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MULTISPECIES: penicillin-binding protein 2 [Staphylococcus]
Protein Classification
peptidoglycan D,D-transpeptidase FtsI family protein ( domain architecture ID 11433609 )
peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
36-677
4.17e-115
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 357.60
E-value: 4.17e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 36 V V L RL G YLQ IAQ G SH Y KQ L IKNDENI TV NESV PRG R I L DRNG K VL VD N ASKM S ITYTRNR kts Q K EMLN TA K KL TD L IKM 115
Cdd:COG0768 28 L V G RL F YLQ VVE G DE Y AE L AEENRIR TV PIPA PRG L I Y DRNG N VL AT N VPVY S LYADPEE --- V K DPEE TA E KL AK L LGL 104
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 116 D TDKITERD KK D fwiqmypssakklm RKE qlmledgsisqdqfdtqlrdkiekkqlkqltkkdlqvlaiyremnagstld 195
Cdd:COG0768 105 D PEELRKKL KK K -------------- SRF --------------------------------------------------- 119
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 196 P QTI K n EDV S EK E Y A AV sq QLS KLPGV NTTMDWD R K YPYG DTLRGIF G D V ST stegipkelteqylskg YSRN D RV GKS Y 275
Cdd:COG0768 120 P VYL K - RNL S PE E A A RI -- RAL KLPGV YVEAEYK R Y YPYG ELAAHVL G Y V GE ----------------- INGG D GI GKS G 179
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 276 LE YQ YED V L K GT KKQMKYTT D KS GRVI - SSEVLN P GSR G H DL Q LTID I DLQK KV E SL L E K QISKLRSQGA kdmdn A L m VV 354
Cdd:COG0768 180 LE KA YED L L R GT PGKRRVEV D AR GRVI r DLGEEK P PVP G K DL V LTID S DLQK IA E EA L K K AVEEYKAKSG ----- A V - VV 253
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 355 QN PK N G D ILA I A GK qidkqgkl KDY D IGN F ------------- TAQ Y TV GS SV K GG T LL A GYQNKA I NV g E T MV D E P LKF 421
Cdd:COG0768 254 MD PK T G E ILA M A SY -------- PSF D PNL F vggpdeplrnrav QGT Y EP GS TF K PF T AA A ALEEGV I TP - D T TF D C P GYY 324
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 422 Q - GG L T K R SY f NKN GH VSIDDKQ AL MH SSNV YMF K T AL K L AG D pytsgmslpnniadagr KL RKG L NQV GLG L KTGIDLP 500
Cdd:COG0768 325 R v GG R T I R DW - DRG GH GTLTLTE AL AK SSNV GFY K L AL R L GI D ----------------- KL YDY L KKF GLG Q KTGIDLP 386
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 501 N E TP G QIEPLTN - N PG NYLDLA IGQ YDTY TPLQL S Q YVST IAN D G YRIQ PH IGLS I YESTNK de TGPLKRKIKGN V LNK v 579
Cdd:COG0768 387 G E AS G LLPSPKR w Y PG ETATMS IGQ GLSV TPLQL A Q AYAA IAN G G VLVK PH LVKE I VDPDGE -- VVKEEPEVLRR V ISP - 463
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 580 nnsn DEIKE V Q EG FKMAF NE KQ GT GYAS f RNTVVPS AGKTGTA E V F ----- QDGEP R VNSTYI G Y AP V D D P KLSFSI V YT 654
Cdd:COG0768 464 ---- ETAET V R EG MEGVV NE PG GT ARRA - AIPGYRV AGKTGTA Q V V digng GYYKG R HIASFV G F AP A D N P RYAVAV V VE 538
650 660
....*....|....*....|....*..
