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Conserved domains on  [gi|518573014|ref|WP_019743221|]
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MULTISPECIES: cupin domain-containing protein [Bacillus]

Protein Classification

cupin domain-containing protein( domain architecture ID 14449023)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

CATH:  2.60.120.10
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 13-156 3.58e-56

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


:

Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 174.70  E-value: 3.58e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  13 KYSFDLNQSPLVKYDQHNLINVLGKKQLNSLDQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPfTKKLST 92
Cdd:cd20306    1 PHLFSLEDSNPFFESEGGSIRQATADQLPVLKGLSIYRLRLSPGGIREPHWHPNANELGYVISGEARVSILDP-TGSLDT 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518573014  93 YTITPGQVANVPQGWWHYEVALQ-DKTHLLAIFNASTPEVILGSDLLTLTPSHIMAHTYCMNETQ 156
Cdd:cd20306   80 FTVKPGQVVFIPQGWLHWIENVGdEEAHLLIFFNHETPEDIGLSDSLRATPPEVLGNTYGVDAFF 144
 
Name Accession Description Interval E-value
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 13-156 3.58e-56

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 174.70  E-value: 3.58e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  13 KYSFDLNQSPLVKYDQHNLINVLGKKQLNSLDQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPfTKKLST 92
Cdd:cd20306    1 PHLFSLEDSNPFFESEGGSIRQATADQLPVLKGLSIYRLRLSPGGIREPHWHPNANELGYVISGEARVSILDP-TGSLDT 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518573014  93 YTITPGQVANVPQGWWHYEVALQ-DKTHLLAIFNASTPEVILGSDLLTLTPSHIMAHTYCMNETQ 156
Cdd:cd20306   80 FTVKPGQVVFIPQGWLHWIENVGdEEAHLLIFFNHETPEDIGLSDSLRATPPEVLGNTYGVDAFF 144
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 46-149 2.54e-22

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 87.33  E-value: 2.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  46 VSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPFTkKLSTYTITPGQVANVPQGWWHYEVALQDKT-HLLAIF 124
Cdd:COG2140    3 LAGGLTVLEPGGVREEHWHPNAAEWYYVLSGEARMTVQDPPG-RARTVDVGPGDVVYVPPGYGHYIINTGDEPlVFLAVF 81

                         90       100
                 ....*....|....*....|....*
gi 518573014 125 NASTpevilGSDLLTLTPSHIMAHT 149
Cdd:COG2140   82 DDDA-----GSDYGTISLSGWLAHT 101
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 39-158 1.29e-21

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 86.18  E-value: 1.29e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014    39 QLNSLDqVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPFTKKLSTYTITPGQVANVPQGWWHYEVALQDKT 118
Cdd:smart00835  24 ALNGLG-ISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGNKVYDARLREGDVFVVPQGHPHFQVNSGDEN 102

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 518573014   119 HLLAIFNASTP-EVIL---GSDLLTLTPSHIMAHTYCMNETQWK 158
Cdd:smart00835 103 LEFVAFNTNDPnRRFFlagRNSVLRGLPPEVLAAAFGVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 18-128 1.21e-09

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 54.65  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014   18 LNQSPLVKYDQHNL--INVLGKKQLNSLdQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNP------FTKK 89
Cdd:pfam00190   4 LEPGPTYNPEGGRVttVNSKNLPGLNTL-GISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPgngnrvFHKV 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 518573014   90 LStytitPGQVANVPQGWWHYEVAlQDKTHLLAIFNAST 128
Cdd:pfam00190  83 LR-----EGDVFVVPQGLPHFQYN-IGDEPAVAFVAFDT 115
bicupin_oxalic TIGR03404
bicupin, oxalate decarboxylase family; Members of this protein family are defined as bicupins ...
 60-164 4.25e-04

bicupin, oxalate decarboxylase family; Members of this protein family are defined as bicupins as they have two copies of the cupin domain (pfam00190). Two different known activities for members of this family are oxalate decarboxylase (EC 4.1.1.2) and oxalate oxidase (EC 1.2.3.4), although the latter activity has more often been found in distantly related monocupin (germin) proteins.


