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Conserved domains on  [gi|518699204|ref|WP_019860648|]
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MULTISPECIES: Xaa-Pro peptidase family protein [Mesorhizobium]

Protein Classification

M24 family metallopeptidase( domain architecture ID 11414248)

M24 family metallopeptidase cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.90.230.10
EC:  3.4.-.-
Gene Ontology:  GO:0008233|GO:0016787|GO:0004177|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24|M24B
PubMed:  7674922|16229471|30536999
SCOP:  3000126

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
15-382 1.25e-55

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


:

Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 184.64  E-value: 1.25e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  15 DRLMIEMAEKKLDAILLFAQESMYWLTGYDTFgFCFFQCLVVKADGSMVLLTRSADLRQarhtsiidnivlwtdrnganp 94
Cdd:COG0006    1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS-PERLAALLVTADGEPVLFVDELEAER--------------------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  95 avdlrnllndldllgarigveydthgltayngrrldeqlqtfgQIADASGIVGRLRLFKSPAEIAKAEKAANLSDDALDA 174
Cdd:COG0006   59 -------------------------------------------ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEA 95

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 175 ALPLIKQGGDEALILAAMQGAIFAGGGDYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVFHHYHAPMMRTVL 254
Cdd:COG0006   96 ALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVA 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 255 TGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRLNACGYSVGARFTpswmDMPMFYQGNPE 334
Cdd:COG0006  176 VGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVH----EGPQISPGNDR 251

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 518699204 335 PIAPHMTLFAHMIIMDsETETAMTLGRTYLTTESQPKPLSRHDLDLIV 382
Cdd:COG0006  252 PLEPGMVFTIEPGIYI-PGIGGVRIEDTVLVTEDGAEVLTRLPRELLE 298
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
15-382 1.25e-55

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 184.64  E-value: 1.25e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  15 DRLMIEMAEKKLDAILLFAQESMYWLTGYDTFgFCFFQCLVVKADGSMVLLTRSADLRQarhtsiidnivlwtdrnganp 94
Cdd:COG0006    1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS-PERLAALLVTADGEPVLFVDELEAER--------------------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  95 avdlrnllndldllgarigveydthgltayngrrldeqlqtfgQIADASGIVGRLRLFKSPAEIAKAEKAANLSDDALDA 174
Cdd:COG0006   59 -------------------------------------------ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEA 95

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 175 ALPLIKQGGDEALILAAMQGAIFAGGGDYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVFHHYHAPMMRTVL 254
Cdd:COG0006   96 ALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVA 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 255 TGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRLNACGYSVGARFTpswmDMPMFYQGNPE 334
Cdd:COG0006  176 VGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVH----EGPQISPGNDR 251

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 518699204 335 PIAPHMTLFAHMIIMDsETETAMTLGRTYLTTESQPKPLSRHDLDLIV 382
Cdd:COG0006  252 PLEPGMVFTIEPGIYI-PGIGGVRIEDTVLVTEDGAEVLTRLPRELLE 298
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 166-370 4.51e-41

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 143.75  E-value: 4.51e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 166 NLSDDALDAALPLIKQGGDEALILAAMQGAIFAGGGdYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVFHHY 245
Cdd:cd01066    9 EIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVDLGGVYDGY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 246 HAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRLNACGYSVGARFTPSWMDM 325
Cdd:cd01066   88 HADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFGHRTGHGIGLEIHEPPVLK 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 518699204 326 PmfyqGNPEPIAPHMTLFAHMIIMDSETETAMtLGRTYLTTESQP 370
Cdd:cd01066  168 A----GDDTVLEPGMVFAVEPGLYLPGGGGVR-IEDTVLVTEDGP 207
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 167-342 9.20e-29

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 111.18  E-value: 9.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  167 LSDDALDAALPLIKQGGDEALILAAMQGAIFA-GGGDYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVF-HH 244
Cdd:pfam00557   9 IAAAALEAALAAIRPGVTERELAAELEAARLRrGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLIDVGAEYdGG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  245 YHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRLNACGYSVGARFTpswmD 324
Cdd:pfam00557  89 YCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGLEVH----E 164

