFSSALWPFSTMGWPDEdNEDYQRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLI 513
Cdd:PTZ00419 496 lseedfeleQDEDVLDTWFSSGLFPFSTLGWPDQ-TDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFL 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 514 HGLIRDEQGRKMSKSLGNGIDPMEVIE-------------------------------------KYGADALRWFLSNGSA 556
Cdd:PTZ00419 575 HAMVRDSQGEKMSKSKGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFGLLAYTQ 654
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 557 PGQDVRFSYEKMDASWNFINKIWNASRFVIMNVEG------MTVEDIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEF 630
Cdd:PTZ00419 655 QGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKdfnlpnSTLFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDF 734
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 631 GEAGRQLYNFIWDDFCDWYIEMSKETL-YGEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIP---HKGTSLV 706
Cdd:PTZ00419 735 SEATQATYNFWLYELCDVYLELIKPRLsKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPnylRKSESIS 814
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 707 VADYPVVQPEYDDEAASKGMEVLKELIRSVRNIRSEVNTPLSKPITLLIKTNDPKIDQFLNENTSYIERFCNPEELTISS 786
Cdd:PTZ00419 815 IAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIELIESAENLISTLAKIGSVSVIP 894
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 787 DVTA-----PDLAMSAVLTGAEIFLPLAGLINIEEEIQRLEKELAKWTGEVKRVQGKLSNERFVSNAPDDVVEAERAKEK 861
Cdd:PTZ00419 895 PIEEeaevpKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRKLNDEKID 974
|
970 980
....*....|....*....|
gi 518552761 862 DYLEKQAAVNERIAQLKSIK 881
Cdd:PTZ00419 975 ELNEEIKQLEQAIEELKSLL 994
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
21-879 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 858.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 21 YQNWLDEDLFKPSGDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKVEEKL 100
Cdd:PLN02943 70 YNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKML 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 101 REQGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGEYIINW 180
Cdd:PLN02943 150 ASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNW 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 181 DPQARTALSDIEVIHKEIEGAFYHMSYELADGSG-VVEIATTRPETMLGDTAIAVHPEDERYQALIGKKVILPLV-NKEI 258
Cdd:PLN02943 230 SPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGSEdFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTyGRHV 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 259 PIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYqgmdRFAARKAIVADLKELGRLIKI 338
Cdd:PLN02943 310 PIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAGLY----WFEAREKLWSDLEETGLAVKK 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 339 ETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQEtDDAVEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIP 418
Cdd:PLN02943 386 EPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVE-NGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIP 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 419 AWY--HKETGEMYV-----------GMEAPADSENWLQDPDVLDTWFSSALWPFSTMGWPDEDNEDYQRYFPTSTLVTGY 485
Cdd:PLN02943 465 VWYivGKDCEEDYIvarsaeealekAREKYGKDVEIYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETGH 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 486 DIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSApGQDVRFSY 565
Cdd:PLN02943 545 DILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTA-GQDLNLST 623
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 566 EKMDASWNFINKIWNASRFVIMNVEGMT-------VEDIDLSGEKTVA-----DRWILTRLNETIAKVTDLFEQFEFGEA 633
Cdd:PLN02943 624 ERLTSNKAFTNKLWNAGKFVLQNLPSQSdtsawehILACKFDKEESLLslplpECWVVSKLHELIDSVTTSYDKYFFGDV 703
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 634 GRQLYNFIWDDFCDWYIEMSKETLYG-EDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPHKGTSLVVADYPV 712
Cdd:PLN02943 704 GREIYDFFWSDFADWYIEASKTRLYHsGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRKEALIVSPWPQ 783
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 713 VQPEYDDEAASKgMEVLKELIRSVRNIRSEVNTPLSKPITLLIKTNDPKIdQFLNENTSYIERFCNPEELTISSDVTAP- 791
Cdd:PLN02943 784 TSLPKDLKSIKR-FENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVI-EYISKEKEVLALLSRLDLQNVHFTDSPPg 861
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 792 --DLAMSAVLT-GAEIFLPLAGLINIEEEIQRLEKELAKWTGEVKRVQGKLSNERFVSNAPDDVVEAERAKEKDYLEKQA 868
Cdd:PLN02943 862 daNQSVHLVASeGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKIK 941
|
890
....*....|.
gi 518552761 869 AVNERIAQLKS 879
Cdd:PLN02943 942 LTKNRLAFLKS 952
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
19-564 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 748.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 19 GRYQNWLDEDLFKPS--GDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKV 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPEleKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 97 EEKL-REQGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGE 175
Cdd:pfam00133 81 EKKLgIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 176 YIINWDPQARTALSDIEVIHKEIEGAFYHMSYELADGSGV-VEIATTRPETMLGDTAIAVHPE----------------- 237
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGAsLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeall 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 238 --------------DERYQALIGKKVILPLVNKEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNED 303
Cdd:pfam00133 241 kslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 304 GTMNELAGKYQGMDRFAARKAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQETdda 383
Cdd:pfam00133 321 GTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEK--- 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 384 VEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIPAWYHKETGEMYVGME---------APADSENWL------------ 442
Cdd:pfam00133 398 VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGElfelvagrfEEEGSIKWLhreakdklgygk 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 443 ----QDPDVLDTWFSSALWPFSTMGWPDEDNEDYQRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIR 518
Cdd:pfam00133 478 gtleQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVR 557
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 518552761 519 DEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNgSAPGQDVRFS 564
Cdd:pfam00133 558 DEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 602
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
3-881 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 683.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 3 EEKNLST----KYNPQEVEAGRYQNWLDEDLFKPSGDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYD 78
Cdd:PLN02381 88 QKKRLSSqmakQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYN 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 79 TLWLPGMDHAGIATQAKVEEKL-REQGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEA 157
Cdd:PLN02381 168 ALWVPGVDHAGIATQVVVEKKLmRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKA 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 158 VRKVFVSLYEKELIYRGEYIINWDPQARTALSDIEVIHKEIE----------------GAFYHMSYELADGSGVVEIATT 221
Cdd:PLN02381 248 VTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKertllkvpgydkpvefGVLTSFAYPLEGGLGEIVVATT 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 222 RPETMLGDTAIAVHPEDERYQALIGKKVILPLVNKEIPIIAD-EYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVM 300
Cdd:PLN02381 328 RIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIF 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 301 NEDGTMNELAG-KYQGMDRFAARKAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIQNQE 379
Cdd:PLN02381 408 TDDGKINSNGGsEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAI 487
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 380 TDDA--VEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIPAWY-------HKETG-----------EMYVGMEA----P 435
Cdd:PLN02381 488 DGENkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtleddqLKELGsyndhwvvarnESDALLEAsqkfP 567
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 436 ADSENWLQDPDVLDTWFSSALWPFSTMGWPDeDNEDYQRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHG 515
Cdd:PLN02381 568 GKKFELSQDPDVLDTWFSSGLFPLSVLGWPD-DTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHP 646
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 516 LIRDEQGRKMSKSLGNGIDPMEVIE-------------------------------------KYGADALRWFLSNGSAPG 558
Cdd:PLN02381 647 MIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvvakegqkkdfpngiaECGTDALRFALVSYTAQS 726
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 559 QDVRFSYEKMDASWNFINKIWNASRFVIMNVEGMTVEDIDLSGEKTVAD-RWILTRLNETIAKVTDLFEQFEFGEAGRQL 637
Cdd:PLN02381 727 DKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFScKWILSVLNKAISKTVSSLDAYEFSDAASTV 806
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 638 YNFIWDDFCDWYIEMSKETLYGED---EVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPH-KGT----SLVVAD 709
Cdd:PLN02381 807 YSWWQYQFCDVFIEAIKPYFAGDNpefASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQpKDHtrkdSIMISE 886
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 710 YPVVQPEYDDEAASKGMEVLKELIRSVRNIRSEVntplskpitLLIKTND--PKIDQFLNENTSYIERFCNPEELTISS- 786
Cdd:PLN02381 887 YPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAEV---------LEKQKNErlPAFALCRNQEIAAIIKSHQLEILTLANl 957
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 787 ----------DVTAPDLAMSAVLTGAEIFLPLAGLINIEEEIQRLEKELakwtGEVKRVQGKLSNERFVS----NAPDDV 852
Cdd:PLN02381 958 sslkvllsenDAPPAGCAFENVNENLKVYLQAQGAVNAEAELEKLRNKM----DEIQKQQEKLEKKMNASgykeKVPANI 1033
|
970 980
....*....|....*....|....*....
