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Conserved domains on  [gi|518884688|ref|WP_020040563|]
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glycosyltransferase family 2 protein [Salipiger mucosus]

Protein Classification

glycosyltransferase( domain architecture ID 11440269)

glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  9334165|16037492|12691742|10521532
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 4-309 6.42e-20

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


:

Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 87.87  E-value: 6.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   4 VDVVLIGRNEGARLVAALAA------TRGARQVVYVDSGSRDDSVARAREAGATVVE---LDRSAPFTAARARNAGFAAL 74
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSllaqdyPKEKLEVIVVDDGSTDETAEIARELAAEYPRvrvIERPENGGKAAALNAGLKAA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  75 EApDLVQFVDGDCALVPGWLDAGRAHLdAHPELAlvtgwraeihrdaslynqladaewrrpagqirACGGDMMVRAAAFR 154
Cdd:COG1215  111 RG-DIVVFLDADTVLDPDWLRRLVAAF-ADPGVG--------------------------------ASGANLAFRREALE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688 155 AVGGFDPGVIAaEDDEFCTRLRKTGGQLERLPQEMTRHDAdMHHFGQWWRRAVRTGHGFAQVGHLHPDYFVAERRRVLAY 234
Cdd:COG1215  157 EVGGFDEDTLG-EDLDLSLRLLRAGYRIVYVPDAVVYEEA-PETLRALFRQRRRWARGGLQLLLKHRPLLRPRRLLLFLL 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518884688 235 ALALPLAILLAATFSGWLALAMAALYPLNWWRTaqglsrdglpkpeARRQAVLLTLSKFPNLIGMATFHLRRLRR 309
Cdd:COG1215  235 LLLLPLLLLLLLLALLALLLLLLPALLLALLLA-------------LRRRRLLLPLLHLLYGLLLLLAALRGKKV 296
 
Name Accession Description Interval E-value
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 4-309 6.42e-20

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 87.87  E-value: 6.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   4 VDVVLIGRNEGARLVAALAA------TRGARQVVYVDSGSRDDSVARAREAGATVVE---LDRSAPFTAARARNAGFAAL 74
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSllaqdyPKEKLEVIVVDDGSTDETAEIARELAAEYPRvrvIERPENGGKAAALNAGLKAA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  75 EApDLVQFVDGDCALVPGWLDAGRAHLdAHPELAlvtgwraeihrdaslynqladaewrrpagqirACGGDMMVRAAAFR 154
Cdd:COG1215  111 RG-DIVVFLDADTVLDPDWLRRLVAAF-ADPGVG--------------------------------ASGANLAFRREALE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688 155 AVGGFDPGVIAaEDDEFCTRLRKTGGQLERLPQEMTRHDAdMHHFGQWWRRAVRTGHGFAQVGHLHPDYFVAERRRVLAY 234
Cdd:COG1215  157 EVGGFDEDTLG-EDLDLSLRLLRAGYRIVYVPDAVVYEEA-PETLRALFRQRRRWARGGLQLLLKHRPLLRPRRLLLFLL 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518884688 235 ALALPLAILLAATFSGWLALAMAALYPLNWWRTaqglsrdglpkpeARRQAVLLTLSKFPNLIGMATFHLRRLRR 309
Cdd:COG1215  235 LLLLPLLLLLLLLALLALLLLLLPALLLALLLA-------------LRRRRLLLPLLHLLYGLLLLLAALRGKKV 296
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-180 1.70e-17

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 77.93  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   6 VVLIGRNEGARLVAAL----AATRGARQVVYVDSGSRDDSVARAREAGAT---VVELDRSAPFTAARARNAGFAALEApD 78
Cdd:cd00761    1 VIIPAYNEEPYLERCLesllAQTYPNFEVIVVDDGSTDGTLEILEEYAKKdprVIRVINEENQGLAAARNAGLKAARG-E 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  79 LVQFVDGDCALVPGWLDAGRAHLDAHPELALVTGWraeihrdaslynqladaewrrpagqiracgGDMMVRAAAFRAVGG 158
Cdd:cd00761   80 YILFLDADDLLLPDWLERLVAELLADPEADAVGGP------------------------------GNLLFRRELLEEIGG 129

                        170       180
                 ....*....|....*....|..
gi 518884688 159 FDPGVIAAEDDEFCTRLRKTGG 180
Cdd:cd00761  130 FDEALLSGEEDDDFLLRLLRGG 151
Glyco_transf_7C pfam02709
N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of ...
 123-193 2.56e-07