                         170
                  ....*....|....*....
gi 518699204  325 MPMF-YQGNPEPIAPHMTL 342
Cdd:pfam00557 165 GPYIsRGGDDRVLEPGMVF 183
PRK15173 PRK15173
peptidase; Provisional
 126-315 2.48e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 45.86  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 126 GRRLDEQLQTFGQIADASGIVGRLRLFKSPAEIAKAEKAANLSDDALDAALPLIKQGGDEALILAAMQGAIFAGGGDYPA 205
Cdd:PRK15173  69 GKRVIDAVMPNVDFVDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 206 NEFIIGSGVDaLLCRYKAGRRKLTKNDQLTLEWAGVFHHYHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNT 285
Cdd:PRK15173 149 RFHLISVGAD-FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVK 227

                        170       180       190
                 ....*....|....*....|....*....|
gi 518699204 286 FGDVFDAHARTMEAHGLTKHRLNACGYSVG 315
Cdd:PRK15173 228 MKDVFDSTMEVIKKSGLPNYNRGHLGHGNG 257
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
15-382 1.25e-55

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 184.64  E-value: 1.25e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  15 DRLMIEMAEKKLDAILLFAQESMYWLTGYDTFgFCFFQCLVVKADGSMVLLTRSADLRQarhtsiidnivlwtdrnganp 94
Cdd:COG0006    1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS-PERLAALLVTADGEPVLFVDELEAER--------------------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  95 avdlrnllndldllgarigveydthgltayngrrldeqlqtfgQIADASGIVGRLRLFKSPAEIAKAEKAANLSDDALDA 174
Cdd:COG0006   59 -------------------------------------------ELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEA 95

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 175 ALPLIKQGGDEALILAAMQGAIFAGGGDYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVFHHYHAPMMRTVL 254
Cdd:COG0006   96 ALAALRPGVTEREVAAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVA 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 255 TGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRLNACGYSVGARFTpswmDMPMFYQGNPE 334
Cdd:COG0006  176 VGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVH----EGPQISPGNDR 251

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 518699204 335 PIAPHMTLFAHMIIMDsETETAMTLGRTYLTTESQPKPLSRHDLDLIV 382
Cdd:COG0006  252 PLEPGMVFTIEPGIYI-PGIGGVRIEDTVLVTEDGAEVLTRLPRELLE 298
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 166-370 4.51e-41

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 143.75  E-value: 4.51e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 166 NLSDDALDAALPLIKQGGDEALILAAMQGAIFAGGGdYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVFHHY 245
Cdd:cd01066    9 EIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLVDLGGVYDGY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 246 HAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRLNACGYSVGARFTPSWMDM 325
Cdd:cd01066   88 HADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFGHRTGHGIGLEIHEPPVLK 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 518699204 326 PmfyqGNPEPIAPHMTLFAHMIIMDSETETAMtLGRTYLTTESQP 370
Cdd:cd01066  168 A----GDDTVLEPGMVFAVEPGLYLPGGGGVR-IEDTVLVTEDGP 207
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 167-342 9.20e-29

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 111.18  E-value: 9.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  167 LSDDALDAALPLIKQGGDEALILAAMQGAIFA-GGGDYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVF-HH 244
Cdd:pfam00557   9 IAAAALEAALAAIRPGVTERELAAELEAARLRrGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLIDVGAEYdGG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204  245 YHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRLNACGYSVGARFTpswmD 324
Cdd:pfam00557  89 YCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGLEVH----E 164

                         170
                  ....*....|....*....
gi 518699204  325 MPMF-YQGNPEPIAPHMTL 342
Cdd:pfam00557 165 GPYIsRGGDDRVLEPGMVF 183
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 13-151 2.67e-18

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 80.04  E-value: 2.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204   13 RRDRLMIEMAEKKLDAILLFAQESMYWLTGydtFGFCFFQCLVVKADGSmVLLTRSADL-RQARHTSIIDNIVLWTDRNG 91
Cdd:pfam01321   1 RLEKLRKLMEEKGLDAALVTSPENLRYLTG---FTGSRGLLLLVTADGA-LLLVDALEYeRAAAESAPDFDVVPYRDYEA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204   92 ANPAVdlrnllNDLDLLGARIGVEYDTHGLTAYngRRLDEQLQtFGQIADASGIVGRLRL 151
Cdd:pfam01321  77 LADLL------KELGAGGKRVGFEADALTVAFY--EALKEALP-GAELVDVSGLIERLRM 127
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 167-315 1.16e-16

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 77.93  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 167 LSDDALDAALPLIKQGGDEALILAAMQGAIFAGGGDYPANEFIIGSGVDALLCRYKAGRRKLTKNDQLTLEWAGVFHHYH 246
Cdd:cd01092   10 IADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLIDFGAIYDGYC 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518699204 247 APMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVfDAHAR-TMEAHGLTK---HRLnacGYSVG 315
Cdd:cd01092   90 SDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEV-DKAARdVIEEAGYGEyfiHRT---GHGVG 158
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 224-318 1.14e-06

