|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
1-986 |
0e+00 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 789.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 1 MKLINLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVkiENnlYRFIV 80
Cdd:PRK07135 1 MKLINLHTNTEYSFLSSTIKLDSLIKYAKENNLKTLVLTDHNNMFGVPKFYKLCKKNNIKPIIGLDLEV--EN--FRFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 81 YCQNKESFMNLKMLSLNYGKKGYIDLAEIrDYSNLIWIEHPIFGYYKKTNNILEIQNHYFAISQYDIDNSeiqnifdkcL 160
Cdd:PRK07135 77 LAKNYSGYKLLNELSSKKSKNKEIELNDL-DSDNIIIIDHPKNGFYAKNKEQLELKNYYINSNDPKIENA---------V 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 161 LINHNSILKYDDNSIIKTMSNISNNKIFESIYEEFkiDIETKNNSKLEELIERTNNFAKKLYFEIETKGFKMPKFKNDKN 240
Cdd:PRK07135 147 YVQERKLLFAEDNEYLKILNKIGNNKEENSNFKFF--DFEKWFEDIDEKILKRTNYLVENINIEFPKKEFNLPDFDNNLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 241 IASNEYLKLLLFKSIREKFDKYSWTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYL 320
Cdd:PRK07135 225 LESDLFLKKILKESVINKKAELKYYPNVKERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIGPGRGSASGSLVSYL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 321 LNITEVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAP 400
Cdd:PRK07135 305 LNITSVNPLKYDLLFERFLNPDRITMPDIDIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 401 TLINEISKNIENDeQDLLVEYNENRNLQLSLAKLnpnDESFSTRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQ 480
Cdd:PRK07135 385 SDVNAISKLIPNN-QSLEEAYDKNKSFFRELISK---GDPIYKKLYKIAKKLEGLPRQSGTHAAGIIISNKPITNYVPTF 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 481 YNSENFLQTQISMEYLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLK--INLKDIDLTDQKTLELLSSGHTRGVFQVE 558
Cdd:PRK07135 461 ESKDNYNQVQYSMEFLEDFGLLKIDLLGLKNLTIIKNIEEKINKELLFDhlINFNDLPIIDKKTNNLLSNGKTEGIFQLE 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 559 SPIMIKALRQVKVNNFEDIVAIISLNRPGPMKNVSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAK 638
Cdd:PRK07135 541 SPGMKSTIKKVGIDSFEDIVAIISLYRPGPIQYIPIYAKNKKNPKNIEKIHPEYDEIVAPTYGIIIYQEQIMQIAQKVAG 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 639 MTFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYP 718
Cdd:PRK07135 621 FSFAQADLLRRAISKKDETKLDKIKDKFIEGGIKNGYSKKVLEKIYSLIEKFADYGFNKSHAVAYATLAYKMAYYKANYP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 719 LEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRSKYGPYK 798
Cdd:PRK07135 701 LVFYSALISNSNGSQENIKKYVKEAKNNGIKVYSPDINFSTENAVFDNGKIFLPLIMIKGLGSVAIKKIIDERNKNGKYK 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 799 NFLDFLLKISSSqSIGKSTIELLIKANTLRSFNyNQNTLLN--EIQKNNTDTMLFiKMFKNNIEGVSPNIINSYKPSEIL 876
Cdd:PRK07135 781 NFFDFILRLKFI-GISKSIIEKLIKANTLRSFG-NQDTLLNnlELAKNYAETILS-KVAKNLYDDYKNFGLDLEFILEEI 857
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 877 NQDIMFEKKNEIELLGQVYNfNSSASNGMPGQTSFIDMHVGNEYLAIVNCTNIKQkISKKGNNYFELDLEANMQKIRAFY 956
Cdd:PRK07135 858 ERDLEEESKNEIEYLGMSFN-AFDTNKLEKNQIRLKDLRINTEYRLAIEVKNVKR-LRKANKEYKKVILSDDSVEITIFV 935
|
970 980 990
....*....|....*....|....*....|..
gi 518846655 957 FTSNQEILNV--KGKTIKVTLEKRNENIFYLR 986
Cdd:PRK07135 936 NDNDYLLFETlkKGDIYEFLISKSKNNKFYII 967
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
6-843 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 776.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 6 LHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV---KIENNLYRFIVYC 82
Cdd:COG0587 8 LHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVapgSRDDAGYHLVLLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 83 QNKESFMNL-KMLSL-----NYGKKGYIDLAEIRDYS-NLI----------------------------WIEhpIFG--Y 125
Cdd:COG0587 88 KNREGYRNLcRLLSRaylegFYKGKPRIDLEDLAEHSeGLIalsgclagevgqallagqydeaeaalarLKD--IFGdrF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 126 YkktnniLEIQNHYFAISQ------------YDI-------------DNSEIQNIfdkcLL-INHNSILkyDDnsiIKTM 179
Cdd:COG0587 166 Y------LELQRHGLPEDRrvnaallelareLGLplvatndvhylnpEDAEAHDV----LLcIRTGKTL--DD---PGRR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 180 SNISNNKIFES---IYEEFkidietknnSKLEELIERTNNFAKKLYFEIETKGFKMPKFKNDKNIASNEYLKLLLFKSIR 256
Cdd:COG0587 231 RFANAERYLKSpeeMAELF---------ADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLE 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 257 EKFDKYSwTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFE 336
Cdd:COG0587 302 RRYPEGI-PEEYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFE 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 337 RFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLINEISKNIENDEQD 416
Cdd:COG0587 381 RFLNPERVSMPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGI 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 417 LLVE-YNENRNLQlSLAKLNPNdesfSTRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQYNS-ENFLQTQISME 494
Cdd:COG0587 461 TLEKaLEEEPELR-ELYDSDPE----VRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAmGGRPVTQFDKD 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 495 YLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKALRQVKVNNF 574
Cdd:COG0587 536 DVEALGLLKFDFLGLRTLTVIRDALDLIKENRGIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCF 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 575 EDIVAIISLNRPGPMKNVSV--YAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADNLRRIIS 652
Cdd:COG0587 616 EDLVALVALYRPGPMQGGMVppYIRRKHGREPVEYPHPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMG 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 653 KKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISSAHGS 732
Cdd:COG0587 696 KKKKEEMAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMG 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 733 QDTIAKFVNEASECGVEIVSPDINLSESEAII-KNRKIILPLTLIKGLGPEIANSIVENRSKYGPYKNFLDFLLKISSSQ 811
Cdd:COG0587 776 FYKPAQYVQEARRHGIEVLPPDVNESDWDFTVePGGAIRLGLGAIKGVGEAAAEAIVAAREENGPFTSLFDFCRRVDLRK 855
|
890 900 910
....*....|....*....|....*....|..