gi 518673264 655 N qpv P PPWLN GG D ---- LG R DVINY Y F 677
Cdd:COG0768 539 N --- P GGGAY GG T vaap VF R EIMEA Y L 562
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
36-677
4.17e-115
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 357.60
E-value: 4.17e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 36 V V L RL G YLQ IAQ G SH Y KQ L IKNDENI TV NESV PRG R I L DRNG K VL VD N ASKM S ITYTRNR kts Q K EMLN TA K KL TD L IKM 115
Cdd:COG0768 28 L V G RL F YLQ VVE G DE Y AE L AEENRIR TV PIPA PRG L I Y DRNG N VL AT N VPVY S LYADPEE --- V K DPEE TA E KL AK L LGL 104
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 116 D TDKITERD KK D fwiqmypssakklm RKE qlmledgsisqdqfdtqlrdkiekkqlkqltkkdlqvlaiyremnagstld 195
Cdd:COG0768 105 D PEELRKKL KK K -------------- SRF --------------------------------------------------- 119
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 196 P QTI K n EDV S EK E Y A AV sq QLS KLPGV NTTMDWD R K YPYG DTLRGIF G D V ST stegipkelteqylskg YSRN D RV GKS Y 275
Cdd:COG0768 120 P VYL K - RNL S PE E A A RI -- RAL KLPGV YVEAEYK R Y YPYG ELAAHVL G Y V GE ----------------- INGG D GI GKS G 179
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 276 LE YQ YED V L K GT KKQMKYTT D KS GRVI - SSEVLN P GSR G H DL Q LTID I DLQK KV E SL L E K QISKLRSQGA kdmdn A L m VV 354
Cdd:COG0768 180 LE KA YED L L R GT PGKRRVEV D AR GRVI r DLGEEK P PVP G K DL V LTID S DLQK IA E EA L K K AVEEYKAKSG ----- A V - VV 253
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 355 QN PK N G D ILA I A GK qidkqgkl KDY D IGN F ------------- TAQ Y TV GS SV K GG T LL A GYQNKA I NV g E T MV D E P LKF 421
Cdd:COG0768 254 MD PK T G E ILA M A SY -------- PSF D PNL F vggpdeplrnrav QGT Y EP GS TF K PF T AA A ALEEGV I TP - D T TF D C P GYY 324
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 422 Q - GG L T K R SY f NKN GH VSIDDKQ AL MH SSNV YMF K T AL K L AG D pytsgmslpnniadagr KL RKG L NQV GLG L KTGIDLP 500
Cdd:COG0768 325 R v GG R T I R DW - DRG GH GTLTLTE AL AK SSNV GFY K L AL R L GI D ----------------- KL YDY L KKF GLG Q KTGIDLP 386
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 501 N E TP G QIEPLTN - N PG NYLDLA IGQ YDTY TPLQL S Q YVST IAN D G YRIQ PH IGLS I YESTNK de TGPLKRKIKGN V LNK v 579
Cdd:COG0768 387 G E AS G LLPSPKR w Y PG ETATMS IGQ GLSV TPLQL A Q AYAA IAN G G VLVK PH LVKE I VDPDGE -- VVKEEPEVLRR V ISP - 463
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 580 nnsn DEIKE V Q EG FKMAF NE KQ GT GYAS f RNTVVPS AGKTGTA E V F ----- QDGEP R VNSTYI G Y AP V D D P KLSFSI V YT 654
Cdd:COG0768 464 ---- ETAET V R EG MEGVV NE PG GT ARRA - AIPGYRV AGKTGTA Q V V digng GYYKG R HIASFV G F AP A D N P RYAVAV V VE 538
650 660
....*....|....*....|....*..
