|
Name |
Accession |
Description |
Interval |
E-value |
| PncA |
COG1335 |
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ... |
3-177 |
9.79e-54 |
|
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440946 [Multi-domain] Cd Length: 169 Bit Score: 168.16 E-value: 9.79e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVD-GSLPVgQPGIDIAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESSLFPPHNLRGTRGRELYGS 81
Cdd:COG1335 1 ALLVIDVQNDFVPpGALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVPE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 82 LntvyeQNRESIYWMDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGH 161
Cdd:COG1335 80 L-----APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAH 154
|
170
....*....|....*.
gi 518752642 162 SWALGHFRGsLGAGVV 177
Cdd:COG1335 155 EAALARLRA-AGATVV 169
|
|
| cysteine_hydrolases |
cd00431 |
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ... |
3-169 |
7.06e-49 |
|
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.
Pssm-ID: 238245 [Multi-domain] Cd Length: 161 Bit Score: 155.50 E-value: 7.06e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVDGSLPVGQPGIDIAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESsLFPPHNLRGTRGRELYGSL 82
Cdd:cd00431 1 ALLVVDMQNDFVPGGGLLLPGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 83 ntvyeQNRESIYWMDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHS 162
Cdd:cd00431 80 -----APLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEEDHE 154
|
....*..
gi 518752642 163 WALGHFR 169
Cdd:cd00431 155 AALERLA 161
|
|
| Isochorismatase |
pfam00857 |
Isochorismatase family; This family are hydrolase enzymes. |
3-180 |
3.26e-46 |
|
Isochorismatase family; This family are hydrolase enzymes.
Pssm-ID: 376404 [Multi-domain] Cd Length: 173 Bit Score: 149.48 E-value: 3.26e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVDGSLPVGQPGIDIAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESSLFPPHNLRGTRGRELYGSL 82
Cdd:pfam00857 2 ALLVIDMQNDFVDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVPEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 83 nTVYEQNRESiywmDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHS 162
Cdd:pfam00857 82 -APLPGDLVV----DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHD 156
|
170
....*....|....*...
gi 518752642 163 WALGHFRGSlGAGVVSGE 180
Cdd:pfam00857 157 AALERLAQR-GAEVTTTE 173
|
|
| PTZ00331 |
PTZ00331 |
alpha/beta hydrolase; Provisional |
1-177 |
1.27e-22 |
|
alpha/beta hydrolase; Provisional
Pssm-ID: 240363 Cd Length: 212 Bit Score: 89.74 E-value: 1.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 1 MRALIVIDFTNDFV-DGSLPVgQPGIDIAPRVSELTE--AFvgsgDYVVMAVDLHETN-------------DPYHPESSL 64
Cdd:PTZ00331 12 NDALIIVDVQNDFCkGGSLAV-PDAEEVIPVINQVRQshHF----DLVVATQDWHPPNhisfasnhgkpkiLPDGTTQGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 65 FPPHNLRGTRGRELYGSL-----NTVYE--QNREsiywMDKtrYSAFSG-----TDLELKLRERGITELHLIGVCTDICV 132
Cdd:PTZ00331 87 WPPHCVQGTKGAQLHKDLvveriDIIIRkgTNRD----VDS--YSAFDNdkgskTGLAQILKAHGVRRVFICGLAFDFCV 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 518752642 133 LHTAVDAYNKGFSLTIHEDAVASFNPDGHSWALGHFrgsLGAGVV 177
Cdd:PTZ00331 161 LFTALDAVKLGFKVVVLEDATRAVDPDAISKQRAEL---LEAGVI 202
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PncA |
COG1335 |
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ... |
3-177 |
9.79e-54 |
|
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440946 [Multi-domain] Cd Length: 169 Bit Score: 168.16 E-value: 9.79e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVD-GSLPVgQPGIDIAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESSLFPPHNLRGTRGRELYGS 81
Cdd:COG1335 1 ALLVIDVQNDFVPpGALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVPE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 82 LntvyeQNRESIYWMDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGH 161
Cdd:COG1335 80 L-----APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDPEAH 154
|
170
....*....|....*.
gi 518752642 162 SWALGHFRGsLGAGVV 177
Cdd:COG1335 155 EAALARLRA-AGATVV 169
|
|
| cysteine_hydrolases |
cd00431 |
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ... |
3-169 |
7.06e-49 |
|
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.
