|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
21-527 |
5.26e-136 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 400.36 E-value: 5.26e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 21 RKVIFASSLGTVFEWYDFFLYGALAA-VISKQFFAGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVT 99
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAAlVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 100 IILMGVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLV 179
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 180 VLACRYFTGD-QFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKACKAPIRESFgkWENLKVVLIALFsIN 258
Cdd:cd17369 161 FLLLSALLSDeAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVL--RRHWRALLLAIG-LR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 259 GGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIFKGLah 338
Cdd:cd17369 238 LAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLL-- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 339 ytnpamdQASQQAPITVLadpatctfqfdpvgkarfdspcdkvktflvkqglpyssaaapagspvqvsvgdvridgfdea 418
Cdd:cd17369 316 -------DTGSTWLIVLA-------------------------------------------------------------- 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 419 alrgAVALAGypssadvaqvnklmvvvlivvliFIAAMCYGPLAALMVELFPTRIRYTSMSLPYHIGNGWFGGFLPTVSF 498
Cdd:cd17369 327 ----AVVVLG-----------------------VLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIAT 379
|
490 500
....*....|....*....|....*....
gi 518659673 499 ALVVYTGDIFYGLWYPVVVTGVSLIVGLF 527
Cdd:cd17369 380 ALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
30-522 |
2.23e-92 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 288.02 E-value: 2.23e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 30 GTVFEWYDFFLYGALAAVISK-QFFAGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATF 108
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHtFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 109 CVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLACRYFTG 188
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 189 D-QFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKACKAPIRESFGKweNLKVVLIALFsINGGQAVTFYA 267
Cdd:TIGR00883 161 DdALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTK--HRKPFLLGLG-LVIATTTTFYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 268 AQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIFkglahytnpamdqa 347
Cdd:TIGR00883 238 ITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLL-------------- 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 348 sqqapitvladpatctfqfdpvgkarfdspcdkvktflvkqglpyssaaapagspvqvsvgdvridgfdeaalrgaVALA 427
Cdd:TIGR00883 304 ----------------------------------------------------------------------------MALL 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 428 GYPSSadvaqvnkLMVVVLIVVLIFIAAMCYGPLAALMVELFPTRIRYTSMSLPYHIGNGWFGGFLPTVSFALVVYTGDI 507
Cdd:TIGR00883 308 DSGSF--------TLFFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDW 379
|
490
....*....|....*
gi 518659673 508 FYGLWYPVVVTGVSL 522
Cdd:TIGR00883 380 YAIGYYLAALALIGL 394
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
24-344 |
5.09e-77 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 248.36 E-value: 5.09e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 24 IFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILM 103
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 104 GVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLAC 183
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 184 RYF-TGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKACKAPIRESFGKWENlkvvLIALFSINGGQA 262
Cdd:cd17367 161 QHTlGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRRHPRE----LLLVVGLTAGGT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 263 VTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIFKGLAHYTNP 342
Cdd:cd17367 237 LAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSP 316
|
..
gi 518659673 343 AM 344
Cdd:cd17367 317 YT 318
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
24-523 |
3.10e-69 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 228.03 E-value: 3.10e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 24 IFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILM 103
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 104 GVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSW---IQSTATLGLLLSLLVV 180
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWqsaSQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 181 LACryFTGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKAckapiRESFGKWENLKVVLIALFSINGG 260
Cdd:cd17368 161 SLT--LTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTR-----RELFALLANNRRIILLGMLLVAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 261 QAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIFKGLAHYT 340
Cdd:cd17368 234 STVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 341 NPAMdqasqqapitvladpatctfqfdpvgkarfdspcdkvktFLVKQGLpyssaaapagspvqvsvgdvridgfdeaal 420
Cdd:cd17368 314 SFGR---------------------------------------LLLVLLV------------------------------ 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 421 rgavalagypssadvaqvnklmvvvlivvLIFIAAMCYGPLAALMVELFPTRIRYTSMSLPYHIGNGWFGGFLPTVSFAL 500
Cdd:cd17368 325 -----------------------------LSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWL 375
|
490 500
....*....|....*....|...
gi 518659673 501 VVYTGDIFYGLWYPVVVTGVSLI 523
Cdd:cd17368 376 IELTGSPLAPAWYLMGAALLGLL 398
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
24-532 |
3.28e-66 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 219.15 E-value: 3.28e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 24 IFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILM 103
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 104 GVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLAC 183
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 184 RYFTGD-QFEVWGWRIPFLFSIVLLGISTWIRMSLHESpaflkmkeegkackapiresfgkwenlkVVLIALFSinggqa 262
Cdd:cd17366 161 TLLLTEaQMLDWGWRIPFLIAAPLGLVGLYLRRPLLIC----------------------------IGLVLVFN------ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 263 VTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLllatalyfpifkglahytnp 342
Cdd:cd17366 207 VTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGL-------------------- 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 343 amdqasqqAPITVLADPAtctfqfdpvgkarfdspcdkvktFLVKQGlpyssaaapaGSPVQVSVGdvridgfdeaalrg 422
Cdd:cd17366 267 --------AGLLVLAVPA-----------------------FLLMNS----------GSIAAIFIG-------------- 291
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 423 aVALAGYPSSadvaqvnklmvvvlivvlifiaamCY-GPLAALMVELFPTRIRYTSMSLPYHIGNGWFGGFLPTVSFALV 501
Cdd:cd17366 292 -LLVLGLLLS------------------------CYtATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLV 346
|
490 500 510
....*....|....*....|....*....|.
gi 518659673 502 VYTGDIFYGLWYPVVVTGVSLIVGLFcLKET 532
Cdd:cd17366 347 SATGNPLMPAYYLMVAAVVGLVAVLF-LTET 376
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-338 |
3.79e-61 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 207.66 E-value: 3.79e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 1 MSEHAQPLGSAASASTANESRKVIFASSLGTVFEWYDFFLYGALAA-VISKQFFAGVNDTTAFIFALMAFAAGFVVRPFG 79
Cdd:PRK09952 1 MDSTLISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAAlVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 80 ALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRG 159
Cdd:PRK09952 81 GVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 160 LHTSWIQSTATLGLLLSLLVVLACRYFTGD-QFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEE--GKACKAP 236
Cdd:PRK09952 161 FYSSGVQVGYGVGLLLSTGLVSLISMMTTDeQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEqaAAKKRIP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 237 IRESFGKWENLKVVLIALfsiNGGQAVTFYAAQFYVLFFLTQFLRMDpalANMLLIISVVIGA------PFfilFGWLSD 310
Cdd:PRK09952 241 VIEALLRHPGAFLKIIAL---RLCELLTMYIVTAFALNYSTQNLGLP---RELFLNIGLLVGGlscltiPC---FAWLAD 311
|
330 340
....*....|....*....|....*...