gi 518552761 853 VEAERAKEKDYLEKQAAVNERIAQLKSIK 881
Cdd:PLN02381 1034 QEEDARKLTKLLQELEFFEKESKRLEAET 1062
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
4-799 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 676.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 4 EKNLSTKYNPQEVEAgRYQN-WLDEDLFKPSGDKKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWL 82
Cdd:PRK13208 3 MPELPKKYDPEELEE-KWQKiWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 83 PGMDHAGIATQAKVEEKLreqGVSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDglsEAVRKV- 161
Cdd:PRK13208 82 QGWDDNGLPTERKVEKYY---GIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISP---EYRRISq 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 162 --FVSLYEKELIYRGEYIINWDPQARTALSDIEVIHKEIEGAFYHMSYELADGsGVVEIATTRPETMLGDTAIAVHPEDE 239
Cdd:PRK13208 156 ksFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG-EEIEIATTRPELLPACVAVVVHPDDE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 240 RYQALIGKKVILPLVNKEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYQGMDRF 319
Cdd:PRK13208 235 RYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 320 AARKAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPLAEKAIqnqETDDAVEFFPPRFNQTFLRWM 399
Cdd:PRK13208 315 EARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELL---ERGKEINWYPEHMRVRLENWI 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 400 ENVH-DWVISRQLWWGHQIPAWYHKETGEMYVGMEA--PAD---------------SENWLQDPDVLDTWFSSALWPFST 461
Cdd:PRK13208 392 EGLNwDWCISRQRYFGTPIPVWYCKDCGHPILPDEEdlPVDptkdeppgykcpqcgSPGFEGETDVMDTWATSSITPLIV 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 462 MGWPdEDNEDYQRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEK 541
Cdd:PRK13208 472 TGWE-RDEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEK 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 542 YGADALRWFLSNGSaPGQDVRFSYEKMDASWNFINKIWNASRFViMNVEGMTVEDIDlsGEKTVADRWILTRLNETIAKV 621
Cdd:PRK13208 551 YGADAVRYWAASAR-LGSDTPFDEKQVKIGRRLLTKLWNASRFV-LHFSADPEPDKA--EVLEPLDRWILAKLAKVVEKA 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 622 TDLFEQFEFGEAGRQLYNFIWDDFCDWYIEMSKETLYGEDEVAKQTN-RSILVHTLDQILRLLHPIMPFVTEEIWQHIph 700
Cdd:PRK13208 627 TEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGEDEEEEQKSaRYTLYTVLDTLLRLLAPFLPFITEEVWSWL-- 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 701 KGTSLVVADYPVVQPEYDDEAASKGMEVLKELIRSVRNIRSEVNTPLSKPITLLIKTNDPKIDQfLNENTSYIERFCNPE 780
Cdd:PRK13208 705 YGGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPADLEL-LEAAEEDLKAAGNIE 783
|
810
....*....|....*....
gi 518552761 781 ELTISSDvtAPDLAMSAVL 799
Cdd:PRK13208 784 ELELVEG--DPELEVEIIA 800
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
39-563 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 536.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 39 KPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKVEEKLREQGVSRYDLGREKFIDQ 118
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLGREEFLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 119 VWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGEYIINWDPQARTALSDIEVihkei 198
Cdd:cd00817 81 CWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 199 egafyhmsyeladgsgvveiattrpetmlgdtaiavhpederyqaligkkvilplvnkeipiiadeyvdmefgtgvvkit 278
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 279 pahdpndfevgnrhdlprvnvmnedgtmnelagkyqgmdrfaarkaivadlkelgrlikietmihnvghSERTGVVVEPR 358
Cdd:cd00817 156 ---------------------------------------------------------------------CSRSGDVIEPL 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 359 LSTQWFVKMAPLAEKAIQNQETDDaVEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIPAWYHKETGEMYVG------- 431
Cdd:cd00817 167 LKPQWFVKVKDLAKKALEAVKEGD-IKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAreedeai 245
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 432 ------MEAPADSENWLQDPDVLDTWFSSALWPFSTMGWPDEDnEDYQRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTER 505
Cdd:cd00817 246 dkaapeACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEET-KDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGK 324
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 518552761 506 RPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRF 563
Cdd:cd00817 325 LPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
10-806 |
5.94e-147 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 457.62 E-value: 5.94e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 10 KYNPQEVEAGRYQNWLDEDLFKPSGDKKA--KPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMD- 86
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEKSREARAgrPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDc 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 87 HaGIATQAKVEEKLreqGVSRYD---LGREKFIDQ----VWEWKEEYaghiREQWAKMGLSLDYSRERFTLDDGLSEAVR 159
Cdd:COG0060 95 H-GLPIELKVEKEL---GIKKKDiekVGIAEFREKcreyALKYVDEQ----REDFKRLGVWGDWDNPYLTMDPEYEESIW 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 160 KVFVSLYEKELIYRGEYIINWDPQARTALSDieviHkEIEgafYHM--------SYELADGSGVVE-------IATTRPE 224
Cdd:COG0060 167 WALKKLYEKGLLYKGLKPVPWCPRCGTALAE----A-EVE---YKDvtspsiyvKFPVKDEKALLLledaylvIWTTTPW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 225 TMLGDTAIAVHPE----------DERY---------------------------QALIGKKVILPL-----VNKEIPIIA 262
Cdd:COG0060 239 TLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFyyvvgYDRAHPVIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 263 DEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYQGMDRFAARKAIVADLKELGRLIKIETMI 342
Cdd:COG0060 319 GDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKIT 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 343 HNVGHSERTGvvvEP---RLSTQWFVKMAPLAEKAIQNQETddaVEFFPP----RFNQtflrWMENVHDWVISRQLWWGH 415
Cdd:COG0060 399 HSYPHCWRCK---TPliyRATPQWFISMDKLRDRALEAIEK---VNWIPEwgegRFGN----MLENRPDWCISRQRYWGV 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 416 QIPAWYHKETGEMYVGME--------------------------------APADSENWLQDPDVLDTWFSSALWPFSTMg 463
Cdd:COG0060 469 PIPIWVCEDCGELHRTEEvigsvaelleeegadawfeldlhrpfldetlkCPKCGGTMRRVPDVLDVWFDSGSMHFAVL- 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 464 wpdEDNEDYQryFP--------------------TSTLVTGydiiffwvsrmifqslefteRRPFENVLIHGLIRDEQGR 523
Cdd:COG0060 548 ---ENREELH--FPadfylegsdqtrgwfyssllTSTALFG--------------------RAPYKNVLTHGFVLDEDGR 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 524 KMSKSLGNGIDPMEVIEKYGADALRWFLSNgSAPGQDVRFSYEKMDASWNFINKIWNASRFVIMNVEGMTVEDIDLSGEK 603
Cdd:COG0060 603 KMSKSLGNVVDPQEVIDKYGADILRLWVAS-SDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYED 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 604 TVA-DRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIWDDFCDWYIEMSKETLY--GEDEVAKQTNRSILVHTLDQIL 680
Cdd:COG0060 682 LPElDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYteAADSLDRRAAQTTLYEVLETLV 761
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 681 RLLHPIMPFVTEEIWQHIPHKGTSLV-VADYPVVQPEYDDEAASKGMEVLKELIRSVR----NIRSE--VNTPLSKpitL 753
Cdd:COG0060 762 RLLAPILPFTAEEIWQNLPGEAEESVhLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEklIRQPLEA---A 838
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 518552761 754 LIKTNDPKIDQFLNENTSYIERFCNPEELTISSDVTAPDLAMSAVLTGAEIFL 806
Cdd:COG0060 839 VVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDLGKDALKALDVEGISV 891
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-563 |
2.70e-78 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 256.58 E-value: 2.70e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 40 PYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKVEEKLreqGVSRYDLGREKFIDQV 119