gi 518846655 812 sIGKSTIELLIKANTLRSFNYNQNTLLNEIQK 843
Cdd:COG0587 856 -LNKRVLEALIKAGAFDSLGPNRRQLLWALEA 886
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
4-841 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 630.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 4 INLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV-----------KIE 72
Cdd:TIGR00594 2 VHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVapgsrfdkkriSKG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 73 NNLYRFIVYCQNKESFMNLKMLSLNYGKKGY-----IDLAEIRDYSN-LIWIEHPIFG---YYKKTNN-------ILEIQ 136
Cdd:TIGR00594 82 KEAYHLILLAKNNTGYRNLMKLSSLAYLEGFyykprIDKELLEEHSEgLIALSACLSGevpYLLLLGEerlaeeaALKYQ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 137 NH----YFaiSQYDIDNSEIQNIFDKCLL------------------INHNSILKYDDNSIIKTMSNISNNKIFESIYEE 194
Cdd:TIGR00594 162 EIfgddYY--LELQDHGIPEQRVVNEALLeiseelgiplvatndvhyINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 195 FKIDIETKNNSK---LEELIERTNNFAKKL-YFEIETKGFKMPKFKNDKNIASNE-YLKLLLFKSIREKF----DKYSWT 265
Cdd:TIGR00594 240 FYLKSPEEMAELfadIPEALANTVEIAERCnLVDVKLGPPRLPSYQIPPDFTSQEdYLRHLADEGLRERLaagpPGYKRR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 266 DEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFERFLNSNRVT 345
Cdd:TIGR00594 320 AQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNPERIS 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 346 MPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLINEISKNIENDEQDLLVEYNENr 425
Cdd:TIGR00594 400 MPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLKEALEA- 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 426 nlQLSLAKLNPNDESFSTrILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQYNSEN-FLQTQISMEYLEDFGLVKM 504
Cdd:TIGR00594 479 --SPQLRQLYEEDPEVKQ-LIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGgAISTQYDMDDLEAVGLLKM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 505 DILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKALRQVKVNNFEDIVAIISLN 584
Cdd:TIGR00594 556 DFLGLKTLTLIQDATELIRKRRGIDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAVNALY 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 585 RPGPMKN--VSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADNLRRIISKKKVNEMEDI 662
Cdd:TIGR00594 636 RPGPMESgmIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGKKKAEEMAKE 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 663 KSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISSAHGSQDTIAKFVNE 742
Cdd:TIGR00594 716 REKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDIEKVAVYIAE 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 743 ASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRSKYGPYKNFLDFLLKISSSqSIGKSTIELLI 822
Cdd:TIGR00594 796 AKKMGIEVLPPDINESGQDFAVEDKGIRYGLGAIKGVGESVVKSIIEERNKNGPFKSLFDFINRVDFK-KLNKKVLEALI 874
|
890
....*....|....*....
gi 518846655 823 KANTLRSFNYNQNTLLNEI 841
Cdd:TIGR00594 875 KAGAFDSLGPNRKTLLASL 893
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
245-508 |
5.12e-95 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 301.34 E-value: 5.12e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 245 EYLKLLLFKSIREKFDKySWTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNIT 324
Cdd:pfam07733 1 EYLRKLVEEGLKERYGE-GLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSLVAYLLGIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 325 EVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLIN 404
Cdd:pfam07733 80 EVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDEID 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 405 EISKNIENDEQDLLVEYNENRnlqlSLAKLNPNDESFStRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQY-NS 483
Cdd:pfam07733 160 RLAKLIPFELGILEKALEEEP----ELKELIESDPEVK-RLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKaDD 234
|
250 260
....*....|....*....|....*
gi 518846655 484 ENFLQTQISMEYLEDFGLVKMDILG 508
Cdd:pfam07733 235 DDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
5-118 |
5.42e-19 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 85.72 E-value: 5.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 5 NLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVKIENNLYRFIVYCQN 84
Cdd:cd07431 2 HLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTVEGDGEPYPLLLLAKN 81
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 518846655 85 KESFMNL------KMLSLNYGKKGYIDLAEIRDYSNLIWI 118
Cdd:cd07431 82 NEGYQNLlrlstaAMLGEEKDGVPYLDLEELAEAASGLLV 121
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
5-70 |
2.15e-11 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 59.97 E-value: 2.15e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518846655 5 NLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVK 70
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIV 66
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
1-986 |
0e+00 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 789.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 1 MKLINLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVkiENnlYRFIV 80
Cdd:PRK07135 1 MKLINLHTNTEYSFLSSTIKLDSLIKYAKENNLKTLVLTDHNNMFGVPKFYKLCKKNNIKPIIGLDLEV--EN--FRFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 81 YCQNKESFMNLKMLSLNYGKKGYIDLAEIrDYSNLIWIEHPIFGYYKKTNNILEIQNHYFAISQYDIDNSeiqnifdkcL 160
Cdd:PRK07135 77 LAKNYSGYKLLNELSSKKSKNKEIELNDL-DSDNIIIIDHPKNGFYAKNKEQLELKNYYINSNDPKIENA---------V 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 161 LINHNSILKYDDNSIIKTMSNISNNKIFESIYEEFkiDIETKNNSKLEELIERTNNFAKKLYFEIETKGFKMPKFKNDKN 240
Cdd:PRK07135 147 YVQERKLLFAEDNEYLKILNKIGNNKEENSNFKFF--DFEKWFEDIDEKILKRTNYLVENINIEFPKKEFNLPDFDNNLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 241 IASNEYLKLLLFKSIREKFDKYSWTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYL 320
Cdd:PRK07135 225 LESDLFLKKILKESVINKKAELKYYPNVKERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIGPGRGSASGSLVSYL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 321 LNITEVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAP 400
Cdd:PRK07135 305 LNITSVNPLKYDLLFERFLNPDRITMPDIDIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 401 TLINEISKNIENDeQDLLVEYNENRNLQLSLAKLnpnDESFSTRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQ 480
Cdd:PRK07135 385 SDVNAISKLIPNN-QSLEEAYDKNKSFFRELISK---GDPIYKKLYKIAKKLEGLPRQSGTHAAGIIISNKPITNYVPTF 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 481 YNSENFLQTQISMEYLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLK--INLKDIDLTDQKTLELLSSGHTRGVFQVE 558
Cdd:PRK07135 461 ESKDNYNQVQYSMEFLEDFGLLKIDLLGLKNLTIIKNIEEKINKELLFDhlINFNDLPIIDKKTNNLLSNGKTEGIFQLE 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 559 SPIMIKALRQVKVNNFEDIVAIISLNRPGPMKNVSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAK 638
Cdd:PRK07135 541 SPGMKSTIKKVGIDSFEDIVAIISLYRPGPIQYIPIYAKNKKNPKNIEKIHPEYDEIVAPTYGIIIYQEQIMQIAQKVAG 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 639 MTFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYP 718
Cdd:PRK07135 621 FSFAQADLLRRAISKKDETKLDKIKDKFIEGGIKNGYSKKVLEKIYSLIEKFADYGFNKSHAVAYATLAYKMAYYKANYP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 719 LEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRSKYGPYK 798
Cdd:PRK07135 701 LVFYSALISNSNGSQENIKKYVKEAKNNGIKVYSPDINFSTENAVFDNGKIFLPLIMIKGLGSVAIKKIIDERNKNGKYK 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 799 NFLDFLLKISSSqSIGKSTIELLIKANTLRSFNyNQNTLLN--EIQKNNTDTMLFiKMFKNNIEGVSPNIINSYKPSEIL 876
Cdd:PRK07135 781 NFFDFILRLKFI-GISKSIIEKLIKANTLRSFG-NQDTLLNnlELAKNYAETILS-KVAKNLYDDYKNFGLDLEFILEEI 857
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 877 NQDIMFEKKNEIELLGQVYNfNSSASNGMPGQTSFIDMHVGNEYLAIVNCTNIKQkISKKGNNYFELDLEANMQKIRAFY 956
Cdd:PRK07135 858 ERDLEEESKNEIEYLGMSFN-AFDTNKLEKNQIRLKDLRINTEYRLAIEVKNVKR-LRKANKEYKKVILSDDSVEITIFV 935
|
970 980 990
....*....|....*....|....*....|..