gi 518659673 311 KVGRKPVLMLGLLLATALYFPIFKGLAH 338
Cdd:PRK09952 312 RFGRRRVYITGALIGTLSAFPFFMALEA 339
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
21-333 |
1.59e-59 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 204.95 E-value: 1.59e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 21 RKVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTI 100
Cdd:PRK10642 15 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 101 ILMGVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVV 180
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 181 LACRYFTGDQ-FEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFL----KMKEEGKAC-----KAPIRESFGK-WENLKV 249
Cdd:PRK10642 175 VLISTIVGEAnFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQqhvdKLEQGDREGlqdgpKVSFKEIATKhWRSLLT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 250 VLIALFSINggqaVTFYAAQFYVLFFLTQFLRMDPAlANMLLIISVVIGAPFF-ILFGWLSDKVGRKPVLMLGLLLATAL 328
Cdd:PRK10642 255 CIGLVIATN----VTYYMLLTYMPSYLSHNLHYSED-HGVLIIIAIMIGMLFVqPVMGLLSDRFGRRPFVILGSVALFVL 329
|
....*
gi 518659673 329 YFPIF 333
Cdd:PRK10642 330 AIPAF 334
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-526 |
1.32e-52 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 182.42 E-value: 1.32e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 24 IFASSLGTVFEWYDFFLYGALAAVISKQFfagvNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILM 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 104 GVATFCVGLLPTyasigiaaPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLAC 183
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 184 RYFTGDqfeVWGWRIPFLFSIVLLGISTWIRMSlhespaflkmkeegkackapiresfgkwenlkvvLIALFSINGGQAV 263
Cdd:cd17316 149 IPLLSG---DWGWRILFLIGALPALLALLLRRR----------------------------------TLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 264 TFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIFKGLAHytnpa 343
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG----- 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 344 mdqasqqapitvladpatctfqfdpvgkarfdspcdkvktflvkqglpyssaaapagspvqvsvgdvridgfdeaalrga 423
Cdd:cd17316 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 424 valagypssadvaqvNKLMVVVLIVVLIFIAAMCYGPLAALMVELFPTRIRYTSMSLPYHIGNGWFGGFLPTVsFALVVY 503
Cdd:cd17316 267 ---------------SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLI-ALLLAS 330
|
490 500
....*....|....*....|...
gi 518659673 504 TGDIFYGLWYPVVVTGVSLIVGL 526
Cdd:cd17316 331 TGGTGVPALILALLAIVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
10-338 |
3.41e-50 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 178.21 E-value: 3.41e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 10 SAASASTANESR-KVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGD 88
Cdd:PRK15075 2 STMTPAASRESKaRAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYID 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 89 MIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQST 168
Cdd:PRK15075 82 RVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSAS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 169 ATLGLLLSLLVVLACRY-FTGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEegkacKAPIRESFGKW-EN 246
Cdd:PRK15075 162 QQVAVVFAALLGYLLNQwLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKH-----RPSMREIFRSLaAN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 247 LKVVLIALFSInGGQAVTFYAAQFYVLFFLTQFLRMDPALAnmlLIISVVIGAPFFI---LFGWLSDKVGRKPVLMLGLL 323
Cdd:PRK15075 237 WRIVLAGMLMV-AMTTVSFYLITVYTPTFGKTVLHLSAADS---LLVTLCVGVSNFIwlpIGGALSDRIGRRPVLIAFTV 312
|
330
....*....|....*
gi 518659673 324 LATALYFPIFKGLAH 338
Cdd:PRK15075 313 LAILTAYPALSWLVA 327
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-342 |
3.43e-48 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 172.69 E-value: 3.43e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 1 MSEHAQPLGSAASASTANESRKVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGFVVRPFGA 80
Cdd:PRK10406 1 MAESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 81 LVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGL 160
Cdd:PRK10406 81 WLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 161 HTSWIQSTATLGLLLSLLVVLACRY-FTGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPaflkmKEEGKACKAPirE 239
Cdd:PRK10406 161 YASFQYVTLIGGQLLALLVVVVLQQtLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETS-----QQETRALKEA--G 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 240 SF-GKWENLKVVLIALFSINGGqAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVL 318
Cdd:PRK10406 234 SLkGLWRNRRAFIMVLGFTAAG-SLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSM 312
|
330 340
....*....|....*....|....
gi 518659673 319 MLGLLLATALYFPIFKGLAHYTNP 342
Cdd:PRK10406 313 LCFGSLAALFTVPILSALQNVSSP 336
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-324 |
6.20e-30 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 119.15 E-value: 6.20e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 10 SAASASTANESRKVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDttafifALMAFAAGFVVRPFGALVFGRLGDM 89
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQ------LGWIVSAYLLGRAIGLLLFGRLGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 90 IGRKYTFLVTIILMGVATFCVGLLPTyasigiaaPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTA 169
Cdd:COG0477 76 YGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 170 TLGLLLSLLVVLACryftgdqFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKACKAPIRESFGKWENLKV 249
Cdd:COG0477 148 GLGLALGPLLGGLL-------VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLL 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518659673 250 VLIALFSINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLL 324
Cdd:COG0477 221 LLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-333 |
1.13e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.92 E-value: 1.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 14 ASTANESRKVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTafifalMAFAAGFVVRPFGALVFGRLGDMIGRK 93
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAG------LVVTAYLLGAALGAPLAGRLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 94 YTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGL 173
Cdd:COG2814 76 RVLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 174 LLSLLVVLACryftgdqFEVWGWRIPFLFSIVLLGISTWIrmslhespAFLKMKEEGKACKAPIRESFGKWENLKVVLIA 253
Cdd:COG2814 148 ALGPLLGGLL-------ADLFGWRWVFLVNAVLALLALLL--------LLRLLPESRPAARARLRGSLRELLRRPRLLLL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 254 LFsINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIF 333
Cdd:COG2814 213 LL-LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA 291
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-333 |
5.60e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.89 E-value: 5.60e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 21 RKVIFASSLGTVFEWYDFFLYGALAAVISKQFfaGVNDTTAFifalMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTI 100
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF--GLSAAQLG----LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 101 ILMGVATFCVGLLPTYasigiaapIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVV 180
Cdd:COG2223 78 LLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 181 LACryftgdqFEVWGWRIPFL-FSIVLLGISTWIRMSLHESPAFlkMKEEGKACKAPIRESFGKWENLKVVLIALFSING 259
Cdd:COG2223 150 PLL-------IAAFGWRNAFLiLGILLLVVAVLAWLFLRDPPAG--AAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518659673 260 GQAVTFYAAQFYVLFFltqflRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIF 333
Cdd:COG2223 221 FIGFSSWLPPYLVDQF-----GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
22-332 |
7.86e-25 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 107.36 E-value: 7.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 22 KVIFASSLGTVFeWYDFFLYGALAAVISKQFFAGVN-----DTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTF 96
Cdd:pfam00083 1 VALVAALGGFLF-GYDTGVIGAFLTLIDFFKNFGLSksvssLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 97 LVTIILMGVATFCvgllpTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLS 176
Cdd:pfam00083 80 LIANVLFVIGAVL-----QGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 177 LLVVlacrYFTGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFL------------------------KMKEEGKA 232
Cdd:pfam00083 155 YIFG----LGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLvekgrleearevlaklrgvpdvdrELDEIKDS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 233 CKAPIRESFGKWENLK------VVLIALFSINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILfg 306
Cdd:pfam00083 231 LEAGQEAEKASWKELFstktrrQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAI-- 308
|
330 340
....*....|....*....|....*.