gi 518673264 655 N qpv P PPWLN GG D ---- LG R DVINY Y F 677
Cdd:COG0768 539 N --- P GGGAY GG T vaap VF R EIMEA Y L 562
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
36-677
6.82e-94
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 302.90
E-value: 6.82e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 36 VVL RL G YLQ IAQ G SH Y KQ L ik NDE N ITVNESV P -- RG R ILDRNG KV L V DN ASKM S ITYTRNRKTSQKEM L NTAK KL T D li 113
Cdd:TIGR03423 17 LAA RL F YLQ VIR G EE Y AT L -- SED N RIRLVPI P pp RG L ILDRNG VL L A DN RPSF S LEIVPEKVDDLDAT L DRLA KL L D -- 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 114 kmdtdk ITER D KKD F wiqmypssakklmrkeqlmledgsisqdqfdtqlrdkiekkqlkqltkkdlqvlai YR E MNAGST 193
Cdd:TIGR03423 93 ------ LDPE D IAR F -------------------------------------------------------- LK E LKRSRR 110
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 194 LD P QTI K n E D VS E K E Y A AVSQQLSK LPGV NTTMDWD R K YPYG DTLRGIF G D V S tstegipk E LT E QY L SK ---- G Y SRN D 269
Cdd:TIGR03423 111 FE P IPL K - S D LT E E E V A RFAVNQYR LPGV EIEARLK R Y YPYG ELAAHVL G Y V G -------- E IN E ED L ER lepa N Y AGG D 181
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 270 RV GKS YL E YQ YED V L K G TKKQMKYTTDKS GRVI ss EV L N -- P GSR G H DL Q LTID ID LQ KKV E SL L EKQI sklrsq GA kdm 347
Cdd:TIGR03423 182 YI GKS GI E KY YED E L R G KPGYREVEVNAR GRVI -- RT L S rv P PVP G K DL V LTID AR LQ QAA E KA L GGRR ------ GA --- 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 348 dnal M VV QN P KN G D ILA IA ---------- GKQ I DK qgkl KDY DIGN ----------- FTAQ Y TV GS SV K GGTL LA GYQNK 406
Cdd:TIGR03423 251 ---- V VV MD P RT G E ILA MV stpsfdpnlf VDG I SS ---- KDY KALL ndpdrpllnra IQGV Y PP GS TF K PVVA LA ALEEG 322
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 407 A I NVGETMVD e P LK FQ - GG ltk R SY -- FNKN GH VSI D DKQ A LMH S SN VY MFKT AL K L agdpyts G M slp NN IA DAGRKL r 483
Cdd:TIGR03423 323 V I TPETRIYC - P GY FQ l GG --- R RF rc WKRG GH GRV D LRK A IEE S CD VY FYQL AL R L ------- G I --- DK IA EYAKRF - 387
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 484 kglnqv G L G L KTGIDLP N E TP G QI ----------- E P LT nn PG NY L DLA IGQ - Y DTY TPLQL SQYVSTI AN D G YRIQ PH I 551
Cdd:TIGR03423 388 ------ G F G Q KTGIDLP G E KS G LV psrewkrkrfg Q P WY -- PG DT L NVS IGQ g Y VLV TPLQL AVATAAL AN G G KLYK PH L 459
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 552 GL SI YESTNK detgp LK R KIKGN VL NKVNN S NDEIKE V Q EG FKMAF N EKQ GT GYASFRNTVVPS AGKTGTA E V F --- Q DG 628
Cdd:TIGR03423 460 VK SI EDPDGG ----- VV R RTEPE VL RPLPI S PENLDV V R EG MRDVV N GPG GT ARRARLGLPYKM AGKTGTA Q V V slk Q GE 534
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518673264 629 --------- EP R VNSTYIGY AP V D D PK LSFSIVYTNQ pvpppwl N GG D ----- LG R DVINY Y F 677
Cdd:TIGR03423 535 kydaeqipe RL R DHALFVAF AP Y D N PK IAVAVIVEHG ------- G GG S saaap IA R KIMDA Y L 590
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
353-655
2.92e-54
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 188.01
