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Conserved domains on  [gi|518673963|ref|WP_019835656|]
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MULTISPECIES: NAD kinase [Staphylococcus]

Protein Classification

NAD kinase( domain architecture ID 10012226)

ATP-dependent NAD kinase catalyzes the phosphorylation of NAD to NADP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-267 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


:

Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 500.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963   1 MRYTILSKGDSKSNTLKHKMMNQMNSFHMMEDTENPEIVISVGGDGTLLQAFHQYSHMLSNVAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  81 HEVEKLIDEIHHSEFQVIEYPLLEIIVKYNNTKNETrYLALNEATMKTENGsTLVADVAIRGKHFERFRGDGLCISTPSG 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEG-TLVADVYINGVLFERFRGDGLCVSTPTG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 161 STAYNKALGGALIHPSLEAIQIAEIASINNRVFRTVGSPLVLPKHHTCLITPVNHNTIRTTIDHVSLKHKNVSDIQFRVA 240
Cdd:PRK04885 159 STAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVA 238

                        250       260
                 ....*....|....*....|....*..
gi 518673963 241 NEKVRFARFRPFPFWKRVHDSFIESED 267
Cdd:PRK04885 239 NEKIRFARFRHFPFWKRVKDSFIGEVE 265
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-267 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 500.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963   1 MRYTILSKGDSKSNTLKHKMMNQMNSFHMMEDTENPEIVISVGGDGTLLQAFHQYSHMLSNVAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  81 HEVEKLIDEIHHSEFQVIEYPLLEIIVKYNNTKNETrYLALNEATMKTENGsTLVADVAIRGKHFERFRGDGLCISTPSG 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEG-TLVADVYINGVLFERFRGDGLCVSTPTG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 161 STAYNKALGGALIHPSLEAIQIAEIASINNRVFRTVGSPLVLPKHHTCLITPVNHNTIRTTIDHVSLKHKNVSDIQFRVA 240
Cdd:PRK04885 159 STAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVA 238

                        250       260
                 ....*....|....*....|....*..
gi 518673963 241 NEKVRFARFRPFPFWKRVHDSFIESED 267
Cdd:PRK04885 239 NEKIRFARFRHFPFWKRVKDSFIGEVE 265
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
31-267 8.37e-80

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 241.96  E-value: 8.37e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  31 EDTENPEIVISVGGDGTLLQAFHQYSHmlSNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIEYPLLEIIVKYN 110
Cdd:COG0061   48 ELGEEADLVIVLGGDGTLLRAARLLAP--LGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 111 NtKNETRYLALNEATMKTEN-GSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIASIN 189
Cdd:COG0061  126 G-EVVHEALALNEVVVLRGSiARMIELEVYIDGEFLEEFRGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHT 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 190 NRVfrtvgSPLVLPKHHTCLITPVNHN-TIRTTIDH-VSLKHKNVSDIQFRVANEKVRFARFRPFPFWKRVHDSFIESED 267
Cdd:COG0061  205 LSS-----RPLVLPDDSEIEIEVLEDSrPAVLVADGqEVRDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKLGWGGD 279
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-248 3.43e-11

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 59.24  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  121 LNEATMKTENGSTLVA-DVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIASINNRvFRtvgsP 199
Cdd:pfam20143   1 LNEVVYVRGPGATMIEfELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLS-SR----P 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 518673963  200 LVLPKHHTCLITPVN-HNTIRTTIDHVSLKHKNVSDIQFRVANEKVRFAR 248
Cdd:pfam20143  76 IVVSSSSKLRIRVLSrAEALLVDDGDPELDISPGDRVRVRKSYYKAKFIR 125
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-267 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 500.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963   1 MRYTILSKGDSKSNTLKHKMMNQMNSFHMMEDTENPEIVISVGGDGTLLQAFHQYSHMLSNVAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885   1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  81 HEVEKLIDEIHHSEFQVIEYPLLEIIVKYNNTKNETrYLALNEATMKTENGsTLVADVAIRGKHFERFRGDGLCISTPSG 160
Cdd:PRK04885  81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEG-TLVADVYINGVLFERFRGDGLCVSTPTG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 161 STAYNKALGGALIHPSLEAIQIAEIASINNRVFRTVGSPLVLPKHHTCLITPVNHNTIRTTIDHVSLKHKNVSDIQFRVA 240
Cdd:PRK04885 159 STAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVA 238