gi 518846655 957 FTSNQEILNV--KGKTIKVTLEKRNENIFYLR 986
Cdd:PRK07135 936 NDNDYLLFETlkKGDIYEFLISKSKNNKFYII 967
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
6-843 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 776.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 6 LHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV---KIENNLYRFIVYC 82
Cdd:COG0587 8 LHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVapgSRDDAGYHLVLLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 83 QNKESFMNL-KMLSL-----NYGKKGYIDLAEIRDYS-NLI----------------------------WIEhpIFG--Y 125
Cdd:COG0587 88 KNREGYRNLcRLLSRaylegFYKGKPRIDLEDLAEHSeGLIalsgclagevgqallagqydeaeaalarLKD--IFGdrF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 126 YkktnniLEIQNHYFAISQ------------YDI-------------DNSEIQNIfdkcLL-INHNSILkyDDnsiIKTM 179
Cdd:COG0587 166 Y------LELQRHGLPEDRrvnaallelareLGLplvatndvhylnpEDAEAHDV----LLcIRTGKTL--DD---PGRR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 180 SNISNNKIFES---IYEEFkidietknnSKLEELIERTNNFAKKLYFEIETKGFKMPKFKNDKNIASNEYLKLLLFKSIR 256
Cdd:COG0587 231 RFANAERYLKSpeeMAELF---------ADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLE 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 257 EKFDKYSwTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFE 336
Cdd:COG0587 302 RRYPEGI-PEEYRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFE 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 337 RFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLINEISKNIENDEQD 416
Cdd:COG0587 381 RFLNPERVSMPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGI 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 417 LLVE-YNENRNLQlSLAKLNPNdesfSTRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQYNS-ENFLQTQISME 494
Cdd:COG0587 461 TLEKaLEEEPELR-ELYDSDPE----VRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAmGGRPVTQFDKD 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 495 YLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKALRQVKVNNF 574
Cdd:COG0587 536 DVEALGLLKFDFLGLRTLTVIRDALDLIKENRGIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCF 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 575 EDIVAIISLNRPGPMKNVSV--YAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADNLRRIIS 652
Cdd:COG0587 616 EDLVALVALYRPGPMQGGMVppYIRRKHGREPVEYPHPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMG 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 653 KKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISSAHGS 732
Cdd:COG0587 696 KKKKEEMAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMG 775
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 733 QDTIAKFVNEASECGVEIVSPDINLSESEAII-KNRKIILPLTLIKGLGPEIANSIVENRSKYGPYKNFLDFLLKISSSQ 811
Cdd:COG0587 776 FYKPAQYVQEARRHGIEVLPPDVNESDWDFTVePGGAIRLGLGAIKGVGEAAAEAIVAAREENGPFTSLFDFCRRVDLRK 855
|
890 900 910
....*....|....*....|....*....|..
gi 518846655 812 sIGKSTIELLIKANTLRSFNYNQNTLLNEIQK 843
Cdd:COG0587 856 -LNKRVLEALIKAGAFDSLGPNRRQLLWALEA 886
|
|
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
4-838 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 638.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 4 INLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDV--------NVKIENNL 75
Cdd:PRK05673 3 VHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAyvapekkdDVSGGGAY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 76 YRFIVYCQNKESFMNL-KMLSL-----NYGKKGYIDLAEIRDYS-NLI----------------------------WIEh 120
Cdd:PRK05673 83 THLTLLAKNETGYRNLfKLSSRaylegQYGYKPRIDREWLAEHSeGLIalsgcpsgevgtallagqydeaeeaaaeYQE- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 121 pIFG--YYkktnniLEIQNHYFAI------------SQYDI-------------DNSEIQNIFdkcLLINHNSIL----- 168
Cdd:PRK05673 162 -IFGdrFY------LELMRHGLPIerrvehallelaKELGLplvatndvhyltpEDAEAHEAL---LCIAEGKTLddpdr 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 169 --KYDDNSIIKT---MSnisnnKIFesiyeefkidietknnSKLEELIERTNNFAKKLYFEIETKGFKMPKFKNDKNIAS 243
Cdd:PRK05673 232 frFYSPEQYLKSaeeMR-----ELF----------------ADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETE 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 244 NEYLKLLLFKSIREKFDKY---SWTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYL 320
Cdd:PRK05673 291 EDYLRKEAKEGLEERLAFLfpdEERPEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYA 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 321 LNITEVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAP 400
Cdd:PRK05673 371 LGITDLDPLRFGLLFERFLNPERVSMPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPY 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 401 TLINEISKNIEND-----------EQDLLVEYNENRNLQlslaklnpndesfstRILNQAARISGFYRQIGTHAAGLVIS 469
Cdd:PRK05673 451 GFVDRITKLIPPDpgitlakayeeEPELRELYESDPEVK---------------RLIDMARKLEGLTRNAGVHAAGVVIS 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 470 DQPVISIAPV--QYNSENfLQTQISMEYLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLS 547
Cdd:PRK05673 516 PTPLTDFVPLyrDPDSGM-PVTQFDMKDVEAAGLVKFDFLGLRTLTIIDDALKLIKKRRGIDVDLEAIPLDDPKTYELLQ 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 548 SGHTRGVFQVESPIMIKALRQVKVNNFEDIVAIISLNRPGPM--KNVSVYAKRKFGLESIPKINNEYDKILDSTYGIIVY 625
Cdd:PRK05673 595 RGETLGVFQLESRGMRDLLKRLKPDCFEDIIALVALYRPGPMesGMIPNFIDRKHGREEIEYPHPELEPILKETYGIIVY 674
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 626 QEQIMKIAQVVAKMTFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSI 705
Cdd:PRK05673 675 QEQVMQIAQVLAGYSLGGADLLRRAMGKKKPEEMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYAL 754
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 706 ITFQMAFLKAHYPLEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIAN 785
Cdd:PRK05673 755 VSYQTAYLKAHYPAEFMAALLTSDMDNTDKVAVYLDECRRMGIKVLPPDVNESLYDFTVVDGDIRYGLGAIKGVGEGAVE 834
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 518846655 786 SIVENRSKYGPYKNFLDFLLKISSSQsIGKSTIELLIKANTLRSFNYNQNTLL 838
Cdd:PRK05673 835 AIVEAREEGGPFKDLFDFCARVDLKK-VNKRVLESLIKAGAFDSLGPNRAALL 886
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