E-value: 2.92e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 353 VV QN PK N G DI LA IA GK QI - D KQ G KLKDYDIGNF T AQ Y TV GS SV K GG T L LA GYQ N KAINVG ET MV D E P L K F QGG LTKRSY f 431
Cdd:pfam00905 4 VV LD PK T G EV LA MV GK PS y D PN G FIGPLRNRAV T SR Y EP GS TF K PF T A LA ALD N GVLKPD ET IF D W P G K Q QGG KSIGDW - 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 432 N KNGHVSIDDK QAL MH SSN V YM F K T A L KL AG D pytsgmslpnniadagr KLR KG L NQV G L G L KTGI D LP N E TP G QIE P LT 511
Cdd:pfam00905 83 N QDQVGIGTLR QAL EY SSN W YM Q K L A Q KL GA D ----------------- KLR SY L KKF G Y G N KTGI G LP G E NA G YLT P YW 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 512 NN p G NYLDLA IG qy D T Y TPLQ LS Q YVST IAN D G YRIQ PH IGL SI YESTNKD etgplkrkikgn VLNK VNN S NDEIKE V QE 591
Cdd:pfam00905 146 LE - G ATASFG IG -- L T I TPLQ QA Q AYAA IAN G G KLVP PH LVK SI EDKVDPK ------------ VLNK LPI S KSTAEK V KD 210
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518673264 592 GFKMAF N EKQ GTG Y A SFRNTV V ps AGKTGTA E V F ----- QDGEPRVNSTYI GYAP V D D PK LS F SIVYTN 655
Cdd:pfam00905 211 MLRLVV N DGT GTG T A AVPGYK V -- AGKTGTA Q V A gpkgg GYYDGAQIGWFV GYAP A D N PK YA F AVLIDD 277
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
211-675
1.25e-28
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 121.41
E-value: 1.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 211 AV S Q Q ls KL PGV NTTMDWD R K YPYG DT L RGIF G D VS TSTEGIPKE L TEQYLSKG Y SRNDRV GK SYL E YQ YEDVL K G TKKQ 290
Cdd:PRK10795 148 AV N Q Y -- RF PGV EVKGYQR R Y YPYG SA L THVI G Y VS KINDKDVER L DKEGKLAN Y AATHDI GK LGI E RY YEDVL H G KTGY 225
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 291 MKYTTDKS GRVI SSEVLN P GSR GHD LQ LT I D ID LQ KKV E S LL E kqisklrsq G AK dmdn A LM VV QN P KN G D ILA ------ 364
Cdd:PRK10795 226 EEVEVNNR GRVI RQLHEQ P PQA GHD IY LT L D LK LQ QYI E T LL A --------- G SR ---- A AV VV TD P RT G G ILA lvstps 292
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 365 --------- I AG K qi D KQ G K L K D YD -- IG N FTA Q -- Y TVG S S VK GGTLLAGYQNKA I NVGETMV D e P LKF Q GGLTKRS Y - 430
Cdd:PRK10795 293 ydpnlfvdg I SS K -- D YS G L L N D PN rp LI N RAT Q gv Y PPA S T VK PYVAVSALSAGV I TRNTSLF D - P GWW Q LPGSEKR Y r 369
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 431 - FN K N GH VSIDDKQA L MH S SNVYMFKT A LKLAG D pytsgmslpnniadagr K L RKGLNQV G L G LK TGIDL PN E TP G q IE P 509
Cdd:PRK10795 370 d WK K W GH GRLNVTKS L EE S ADTFFYQV A YDMGI D ----------------- R L SEWMGKF G Y G HY TGIDL AE E RS G - NM P 431
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 510 LTN ---------- NP G NYLDLA IGQ - Y D T Y TP L Q L S QYVS T IA NDG YRIQ PH IGL S IY E STNKD etg P LKRKIKGN V LN k 578
Cdd:PRK10795 432 TRE wkqkrfkkpw YQ G DTIPVG IGQ g Y W T A TP I Q M S KALM T LI NDG IVKV PH LLM S TA E DGKQV --- P WVQPHEPP V GD - 507
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 579 VNNSND EI ke VQE G FKMAF N EKQ GT GYAS F RNTVVPS A G K T GTA E VF QDGE prv N S TY --------------- IGY AP VD 643
Cdd:PRK10795 508 IHSGYW EI -- AKD G MYGVA N RPN GT AHKY F ASAPYKI A A K S GTA Q VF GLKA --- N E TY nahkiaerlrdhklm TAF AP YN 582
490 500 510
....*....|....*....|....*....|..