                        250       260
                 ....*....|....*....|....*..
gi 518673963 241 NEKVRFARFRPFPFWKRVHDSFIESED 267
Cdd:PRK04885 239 NEKIRFARFRHFPFWKRVKDSFIGEVE 265
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
31-267 8.37e-80

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 241.96  E-value: 8.37e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  31 EDTENPEIVISVGGDGTLLQAFHQYSHmlSNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIEYPLLEIIVKYN 110
Cdd:COG0061   48 ELGEEADLVIVLGGDGTLLRAARLLAP--LGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 111 NtKNETRYLALNEATMKTEN-GSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIASIN 189
Cdd:COG0061  126 G-EVVHEALALNEVVVLRGSiARMIELEVYIDGEFLEEFRGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHT 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 190 NRVfrtvgSPLVLPKHHTCLITPVNHN-TIRTTIDH-VSLKHKNVSDIQFRVANEKVRFARFRPFPFWKRVHDSFIESED 267
Cdd:COG0061  205 LSS-----RPLVLPDDSEIEIEVLEDSrPAVLVADGqEVRDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKLGWGGD 279
ppnK PRK03501
NAD kinase;
25-263 9.12e-56

NAD kinase;


Pssm-ID: 179584  Cd Length: 264  Bit Score: 180.17  E-value: 9.12e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  25 NSFHMMEDTENPEIVISVGGDGTLLQAFHQySHMLSNVAFVGVHT-GHLGFYADWLPHEVEKLIDEIHHSEFQVIEYPLL 103
Cdd:PRK03501  29 YGFTVVDHPKNANIIVSIGGDGTFLQAVRK-TGFREDCLYAGISTkDQLGFYCDFHIDDLDKMIQAITKEEIEVRKYPTI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 104 EIIVKynntkNETRYLALNEATMKTENGSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIA 183
Cdd:PRK03501 108 EVTVD-----GSTSFYCLNEFSIRSSIIKTFVIDVYIDDLHFETFRGDGMVVSTPTGSTAYNKSVRGAVVDPLIPCFQVS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 184 EIASINNRVFRTVGSPLVLPKHHTCLITPV---NHNTIrTTIDHVSLKHKNVSDIQFRVANEKVRFARFRPFPFWKRVHD 260
Cdd:PRK03501 183 ELASLNNNTYRTLGSPFILSHERKLTLKIVqdgNDYPI-IGMDNEALSIKHVEKIDIRLSDKQIKTVKLKDNSFWEKVKR 261


                 ...
gi 518673963 261 SFI 263
Cdd:PRK03501 262 TFL 264
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 18-203 5.28e-32

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 119.26  E-value: 5.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  18 HKMMNQMNSFHMMEDT--------ENPEIVISVGGDGTLLQAFHQYSHmlSNVAFVGVHTGHLGFYADWLPHEVEKLIDE 89
Cdd:PRK01911  39 LDFLKQDLKFHPSYDTfsdneeldGSADMVISIGGDGTFLRTATYVGN--SNIPILGINTGRLGFLATVSKEEIEETIDE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  90 IHHSEFQVIEYPLLEIIVKYNNTKNETryLALNEATM-KTENGSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKAL 168
Cdd:PRK01911 117 LLNGDYTIEERSLLQLESNPKLFGELN--FALNEIAIlKRDTSSMITVHTYLNGEYLNSYWADGLIVATPTGSTGYSLSC 194

