|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
28-431 |
0e+00 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 600.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 28 IFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLM 107
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 108 CFGSLLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLILL 187
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 188 QQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESF---TKKEKAKESAMRTLMRHPKELMTVVGLTMGGTLAFY 264
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFeaiAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 265 TYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAF 344
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 345 FLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIAVSLMVY 424
Cdd:cd17367 321 ALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVY 400
|
....*..
gi 518653971 425 VTMKDTR 431
Cdd:cd17367 401 LRMPETR 407
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
11-423 |
2.29e-177 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 502.42 E-value: 2.29e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 11 STAAKAQERTTSSRIKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLY 90
Cdd:PRK10406 7 TADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 91 ADKVGRKKALMASVYLMCFGSLLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQY 170
Cdd:PRK10406 87 ADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQY 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 171 VTLISGQLIALAVLILLQQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAKESAMRTLMRHPKELM 250
Cdd:PRK10406 167 VTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEAGSLKGLWRNRRAFI 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 251 TVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPI 330
Cdd:PRK10406 247 MVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 331 LTTLHTIQSWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYY 410
Cdd:PRK10406 327 LSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIGMETAFF 406
|
410
....*....|...
gi 518653971 411 WYVTACIAVSLMV 423
Cdd:PRK10406 407 WYVTLMAVVAFLV 419
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
34-419 |
1.56e-143 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 415.13 E-value: 1.56e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 34 GNMVEWYDWYVYAAFSLYFAKAFFP-KGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSL 112
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPpSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 113 LIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLILLQQVLT 192
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 193 TEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAKESAMR----TLMRHPKELMTVVGLTMGGTLAFYTYTT 268
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGpiaeTLTKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 269 YMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAFFLIM 348
Cdd:TIGR00883 241 YLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLVL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518653971 349 AALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIAV 419
Cdd:TIGR00883 321 GMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALAL 391
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
26-422 |
1.70e-99 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 303.29 E-value: 1.70e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 26 KSIFSGSVGNMVEWYDWYVYA-AFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASV 104
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGtAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 105 YLMCFGSLLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVL 184
Cdd:cd17369 82 LLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 185 ILLQQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTK----KEKAKESAMRTLMRHPKELMTVVGLTMGGT 260
Cdd:cd17369 162 LLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRakeaGQVVRAPLVEVLRRHWRALLLAIGLRLAEN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 261 LAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSW 340
Cdd:cd17369 242 VLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTW 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 341 WGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALW-FKSIGMETGYYWYVTACIAV 419
Cdd:cd17369 322 LIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATAlVAATGSWWPVALYLAALAVI 401
|
...
gi 518653971 420 SLM 422
Cdd:cd17369 402 SLV 404
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
28-430 |
8.15e-92 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 283.50 E-value: 8.15e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 28 IFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLM 107
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 108 CFGSLLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLILL 187
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 188 QQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESF--TKKEKAKESAMRTLMRHPKELMTVVGLTMGGTLAFYT 265
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFleRKARPTRRELFALLANNRRIILLGMLLVAGSTVTFYF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 266 YTTYMQKYLVNTVGMSISDS---TTISAATLFLFMclqPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSwwg 342
Cdd:cd17368 241 TTVYTPTYAKTVLGLSARDSflvTLLAGVANFIWA---PLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPS--- 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 343 aFFLIMAALIIVSGYTSINAVVK----AELFPTEIRALGVGLPYALTVSIFGGTAEYIALWF-KSIGMETGYYWYVTACI 417
Cdd:cd17368 315 -FGRLLLVLLVLSFFFGMYGGAMvvalVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLiELTGSPLAPAWYLMGAA 393
|
410
....*....|...
gi 518653971 418 AVSLMVYVTMKDT 430
Cdd:cd17368 394 LLGLLATLMLRET 406
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
32-430 |
2.67e-79 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 250.35 E-value: 2.67e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 32 SVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGS 111
Cdd:cd17366 5 ALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAAST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 112 LLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLILLQQVL 191
Cdd:cd17366 85 FCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 192 TTEQLYAWGWRIPFAIGALCAVVALYLRRgmeetesftkkekakesamrtlmrhpkELMTVVGLTMGGTLAFYTYTTYMQ 271
Cdd:cd17366 165 TEAQMLDWGWRIPFLIAAPLGLVGLYLRR---------------------------PLLICIGLVLVFNVTNYMLLSYMP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 272 KYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPiLIAFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAAL 351
Cdd:cd17366 218 SYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKP-VYAAGLAGLLVLAVPAFLLMNSGSIAAIFIGLLVLG 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 352 IIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSI-GMETGYYWYVTACIAVSLMVYVTMKDT 430
Cdd:cd17366 297 LLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSAtGNPLMPAYYLMVAAVVGLVAVLFLTET 376
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
12-399 |
3.33e-79 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 251.79 E-value: 3.33e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 12 TAAKAQERTTSSRIKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYA 91
Cdd:PRK15075 1 MSTMTPAASRESKARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 92 DKVGRKKALMASVYLMCFGSLLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYV 171
Cdd:PRK15075 81 DRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 172 TLISGQLIALAVLILLQQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFtkKEKAKESAMRTLMRHPKELMT 251
Cdd:PRK15075 161 SQQVAVVFAALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEF--LARKHRPSMREIFRSLAANWR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 252 VVGLTMG----GTLAFYTYTTYMQKYLVNTVGMSISDS---TTISAATLFLFMclqPIIGGLSDKIGRRPILIAFGVLGT 324
Cdd:PRK15075 239 IVLAGMLmvamTTVSFYLITVYTPTFGKTVLHLSAADSllvTLCVGVSNFIWL---PIGGALSDRIGRRPVLIAFTVLAI 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518653971 325 LFTVPILTTLHTIQSwwgaFFLIMAALIIVSG-YTSIN-AVVKA--ELFPTEIRALGVGLPYALTVSIFGGTAEYIALW 399
Cdd:PRK15075 316 LTAYPALSWLVAAPS----FARMLAVELWLSFlYGSYNgAMVVAltEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTW 390
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
26-430 |
1.88e-64 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 214.96 E-value: 1.88e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 26 KSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVY 105
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 106 LMCFGSLLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLI 185
Cdd:PRK10642 96 IMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 186 LLQQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTK-------------KEKAKESAMRTLMRHPKELMTV 252
Cdd:PRK10642 176 LISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQhvdkleqgdreglQDGPKVSFKEIATKHWRSLLTC 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 253 VGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPilt 332
Cdd:PRK10642 256 IGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLAIP--- 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 333 TLHTIQSwwGAFFLIMAALIIVS----GYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIG--ME 406
Cdd:PRK10642 333 AFILINS--NVIGLIFAGLLMLAvilnCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESTQnlMM 410
|
410 420
....*....|....*....|....