Pssm-ID: 238245 [Multi-domain] Cd Length: 161 Bit Score: 155.50 E-value: 7.06e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVDGSLPVGQPGIDIAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESsLFPPHNLRGTRGRELYGSL 82
Cdd:cd00431 1 ALLVVDMQNDFVPGGGLLLPGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 83 ntvyeQNRESIYWMDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHS 162
Cdd:cd00431 80 -----APLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEEDHE 154
|
....*..
gi 518752642 163 WALGHFR 169
Cdd:cd00431 155 AALERLA 161
|
|
| Isochorismatase |
pfam00857 |
Isochorismatase family; This family are hydrolase enzymes. |
3-180 |
3.26e-46 |
|
Isochorismatase family; This family are hydrolase enzymes.
Pssm-ID: 376404 [Multi-domain] Cd Length: 173 Bit Score: 149.48 E-value: 3.26e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVDGSLPVGQPGIDIAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESSLFPPHNLRGTRGRELYGSL 82
Cdd:pfam00857 2 ALLVIDMQNDFVDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVPEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 83 nTVYEQNRESiywmDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHS 162
Cdd:pfam00857 82 -APLPGDLVV----DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHD 156
|
170
....*....|....*...
gi 518752642 163 WALGHFRGSlGAGVVSGE 180
Cdd:pfam00857 157 AALERLAQR-GAEVTTTE 173
|
|
| nicotinamidase |
cd01011 |
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ... |
1-177 |
7.69e-28 |
|
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).
Pssm-ID: 238493 Cd Length: 196 Bit Score: 103.11 E-value: 7.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 1 MRALIVIDFTNDFVD-GSLPVGQpGIDIAPRVSELTEAFvgSGDYVVMAVDLHETN---------------DPYHPESSL 64
Cdd:cd01011 1 TDALLVVDVQNDFCPgGALAVPG-GDAIVPLINALLSLF--QYDLVVATQDWHPANhasfasnhpgqmpfiTLPPGPQVL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 65 FPPHNLRGTRGRELYGSLNTV---------YEQNRESiywmdktrYSAF------SGTDLELKLRERGITELHLIGVCTD 129
Cdd:cd01011 78 WPDHCVQGTPGAELHPGLPVPdidlivrkgTNPDIDS--------YSAFfdndrrSSTGLAEYLRERGIDRVDVVGLATD 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 518752642 130 ICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHSWALGHFRgslGAGVV 177
Cdd:cd01011 150 YCVKATALDALKAGFEVRVLEDACRAVDPETIERAIEEMK---EAGVV 194
|
|
| PTZ00331 |
PTZ00331 |
alpha/beta hydrolase; Provisional |
1-177 |
1.27e-22 |
|
alpha/beta hydrolase; Provisional
Pssm-ID: 240363 Cd Length: 212 Bit Score: 89.74 E-value: 1.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 1 MRALIVIDFTNDFV-DGSLPVgQPGIDIAPRVSELTE--AFvgsgDYVVMAVDLHETN-------------DPYHPESSL 64
Cdd:PTZ00331 12 NDALIIVDVQNDFCkGGSLAV-PDAEEVIPVINQVRQshHF----DLVVATQDWHPPNhisfasnhgkpkiLPDGTTQGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 65 FPPHNLRGTRGRELYGSL-----NTVYE--QNREsiywMDKtrYSAFSG-----TDLELKLRERGITELHLIGVCTDICV 132
Cdd:PTZ00331 87 WPPHCVQGTKGAQLHKDLvveriDIIIRkgTNRD----VDS--YSAFDNdkgskTGLAQILKAHGVRRVFICGLAFDFCV 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 518752642 133 LHTAVDAYNKGFSLTIHEDAVASFNPDGHSWALGHFrgsLGAGVV 177
Cdd:PTZ00331 161 LFTALDAVKLGFKVVVLEDATRAVDPDAISKQRAEL---LEAGVI 202
|
|
| nicotinamidase_related |
cd01014 |
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ... |
3-165 |
1.42e-17 |
|
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.