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 518673963 169 GGALIHPSLEAIQIAEIA--SINNRvfrtvgsPLVLP 203
Cdd:PRK01911 195 GGPIIVPDAKSFVITPIAphNLNVR-------PLVIP 224
pnk PRK14077
NAD(+) kinase;
25-248 1.17e-31

NAD(+) kinase;


Pssm-ID: 172567 [Multi-domain]  Cd Length: 287  Bit Score: 118.34  E-value: 1.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  25 NSFHMMEDTENPEIVISVGGDGTLLQAFHQYSHmlSNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQvIEYP-LL 103
Cdd:PRK14077  54 PGYGLDELFKISDFLISLGGDGTLISLCRKAAE--YDKFVLGIHAGHLGFLTDITVDEAEKFFQAFFQGEFE-IEKPyML 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 104 EIIVKYNNTKNEtRYLALNEAT-MKTENGSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQI 182
Cdd:PRK14077 131 SVFLEKKQGKIL-EKLAFNDVViSKNNQASMAHIEAFLNEKYFNEYFGDGVIVATPAGSTAYNMSANGPIIYPLSQVFIL 209

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518673963 183 AEIA--SINNRvfrtvgsPLVLPKHHTclitpVNhntIRTTIDHVSL-------KHKNVSDIQFRVANEKVRFAR 248
Cdd:PRK14077 210 TPVCshSLTQR-------PIVLPKGFE-----VE---FKTKSDCILCidgqdryKMNDFKSIKVGLSDKNVALIR 269
ppnK PRK00561
NAD(+) kinase;
1-204 1.97e-26

NAD(+) kinase;


Pssm-ID: 100598 [Multi-domain]  Cd Length: 259  Bit Score: 103.80  E-value: 1.97e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963   1 MRYTILSKGDSKSNTLKHKMMNQMNSFHMMEDteNPEIVISVGGDGTLLQAFHQYSHmlSNVAFVGVHTGHLGFYADWlp 80
Cdd:PRK00561   1 MKYKIFASTTPQTEPVLPKLKKVLKKKLAVED--GADYLFVLGGDGFFVSTAANYNC--AGCKVVGINTGHLGFYTSF-- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  81 heVEKLIDEIHHSEFQVIEYPLLEII-VKYNNTKnetrYLALNEATMKTENGSTLvaDVAIRGKHFERFRGDGLCISTPS 159
Cdd:PRK00561  75 --NETDLDQNFANKLDQLKFTQIDLLeVQIDDQI----HLVLNELAVYTNTAYPI--NIFIDNEFWEKYRGSGLLIGPRT 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 518673963 160 GSTAYNKALGGALIHPSLEAIQIAEIASINNRVFRTVGSPLVLPK 204
Cdd:PRK00561 147 GSTALAKSAKGAVIFPRIDVIQIIELNPLLHPNQTTIQSPIILPI 191
ppnK PRK01185
NAD(+) kinase;
35-263 2.53e-23

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 95.65  E-value: 2.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  35 NPEIVISVGGDGTLLQAFhQYSHmlSNVafVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIEYplLEIIVKYNNTKN 114
Cdd:PRK01185  52 NADVIITIGGDGTILRTL-QRAK--GPI--LGINMGGLGFLTEIEIDEVGSAIKKLIRGEYFIDER--MKLKVYINGERL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 115 ETrylALNEATMKTENGSTLVADVAIRGKHF-ERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIASINNRVf 193
Cdd:PRK01185 125 ED---CTNEAVIHTDRIAKIRQFKIYYDGHFlDTFKADGVIVATPTGSTSYSSSAGGPILLPNLEGMVISYIAPYSSRP- 200

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518673963 194 rtvgSPLVLPKHHTCLITPVNHNTIRTTID---HVSLKHKNVSDIqfRVANEKVRFARFRPFPFwKRVHDSFI 263
Cdd:PRK01185 201 ----KSVVVPSESTVEIKIAGDQSSLLILDgqyEYKISKGDTVEI--SKSENYARFISFRESPY-DRIREKLI 266
ppnK PRK02645
NAD(+) kinase;
33-220 1.03e-22