gi 518653971 407 TGYYWYVTAciAVSLMVYVTMKDT 430
Cdd:PRK10642 411 PAYYLMVVA--VIGLITGVTMKET 432
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-423 |
2.91e-64 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 210.54 E-value: 2.91e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 28 IFSGSVGNMVEWYDWYVYAAFSLYFAKAFfpkgDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLM 107
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 108 CFGSLLIALSPGyeiigigaPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLIll 187
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS-- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 188 qqVLTTEQLYAWGWRIPFAIGALCAVVALYLRRgmeetesftkkekakesamRTLMrhpkelmtVVGLTMGGTLAFYTYT 267
Cdd:cd17316 147 --LLIPLLSGDWGWRILFLIGALPALLALLLRR-------------------RTLL--------LILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 268 TYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILttLHTIQSWWGAFFLI 347
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF--YLLSGSPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518653971 348 MAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIAVSLMV 423
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-433 |
3.73e-60 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 202.27 E-value: 3.73e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 1 MDNSNTVPLGSTAAKAQERTTssriKSIFSGSVGNMVEWYDWYVYA-AFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLM 79
Cdd:PRK09952 1 MDSTLISTRPDEGTLSLSRAR----RAALGSFAGAVVDWYDFLLYGiTAALVFNREFFPQVSPAMGTLAAFATFGVGFLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 80 RPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEIIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATK 159
Cdd:PRK09952 77 RPLGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 160 ERRGFYSSFQYVTLISGQLIALAVLILLQQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTKK------EK 233
Cdd:PRK09952 157 NKKAFYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQqheqaaAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 234 AKESAMRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRR 313
Cdd:PRK09952 237 KRIPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 314 PILIAFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTA 393
Cdd:PRK09952 317 RVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFT 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 518653971 394 EYIALWFKSIGmetGYYW-----YVTACIAVSLMVYVTMKDTRKH 433
Cdd:PRK09952 397 PFIAAALVTYF---GGSWhsvaiYLLAGCLISAMTALLMKDNQRA 438
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-435 |
9.19e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 135.78 E-value: 9.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 22 SSRIKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFfpkGDTTAQLlntAAIFAVGFLMRPIGGWLMGLYADKVGRKKALM 101
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF---GLSAAQL---GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 102 ASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIAl 181
Cdd:COG2223 75 IGLLLLGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 182 avlillqQVLTTEQLYAWGWRIPFAI-GALCAVVALYLRRGMEETESF-TKKEKAKESAMRTLMRHPKELMTVVGLTMGG 259
Cdd:COG2223 146 -------AFLAPLLIAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGaAAAAKASLRDQLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 260 TlAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHtiqS 339
Cdd:COG2223 219 G-SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG---S 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 340 WWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLpyALTVSIFGGTAeyIALWFKSIGMETGYY----WYVTA 415
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGL--VGAAGGLGGFL--GPLLFGALLDATGSYtaafLVFAV 370
|
410 420
....*....|....*....|
gi 518653971 416 CIAVSLMVYVTMKDTRKHSR 435
Cdd:COG2223 371 LALVALVLTLLLYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-380 |
2.08e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 123.16 E-value: 2.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 19 RTTSSRIKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFfpkGDTTAQLlntAAIFAVGFLMRPIGGWLMGLYADKVGRKK 98
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL---GASPAQA---GLVVTAYLLGAALGAPLAGRLADRFGRRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 99 ALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQL 178
Cdd:COG2814 77 VLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 179 IAlavlillqQVLTTEQLYAWGWRIPFAIGALCAVVALYL-RRGMEETESFTKKEKAkeSAMRTLMRHPkELMTVVGLTM 257
Cdd:COG2814 149 LG--------PLLGGLLADLFGWRWVFLVNAVLALLALLLlLRLLPESRPAARARLR--GSLRELLRRP-RLLLLLLLAF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 258 GGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAfGVLGTLFTVPILTTLHTI 337
Cdd:COG2814 218 LLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI-GLLLLALGLLLLALAGSL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 518653971 338 QSWWGAFFLIMAALIIVsgYTSINAVVkAELFPTEIRALGVGL 380
Cdd:COG2814 297 WLLLLALFLLGFGFGLL--FPLLQALV-AELAPPEARGRASGL 336
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
82-384 |
2.12e-27 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 112.78 E-value: 2.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEIigigapilLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17371 49 IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARH 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 162 RGFYSSFQYvtliSGQLIALAVLILLQQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAKES---- 237
Cdd:cd17371 121 RGKALGYVQ----SGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHfadr 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 238 -AMRTLMRHPKELMTVVGLTMGGTL--AFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRP 314
Cdd:cd17371 197 pSLRELFSPPLLRTTLLASLLATGAlgGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN 276
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518653971 315 ILIAFGVLGTLFTVPILT-TLHTIQSWWGAFFLIMAALIIVSGYTSInavvKAELFPTEIRALGVGLPYAL 384
Cdd:cd17371 277 NFALFALGSAISILLYFFlPLSPTLILILGFPLGFFASGPFSGMGAY----LTELFPTAVRATAQGFCYNV 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-432 |
3.26e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 108.80 E-value: 3.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 17 QERTTSSRIKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFfpkGDTTAQLlntAAIFAVGFLMRPIGGWLMGLYADKVGR 96
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL---GLSAAQL---GLLASAFFLGYALGQIPAGLLADRFGR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 97 KKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFqyvtLISG 176
Cdd:COG2271 75 RRVLAIGLLLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGI----FNAG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 177 QLIALAVLILLQQVLTTeqlyAWGWRIPFAIGALCAVVALYLRrgmeetesftkkekakesamrtlmrhpkeLMTVVGLT 256
Cdd:COG2271 143 GPLGGALAPPLLGWLLA----AFGWRAAFLILGLPGLLLALLR-----------------------------FWLLALAY 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 257 MGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAfgVLGTLFTVPILTTLHT 336
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL--AIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 337 IQSWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLpyALTVSIFGG--TAEYIALWFKSIGMETGYYWYVT 414
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL--VNTFGFLGGalGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|....*...
gi 518653971 415 ACIAVSLMVYVTMKDTRK 432
Cdd:COG2271 346 LALLAALLALLLLRETRK 363
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-326 |
4.10e-26 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 107.20 E-value: 4.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 16 AQERTTSSRIKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFfpkGDTTAQLlntAAIFAVGFLMRPIGGWLMGLYADKVG 95
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL---GASSAQL---GWIVSAYLLGRAIGLLLFGRLGDRYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 96 RKKALMASVYLMCFGSLLIALSPGyeiigigaPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLIS 175
Cdd:COG0477 78 RKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 176 GQLIALAVLILLqqvltteqLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAKESAMRTLMRhPKELMTVVGL 255
Cdd:COG0477 150 GLALGPLLGGLL--------VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAA-LALALLALLL 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518653971 256 TMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLF 326
Cdd:COG0477 221 LLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
32-430 |
2.28e-25 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 107.74 E-value: 2.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 32 SVGNMVEWYDWYVYAAFSLYFAKAFFPKGDT--------TAQLLNTAAIFAVGflmRPIGGWLMGLYADKVGRKKALMAS 103
Cdd:pfam00083 6 ALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKsvsslaalSVLSGLIVSIFSVG---CFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 104 VYLMCFGSLLIALSPGYeiigiGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAV 183
Cdd:pfam00083 83 NVLFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 184 LillqqVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFT----KKEKAKESAMR------------------- 240
Cdd:pfam00083 158 G-----LGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLvekgRLEEAREVLAKlrgvpdvdreldeikdsle 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 241 --------------TLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIigGL 306
Cdd:pfam00083 233 agqeaekaswkelfSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAI--FL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 307 SDKIGRRPILI--AFG--VLGTLFTVPILTTLHTiQSWWGAFFLIMAALIIVS---GYTSINAVVKAELFPTEIRALGVG 379
Cdd:pfam00083 311 VDRFGRRPLLLlgAAGmaICFVILGIVALLGVSK-SDWAGIVAIVFIALFIAFfamGWGPVPWVIVSELFPLSVRSKAMA 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 518653971 380 LPYALTVsIFGGTAEYIALW-FKSIGMeTGYYWYVTACIAVS-LMVYVTMKDT 430
Cdd:pfam00083 390 LATAANW-LANFLIGFLFPIiTDAIGL-GYTFFIFAGLLVLFiIFVFFFVPET 440
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
26-243 |
8.69e-22 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 97.46 E-value: 8.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 26 KSIFSGSVGNMVEWYDwYVYAAFSLYFAKAFFPKGDTTAQLLNTAAifavgFLMRPIGGWLMGLYADKVGRKKALMASVY 105
Cdd:PRK03893 20 KAFSAAWLGYLLDGFD-FVLITLVLTEVQGEFGLTTVQAASLISAA-----FISRWFGGLLLGAMGDRYGRRLAMVISIV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 106 LMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFqyvtLISGQLIAlavli 185
Cdd:PRK03893 94 LFSVGTLACGFAPGY--------WTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGF----LISGFSIG----- 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518653971 186 llqqVLTTEQLYA-----WGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAKEsAMRTLM 243
Cdd:PRK03893 157 ----AVVAAQVYSlvvpvWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKA-PVRTMV 214
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
82-424 |
3.38e-19 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 88.78 E-value: 3.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 162 RGFYSSFQYVTLISGQLIALAVLILLQQVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFtkkekakesamrT 241
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------L 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 242 LMRHPKELMTVVGLT-----MGGTLAFYTYTTYMQKylvntVGMSISDS--TTISAATLFLFMCLQPIIggLSDKIGRRP 314
Cdd:cd17359 191 VSKGKPILIIGIGLAifqqfVGINVIFYYGPEIFQN-----AGFSENAAllQTIGIGVVNVIFTIIAIL--LVDKVGRKP 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 315 ILI--AFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAALIIVSGYTSINA---VVKAELFPTEIRALGVGLpyaltVSIF 389
Cdd:cd17359 264 LLLigSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPvtwVLLSEIFPNRIRGLAMGI-----AVFF 338
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 518653971 390 GGTAEYIALWF-----KSIGMETGYYWYVTACIAVSLMVY 424
Cdd:cd17359 339 LWIANFLVSLTfpillAAFGLAFTFLIFAVICVLAFLFVW 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-380 |
3.09e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.55 E-value: 3.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 32 SVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMrPIGGWLmglyADKVGRKKALMASVYLMCFGS 111
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRL----SDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 112 LLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALavlillqqVL 191
Cdd:pfam07690 77 LLLLFASSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP--------LL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 192 TTEQLYAWGWRIPF---AIGALCAVVALYLRRGMEETESFTKKEKAKESAMRTL--MRHPKELMTVVGLTMGGtLAFYTY 266
Cdd:pfam07690 141 GGLLASLFGWRAAFlilAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWkaLLRDPVLWLLLALLLFG-FAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 267 TTYMQKYlVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAFFL 346
Cdd:pfam07690 220 LTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
|
330 340 350
....*....|....*....|....*....|....