N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 460659 [Multi-domain]  Cd Length: 78  Bit Score: 47.61  E-value: 2.56e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518884688  123 LYNQLADAEWRRPAGQIraCGGDMMVRAAAFRAVGGFDPGVIA--AEDDEFCTRLRKTGGQLERLPQE-----MTRHD 193
Cdd:pfam02709   3 LSVALDKFGYKLPYKTY--FGGVLALSREDFERINGFSNGFWGwgGEDDDLYNRLLLAGLEIERPPGDigryyMLYHK 78
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 1-86 5.67e-06

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 47.22  E-value: 5.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   1 MSAVDVVLIGRNEG---ARLVAALAATRGAR---QVVYVDSGSRDDSVARAREAGATVVELDRSAPFTAAR-----ARNA 69
Cdd:PRK13915  30 GRTVSVVLPALNEEetvGKVVDSIRPLLMEPlvdELIVIDSGSTDATAERAAAAGARVVSREEILPELPPRpgkgeALWR 109

                         90
                 ....*....|....*..
gi 518884688  70 GFAALEApDLVQFVDGD 86
Cdd:PRK13915 110 SLAATTG-DIVVFVDAD 125
 
Name Accession Description Interval E-value
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 4-309 6.42e-20

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 87.87  E-value: 6.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   4 VDVVLIGRNEGARLVAALAA------TRGARQVVYVDSGSRDDSVARAREAGATVVE---LDRSAPFTAARARNAGFAAL 74
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSllaqdyPKEKLEVIVVDDGSTDETAEIARELAAEYPRvrvIERPENGGKAAALNAGLKAA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  75 EApDLVQFVDGDCALVPGWLDAGRAHLdAHPELAlvtgwraeihrdaslynqladaewrrpagqirACGGDMMVRAAAFR 154
Cdd:COG1215  111 RG-DIVVFLDADTVLDPDWLRRLVAAF-ADPGVG--------------------------------ASGANLAFRREALE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688 155 AVGGFDPGVIAaEDDEFCTRLRKTGGQLERLPQEMTRHDAdMHHFGQWWRRAVRTGHGFAQVGHLHPDYFVAERRRVLAY 234
Cdd:COG1215  157 EVGGFDEDTLG-EDLDLSLRLLRAGYRIVYVPDAVVYEEA-PETLRALFRQRRRWARGGLQLLLKHRPLLRPRRLLLFLL 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518884688 235 ALALPLAILLAATFSGWLALAMAALYPLNWWRTaqglsrdglpkpeARRQAVLLTLSKFPNLIGMATFHLRRLRR 309
Cdd:COG1215  235 LLLLPLLLLLLLLALLALLLLLLPALLLALLLA-------------LRRRRLLLPLLHLLYGLLLLLAALRGKKV 296
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-205 3.13e-19

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 83.89  E-value: 3.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   1 MSAVDVVLIGRNEGARLVAALAA----TRGARQVVYVDSGSRDDSVARARE---AGATVVELDRSAPFtaARARNAGFAA 73
Cdd:COG1216    2 RPKVSVVIPTYNRPELLRRCLESllaqTYPPFEVIVVDNGSTDGTAELLAAlafPRVRVIRNPENLGF--AAARNLGLRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  74 LEApDLVQFVDGDCALVPGWLDAgrahldahpelalvtgwraeihrdaslynqladaewrrpagQIRACGgdMMVRAAAF 153
Cdd:COG1216   80 AGG-DYLLFLDDDTVVEPDWLER-----------------------------------------LLAAAC--LLIRREVF 115

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 518884688 154 RAVGGFDPGV-IAAEDDEFCTRLRKTGGQLERLPQEMTRHDADmHHFGQWWRR 205
Cdd:COG1216  116 EEVGGFDERFfLYGEDVDLCLRLRKAGYRIVYVPDAVVYHLGG-ASSGPLLRA 167
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-180 1.70e-17