gi 518659673 307 WLSDKVGRKPVLMLGLLLATALYFPI 332
Cdd:pfam00083 309 FLVDRFGRRPLLLLGAAGMAICFVIL 334
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-330 |
4.01e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.94 E-value: 4.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 21 RKVIFASSLGTVFEWYDFFLYGALAAVISKQFfaGVNDTTAFifalMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTI 100
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLG----LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 101 ILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVV 180
Cdd:COG2271 83 LLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 181 LACryftgdqFEVWGWRIPFLFSIVLLGISTWIRmslhespaflkmkeegkackapiresfgkwenlkvvLIALFSINGG 260
Cdd:COG2271 155 GWL-------LAAFGWRAAFLILGLPGLLLALLR------------------------------------FWLLALAYFL 191
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518659673 261 QAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGR--KPVLMLGLLLATALYF 330
Cdd:COG2271 192 VYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALL 263
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
67-332 |
1.82e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.02 E-value: 1.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 67 MAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYGGAA 146
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 147 TYVAEHAPPGKRGLHTSWIQSTATLGLLLSLlvvlacrYFTGDQFEVWGWRIPFLFSIVLLGISTWIRMS-LHESPAFLK 225
Cdd:cd17325 107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGP-------LLGGLLADALGYRAPFLVCAALALLALVLALLlLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 226 MKEEGKACKAPIRESFGKWENLKVVLIALFSinggQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILF 305
Cdd:cd17325 180 KRAVSAARLRSGLRLLLRDRRLLALFLAIFV----LAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260
....*....|....*....|....*..
gi 518659673 306 GWLSDKVGRKPVLMLGLLLATALYFPI 332
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAVALLLL 282
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-332 |
2.15e-20 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 93.14 E-value: 2.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 25 FASSLGTVFEWYDFFLYGALAAVIsKQFFAGVNDTTAFIFALMAFAAGFvvrpfGALVFGRLGDMIGRKYTFLVTIILMG 104
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPAL-IAEFGLDEAEAGLLGTVTLAGGAI-----GGILGGILADRFGRVRVLVITILLFA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 105 VATFCVGLLPTYasigiaapIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLAcr 184
Cdd:cd17371 76 VFTLLCGFAQNY--------WQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAL-- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 185 yFTGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKACKAP--IRESFGKwENLKVVLIAlFSINGGQA 262
Cdd:cd17371 146 -LFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRpsLRELFSP-PLLRTTLLA-SLLATGAL 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518659673 263 VTFYAAQFYVLFFLTQFLRMD---PALANMLLIISVVIGapfFILFGWLSDKVGRKPVLMLGLLLA---TALYFPI 332
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSfegSAGYLVVTILGGFLG---YLAGGFLADRIGRRNNFALFALGSaisILLYFFL 295
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
1-241 |
7.85e-16 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 80.13 E-value: 7.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 1 MSEHAQPLGSAASASTANesRKVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIfalmafAAGFVVRPFGA 80
Cdd:PRK03893 1 MSTTTQNIPWYRHLNRAQ--WKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLI------SAAFISRWFGG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 81 LVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAapiilivlRMLQGLALGGEYGGAATYVAEHAPPGKRGL 160
Cdd:PRK03893 73 LLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIA--------RLVIGMGMAGEYGSSATYVIESWPKHLRNK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 161 HTSWIQSTATLGLLLSLLVVLACryftgdqFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFlkmkEEGKACKAPIRES 240
Cdd:PRK03893 145 ASGFLISGFSIGAVVAAQVYSLV-------VPVWGWRALFFIGILPIIFALWLRKNLPEAEDW----KEKHAGKAPVRTM 213
|
.
gi 518659673 241 F 241
Cdd:PRK03893 214 V 214
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
21-334 |
8.53e-16 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 79.59 E-value: 8.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 21 RKVIFASSLGTVFEWYDFFLYGALAAVISKQFfaGVNDTTAFIFALMAFAAgfvvRPFGALVFGRLGDMIGRKYTFLVTI 100
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADL--GLTDMEGAFLATAAFIG----RPFGGALFGLLADKFGRKPLMMWSI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 101 ILMGVATFCVGLlptyasigIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLlvv 180
Cdd:PRK12307 91 VAYSVGTGLSGL--------ASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAA--- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 181 lacrYFTGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKACKAPIRESFGKWENLKV----------- 249
Cdd:PRK12307 160 ----YFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLfnraqfpltlc 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 250 VLIALFSInggqavtfYAAQFYVLFFLTQFLR---MDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLAT 326
Cdd:PRK12307 236 VFIVLFSI--------FGANWPIFGLLPTYLAgegFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSF 307
|
....*...
gi 518659673 327 ALYFPIFK 334
Cdd:PRK12307 308 LFIFPLFR 315
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-333 |
3.01e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.07 E-value: 3.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 28 SLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGFvvrpfGALVFGRLGDMIGRKYTFLVTIILMGVAT 107
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYAL-----AQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 108 FCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLACryft 187
Cdd:pfam07690 77 LLLLFASSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL---- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 188 gdqFEVWGWRIPFLFSIVLLGISTWIRMsLHESPAFLKMKEEGKACKAPIRESFGKWENLKVVLIALFSINGGQAVTFYa 267
Cdd:pfam07690 145 ---ASLFGWRAAFLILAILSLLAAVLLL-LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGL- 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518659673 268 aqFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIF 333
Cdd:pfam07690 220 --LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL 283
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
24-333 |
1.21e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.66 E-value: 1.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 24 IFASSLGTVFEWYDFFLYGALAAVISKQFfaGVNDTTAfIFALMAFAAGFVVrpfGALVFGRLGDMIGRKYTFLVTIILM 103
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDF--GVSVAQA-GLLVSAYALGYAL---GALLLGPLSDRIERRRLLLVLLLLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 104 GVATFCVGLLPTYASigiaapiiLIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATlglllslLVVLAC 183
Cdd:cd17324 75 ILGNLLAALAPSFAL--------LLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLT-------LGLVLG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 184 RYFTGDQFEVWGWRIPFL-FSIVLLGISTWIRMSLHESPAFLKMKeegkacKAPIRESFGKWENLKVVLIAL--FSINGG 260
Cdd:cd17324 140 RPLGGLLGQLLGWRAAFLaIAVLALLAALLLWRLLPSLPPKKPGS------LGLLSSLLLLLRNPRLRLAYLitFLLFGG 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518659673 261 qavtFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYFPIF 333
Cdd:cd17324 214 ----FFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL 282
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
36-330 |
2.92e-11 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 65.38 E-value: 2.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 36 YDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAgFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPT 115
Cdd:cd17364 13 YDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAA-LVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 116 YASIGIAApiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQST----ATLGLLLSLLVVLACRYFTGDQF 191
Cdd:cd17364 92 STPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMqgfgILAGAIVTLILSAIFEHPLPAGT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 192 EV---WGWRIPFLFSIVLLGISTWIRMSLhespaflkmkeegkackapiresFGKWENLKVVLIALFSINGGQAVTFYAA 268
Cdd:cd17364 170 YHhadLVWRIVLGLGAIPALSVLYFRKHL-----------------------LGTAGTWFLLDIAFYGQNLFQSTIISAI 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518659673 269 QFYVLFFLTQFLrMDPALANmlLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYF 330
Cdd:cd17364 227 GFSKTMNAYQEL-FNIAVGQ--LIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLL 285
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
22-336 |
5.70e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 64.30 E-value: 5.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 22 KVIFASSLGTVFEWYDFFLYGALAAVISKQFfagvNDTTAFIFALMAFAAGFVVrpFGALVFGRLGDMIGRKYTFLVTII 101
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEW----GLDPVQLGFLFSAGLIGMA--FGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 102 LMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSLlvvl 181
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGG---- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 182 acrYFTGDQFEVWGWRIPFLFSIVLLGISTW-IRMSLHESPAFLKMKEEGKACKAPIR--------------ESFGKWEN 246
Cdd:TIGR00895 159 ---FLAGWLIPVFGWRSLFYVGGIAPLLLLLlLMRFLPESIDFLVSKRPETVRRIVNAiapqmqaeaqsalpEQKSTQGT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 247 LKVVLIALFS-INGGQAVTFYAAQFYVLF----------FLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRK 315
Cdd:TIGR00895 236 KRSVFKALFQgKTARITVLLWLLYFMLLVgvyfltnwlpKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR 315
|
330 340
....*....|....*....|.