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKG---GRKKKTIWIEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 120 WEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGEYiinwdpqartalsdievihkeie 199
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTH----------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 200 gafyhmsyeladgsgvveiattrpetmlgdtaiavhpederyqaligkkvilplvnkeipiiadeyvdmefgtgVVKITP 279
Cdd:cd00668 135 --------------------------------------------------------------------------PVRITE 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 280 ahdpndfevgnrhdlprvnvmnedgtmnelagkyqgmdrfaarkaivadlkelgrlikietmihnvghsertgvvveprl 359
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 360 stQWFVKMAPLAEKAIQNQETDDaveFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIPawyhketgemyvgmeapadse 439
Cdd:cd00668 141 --QWFFDMPKFKEKLLKALRRGK---IVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP--------------------- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 440 nwlqdPDVLDTWFSSALWPFSTMGWPdEDNEDYQRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRD 519
Cdd:cd00668 195 -----EDVFDVWFDSGIGPLGSLGYP-EEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLD 268
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 518552761 520 EQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRF 563
Cdd:cd00668 269 EGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
24-747 |
2.55e-69 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 248.53 E-value: 2.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 24 WLDEDLFKPSGDKK-AKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKVEEKLRE 102
Cdd:PLN02843 16 WEENQVYKRVSDRNnGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSLDQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 103 QgvSRYDLGREKFIDQVWEWKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGEYIINWDP 182
Cdd:PLN02843 96 E--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 183 QARTALSDIEV------IHKEIEGAF---------YHMSYELADGSGVVeIATTRPETMLGDTAIAVHP----------- 236
Cdd:PLN02843 174 SSRTALAEAELeypeghVSKSIYVAFpvvspsetsPEELEEFLPGLSLA-IWTTTPWTMPANAAVAVNDklqysvvevqs 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 237 --EDERY-----------------------------------------------QALIGKKVILPLVNKEIPIIAD-EYV 266
Cdd:PLN02843 253 fsEDESTsggnkkkrpgnvlkeqqklflivatdlvpaleakwgvklvvlktfpgSDLEGCRYIHPLYNRESPVVIGgDYI 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 267 DMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNVMNEDGTMNELAGKYQGMDRFAA-RKAIVADLKELGRLIKIETMIHNV 345
Cdd:PLN02843 333 TTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLGEgNAAVVEALDEAGSLLMEEAYGHKY 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 346 GHSERTGVVVEPRLSTQWFVKMAPLAEKAIqnqETDDAVEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIPAWYHKET 425
Cdd:PLN02843 413 PYDWRTKKPTIFRATEQWFASVEGFRQAAL---DAIDKVKWIPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHVET 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 426 GE-------------------------MYVGMEAP----ADSENWLQDPDVLDTWFSSAlwpfstMGWPDEDNEDYQRYF 476
Cdd:PLN02843 490 KEplmneetiahvksivaqkgsdawwyMDVEDLLPekyrDKASDYEKGTDTMDVWFDSG------SSWAGVLGSREGLSY 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 477 PTSTLVTGYDIIFFWVSRMIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIE---------KYGADAL 547
Cdd:PLN02843 564 PADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVL 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 548 RWFLSNGSAPGqDVRFSYEKMDASWNFINKIWNASRFVIMNVEGMTVEDI----DLSGektvADRWILTRLNETIAKVTD 623
Cdd:PLN02843 644 RLWVASVDYTG-DVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPDNAvpyeDLPS----IDKYALFQLENVVNEIEE 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 624 LFEQFEFGEAGRQLYNFIWDDFCDWYIEMSKETLY--GEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPHK 701
Cdd:PLN02843 719 SYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYvgGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQ 798
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 518552761 702 GT-----SLVVADYPVVQPEY----DDEAAskgmevlkeLIRSVRNIRSEVNTPL 747
Cdd:PLN02843 799 EDgsaaeSVFEAGWPTPNEEWlsfpAEDVD---------FWSLLLEVRDEVNKVL 844
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
563-698 |
3.80e-65 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 214.34 E-value: 3.80e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 563 FSYEKMDASWNFINKIWNASRFVIMNVEGmTVEDIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIW 642
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLED-DDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFW 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 518552761 643 DDFCDWYIEMSKETLYGEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHI 698
Cdd:cd07962 80 NDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
8-720 |
6.73e-64 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 230.71 E-value: 6.73e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 8 STKYNPQEVEAgRYQN-WLDEDLFKPSGDKKAKPYSIVI--PPPnvTGKLHLGHAWDTTLQDMLIRQKRMQGYDTL---- 80
Cdd:COG0495 2 QERYNPKEIEK-KWQKyWEENGTFKADEDSSKPKYYVLDmfPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhpmg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 81 W----LPgmdhagiATQAKVEEKL--REqgvsrydlgrekfidqvweWKEEYAGHIREQWAKMGLSLDYSRE-------- 146
Cdd:COG0495 79 WdafgLP-------AENAAIKNGVhpAE-------------------WTYENIANMRRQLKRLGLSYDWSREiatcdpey 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 147 -RFTlddglseavRKVFVSLYEKELIYRGEYIINWDPQARTAL------------SDIEVIHKEI--------------- 198
Cdd:COG0495 133 yKWT---------QWIFLQLYEKGLAYRKEAPVNWCPVDQTVLaneqvidgrcwrCGAPVEKKELpqwflkitdyadell 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 199 ------------------------EGAfyHMSYELADGSGVVEIATTRPETMLGDTAIAV---HP------EDERYQAL- 244
Cdd:COG0495 204 ddldkldgwpekvktmqrnwigrsEGA--EVDFPVEGSDEKITVFTTRPDTLFGATFMVLapeHPlvkelaTPEQNAAVa 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 245 -------------------------IGKKVILPLVNKEIPI-IADeYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVN 298
Cdd:COG0495 282 afieeakkkseiertsetkektgvfTGLYAINPLTGEKIPIwIAD-YVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQ 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 299 VMN---------------EDGTM-NelAGKYQGMDRFAARKAIVADLKELGrlikietmihnvghsertgvvveprlstq 362
Cdd:COG0495 361 VIApedgddpdileeaytGDGVLiN--SGEFDGLDSEEAKEAIIEWLEEKG----------------------------- 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 363 wfvkmapLAEKAIqnqetddaveffpprfnqTF-LRwmenvhDWVISRQLWWGHQIPAwYHKETG--------------- 426
Cdd:COG0495 410 -------LGKRKV------------------NYrLR------DWLISRQRYWGEPIPI-IHCEDCgvvpvpedqlpvelp 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 427 ---EMYVGMEAP-ADSENWLQ------------DPDVLDTWF-SSalWPFstMGWPDEDNED------------------ 471
Cdd:COG0495 458 edvDFDPTGGSPlARAPEWVNvtcpkcggparrETDTMDTFVdSS--WYY--LRYTDPHNDEapfdpeaanywlpvdqyi 533
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 472 -----------YQRYFptsTLV---TGYdiiffwvsrmifqsLEFTErrPFENVLIHGLIRD--EQGR------KMSKSL 529
Cdd:COG0495 534 ggiehailhllYARFF---TKVlrdLGL--------------VSFDE--PFKRLLTQGMVLEvgKDGVviggieKMSKSK 594
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 530 GNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWnasRFVIMNVEGMTVEDIDLSGEktvaDRW 609
Cdd:COG0495 595 GNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVW---RLVVDEAEALKLDVADLSEA----DKE 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 610 ILTRLNETIAKVTDLFEQFEFGEAGRQLYnfiwddfcdwyiEMSKEtLYGEDEVAKQtNRSILVHTLDQILRLLHPIMPF 689
Cdd:COG0495 668 LRRALHKTIKKVTEDIERLRFNTAIAALM------------ELVNA-LYKAKDSGEA-DRAVLREALETLVLLLAPFAPH 733
|
890 900 910
....*....|....*....|....*....|...
