MULTISPECIES: hypothetical protein [Gammaproteobacteria]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| PLPDE_III super family | cl00261 | Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; The fold type III PLP-dependent enzyme ... |
1-64 | 4.33e-23 | ||
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; The fold type III PLP-dependent enzyme family is predominantly composed of two-domain proteins with similarity to bacterial alanine racemases (AR) including eukaryotic ornithine decarboxylases (ODC), prokaryotic diaminopimelate decarboxylases (DapDC), biosynthetic arginine decarboxylases (ADC), carboxynorspermidine decarboxylases (CANSDC), and similar proteins. AR-like proteins contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. These proteins play important roles in the biosynthesis of amino acids and polyamine. The family also includes the single-domain YBL036c-like proteins, which contain a single PLP-binding TIM-barrel domain without any N- or C-terminal extensions. Due to the lack of a second domain, these proteins may possess only limited D- to L-alanine racemase activity or non-specific racemase activity. The actual alignment was detected with superfamily member cd06826: Pssm-ID: 469695 [Multi-domain] Cd Length: 365 Bit Score: 88.94 E-value: 4.33e-23
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| Name | Accession | Description | Interval | E-value | ||
| PLPDE_III_AR2 | cd06826 | Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; This subfamily is ... |
1-64 | 4.33e-23 | ||
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; This subfamily is composed of bacterial alanine racemases (EC 5.1.1.1) with similarity to Yersinia pestis and Vibrio cholerae alanine racemase (AR) 2. ARs catalyze the interconversion between L- and D-alanine, an essential component of the peptidoglycan layer of bacterial cell walls. These proteins are similar to other bacterial ARs and are fold type III PLP-dependent enzymes containing contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity. Pssm-ID: 143499 [Multi-domain] Cd Length: 365 Bit Score: 88.94 E-value: 4.33e-23
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| PRK13340 | PRK13340 | alanine racemase; Reviewed |
1-64 | 1.51e-21 | ||
alanine racemase; Reviewed Pssm-ID: 183984 [Multi-domain] Cd Length: 406 Bit Score: 85.06 E-value: 1.51e-21
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| Alr | COG0787 | Alanine racemase [Cell wall/membrane/envelope biogenesis]; Alanine racemase is part of the ... |
2-51 | 6.85e-07 | ||
Alanine racemase [Cell wall/membrane/envelope biogenesis]; Alanine racemase is part of the Pathway/BioSystem: Mureine biosynthesis Pssm-ID: 440550 [Multi-domain] Cd Length: 368 Bit Score: 43.94 E-value: 6.85e-07
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| Ala_racemase_N | pfam01168 | Alanine racemase, N-terminal domain; |
1-50 | 5.32e-05 | ||
Alanine racemase, N-terminal domain; Pssm-ID: 460095 [Multi-domain] Cd Length: 220 Bit Score: 38.36 E-value: 5.32e-05
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| Name | Accession | Description | Interval | E-value | ||
| PLPDE_III_AR2 | cd06826 | Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; This subfamily is ... |
1-64 | 4.33e-23 | ||
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; This subfamily is composed of bacterial alanine racemases (EC 5.1.1.1) with similarity to Yersinia pestis and Vibrio cholerae alanine racemase (AR) 2. ARs catalyze the interconversion between L- and D-alanine, an essential component of the peptidoglycan layer of bacterial cell walls. These proteins are similar to other bacterial ARs and are fold type III PLP-dependent enzymes containing contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity. Pssm-ID: 143499 [Multi-domain] Cd Length: 365 Bit Score: 88.94 E-value: 4.33e-23
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| PRK13340 | PRK13340 | alanine racemase; Reviewed |
1-64 | 1.51e-21 | ||
alanine racemase; Reviewed Pssm-ID: 183984 [Multi-domain] Cd Length: 406 Bit Score: 85.06 E-value: 1.51e-21
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| Alr | COG0787 | Alanine racemase [Cell wall/membrane/envelope biogenesis]; Alanine racemase is part of the ... |
2-51 | 6.85e-07 | ||
Alanine racemase [Cell wall/membrane/envelope biogenesis]; Alanine racemase is part of the Pathway/BioSystem: Mureine biosynthesis Pssm-ID: 440550 [Multi-domain] Cd Length: 368 Bit Score: 43.94 E-value: 6.85e-07
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| PLPDE_III_AR | cd00430 | Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; This family includes ... |
1-49 | 1.77e-05 | ||
Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family. Pssm-ID: 143481 [Multi-domain] Cd Length: 367 Bit Score: 39.79 E-value: 1.77e-05
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| Ala_racemase_N | pfam01168 | Alanine racemase, N-terminal domain; |
1-50 | 5.32e-05 | ||
Alanine racemase, N-terminal domain; Pssm-ID: 460095 [Multi-domain] Cd Length: 220 Bit Score: 38.36 E-value: 5.32e-05
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