NAD(+) kinase;


Pssm-ID: 179455 [Multi-domain]  Cd Length: 305  Bit Score: 94.59  E-value: 1.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  33 TENPEIVISVGGDGTLLQAFHQYSH----MLS-NVAfvgvhtGHLGFyadwLPHEV-----EKLIDEIHHSEFQVIEYPL 102
Cdd:PRK02645  55 SELIDLAIVLGGDGTVLAAARHLAPhdipILSvNVG------GHLGF----LTHPRdllqdESVWDRLQEDRYAIERRMM 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 103 LEIIV----KYNNTKNETRYLALNEATMKT---ENGSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHP 175
Cdd:PRK02645 125 LQARVfegdRSNEEPVSESYYALNDFYLKPaseDRSPTCILELEIDGEVVDQYQGDGLIVSTPTGSTAYTMAAGGPILHP 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 518673963 176 SLEAIQIAEIA--SINNRvfrtvgsPLVLPKHHTCLITPVNHNTIRT 220
Cdd:PRK02645 205 GIDAIIVTPICpmSLSSR-------PIVIPPGSRVVIWPLGDYDLNI 244
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
15-185 1.74e-22

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 96.34  E-value: 1.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  15 TLKHKMMNQMNSF-HMMEDTENPEIVISVGGDGTLLQAfhqySHMLSN--VAFVGVHTGHLGFYADWLPHEVEKLIDEIH 91
Cdd:PRK14076 327 FLYNKLKNRLNEEcNLIDDIEEISHIISIGGDGTVLRA----SKLVNGeeIPIICINMGTVGFLTEFSKEEIFKAIDSII 402

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  92 HSEFQVIEYP-LLEIIVKYNNTKneTRYLALNEATMKTENGSTLVA-DVAIRGKHFERFRGDGLCISTPSGSTAYNKALG 169
Cdd:PRK14076 403 SGEYEIEKRTkLSGFILKDGHQN--ILPSALNEVVITTKNPAKMLHfEVYVNGELVEEVRADGIIISTPTGSTAYSLSAG 480

                        170
                 ....*....|....*.
gi 518673963 170 GALIHPSLEAIQIAEI 185
Cdd:PRK14076 481 GPIVEPTVDGFIIVPI 496
ppnK PRK01231
NAD(+) kinase;
37-180 3.83e-22

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 92.71  E-value: 3.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  37 EIVISVGGDGTLLQAfhqySHML--SNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIEYPLLEIIVKynnTKN 114
Cdd:PRK01231  64 DLVIVVGGDGSLLGA----ARALarHNVPVLGINRGRLGFLTDIRPDELEFKLAEVLDGHYQEEERFLLEAEVR---RGG 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518673963 115 ETRY--LALNEATMKTENGSTLVA-DVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAI 180
Cdd:PRK01231 137 EVIGqgDALNDVVLHPGKSTRMIEfELYIDGQFVCSQRSDGLIVSTPTGSTAYALSGGGPIMHPKLDAI 205
pnk PRK14075
NAD(+) kinase;
1-186 5.16e-22

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 91.72  E-value: 5.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963   1 MRYTILSKGD--SKSNTLKHKMMNQMNSFHMMEDTENP----EIVISVGGDGTLLQAFHqyshmLSNVAFVGVHTGHLGF 74
Cdd:PRK14075   1 MKLGIFYREEkeKEAKFLKEKISKEHEVVEFCEASASGkvtaDLIIVVGGDGTVLKAAK-----KVGTPLVGFKAGRLGF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  75 YADWLPHEVEKLIDEIHHSEFQVIEYPLLEIIVKYNNtknetrYLALNEATM-KTENGSTLVADVAIRGKHFERFRGDGL 153
Cdd:PRK14075  76 LSSYTLEEIDRFLEDLKNWNFREEKRWFLKIESELGN------HLALNDVTLeRDPSQKMVEIEVSFEDHSSMWFFADGV 149