gi 518673264 644 D P KLSFS I VYT N QPVP P P wln G G DLG R DVINY 675
Cdd:PRK10795 583 N P QVAVA I ILE N GGAG P A --- V G TIM R QILDH 611
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
36-677
4.17e-115
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 357.60
E-value: 4.17e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 36 V V L RL G YLQ IAQ G SH Y KQ L IKNDENI TV NESV PRG R I L DRNG K VL VD N ASKM S ITYTRNR kts Q K EMLN TA K KL TD L IKM 115
Cdd:COG0768 28 L V G RL F YLQ VVE G DE Y AE L AEENRIR TV PIPA PRG L I Y DRNG N VL AT N VPVY S LYADPEE --- V K DPEE TA E KL AK L LGL 104
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 116 D TDKITERD KK D fwiqmypssakklm RKE qlmledgsisqdqfdtqlrdkiekkqlkqltkkdlqvlaiyremnagstld 195
Cdd:COG0768 105 D PEELRKKL KK K -------------- SRF --------------------------------------------------- 119
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 196 P QTI K n EDV S EK E Y A AV sq QLS KLPGV NTTMDWD R K YPYG DTLRGIF G D V ST stegipkelteqylskg YSRN D RV GKS Y 275
Cdd:COG0768 120 P VYL K - RNL S PE E A A RI -- RAL KLPGV YVEAEYK R Y YPYG ELAAHVL G Y V GE ----------------- INGG D GI GKS G 179
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 276 LE YQ YED V L K GT KKQMKYTT D KS GRVI - SSEVLN P GSR G H DL Q LTID I DLQK KV E SL L E K QISKLRSQGA kdmdn A L m VV 354
Cdd:COG0768 180 LE KA YED L L R GT PGKRRVEV D AR GRVI r DLGEEK P PVP G K DL V LTID S DLQK IA E EA L K K AVEEYKAKSG ----- A V - VV 253
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 355 QN PK N G D ILA I A GK qidkqgkl KDY D IGN F ------------- TAQ Y TV GS SV K GG T LL A GYQNKA I NV g E T MV D E P LKF 421
Cdd:COG0768 254 MD PK T G E ILA M A SY -------- PSF D PNL F vggpdeplrnrav QGT Y EP GS TF K PF T AA A ALEEGV I TP - D T TF D C P GYY 324
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 422 Q - GG L T K R SY f NKN GH VSIDDKQ AL MH SSNV YMF K T AL K L AG D pytsgmslpnniadagr KL RKG L NQV GLG L KTGIDLP 500
Cdd:COG0768 325 R v GG R T I R DW - DRG GH GTLTLTE AL AK SSNV GFY K L AL R L GI D ----------------- KL YDY L KKF GLG Q KTGIDLP 386
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 501 N E TP G QIEPLTN - N PG NYLDLA IGQ YDTY TPLQL S Q YVST IAN D G YRIQ PH IGLS I YESTNK de TGPLKRKIKGN V LNK v 579
Cdd:COG0768 387 G E AS G LLPSPKR w Y PG ETATMS IGQ GLSV TPLQL A Q AYAA IAN G G VLVK PH LVKE I VDPDGE -- VVKEEPEVLRR V ISP - 463
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 580 nnsn DEIKE V Q EG FKMAF NE KQ GT GYAS f RNTVVPS AGKTGTA E V F ----- QDGEP R VNSTYI G Y AP V D D P KLSFSI V YT 654
Cdd:COG0768 464 ---- ETAET V R EG MEGVV NE PG GT ARRA - AIPGYRV AGKTGTA Q V V digng GYYKG R HIASFV G F AP A D N P RYAVAV V VE 538
650 660
....*....|....*....|....*..
gi 518673264 655 N qpv P PPWLN GG D ---- LG R DVINY Y F 677
Cdd:COG0768 539 N --- P GGGAY GG T vaap VF R EIMEA Y L 562
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
36-677
6.82e-94
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 302.90
E-value: 6.82e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 36 VVL RL G YLQ IAQ G SH Y KQ L ik NDE N ITVNESV P -- RG R ILDRNG KV L V DN ASKM S ITYTRNRKTSQKEM L NTAK KL T D li 113
Cdd:TIGR03423 17 LAA RL F YLQ VIR G EE Y AT L -- SED N RIRLVPI P pp RG L ILDRNG VL L A DN RPSF S LEIVPEKVDDLDAT L DRLA KL L D -- 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 114 kmdtdk ITER D KKD F wiqmypssakklmrkeqlmledgsisqdqfdtqlrdkiekkqlkqltkkdlqvlai YR E MNAGST 193