4-841 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 630.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 4 INLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV-----------KIE 72
Cdd:TIGR00594 2 VHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVapgsrfdkkriSKG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 73 NNLYRFIVYCQNKESFMNLKMLSLNYGKKGY-----IDLAEIRDYSN-LIWIEHPIFG---YYKKTNN-------ILEIQ 136
Cdd:TIGR00594 82 KEAYHLILLAKNNTGYRNLMKLSSLAYLEGFyykprIDKELLEEHSEgLIALSACLSGevpYLLLLGEerlaeeaALKYQ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 137 NH----YFaiSQYDIDNSEIQNIFDKCLL------------------INHNSILKYDDNSIIKTMSNISNNKIFESIYEE 194
Cdd:TIGR00594 162 EIfgddYY--LELQDHGIPEQRVVNEALLeiseelgiplvatndvhyINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 195 FKIDIETKNNSK---LEELIERTNNFAKKL-YFEIETKGFKMPKFKNDKNIASNE-YLKLLLFKSIREKF----DKYSWT 265
Cdd:TIGR00594 240 FYLKSPEEMAELfadIPEALANTVEIAERCnLVDVKLGPPRLPSYQIPPDFTSQEdYLRHLADEGLRERLaagpPGYKRR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 266 DEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFERFLNSNRVT 345
Cdd:TIGR00594 320 AQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNPERIS 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 346 MPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLINEISKNIENDEQDLLVEYNENr 425
Cdd:TIGR00594 400 MPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLKEALEA- 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 426 nlQLSLAKLNPNDESFSTrILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQYNSEN-FLQTQISMEYLEDFGLVKM 504
Cdd:TIGR00594 479 --SPQLRQLYEEDPEVKQ-LIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGgAISTQYDMDDLEAVGLLKM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 505 DILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKALRQVKVNNFEDIVAIISLN 584
Cdd:TIGR00594 556 DFLGLKTLTLIQDATELIRKRRGIDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAVNALY 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 585 RPGPMKN--VSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADNLRRIISKKKVNEMEDI 662
Cdd:TIGR00594 636 RPGPMESgmIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGKKKAEEMAKE 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 663 KSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISSAHGSQDTIAKFVNE 742
Cdd:TIGR00594 716 REKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDIEKVAVYIAE 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 743 ASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRSKYGPYKNFLDFLLKISSSqSIGKSTIELLI 822
Cdd:TIGR00594 796 AKKMGIEVLPPDINESGQDFAVEDKGIRYGLGAIKGVGESVVKSIIEERNKNGPFKSLFDFINRVDFK-KLNKKVLEALI 874
|
890
....*....|....*....
gi 518846655 823 KANTLRSFNYNQNTLLNEI 841
Cdd:TIGR00594 875 KAGAFDSLGPNRKTLLASL 893
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
1-946 |
0e+00 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 609.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 1 MKLINLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV----------K 70
Cdd:PRK06826 3 MSFVHLHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKQGIKPIIGCEVYVaprsrfdkepD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 71 IENNLYRFIVYCQNKESFMNL-KMLSLNYGKKGY----IDLAEIRDYSN-LIWI------EHP----------------- 121
Cdd:PRK06826 83 IDNETYHLVLLAKNETGYKNLmKIVSKAFTEGFYykprVDHELLKEHSEgLIALsaclagEVPryilkgnyekakeaalf 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 122 ---IFGyykKTNNILEIQNHYFA----ISQYDIDNSEIQNIfdkcLLINHNSI--LKYDDNSI------IKTMSNIS--N 184
Cdd:PRK06826 163 ykdIFG---KENFYLELQDHGIPeqrkVNEELIKLSKELGI----PLVATNDVhyIRKEDAKAhdvllcIQTGKTVDdeN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 185 NKIFESiyEEFKIdietKNNSKLEEL-------IERTNNFAKKLYFEIETKGFKMPKFKNDKNIASNEYLKLLLFKSIRE 257
Cdd:PRK06826 236 RMRFPS--DEFYL----KSPEEMYELfsyvpeaLENTVKIAERCNVEFEFGKSKLPKFPLPEGYDPYEYLRELCYEGLKK 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 258 KFDKYSwtDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFER 337
Cdd:PRK06826 310 RYPNPS--EELIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVGPGRGSAAGSLVAYTLGITKIDPIKYNLLFER 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 338 FLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILR--------INNIAPTLINEISKN 409
Cdd:PRK06826 388 FLNPERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGRalnypyaeVDRIAKMIPTELGIT 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 410 IE---NDEQDLLVEYNENRNLQlslaklnpndesfstRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQYNSENF 486
Cdd:PRK06826 468 IDkalELNPELKEAYENDERVR---------------ELIDTARALEGLPRHASTHAAGVVISSEPLVEYVPLQKNDGSI 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 487 LqTQISMEYLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKAL 566
Cdd:PRK06826 533 V-TQFTMTTLEELGLLKMDFLGLRTLTVIRDAVDLIKKNRGIEIDLDKIDYDDKKVYKMIGEGKTVGVFQLESAGMRSFM 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 567 RQVKVNNFEDIVAIISLNRPGPMKNVSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADN 646
Cdd:PRK06826 612 KELKPDSLEDIIAGISLYRPGPMDSIPRYIKNKNNPEKIEYLHPKLEPILKVTYGCIVYQEQVMQIVRDLAGYSMGRSDL 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 647 LRRIISKKKVNEMEDIKSIFIER--------AMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYP 718
Cdd:PRK06826 692 VRRAMSKKKHDVMEEERKNFIYGivdeggpgCIRNGIDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYYP 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 719 LEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRSKYGPYK 798
Cdd:PRK06826 772 VEFMAALLNSVMGNSDKVAFYIEECRRLGIEVLPPDINESYSKFTVEGDKIRFGLAAVKNVGENAIDSIVEEREKKGKFK 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 799 NFLDFLLKISSSQsIGKSTIELLIKANTLRSFNYNQNTLLN-------EIQKNNTDTM--------LFIKMFKNNIEGVS 863
Cdd:PRK06826 852 SLVDFCERVDTSQ-INKRAVESLIKAGAFDSLGVYRSQLLAvyekildSISKQRKKNIegqislfdLIGEEEESSLEIKY 930
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 864 PNiINSYKPSEILNqdimFEKkneiELLG----------------QVYNFNSSASNGMPGQTSFIDMHVGNEYL--AIVn 925
Cdd:PRK06826 931 PD-IKEFDKKELLA----MEK----EMLGlyisghpleeyeetlkKQTSATISDIISDEEEDGESKLKDGDKVIigGII- 1000
|
1050 1060
....*....|....*....|.
