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Conserved domains on  [gi|518916813|ref|WP_020072688|]
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amino acid ABC transporter permease [Faecalispora sporosphaeroides]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-215 1.30e-73

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 221.87  E-value: 1.30e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   1 MDFEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLG 80
Cdd:COG0765    3 FDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  81 VVISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSV 160
Cdd:COG0765   83 IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518916813 161 FSVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRLRYA 215
Cdd:COG0765  163 VSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-215 1.30e-73

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 221.87  E-value: 1.30e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   1 MDFEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLG 80
Cdd:COG0765    3 FDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  81 VVISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSV 160
Cdd:COG0765   83 IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518916813 161 FSVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRLRYA 215
Cdd:COG0765  163 VSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 2-212 3.53e-34

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 121.11  E-value: 3.53e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813    2 DFEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGV 81
Cdd:TIGR03003   2 DWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   82 VISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVF 161
Cdd:TIGR03003  82 RLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 518916813  162 SVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRL 212
Cdd:TIGR03003 162 SAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 1-213 9.84e-34

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 120.16  E-value: 9.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   1 MDFEF--IRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPK 78
Cdd:PRK09494   1 MQFDWsaIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  79 L--GVVISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIK 156
Cdd:PRK09494  81 AfnDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 518916813 157 ETSVFSVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRLR 213
Cdd:PRK09494 161 DTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRMK 217
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 17-203 3.68e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 3.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  17 ALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGVVISSES---CAVIGL 93
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  94 AFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFSVVALADLMYVA 173
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 518916813 174 KDLIGLYYKTDEALFLLVTSYLVILLPISI 203
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 31-214 7.74e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 58.85  E-value: 7.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   31 SFLLGLFCSLiqyYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFgLPKLGVVISSESCAVIGLAFLGGSYMAEAFRSGLE 110
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  111 SVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFSVVALADLMYVAKDLIGLYYKTDE---AL 187
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEiqgPV 156

                         170       180
                  ....*....|....*....|....*..
gi 518916813  188 FLLVTSYLVILLPISIASSLLERRLRY 214
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-215 1.30e-73

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 221.87  E-value: 1.30e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   1 MDFEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLG 80
Cdd:COG0765    3 FDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  81 VVISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSV 160
Cdd:COG0765   83 IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518916813 161 FSVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRLRYA 215
Cdd:COG0765  163 VSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 1-212 2.30e-45

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 150.25  E-value: 2.30e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   1 MDFEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLG 80
Cdd:COG4160    1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  81 VVISSE---------SCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANV 151
Cdd:COG4160   81 WVRESWlwpllrdpwFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEV 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518916813 152 IFLIKETSVFSVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRL 212
Cdd:COG4160  161 ILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRL 221
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 2-212 3.53e-34

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 121.11  E-value: 3.53e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813    2 DFEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGV 81
Cdd:TIGR03003   2 DWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   82 VISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVF 161
Cdd:TIGR03003  82 RLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 518916813  162 SVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRL 212
Cdd:TIGR03003 162 SAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 1-213 9.84e-34

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 120.16  E-value: 9.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   1 MDFEF--IRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPK 78
Cdd:PRK09494   1 MQFDWsaIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  79 L--GVVISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIK 156
Cdd:PRK09494  81 AfnDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 518916813 157 ETSVFSVVALADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRLR 213
Cdd:PRK09494 161 DTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRMK 217
PRK15100 PRK15100
cystine ABC transporter permease;
3-169 1.03e-31

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 115.23  E-value: 1.03e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   3 FEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGVV 82
Cdd:PRK15100   5 IQLVIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  83 ISSESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFS 162
Cdd:PRK15100  85 LDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAA 164


                 ....*..
gi 518916813 163 VVALADL 169
Cdd:PRK15100 165 TIQVPEL 171
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 10-213 4.03e-29

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 108.01  E-value: 4.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   10 VPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGVVISSESCA 89
Cdd:TIGR03004   4 LPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVTTG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   90 VIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFSVVALADL 169
Cdd:TIGR03004  84 VMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADL 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 518916813  170 MYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERRLR 213
Cdd:TIGR03004 164 TFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVR 207
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 9-107 2.90e-26

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 97.22  E-value: 2.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813    9 NVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGVVISSESC 88
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTA 80

                          90
                  ....*....|....*....
gi 518916813   89 AVIGLAFLGGSYMAEAFRS 107
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIFRG 99
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 17-203 3.68e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 3.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  17 ALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGVVISSES---CAVIGL 93
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  94 AFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFSVVALADLMYVA 173
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 518916813 174 KDLIGLYYKTDEALFLLVTSYLVILLPISI 203
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
PRK15069 PRK15069
histidine ABC transporter permease HisM;
21-211 3.44e-16

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 74.32  E-value: 3.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  21 LRIALW----GVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGVVISSE---------- 86
Cdd:PRK15069  23 LAITLWllvaSVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVRGTDlldaffrsgl 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  87 SCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFSVVAL 166
Cdd:PRK15069 103 NCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATV 182