gi 518653971 347 IMAALIIVSGYTSINAVVkAELFPTEIRALGVGL 380
Cdd:pfam07690 299 LLLGFGFGLVFPALNALV-SDLAPKEERGTASGL 331
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
82-364 |
1.15e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 84.14 E-value: 1.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 162 RGFYSSFQYVTLISGQLIAlavlillqQVLTTEQLYAWGWRIPF-AIGALCAVVALYLRRGMEETESFTKKEKAKESAMR 240
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLG--------RPLGGLLGQLLGWRAAFlAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 241 TLMRHPKeLMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSisdSTTISAAtLFLF----MCLQPIIGGLSDKIGRRPIL 316
Cdd:cd17324 193 LLLRNPR-LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS---SSAIIGL-LLLFgvagVVGSPLAGRLADRGGRRALL 267
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 518653971 317 IAFGVLGTLFTVPILTTLHTIqswwgafFLIMAALIIVSGYTSINAVV 364
Cdd:cd17324 268 IALLLLAAALLLLTLLGPSPL-------LLLVGLVLWGLGFFAAHSAL 308
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-380 |
5.73e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.85 E-value: 5.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 72 IFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSAT 151
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 152 YLSEMATKERRG----FYSSFQYVTLISGQLIALAVlillqqvltteqLYAWGWRIPFAIGALCAVVALYLR-RGMEETE 226
Cdd:cd17325 108 LIADIAPPEERGramgIFSSAIGLGFLIGPLLGGLL------------ADALGYRAPFLVCAALALLALVLAlLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 227 SFTKKEKAKESAMRTLMR---HPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPII 303
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRlllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518653971 304 GGLSDKIGRRPiLIAFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAALIIVSgyTSINAVVkAELFPTEIRALGVGL 380
Cdd:cd17325 256 GKLSDRIGRKP-LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVF--PATLALL-ADIVPPEGRGTAMGL 328
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-425 |
5.93e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.09 E-value: 5.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 32 SVGNMVEWYDWYVYAAFSLYFAKAFfpkGDTTAQLLNTAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGS 111
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSF---GLSASQLGLLFALFSLGYA---LLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 112 LLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSATYLSEMATKERR----GFYSSFQYVTLISGQLIALAVLill 187
Cdd:cd06174 76 LLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERgralGLLQAFGSVGGILGPLLGGILA--- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 188 qqvltteQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAKESAMRTLMRHPKE------LMTVVGLTMGGTL 261
Cdd:cd06174 145 -------SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRvlknpgLWLLLLAIFLVNL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 262 AFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDK-IGRRPILIAFGVLGTLFTVPILTTLHTIQSW 340
Cdd:cd06174 218 AYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 341 WGAFFLimaaLIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIAVS 420
Cdd:cd06174 298 LLLLLL----GFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLA 373
|
....*
gi 518653971 421 LMVYV 425
Cdd:cd06174 374 AILLL 378
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
72-391 |
1.19e-16 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 80.71 E-value: 1.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 72 IFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGyeiigigaPILLVFARLLQGLSVGGEYGTSAT 151
Cdd:cd17365 39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--------VLQLALLRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 152 YLSEMATKERRGFYSSFQYVTLISGQLIALavlillqqVLTTEQLYAWGWRIPFAIGALCAVVALYLRRGmeetesftkk 231
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYPLGAALGG--------FLAAALIPAFGWRSVFLLGGVPPLILLPLLRG---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 232 ekakesamrTLMrhpkelmtVVGLTMGGTLAFYTYTTYMQKyLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIG 311
Cdd:cd17365 173 ---------TLL--------LWVTFFMGLLLVYLLNSWLPK-LMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 312 RRPILIAFGVLGTLFTVPILTTLHtiqSWWGAFFLIMAALIIVSG-YTSINAVVkAELFPTEIRALGVGlpYALTVSIFG 390
Cdd:cd17365 235 PKRVLALFFALGAVSLALLGVSPA---SLVLLYVLVFLAGACVNGaQVGLYALA-ARFYPTEVRATGVG--WALGVGRLG 308
|
.
gi 518653971 391 G 391
Cdd:cd17365 309 A 309
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
26-408 |
9.85e-16 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 78.82 E-value: 9.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 26 KSIFSGSVGNMVEWYDwYVYAAFSLYFAKAFFPKGDTTAQLLNTAAifavgFLMRPIGGWLMGLYADKVGRKKALMASVY 105
Cdd:PRK12307 18 NALFSAWLGYVFDGFD-FMLIFYIMYLIKADLGLTDMEGAFLATAA-----FIGRPFGGALFGLLADKFGRKPLMMWSIV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 106 LMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFqyvtLISGQLIALAVLI 185
Cdd:PRK12307 92 AYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAF----LVSGFGIGNIIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 186 LLQQVLTTeqlyAWGWRIPFAIGALCAVVALYLRRGMEETESFTK---KEKAKES---------AMRTLMRHPKELMTVV 253
Cdd:PRK12307 160 YFMPSFAE----AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEaklSGKGKHSqsawsvfslSMKGLFNRAQFPLTLC 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 254 GLTMGGTL------AFYTYTTYMQKYLVNTVgmSISDSTTISAatlfLFMCLQPIIGGL-SDKIGRRPILIAFGVLGTLF 326
Cdd:PRK12307 236 VFIVLFSIfganwpIFGLLPTYLAGEGFDTG--VVSNLMTAAA----FGTVLGNIVWGLcADRIGLKKTFSIGLLMSFLF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 327 TVPILTTLHTIQSWWGA-FFLIMAALIIVSGYTSinaVVKAELFPTEIRALGVGLPYALTVSifGGTAEYIALWFKSIGM 405
Cdd:PRK12307 310 IFPLFRIPQDNYLLLGAcLFGLMATNVGVGGLVP---KFLYDYFPLEVRGLGTGLIYNLAAT--SGTFNSMAATWLGITM 384
|
...
gi 518653971 406 ETG 408
Cdd:PRK12307 385 GLG 387
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
31-380 |
1.97e-15 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 77.23 E-value: 1.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 31 GSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLnTAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFG 110
Cdd:cd17315 2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGL-VVSSLLLGAA---IGSLFGGPLADRFGRRKSLLIAAVLYVIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 111 SLLIALSPGYEIigigapilLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVlillqqV 190
Cdd:cd17315 78 ALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLL------G 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 191 LTTEQLYAWGWRIPFAIGALCAVVALYLRRGMEETEsftkkekakesamrtlmrhpkelmtvvGLTMGGTLAFYTYTT-- 268
Cdd:cd17315 144 LALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESR---------------------------ALLVGVGLQLLQQLTgi 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 269 -----YMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIigGLSDKIGRRPILI--AFGVLGTLFTVPILTTLHTIQSWW 341
Cdd:cd17315 197 navmyYAPTIFKSAGGGTASILASIIVGVVNLLATLVAI--RLVDKVGRRPLLLigFAGMAASLLLLAIAFLLPALAKAA 274
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 518653971 342 GAFFLIMAALIIVS---GYTSINAVVKAELFPTEIRALGVGL 380
Cdd:cd17315 275 GWLALLGILLYIAAfamGAGPVPWLLLSEIFPLRIRGKGMAI 316
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
33-380 |
3.84e-15 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 76.55 E-value: 3.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 33 VGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLnTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSL 112
Cdd:cd17364 6 MGFFTDAYDLFSISLVTKILGRLYYGGKGSLPSGV-SGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 113 LIALSPGYeiIGIGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRG----FYSSFQYVTLISGQLIALAVLILLQ 188
Cdd:cd17364 85 LSALSPGS--TPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGaliaAVFAMQGFGILAGAIVTLILSAIFE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 189 QVLTTEQLYA--WGWRIPFAIGALCAVVALYLRRgmeetesftkkekakesamrtlmrhpkelmTVVGLTMGGTL---AF 263
Cdd:cd17364 163 HPLPAGTYHHadLVWRIVLGLGAIPALSVLYFRK------------------------------HLLGTAGTWFLldiAF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 264 YTYTTYmQKYLVNTVGMS-----ISDSTTISAATLFLFMCL----QPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTL 334
Cdd:cd17364 213 YGQNLF-QSTIISAIGFSktmnaYQELFNIAVGQLIIALAGtvpgYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPY 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 518653971 335 HTIQSWWGAFFLIMAALIIVS--GYTSINAVVKAELFPTEIRALGVGL 380
Cdd:cd17364 292 DHWKISTIGFFVLYGLTFFFSnfGPNTTTFIVPAEVFPARVRSTCHGI 339
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
25-384 |
1.64e-14 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 75.15 E-value: 1.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 25 IKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPkGDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASV 104
Cdd:TIGR00887 15 FRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYH-GKGPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMEL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 105 YLMCFGSLLIALSPGYEIIGIGApiLLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSS----FQYVTLISGQLIA 180
Cdd:TIGR00887 94 IIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAavfaMQGFGILAGAIVA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 181 LAVLILLQQVLTTEQLYA-----------WGWRIPFAIGALCAVVALYLRRGMEETESFT-------------------- 229
Cdd:TIGR00887 172 LIVLAGFKHSLEAAADEAsctgscvpavdYMWRILIGFGAVPALLALYFRLTIPETPRYTadvakdveqaasdmsavlqv 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 230 -------KKEKAkESAMRTLMRHPKELMTVVGLTMGGTLAFYTYTTYM------------QKYLVNTVGMSISDSTTISA 290
Cdd:TIGR00887 252 kieaepdEVEKA-STAVEVPKASWSDFFTHFFKWRHGKHLLGTAGSWFlldiafygvnlnQKVILSAIGYSPPAATNNAY 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 291 ATLFLFMCLQPIIG------------GLSDKIGRRPI-LIAFGVLGTLFTVpILTTLHTIQSwwGAFFLI--MAALIIVS 355
Cdd:TIGR00887 331 EELYKTAVGNLIIAlagtvpgywvtvFLVDIIGRKPIqLMGFFILTVLFFV-LGFAYNHLST--HGFLAIyvLAQFFANF 407
|
410 420
....*....|....*....|....*....