Pssm-ID: 274565 [Multi-domain]  Cd Length: 367  Bit Score: 40.38  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014   60 EPHYHQNAAELVYCIAGSAAVSMLNPfTKKLSTYTITPGQVANVPQGWWHYEVALQDKT-HLLAIFNASTPEVILGSDLL 138
Cdd:TIGR03404 259 ELHWHPNADEWQYFIQGQARMTVFAA-GGNARTFDYQAGDVGYVPRNMGHYVENTGDETlVFLEVFKADRFADVSLNQWL 337

                          90       100
                  ....*....|....*....|....*....
gi 518573014  139 TLTPSHIMAHTYCMNE---TQWKQATQPV 164
Cdd:TIGR03404 338 ALTPPQLVAAHLNLDDeviDSLKKEKQPV 366
PLN00212 PLN00212
glutelin; Provisional
 40-112 1.10e-03

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 39.03  E-value: 1.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518573014  40 LNsLDQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPFTKKLSTYTITPGQVANVPQgwwHYEV 112
Cdd:PLN00212 343 LN-LIQMSATRVNLYQNALLSPFWNVNAHSVVYITQGRARVQVVSNNGKTVFNGVLRPGQLLIIPQ---HYAV 411
 
Name Accession Description Interval E-value
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 13-156 3.58e-56

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 174.70  E-value: 3.58e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  13 KYSFDLNQSPLVKYDQHNLINVLGKKQLNSLDQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPfTKKLST 92
Cdd:cd20306    1 PHLFSLEDSNPFFESEGGSIRQATADQLPVLKGLSIYRLRLSPGGIREPHWHPNANELGYVISGEARVSILDP-TGSLDT 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518573014  93 YTITPGQVANVPQGWWHYEVALQ-DKTHLLAIFNASTPEVILGSDLLTLTPSHIMAHTYCMNETQ 156
Cdd:cd20306   80 FTVKPGQVVFIPQGWLHWIENVGdEEAHLLIFFNHETPEDIGLSDSLRATPPEVLGNTYGVDAFF 144
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 46-149 2.54e-22

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 87.33  E-value: 2.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  46 VSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPFTkKLSTYTITPGQVANVPQGWWHYEVALQDKT-HLLAIF 124
Cdd:COG2140    3 LAGGLTVLEPGGVREEHWHPNAAEWYYVLSGEARMTVQDPPG-RARTVDVGPGDVVYVPPGYGHYIINTGDEPlVFLAVF 81

                         90       100
                 ....*....|....*....|....*
gi 518573014 125 NASTpevilGSDLLTLTPSHIMAHT 149
Cdd:COG2140   82 DDDA-----GSDYGTISLSGWLAHT 101
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 39-158 1.29e-21

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 86.18  E-value: 1.29e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014    39 QLNSLDqVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPFTKKLSTYTITPGQVANVPQGWWHYEVALQDKT 118
Cdd:smart00835  24 ALNGLG-ISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGNKVYDARLREGDVFVVPQGHPHFQVNSGDEN 102

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 518573014   119 HLLAIFNASTP-EVIL---GSDLLTLTPSHIMAHTYCMNETQWK 158
Cdd:smart00835 103 LEFVAFNTNDPnRRFFlagRNSVLRGLPPEVLAAAFGVSAEEVR 146
cupin_OxDC cd02240
Oxalate decarboxylase (OxDC), cupin domain; Oxalate decarboxylase (OxDC; EC 4.1.1.2) is a ...
 60-150 3.13e-13

Oxalate decarboxylase (OxDC), cupin domain; Oxalate decarboxylase (OxDC; EC 4.1.1.2) is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds and both domains are included in this alignment. Each OxDC cupin domain contains one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380367 [Multi-domain]  Cd Length: 145  Bit Score: 64.04  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  60 EPHYHQNAAELVYCIAGSAAVSMLNPfTKKLSTYTITPGQVANVPQGWWHY-EVALQDKTHLLAIFNASTPEVILGSDLL 138
Cdd:cd02240   41 ELHWHPNTAEWQYVISGSARVTVFDE-DGRFETFNLGAGDVGYVPSGSGHHiENIGDEDAEFLLIFDDGTFADVSLPWWL 119

                         90
                 ....*....|..
gi 518573014 139 TLTPSHIMAHTY 150
Cdd:cd02240  120 AMTPEEVLAATL 131
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 18-128 1.21e-09

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 54.65  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014   18 LNQSPLVKYDQHNL--INVLGKKQLNSLdQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNP------FTKK 89
Cdd:pfam00190   4 LEPGPTYNPEGGRVttVNSKNLPGLNTL-GISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPgngnrvFHKV 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 518573014   90 LStytitPGQVANVPQGWWHYEVAlQDKTHLLAIFNAST 128
Cdd:pfam00190  83 LR-----EGDVFVVPQGLPHFQYN-IGDEPAVAFVAFDT 115
cupin_OxDC_C cd20305
Oxalate decarboxylase (OxDC), C-terminal cupin domain; This model represents the C-terminal ...
 60-147 1.72e-08

Oxalate decarboxylase (OxDC), C-terminal cupin domain; This model represents the C-terminal cupin domain of oxalate decarboxylase (OxDC; EC 4.1.1.2), a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380439 [Multi-domain]  Cd Length: 153  Bit Score: 51.43  E-value: 1.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  60 EPHYHQNAAELVYCIAGSAAVSMLNPfTKKLSTYTITPGQVANVPQGWWHY-EVALQDKTHLLAIFNASTPEVILGSDLL 138
Cdd:cd20305   48 ELHWHPNADEWQYYISGKARMTVFAS-GGRARTFDFQAGDVGYVPRGYGHYiENTGDEPLEFLEVFNSGRYQDISLSQWL 126