gi 518846655 926 cTNIKQKISKKGNNYFELDLE 946
Cdd:PRK06826 1001 -TEVKRKTTRNNEMMAFLTLE 1020
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
4-951 |
0e+00 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 557.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 4 INLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVKIENnlYRFIVYCQ 83
Cdd:PRK05898 3 INLNTHSHYSLLSSTLSIDDIIKFALDNNQPYVCLTDLNNLYGCIEFYDKAKAHNLIPIIGLEIEYQSTN--ATLVLYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 84 NKESFMNLKMLSLNYGKKGYIDLAEirDYSNLIWIEhpifgyyKKTNNILEIQNHYFAISQYDIDNSEIQNIFdkcllin 163
Cdd:PRK05898 81 NYNGYLNLIKISSFIMTNKEFEIQD--YLDDLFIVC-------KKGTFVFKSPNFYQTHNQNAPNAIAFNSVF------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 164 hnsILKYDDNSIIKTMSNISNNKIFESIYEEFKIDIET-KNNSKLEEL-----IERTNNFAKKLYFEIETKGFKMPKFKN 237
Cdd:PRK05898 145 ---YANKNDKIVFNAMLAIKNDLKIDELKNCQDFDNNHfLNDNEAQSLfspiqLDNLNKVLNELKVEIHDLPINIIKYDK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 238 DKNIASNEYLKLLLFKSIREKFD--KYSWTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGS 315
Cdd:PRK05898 222 QNSIISSEILKQLCISGLNKRLNanDGQVKKIYVKRLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIGPGRGSAAGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 316 LIGYLLNITEVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRI 395
Cdd:PRK05898 302 LIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDIDTDIMDERRDEVVEYLFEKYGNDHVAHIITFQRIKAKMAIRDVGRI 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 396 NNIAPTLINEISKNIEND-EQDLLVEYNENRNLQlSLAKLnpndesfSTRILNQAARISGFYRQIGTHAAGLVISDQPVI 474
Cdd:PRK05898 382 LGIDLKVIDKICKNIKPDyEEDLDLAIKKNTILK-EMYVL-------HKELFDLAKKIINAPRQIGTHAAGVVLSNSLLT 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 475 SIAPVQYNSENFLQTQISMEYLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGV 554
Cdd:PRK05898 454 NIIPIQLGINDRPLSQYSMEYLERFGLIKMDLLGLKNLTIIDNVLKLIKENQNKKIDLFNINLNDKNVFEDLAKGRTNGI 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 555 FQVESPIMIKALRQVKVNNFEDIVAIISLNRPGPMKNVSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQ 634
Cdd:PRK05898 534 FQLESPGMKKVLKKVKPQNIEDISIVSALFRPGPQQNIKTFVERRFKREEFSYWNEATKKILEPTHGIIVYQEQVINLVK 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 635 VVAKMTFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLK 714
Cdd:PRK05898 614 TIANFDIATADNFRRAISKKDEKILIQLKKDFIEGALKNNYKQPLVNQIFEYIFSFADYGFNHSHSLAYSYISYWMAYLK 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 715 AHYPLEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPDINLSESEAIIKNRK--IILPLTLIKGLGPEIANSIVENRS 792
Cdd:PRK05898 694 HYYPLEFLSILLSHTSASKDKLLSYLNEAKEFNISIKKPDINYSSNSFVLDTQKqiIRFGFNTIKGFGDELLKKIKSALQ 773
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 793 KyGPYKNFLDFLLKISSSqSIGKSTIELLIKANTLRSFNYNQNTLLNEIQKNNTDTMLFIKMFKNNIEGVSPNIINSYKP 872
Cdd:PRK05898 774 N-KTFSDFISYIDALKKN-NVSLSNIEILINVGTFDSFKLSRLFLLNNLPEIFEKTSLNGHFFELNLVGLEYAKDMSVKE 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 873 SeILNQDIMFEKKNEIELLGQVYNFNSSASNGMPGQTSFIDMHVGN---EYLAIVNCTNIKQKISKKGNNYFELDLEANM 949
Cdd:PRK05898 852 R-FLKKEIQYLGIDLNSLNYANYKNEIDYNELKYTIKDIKEIELKNtnyETNIFAQVYEIKQSKTKNGNLSFYLETLINN 930
|
..
gi 518846655 950 QK 951
Cdd:PRK05898 931 KK 932
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
1-841 |
8.93e-179 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 549.78 E-value: 8.93e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 1 MKLINLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVKIENN--LYRF 78
Cdd:PRK06920 1 MKFVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACKKHGIHPIIGLTASIFSEEEekSYPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 79 IVYCQNKESFMNLKMLS-------------------------LNYGKKGYI------DLAE-----IRDYSNliwiehpI 122
Cdd:PRK06920 81 VLLAENEIGYQNLLKISssimtkskegipkkwlahyakgliaISPGKDGEIeqllleDKESqaeevARAYQN-------M 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 123 FGYYKKTNNILEIQNHyFAISQYDIDNSEIQNI----FDKCLLINHNSILKYDDNSIIK--TMSNISNNKIFESIYEEFK 196
Cdd:PRK06920 154 FGNFYMSLQHHAIQDE-LLLQEKLPEFSNRVNIpvvaTNDVRYINQSDALVHECLLSVEsgTKMTDPDRPRLKTDQYYLK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 197 IDIETKN-NSKLEELIERTNNFAKKLYFEIETKGFKMPKFKNDKNIASNEYLKLLLFKSIREKFDkySWTDEYQQRFLKE 275
Cdd:PRK06920 233 SSDEMEAlFSHVPEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETADMYLRRVCEEGLQKRYG--TPKEVHINRLNHE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 276 LKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFERFLNSNRVTMPDIDIDVQD 355
Cdd:PRK06920 311 LNVISRMGFSDYFLIVWDFMKYAHENHILTGPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERVTLPDIDIDFPD 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 356 NKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLINEISKNIENDEQDLLVE-YNENRNLQLSLakl 434
Cdd:PRK06920 391 TRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKLIPSKLGITLKDaYEESQSLREFI--- 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 435 npNDESFSTRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQYNSENFLQTQISMEYLEDFGLVKMDILGLKTLTT 514
Cdd:PRK06920 468 --QGNLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAIQEGHNDVYVTQYPADALEELGLLKMDFLGLRNLTL 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 515 ISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKALRQVKVNNFEDIVAIISLNRPGPMKNVSV 594
Cdd:PRK06920 546 LENIIKFIEQKTGKEIDIRNLPLQDEKTFQLLGRGDTTGVFQLESSGMRNVLRGLKPNEFEDIVAVNSLYRPGPMEQIPT 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 595 YAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNG 674
Cdd:PRK06920 626 FIESKHGKRKIEYLHPDLKPILERTYGVIVYQEQIMQIASKLAGFSLGEADLLRRAVSKKNRDILDQERKHFVQGCLQNG 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 675 YEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPD 754
Cdd:PRK06920 706 YDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSSAIGNEDKIVQYIRETKRKGFHVLPPS 785
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 755 INLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRSKyGPYKNFLDFLLKIsSSQSIGKSTIELLIKANTLRSFNYNQ 834
Cdd:PRK06920 786 LQRSGYNFQIEGNAIRYSLLSIRNIGMATVTALYEEREK-KMFEDLFEFCLRM-PSKFVTERNLEAFVWSGCFDDFGVSR 863
|
....*..