gi 518653971 356 GYTSINAVVKAELFPTEIRALGVGLPYAL 384
Cdd:TIGR00887 408 GPNATTFIVPGEVFPTRYRSTAHGISAAS 436
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
72-390 |
4.77e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.54 E-value: 4.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 72 IFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSAT 151
Cdd:TIGR00895 57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--------TQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 152 YLSEMATKERRGFYSSFQYVTLISGQLIALAvlillqqvLTTEQLYAWGWRIPFAIGALC-AVVALYLRRGMEETESFTK 230
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGF--------LAGWLIPVFGWRSLFYVGGIApLLLLLLLMRFLPESIDFLV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 231 KEKAK-----------------ESAMRTLMRHPKELMTVVGLTMGGTLA----------------FYTYTTYMQKYLVNT 277
Cdd:TIGR00895 201 SKRPEtvrrivnaiapqmqaeaQSALPEQKSTQGTKRSVFKALFQGKTAritvllwllyfmllvgVYFLTNWLPKLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 278 vGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFgVLGTLFTVPILTTLHTIQswwGAFFLIMAALIIVSGY 357
Cdd:TIGR00895 281 -GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLL-LLGAVFAVLVGSTLFSPT---LLLLLGAIAGFFVNGG 355
|
330 340 350
....*....|....*....|....*....|....*
gi 518653971 358 TSINAVVKAELFPTEIRALGVGLPYAL--TVSIFG 390
Cdd:TIGR00895 356 QSGLYALMALFYPTAIRATGVGWAIGIgrLGAIIG 390
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
69-431 |
6.01e-14 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 73.45 E-value: 6.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 69 TAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSpgyeiIGIGAPILLVFARLLQGLSVGGEYGT 148
Cdd:cd17357 54 IVSIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLS-----KSAKSPELLIFGRFLVGIACGLSTGF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 149 SATYLSEMATKERRGFYSSFQYVTLISGqlIALAVLILLQQVLTTEQLyawgWRIPFAIGALCAVVALYLRRGMEETESF 228
Cdd:cd17357 126 VPMYLQEISPSELRGALGSLTQIGVTLG--ILLGQVFGLPSVLGTETL----WPYLLFFPGIPALLQLAALPFFPESPKF 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 229 T-----KKEKAKESAMR----------------------------TLM--------RHPKELMTVVGLT--MGGTLAFYT 265
Cdd:cd17357 200 LliskgDEEEAEKSLKFlrgieddvdqeleeikkeseqmgdqkqvSLMqllrdpslRLPLLLVLVVSASqqFSGINAIFF 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 266 YTTYMQKylvnTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSW-WGAF 344
Cdd:cd17357 280 YSTFIFE----NAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNsWMSY 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 345 FLIMAALIIVSGYT----SINAVVKAELFPTEIRALGVGLPYAL-TVSIFggTAEYIALWFKSIGMETGYYWYVTACIAV 419
Cdd:cd17357 356 GCIVAIFLFIFFFAiglgPIPWFIGAELFPQAPRSAAQSLGSSVnWTSNF--IVGMAFPPLQSIGGGFVFIIFAIPCALF 433
|
410
....*....|..
gi 518653971 420 SLMVYVTMKDTR 431
Cdd:cd17357 434 LLYLYRYLPETK 445
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
70-351 |
1.66e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.44 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 70 AAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGyeiigigaPILLVFARLLQGLSVGGEYGTS 149
Cdd:cd17477 37 ASAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 150 ATYLSEMATKERRG----FYSSFQYVTLISGQLIALAVLILLQQvltteqlyawgwriPFAIGALC---AVVALYLRRGM 222
Cdd:cd17477 106 ESWLNALATNENRGrvlgLYSTVLGLGFALGPLLLALVGTAGAL--------------PFLIAAVLlllALVPLLLTRRA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 223 EetesfTKKEKAKESAMRTLMRHPKELMT---VVGLTMGGTLAFYTYttymqkYLVNtVGMSISDSTTISAATLFLFMCL 299
Cdd:cd17477 172 A-----PEIEEAESISLRRLLRIAPLALLgafVAGFLEGAFYSLLPL------YGLR-LGLSVAQAALLLAAFVLGGLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 518653971 300 QPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAAL 351
Cdd:cd17477 240 QWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAA 291
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
81-434 |
6.91e-13 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 69.91 E-value: 6.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 81 PIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKE 160
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVW--------MLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 161 RRGFYSSFQYVTLISGQLIAlavlillqqvltteqlYAWGWRIPFAIGALCAVVAL----------------YLRRGMEE 224
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLG----------------YVLGSFLPWRTLALIGAIPPvvflillffipesprwLAKKGREE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 225 -----------------------TESFTKKEKAKESAMRTLMRHP---KELMTVVGLT----MGGTLAFYTYTTYMQKYL 274
Cdd:cd17358 191 eaekslqflrgkdadiskeaaeiQEELAELEKEAKESSFSDLFQRkylKPLVIGLGLMlfqqLSGINAVIFYASSIFDEA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 275 VNTVgmsisdSTTISAATLFLFMCLQPIIG-GLSDKIGRRPILIAFGV--------LGTLFTVPILTTLHTIQSWWgAFF 345
Cdd:cd17358 271 GSGL------DPNTATIIIGVVQVVGTLVAtLLVDRLGRRPLLLVSAIgmgigllaLGLYFYLQEHGALLSSVSWL-PLV 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 346 LIMAALIIVS-GYTSINAVVKAELFPTEIRALGVGLpyALTVSIFGGTAeyIALWFKSIGME---TGYYW-YVTACIAVS 420
Cdd:cd17358 344 GLVIYIISFSiGLGPLPWVIMSEIFPAKIKGLAGSL--VTLVNWLFAFI--VTKTFPFLTLAwgaSGTFWiFAGICGLAL 419
|
410
....*....|....
gi 518653971 421 LMVYVTMKDTRKHS 434
Cdd:cd17358 420 VFVLLFVPETKGKS 433
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
62-346 |
3.43e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.49 E-value: 3.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 62 TTAQLLNTAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQGLS 141
Cdd:COG0738 41 SDAQAGLLLFAFFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 142 VGGEYGTSATYLSEMATKERRGFYSSFQYV----TLISGQLIALAVLILLqqvltteqlyAWGWRIPF-AIGALCAVVAL 216
Cdd:COG0738 110 LGLLDVAANPYVAALGPETAASRLNLLHAFfslgALLGPLLGGLLILLGL----------SLSWHLPYlILAVLLLLLAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 217 YL-RRGMEETESFTKKEKAKESAMRTLMRHPKELMTVVGLtMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFL 295
Cdd:COG0738 180 LFlRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAI-FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGG 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 518653971 296 FMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAFFL 346
Cdd:COG0738 259 MTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
86-424 |
6.59e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 63.34 E-value: 6.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 86 LMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigaPILLVFArLLQGLSVGGEYGTSATYLSeMATKERRGFY 165
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-------WLLLLLV-ALAGIGSAAFHPEGARLAS-QAAGGRRGLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 166 SSFQYVTLISGQLIALAVLillqqVLTTEQLYAWGWRIPFAIGALcaVVALYLRRGMEETESFTKKEKAKESAMRTLMRH 245
Cdd:cd17478 121 MSIFSVGGNLGFALGPLIA-----AALVALFGGLGLLILLIIPGL--AVALLLLRLRPLKKPEAKKAAAKSSARSTLKGV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 246 PKELMTVVGLTMGGTLAFYTYTTYMQKYLVnTVGMSISDSTTIsaATLFLFMCL--QPIIGGLSDKIGRRPILIAFGVLG 323
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAGLL--LSLFLFAGAigTLIGGPLSDRFGRRRVIIASLLLA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 324 TLFTVPILTTlhtiQSWWgAFFLIMAALIIVSGYTSINAVVKAELFPtEIRALGVGLPYALTVSIFGGTAEYIALWFKSI 403
Cdd:cd17478 271 APFLLLFLLT----PGIW-SYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAF 344
|
330 340
....*....|....*....|.
gi 518653971 404 GMETGYYWYVTACIAVSLMVY 424
Cdd:cd17478 345 GLESVLLILALLPLLGALLAF 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
53-391 |
8.12e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 8.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 53 AKAFFPKGDTTAQLLNTA-AIFAVGFLmrPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLL 131
Cdd:cd17473 26 AQHFVPNSELLVPLLLTLpALFIALFA--PLAGWL----ADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--------AL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 132 VFARLLQGLSVGGEYGTSATYLSEMATKERR----GFYSSFQYV-----TLISGqlialavlillqqvltteQLYAWGWR 202
Cdd:cd17473 92 LASRALLGIGVAGIMTLATALIGDYFEGEERakmlGLQSAAMSLggvvfLLLGG------------------ALAEIGWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 203 IPFAIGALCAVVALYLRRGMEETESfTKKEKAKESAMRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNT-VGMS 281
Cdd:cd17473 154 APFLVYLLALPVLILVLLFLPEPAR-KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERgGGSA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 282 ISDSTTISAATLFlfmclQPIIGGLSDKIGRRpiliaFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAALIIVSG----- 356
Cdd:cd17473 233 ALIGLALAIASLA-----GAIGALLFGRLKRR-----LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGlgfgl 302
|
330 340 350
....*....|....*....|....*....|....*.
