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Conserved domains on  [gi|518674679|ref|WP_019836372|]
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MULTISPECIES: type II toxin-antitoxin system HigB family toxin [Acinetobacter]

Protein Classification

type II toxin-antitoxin system HigB family toxin( domain architecture ID 10008707)

type II toxin-antitoxin (TA) system HigB family toxin similar to Escherichia coli mRNA interferase HigB, the toxin component of the HigB-HigA TA system; induced by amino acid starvation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 2-89 7.61e-36

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


:

Pssm-ID: 443716  Cd Length: 89  Bit Score: 116.78  E-value: 7.61e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518674679  2 HVITHARIIEAMHKWPQAETALDGWYRIIKANDPKDFAEMKQLFPAVDKVG-KFHVFDIGGNKIRLIAVVMYQAKRVYIR 80
Cdd:COG4680   1 RIISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVGnNRVVFNIKGNKYRLIVAINYERQIVYIK 80


                ....*....
gi 518674679 81 HVLSHKEYD 89
Cdd:COG4680  81 FIGTHAEYD 89
 
Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 2-89 7.61e-36

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443716  Cd Length: 89  Bit Score: 116.78  E-value: 7.61e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518674679  2 HVITHARIIEAMHKWPQAETALDGWYRIIKANDPKDFAEMKQLFPAVDKVG-KFHVFDIGGNKIRLIAVVMYQAKRVYIR 80
Cdd:COG4680   1 RIISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVGnNRVVFNIKGNKYRLIVAINYERQIVYIK 80


                ....*....
gi 518674679 81 HVLSHKEYD 89
Cdd:COG4680  81 FIGTHAEYD 89
HigB_toxin pfam09907
HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of ...
 19-90 1.94e-31

HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.


Pssm-ID: 462925  Cd Length: 73  Bit Score: 105.24  E-value: 1.94e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518674679  19 AETALDGWYRIIKANDPKDFAEMKQLFPAVDKVG-KFHVFDIGGNKIRLIAVVMYQAKRVYIRHVLSHKEYDK 90
Cdd:pfam09907  1 AEQALEAWYREVKKAEWKSPADVKAVFPSADIVGnNRVVFNIGGNKYRLIVAIDYERQKVYIKFIGTHAEYDK 73
 
Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 2-89 7.61e-36

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443716  Cd Length: 89  Bit Score: 116.78  E-value: 7.61e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518674679  2 HVITHARIIEAMHKWPQAETALDGWYRIIKANDPKDFAEMKQLFPAVDKVG-KFHVFDIGGNKIRLIAVVMYQAKRVYIR 80
Cdd:COG4680   1 RIISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVGnNRVVFNIKGNKYRLIVAINYERQIVYIK 80


                ....*....
gi 518674679 81 HVLSHKEYD 89
Cdd:COG4680  81 FIGTHAEYD 89
HigB_toxin pfam09907
HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of ...
 19-90 1.94e-31

HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.


Pssm-ID: 462925  Cd Length: 73  Bit Score: 105.24  E-value: 1.94e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518674679  19 AETALDGWYRIIKANDPKDFAEMKQLFPAVDKVG-KFHVFDIGGNKIRLIAVVMYQAKRVYIRHVLSHKEYDK 90
Cdd:pfam09907  1 AEQALEAWYREVKKAEWKSPADVKAVFPSADIVGnNRVVFNIGGNKYRLIVAIDYERQKVYIKFIGTHAEYDK 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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