gi 518846655 835 NTLLNEI 841
Cdd:PRK06920 864 TNLWKSL 870
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
10-839 |
1.72e-168 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 520.75 E-value: 1.72e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 10 TIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVKIENNLYRFIVYCQNKESFM 89
Cdd:PRK07279 9 TVYSFMDSLIDLEKYVERAKELGYQTIGIMDKDNLYGAYHFIEGAQKNGLQPILGLELNIFVEEQEVTLRLIAKNTQGYK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 90 NLKMLS--LNYGKKgyiDLAEIRDYSNLIWIehpIFGYYKKTNNILEIQNHYFAISQYDIdnseiQNIFDKCLLINHN-S 166
Cdd:PRK07279 89 NLLKIStaKMSGKK---QFSDLSQYLEGIAV---IVPYFDWSETLELPFDYYIGVDQETP-----GSDFKRPILPLRTvR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 167 ILKYDDNSIIKTMSNISNNKIFESI----YEEFKID---IETKNNSKLEELIERTNNFAKKLYFEIETKgFKMPKFknDK 239
Cdd:PRK07279 158 YFESADRETLQMLHAIRDNLSLREVplvsSDQELIScqsLETLFQERFPQALDNLEKLVSGISYDFDTD-LKLPRF--NR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 240 NIASNEYLKLLLFKSIREKFdkySWTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGY 319
Cdd:PRK07279 235 DRPAVEELRELAELGLKEKG---LWSSPYQERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYMGMGRGSAAGSLVAY 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 320 LLNITEVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIA 399
Cdd:PRK07279 312 ALDITGIDPVKHNLLFERFLNKERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGAKQAIRDVFKRFGVP 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 400 PTLINEISKNIENDEqDLLVEYNENRNLQlslAKLNPNDESfsTRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPV 479
Cdd:PRK07279 392 EYELSNLTKKISFRD-SLASVYEKNISFR---QIINSKLEY--QKAFEIAKRIEGNPRQTSIHAAGVVMSDDDLTNHIPL 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 480 QYnSENFLQTQISMEYLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVES 559
Cdd:PRK07279 466 KY-GDDMMITQYDAHAVEANGLLKMDFLGLRNLTFVQKMQEKVAKDYGIHIDIEAIDLEDKETLALFAAGDTKGIFQFEQ 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 560 PIMIKALRQVKVNNFEDIVAIISLNRPGPMKNVSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKM 639
Cdd:PRK07279 545 PGAINLLKRIKPVCFEDIVATTSLNRPGASDYTDNFVKRRHGQEKVDLIDPVIAPILEPTYGIMLYQEQVMQIAQVFAGF 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 640 TFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYPL 719
Cdd:PRK07279 625 SLGKADLLRRAMSKKNASEMQKMEEDFLQGALELGHSEEKARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPA 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 720 EFYTscISSAHGSQDTIAkfvnEASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRskygPYKN 799
Cdd:PRK07279 705 VFYD--IMLNYSSSDYIT----DALEFGFEVAKLSINTIPYHDKIENKKIYLGLKNIKGLPRDLAYWIIENR----PFSS 774
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 518846655 800 FLDFLLKIsSSQSIGKSTIELLIKANTLRSFNYNQNTLLN 839
Cdd:PRK07279 775 IEDFLTRL-PENYQKKEFLEPLIKIGLFDSFEKNRQKIIN 813
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
1-835 |
9.63e-159 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 498.86 E-value: 9.63e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 1 MKLINLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLD---VNVKIEN---- 73
Cdd:PRK07374 1 MAFVPLHNHSDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAIELLKLCKGKGIKPIIGNEmyvINGSIDDpqpk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 74 --NLYRFIVYCQNKESFMNL-KMLSLNY--GKKGY-------IDLAEIRDYSNLIWIEHPIFG----------------- 124
Cdd:PRK07374 81 keKRYHLVVLAKNATGYKNLvKLTTISHlnGMRGRgifsrpcIDKELLKQYSEGLIVSTACLGgeipqailrgrpdvard 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 125 ---YYKKT---NNILEIQNHYfaiSQYD-IDNSEIQNIFDK--------------------------CL----LINHNSI 167
Cdd:PRK07374 161 vaaWYKEVfgdDFYLEIQDHG---SIEDrIVNVELVRIAKElgikliatndahylskndveahdallCVltgkLISDEKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 168 LKYDDNSIIKTMSNIsnNKIFESIYEEFKIDIETKNNSKLEELIERTNNFAKklyfeietkgFKMPKFKNDKNIASNEYL 247
Cdd:PRK07374 238 LRYTGTEYIKSEEEM--LRLFRDHLDPEVIQEAIANTVEVAEKVEEYDILGT----------YRMPRFPIPEGHTAVSYL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 248 KLLLFKSIREKFDKYSWT---DEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNIT 324
Cdd:PRK07374 306 TEVTEQGLLKRLKLNSLDeidENYKERLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIPVGPGRGSAAGSLVAYALGIT 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 325 EVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLIN 404
Cdd:PRK07374 386 NIDPVKNGLLFERFLNPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQIITFNRMTSKAVLKDVARVLDIPYGEAD 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 405 EISKNIEndeqdllVEYNENRNLQLSLAKLNPNDE--------SFSTRILNQAARISGFYRQIGTHAAGLVISDQPVISI 476
Cdd:PRK07374 466 RLAKLIP-------VVRGKPAKLKAMIGKESPSPEfrekyekdPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDEL 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 477 APVQYNSENFLQTQISMEYLEDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQ 556
Cdd:PRK07374 539 VPLQRNNDGQVITQYFMEDIESLGLLKMDFLGLKNLTMIEKTLELVEQSTGERIDPDNLPLDDEKTFELLARGDLEGIFQ 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 557 VESPIMIKALRQVKVNNFEDIVAIISLNRPGPMKN--VSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQ 634
Cdd:PRK07374 619 LESSGMRQVVRDLKPSSLEDISSILALYRPGPLDAglIPKFINRKHGREAIDFAHPLLEPILTETYGIMVYQEQIMKIAQ 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 635 VVAKMTFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLK 714
Cdd:PRK07374 699 DLAGYSLGQADLLRRAMGKKKVSEMQKHRGIFVEGASKRGVDEKVADELFDQMVLFAEYCFNKSHSTAYGAVTYQTAYLK 778
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 715 AHYPLEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRSKY 794
Cdd:PRK07374 779 AHYPVAYMAALLTVNAGSSDKVQRYISNCNSMGIEVMPPDINRSGIDFTPKGNRILFGLSAVKNLGDGAIRNIIAARDSD 858
|
890 900 910 920
....*....|....*....|....*....|....*....|.