gi 518653971 357 -YTSINAVVkAELFPTEIRALGVGLpyaLTVSIFGG 391
Cdd:cd17473 303 lLPTLNSWA-MSLVPPELRGRAMGI---VTSAFFLG 334
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
88-431 |
1.82e-10 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 62.37 E-value: 1.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 88 GLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSS 167
Cdd:cd17362 60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 168 FQYVTLISGQLIALAVLILLQQVLtteqlyaWGWRIPFAIGAlcaVVALYLRRGMEETESFTKKEKAkesamrtlMRHPk 247
Cdd:cd17362 132 LKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAA---PPALLLGIGMWFLPPSPRWQGN--------YRKP- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 248 elmtvvgLTMGGTLAFYTYTT------YMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIG-GLSDKIGRRPILIA-- 318
Cdd:cd17362 193 -------LIIGLGLVLFQQITgqpsvlYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAvLLVDKLGRRPLLLGgv 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 319 FGVLGTLFTVPILTTLHTIQSWWGAFFLIMAALIIVSGYT----SINAVVKAELFPTEIRALGVglpyALTVSIFGGTAE 394
Cdd:cd17362 266 SGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQisfgPISWLMVSEIFPLRVRGRAI----ALAVLVNFGSNA 341
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 518653971 395 YIALWF----KSIGMETGYYWYVTACIAVSLMVYVTMKDTR 431
Cdd:cd17362 342 LVSLAFlplqELIGLPGTFLGFGVIGVLALLFIYFTVPETK 382
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
40-377 |
2.54e-10 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 62.36 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 40 YDWYVYAAF--SLYFAKAFFP---KGDTTAQLLNTAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLI 114
Cdd:TIGR00879 42 YDTGVIGGAlaLPAFEFKFTSansDSYSSSLWGLVVSIFLVGGF---IGALFAGWLSDRFGRKKSLLIIALLFVIGAILM 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 115 ALSPGYEIIGigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLillqqVLTTE 194
Cdd:TIGR00879 119 GLAAFALSVE-----MLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFG-----SGKVS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 195 QLYAWGWRIPFA---IGA---LCAVVAL------YLRRGMEE-----------TESFTKKEKAKESAMRTLMRHPKE--- 248
Cdd:TIGR00879 189 LNNTLGWRIPLGlqlIPAgllFLGLFFLpesprwLVGKGRVEearkslarlrgTSGEDKELLDELELIDIKRSIEKRsvq 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 249 ----------------LMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGR 312
Cdd:TIGR00879 269 pswgslfsstrrirrrLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGR 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518653971 313 RPILIaFGVLGTLFTVPILTTLHTIQSW-------WGAFFLIMAALIIVS-GYTSINAVVKAELFPTEIRALG 377
Cdd:TIGR00879 349 RPLLL-IGAAGMAICLFVLGILGASFVTgsskssgNVAIVFILLFIAFFAmGWGPVPWVIVSEIFPLSLRPKG 420
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
75-364 |
4.24e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.46 E-value: 4.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 75 VGFLMRPIGGWLMGLYADKVGRKKA-LMASVYLMCFGSLLIALSPGYEiiGIGAPILLVFARLLQGLSVGGEYGTSATYL 153
Cdd:COG2211 58 WDAITDPLIGALSDRTRTRWGRRRPwILIGAIPLALSFVLLFTAPDLS--PTGKLIYALVTYLLLGLAYTLVNIPYSALG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 154 SEMAT-KERRGFYSSFQYVTLISGQLIALAVLILLQQVLTTEQlyAWGWRIPFAIGALCAVVALYL-RRGMEETESFTKK 231
Cdd:COG2211 136 AELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLLtFFGTKERPVPEEE 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 232 EKAKESAMRTLMRHpKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIG 311
Cdd:COG2211 214 KVSLKESLKALLKN-RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 518653971 312 RRPILIAFGVLGTLFTVpILTTLHTIQSWWGAFFLIMAALIIVSGYTSINAVV 364
Cdd:COG2211 293 KKKAFIIGLLLAALGLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAML 344
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
40-380 |
8.14e-10 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 59.98 E-value: 8.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 40 YDWYVYAAFSLYFAKAFFPKGDTTA-QLLNTAAIFAVGFLMRPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSP 118
Cdd:cd17360 11 YDTGVISGALLYIKDDLGEVVLSTGwQELIVSSTVAGAAVGAAIGGWL----NDRFGRRPCILLADALFTIGAIVMAAAP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 119 GYEIIGIGapillvfaRLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLILLQQVLTteqlya 198
Cdd:cd17360 87 NKEVLIVG--------RVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPG------ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 199 wGWRIPFAIGALCAVVALYLRRGMEETESFTKKEKAkesamrtlmrhpkeLMTVVGLTMGGTLA-----FYTYTTYMQKY 273
Cdd:cd17360 153 -GWRWMLGLAAVPAVLQFIGLLFLPESPRWPSTRRA--------------LIVGCGLQAFQQFSgintvMYYSATILQMA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 274 LVNTVGMSISDStTISAATLFLFmclqPIIG-GLSDKIGRRPILIaFGVLGTLFTVPILTtlhtiqSWWGAFFLIMAALI 352
Cdd:cd17360 218 GFKDNQNAIWLS-LIVAGTNFIF----TIVGmYLIDKFGRRKLLL-ISLFGVIVALVVLA------VWLALVGLILYLAF 285
|
330 340
....*....|....*....|....*...
gi 518653971 353 IVSGYTSINAVVKAELFPTEIRALGVGL 380
Cdd:cd17360 286 FAPGMGPVPWTVNSEIYPLWARGTGGGC 313
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
62-427 |
9.97e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.89 E-value: 9.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 62 TTAQLLNTAAIFAVG-FLMRPIGGWLMglyaDKVGRKKALMASVYLMCFGSLLIALspgyeiigIGAPILLVFARLLQGL 140
Cdd:cd17319 36 SPTQYGLIASAFFLGyALFQVPGGWLL----DRFGARKVLAVSMLLWSLFTALTGF--------ATSLTSLYVLRFLLGV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 141 SVGGEYGTSATYLSEMATKERRGFYSSFqyvtLISGQLIALAVLILLQQVLTTeqlyAWGWRIPFAIGALCAVVALYLrr 220
Cdd:cd17319 104 AEAGFFPGAIKALAEWFPARERGRATGL----FNSGAPLGAAIGPPLSGWLLL----LFGWRWAFIIEGLLGLLLAVL-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 221 gmeetesftkkekakesamrTLMRHPKELMTVVGlTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATlFLFMCLQ 300
Cdd:cd17319 174 --------------------WWFYLRQVWGLALG-YFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIP-FLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 301 PIIGG-LSDKI--GRRPILIAFGVLgtLFTVPILTTLHTIQSWWGAFFLIMAALIIVSGYTSINAVVkAELFPTEIRALG 377
Cdd:cd17319 232 MILGGrLSDRLlrGARRLVIIIGLL--LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLP-ADLLPGEAAATA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 518653971 378 VGLpYALTVSIFGGTAEYIALWFKSI-GMETGYYWYVTACIAVSLMVYVTM 427
Cdd:cd17319 309 GGL-INSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
47-435 |
4.79e-09 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 58.03 E-value: 4.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 47 AFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMrpiGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSpgyeiigIG 126
Cdd:cd17356 28 SFQKYFADNTGTYYPSSSRQGLIVSIVNLGSFF---GALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAA-------IG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 127 APILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLILLQQVLTTEQlyawgWRIPFA 206
Cdd:cd17356 98 KWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQ-----WRIPLG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 207 IGALCAVVALYLRRGMEETESFTKKekakesamrtlmrhpkeLMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDST 286
Cdd:cd17356 173 LQIVWGLLLLIGMFFLPESPRWLYR-----------------TILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 287 TISAATLFLFMCLQPIIGGLSDKIGRRPILI--AFGVLGTLFTVPILTTLHTIQSWW--------GAFFLIMAALIIVS- 355
Cdd:cd17356 236 LTSIILYIVNFVSTIPGLFFVDKFGRRTCLLigAAGMSICLFIYAAVGVRYLIPNPQsgtsnksaGNGMIVFICLFIFSf 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 356 --GYTSINAVVKAELFPTEIRALGVGLpyALTVSIFGGTAeyIALW----FKSIGMETGYYWYVTaCIAVSLMVYVTMKD 429
Cdd:cd17356 316 atTWGPIAWVYVAEVFPLRVRSKGMAL--ATAFNWLWNFL--ISFFtpfiIGSIGFKYYYIFAGC-NLLAFIVVFFFVPE 390
|
....*.