gi 518552761 690 VTEEIWQHIPHKGtSLVVADYPVVQPEY--DDE 720
Cdd:COG0495 734 IAEELWERLGHEG-SVADAPWPEADEAAlvEDE 765
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
47-860 |
6.98e-64 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 233.85 E-value: 6.98e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 47 PPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKVEEKL----REQ----GVSRYDlgrEKFIDQ 118
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLgikrRDDvlkmGIDKYN---EECRSI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 119 VWEWKEEYAGHIreqwAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGEYIINWDPQARTALSDIEV--IHK 196
Cdd:PLN02882 123 VTRYSKEWEKTV----TRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 197 EIEGAFYHMSYEL---ADGSGVVEIATTrPETMLGDTAIAVHPE------------------------------------ 237
Cdd:PLN02882 199 DVSDPAVMVSFPIvgdPDNASFVAWTTT-PWTLPSNLALCVNPNftyvkvrnkytgkvyivaesrlsalptakpkskkgs 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 238 -----DERYQ--------ALIGKKVIlPLVN-------KEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRH----- 292
Cdd:PLN02882 278 kpenaAEGYEvlakvpgsSLVGKKYE-PLFDyfsefsdTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANgiiek 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 293 --DLPrvNVMNEDGTMNELAGKYQGMDRFAARKAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVKMAPL 370
Cdd:PLN02882 357 ggNLP--VPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEI 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 371 AEKAIQNQETDDAVeffpPRF--NQTFLRWMENVHDWVISRQLWWGHQIPAWYhKETGEMYVGMEAPADSE--------- 439
Cdd:PLN02882 435 KDRLLENNKQTYWV----PDYvkEKRFHNWLENARDWAVSRSRFWGTPLPIWI-SDDGEEVVVIGSIAELEklsgvkvtd 509
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 440 ------NWLQDP--------------DVLDTWFSSALWPFSTMGWPDEDNEDYQRYFPTSTLVTGYDIIFFWVSRMIFQS 499
Cdd:PLN02882 510 lhrhfiDHITIPssrgpefgvlrrvdDVFDCWFESGSMPYAYIHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLS 589
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 500 LEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNgsAP---GQDVRFSYEKMDASWNFIN 576
Cdd:PLN02882 590 TALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN--SPvvrAEPLRFKEEGVFGVVKDVF 667
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 577 KIW-NASRFVIMNVEGMTVEDID---------LSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwDDFC 646
Cdd:PLN02882 668 LPWyNAYRFLVQNAKRLEVEGGApfvpldlakLQNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFI-DNLT 746
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 647 DWYIEMSKETLYGED-EVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHI----PHKGTSLVVADYPVVQPEYDDEA 721
Cdd:PLN02882 747 NIYVRFNRKRLKGRTgEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrkvlPGSEESIHYCSFPQVDEGELDER 826
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 722 ASKGMEVLKELIRSVRNIRSEVNTPLSKPITLLIKTnDPKIDqFLNENTSYIERFCNpEELTISSDVTAPDLAMSAVLTG 801
Cdd:PLN02882 827 IEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVV-HPDAE-FLDDITGKLKEYVL-EELNVRSLVPCNDPLKYASLRA 903
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 518552761 802 aeiflplagliniEEEIQRLEKELAKWTGEVKRVQGKLSnerfvsnaPDDVVEAERAKE 860
Cdd:PLN02882 904 -------------EPNFSVLGKRLGKSMGLVAKEVKAMS--------QDDILEFEKAGE 941
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-867 |
1.25e-57 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 213.19 E-value: 1.25e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 54 LHLGHAWDTTLQDMLIRQKRMQGYDTLWlPGMDHA------GIATQ-----AKVEEKLRE-QGVSRYDLgrEKFIDQvWE 121
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PMAFHVtgtpilGIAERiargdPETIELYKSlYGIPEEEL--EKFKDP-EY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 122 WKEEYAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGEYIINWDPQARTALSDieviH--KEIE 199
Cdd:PRK12300 77 IVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGD----HdlLDGE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 200 GA---------FYHmsyelaDGSGVVEIATTRPETMLGDTAIAVHPEDE---------------------RYQ------- 242
Cdd:PRK12300 153 EPeiveytlikFEE------SEDLILPAATLRPETIFGVTNLWVNPDATyvkaevdgekwivskeaaeklSFQdrdveii 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 243 ------ALIGKKVILPLVNKEIPIIADEYVDMEFGTGVVKITPAHDPNDF----------------------EVGNRHDL 294
Cdd:PRK12300 227 eeikgsELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrdlkknkelldviepipliEVEGYGEF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 295 P------RVNVMNED------------------GTMNELAGKYQGMDRFAARKAIVADLKELGRLIKI-ETMIHNV---- 345
Cdd:PRK12300 307 PakevveKLGIKSQEdpeleeatkevyraefhkGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMyEFSNRPVycrc 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 346 GhserTGVVVEpRLSTQWFVKMA-----PLAEKAIqnqetdDAVEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIP-- 418
Cdd:PRK12300 387 G----TECVVK-VVKDQWFIDYSdpewkELAHKAL------DNMEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPwd 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 419 ---------------AWY---HK-ETGEMyvgmeapaDSENWlqDPDVLDTWF---SSALWPFSTMGWPDEDNEDYQRYF 476
Cdd:PRK12300 456 eewiieslsdstiymAYYtiaHKiREYGI--------KPEQL--TPEFFDYVFlgkGDPEEVSKKTGIPKEILEEMREEF 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 477 ----PTSTLVTGYDII-----FFwvsrmIFQSLE-FTERRPFENVLIHGLIRDEqGRKMSKSLGNGIDPMEVIEKYGADA 546
Cdd:PRK12300 526 lywyPVDWRHSGKDLIpnhltFF-----IFNHVAiFPEEKWPRGIVVNGFVLLE-GKKMSKSKGNVIPLRKAIEEYGADV 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 547 LRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWNasrfVIMNVEGMTVEDidlsgEKTVADRWILTRLNETIAKVTDLFE 626
Cdd:PRK12300 600 VRLYLTSSAELLQDADWREKEVESVRRQLERFYE----LAKELIEIGGEE-----ELRFIDKWLLSRLNRIIKETTEAME 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 627 QFEFGEAGRQLYNFIWDDFcDWYIEMSKEtlygedevakqTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPHKGTsLV 706
Cdd:PRK12300 671 SFQTRDAVQEAFYELLNDL-RWYLRRVGE-----------ANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGF-VS 737
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 707 VADYPVVQPEYDDEAASKGMEVLKELIRSVRNIRSEVNTplskpitlliktndpkidqflnentsyierfcNPEELTIss 786
Cdd:PRK12300 738 LEKWPEPDESKIDEEAELAEEYVKRLIEDIREILKVAKI--------------------------------KPKKVYI-- 783
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 787 dVTAPDLAMSAVLTGAEIFLPLAGLINI--EEEIQRLEKELAKWTGEVKRVQGKLSNERF-VSNAPDDVVEAERaKEKDY 863
Cdd:PRK12300 784 -YVAPDWKYEVLEIAAENGDVKEAIKELmkDEELRKHGKEVAKLAQKIVKEVLKLDKEVRkLILKNIDEEEVLE-EAKDF 861
|
....
gi 518552761 864 LEKQ 867
Cdd:PRK12300 862 LEKE 865
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
47-563 |
3.29e-55 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 194.37 E-value: 3.29e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 47 PPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKVEEKLREQGVS-RYDLGREKFIDQVWEWKEE 125
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKdIEKMGIAEFNAKCREFALR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 126 YAGHIREQWAKMGLSLDYSRERFTLDDGLSEAVRKVFVSLYEKELIYRGEYIINWdpqartalsdievihkeiegafyhm 205