Cdd:TIGR03423 93 ------ LDPE D IAR F -------------------------------------------------------- LK E LKRSRR 110
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 194 LD P QTI K n E D VS E K E Y A AVSQQLSK LPGV NTTMDWD R K YPYG DTLRGIF G D V S tstegipk E LT E QY L SK ---- G Y SRN D 269
Cdd:TIGR03423 111 FE P IPL K - S D LT E E E V A RFAVNQYR LPGV EIEARLK R Y YPYG ELAAHVL G Y V G -------- E IN E ED L ER lepa N Y AGG D 181
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 270 RV GKS YL E YQ YED V L K G TKKQMKYTTDKS GRVI ss EV L N -- P GSR G H DL Q LTID ID LQ KKV E SL L EKQI sklrsq GA kdm 347
Cdd:TIGR03423 182 YI GKS GI E KY YED E L R G KPGYREVEVNAR GRVI -- RT L S rv P PVP G K DL V LTID AR LQ QAA E KA L GGRR ------ GA --- 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 348 dnal M VV QN P KN G D ILA IA ---------- GKQ I DK qgkl KDY DIGN ----------- FTAQ Y TV GS SV K GGTL LA GYQNK 406
Cdd:TIGR03423 251 ---- V VV MD P RT G E ILA MV stpsfdpnlf VDG I SS ---- KDY KALL ndpdrpllnra IQGV Y PP GS TF K PVVA LA ALEEG 322
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 407 A I NVGETMVD e P LK FQ - GG ltk R SY -- FNKN GH VSI D DKQ A LMH S SN VY MFKT AL K L agdpyts G M slp NN IA DAGRKL r 483
Cdd:TIGR03423 323 V I TPETRIYC - P GY FQ l GG --- R RF rc WKRG GH GRV D LRK A IEE S CD VY FYQL AL R L ------- G I --- DK IA EYAKRF - 387
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 484 kglnqv G L G L KTGIDLP N E TP G QI ----------- E P LT nn PG NY L DLA IGQ - Y DTY TPLQL SQYVSTI AN D G YRIQ PH I 551
Cdd:TIGR03423 388 ------ G F G Q KTGIDLP G E KS G LV psrewkrkrfg Q P WY -- PG DT L NVS IGQ g Y VLV TPLQL AVATAAL AN G G KLYK PH L 459
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 552 GL SI YESTNK detgp LK R KIKGN VL NKVNN S NDEIKE V Q EG FKMAF N EKQ GT GYASFRNTVVPS AGKTGTA E V F --- Q DG 628
Cdd:TIGR03423 460 VK SI EDPDGG ----- VV R RTEPE VL RPLPI S PENLDV V R EG MRDVV N GPG GT ARRARLGLPYKM AGKTGTA Q V V slk Q GE 534
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518673264 629 --------- EP R VNSTYIGY AP V D D PK LSFSIVYTNQ pvpppwl N GG D ----- LG R DVINY Y F 677
Cdd:TIGR03423 535 kydaeqipe RL R DHALFVAF AP Y D N PK IAVAVIVEHG ------- G GG S saaap IA R KIMDA Y L 590
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
353-655
2.92e-54
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 188.01
E-value: 2.92e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 353 VV QN PK N G DI LA IA GK QI - D KQ G KLKDYDIGNF T AQ Y TV GS SV K GG T L LA GYQ N KAINVG ET MV D E P L K F QGG LTKRSY f 431
Cdd:pfam00905 4 VV LD PK T G EV LA MV GK PS y D PN G FIGPLRNRAV T SR Y EP GS TF K PF T A LA ALD N GVLKPD ET IF D W P G K Q QGG KSIGDW - 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 432 N KNGHVSIDDK QAL MH SSN V YM F K T A L KL AG D pytsgmslpnniadagr KLR KG L NQV G L G L KTGI D LP N E TP G QIE P LT 511
Cdd:pfam00905 83 N QDQVGIGTLR QAL EY SSN W YM Q K L A Q KL GA D ----------------- KLR SY L KKF G Y G N KTGI G LP G E NA G YLT P YW 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 512 NN p G NYLDLA IG qy D T Y TPLQ LS Q YVST IAN D G YRIQ PH IGL SI YESTNKD etgplkrkikgn VLNK VNN S NDEIKE V QE 591
Cdd:pfam00905 146 LE - G ATASFG IG -- L T I TPLQ QA Q AYAA IAN G G KLVP PH LVK SI EDKVDPK ------------ VLNK LPI S KSTAEK V KD 210