                        170       180       190
                 ....*....|....*....|....*....|...
gi 518673963 154 CISTPSGSTAYNKALGGALIHPSLEAIQIAEIA 186
Cdd:PRK14075 150 VISTPTGSTAYSLSLGGPIILPNCEVFEITPIA 182
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 22-191 6.34e-20

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 86.83  E-value: 6.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  22 NQMNSFHMMEDTENPEI---VISVGGDGTLLQAFHQYSHMlsNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVI 98
Cdd:PRK04539  52 QDTVGCHIVNKTELGQYcdlVAVLGGDGTFLSVAREIAPR--AVPIIGINQGHLGFLTQIPREYMTDKLLPVLEGKYLAE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  99 EYPLLEIIVkYNNTKNETRYLALNEATM-KTENGSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSL 177
Cdd:PRK04539 130 ERILIEAAL-IREGKTAERALALNDAVLsRGGAGQMIEFEVFVNREFVYTQRSDGLIVSTPTGSTAYSLAAGGPIMQAGL 208

                        170
                 ....*....|....*.
gi 518673963 178 EAIQIAEIA--SINNR 191
Cdd:PRK04539 209 HAFTLVPICpqSMTNR 224
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 31-186 1.55e-19

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 85.74  E-value: 1.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  31 EDTENPEIVISVGGDGTLLQAfHQYSHMlSNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIEYPLLEIIVKYN 110
Cdd:PRK03372  68 DAADGCELVLVLGGDGTILRA-AELARA-ADVPVLGVNLGHVGFLAEAEAEDLDEAVERVVDRDYRVEERMTLDVTVRVG 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518673963 111 NTKNETRYlALNEATmkTENGSTL-VADVAIR--GKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIA 186
Cdd:PRK03372 146 GEIVWRGW-ALNEAS--LEKADREgMLEVVLEvdGRPVSSFGCDGVLVSTPTGSTAYAFSAGGPVVWPDLEALLVVPLN 221
ppnK PRK03708
NAD(+) kinase;
35-249 5.24e-19

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 83.99  E-value: 5.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  35 NPEIVISVGGDGTLLQAFHQYShmlSNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIEYPLLEIIVKYNNTKN 114
Cdd:PRK03708  57 DVDFIIAIGGDGTILRIEHKTK---KDIPILGINMGTLGFLTEVEPEETFFALSRLLEGDYFIDERIKLRVYINGENVPD 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 115 etrylALNE-ATMKTENGSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIASinnrvF 193
Cdd:PRK03708 134 -----ALNEvVILTGIPGKIIHLKYYVDGELADEVRADGLIISTPTGSTAYAMSAGGPFVDPRLDAILIAPLCP-----F 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 518673963 194 RTVGSPLVLPKHHTCLITPV-NHNTIRTTIDHVSLKHKN-VSDIQFRVANEKVRFARF 249
Cdd:PRK03708 204 KLSSRPMVVPSSSRIDVKLLrTGREIILVIDGQYYEELPpDTEITIKKSPRKTKFVRF 261
ppnK PRK02155
NAD kinase;
40-203 4.26e-18

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 81.53  E-value: 4.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  40 ISVGGDGTLL---QAFHQYshmlsNVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIEYPLLEIIVKYNNtknET 116
Cdd:PRK02155  68 VVLGGDGTMLgigRQLAPY-----GVPLIGINHGRLGFITDIPLDDMQETLPPMLAGNYEEEERMLLEARVVRDG---EP 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 117 RY--LALNEATMKTENGSTLVA-DVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIA--SINNR 191
Cdd:PRK02155 140 IFhaLAFNDVVVNRSGFSGMVElRVSVDGRFMYNQRSDGLIVATPTGSTAYALSAGGPILHPQLPGWVLVPIAphTLSNR 219

                        170
                 ....*....|..
gi 518673963 192 vfrtvgsPLVLP 203
Cdd:PRK02155 220 -------PIVLP 224
ppnK PRK03378
inorganic polyphosphate/ATP-NAD kinase; Provisional
 22-180 9.65e-17