Cdd:cd00818 89 YVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW------------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 206 syeladgsgvveiattrpetmlgdtaiavhpederyqaligkkvilplvnkeiPIIadeyvdmefgtgvvkitpahdpnd 285
Cdd:cd00818 144 -----------------------------------------------------PLI------------------------ 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 286 fevgnrhdlprvnvmnedgtmnelagkYqgmdrfaarkaivadlkelgrlikietmihnvghsertgvvvepRLSTQWFV 365
Cdd:cd00818 147 ---------------------------Y--------------------------------------------RATPQWFI 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 366 KMAPLAEKAIQNQETddaVEFFPPRFNQTFLRWMENVHDWVISRQLWWGHQIPAWYHKETGEMYVGMEapadsenwlqdP 445
Cdd:cd00818 156 RVTKIKDRLLEANDK---VNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLVRRV-----------P 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 446 DVLDTWFSSALWPFSTMGWPdEDNEDYQRYFPTSTLVTGYDIIFFWvsrmiFQSLEFT-----ERRPFENVLIHGLIRDE 520
Cdd:cd00818 222 DVLDVWFDSGSMPYAQLHYP-FENEDFEELFPADFILEGSDQTRGW-----FYSLLLLstalfGKAPYKNVIVHGFVLDE 295
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 518552761 521 QGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRF 563
Cdd:cd00818 296 DGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
607-755 |
2.00e-46 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 162.57 E-value: 2.00e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 607 DRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIWDDFCDWYIEMSKETLYGEDEvaKQTNRSILVHTLDQILRLLHPI 686
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEP--DSRAQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518552761 687 MPFVTEEIWQHIphkgtSLVVADYPvVQPEYDDEAASKGMEVLKELIRSVRNIRSEVNTPLSKPITLLI 755
Cdd:pfam08264 79 MPFITEELWQKE-----SIHLAPWP-EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
12-827 |
3.56e-44 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 173.61 E-value: 3.56e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 12 NPQEVEAGR--YQNWLDEDLFKPSGD--KKAKPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDH 87
Cdd:PTZ00427 71 NPNIVEEEEkvLKYWKSIDAFNTSNKlaKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDC 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 88 AGIATQAKVE--------EKLREQGVSRYDlgrEKFIDQVWEWKEEYAGHIReqwaKMGLSLDYSRERFTLDDGLSEAVR 159
Cdd:PTZ00427 151 HGLPIEYEIEkenninkkEDILKMGIDVYN---EKCRGIVLKYSNEWVKTVE----RIGRWIDFKNDYKTMDKTFMESVW 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 160 KVFVSLYEKELIYRGEYIINWDPQARTALSDIE------------VI--------------------------------- 194
Cdd:PTZ00427 224 WVFSELYKNNYVYKSFKVMPYSCKCNTPISNFElnlnykdtpdpsIIisfvlcsdfpkveeecnieedkqllgekysvly 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 195 -----------HKEIEGAFYHMSYEladgsgvVEIATTRPETMLGDTAIAV----------HPEDERyqALIGKKVILPL 253
Cdd:PTZ00427 304 nnkrensnngnNNSTNNVCYAQHSE-------ILAWTTTPWTLPSNLALCVnehftylrihHVKSNR--VVIVGECRLEW 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 254 VNKEIP-----------------------------------------IIADEYVDMEFGTGVVKITPAHDPNDFEVGNRH 292
Cdd:PTZ00427 375 IMKELKwnvedlkivnrfkgkelkglrykplftnfyekynfkeraykILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKN 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 293 DL--PRVNV----MNEDGTMNELAGKYQGMDRFAARKAIVADLKELGRLIKIETMIHNVGHSERTGVVVEPRLSTQWFVK 366
Cdd:PTZ00427 455 GVidPEKNIfidpLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIR 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 367 MAPLAEKAIQNQETddaVEFFPPRFNQT-FLRWMENVHDWVISRQLWWGHQIPAWYhKETGEMYVGMEAPADSENW---- 441
Cdd:PTZ00427 535 VSNSTNELVKNNET---TYWIPAHIKEKkFHNWIKDAKDWCISRNRYWGTPIPIWA-DEKMETVICVESIKHLEELsgvk 610
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 442 -LQD-------------------------PDVLDTWFSSALWPFSTMGWP-DEDNEDYQRYFPTSTLVTGYDIIFFWVSR 494
Cdd:PTZ00427 611 nINDlhrhfidhieiknpkgktypklkriPEVFDCWFESGSMPYAKVHYPfSTEKEDFHKIFPADFIAEGLDQTRGWFYT 690
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 495 MIFQSLEFTERRPFENVLIHGLIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSA-PGQDVRFSYEKMDA--- 570
Cdd:PTZ00427 691 LLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAvRAENLKFQEKGVNEvvk 770
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 571 --------SWNFINKiwNASRFVIMNVEGMTVEDIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIw 642
Cdd:PTZ00427 771 sfilpfyhSFRFFSQ--EVTRYECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI- 847
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 643 DDFCDWYIEMSKETL---YGEDEVAKQTNrsILVHTLDQILRLLHPIMPFVTEEIWQ---HIPHKGTSLVVADYPVVQ-- 714
Cdd:PTZ00427 848 ENLTNWYIRLNRDRMrgsLGEENCLQSLC--TTYRTLHLFTVLMAPFTPFITEYIYQqlrRVKSTNEHNENNETGNTKeg 925
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 715 ----------------PEYDDEAASKG-----MEVLKELIRSVRNIRSEVNTPLSKP---ITLLIKTND--PKIDQFLNe 768
Cdd:PTZ00427 926 dlnrgvihksvhfimlPQVDEKYIIDYeiielIEKMKDVILLGRVLRERRKVASKKPlksITILHPNESyfKNFDQISN- 1004
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 769 ntsYIERFCNPEELTISSDVTAPDLamSAVLTGAEIFLPLAG-LINIEEEIQRLEKELAK 827
Cdd:PTZ00427 1005 ---YIKEELNVLNVECSNDTSCLDF--SAIPNYKTLGVKLGYnLKKVQNKIKNMDSESIK 1059
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
45-696 |
1.09e-41 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 161.05 E-value: 1.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 45 IPPPNvtGKLHLGHAWdTTLQ-DMLIRQKRMQGYDTLWLPGMD-HagiatQAKVEEKLREQGVSRydlgrEKFIDqvwew 122
Cdd:COG0143 9 IPYAN--GPPHIGHLY-TYIPaDILARYQRLRGHDVLFVTGTDeH-----GTKIELAAEKEGITP-----QELVD----- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 123 keEYAGHIREQWAKMGLSLD-YSRerfTLDDGLSEAVRKVFVSLYEKELIYRGEYiinwdpqartalsdievihkeiEGA 201
Cdd:COG0143 71 --RIHAEFKELFEKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEY----------------------EGW 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 202 FyhmsyeladgsgvveiattrpetmlgDtaiavhPEDERYqaligkkviLPlvnkeipiiaDEYVDmefGTGvvkitpah 281
Cdd:COG0143 124 Y--------------------------C------PECERF---------LP----------DRYVE---GTC-------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 282 dpndfevgnrhdlPRVNVMNEDGTMNELAGKyqgmdrfaarkaivadLKELGRLIKIETMIHnvghsertGVVVEPRLST 361
Cdd:COG0143 142 -------------PKCGAEDAYGDQCENCGA----------------TLEPTELINPRSAIS--------GAPPELREEE 184
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 362 QWFVKMAPLAEKAIQNQETDDAVEffPPRFNQTfLRWMEN-VHDWVISRQLWWGHQIPaWYHKETgeMYVGMEAP----A 436
Cdd:COG0143 185 HYFFRLSKYQDRLLEWIEENPDIQ--PEVRNEV-LSWLKEgLQDLSISRDFDWGIPVP-GDPGKV--FYVWFDALigyiS 258
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 437 DSENWLQDPDVLDTWfssalWPFstmgWPDEDNEDYQryfptstlVTGYDIIFF----WVSrMifqsLEFTERRPFENVL 512
Cdd:COG0143 259 ATKGYADDRGLPEDF-----EKY----WPAPDTELVH--------FIGKDIIRFhaiiWPA-M----LMAAGLPLPKKVF 316
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 513 IHGLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWNF--INKIWN-ASR---FVI 586
Cdd:COG0143 317 AHGFLTVE-GEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDFVARVNSdlANDLGNlASRtlsMIH 395
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 587 MNVEGMtvedIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwdDFCDWYIemsketlygeDE---- 662