gi 518653971 430 TRKHSR 435
Cdd:cd17356 391 TKGLTL 396
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
82-425 |
5.71e-09 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 57.80 E-value: 5.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEIIGIGapillvfaRLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVG--------RFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 162 RGFYSSFQYVTLISGQLIALAVLILLQQVltTEQLyawGWRIPFAIGALCAVVALYLRRGMEETESFTkkekakeSAMRt 241
Cdd:cd17437 119 RGFLTSFPEIFINIGILLGYVSNYAFSGL--PLHV---GWRLMLGVGAVPSLFLAIGVLAMPESPRWT-------PAVR- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 242 lmrhpKELMTVVGLTM----GGTLAFYTYT---------TYMQKYLVNTVGMSISDSTTISAATLFLfmclqpiigglsD 308
Cdd:cd17437 186 -----RMLIAALGIHFfqqaSGIDAVVLYSprifkkagiKSKDKLLLATVAVGVTKTLFILVATFLL------------D 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 309 KIGRRPILIAfGVLGTLFTVPILTTLHTI------QSWWGAFFLIMAALIIVS----GYTSINAVVKAELFPTEIRALGV 378
Cdd:cd17437 249 KVGRRPLLLT-STGGMTLSLTALATSLTFidrnggGLTWALVLAITAVCSFVAffsiGAGPITWVYSSEIFPLRLRAQGA 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 518653971 379 GLPYALTvSIFGGTaeyIALWFKSI--GMETGYYWYVTACIAVSLMVYV 425
Cdd:cd17437 328 SLGVVVN-RLMSGT---VSMTFLSMskAITTGGTFFLFAGVAAAAWVFF 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
66-427 |
1.36e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.42 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 66 LLNTAAIFAVGFLMrPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGE 145
Cdd:cd17474 38 LLITAFTLPAAVLM-PVAGVL----ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 146 YGTSATYLSEMATKERR----GFYSSFQYVTLISGQLIALAvlillqqvltteqLYAWGWRIPFAI-GALCAVVALYLRR 220
Cdd:cd17474 105 GPLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLGGL-------------LAAISWRYPFFLlAALIPVAFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 221 GMEETESFTKKEKAKESAMRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQ 300
Cdd:cd17474 172 LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 301 PIIGGLSDKigrrpiliAFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAALIIVSGY------TSINAVVkAELFPTEIR 374
Cdd:cd17474 252 LFVGRLLKK--------RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLglglnlPLLTTLV-TELAPEEER 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 518653971 375 ALGVGLpYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIAVSLMVYVTM 427
Cdd:cd17474 323 GTASSL-YNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
62-351 |
4.60e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 54.89 E-value: 4.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 62 TTAQLLNTAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLS 141
Cdd:cd17320 32 SASAVQLTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE--------QLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 142 VGGEYGTSATYLSEM-ATKERRGFYSSFQYVTLIS-------GQLIalavlillqqvltteqLYAWGWRIPFAI-GALCA 212
Cdd:cd17320 101 AAAGSVVARAIVRDLySGAELAKIFSLLMMILAIApalapllGGLL----------------LLFFGWRAIFVFlALLGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 213 VVALYLRRGMEET---ESFTKKEKAKESAMRTLMRHPKEL--MTVVGLTMGGTLAFYTYTTYMqkyLVNTVGMSISDSTT 287
Cdd:cd17320 165 LLLLLVLLFLPETlpeEKRKPLLSSLLRAYKRVLKNRRFLgyALALGLSFAGLFAYLAAAPFI---YIEQLGLSPAQFGL 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518653971 288 ISAATLFLFMCLQPIIGGLSDKIGRRPIL----IAFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAAL 351
Cdd:cd17320 242 LFALNAIALILGSLLNGRLVRRFGPRRLLrlglLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGF 309
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-352 |
1.07e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.75 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 69 TAAIFAVGFLMRPIGGWLMglyaDKVGRKKALMASVYLMCFGSLLIALSPGyeiigigaPILLVFARLLQGLSVGGEYGT 148
Cdd:cd17489 37 VGLFTLAALLARPFAGRLL----DRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 149 SATYLSEMATKERRG----FYSSFQYVTLISGQLIALAVLIllqqvltteqlyAWGWRIPFAIGALCAVVALYLRRGMEE 224
Cdd:cd17489 105 AATLVADIIPPSRRGegigYYGLATTLAMALGPALGLFLYQ------------HLGFAVLFIVAAVLALLALLLVFLVKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 225 TESFTKKEKAKESAMRTLMRHPKEL-----MTVVGLTMGGTLAFytYTTYMQKYLVNTVGMSIsdstTISAATLFLFmcl 299
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLppaliLFLASIAYGAISTF--LPLYAAERGISNAGLFF----TVYAIALLLS--- 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 518653971 300 QPIIGGLSDKIGRRPILIAFGVLGTLFtvpiLTTLHTIQSWWgaFFLIMAALI 352
Cdd:cd17489 244 RPFSGKLSDRKGPKTVIIPGLLLLALG----LLLLSFAGSPW--MLLLAAVLY 290
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
69-380 |
1.31e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 52.97 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 69 TAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGT 148
Cdd:cd17317 30 VQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 149 SATYLSEMATKERRGFYSSFQYVTLISGQLIALAVLILLQQvltteqlyawgWR-IPFAIGALCAVVALYLRrgmeetes 227
Cdd:cd17317 99 GFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD-----------WRwLQLAISLPGLLFLLLLW-------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 228 FTkkekakesAMRTLMrhpkelMTVVGLTMggTLAFYTYTTYM-----QKYLvNTVGMSISDSTTISAATLFLfmclqpi 302
Cdd:cd17317 160 WL--------PRRTII------VGLIWFVT--SLVYYGLSLNSsnlggNLYL-NFFLSGLVEIPAYFLALLLL------- 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518653971 303 igglsDKIGRRPILIAFGVLGTLFTVPILtTLHTIQSWWGAFFLIMAALIIVSGYTSINaVVKAELFPTEIRALGVGL 380
Cdd:cd17317 216 -----DRLGRRWTLSGSLLLAGLACLVTA-LLPDDENTLALTLALVGKFAISAAFSVIY-LYTAELYPTVVRNTGVGL 286
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
71-351 |
5.31e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 5.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 71 AIFAVGFLMrpiggwLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGyeiigigaPILLVFARLLQGLSVGGEYGTSA 150
Cdd:cd17321 41 LLAFAALLL------LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 151 TYLSEMATKERR----GFYSSFQYVTLISGQLIALavlillqqVLTTeqlyAWGWRIPFAIGALCAVVALYLRRGmeete 226
Cdd:cd17321 107 ALIAATFPGERRgralGLWGAVVGIGAALGPLLGG--------LLLE----LFGWRWIFLINVPIGLVALLLART----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 227 sFTkkekakesamrtlmrhpkeLMTVVGLTMGGtlAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGL 306
Cdd:cd17321 170 -FS-------------------GAVLAAFLLGA--ALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 518653971 307 SDKIGRRPILIAFGVLGTLFTVPILTTLHTiqSWWGAFFLIMAAL 351
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLALLGAD--SSVWLLLPGLVLL 270
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
52-380 |
1.19e-06 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 50.33 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 52 FAKAFFP------KGDTTA-------QLLN--TAAIFAVGFLMRPIGGWLMGLYadkvGRKKALMASVYLMCFGSLLIAL 116
Cdd:cd17361 25 FLEKFFPsvyekkKGASENnyckyddQLLQlfTSSLYLAGLVASLLASYVTRKW----GRKPSMLIGGVLFLVGAALNAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 117 SPGYEIIGIGapillvfaRLLQGLSVGGEYGTSATYLSEMA-TKERRGFYSSFQYVTLISgqlialavlILLQQVLT--T 193
Cdd:cd17361 101 AQNIAMLIVG--------RILLGFGVGFGNQAVPLYLSEMApAKLRGALNIGFQLAITIG---------ILIANLINygT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 194 EQLYAWGWRIPFAIGALCAVVALYLRRGMEETESFtkkekakesamrtlmrhPKELMTVVG-----LTMGGTLAFYTytt 268
Cdd:cd17361 164 SKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNS-----------------PQLVIAILIpffqqLTGINVIMFYA--- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 269 ymqKYLVNTVGMSiSDSTTISAATLFLFMCLQPIIG-GLSDKIGRRPILIAFGVLGTLFTVPILTTLH-------TIQSW 340
Cdd:cd17361 224 ---PVLFQTLGFG-SDASLISAVITGAVNVVSTLVSiYLVDRFGRRFLLLEGGVQMLASQVAIGILLAvkfgdggELPKA 299
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 518653971 341 WGAFFLIMAALIIVS---GYTSINAVVKAELFPTEIRALGVGL 380
Cdd:cd17361 300 YAIAVVVLICLYVAAfawSWGPLGWLVPSEIFPLETRSAGQSL 342
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
68-380 |
2.88e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 49.24 E-value: 2.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 68 NTAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigaPILLVFaRLLQGLSVGGEYG 147
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY-------TVFLVF-RLLVGMGIGGIWV 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 148 TSATYLSEMATKERRGFYSSFQYVTLISGQLIalavlillqqvlttEQLYAW---GWR-------IPFAIGA-LCAVVA- 215
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVL--------------LPLVAYfipDWRwlqlavsLPTFLFFlLSWFVPe 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 216 ----LYLRRGMEETESFTKK-----------------------EKAKESAMRTLMRHPKELMTVVGLTMGGTLAFYTYtt 268
Cdd:TIGR00898 266 sprwLISQGRIEEALKILQRiakingkklpaevlslslekdlsSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSY-- 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 269 YMQKYLVNTVGMSISDSTTISAATLF--LFMCLQPIigglsDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAffL 346
Cdd:TIGR00898 344 YGLVLDLGNLGGNIYLDLFISGLVELpaKLITLLLI-----DRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTA--L 416
|
330 340 350
....*....|....*....|....*....|....
gi 518653971 347 IMAALIIVSGYTSINAVVKAELFPTEIRALGVGL 380
Cdd:TIGR00898 417 AVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGV 450
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
82-168 |
5.39e-06 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 48.82 E-value: 5.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:TIGR01299 217 VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYG--------FFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEK 288
|
....*..
gi 518653971 162 RGFYSSF 168
Cdd:TIGR01299 289 RGEHLSW 295
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
206-364 |
9.18e-06 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 47.50 E-value: 9.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 206 AIGALCAVVALYLRRGMEETESfTKKEKAKE--SAMRTLMRHPKELMTVVgLTMGGTLAFYTYTTYMQKYLVNTVGMSIS 283
Cdd:cd17337 167 ALGGLIALFLVRDRTGEQPLAN-PSEEPLKEllSGITILFRNPKIAIGGI-VRIINTLSQFGFPVFMPLYFTDTGGFSTS 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 284 DSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPIlttLHTIQSWWGAFFLIMAAL-----IIVSGYT 358
Cdd:cd17337 245 QWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLL---FYYVPQLFGHNYWAALIAailfgIGLAGFV 321
|
....*.