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518673264 592 GFKMAF N EKQ GTG Y A SFRNTV V ps AGKTGTA E V F ----- QDGEPRVNSTYI GYAP V D D PK LS F SIVYTN 655
Cdd:pfam00905 211 MLRLVV N DGT GTG T A AVPGYK V -- AGKTGTA Q V A gpkgg GYYDGAQIGWFV GYAP A D N PK YA F AVLIDD 277
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
67-303
8.67e-38
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 138.61
E-value: 8.67e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 67 V PRG R I L DRNG K VL VD N ASKM S I T Y T RN --- RKTSQ K EM L NT AK K L TDLIKM D TDKI TER dkkdfwiqmypssakklmrk 143
Cdd:pfam03717 4 A PRG E I Y DRNG V VL AT N KPVY S L T I T PS klk KADAL K TA L KL AK L L SNYEDL D DEDL TER -------------------- 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 144 eqlmledgsisqdqfdtqlrdkiekkqlkqltkkdlqvlai YRE MN AGSTLD P QT IK n EDV SE K E Y A AVSQQ L SK LPGV N 223
Cdd:pfam03717 64 ----------------------------------------- FLK MN SYKSYY P VV IK - KNL SE E E V A RIEEN L LE LPGV S 101
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 224 TTM D WD R K YPYG DTLRGIF G D V STS TE GIP kelt E Q YL S KGYSR N D R VGKS Y LE Y QYE D VL K G TKKQMKYTT D KS GRVI S 303
Cdd:pfam03717 102 IET D PV R Y YPYG ELAAHLL G Y V GEI TE EEL ---- E K YL D KGYSR G D L VGKS G LE K QYE S VL R G KDGVRQVEV D AL GRVI R 177
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
211-675
1.25e-28
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 121.41
E-value: 1.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 211 AV S Q Q ls KL PGV NTTMDWD R K YPYG DT L RGIF G D VS TSTEGIPKE L TEQYLSKG Y SRNDRV GK SYL E YQ YEDVL K G TKKQ 290
Cdd:PRK10795 148 AV N Q Y -- RF PGV EVKGYQR R Y YPYG SA L THVI G Y VS KINDKDVER L DKEGKLAN Y AATHDI GK LGI E RY YEDVL H G KTGY 225
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 291 MKYTTDKS GRVI SSEVLN P GSR GHD LQ LT I D ID LQ KKV E S LL E kqisklrsq G AK dmdn A LM VV QN P KN G D ILA ------ 364
Cdd:PRK10795 226 EEVEVNNR GRVI RQLHEQ P PQA GHD IY LT L D LK LQ QYI E T LL A --------- G SR ---- A AV VV TD P RT G G ILA lvstps 292
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 365 --------- I AG K qi D KQ G K L K D YD -- IG N FTA Q -- Y TVG S S VK GGTLLAGYQNKA I NVGETMV D e P LKF Q GGLTKRS Y - 430
Cdd:PRK10795 293 ydpnlfvdg I SS K -- D YS G L L N D PN rp LI N RAT Q gv Y PPA S T VK PYVAVSALSAGV I TRNTSLF D - P GWW Q LPGSEKR Y r 369
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 431 - FN K N GH VSIDDKQA L MH S SNVYMFKT A LKLAG D pytsgmslpnniadagr K L RKGLNQV G L G LK TGIDL PN E TP G q IE P 509
Cdd:PRK10795 370 d WK K W GH GRLNVTKS L EE S ADTFFYQV A YDMGI D ----------------- R L SEWMGKF G Y G HY TGIDL AE E RS G - NM P 431
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 510 LTN ---------- NP G NYLDLA IGQ - Y D T Y TP L Q L S QYVS T IA NDG YRIQ PH IGL S IY E STNKD etg P LKRKIKGN V LN k 578
Cdd:PRK10795 432 TRE wkqkrfkkpw YQ G DTIPVG IGQ g Y W T A TP I Q M S KALM T LI NDG IVKV PH LLM S TA E DGKQV --- P WVQPHEPP V GD - 507
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 579 VNNSND EI ke VQE G FKMAF N EKQ GT GYAS F RNTVVPS A G K T GTA E VF QDGE prv N S TY --------------- IGY AP VD 643
Cdd:PRK10795 508 IHSGYW EI -- AKD G MYGVA N RPN GT AHKY F ASAPYKI A A K S GTA Q VF GLKA --- N E TY nahkiaerlrdhklm TAF AP YN 582
490 500 510
....*....|....*....|....*....|..