gi 518846655 795 GPYKNFLDFLLKISSSQsIGKSTIELLIKANTLRSFNYNQN 835
Cdd:PRK07374 859 GPFKSLADLCDRLPSNV-LNRRSLESLIHCGALDAFSPNAN 898
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
265-693 |
2.41e-108 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 356.74 E-value: 2.41e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 265 TDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFERFLNSNRV 344
Cdd:PRK09532 324 EPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIPVGPGRGSAAGSLVAYCLKITNIDPVHHGLLFERFLNPERK 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 345 TMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLINEISKNIEndeqdllVEYNEN 424
Cdd:PRK09532 404 SMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADKMAKLIP-------VSRGKP 476
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 425 RNLQLSLAKLNP--------NDESFSTRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQYNSENFLQTQISMEYL 496
Cdd:PRK09532 477 TKLKVMISDETPepefkekyDNDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQKNNDGAVITQYFMEDL 556
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 497 EDFGLVKMDILGLKTLTTISNIVDLIYQNQSLKINLKDIDLTD-------------------QKTLELLSSGHTRGVFQV 557
Cdd:PRK09532 557 ESLGLLKMDFLGLRNLTTIQKTADLIKENRGVEIDLDQLPLDErkalkilakgeakklpkdvQKTHKLLERGDLEGIFQL 636
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 558 ESPIMIKALRQVKVNNFEDIVAIISLNRPGPMKN--VSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQV 635
Cdd:PRK09532 637 ESSGMKQIVRDLKPSNIEDISSILALYRPGPLDAglIPKFINRKHGREPIDYEHQLLEPILNETYGVLVYQEQIMKMAQD 716
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 518846655 636 VAKMTFIEADNLRRIISKKKVNEMEDIKSIFIERAMKNGYEKSLATNIFNSIEKFASY 693
Cdd:PRK09532 717 LAGYSLGEADLLRRAMGKKKISEMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEY 774
|
|
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
209-830 |
4.08e-108 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 360.33 E-value: 4.08e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 209 ELIERTNNFAKKLYFEIETKGFKMPKFKNDKNIASNEYLKLLLFKSIREKFDKYSWTDEYQQrFLKELKVIEDLNFADYF 288
Cdd:PRK05672 254 EALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRYGPGIPPKARAQ-IEHELALIAELGYEGYF 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 289 LVVQDWVNWAKNNNIkIGPGRGSAAGSLIGYLLNITEVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKK 368
Cdd:PRK05672 333 LTVHDIVRFARSQGI-LCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPPDIDVDFEHDRREEVIQYVYRR 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 369 YGHEF---VANIVTFSSlgkKSAIRDILRINNIAPTLINEISKNIE--NDEQDLLVeynenrnlQLSLAKLNPNdesfsT 443
Cdd:PRK05672 412 YGRDRaaqVANVITYRP---RSAVRDVAKALGLSPGQVDAWAKQVSrwSGSADDLQ--------RLRQAGLDPE-----S 475
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 444 RILNQ----AARISGFYRQIGTHAAGLVISDQPVISIAPVqynsENflqtqISMEY----------LEDFGLVKMDILGL 509
Cdd:PRK05672 476 PIPRRvvelAAQLIGFPRHLSQHSGGFVICDRPLARLVPV----EN-----AAMEGrsviqwdkddCAAVGLVKVDVLAL 546
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 510 KTLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKALRQVKVNNFEDIVAIISLNRPGPM 589
Cdd:PRK05672 547 GMLSALHRAFDLIAEHRGRRLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVEVAIVRPGPI 626
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 590 KNVSV--YAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADNLRRII-SKKKVNEMEDIKSIF 666
Cdd:PRK05672 627 QGGMVhpYLRRRNGQEPVTYPHPELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMaAWRRKGRLERLRERL 706
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 667 IERAMKNGYEKSLATNIFNSIEKFASYGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISSA-HG--SQDTIakfVNEA 743
Cdd:PRK05672 707 YDGMLARGYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQpMGfySPQQL---VQDA 783
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 744 SECGVEIVSPDINLSESEAIIKNRK-----IILPLTLIKGLGPEIANSIVENRSKyGPYKNFLDFllkiSSSQSIGKSTI 818
Cdd:PRK05672 784 RRHGVEVLPVDVNASGWDATLEPLPdggpaVRLGLRLVRGLGEEAAERIVAARAR-GPFTSVEDL----ARRAGLDRRQL 858
|
650
....*....|..
gi 518846655 819 ELLIKANTLRSF 830
Cdd:PRK05672 859 EALADAGALRSL 870
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
245-508 |
5.12e-95 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 301.34 E-value: 5.12e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 245 EYLKLLLFKSIREKFDKySWTDEYQQRFLKELKVIEDLNFADYFLVVQDWVNWAKNNNIKIGPGRGSAAGSLIGYLLNIT 324
Cdd:pfam07733 1 EYLRKLVEEGLKERYGE-GLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAGSLVAYLLGIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 325 EVDPIKYDLIFERFLNSNRVTMPDIDIDVQDNKRNDVIEYLLKKYGHEFVANIVTFSSLGKKSAIRDILRINNIAPTLIN 404
Cdd:pfam07733 80 EVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDEID 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 405 EISKNIENDEQDLLVEYNENRnlqlSLAKLNPNDESFStRILNQAARISGFYRQIGTHAAGLVISDQPVISIAPVQY-NS 483
Cdd:pfam07733 160 RLAKLIPFELGILEKALEEEP----ELKELIESDPEVK-RLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKaDD 234
|
250 260
....*....|....*....|....*
gi 518846655 484 ENFLQTQISMEYLEDFGLVKMDILG 508
Cdd:pfam07733 235 DDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
511-674 |
2.31e-60 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 203.15 E-value: 2.31e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 511 TLTTISNIVDLIYQNQSLKINLKDIDLTDQKTLELLSSGHTRGVFQVESPIMIKALRQVKVNNFEDIVAIISLNRPGPMK 590
Cdd:pfam17657 1 TLTIIRDALDLIKENRGIGIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKPDTFEDLVALSALYRPGPMQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 591 --NVSVYAKRKFGLESIPKINNEYDKILDSTYGIIVYQEQIMKIAQVVAKMTFIEADNLRRIISKKKVNEMEDIKSIFIE 668
Cdd:pfam17657 81 ggNVDDYIKRKHGKEKIEYPHPDLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMGKKKPEEMEKLREKFIE 160
|
....*.
gi 518846655 669 RAMKNG 674
Cdd:pfam17657 161 GAKENG 166
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
747-837 |
1.20e-23 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 95.62 E-value: 1.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 747 GVEIVSPDINLSESEAIIKNRKIILPLTLIKGLGPEIANSIVENRsKYGPYKNFLDFLLKISSsqSIGKSTIELLIKANT 826
Cdd:pfam14579 1 GIEVLPPDINRSDWDFTVEGGGIRLGLGAIKGLGEAAAERIVEER-ENGPFKSLEDFARRVDL--KLNKRVLEALIKAGA 77
|
90
....*....|.