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 49.03  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 224 GRRKLTKNDQLTLEWAGVFHHYHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLT 303
Cdd:cd01086   72 DDRVLKDGDIVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYS 151

                         90
                 ....*....|....*
gi 518699204 304 KHRlNACGYSVGARF 318
Cdd:cd01086  152 VVR-EFGGHGIGRKF 165
PRK15173 PRK15173
peptidase; Provisional
 126-315 2.48e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 45.86  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 126 GRRLDEQLQTFGQIADASGIVGRLRLFKSPAEIAKAEKAANLSDDALDAALPLIKQGGDEALILAAMQGAIFAGGGDYPA 205
Cdd:PRK15173  69 GKRVIDAVMPNVDFVDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 206 NEFIIGSGVDaLLCRYKAGRRKLTKNDQLTLEWAGVFHHYHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNT 285
Cdd:PRK15173 149 RFHLISVGAD-FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVK 227

                        170       180       190
                 ....*....|....*....|....*....|
gi 518699204 286 FGDVFDAHARTMEAHGLTKHRLNACGYSVG 315
Cdd:PRK15173 228 MKDVFDSTMEVIKKSGLPNYNRGHLGHGNG 257
PRK14575 PRK14575
putative peptidase; Provisional
 126-315 3.46e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 45.47  E-value: 3.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 126 GRRLDEQLQTFGQIADASGIVGRLRLFKSPAEIAKAEKAANLSDDALDAALPLIKQGGDEALILAAMQGAIFAGGGDYPA 205
Cdd:PRK14575 152 GKRVIDAVMPNVDFVDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFS 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 206 NEFIIGSGVDaLLCRYKAGRRKLTKNDQLTLEWAGVFHHYHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNT 285
Cdd:PRK14575 232 RFHLISVGAD-FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVK 310

                        170       180       190
                 ....*....|....*....|....*....|
gi 518699204 286 FGDVFDAHARTMEAHGLTKHRLNACGYSVG 315
Cdd:PRK14575 311 MKDVFDSTMEVIKKSGLPNYNRGHLGHGNG 340
PRK05716 PRK05716
methionine aminopeptidase; Validated
 245-318 1.38e-04

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 43.20  E-value: 1.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518699204 245 YHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVFDAHARTMEAHGLTKHRlNACGYSVGARF 318
Cdd:PRK05716 103 YHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFSVVR-EYCGHGIGRKF 175
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
224-314 5.39e-04

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 41.14  E-value: 5.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 224 GRRKLTKNDQLTLEWAGVFHHYHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVfdAHArtMEAHgLT 303
Cdd:COG0024   80 SDRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDI--GHA--IQSY-AE 154

                         90
                 ....*....|.
gi 518699204 304 KHrlnacGYSV 314
Cdd:COG0024  155 SN-----GYSV 160
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 242-319 4.07e-03

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 38.66  E-value: 4.07e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518699204 242 FHHYHAPMMRTVLTGKVSKRHQELFDAARAALLAVEKAMTPGNTFGDVfdahARTMEAHgltkhrLNACGYSVGARFT 319
Cdd:PRK12896 105 LDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDI----GRAIEDF------AKKNGYSVVRDLT 172
PRK09795 PRK09795
aminopeptidase; Provisional
 149-321 5.65e-03

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 38.38  E-value: 5.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 149 LRLFKSPAEIAKAEKAANLSDDALDAALPLIKQGGDEALILAAMQGAIFAGGGDYPANEFIIGSGVDALLCRYKAGRRKL 228
Cdd:PRK09795 124 LRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIV 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518699204 229 TKNDQLTLEWAGVFHHYHAPMMRTVLTG--KVSKRHQELFDAARAAL---LAVEKAMTPGNTFGDVFDAHARTMEAHGLT 303
Cdd:PRK09795 204 AAGEFVTLDFGALYQGYCSDMTRTLLVNgeGVSAESHPLFNVYQIVLqaqLAAISAIRPGVRCQQVDDAARRVITEAGYG 283

                        170       180
                 ....*....|....*....|....
gi 518699204 304 KHRLNACGYSVG------ARFTPS 321
Cdd:PRK09795 284 DYFGHNTGHAIGievhedPRFSPR 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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