Cdd:COG0143 396 KYFDGK----VPEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALA--RAANKYI----------DEtapw 459
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 518552761 663 -VAKQTNR----SILVHTLdQILR----LLHPIMPFVTEEIWQ 696
Cdd:COG0143 460 kLAKDEDPerlaTVLYTLL-EALRilaiLLKPFLPETAEKILE 501
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
39-696 |
1.03e-33 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 136.55 E-value: 1.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 39 KPYSIVIPPPNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMD-HagiatQAKVEEKLREQGVSRYDLGREkfid 117
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeH-----GQKIQRKAEEAGISPQELADR---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 118 qvwewkeeYAGHIREQWAKMGLSLDysreRF--TLDDGLSEAVRKVFVSLYEKELIYRGEYiinwdpqartalsdiEVIH 195
Cdd:PRK11893 72 --------NSAAFKRLWEALNISYD----DFirTTDPRHKEAVQEIFQRLLANGDIYLGKY---------------EGWY 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 196 KEIEGAFYhmsyeladgsgvveiattRPETMLgdtaiavhpEDERYQALIGKKVilplvnkeipiiadEYVDmefgtgvv 275
Cdd:PRK11893 125 CVRCEEFY------------------TESELI---------EDGYRCPPTGAPV--------------EWVE-------- 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 276 kitpahdpndfevgnrhdlprvnvmnedgtmnelagkyqgmdrfaarkaivadlkelgrlikietmihnvghsertgvvv 355
Cdd:PRK11893 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 356 EPRlstqWFVKM---APLAEKAIQNQEtddavEFFPP--RFN--QTFLRwmENVHDWVISRQ-LWWGHQIPaWYHKETge 427
Cdd:PRK11893 156 EES----YFFRLskyQDKLLELYEANP-----DFIQPasRRNevISFVK--SGLKDLSISRTnFDWGIPVP-GDPKHV-- 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 428 MYVgmeapadsenwlqdpdvldtWFSsALWPF-STMGWPDEDN---EDYQRYFPTSTLVTGYDIIFF----WVsrmIF-Q 498
Cdd:PRK11893 222 IYV--------------------WFD-ALTNYlTALGYPDDEEllaELFNKYWPADVHLIGKDILRFhavyWP---AFlM 277
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 499 SLEFterRPFENVLIHGLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWN--FIN 576
Cdd:PRK11893 278 AAGL---PLPKRVFAHGFLTLD-GEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINRINadLAN 353
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 577 KIWN-ASRfvimnVEGMTVED----IDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwdDFCDWYIE 651
Cdd:PRK11893 354 DLGNlAQR-----TLSMIAKNfdgkVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYID 426
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 518552761 652 MSKE-TLYGEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQ 696
Cdd:PRK11893 427 EQAPwSLAKTDPERLATVLYTLLEVLRGIAVLLQPVMPELAAKILD 472
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
2-717 |
1.73e-32 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 136.11 E-value: 1.73e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 2 TEEKNLSTKYNPQEVEAGRYQNWLDEDLFK-PSGDKKAKPYSIVI---PPPNVTGkLHLGHAWDTTLQDMLIRQKRMQGY 77
Cdd:PLN02563 71 KTTPAAKRAYPFHEIEPKWQRYWEENRTFRtPDDVDTSKPKFYVLdmfPYPSGAG-LHVGHPEGYTATDILARYKRMQGY 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 78 DTLWLPGMDHAGI-ATQAKVEEKLREQGVSRYDLGRekfidqvwewkeeyaghIREQWAKMGLSLDYSRERFTLDDGLSE 156
Cdd:PLN02563 150 NVLHPMGWDAFGLpAEQYAIETGTHPKITTLKNIAR-----------------FRSQLKSLGFSYDWDREISTTEPEYYK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 157 AVRKVFVSLYEKELIYRGEYIINWDPQARTALSDIEVI--------HKEI------------------------------ 198
Cdd:PLN02563 213 WTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVdglserggHPVIrkpmrqwmlkitayadrlledlddldwpes 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 199 ------------EGAfyHMSYELADGSGV-----VEIATTRPETMLGDTAIAVHPED---------------ERYQALIG 246
Cdd:PLN02563 293 ikemqrnwigrsEGA--ELDFSVLDGEGKerdekITVYTTRPDTLFGATYLVVAPEHpllsslttaeqkeavEEYVDAAS 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 247 KKVIL--------------------PLVNKEIPIIADEYVDMEFGTGVVKITPAHDPNDFEVGNRHDLP-RVNVMNEDGT 305
Cdd:PLN02563 371 RKSDLertelqkektgvftgsyainPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPiKWVVKPADGN 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 306 MNELAGKYQGmdrfaarkaivadlkeLGRLIkietmihnvgHSERTGVVVEpRLSTqwfvkmAPLAEKAIQNQETDDAVE 385
Cdd:PLN02563 451 EDDAEKAYTG----------------EGVIV----------NSSSSGLDIN-GLSS------KEAAKKVIEWLEETGNGK 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 386 ffpPRFNQTfLRwmenvhDWVISRQLWWGHQIPAWYHKETGEMYVGMEA-------------PADS--------ENWLQD 444
Cdd:PLN02563 498 ---KKVNYK-LR------DWLFARQRYWGEPIPVVFLEDSGEPVPVPESdlpltlpelddftPTGTgepplakaVSWVNT 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 445 PDVLD-TWFSSALwpfSTM-GW------------PDEDNE----DYQRYF-PTSTLVTG------------------YDI 487
Cdd:PLN02563 568 VDPSSgKPARRET---NTMpQWagscwyylrfmdPKNSNAlvdkEKEKYWmPVDLYVGGaehavlhllyarfwhkvlYDI 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 488 IFfwVSR-----------MIFQSLEFT-----------------------ERRPFENVLIHG----LIRDEQGR------ 523
Cdd:PLN02563 645 GV--VSTkepfqclvnqgMILGEVEYTafkdsdgeyvsadtadrlgelqqEKIPEEKVIKSGdsfvLKDDPSIRliarah 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 524 KMSKSLGNGIDPMEVIEKYGADALR---WFLsngsAPGQDVR-FSYEKMDASWNFINKIWNAsrFVIMNVEGMTVEDIDL 599
Cdd:PLN02563 723 KMSKSRGNVVNPDDVVSEYGADSLRlyeMFM----GPLRDSKtWSTSGVEGVHRFLGRTWRL--VVGAPLPDGSFRDGTV 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 600 SGEKTvADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwddfcdwyiemskETLYGEDEVAKQtnrsilvhTLDQI 679
Cdd:PLN02563 797 VTDEE-PSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFT-------------NAAYKWDKVPRE--------AIEPF 854
|
890 900 910
....*....|....*....|....*....|....*...
gi 518552761 680 LRLLHPIMPFVTEEIWQHIPHKGtSLVVADYPVVQPEY 717
Cdd:PLN02563 855 VLLLSPYAPHLAEELWFRLGHSN-SLAYEPWPEANPSY 891
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
577-744 |
2.31e-28 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 112.23 E-value: 2.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 577 KIWNASRFVIMNVEGMTVEDIDLSGEK-TVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIWDDFCDWYIEMSKE 655
Cdd:cd07960 15 KIRNTFRFLLGNLNDFDPAKDAVPYEElLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDIIKD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 656 TLYGEDEVAKQtNRSI---LVHTLDQILRLLHPIMPFVTEEIWQHIPH--KGTSLVVADYPVVQPEYDDEAaskgmevLK 730
Cdd:cd07960 95 RLYCDAKDSLE-RRSAqtvLYHILDALLKLLAPILPFTAEEVWEHLPGekKEESVFLEDWPELPEEWKDEE-------LE 166
|
170
....*....|....
gi 518552761 731 ELIRSVRNIRSEVN 744
Cdd:cd07960 167 EKWEKLLALRDEVN 180
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
573-737 |
1.50e-26 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 107.25 E-value: 1.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 573 NFINKIWNASRFVI--MNVEGMTVEDIDLSGEKT-VADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwDDFCDWY 649
Cdd:cd07961 12 KVLLPLWNAYRFFVtyANLDGFDPGKDDDAVASLnVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI-DELTNWY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 650 IEMSKETLYGEDEVA-KQTNRSILVHTLDQILRLLHPIMPFVTEEIWQH----IPHKGTSLVVADYPVVQPEYDDEAASK 724
Cdd:cd07961 91 IRRNRKRFWGEEGDDdKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNlrreLGDAPESVHLLDWPEVDESLIDEELEE 170
|
170
....*....|...