gi 518659673 316 pVLMLGLLLATALYFPIFKGL 336
Cdd:TIGR00895 316 -VTALLLLLGAVFAVLVGSTL 335
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
78-330 |
2.04e-10 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 62.65 E-value: 2.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 78 FGALVFGRLGDMIGRKYTflvtiILMGVATFCVGLLPTYASIGIAAPiiLIVLRMLQGLALGGEYGGAATYVAEHAPPGK 157
Cdd:cd17356 60 FGALISSFLSDRIGRKKS-----IQIGCVIYIIGAIIQVAAIGKWYQ--LIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 158 RGLHTSWIQSTATLGLLLSLLVVLACRYFTGdqfEVWgWRIP----FLFSIVLLGISTWIrmslHESPAFLKmkeegKAC 233
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAYCINYGTHKLDG---SAQ-WRIPlglqIVWGLLLLIGMFFL----PESPRWLY-----RTI 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 234 KAPIRESFGKWenlkvvlialfsiNGGQAVTFYAAQFyvlFFLTQFLRMDPALANM-LLIISVV--IGAPFFIlfgwlsD 310
Cdd:cd17356 200 LGIMLQLFQQL-------------TGINYFFYYGTTI---FQSTGLTGSSPLLTSIiLYIVNFVstIPGLFFV------D 257
|
250 260
....*....|....*....|
gi 518659673 311 KVGRKPVLMLGLLLATALYF 330
Cdd:cd17356 258 KFGRRTCLLIGAAGMSICLF 277
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
67-333 |
3.79e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 61.67 E-value: 3.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 67 MAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYasigiaapIILIVLRMLQGLALGGEYGGAA 146
Cdd:cd06174 35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 147 TYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLACryftgDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKM 226
Cdd:cd06174 107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL-----ASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 227 KEEGKACKAPIRESFGKWENLKVVLIALFSInGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFG 306
Cdd:cd06174 182 AKNEEASSKSVLKLLKRVLKNPGLWLLLLAI-FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260
....*....|....*....|....*...
gi 518659673 307 WLSDKV-GRKPVLMLGLLLATALYFPIF 333
Cdd:cd06174 261 LLSDRLiGRKPLLLIGLLLMALGLALLL 288
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
48-327 |
3.30e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 58.72 E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 48 ISKQFFAGVNDTTAFIFALMAFAAGFVvrpfgaLVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTyasigiaaPIIL 127
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALL------LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 128 IVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTAtlglllsLLVVLACRYFTGDQFEVWGWRIPFLFSIVLL 207
Cdd:cd17321 88 IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVV-------GIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 208 GISTWIrmslheSPAFLkmkeegkackapiresfgkwenlkVVLIALFSINGGQAVTFyaaqFYVLFFLTQFLRMDPALA 287
Cdd:cd17321 161 LVALLL------ARTFS------------------------GAVLAAFLLGAALGGLL----FLLPLYLQGVLGYSPLQA 206
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 518659673 288 NMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATA 327
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-333 |
3.31e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.15 E-value: 3.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 20 SRKVIFASSLGTVFEWYDFFLYGALAAVISKQFFaGVNDTTAFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTF-LV 98
Cdd:COG2211 8 SLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVL-GLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWiLI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 99 TIILMGVATFCVGLLPTYASIG--IAAPIILIVLRMLQGL------ALGGEYGGaatyvaehaPPGKRGLHTSWIQSTAT 170
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLAYTLvnipysALGAELTP---------DYEERTRLSSWRFAFAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 171 LGLLLSLLVVLACRYFTGDQfEVWGWRIPFLFSIVLLGISTWIrmslhespAFLKMKEEgkacKAPIRESFGKWENLKVV 250
Cdd:COG2211 158 LGGLLASVLPPPLVAAFGGD-AALGYRLTALIFAVLGLLAFLL--------TFFGTKER----PVPEEEKVSLKESLKAL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 251 -----LIALFSINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLA 325
Cdd:COG2211 225 lknrpFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
....*...