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 77.93  E-value: 1.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   6 VVLIGRNEGARLVAAL----AATRGARQVVYVDSGSRDDSVARAREAGAT---VVELDRSAPFTAARARNAGFAALEApD 78
Cdd:cd00761    1 VIIPAYNEEPYLERCLesllAQTYPNFEVIVVDDGSTDGTLEILEEYAKKdprVIRVINEENQGLAAARNAGLKAARG-E 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  79 LVQFVDGDCALVPGWLDAGRAHLDAHPELALVTGWraeihrdaslynqladaewrrpagqiracgGDMMVRAAAFRAVGG 158
Cdd:cd00761   80 YILFLDADDLLLPDWLERLVAELLADPEADAVGGP------------------------------GNLLFRRELLEEIGG 129

                        170       180
                 ....*....|....*....|..
gi 518884688 159 FDPGVIAAEDDEFCTRLRKTGG 180
Cdd:cd00761  130 FDEALLSGEEDDDFLLRLLRGG 151
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 16-192 1.42e-16

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 75.67  E-value: 1.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  16 RLVAALAATRGAR-QVVYVDSGSRDDSVARAREAGATVVELDRSAPFTAARARNAGFAALEApDLVQFVDGDCALVPGWL 94
Cdd:cd04186   14 ACLDSLLAQTYPDfEVIVVDNASTDGSVELLRELFPEVRLIRNGENLGFGAGNNQGIREAKG-DYVLLLNPDTVVEPGAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  95 DAGRAHLDAHPELALVTGwraeihrdaslynqladaewrrpagqiRACGGDMMVRAAAFRAVGGFDPGVIAA-EDDEFCT 173
Cdd:cd04186   93 LELLDAAEQDPDVGIVGP---------------------------KVSGAFLLVRREVFEEVGGFDEDFFLYyEDVDLCL 145

                        170
                 ....*....|....*....
gi 518884688 174 RLRKTGGQLERLPQEMTRH 192
Cdd:cd04186  146 RARLAGYRVLYVPQAVIYH 164
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 4-206 1.08e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 74.35  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   4 VDVVLIGRNEGARLVAAL----AATRGARQVVYVDSGSRDDSVARAREAGA-----TVVELDRsaPFTAARARNAGFAAL 74
Cdd:COG0463    4 VSVVIPTYNEEEYLEEALesllAQTYPDFEIIVVDDGSTDGTAEILRELAAkdpriRVIRLER--NRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  75 EApDLVQFVDGDCALVPGWLDAGRAHLDAHPElALVTGWRAeIHRDASLYNQLADAEW---RRPAGQIRACGGDMMVRAA 151
Cdd:COG0463   82 RG-DYIAFLDADDQLDPEKLEELVAALEEGPA-DLVYGSRL-IREGESDLRRLGSRLFnlvRLLTNLPDSTSGFRLFRRE 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518884688 152 AFRAVgGFDPGVIaaEDDEFcTRLRKTGGQLERLPQEMTRHDaDMHHFGQWWRRA 206
Cdd:COG0463  159 VLEEL-GFDEGFL--EDTEL-LRALRHGFRIAEVPVRYRAGE-SKLNLRDLLRLL 208
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 12-190 8.31e-14

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 69.52  E-value: 8.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  12 NEGARLVAALAATR----GARQVVYVDSGSRDDSVARAREAGATVVeldRSAPftaARAR--NAGfAALEAPDLVQFVDG 85
Cdd:cd02522    9 NEAENLPRLLASLRrlnpLPLEIIVVDGGSTDGTVAIARSAGVVVI---SSPK---GRARqmNAG-AAAARGDWLLFLHA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  86 DCALVPGWLDAGRAHLDAHPELAlvTGWRAEIHRDASLYN---QLADAEWRRPagqiRACGGD--MMVRAAAFRAVGGFD 160
Cdd:cd02522   82 DTRLPPDWDAAIIETLRADGAVA--GAFRLRFDDPGPRLRlleLGANLRSRLF----GLPYGDqgLFIRRELFEELGGFP 155

                        170       180       190
                 ....*....|....*....|....*....|
gi 518884688 161 PGVIaAEDDEFCTRLRKTgGQLERLPQEMT 190
Cdd:cd02522  156 ELPL-MEDVELVRRLRRR-GRPALLPSPVT 183
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 11-168 1.72e-11

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 61.86  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  11 RNEGA---RLVAALAA-TRGARQVVYVDSGSRDDSVARAREAGA----TVVELDRSAPFTAARARNAGFAALEaPDLVQF 82
Cdd:cd06423    6 YNEEAvieRTIESLLAlDYPKLEVIVVDDGSTDDTLEILEELAAlyirRVLVVRDKENGGKAGALNAGLRHAK-GDIVVV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  83 VDGDCALVPGWLDAGRAHLDAHPELALVTGWRAEIHRDASLYNQLADAEWRRPAGQIRA-----------CGGDMMVRAA 151
Cdd:cd06423   85 LDADTILEPDALKRLVVPFFADPKVGAVQGRVRVRNGSENLLTRLQAIEYLSIFRLGRRaqsalggvlvlSGAFGAFRRE 164