gi 518673264 644 D P KLSFS I VYT N QPVP P P wln G G DLG R DVINY 675
Cdd:PRK10795 583 N P QVAVA I ILE N GGAG P A --- V G TIM R QILDH 611
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
319-641
7.06e-25
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 110.01
E-value: 7.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 319 T I D ID LQK KV E SLLEKQISK lrsq G AKDMDN A LM VV QN PK N G DI LA IA G kqidkq G K lk DY DIGN F ---- T A QYTV GS SV 394
Cdd:COG0744 300 T L D PK LQK AA E KAVKNVLPE ---- G KPGGLQ A AL VV VD PK T G EV LA MV G ------ G R -- DY GKSQ F nrat Q A KRQP GS TF 367
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 395 K GGTLL A GYQNK a INVGE T MV DEP LK F Q GG LTKRSYFNKNGHVSIDDKQ AL MH S S N VYMFKT A LKL agdpyts G msl PNN 474
Cdd:COG0744 368 K PFVYA A ALEQG - YTPAT T VD DEP VT F P GG GWSPKNYDGRYRGPVTLRE AL AN S L N TPAVRL A QEV ------- G --- LDK 436
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 475 IA D AG R K L rkglnqvglglkt GI D lpnetpgqi E PL TN NP G nyld LA I G QYDT y T PL QLSQYVS T I AN D G YRIQ PH IGLS 554
Cdd:COG0744 437 VV D TA R R L ------------- GI T --------- S PL DP NP S ---- LA L G TSEV - S PL EMASAYA T F AN G G VYVE PH AITK 489
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 555 IYESTN K --- DETGPLKRK I KGN V lnk VNNSN D EIKE V QEG fkmafnekq GTG Y - A SFRN tv V P S AGKTGT AEVFQ D gep 630
Cdd:COG0744 490 VTDADG K vly EAKPKCEQV I SPE V --- AYLMT D MLQD V VTS --------- GTG R a A RLPG -- R P V AGKTGT TNDNR D --- 552
330
....*....|.
gi 518673264 631 rvn STYI GY A P 641
Cdd:COG0744 553 --- AWFV GY T P 560
PBP_1a_fam
TIGR02074 penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
313-641
4.15e-15
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain]
Cd Length: 531
Bit Score: 78.84
E-value: 4.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 313 G HDLQL T I D I D L QK KV E SL L EKQISKLRSQGAK D M d N A LM V VQN P KN G DIL A IA G K qidkqgkl K DY DIGN F ---- T A QY 388
Cdd:TIGR02074 221 G LKIYT T L D L D A QK AA E KV L NTGLRVAGRRDGD D L - Q A AL V AID P DT G AVR A LV G G -------- R DY GKSQ F nrat Q A KR 291
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 389 TV GS SV K GGTLL A gyqnk A INV G E T M ---- V DEP LKFQ G G ltk RSYFN KN ------ G H V SI dd K QAL MH S S N VYMFKTAL 458
Cdd:TIGR02074 292 QP GS TF K PFVYA A ----- A LEK G L T P ativ N DEP ITYN G N --- GPWSP KN ygggyr G N V TL -- R QAL AQ S R N IPAVRLLQ 361
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 459 KLAG D P ytsgmslpnn IADAGRKL rkglnqvglglkt GI dlpnetpgqiepl T NNPGNY L D LA I G QYDT y T PL QLSQYVS 538
Cdd:TIGR02074 362 EVGL D K ---------- VVALAKRF ------------- GI ------------- T SPLDPV L S LA L G TVEV - S PL EMASAYA 404
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673264 539 TI AN D G YRIQ PH IGLS I YEST nkdetgplkrkik G N V LNKVNNSNDEIKEVQEGFK M AFNE K Q ---- GTG YAS f R NTVV P 614
Cdd:TIGR02074 405 VF AN G G KYVE PH GIRK I VDRD ------------- G K V IYENKPKTTQVISPATAYI M TDML K G vves GTG RSA - R LPGR P 470
330 340
....*....|....*....|....*..
gi 518673264 615 S AGKTGT AEVFQ D geprvn STYI GY A P 641
Cdd:TIGR02074 471 V AGKTGT TQNWR D ------ AWFV GY T P 491
PbpC
COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
306-367
5.44e-04
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain]
Cd Length: 773
Bit Score: 43.28
E-value: 5.44e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518673264 306 V L NPGSR G HDLQL T I D ID LQ KKV E S L LEKQISK L RSQ G AKDM dn A LM VV Q N p KN G DI LA IA G 367
Cdd:COG4953 264 L L RQLPG G TRIRT T L D AG LQ RRL E R L VRRYVRR L KQN G IHNA -- A VL VV D N - RT G EV LA YV G 322
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