gi 518659673 326 TALYFPIF 333
Cdd:COG2211 305 ALGLLLLF 312
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
58-330 |
5.39e-09 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 58.36 E-value: 5.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 58 DTTAFIFALMAFAAgfvvrPFGALVFGRLGDMIGRKYTFLVTIILmgvatFCVGLLPTYASIGIaapIILIVLRMLQGLA 137
Cdd:cd17358 41 AQFSWFGSLLTLGA-----LIGALLSGKLADRIGRKRTLLISAIP-----CILGWLLIAFAKDV---WMLYLGRFLAGFG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 138 LGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSllvvlacrYFTGDQFEvwgWRIPFLFSIVLLGISTWIRMSL 217
Cdd:cd17358 108 GGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLG--------YVLGSFLP---WRTLALIGAIPPVVFLILLFFI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 218 HESPAFLKMKEEGKAC-----------------KAPIRESF---------GKWENLK--------VVLIALFSIN---GG 260
Cdd:cd17358 177 PESPRWLAKKGREEEAekslqflrgkdadiskeAAEIQEELaelekeakeSSFSDLFqrkylkplVIGLGLMLFQqlsGI 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518659673 261 QAVTFYAAQfyvlFFLTQFLRMDPALANMLLIISVVIGApffILFGWLSDKVGRKPVLM---LGL---LLATALYF 330
Cdd:cd17358 257 NAVIFYASS----IFDEAGSGLDPNTATIIIGVVQVVGT---LVATLLVDRLGRRPLLLvsaIGMgigLLALGLYF 325
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
39-330 |
9.47e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 57.58 E-value: 9.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 39 FLYGALAAVISkqffaGVNDTTAFIFALMAFAAGFVVRP------FGALVFGRLGDMIGRKYTFLVTIILmgvatFCVGL 112
Cdd:cd17359 11 LLFGYDTGVIN-----GALPFLQTDFNLTPFLEGLVVSSallgaaIGALFAGRLADRFGRRKTLLISAVL-----FFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 113 LPTYASIGIAapiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQ-STATLGLLLSLLVVLACRYFTGDQF 191
Cdd:cd17359 81 LGSAFSPNFT---IFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQlMIVFGQLLAYIVNYLIANAGGADWL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 192 EVWGWRIPFLFSIV---LLGISTWIrmsLHESPAFLKMKeegkackapiresfGKWENLKVVLIALFS-INGGQAVTFYA 267
Cdd:cd17359 158 GAEGWRWMLGLEAIpaiLFLLGMLF---IPESPRWLVSK--------------GKPILIIGIGLAIFQqFVGINVIFYYG 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518659673 268 aqfyvlfflTQFLRMDPALANMLLIISVVIGAP---FFILFGWLSDKVGRKPVLMLG--------LLLATALYF 330
Cdd:cd17359 221 ---------PEIFQNAGFSENAALLQTIGIGVVnviFTIIAILLVDKVGRKPLLLIGsigmaislLLIGTAFYF 285
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
70-330 |
3.86e-08 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 55.89 E-value: 3.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 70 AAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAApiILIVLRMLQGLALGGEYGGAATYV 149
Cdd:TIGR00887 63 GSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIIT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 150 AEHAPPGKRGLHTSWI---QSTATLGLLLSLLVVLAC----RYFTGDQFEVWG---------WRIPFLFSIVLLGISTWI 213
Cdd:TIGR00887 141 SEFATKKWRGAMMAAVfamQGFGILAGAIVALIVLAGfkhsLEAAADEASCTGscvpavdymWRILIGFGAVPALLALYF 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 214 RMSLHESP------------------AFLKMKEEG---------KACKAPIRES------FGKWENLKVVL--------- 251
Cdd:TIGR00887 221 RLTIPETPrytadvakdveqaasdmsAVLQVKIEAepdevekasTAVEVPKASWsdffthFFKWRHGKHLLgtagswfll 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 252 -IALFSINGGQAVTFYAAQFYVLFFLTQFLR--MDPALANMLLIISVVIGAPFFILFgwLSDKVGRKPVLMLGLLLATAL 328
Cdd:TIGR00887 301 dIAFYGVNLNQKVILSAIGYSPPAATNNAYEelYKTAVGNLIIALAGTVPGYWVTVF--LVDIIGRKPIQLMGFFILTVL 378
|
..
gi 518659673 329 YF 330
Cdd:TIGR00887 379 FF 380
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-160 |
7.09e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.51 E-value: 7.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 31 TVFEWYDFFLYGALAAVISKQFFAGVNDTTAFifalmaFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCV 110
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQDWGLSPAQLGPV------GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 518659673 111 GLLPTYASIGIaapiilivLRMLQGLALGGEYGGAATYVAEHAPPGKRGL 160
Cdd:cd17365 82 AFAQSVLQLAL--------LRFLTGLGLGAAMPNAITLVSEYAPARRRSL 123
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
39-331 |
2.00e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 53.35 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 39 FLYGALAAVISKqffAGVNDTTAFIFALMAFAAGFVVRPF------GALVFGRLGDMIGRKYTFLVTIILMGVATFCVGL 112
Cdd:cd17315 7 LLFGYDLGVING---ALLYIAKDLGFGLSTSLQGLVVSSLllgaaiGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 113 LPTYAsigiaapiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSllvvlacrYFTGDQFE 192
Cdd:cd17315 84 APNVW--------VLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLA--------YLLGLALS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 193 V---WGWRIPFLFSIVLLGISTWIRMSLHESPAFLkmkeegkackapiresfgkwenLKVVLIALFSINGGQAVTFYAAQ 269
Cdd:cd17315 148 LsppGWWRLMFALAAVPALLQLLLMFFLPESRALL----------------------VGVGLQLLQQLTGINAVMYYAPT 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518659673 270 fyvlfFLTQFLRMDPAlanmlLIISVVIGAPFFI---LFGWLSDKVGRKPVLMLG--------LLLATALYFP 331
Cdd:cd17315 206 -----IFKSAGGGTAS-----ILASIIVGVVNLLatlVAIRLVDKVGRRPLLLIGfagmaaslLLLAIAFLLP 268
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
64-337 |
3.12e-07 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 52.74 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 64 FALMAFAAGFVVRP------FGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLA 137
Cdd:cd17362 34 YNLSSLQSGLVVSGsllgalLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 138 LGGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSllvvlacrYFTGDQF--EVWGWRIPFLFSI---VLLGISTW 212
Cdd:cd17362 106 IGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLG--------YVSGYAFadVVGGWRYMYGLAAppaLLLGIGMW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 213 irmSLHESPaflkmKEEGKACKAPIresfgkwenLKVVLIALFSINGGQAVTFYAAQFyvlffltqFLRMDPALANMLLI 292
Cdd:cd17362 178 ---FLPPSP-----RWQGNYRKPLI---------IGLGLVLFQQITGQPSVLYYAATI--------FKSAGFSAASDATL 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 518659673 293 ISVVIGApFFILFGW----LSDKVGRKPVLMLG-------LLLATALYFPIFKGLA 337
Cdd:cd17362 233 VSVGLGV-FKLLMTIvavlLVDKLGRRPLLLGGvsgmvvsLFLLAAYNLFVQMGPA 287
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
78-343 |
4.53e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 52.24 E-value: 4.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 78 FGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLALGGEYGGAATYVAEHAPPGK 157
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV--------LLVLLFLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 158 RGLHTSWIQSTATLGLLLSLLVVLACryftgdqFEVWGWRIPFLFSIVLLGISTWIRM-SLHESPAFLKMKEEGKACKAP 236
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPPL-------ALHYGWRAAFVVAGLVSILAAVLFWlFYREPPAASAATESASTLLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 237 IRESFGKWeNLKVVLIALFSINGGQavtfYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKV--GR 314
Cdd:cd17475 191 LKEVLRNR-DVWLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGR 265
|
250 260
....*....|....*....|....*....