Pssm-ID: 238496 [Multi-domain] Cd Length: 155 Bit Score: 75.32 E-value: 1.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVDGSLPvGQPGIDIAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESSLFPPHNLRGTRGRELYgsl 82
Cdd:cd01014 1 ALLVIDVQNGYFDGGLP-PLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGWEIHPELAPLEGETV--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 83 ntvyeqnresiywMDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHS 162
Cdd:cd01014 77 -------------IEKTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLPDHG 143
|
...
gi 518752642 163 WAL 165
Cdd:cd01014 144 GVL 146
|
|
| EntB1 |
COG1535 |
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism]; |
3-165 |
1.51e-17 |
|
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 441144 [Multi-domain] Cd Length: 204 Bit Score: 76.43 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVDGSLPVGQPGIDIAPRVSELTEAFVGSGD---YVVMAVDLHETNDPYHPEssLFPPHNLRGTRGRELY 79
Cdd:COG1535 21 ALLIHDMQNYFLRPYDPDEPPIRELVANIARLRDACRAAGIpvvYTAQPGDQTPEDRGLLND--FWGPGLTAGPEGQEIV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 80 GSLnTVYEQNRESIYWmdktRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPD 159
Cdd:COG1535 99 DEL-APAPGDTVLTKW----RYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPFVVADAVADFSRE 173
|
....*.
gi 518752642 160 GHSWAL 165
Cdd:COG1535 174 EHRMAL 179
|
|
| PRK11440 |
PRK11440 |
putative hydrolase; Provisional |
3-167 |
5.03e-16 |
|
putative hydrolase; Provisional
Pssm-ID: 183137 Cd Length: 188 Bit Score: 72.07 E-value: 5.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNdfvdGSLPV-GQP--GIDIAPRVSELTEAFVGSGDYVVM-----AVDLHETndPYHPESSLFPPHNLRGTR 74
Cdd:PRK11440 10 ALVVIDLQE----GILPFaGGPhtADEVVARAARLAAKFRASGSPVVLvrvgwSADYAEA--LKQPVDAPSPAKVLPENW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 75 GRelYGSLNTVYEQNRESIywmdKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVA 154
Cdd:PRK11440 84 WQ--HPAALGKTDSDIEVT----KRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACS 157
|
170
....*....|...
gi 518752642 155 SFNPDGHSWALGH 167
Cdd:PRK11440 158 AASAEQHQNSMNH 170
|
|
| CSHase |
cd01015 |
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ... |
3-178 |
1.36e-14 |
|
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.
Pssm-ID: 238497 [Multi-domain] Cd Length: 179 Bit Score: 67.81 E-value: 1.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDFVDGSLPVGqPGID-IAPRVSELTEAFVGSGDYVVMAVDLHETNDPYHPESSLFPPHNLRGTRGRELYGS 81
Cdd:cd01015 1 ALLVIDLVEGYTQPGSYLA-PGIAaALENVQRLLAAARAAGVPVIHTTVVYDPDGADGGLWARKVPAMSDLVEGSPLAAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 82 LNTVYEQNRESIywMDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGH 161
Cdd:cd01015 80 CDELAPQEDEMV--LVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVRECVGDRAPAPH 157
|
170
....*....|....*..