gi 518846655 827 LRSFNYNQNTL 837
Cdd:pfam14579 78 FDSLGGNRRQL 88
|
|
| PRK07373 |
PRK07373 |
DNA polymerase III subunit alpha; Reviewed |
691-962 |
4.81e-22 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 236003 [Multi-domain] Cd Length: 449 Bit Score: 100.52 E-value: 4.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 691 ASYGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISSAHGSQDTIAKFVNEASECGVEIVSPDINLSESEAIIKNRKII 770
Cdd:PRK07373 34 ASNCFNKSHSTAYAYVTYQTAYLKANYPVEYMAALLTANSGNQDKVQKYRENCQKMGIEVEPPDINRSGKDFTPVGEKIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 771 LPLTLIKGLGPEIANSIVENRSKYGPYKNFLDFLLKIsSSQSIGKSTIELLIKANTLRSFNYNQNTLLNEI-------QK 843
Cdd:PRK07373 114 FGLSAVRNLGEGAIESILKAREEGGEFKSLADFCDRV-DLRVVNRRALETLIYCGAFDKIEPNRQQLINDLelvidwaQK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 844 NNTD-----TMLFiKMFKNNIEGvSPNIINSYK--PSEILNQDIMFEKK--NEIELLG------QVYNFNSSASNGMPGQ 908
Cdd:PRK07373 193 RAKEkasgqGNLF-DLLGGNTSN-SSAANNAFEqaPSAPPVADFSLQEKlkLEKELLGfyvsehPLKSIRRPARLLSPIN 270
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 518846655 909 TSFIDMHVGNEYL-AIVNCTNIKQKISKKGNNYFELDLEANMQKIRAFYFTSNQE 962
Cdd:PRK07373 271 LSELEEQKEKTKVsAVVMLNEVKKIVTKKGDPMAFLQLEDLSGQSEAVVFPKSYE 325
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
5-118 |
5.42e-19 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 85.72 E-value: 5.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 5 NLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVKIENNLYRFIVYCQN 84
Cdd:cd07431 2 HLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTVEGDGEPYPLLLLAKN 81
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 518846655 85 KESFMNL------KMLSLNYGKKGYIDLAEIRDYSNLIWI 118
Cdd:cd07431 82 NEGYQNLlrlstaAMLGEEKDGVPYLDLEELAEAASGLLV 121
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
6-116 |
3.14e-17 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 80.28 E-value: 3.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 6 LHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV---------KIENNLY 76
Cdd:pfam02811 2 LHVHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKAGIKPIIGCEVYVapgsreeteKLLAKYF 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 518846655 77 RFIVYCQNKESFMNL-KMLSLNY--GKKGYIDLAEIRDYSNLI 116
Cdd:pfam02811 82 DLVLLAVHEVGYKNLiKLSSRAYleGFKPRIDKELLEEYFEGL 124
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
5-70 |
2.15e-11 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 59.97 E-value: 2.15e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518846655 5 NLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVK 70
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANIV 66
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
4-116 |
4.93e-10 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 61.72 E-value: 4.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 4 INLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVK---IENNLYRFIV 80
Cdd:cd07433 3 VHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVAnpdDADEPFRLTL 82
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 518846655 81 YCQNKESFMNL-KMLSLNY-----GKKGYIDLAEIRDYS-NLI 116
Cdd:cd07433 83 LAQNEQGYKNLtELISRAYlegqrNGGPHIKLEWLAEYSeGLI 125
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
6-138 |
1.87e-07 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 53.60 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 6 LHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV-----------KIENN 74
Cdd:cd12113 5 LHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCEVYVapgsrfdkkdkKGDKR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 75 LYRFIVYCQNKESFMNL-KMLSLNYgKKGY-----IDLAEIRDYSN-LI----------------------------WIE 119
Cdd:cd12113 85 YYHLVLLAKNEEGYRNLmKLVSLAY-LEGFyykprIDKELLAKYSEgLIalsaclageipqlllngdeeeareaaleYRD 163
|
170 180
....*....|....*....|..
gi 518846655 120 hpIFG---YYkktnniLEIQNH 138
Cdd:cd12113 164 --IFGkdnFY------LELQDH 177
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
693-837 |
2.80e-06 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 51.76 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 693 YGFNRSHAVSYSIITFQMAFLKAHYPLEFYTSCISS----------AHGSQD-----------------------TIAKF 739
Cdd:PRK00448 1261 YMFPKAHAAAYVLMAWRIAYFKVHYPLAYYAAYFSVraddfdletmSKGKEAikakmkeikskgndasnkekdllTVLEI 1340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 740 VNEASECGVEIVSPDINLSES-EAIIKNRKIILPLTLIKGLGPEIANSIVENRSKyGPYKNFLDFLLKISSSQSIgkstI 818
Cdd:PRK00448 1341 ALEMLERGFKFQKVDLYKSDAtEFIIEGDSLIPPFNALPGLGENVAKSIVEAREE-GEFLSKEDLRKRTKVSKTL----I 1415
|
170 180
....*....|....*....|
gi 518846655 819 ELLIKANTLRSFN-YNQNTL 837
Cdd:PRK00448 1416 EKLDELGVLDDLPeTNQLSL 1435
|
|
| ComEA |
COG1555 |
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ... |
773-821 |
3.65e-05 |
|
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];
Pssm-ID: 441164 [Multi-domain] Cd Length: 72 Bit Score: 42.54 E-value: 3.65e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 518846655 773 LTLIKGLGPEIANSIVENRSKYGPYKNFLDfLLKISssqSIGKSTIELL 821
Cdd:COG1555 23 LQTLPGIGPKLAQRIVEYREKNGPFKSVED-LLEVK---GIGPKTLEKL 67
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
2-69 |
8.99e-05 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 46.75 E-value: 8.99e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518846655 2 KLINLHLNTIFSFLESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV 69
Cdd:PRK00448 333 KRVELHLHTKMSTMDAIPSVSELVKRAAKWGHKAIAITDHGVVQAFPEAYNAAKKAGIKVIYGVEANL 400
|
|
| PHP_PolIIIA_POLC |
cd07435 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
4-96 |
1.34e-04 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; DNA polymerase III alphas (PolIIIAs) that contain a PHP domain have been classified into four basic groups based on phylogenetic and domain structural analyses: polC, dnaE1, dnaE2, and dnaE3. The PolC group is distinct from the other three and is clustered together. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in different location compare to dnaE1, 2, and 3. The PHP domain has four conserved sequence motifs and and contains an invariant histidine that is involved in metal ion coordination.The PHP domain of PolC is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. PHP domains found in dnaEs of thermophilic origin exhibit 3'-5' exonuclease activity. In contrast, PolC PHP lacks detectable nuclease activity.
Pssm-ID: 213990 [Multi-domain] Cd Length: 268 Bit Score: 44.77 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518846655 4 INLHLNTIFSFLESTITINDFIQELlnnniEYFG-----ITEHCNFYSMPYFLNEARKHDLKPIFGLDVNVKienNLYRF 78
Cdd:cd07435 2 VELHAHTKMSAMDGVTSVKELVKRA-----AEWGhkaiaITDHGVVQAFPEAYEAAKKNGIKVIYGVEAYLV---DPYHI 73
|
90
....*....|....*....
gi 518846655 79 IVYCQNKESFMNL-KMLSL 96
Cdd:cd07435 74 TILVKNQTGLKNLyKLVSL 92
|
|
| HHH_3 |
pfam12836 |
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain. |
773-821 |
5.77e-04 |
|
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
Pssm-ID: 463723 [Multi-domain] Cd Length: 62 Bit Score: 39.00 E-value: 5.77e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 518846655 773 LTLIKGLGPEIANSIVENRSKYGPYKNFLDfLLKISssqSIGKSTIELL 821
Cdd:pfam12836 14 LSRVPGLGPKLAKNIVEYREENGPFRSRED-LLKVK---GLGPKTFEQL 58
|
|
| PHP_HisPPase |
cd07432 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase ... |
4-69 |
1.14e-03 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. HisPPase can be classified into two types: the bifunctional HisPPase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213987 [Multi-domain] Cd Length: 129 Bit Score: 39.92 E-value: 1.14e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518846655 4 INLHLNTIFSFlESTITINDFIQELLNNNIEYFGITEHCNFYSMPYFLNEARKHDLKPIFGLDVNV 69
Cdd:cd07432 1 ADLHIHSVFSP-DSDMTPEEIVERAIELGLDGIAITDHNTIDGAEEALKEAYKDGLLVIPGVEVTL 65
|
|
| |