gi 518659673 315 KPVLMLGLLLATALYFPIFKGLAHYTNPA 343
Cdd:cd17475 266 RRPVLVITAAIAAAALLVLSLLSPGTPLW 294
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
78-324 |
4.57e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 52.26 E-value: 4.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 78 FGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLlptyaSIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGK 157
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSEL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 158 RGLHTSWIQSTATlgLLLSLLVVLACRYFTGDQFevwGWRIPFLFSIVLLGISTWIRMSLHESPAFL--KMKEEGKACKA 235
Cdd:cd17357 139 RGALGSLTQIGVT--LGILLGQVFGLPSVLGTET---LWPYLLFFPGIPALLQLAALPFFPESPKFLliSKGDEEEAEKS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 236 ------------------------PIRESFGK-WE-----NLKVVLIALFSINGGQAVT-FYAAQFYVLFFLTQ--FLRM 282
Cdd:cd17357 214 lkflrgieddvdqeleeikkeseqMGDQKQVSlMQllrdpSLRLPLLLVLVVSASQQFSgINAIFFYSTFIFENagFSPQ 293
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 518659673 283 DPALANMLLIISVVIGApffILFGWLSDKVGRKPVLMLGLLL 324
Cdd:cd17357 294 LAEWANLGIGIVNVLST---IVGPFLIEKVGRRPLLLISLSV 332
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
82-333 |
5.74e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.79 E-value: 5.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 82 VFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAAPIILIvlrmlqGLALggeYGGAATYVAEHAPPGKRGLH 161
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI------GSAA---FHPEGARLASQAAGGRRGLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 162 TSWIQSTATLGLLLSLLVVLAcrYFTGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPAFLKMKEEGKACKAPIResf 241
Cdd:cd17478 121 MSIFSVGGNLGFALGPLIAAA--LVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWR--- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 242 gkwenlkvVLIALFSINGGQAVTFYAAQFYVLFFLTQFLrMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLG 321
Cdd:cd17478 196 --------ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIAS 266
|
250
....*....|..
gi 518659673 322 LLLATALYFPIF 333
Cdd:cd17478 267 LLLAAPFLLLFL 278
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
251-330 |
9.80e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.99 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 251 LIALFSINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYF 330
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
80-330 |
1.13e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.57 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 80 ALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYasigiaapIILIVLRMLQGLAlGGEYGGAATYVAEHAPPGKRG 159
Cdd:cd17504 48 TPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL--------PVLIAGRALQGIG-GAVFPLAFALVREEFPPERVP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 160 LHTSWIQSTATLGLLLSLLvvlacryFTGDQFEVWGWR----IPFLFSIVLLGISTWIRMSLHESPAFLkmkeegkacka 235
Cdd:cd17504 119 VAQGILSATFGIGAGIGLP-------LGGWIVQHLGWRwifwTAAPVAVLLAALVPLIDLRLLRRRNVL----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 236 piresfgkwenlkVVLIALFSINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRK 315
Cdd:cd17504 181 -------------LANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
250
....*....|....*
gi 518659673 316 PVLMLGLLLATALYF 330
Cdd:cd17504 248 RVLLIGLVISAVGLL 262
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
38-159 |
1.38e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.45 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 38 FFLY-GALAAVISkqfFAGV----------NDTTAFIFALMAFAAgfvvrpFGALVFGRLGDMIGRKYTFLVTIILMGVA 106
Cdd:COG2270 247 YFFYrDGVQTVIA---FAGIyaagvlgfstTELIVFGLLVQIVAA------LGALLFGRLDDRIGPKRVILVSLVIWIVV 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 518659673 107 TFCVGLLPTYASIGIAAPIIlivlrmlqGLALGGEYGGAATYVAEHAPPGKRG 159
Cdd:COG2270 318 CLAAYFLTTALAFWILGLLI--------GLVMGGIQALSRSLLARLIPPGREA 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
38-330 |
2.28e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 38 FFLYGALAAVIS------KQFFaGVNDTTAFiFALMAFAAGFVVrpfGALVFGRLGDMIGRKYTFLVTIILMGVATFCVG 111
Cdd:COG0738 17 FFLWGFATALWGplipalKDAF-GLSDAQAG-LLLFAFFLGYLL---ASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 112 LLPTYasigiaapIILIVLRMLQGLALGGEYGGAATYVAEHaPPGKRGLHTSWIQ---STATLGLLLSLLvvlacrYFTG 188
Cdd:COG0738 92 LAPSY--------PLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHaffSLGALLGPLLGG------LLIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 189 DQFEVwGWRIPFLFSIVLLGISTWIrMSLHESPAFLKMKEEGKACKAPIRESFgKWENLKVVLIALFSINGGQAvtfyAA 268
Cdd:COG0738 157 LGLSL-SWHLPYLILAVLLLLLALL-FLRSKLPEIEEEEEEAAGSAASLKSLL-KNPRLLLGGLAIFLYVGAEG----AI 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518659673 269 QFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYF 330
Cdd:COG0738 230 GDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-327 |
2.49e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 2.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 69 FAAGFVVRPFGalvfGRLGDMIGRKYTFLVTIILMGVATFCVGLlptyasigIAAPIILIVLRMLQGLALGGEYGGAATY 148
Cdd:cd17489 41 TLAALLARPFA----GRLLDRFGRKRLLLIGLLIFALATLLYLL--------ATSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 149 VAEHAPPGKRGLHTSWIQSTATLGLLLSLLVVLACryftgdqFEVWGWRIPFLFSIVLLGISTWIRMSLHESPaflkmkE 228
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL-------YQHLGFAVLFIVAAVLALLALLLVFLVKDPP------P 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 229 EGKACKAPIRESFGKWENLKVVLIALFSIngGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFilfGWL 308
Cdd:cd17489 176 VAAEEAEAGTRAFRRLVEKKVLPPALILF--LASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFS---GKL 250
|
250
....*....|....*....