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235122 [Multi-domain]  Cd Length: 292  Bit Score: 78.06  E-value: 9.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  22 NQMNSFHMMEDTENPEIVISVGGDGTLLQAfhqySHMLS--NVAFVGVHTGHLGFYADWLPHEVEKLIDEIHHSEFQVIE 99
Cdd:PRK03378  50 KNVKTGTLAEIGQQADLAIVVGGDGNMLGA----ARVLAryDIKVIGINRGNLGFLTDLDPDNALQQLSDVLEGHYISEK 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 100 YPLLEIIV-KYNNTKneTRYLALNEATMKTENgstlVAD-----VAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALI 173
Cdd:PRK03378 126 RFLLEAQVcRHGQQK--RISTAINEVVLHPGK----VAHmiefeVYIDDNFAFSQRSDGLIISTPTGSTAYSLSAGGPIL 199


                 ....*..
gi 518673963 174 HPSLEAI 180
Cdd:PRK03378 200 TPSLDAI 206
ppnK PRK04761
inorganic polyphosphate/ATP-NAD kinase; Reviewed
 34-170 1.94e-15

inorganic polyphosphate/ATP-NAD kinase; Reviewed


Pssm-ID: 179876 [Multi-domain]  Cd Length: 246  Bit Score: 73.70  E-value: 1.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  34 ENPEIVISVGGDGTLLQAFHQYshMLSNVAFVGVHTGHLGF----YADwlphevEKLIDEIHHSEFQVIeYPLLEIIVky 109
Cdd:PRK04761  24 EEADVIVALGGDGFMLQTLHRY--MNSGKPVYGMNRGSVGFlmneYSE------DDLLERIAAAEPTVL-HPLRMTAT-- 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518673963 110 NNTKNETRYLALNEATM--KTENGSTLvaDVAIRGK-HFERFRGDGLCISTPSGSTAYNKALGG 170
Cdd:PRK04761  93 DVSGEVHEALAINEVSLfrQTRQAAKL--RISIDGKvRMEELVCDGVLVATPAGSTAYNLSAHG 154
ppnK PRK02231
NAD(+) kinase;
37-180 8.84e-15

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 72.14  E-value: 8.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  37 EIVISVGGDGTLLQAFHQYSHMlsNVAFVGVHTGHLGFYADWLPHEV-EKLIDEIHHSEFQVIEYPLLEIIVKyNNTKNE 115
Cdd:PRK02231  44 QLAIVIGGDGNMLGRARVLAKY--DIPLIGINRGNLGFLTDIDPKNAyEQLEACLERGEFFVEERFLLEAKIE-RNGKII 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518673963 116 TRYLALNEATMK-TENGSTLVADVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAI 180
Cdd:PRK02231 121 ATSNALNEVVIHpAKIAHMIDFHVYIDDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPNLNAI 186
ppnK PRK02649
NAD(+) kinase;
40-256 1.38e-14

NAD(+) kinase;


Pssm-ID: 179456 [Multi-domain]  Cd Length: 305  Bit Score: 71.93  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  40 ISVGGDGTLLQAFHQYSHmlSNVAFVGVHTGHLGFYAD-WLPHeVEKLIDEIHHSEFQVIEYPLLEIIVkynnTKNETRY 118
Cdd:PRK02649  73 IVLGGDGTVLSAARQLAP--CGIPLLTINTGHLGFLTEaYLNQ-LDEAIDQVLAGQYTIEERTMLTVSV----MRGDQLR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 119 ---LALNEATMKTENGSTLVadvairgkHFERFRG---------DGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIA 186
Cdd:PRK02649 146 weaLSLNEMVLHREPLTSMC--------HFEIAIGrhapvdiaaDGVILSTPTGSTAYSLSAGGPVITPDVPVLQLTPIC 217