gi 518653971 359 SINAVV 364
Cdd:cd17337 322 PLSALM 327
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
69-425 |
1.12e-05 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 47.61 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 69 TAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSpgyEIIGigAPILLVFARLLQGLSVGGEYGT 148
Cdd:cd17432 55 TVSIFPLGGL---FGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLS---KIAK--SFEMIIVGRFLVGINAGISLNV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 149 SATYLSEMATKERRGFY----SSFQYVTLISGQlialavLILLQQVLTTEQlyawGWRIPFAIGALCAVVAL-------- 216
Cdd:cd17432 127 VPMYLGESAPKNLRGAVglvpAIFITLGILLGQ------VLGLRELLGNEE----GWPLLLALTGVPALLQLltlpffpe 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 217 ---YLR----------------RG-------MEETESFTKKEKAKES-AMRTLMRHPK---ELMTVVGLTMG----GTLA 262
Cdd:cd17432 197 sprYLLiekgdeeaarkalqrlRGkedvddeMEEMLEEQRAEKGVGTvSVLELFRDRSvrwQLISIIVLMAGqqlcGINA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 263 FYTYTTYMqkYLVNTVGMSISDSTTISAATLFLFMCLqpIIGGLSDKIGRRPILIA-FGVLGTLFTVPILTTLHTIQSWW 341
Cdd:cd17432 277 IYFYADSI--FLEAGIPEDKIQYVTVGTGACEVLATI--TCVLVIERLGRRPLLIGgFGLMAVWCAVLTVALSLQNTVSW 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 342 GAFFLIMAALIIVSGYTS----INAVVKAELFPTEIRalgvglPYALTVsifGGTAEYIALW-----FKSIGMETGYYWY 412
Cdd:cd17432 353 MPYLSIVCIFAYIASFGIgpagVPFILTTEIFDQSSR------PAAFMV---AGSLNWLSNFlvgllFPFIQEGLGAYCF 423
|
410
....*....|....
gi 518653971 413 VT-ACIAVSLMVYV 425
Cdd:cd17432 424 LVfAVICLLTAIYI 437
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
82-163 |
1.33e-05 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 47.10 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17363 49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYG--------FFLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
|
..
gi 518653971 162 RG 163
Cdd:cd17363 121 RG 122
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
82-168 |
2.61e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 46.44 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17440 49 VGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYG--------LFLFCRLLSGFGIGGAVPTVFSYFAEVLAREK 120
|
....*..
gi 518653971 162 RGFYSSF 168
Cdd:cd17440 121 RGEHLSW 127
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
62-348 |
2.79e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 62 TTAQLLNTAAIFAVGfLMRPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGYEIigigapilLVFARLLQGLS 141
Cdd:cd17503 31 DTVQWVITSYLLALA-IMIPLSGWL----ADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 142 VGGEYGTSATYLSEMATKERRGFYSSFQYVTLISGQLIAlavlillqQVLTTEQLYAWGWRIPF----AIGALCAVVALY 217
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIG--------PTLGGWLTDNLSWRWIFyinlPIGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 218 LRRGMEETESFTKkekakeSAMrtlmrhpkeLMTVVGLTMGGTlaFYTYTTYMQkylvNTVGMSISDSTTISAATLFLFM 297
Cdd:cd17503 170 LDLRLFKDRNFTL------GLL---------LSFLLGLGLFGA--MFLLPLYLQ----NVLGYSAFESGLVLAPGGLASA 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 518653971 298 CLQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAFFLIM 348
Cdd:cd17503 229 ILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFI 279
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
62-364 |
6.32e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.86 E-value: 6.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 62 TTAQLLNTAAIFavgflmrPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGyeiigigaPILLVFARLLQGLS 141
Cdd:cd17502 36 GTAYLLTSTAFQ-------PIYGKL----SDLFGRKWVLLIAIVIFELGSLLCGLAPN--------MTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 142 VGGEYGTSATYLSEMATKERRGFYSSFQYVT---------LISGqlialavlillqqVLTTEqlyaWGWRIPFAIGALCA 212
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRERGKYQGYIGAVfgiasvagpLIGG-------------AFTDH----LSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 213 VVALYLRRGMeetesftkkekakesamrtlmrhpkELMTVVGLTMGGtlAFYTYTTYMQKYLVNTVGMSISDSTTISAAT 292
Cdd:cd17502 160 GLALALLRTI-------------------------LLSSIFGFLFGG--ALFGLIYYLPLYFQLVLGDSATKSGVRLLPL 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518653971 293 LFLFMCLQPIIGGLSDKIGR-RPILIAFGVLGTLFTVPILTTLHTIQSWWGAFFLIMAALIIVSGYTSINAVV 364
Cdd:cd17502 213 IIGLVIGSIISGALISKTGRyKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAV 285
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
60-346 |
6.55e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.86 E-value: 6.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 60 GDTTAQLLNTAAIFAVGFLMrPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQG 139
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFA-PLAPRL----ARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 140 LSVGGEYGTSATYLSEMAtKERRGFYSSFQYVTLISGQLIALAVLILLQQvltteqlyAWGWRIPFAIGALCAVVALYLR 219
Cdd:COG2807 118 AGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAA--------ALGWRGALAVWALLALLALLLW 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 220 RGMEETESFTKKEKAKESAMRTLMRHPkeLMTVVGLTMGG-TLAFYTYTTYMQKYLVNTvGMSISDSTTISAATLFLFMC 298
Cdd:COG2807 189 LPLLRRRPAAAAAAPAAASLRSLWRSP--LAWLLTLFFGLqSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIP 265
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 518653971 299 LQPIIGGLSDKIGRRPILIAFGVLGTLFTVPILTTLHTIQSWWGAFFL 346
Cdd:COG2807 266 GSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL 313
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
82-170 |
7.37e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.95 E-value: 7.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:PRK11551 69 LGGRL----ADRIGRKRILIVSVALFGLFSLATAQAWDFP--------SLLVARLLTGVGLGGALPNLIALTSEAVGPRL 136
|
....*....
gi 518653971 162 RGFYSSFQY 170
Cdd:PRK11551 137 RGTAVSLMY 145
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
75-331 |
8.49e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 8.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 75 VGFLMRPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGyeiigigaPILLVFARLLQGLSVGGEYGTSATYLS 154
Cdd:cd17329 47 AGIVASLIGGRL----ADRFGRKPVMLAGLLLRALGFALLGFAHS--------PWLFAIALVLTGFGGGLFEPASEAMIA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 155 EMATKERRGFYSSFQYVTLISGQLIALAVLILlqqvltteqLYAWGWRIPFAIGALCAVVA---LYLRRGMEETESFTKK 231
Cdd:cd17329 115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGL---------LLLYSFRLLFLAAAVLFLLAalvLLFLLPETRPKRRAAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 232 EKAKESAMRTLMRHpKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIGGLSDKIG 311
Cdd:cd17329 186 KTEILRGYKIVLRD-RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260
....*....|....*....|
gi 518653971 312 RRPILIAFGVLGTLFTVPIL 331
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLA 284
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
82-228 |
1.03e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 44.53 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEiigigapiLLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518653971 162 RGFYSSFQYVTLISGQLIALAVlillqqVLTTEQLYAWG-----------WRIPFAIGALCAVVALYLRRGMEETESF 228
Cdd:cd17438 121 RGEHLSWLCMFWMIGGLYASAM------AWSIIPHYGWGfsmgtnyhfhsWRVFVIICALPCIASIIALKFMPESPRF 192
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
69-162 |
1.25e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 43.88 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 69 TAAIFAVGFLmrpIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigaPILLVFaRLLQGLSVGGEYGT 148
Cdd:cd17379 38 FQSSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY-------PWFLIF-RFLQGLFGKGGWMT 106
|
90
....*....|....
gi 518653971 149 SATYLSEMATKERR 162
Cdd:cd17379 107 GYVLVTEFVGSKYR 120
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
73-330 |
1.96e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 73 FAVGFLMRPIGGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGYEIigigapilLVFARLLQGLsVGGEYGTSATY 152
Cdd:cd17391 46 FLVSAIFSPIWGRL----ADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGV-FSGYVPNATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 153 LSEMATKERRGFYSSfqyvTLISGQLIALAVLILLQQVLttEQLYawGWRIPFAIGA----LCAVVALYLRRgmeetESF 228
Cdd:cd17391 113 IASQTPKEKSGWALG----TLSTGVVAGTLIGPLLGGFL--ADLF--GIRNVFFITGgllfLAFLLTLFFVK-----EDF 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 229 TKKEKAKESAMRTLMR---HPKELMTVVGLTMGGTLAFYTYTTYMQKYlVNTVGMSISDSTTIS----AATLFLFMCLQP 301
Cdd:cd17391 180 KPVEKKKMVSTKEVWNsvpNPSLLISLFVTTFIIQLANQSIEPILTLY-IRQLMGDASNLAFISglvfSATGVSSLLSAP 258
|
250 260
....*....|....*....|....*....