gi 518659673 309 SDKVGRKPVLMLGLLLATA 327
Cdd:cd17489 251 SDRKGPKTVIIPGLLLLAL 269
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
33-224 |
4.04e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 46.51 E-value: 4.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 33 FEWYDFFLYG-ALAAVISKQFFAG-----------VNDTTAFIFALMAFAAGFVvrpfGALVFGRLGDMIGRKYTFLVTI 100
Cdd:TIGR01299 164 FQWALFFVLGlALMADGVEVFVVGfvlpsaekdlcIPDSGKGMLGLIVYLGMMV----GAFFWGGLADKLGRKQCLLICL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 101 ILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSW------IQSTATLGLL 174
Cdd:TIGR01299 240 SVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWlcmfwmIGGIYAAAMA 311
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 518659673 175 LSLLVVLACRYFTGDQFEVWGWRI-------PFLFSIVLLgistwirMSLHESPAFL 224
Cdd:TIGR01299 312 WAIIPHYGWSFQMGSAYQFHSWRVfvivcafPCVFAIGAL-------TFMPESPRFF 361
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-330 |
4.91e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 48 ISKQFfagVNDTTAFIFALMAFAAGFVVrpFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIgiaapiil 127
Cdd:cd17473 25 IAQHF---VPNSELLVPLLLTLPALFIA--LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL-------- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 128 IVLRMLQGLALGGEYGGAATYVAEHAPPGKRglhTSWI--QSTATLGLLLSLLVVlacryftGDQFEVWGWRIPF---LF 202
Cdd:cd17473 92 LASRALLGIGVAGIMTLATALIGDYFEGEER---AKMLglQSAAMSLGGVVFLLL-------GGALAEIGWRAPFlvyLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 203 SIVLLGISTWirmSLHESPAflkmKEEGKACKAPIRESFGKWENLKVVLIALFsingGQAVTFYAAQFYVLFFLTQFLRM 282
Cdd:cd17473 162 ALPVLILVLL---FLPEPAR----KSKSAASPGAATAAALPWKRVLPIYFLAF----LAMLLFYVIPIQLPFLLQERGGG 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 518659673 283 DPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATALYF 330
Cdd:cd17473 231 SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-167 |
5.33e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 5.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 20 SRKVIFASSLGTVFEWYDFFLYGALAAVISKQFFaGVNDTTAFIFALMAFAAGFVvrpfGALVFGRLGDMIGRKYTFLVT 99
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVL----GALLAGRLADRFGRRRLLLIG 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518659673 100 IILMGVATFCVGLLPTyasigiaaPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQS 167
Cdd:COG2814 280 LLLLALGLLLLALAGS--------LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNS 339
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
63-332 |
7.64e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.95 E-value: 7.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 63 IFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLaLGGEY 142
Cdd:cd17391 36 LWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGV-FSGYV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 143 GGAATYVAEHAPPGKRGlhtsWIQSTATLGLLLSLLVVLACRYFTGDQFevwGWRIPFLFSIVLLGISTWIRMslhespa 222
Cdd:cd17391 107 PNATALIASQTPKEKSG----WALGTLSTGVVAGTLIGPLLGGFLADLF---GIRNVFFITGGLLFLAFLLTL------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 223 fLKMKEEGKACKAPIRESFGK-WENL--KVVLIALFsinggqaVTFYAAQF---YVLFFLTQFLR-MDPALANMLLIISV 295
Cdd:cd17391 173 -FFVKEDFKPVEKKKMVSTKEvWNSVpnPSLLISLF-------VTTFIIQLanqSIEPILTLYIRqLMGDASNLAFISGL 244
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 518659673 296 VIGAPFF--ILF----GWLSDKVGRKPVLMLGLLLATALYFPI 332
Cdd:cd17391 245 VFSATGVssLLSaprlGKLGDRIGHHRILLGALLASALLYIPQ 287
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
67-330 |
1.01e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 67 MAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYGGAA 146
Cdd:cd17474 38 LLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGLGPLAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 147 TYVAEHAPPGKRGLHTSWIQSTATLGLLLSLLVvlacryftGDQFEVWGWRIPFLFSIVLLGISTWIRMSLHESPaflkm 226
Cdd:cd17474 110 TLIGDLFEGGERAKAMGLYEAALGLGIAVGPLL--------GGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 227 KEEGKACKAPIRESFGKWENLKVVLIALFSinggqAVTFYAAQFYVLFFLTQFLRMDPALAN-----MLLIISVVIGAPF 301
Cdd:cd17474 177 KEKAKSSSATKLRDLKKALRGRGLLTFLVS-----AFLYFFLYFAFLTYLPFLLELLYGISPiiiglLFAGWSVLLALGS 251
|
250 260
....*....|....*....|....*....
gi 518659673 302 FILFGWLSDKVGRKPVLMLGLLLATALYF 330
Cdd:cd17474 252 LFVGRLLKKRFGARRILVIGLLLYALSLL 280
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
68-159 |
1.01e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.95 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 68 AFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLALGGEYGGAAT 147
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIA 126
|
90
....*....|..
gi 518659673 148 YVAEHAPPGKRG 159
Cdd:PRK11551 127 LTSEAVGPRLRG 138
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
38-328 |
1.23e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.48 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 38 FFLYGALAAVISKQFfaGVNDTTA-FIFALMAFAAGFvvrpfGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTY 116
Cdd:COG2807 34 ITSVGPLLPEIRADL--GLSATQAgLLTTLPLLAFGL-----FAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 117 ASigiaapiiLIVLRMLQGLALGGEYGGAATYVAEHAPpGKRGLHTSWIQSTATLGLLLSLlvvlacrYFTGDQFEVWGW 196
Cdd:COG2807 107 AL--------LLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAA-------GLTVPLAAALGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 197 RIPFLFSIV--LLGISTWIRMSLHESPAflkmkeegkACKAPIRESFGK-WENLKVVLIALFSinGGQAVTFYAaqfyVL 273
Cdd:COG2807 171 RGALAVWALlaLLALLLWLPLLRRRPAA---------AAAAPAAASLRSlWRSPLAWLLTLFF--GLQSLLYYA----VV 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 518659673 274 FFLTQFLR---MDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATAL 328
Cdd:COG2807 236 AWLPPILRdagLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
21-170 |
1.40e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 21 RKVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAgfvvrPFGALVFGRLGDMIGRKYTFLVTI 100
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA-----LVGALIAGLLSDRIGRKKTLVIGL 250
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 101 ILMGVatfcvgLLPTYASIGIAAPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQSTAT 170
Cdd:cd17316 251 ILSGI------LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGR 314
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
59-333 |
1.59e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.15 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 59 TTAFIFALMAFAagfvvrpfgaLVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLAL 138
Cdd:cd17328 40 QTVFIISYMVLS----------PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVGIGE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 139 GGEYGGAATYVAEHAPPGKRGLHTSWIQSTATLGLLLSllvvlacrYFTGDQF--EVWGWRIPFLFSIVL-LGISTWIRM 215
Cdd:cd17328 102 ASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG--------YVVGGLVaqATGGWRWAFRVTGVLgVLLAILLLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 216 SLHESPafLKMKEEGKACKAPIRESFGKWENLKVVLIALFSINGGQAVTFYA---AQFYVLFFLTQFLRMDPALANM--- 289
Cdd:cd17328 174 FVREPP--RGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTgalAFWAPTFFLRAFGVGDLSSADVgli 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 518659673 290 LLIISVVIGAPFFILFGWLSDKVGRKP------VLMLGLLLATALYFPIF 333
Cdd:cd17328 252 FGAITCIAGVLGVLLGGILADRLRRKTpradplVCAVGLLAAAPFLFLAL 301
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
64-158 |
2.17e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.34 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 64 FALMAFAAGFVVrpfGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYG 143
Cdd:cd17317 29 LVQTIFFLGVLI---GSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFT 97
|
90
....*....|....*
gi 518659673 144 GAATYVAEHAPPGKR 158
Cdd:cd17317 98 VGFVLGMEIVGPKYR 112
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
78-163 |
2.78e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 43.16 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 78 FGALVFGRLGDMIGRKYT-------FLVTIILMGVAtfcvgllPTYAsigiaapiILIVLRMLQGLALGGEYGGAATYVA 150
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTialaaliFFVGALLMGVA-------PNYP--------VLMVGRFVAGIGVGFALMIAPVYTA 111
|
90
....*....|...