gi 518552761 725 GMEVLKELIRSVR 737
Cdd:cd07961 171 AMELVREIVELGR 183
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
813-878 |
3.05e-26 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 102.35 E-value: 3.05e-26
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518552761 813 NIEEEIQRLEKELAKWTGEVKRVQGKLSNERFVSNAPDDVVEAERAKEKDYLEKQAAVNERIAQLK 878
Cdd:pfam10458 1 DVEKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKLG 66
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
48-578 |
2.57e-25 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 108.92 E-value: 2.57e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 48 PNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIATQAKVEEklreQGVSRydlgrEKFIDQVWEwkeeya 127
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK----EGITP-----EELVDRYHE------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 128 gHIREQWAKMGLSLD-YSRerfTLDDGLSEAVRKVFVSLYEKELIYRGEYIINWDPQARTALSDievihKEIEGAFYHMS 206
Cdd:pfam09334 73 -IHREDFKKFNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPD-----RYVEGTCPHCG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 207 YELADGSGVVEIATTrpetmlgdtaiaVHPEDeryqaLIGKKVIlplVNKEIPIIADEyvdmefgtgvvkitpahdpndf 286
Cdd:pfam09334 144 SEDARGDQCENCGRH------------LEPTE-----LINPKCV---ICGTTPEVKET---------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 287 evgnRH---DLPrvnvmnedgtmnelagKYQGMdrfaarkaivadLKElgrlikietmihnvghsertgvvveprlstqW 363
Cdd:pfam09334 182 ----EHyffDLS----------------KFQDK------------LRE-------------------------------W 198
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 364 FVKMAPLAekaiqnqetddaveffPPRFNQTFLRWMEN-VHDWVISRQLWWGHQIPAwYHKETgeMYVGMEAP----ADS 438
Cdd:pfam09334 199 IEENNPEW----------------PENVKNMVLEWLKEgLKDRAISRDLDWGIPVPG-AEGKV--FYVWLDAPigyiSAT 259
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 439 ENWLQDPDVLDTWfssalwpfstmgWPDEDN-EDYQryfptstlVTGYDIIFF----WVSRMIFQSLefterRPFENVLI 513
Cdd:pfam09334 260 KELSGNEEKWKEW------------WPNDPDtELVH--------FIGKDIIYFhtifWPAMLLGAGY-----RLPTTVFA 314
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518552761 514 HGLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRFSYEKmdaswnFINKI 578
Cdd:pfam09334 315 HGYLTYE-GGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWED------FVERV 372
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
50-698 |
7.79e-25 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 110.66 E-value: 7.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 50 VTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGiatQaKVEEKLREQGVSrydlgrEKfidqvwEWKEEYAGH 129
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---Q-KIQQAAEKAGKT------PQ------EYVDEISAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 130 IREQWAKMGLSLDYsrerF--TLDDGLSEAVRKVFVSLYEKELIYRGEYiinwdpqartalsdievihkeiEGaFYHMSY 207
Cdd:PRK12267 79 FKELWKKLDISYDK----FirTTDERHKKVVQKIFEKLYEQGDIYKGEY----------------------EG-WYCVSC 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 208 EladgsgvveiaTTRPETMLGDTAIAvhPEDeryqaliGKKVilplvnkeipiiadeyvdmefgtgvvkitpahdpndfe 287
Cdd:PRK12267 132 E-----------TFFTESQLVDGGKC--PDC-------GREV-------------------------------------- 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 288 vgnrhdlprvnvmnedgtmnelagkyqgmdrfaarkaivadlkelgRLIKIETmihnvghsertgvvveprlstqWFVKM 367
Cdd:PRK12267 154 ----------------------------------------------ELVKEES----------------------YFFRM 165
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 368 APLAEKAIQNQETDDavEFFPPRFNQT-----FLRwmENVHDWVISRQ-LWWGHQIPaWYHKETgeMYVgmeapadsenW 441
Cdd:PRK12267 166 SKYQDRLLEYYEENP--DFIQPESRKNeminnFIK--PGLEDLSISRTsFDWGIPVP-FDPKHV--VYV----------W 228
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 442 LqdpDVLdTWFSSALwpfstmGWPDEDNEDYQRYFPTSTLVTGYDIIFF----WVsrmIF-QSLEFTerrPFENVLIHG- 515
Cdd:PRK12267 229 I---DAL-LNYITAL------GYGSDDDELFKKFWPADVHLVGKDILRFhaiyWP---IMlMALGLP---LPKKVFAHGw 292
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 516 LIRDeqGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNgSAP-GQDVRFSYEkmdaswNFINKIwNA----------SRF 584
Cdd:PRK12267 293 WLMK--DGKMSKSKGNVVDPEELVDRYGLDALRYYLLR-EVPfGSDGDFSPE------ALVERI-NSdlandlgnllNRT 362
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 585 VimnveGMTVE----DIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwdDFCDWYIEMSKE-TLYG 659
Cdd:PRK12267 363 V-----AMINKyfdgEIPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLI--SRANKYIDETAPwVLAK 435
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 518552761 660 EDEvaKQTNRSILVHTLDQILR----LLHPIMPFVTEEIWQHI 698
Cdd:PRK12267 436 DEG--KKERLATVMYHLAESLRkvavLLSPFMPETSKKIFEQL 476
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
386-695 |
1.97e-19 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 93.29 E-value: 1.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 386 FFP-PRFnQTFLR--------WMENV------------HDWVISRQL-WWGHQIPAwyhkETGE-MYVGMEAP----ADS 438
Cdd:PRK00133 188 FFKlPRF-EEFLKewitrsgeLQPNVankmkewleeglQDWDISRDApYFGFEIPG----APGKvFYVWLDAPigyiSST 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 439 ENWLQDPDVLDtWfsSALWPfstmgwPDEDNEDYQryfptstlVTGYDIIF----FWVSrMifqsLEFTERRPFENVLIH 514
Cdd:PRK00133 263 KNLCDKRGGLD-W--DEYWK------KDSDTELYH--------FIGKDIIYfhtlFWPA-M----LEGAGYRLPTNVFAH 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 515 GLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFL-SNGSAPGQDVRFSYEKMDASWN--FINKIWN-ASR---FVIM 587
Cdd:PRK00133 321 GFLTVE-GAKMSKSRGTFIWARTYLDHLDPDYLRYYLaAKLPETIDDLDFNWEDFQQRVNseLVGKVVNfASRtagFINK 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 588 NVEGmTVEDIDLSGEktvadrwILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwdDFCDWYI------EMSKEtlygED 661
Cdd:PRK00133 400 RFDG-KLPDALADPE-------LLEEFEAAAEKIAEAYEAREFRKALREIMALA--DFANKYVddnepwKLAKQ----DG 465
|
330 340 350
....*....|....*....|....*....|....*...
gi 518552761 662 EVAKQTnrsilVHTLDQILR----LLHPIMPFVTEEIW 695
Cdd:PRK00133 466 ERLQAV-----CSVGLNLFRalaiYLKPVLPELAERAE 498
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
48-563 |
1.27e-18 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 87.97 E-value: 1.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 48 PNVTGKLHLGHAWDTTLQDMLIRQKRMQGYDTLWLPGMDHAGIatqaKVEEKLREQGVSRydlgrEKFIDqvwewkeEYA 127
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGT----KIEQKAEEEGVTP-----QELCD-------KYH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 128 GHIREQWAKMGLSLD-YSRerfTLDDGLSEAVRKVFVSLYEKELIYRGEYiinwdpqartalsdievihkeiEGAFyhms 206
Cdd:cd00814 73 EIFKDLFKWLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEY----------------------EGLY---- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 207 yeladgsgvveiattrpetmlgdtaiavHPEDERYqaligkkvilplvnkeipiiadeyvdmefgtgvvkitpahdpndf 286
Cdd:cd00814 124 ----------------------------CVSCERF--------------------------------------------- 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 287 evgnrhdLPrvnvmnedgtmnelagkyqgmdrfaarkaivadlkelgrlikietmihnvghsertgvvvEPRLSTQWFVK 366
Cdd:cd00814 131 -------LP------------------------------------------------------------EWREEEHYFFR 143
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 367 MAPLAEKAIQNQETDDAVEFFPPRFNQTfLRWMEN-VHDWVISRQLW-WGHQIPaWYHKETgeMYVGMEAP----ADSEN 440
Cdd:cd00814 144 LSKFQDRLLEWLEKNPDFIWPENARNEV-LSWLKEgLKDLSITRDLFdWGIPVP-LDPGKV--IYVWFDALigyiSATGY 219
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 441 WLQDPDvLDTWFSsalwpfstmgwpDEDNEDYQryfptstlVTGYDIIFF----WVSrmifqSLEFTERRPFENVLIHGL 516
Cdd:cd00814 220 YNEEWG-NSWWWK------------DGWPELVH--------FIGKDIIRFhaiyWPA-----MLLGAGLPLPTRIVAHGY 273
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 518552761 517 IRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRF 563
Cdd:cd00814 274 LTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
358-561 |
7.18e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 79.60 E-value: 7.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 358 RLSTQWFVKM-----APLAEKAIqnqetdDAVEFFPPRFNQTFLRWMEnvhdwvISRQLWWGHQIPaWyhKETgemyvgM 432
Cdd:cd00812 127 KLLDQWFLKYsetewKEKLLKDL------EKLDGWPEEVRAMQENWIG------CSRQRYWGTPIP-W--TDT------M 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 433 EAPADSenwlqdpdvldTW----FSSALWPFS-TMGWPDEDNEDYQRYFPTSTLVTGYDII------FFWVSRMIFqSLE 501
Cdd:cd00812 186 ESLSDS-----------TWyyarYTDAHNLEQpYEGDLEFDREEFEYWYPVDIYIGGKEHApnhllySRFNHKALF-DEG 253
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 502 FTERRPFENVLIHGLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDV 561
Cdd:cd00812 254 LVTDEPPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADF 312
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
566-687 |
2.25e-14 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 70.23 E-value: 2.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 566 EKMDASWNFINKIWNASRFVIMNVEGmTVEDIDlSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIWDDf 645
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGG-TQPKWD-NELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL- 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 518552761 646 cDWYIEMSKETLYGEDEVAKQtnRSILVHTLDQILRLLHPIM 687
Cdd:cd07375 79 -NWYLDELKPALQTEELREAV--LAVLRAALVVLTKLLAPFT 117
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
199-329 |
2.77e-14 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 71.81 E-value: 2.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 199 EGAfyHMSYELADGSGVVEIATTRPETMLGDTAIAVHPE----------DERYQALI----------------------- 245
Cdd:pfam13603 8 EGA--EITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEhplveklaekNPEVAAFIeeckntseiertsetkekegvft 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 246 GKKVILPLVNKEIPI-IADeYVDMEFGTGVVKITPAHDPNDFEVGNRHDLPRVNV----------------MNEDGTM-N 307
Cdd:pfam13603 86 GLYAIHPITGEKIPIwIAN-FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPViqpedgdldldimteaYTEEGILvN 164
|
170 180
....*....|....*....|..