                        170
                 ....*....|....*..
gi 518884688 152 AFRAVGGFDPGVIaAED 168
Cdd:cd06423  165 ALREVGGWDEDTL-TED 180
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 4-222 6.24e-08

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 52.62  E-value: 6.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   4 VDVVLIGRNEGA---RLVAALAATR---GARQVVYVDSGSRDDS---VARAREAGATVVELDRSAPFTAArARNAGFAAL 74
Cdd:cd02525    2 VSIIIPVRNEEKyieELLESLLNQSypkDLIEIIVVDGGSTDGTreiVQEYAAKDPRIRLIDNPKRIQSA-GLNIGIRNS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  75 EApDLVQFVDGDCALVPGWLdAGRAHLDAHPELALVTGWRAEIHRDASLYNqLADAE----------WRRPAGQIR---- 140
Cdd:cd02525   81 RG-DIIIRVDAHAVYPKDYI-LELVEALKRTGADNVGGPMETIGESKFQKA-IAVAQssplgsggsaYRGGAVKIGyvdt 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688 141 ACGGdmMVRAAAFRAVGGFDPGVIAAEDDEFCTRLRKTGGQLERLPqemtrhDADMHH-----FGQWWRRAVRTGHGFAQ 215
Cdd:cd02525  158 VHHG--AYRREVFEKVGGFDESLVRNEDAELNYRLRKAGYKIWLSP------DIRVYYyprstLKKLARQYFRYGKWRAR 229


                 ....*..
gi 518884688 216 VGHLHPD 222
Cdd:cd02525  230 TLRKHRK 236
Glyco_transf_7C pfam02709
N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of ...
 123-193 2.56e-07

N-terminal domain of galactosyltransferase; This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalyzed reaction.


Pssm-ID: 460659 [Multi-domain]  Cd Length: 78  Bit Score: 47.61  E-value: 2.56e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518884688  123 LYNQLADAEWRRPAGQIraCGGDMMVRAAAFRAVGGFDPGVIA--AEDDEFCTRLRKTGGQLERLPQE-----MTRHD 193
Cdd:pfam02709   3 LSVALDKFGYKLPYKTY--FGGVLALSREDFERINGFSNGFWGwgGEDDDLYNRLLLAGLEIERPPGDigryyMLYHK 78
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-171 3.68e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 50.36  E-value: 3.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   6 VVLIGRNEG---ARLVAALAA---TRGARQVVYVDSGSRDDSV----ARAREAGATVVELDRSAPFtAARARNAGFAALE 75
Cdd:cd04192    1 VVIAARNEAenlPRLLQSLSAldyPKEKFEVILVDDHSTDGTVqileFAAAKPNFQLKILNNSRVS-ISGKKNALTTAIK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  76 AP--DLVQFVDGDCALVPGWLDAG-RAHLDAHPELAL--VTGWRAEihrdaSLYNQLADAEWRRPAGQIRA--------- 141
Cdd:cd04192   80 AAkgDWIVTTDADCVVPSNWLLTFvAFIQKEQIGLVAgpVIYFKGK-----SLLAKFQRLDWLSLLGLIAGsfglgkpfm 154

                        170       180       190
                 ....*....|....*....|....*....|..
gi 518884688 142 C-GGDMMVRAAAFRAVGGFDP-GVIAAEDDEF 171
Cdd:cd04192  155 CnGANMAYRKEAFFEVGGFEGnDHIASGDDEL 186
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-154 1.17e-06

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 47.77  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688    5 DVVLIGRNEGARLVAALAA----TRGARQVVYVDSGSRDDSVARAREA-----GATVVELDRsaPFTAARARNAGFAALE 75
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESllnqTYPNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPE--NRGKAGARNAGLRAAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   76 ApDLVQFVDGDCALVPGWLDAGRAHLDAHPeLALVTGWRAEIHRDASLYNQLADAEWRRPAGQIR----------ACGGD 145
Cdd:pfam00535  79 G-DYIAFLDADDEVPPDWLEKLVEALEEDG-ADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGlrllglnlpfLIGGF 156


                  ....*....
gi 518884688  146 MMVRAAAFR 154
Cdd:pfam00535 157 ALYRREALE 165
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 14-192 2.33e-06

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 47.75  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   14 GARLVAALAATRGARQVVYVDSGSRDDSVARAREAGA--------TVVELDRSAPFTAARARNAGFAAlEAPDLVQFVDG 85
Cdd:pfam13641  18 GRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEIAArfpdvrlrVIRNARLLGPTGKSRGLNHGFRA-VKSDLVVLHDD 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   86 DCALVPGWLDAgRAHLDAHPELALVTGwRAEIHRDASLYNQLADAEW----------RRPAGQIRACGGDMMVRAAAFRA 155
Cdd:pfam13641  97 DSVLHPGTLKK-YVQYFDSPKVGAVGT-PVFSLNRSTMLSALGALEFalrhlrmmslRLALGVLPLSGAGSAIRREVLKE 174

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 518884688  156 VGGFDPGVIAAEDDEFCTRLRKTGGQLERLPQEMTRH 192
Cdd:pfam13641 175 LGLFDPFFLLGDDKSLGRRLRRHGWRVAYAPDAAVRT 211
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 1-86 5.67e-06

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 47.22  E-value: 5.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   1 MSAVDVVLIGRNEG---ARLVAALAATRGAR---QVVYVDSGSRDDSVARAREAGATVVELDRSAPFTAAR-----ARNA 69
Cdd:PRK13915  30 GRTVSVVLPALNEEetvGKVVDSIRPLLMEPlvdELIVIDSGSTDATAERAAAAGARVVSREEILPELPPRpgkgeALWR 109

                         90
                 ....*....|....*..
gi 518884688  70 GFAALEApDLVQFVDGD 86
Cdd:PRK13915 110 SLAATTG-DIVVFVDAD 125
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 61-193 1.14e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 46.12  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688   61 FTAARARNAGFAALEApDLVQFVDGDCALVPGWLD-----AGRAHLDAHPELALVTGWRAEIHRDASLYNQLADAEWR-- 133
Cdd:pfam10111  67 YSLAASRNRGTSHAIG-EYISFIDGDCLWSPDKFEkqlkiATSLALQENIQAAVVLPVTDLNDESSNFLRRGGDLTASgd 145

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518884688  134 ----------RPAGQIRACGGDMMVRAAAFRAVGGFDPGVI--AAEDDEFCTRLRKTGGQLERLPQEMTRHD 193
Cdd:pfam10111 146 vlrdllvfysPLAIFFAPNSSNALINRQAFIEVGGFDESFRghGAEDFDIFLRLAARYPFVAVMPPQLLYRL 217
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 61-185 3.32e-04

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 40.64  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  61 FTAARARNAGFAALEApDLVQFVDGDCALVPGWldagrahLDAHPELA----LVTGWRAEIHRdaslynQLADAEWRrpa 136
Cdd:cd06420   65 FRKAKIRNKAIAAAKG-DYLIFIDGDCIPHPDF-------IADHIELAepgvFLSGSRVLLNE------KLTERGIR--- 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 518884688 137 gqiracGGDMMVRAAAFRAVGGFDPGVI--AAEDDEFCTRLRKTGGQLERL 185
Cdd:cd06420  128 ------GCNMSFWKKDLLAVNGFDEEFTgwGGEDSELVARLLNSGIKFRKL 172
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 12-86 4.26e-03

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 37.55  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518884688  12 NEGARLVAALAATRGARQ------VVYVDSGSRDDSVARAREAGATVVE---LDRSAPFTAARARNAGFAALEApDLVQF 82
Cdd:cd04179    7 NEEENIPELVERLLAVLEegydyeIIVVDDGSTDGTAEIARELAARVPRvrvIRLSRNFGKGAAVRAGFKAARG-DIVVT 85


                 ....
gi 518884688  83 VDGD 86
Cdd:cd04179   86 MDAD 89
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 143-191 5.48e-03

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 37.32  E-value: 5.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 518884688  143 GGDMMVRAAAFRAVGGFDPGVIaAEDDEFCTRLRKTGGQLERLPQEMTR 191
Cdd:pfam13632  74 GSGAFLRRSALQEVGGWDDGSV-SEDFDFGLRLQRAGYRVRFAPYSAVY 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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