gi 518659673 151 EHAPPGKRGLHTS 163
Cdd:cd17437 112 EVAPASSRGFLTS 124
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
66-159 |
2.87e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 43.38 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 66 LMAFAAGFVVRPFgalVFGRLGDMIGRKYTFLVTIILMGVATFcvgLLPTYASIGIAApiiLIVLRMLQGLALGGEYGGA 145
Cdd:cd17318 62 LSSFFYGYILTQI---PGGYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAM 132
|
90
....*....|....
gi 518659673 146 ATYVAEHAPPGKRG 159
Cdd:cd17318 133 HALWAKWAPPLERS 146
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
79-165 |
7.51e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 42.32 E-value: 7.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 79 GALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLALGGEYGGAATYVAEHAPPGKR 158
Cdd:cd17439 50 GAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKR 121
|
....*..
gi 518659673 159 GLHTSWI 165
Cdd:cd17439 122 GEHLSWL 128
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
69-159 |
7.77e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 42.31 E-value: 7.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 69 FAAGFVVrpfGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYasigiaapIILIVLRMLQGLALGGEYGGAATY 148
Cdd:TIGR00898 136 FFVGVLL---GSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWVQAVVL 204
|
90
....*....|.
gi 518659673 149 VAEHAPPGKRG 159
Cdd:TIGR00898 205 NTEFLPKKQRA 215
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
79-165 |
8.09e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 42.21 E-value: 8.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 79 GALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKR 158
Cdd:cd17440 50 GAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYG--------LFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKR 121
|
....*..
gi 518659673 159 GLHTSWI 165
Cdd:cd17440 122 GEHLSWL 128
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
67-159 |
8.38e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 8.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 67 MAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAAPIIlivlrmlqGLALGGEYGGAA 146
Cdd:cd17325 239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALL--------GLGLGLVFPATL 310
|
90
....*....|...
gi 518659673 147 TYVAEHAPPGKRG 159
Cdd:cd17325 311 ALLADIVPPEGRG 323
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
197-327 |
9.55e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.68 E-value: 9.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 197 RIPFLFSIVLLGISTWirmslhesPAFLKMKE----EGKACKAPIRESFG----------KWENLKVVLIA-LFSINGGQ 261
Cdd:COG2270 184 RISFLLTALWWLLFAL--------PLFLFLPErprpGPAPPRGAVRAGFRelrrtlrelrRYRDLLRFLLAyFFYRDGVQ 255
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518659673 262 AVTFYAAQFyvlffLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKVGRKPVLMLGLLLATA 327
Cdd:COG2270 256 TVIAFAGIY-----AAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIV 316
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
79-165 |
9.77e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 41.71 E-value: 9.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 79 GALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKR 158
Cdd:cd17363 50 GAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYG--------FFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKR 121
|
....*..
gi 518659673 159 GLHTSWI 165
Cdd:cd17363 122 GEHLSWL 128
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
79-165 |
1.04e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 79 GALVFGRLGDMIGRKYTFlvtiiLMGVATFCVGLLPTYASIGiaaPIILIVLRMLQGLALGGEYGGAATYVAEHAPPGKR 158
Cdd:cd17502 46 FQPIYGKLSDLFGRKWVL-----LIAIVIFELGSLLCGLAPN---MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRER 117
|
....*..
gi 518659673 159 GLHTSWI 165
Cdd:cd17502 118 GKYQGYI 124
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
252-333 |
1.47e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.05 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 252 IALFSINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLIISVVIGAPFFILFGWLSDKV-----GRKPVLMLGLLLAT 326
Cdd:cd17332 2 IGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLA 81
|
....*..
gi 518659673 327 ALYFPIF 333
Cdd:cd17332 82 LLFVLLF 88
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
58-327 |
3.67e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.86 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 58 DTTAFIFALMAFAAGFVvrpFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASigiaapiiLIVLRMLQGLA 137
Cdd:cd17319 36 SPTQYGLIASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 138 LGGEYGGAATYVAEHAPPGKRGLHTS-WIQSTATLGLLLSLLVVLAcryftgdqFEVWGWRIPFLFS---IVLLGISTWI 213
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGlFNSGAPLGAAIGPPLSGWL--------LLLFGWRWAFIIEgllGLLLAVLWWF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 214 rmslhespaFLKMkeegkackapiresfgkwenlkvvLIALFSINGGQAVTFYAAQFYVLFFLTQFLRMDPALANMLLII 293
Cdd:cd17319 177 ---------YLRQ------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAI 223
|
250 260 270
....*....|....*....|....*....|....*..
gi 518659673 294 SVVIGAPFFILFGWLSDKV---GRKPVLMLGLLLATA 327
Cdd:cd17319 224 PFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAV 260
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
79-165 |
3.85e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.91 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 79 GALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYAsigiaapiILIVLRMLQGLALGGEYGGAATYVAEHAPPGKR 158
Cdd:cd17438 50 GAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREKR 121
|
....*..
gi 518659673 159 GLHTSWI 165
Cdd:cd17438 122 GEHLSWL 128
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
52-167 |
4.15e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 52 FFAGVNDTTAFIFALMAFAAGFVVrPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAApiilivlr 131
Cdd:cd17473 223 LLQERGGGSAALIGLALAIASLAG-AIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGA-------- 293
|
90 100 110
....*....|....*....|....*....|....*.
gi 518659673 132 MLQGLALGGEYGGAATYVAEHAPPGKRGLHTSWIQS 167
Cdd:cd17473 294 ILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
61-159 |
7.64e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 7.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 61 AFIFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAApiilivlrMLQGLALGG 140
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF--------ILWGLYMGA 303
|
90
....*....|....*....
gi 518659673 141 EYGGAATYVAEHAPPGKRG 159
Cdd:cd17370 304 QESIERAAVADLVPAELRG 322
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
55-165 |
7.83e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.70 E-value: 7.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 55 GVNDTTAFIFALMAFAAGFVvrpfGALVFGRLGDMIGR--KYTFLVTIILMGVATFCVGLLPTyasigiaaPIILIVLRM 132
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIV----GSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPS--------PALAIALLF 279
|
90 100 110
....*....|....*....|....*....|...
gi 518659673 133 LQGLALGGEYGGAATYVAEHAPPGKRGLHTSWI 165
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLV 312
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
63-168 |
8.04e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 8.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 63 IFALMAFAAGFVVRPFGALVFGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYASIGIAAPIILIVlrmlqGLALGGEY 142
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL-----GFGFGLVF 309
|
90 100
....*....|....*....|....*.
gi 518659673 143 GGAATYVAEHAPPGKRGLHTSWIQST 168
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTA 335
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
38-165 |
8.95e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 8.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518659673 38 FFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAGfVVRPFGalvfGRLGDMIGRKYTFLVTIILMGVATFCVGLLPTYA 117
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA-LGRPLG----GWLSDRIGGRRVLLIVFALMALGLLLLALALGSL 295
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 518659673 118 SIGIAAPIILivlrmlqGLALGGEYGGAATYVAEHAPPGKRGLHTSWI 165
Cdd:COG2223 296 WLFLVLFLLL-------GLALGGGNGAVFALVPDIFPTKNAGAVYGLV 336
|
|
| |