gi 518653971 302 IIGGLSDKIGRRPILIAFGVLGTLFTVPI 330
Cdd:cd17391 259 RLGKLGDRIGHHRILLGALLASALLYIPQ 287
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
82-434 |
4.40e-04 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 42.10 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMglyaDKVGRKKALMASVYLMCFGSLLIALSpgyeiigiGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17436 55 IGGFLI----DRHGRRTSILGSNLVLLAGSLILTLA--------GSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 162 RGFYSSFQYVTLISGQLIALAVLILLQQVltteqlyAWGWRIPFAIGALCAVVALYlrrgmeetESFTKKEKAKESAMRT 241
Cdd:cd17436 123 RGLLVSLYEAGITVGILISYALNYFFSNV-------LTGWRYMFGLAIIPAAIQFA--------SILLLPKKPEVLNIKD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 242 LMRHpkelMTVVGLtmgGTLAFYTYT-----TYMQKYLVNTVGMSISDSTTISAATLFLFMCLQPIIG-GLSDKIGRRPI 315
Cdd:cd17436 188 NMRR----RTLVGL---GLVLFQQFTgqpnvLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAmLFADRAGRRSL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 316 LIAFGVLGTLFTVPIlttlhtiqSWWGAFFLIMAALIIVS-GYTSINAVVKAELFPTEIRalgvGLPYALTVSIFGGTAE 394
Cdd:cd17436 261 LIAGCSVMAVSVSGI--------GLWITLLCLMAFVSAFSiGFGPMTWLVLSEIYPADIR----GRAFSFCNSFNWAANL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 518653971 395 YIALWF----KSIGMETGYYWYVTACIAVSLMVYVTMKDTRKHS 434
Cdd:cd17436 329 LITLSFldliDVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQS 372
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
82-218 |
5.56e-04 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 41.99 E-value: 5.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMcFGSLLIALSPGYEIIGIGAP-----ILLVFARLLQGLSVGGEYGTSATYLSEM 156
Cdd:PRK10077 70 IGGALGGYCSNRFGRRDSLKIAAVLF-FISALGSAWPEFGFTSIGPDntgyvPEFVIYRIIGGIGVGLASMLSPMYIAEI 148
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518653971 157 ATKERRGFYSSFQYVTLISGQLIALAVLILLQQVLTTEQLYAWGWRIPFAIGALCAVVALYL 218
Cdd:PRK10077 149 APAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARSGDASWLNTDGWRYMFASEAIPALLFLML 210
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-168 |
6.52e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 6.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 3 NSNTVPLGSTAAKAQERTTSSRIKSIFSGSVGNMVEWYdwYVYAAFSLYfAKAFFPKGDTTAQLLNTAAiFAVGFLMRPI 82
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG--ALEPFLPLY-AAELGGLSPAQIGLLFGAQ-GLASALSQPP 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 83 GGWLmglyADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSATYLSEMATKERR 162
Cdd:cd17325 255 AGKL----SDRIGRKPLILIGLLLSAVALLLLPLATSF--------WLLLLLLALLGLGLGLVFPATLALLADIVPPEGR 322
|
....*.
gi 518653971 163 GFYSSF 168
Cdd:cd17325 323 GTAMGL 328
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
82-168 |
1.26e-03 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 41.17 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 82 IGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYEIigigapilLVFARLLQGLSVGGEYGTSATYLSEMATKER 161
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
....*..
gi 518653971 162 RGFYSSF 168
Cdd:cd17439 121 RGEHLSW 127
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
289-361 |
2.07e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 40.31 E-value: 2.07e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518653971 289 SAATLFLF--MCLQPIIGGLSDKIGRRPILIaFGVLgtLFTVPILTTL--HTIQSWWGAFFL--IMAALIIVSGYTSIN 361
Cdd:PRK15402 52 TSMTAYLAggMFLQWLLGPLSDRIGRRPVML-AGVA--FFILTCLAILlaQSIEQFTLLRFLqgIGLCFIGAVGYAAIQ 127
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
249-380 |
3.67e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 249 LMTVVGLTMGGTLAFYTYTTYMQKYLVNTvGMSISDSTTISAATLFLFMCLQPIIGGLSDKIGRRPILIAfGVLGTLFTV 328
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKL-GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL-SLAGSAVSY 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 518653971 329 PILTTLHTIqswwgaFFLIMAALI--IVSGYTSINAVVKAELFPTEIRALGVGL 380
Cdd:cd17330 79 VLLGLSRNL------WLLFLARFLdgLTGGNVSVAQAYIADITDEEERAKAFGI 126
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
41-141 |
3.93e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 39.12 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 41 DW----YVYAAFSLYFakafFPKGDTtaqllntAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIaL 116
Cdd:cd17487 19 DWlqgpYLYALYESYG----FSEEQI-------AILFVTGFGSSVVFGTFVGSLADKFGRKRACLLFCVLYSLSCLTK-H 86
|
90 100
....*....|....*....|....*
gi 518653971 117 SPGYEIigigapilLVFARLLQGLS 141
Cdd:cd17487 87 SPNFGV--------LLLGRVLGGIS 103
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
77-427 |
5.15e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 39.01 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 77 FLMRPIGGWLMGLYadkvGRKKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTSATYLSEM 156
Cdd:cd17435 50 LLASLTGGVLIDRY----GRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAEI 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 157 ATKERRGFYSSFQYVTLISGQLIALAVLILLQQVLTteqlyawGWRIPFAI----GALCAVVALYLRRgmeetesfTKKE 232
Cdd:cd17435 118 APQHRRGLLVSLNELMIVIGILLAYISNYAFANVSN-------GWKYMFGLviplAALQAIAMYFLPP--------SPRF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 233 KAKESAMRTLMRHPKELMTVVGLTMGGTLAFYTYTtymqkyLVNTVGMSISDSTTISAATLFLFMCLQPIIGG-LSDKIG 311
Cdd:cd17435 183 LVMKDNMRARLLIGLTLVFFVQITGQPNILFYAST------VLKSVGFQSNEAASLASTGVGVVKVVSTIPAIfLVDKVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 312 RRpiliAFGVLGTLFTVPILTTLhtiqswwGAFFLIMAALIIVSGYT----SINAVVKAELFPTEIRalgvGLPYALTVS 387
Cdd:cd17435 257 SK----TFLCIGSSVMAVSLVTM-------GLWLSLASLLVYVAAFSiglgPMPWLVLSEIFPGGIR----GRAMALTSS 321
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 518653971 388 IFGGTAEYIALWFKSIGMETGYYW--YVTACIAVSLMVYVTM 427
Cdd:cd17435 322 MNWGINLLISLTFLTVTELIGLPWvcFIYTAMSLASLVFVIM 363
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
60-176 |
5.95e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 5.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 60 GDTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSpgyeiigiGAPILLVFARLLQG 139
Cdd:cd17330 27 NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS--------RNLWLLFLARFLDG 98
|
90 100 110
....*....|....*....|....*....|....*..
gi 518653971 140 LSvGGEYGTSATYLSEMATKERRGfySSFQYVTLISG 176
Cdd:cd17330 99 LT-GGNVSVAQAYIADITDEEERA--KAFGIISAAFG 132
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
74-425 |
6.27e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 6.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 74 AVGFLMRPIGGWLmglyADKVGRKKALMASVYLMC-FGSLLIALSPGYEIIGIgapiLLVFARLLQGLSvggeygTSA-- 150
Cdd:cd17370 45 ALGSLLRLFSGYL----SDRTGKRKPLVILGYGLSaLAKPLLALAGSWQLVLL----LRILERLGKGIR------TPPrd 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 151 TYLSEMATKERR----GFYSSFQYVTLISGQLIALAVLIllqqvltteqLYAWGWRIPFAIG---ALCAVVALYLRRgme 223
Cdd:cd17370 111 ALLADATPPSGRgkafGLHRALDTLGAVLGPLLAALLLY----------LLGGNYRTIFLLAaipALLALLILLFVV--- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 224 etESFTKKEKAKESAMRTLMRH-PKELMTVVGLTMGGTLAFYTYTTYMqkYLVNTVGMSISDSTTISAATLFLFMCLQPI 302
Cdd:cd17370 178 --KEYPRPPKLRKKSKKTSLKKlPKAFWLYLLAVALFALGNFSFAFLI--LRAQELGLSAALIPLLYALFNLVYALAAYP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 303 IGGLSDKIGRRPiLIAFGVLGTLFTVPILTTLHtiqSWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPY 382
Cdd:cd17370 254 AGRLSDRIGRKK-LLILGYLSLALAYLGFALGS---SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFN 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 518653971 383 ALT-VSIFGGTAEYIALWfKSIGMETGyYWYVTACIAVSLMVYV 425
Cdd:cd17370 330 TVVgIGWLLASLIAGYLW-DLISPSAA-FLFSAVLALIALLLLL 371
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
260-382 |
7.61e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.37 E-value: 7.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 260 TLAFYTYTT-YMQKYLVNTV--------GMSISDSTTISAATLFLFMCLQPIIGGLSDKIGrRPILIAFGVLG-TLFTVp 329
Cdd:cd17328 2 AVLFLINLLnYMDRFTIAGVlpdiqsdfLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILIwSAATL- 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 518653971 330 iltTLHTIQSWWgaFFLIMAALIIV--SGYTSINAVVKAELFPTEIRALGVGLPY 382
Cdd:cd17328 80 ---LSSFAPNFW--QLLLFRALVGIgeASYSPIAPTIIADLFPKEKRTRALGVFY 129
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
70-161 |
9.26e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 37.90 E-value: 9.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518653971 70 AAIFAVGFLMRPIGGWLMGLYADKVGRKKALMASVYLMCFGSLLIALSPGYeiigigapILLVFARLLQGLSVGGEYGTS 149
Cdd:cd17372 37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNY--------MWLIILRCLVGLGLGGGPQLA 108
|
90
....*....|..
gi 518653971 150 ATYLSEMATKER 161
Cdd:cd17372 109 SWYLEFLPAKSR 120
|
|
| |