gi 518552761 308 elAGKYQGMDRFAARKAIVADL 329
Cdd:pfam13603 165 --SGEFDGLDSEEAKEAIIKKL 184
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
601-696 |
7.40e-14 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 68.77 E-value: 7.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 601 GEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIWDDFcDWYIEMSKETLygedevakqtNRSILVHTLDQIL 680
Cdd:cd07959 31 EELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDL-DWYRERGGAGM----------NKDLLRRFIEVWT 99
|
90
....*....|....*.
gi 518552761 681 RLLHPIMPFVTEEIWQ 696
Cdd:cd07959 100 RLLAPFAPHLAEEIWH 115
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
303-738 |
3.15e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 67.40 E-value: 3.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 303 DGTMneLAGKYQGMDRFAARKAIVADLKELGRLIKietmihnvgHSE-------RTG---VVVeprLSTQWFV-----KM 367
Cdd:PLN02959 480 DGTM--LVGEYAGRKVQEAKPLIKKKLIEAGQAIL---------YSEpekkvmsRSGdecVVA---LTDQWYLtygeeEW 545
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 368 APLAEKAIQNQET--DDAVEFFpprfnQTFLRWMenvHDWVISRQLWWGHQIP-----------------AWY----HKE 424
Cdd:PLN02959 546 KKKAEKCLSKMNLysDETRHGF-----EHTLGWL---NQWACSRSFGLGTRIPwdeqflieslsdstiymAYYtvahLLQ 617
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 425 TGEMYVGMEAPADSENwLQDpDVLDTWFSSALWPFSTMGWPDEDNE---DYQRYFPTSTLVTGYDIIFFWVSRMIFQSLE 501
Cdd:PLN02959 618 GGDMYGKDKSSIKPEQ-MTD-EVWDFVFCGGPLPKSSDIPAELLEKmkqEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTA 695
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 502 FTERRPFENVLI---HGLIRDEqgrKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDAS-WNFINK 577
Cdd:PLN02959 696 IWAEEHWPRGFRcngHLMLNSE---KMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAiLRLTKE 772
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 578 I-WnasrfvimnVEGMTVEDIDL-SG-EKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRqlynfiwddfCDWYIEMSK 654
Cdd:PLN02959 773 IaW---------MEEVLAAESSLrTGpPSTYADRVFENEINIAIAETEKNYEAMMFREALK----------SGFYDLQAA 833
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 655 ETLYGEDEVAKQTNRSILVHTLDQILRLLHPIMPFVTEEIWQHIPHKGTSLVVADYPVVQPEydDEAASKGMEVLKELIR 734
Cdd:PLN02959 834 RDEYRLSCGSGGMNRDLVWRFMDVQTRLITPICPHYAEHVWREILKKEGFAVTAGWPVAGEP--DLTLKRANKYLQDSIV 911
|
....
gi 518552761 735 SVRN 738
Cdd:PLN02959 912 SFRK 915
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
569-698 |
3.80e-10 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 58.00 E-value: 3.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 569 DASWNFINKIWnasRFVIMNVEGmtVEDIDLSGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwddfcdw 648
Cdd:cd07958 7 EGAYRFLNRVW---RLVTELAEA--LAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELV------- 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 518552761 649 yiemskETLYGEDEVAKQtNRSILVHTLDQILRLLHPIMPFVTEEIWQHI 698
Cdd:cd07958 75 ------NALYKYKKKDAQ-HAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
389-698 |
1.15e-08 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 58.57 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 389 PRFNQTFLRwMENVHDWVIS--RQLWWGHQIPAWyhketgemyvGMEAPADsenwlqDPDVLDTWFSSALWPFSTMgwpD 466
Cdd:PLN02224 245 PRFVQPSYR-LNEVQSWIKSglRDFSISRALVDW----------GIPVPDD------DKQTIYVWFDALLGYISAL---T 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 467 EDNEDYQRY------FPTSTLVTGYDIIFF----WVSRMIFQSLEFTERrpfenVLIHGLIRDEqGRKMSKSLGNGIDPM 536
Cdd:PLN02224 305 EDNKQQNLEtavsfgWPASLHLIGKDILRFhavyWPAMLMSAGLELPKM-----VFGHGFLTKD-GMKMGKSLGNTLEPF 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 537 EVIEKYGADALRWFLSNGSAPGQDVRFSYEK----MDASW-NFINKIWNASRFVI-MNVEGMTVEDIDLSGE-----KTV 605
Cdd:PLN02224 379 ELVQKFGPDAVRYFFLREVEFGNDGDYSEDRfikiVNAHLaNTIGNLLNRTLGLLkKNCESTLVEDSTVAAEgvplkDTV 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 606 ADRWILTRLN-ETIAKVTDLFEQFEFGEAGrqlyNFIWDDFCDWYieMSKETLYGEDEVAKqtNRSILVHTLDQILRLLH 684
Cdd:PLN02224 459 EKLVEKAQTNyENLSLSSACEAVLEIGNAG----NTYMDQRAPWF--LFKQGGVSAEEAAK--DLVIILEVMRVIAVALS 530
|
330
....*....|....
gi 518552761 685 PIMPFVTEEIWQHI 698
Cdd:PLN02224 531 PIAPCLSLRIYSQL 544
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
507-585 |
4.16e-07 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 53.57 E-value: 4.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 507 PFENVLIH-GLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFLsnGSA----PgQDvrFSYEKMDASWNFINKIWNA 581
Cdd:COG0215 248 PFARYWMHnGFLTVN-GEKMSKSLGNFFTVRDLLKKYDPEVLRFFL--LSAhyrsP-LD--FSEEALEEAEKALERLYNA 321
|
....
gi 518552761 582 SRFV 585
Cdd:COG0215 322 LRRL 325
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
573-696 |
4.59e-06 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 46.71 E-value: 4.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518552761 573 NFINKIWNasrFVIMNVEGMTVEDidlsGEKTVADRWILTRLNETIAKVTDLFEQFEFGEAGRQLYNFIwdDFCDWYIEM 652
Cdd:cd07957 11 NLVNRTLN---MASKYFGGVVPEF----GGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELA--RAANKYIDE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 518552761 653 SketlygED-EVAKQTNRSIL---VHTLDQILR----LLHPIMPFVTEEIWQ 696
Cdd:cd07957 82 T------APwKLAKEEDPERLatvLYVLLELLRilaiLLSPFMPETAEKILD 127
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
506-551 |
2.94e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 46.03 E-value: 2.94e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 518552761 506 RPFENVLIH-GLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFL 551
Cdd:cd00672 156 KPFARYWLHtGHLTID-GEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
516-564 |
1.76e-03 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 41.72 E-value: 1.76e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 518552761 516 LIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFLSNGSAPGQDVRFS 564
Cdd:PRK00750 272 LFLDKKGEKISKSKGNVITIEDWLEYAPPESLRLFMFARPKPAKRLDFD 320
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
507-551 |
3.28e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 40.43 E-value: 3.28e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 518552761 507 PFENVLIH-GLIRDEqGRKMSKSLGNGIDPMEVIEKYGADALRWFL 551
Cdd:pfam01406 236 QLANYWLHnGHVMID-GEKMSKSLGNFFTIRDVLKRYDPEILRYFL 280
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
516-551 |
6.76e-03 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 40.18 E-value: 6.76e-03
10 20 30
....*....|....*....|....*....|....*.
gi 518552761 516 LIRDEQGRKMSKSLGNGIDPMEVIEKYGADALRWFL 551
Cdd:COG1384 279 LFLDENGEKISKSKGNGLTVEEWLEYAEPESLRYFM 314
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
511-568 |
8.86e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 39.75 E-value: 8.86e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518552761 511 VLIH---GLIRDEQGRKMSKSLGNGIDPMEVIE-----------------KYGADALRWF-LSNgsAPGQDVRFSYEKM 568
Cdd:PRK01611 306 VLLHqmvGLVRGGEGVKMSTRAGNVVTLDDLLDeavgrarelieekeiaeAVGIDAVRYFdLSR--SRDKDLDFDLDLA 382
|
|
| |