                 ....*....
gi 518573014 139 TLTPSHIMA 147
Cdd:cd20305  127 ALTPPDLVA 135
cupin_OxOx cd02241
Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3. ...
 61-112 3.32e-06

Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3.4) catalyzes the manganese-dependent oxidative decarboxylation of oxalate to carbon dioxide and hydrogen peroxide (H2O2). It is widespread in fungi and various plant tissues and may play a role in plant signaling and defense. This enzyme has been employed in a widely used assay for detecting urinary oxalate levels. Also, the gene encoding OxOx from barley roots has been expressed in oilseed rape in order to provide a defense against externally supplied oxalic acid. In germin, the predominant protein produced during the early phase of wheat germination, it is believed that H2O2 production is employed as a defense mechanism in response to infection by pathogens. Germin is also a marker of growth onset in cell walls in germinating cereals. The H2O2 produced by OxOx, together with the Ca2+ released by degradation of calcium oxalate, are thought to mediate cell wall cross-linking at high concentrations. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380368  Cd Length: 191  Bit Score: 45.66  E-value: 3.32e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 518573014  61 PHYHQNAAELVYCIAGSAAVSMLNPFTKKLSTYTITPGQVANVPQGWWHYEV 112
Cdd:cd02241   85 PHTHPRATELLYVVEGTLYVGFVDENGNRLFTKTLNPGDVFVFPQGLIHFQF 136
bicupin_oxalic TIGR03404
bicupin, oxalate decarboxylase family; Members of this protein family are defined as bicupins ...
 60-164 4.25e-04

bicupin, oxalate decarboxylase family; Members of this protein family are defined as bicupins as they have two copies of the cupin domain (pfam00190). Two different known activities for members of this family are oxalate decarboxylase (EC 4.1.1.2) and oxalate oxidase (EC 1.2.3.4), although the latter activity has more often been found in distantly related monocupin (germin) proteins.


Pssm-ID: 274565 [Multi-domain]  Cd Length: 367  Bit Score: 40.38  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014   60 EPHYHQNAAELVYCIAGSAAVSMLNPfTKKLSTYTITPGQVANVPQGWWHYEVALQDKT-HLLAIFNASTPEVILGSDLL 138
Cdd:TIGR03404 259 ELHWHPNADEWQYFIQGQARMTVFAA-GGNARTFDYQAGDVGYVPRNMGHYVENTGDETlVFLEVFKADRFADVSLNQWL 337

                          90       100
                  ....*....|....*....|....*....
gi 518573014  139 TLTPSHIMAHTYCMNE---TQWKQATQPV 164
Cdd:TIGR03404 338 ALTPPQLVAAHLNLDDeviDSLKKEKQPV 366
PLN00212 PLN00212
glutelin; Provisional
 40-112 1.10e-03

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 39.03  E-value: 1.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518573014  40 LNsLDQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNPFTKKLSTYTITPGQVANVPQgwwHYEV 112
Cdd:PLN00212 343 LN-LIQMSATRVNLYQNALLSPFWNVNAHSVVYITQGRARVQVVSNNGKTVFNGVLRPGQLLIIPQ---HYAV 411
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 51-124 1.14e-03

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 36.31  E-value: 1.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518573014  51 IYLSKSKVVEPHYHQNAAELVYCIAGSAAVsmlnpFTKKLSTYTITPGQVANVPQGWWHYEVALQDK-THLLAIF 124
Cdd:cd02208    4 VTLPPGTSSPPHWHPEQDEIFYVLSGEGEL-----TLDDGETVELKAGDIVLIPPGVPHSFVNTSDEpAVFLVVS 73
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
44-109 4.93e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 35.50  E-value: 4.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518573014  44 DQVSLLDIYLSKSKVVEPHYHQNAAELVYCIAGSAAVSMLNpftkklSTYTITPGQVANVPQGWWH 109
Cdd:COG0662   25 ERLSVKRITVPPGAELSLHVHPHRDEFFYVLEGTGEVTIGD------EEVELKAGDSVYIPAGVPH 84
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
44-125 9.36e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 34.44  E-value: 9.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573014  44 DQVSLLDIYLSKSKVVEPHYHQnAAELVYCIAGSAAVSMLNPftkklsTYTITPGQVANVPQGWWHYEVALQDKT-HLLA 122
Cdd:COG1917   21 DELEVVRVTFEPGARTPWHSHP-GEELIYVLEGEGEVEVGGE------EYELKPGDVVFIPPGVPHAFRNLGDEPaVLLV 93


                 ...
gi 518573014 123 IFN 125
Cdd:COG1917   94 VFS 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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