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518673963 187 --SINNRVfrtvgspLVLPKHHTCLITPVNHNTIRTTIDHVSLKHKNVSD-IQFRVANEKVRFARFRPFPFWK 256
Cdd:PRK02649 218 phSLASRA-------LVFSDSEPVTVFPATPERLVMVVDGNAGCYVWPEDrVLIRRSPYPVRFIRLQDPEFFR 283
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 37-207 3.24e-13

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 69.09  E-value: 3.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  37 EIVISVGGDGTLLQAFHQYSHMLSNVafVGVHTGHLGFYADWLPHEVEKLIDEI----------HHSEFQVIEYPlleii 106
Cdd:PLN02935 264 DLVITLGGDGTVLWAASMFKGPVPPV--VPFSMGSLGFMTPFHSEQYRDCLDAIlkgpisitlrHRLQCHIIRDA----- 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 107 vKYNNTKNETRYLALNEATMKTENGSTLVADVAIRGKHF-ERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEI 185
Cdd:PLN02935 337 -AKNEYETEEPILVLNEVTIDRGISSFLTNLECYCDNSFvTCVQGDGLILSTTSGSTAYSLAAGGSMVHPQVPGILFTPI 415

                        170       180
                 ....*....|....*....|..
gi 518673963 186 ASiNNRVFRtvgsPLVLPKHHT 207
Cdd:PLN02935 416 CP-HSLSFR----PLILPEYVT 432
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-248 3.43e-11

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 59.24  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  121 LNEATMKTENGSTLVA-DVAIRGKHFERFRGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIASINNRvFRtvgsP 199
Cdd:pfam20143   1 LNEVVYVRGPGATMIEfELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLS-SR----P 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 518673963  200 LVLPKHHTCLITPVN-HNTIRTTIDHVSLKHKNVSDIQFRVANEKVRFAR 248
Cdd:pfam20143  76 IVVSSSSKLRIRVLSrAEALLVDDGDPELDISPGDRVRVRKSYYKAKFIR 125
PLN02727 PLN02727
NAD kinase
 149-203 2.33e-05

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 45.26  E-value: 2.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518673963 149 RGDGLCISTPSGSTAYNKALGGALIHPSLEAIQIAEIASiNNRVFRtvgsPLVLP 203
Cdd:PLN02727 862 QGDGVIVATPTGSTAYSTAAGGSMVHPNVPCMLFTPICP-HSLSFR----PVILP 911
PLN02929 PLN02929
NADH kinase
 35-181 5.08e-04

NADH kinase


Pssm-ID: 215502 [Multi-domain]  Cd Length: 301  Bit Score: 40.79  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963  35 NPEIVISVGGDGTLLQAFHqysHMLSNVAFVGVHTGHLGfyadwlPHEVEKLIDEIHHS------------EF-QVIE-- 99
Cdd:PLN02929  64 DVDLVVAVGGDGTLLQASH---FLDDSIPVLGVNSDPTQ------KDEVEEYSDEFDARrstghlcaataeDFeQVLDdv 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518673963 100 -----YP--LLEIIVKYNNTKNETRylALNEATMKTENGSTL----VADVAIRGKHFERF--RGDGLCISTPSGSTAYNK 166
Cdd:PLN02929 135 lfgrlKPteLSRISTVVNGTLLETP--ALNDVLIAHPSPAAVsrfsFRVGRQGGSSGPLInvRSSGLRVSTAAGSTAAML 212

                        170
                 ....*....|....*
gi 518673963 167 ALGGALIHPSLEAIQ 181
Cdd:PLN02929 213 SAGGFPMPLLSRDLQ 227
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 37-92 2.16e-03

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 37.34  E-value: 2.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 518673963   37 EIVISVGGDGTLLQAfhqySHMLSNVA--FVGVHTGHLGFYADWLPHEVEKLIDEIHH 92
Cdd:pfam01513  75 DLIIVLGGDGTALRA----ARLLQKAVipILGVNTGVLGFLTEFEPEAAFELLERLLE 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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