gi 518752642 162 SWALGHFRGSLGAgVVS 178
Cdd:cd01015 158 EANLFDIDNKYGD-VVS 173
|
|
| PLN02621 |
PLN02621 |
nicotinamidase |
3-161 |
8.34e-14 |
|
nicotinamidase
Pssm-ID: 178229 Cd Length: 197 Bit Score: 66.34 E-value: 8.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 3 ALIVIDFTNDF---VDGSLPVGQPGIDIAPRVSelteafvgsgdyVVMAVDLHETNDPY-HPESSLFPPHNL--RGTRGR 76
Cdd:PLN02621 22 ALLVIDMQNYFssmAEPILPALLTTIDLCRRAS------------IPVFFTRHSHKSPSdYGMLGEWWDGDLilDGTTEA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 77 ELYGSLNTVYEQNResiyWMDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASF 156
Cdd:PLN02621 90 ELMPEIGRVTGPDE----VVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATA 165
|
....*
gi 518752642 157 NPDGH 161
Cdd:PLN02621 166 NEELH 170
|
|
| PRK11609 |
PRK11609 |
bifunctional nicotinamidase/pyrazinamidase; |
2-148 |
1.65e-10 |
|
bifunctional nicotinamidase/pyrazinamidase;
Pssm-ID: 183228 Cd Length: 212 Bit Score: 57.69 E-value: 1.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 2 RALIVIDFTNDFV-DGSLPV--GQPGIDIAPRvseLTEAFVGSGDYVVMAVDLHETN----------DPYH-------PE 61
Cdd:PRK11609 3 RALLLVDLQNDFCaGGALAVpeGDSTIDVANR---LIDWCQSRGIPVIASQDWHPANhgsfasnhgaEPGTqgeldglPQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 62 SsLFPPHNLRGTRGRELYGSLNtvyeqnRESIYWM-------DKTRYSAF------SGTDLELKLRERGITELHLIGVCT 128
Cdd:PRK11609 80 T-WWPDHCVQNSEGAALHPLLN------QKAIDAVfhkgenpLIDSYSAFfdnghrQKTALDDWLREHGITELIVMGLAT 152
|
170 180
....*....|....*....|
gi 518752642 129 DICVLHTAVDAYNKGFSLTI 148
Cdd:PRK11609 153 DYCVKFTVLDALALGYQVNV 172
|
|
| isochorismatase |
cd01013 |
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ... |
96-165 |
2.94e-10 |
|
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.
Pssm-ID: 238495 Cd Length: 203 Bit Score: 56.58 E-value: 2.94e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 96 MDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHSWAL 165
Cdd:cd01013 120 LTKWRYSAFKRSPLLERLKESGRDQLIITGVYAHIGCLSTAVDAFMRDIQPFVVADAIADFSLEEHRMAL 189
|
|
| PLN02743 |
PLN02743 |
nicotinamidase |
4-153 |
4.20e-07 |
|
nicotinamidase
Pssm-ID: 215396 Cd Length: 239 Bit Score: 48.20 E-value: 4.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 4 LIVIDFTNDFVD---GSLPVGQPGIDIAPRVSE---LTEAFVGSGDYVVMAVDLHETNDPYHPesslFPPHNLRGTRGRE 77
Cdd:PLN02743 30 LVLVDEVNGFCTvgaGNLAPREPDKQISKMVDEsarLAREFCERKWPVLAFLDSHHPDKPEHP----YPPHCIVGTGEEN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 78 LYGSLNtvYEQNRESIYWMDKTRYSAF------SGTDLELK-LRERGITELHLIGVCTDICVLH---TAVDAYNKGFSLT 147
Cdd:PLN02743 106 LVPALQ--WLENDPNVTLRRKDCIDGFvgaiekDGSNVFVDwVNNNKIKVILVVGICTDICVLDfvaSALSARNHGILPP 183
|
....*.
gi 518752642 148 IhEDAV 153
Cdd:PLN02743 184 L-EDVV 188
|
|
| YcaC_related |
cd01012 |
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ... |
96-177 |
2.14e-06 |
|
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.
Pssm-ID: 238494 [Multi-domain] Cd Length: 157 Bit Score: 45.28 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518752642 96 MDKTRYSAFSGTDLELKLRERGITELHLIGVCTDICVLHTAVDAYNKGFSLTIHEDAVASFNPDGHSWALGHFRgslGAG 175
Cdd:cd01012 66 IEKTSFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELALARMR---QAG 142
|
..
gi 518752642 176 VV 177
Cdd:cd01012 143 AV 144
|
|
| |