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 518916813 167 ADLMYVAKDLIGLYYKTDEALFLLVTSYLVILLPISIASSLLERR 211
Cdd:PRK15069 183 PDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERR 227
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 20-172 6.70e-16

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 75.18  E-value: 6.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  20 TLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFG------------------------ 75
Cdd:COG4597   95 TLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFAvlealpsprqslslfdgvflnnrg 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  76 ------------------------------------------------------------------------LPKL---- 79
Cdd:COG4597  175 lylpapvfepgfgwvlaallaaivaafvlrrwarrrqeatgqrfpvwwislallvglpllaflllgaplsldYPELkgfn 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  80 ---GVVISSESCA-VIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLI 155
Cdd:COG4597  255 frgGLTLSPEFVAlLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLT 334

                        250
                 ....*....|....*..
gi 518916813 156 KETSVFSVVALADLMYV 172
Cdd:COG4597  335 KNSSLAVAIGYPDLVSV 351
artM PRK11122
arginine ABC transporter permease ArtM;
3-211 1.97e-15

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 71.91  E-value: 1.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   3 FEFIRQNVPMYQTAALLTLRialwGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFG------- 75
Cdd:PRK11122   2 LEYLPELLKGLHTSLTLTVA----SLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqfpwl 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  76 --LPKLGVVISSE-SCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRyVVLPQALSVSVPALCANVI 152
Cdd:PRK11122  78 qeYPWLWHLLSQPwLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVV 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518916813 153 FLIKETSVFSVVALADLMYVAKDLIGLYYKT-----DEALFLLVTSYLVILLpisiasSLLERR 211
Cdd:PRK11122 157 LVFKSTSLAYTITLMDVMGYSQLLYGRTYDVmvfgaAGIIYLVVNGLLTLLM------RLIERK 214
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
2-211 2.89e-15

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 71.78  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   2 DFEFIRQNVPMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPK--- 78
Cdd:PRK15107   5 DWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGflq 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  79 --LGVVISSE---SCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIF 153
Cdd:PRK15107  85 nvLGLSPKTDirlISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIV 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 518916813 154 LIKETSVFSVVALADLMYVAkDLIGLYYKTDEALFLLVTS-YLVILLPISIASSLLERR 211
Cdd:PRK15107 165 LFQDTSLVYVLSLADFFRTA-STIGERDGTQVEMILFAGFvYFVISLSASLLVSYLKKR 222
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
15-174 8.64e-15

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 70.48  E-value: 8.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  15 TAALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLPKLGVVISSE-------- 86
Cdd:PRK11123   9 SAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGSSQLLLTLSDGftlnlgfv 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  87 ----------------SCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCAN 150
Cdd:PRK11123  89 qipvqmdienfevspfLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQ 168

                        170       180
                 ....*....|....*....|....
gi 518916813 151 VIFLIKETSVFSVVALADLMYVAK 174
Cdd:PRK11123 169 WLVLLKDTALVSLISVNDLMLQTK 192
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
17-170 8.56e-13

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 65.20  E-value: 8.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  17 ALLTLRIALWGVLFSFLLGLFCSLIQYYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFGLP--------KLGVV---ISS 85
Cdd:PRK15135  13 ALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQialnsvteALGVGqidIDP 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  86 ESCAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFSVVA 165
Cdd:PRK15135  93 MVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLLG 172


                 ....*
gi 518916813 166 LADLM 170
Cdd:PRK15135 173 LEDVV 177
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 31-214 7.74e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 58.85  E-value: 7.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   31 SFLLGLFCSLiqyYKVPVLRRIIGVYIELSRNTPLLVQLFFLYFgLPKLGVVISSESCAVIGLAFLGGSYMAEAFRSGLE 110
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  111 SVEKGQLEAGLSIGLGHSQIIRYVVLPQALSVSVPALCANVIFLIKETSVFSVVALADLMYVAKDLIGLYYKTDE---AL 187
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEiqgPV 156

                         170       180
                  ....*....|....*....|....*..
gi 518916813  188 FLLVTSYLVILLPISIASSLLERRLRY 214
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 11-140 2.75e-07

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 49.76  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813  11 PMYQTAALLTLRIALWGVLFSFLLGLFCSLIQYYkVPVLRRIIGVYIELSRNTPL--LVQLFFLYFGLPKLGVVIssesC 88
Cdd:COG0600   57 GELWEHLLASLLRVLLGFALAALLGVPLGLLLGL-SRLLRRLLDPLLVFLRPIPPlaLAPLLILWFGIGEASKIF----V 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 518916813  89 AVIGLAFlggsYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQAL 140
Cdd:COG0600  132 IFLGAFF----PILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAAL 179
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 2-140 1.30e-06

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 47.38  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   2 DFEFIrqnvPMYQTAALLTLRIALWGVLFSFLLGLFCSLI---QYYKVPVLRRIIGVYIELSRNTP-LLVQLFFLY-FGL 76
Cdd:COG3639   42 DWSYL----PDLLSALLETLAIALLGTLLGAVLALPLAFLaarNLAPNPWVRLLARRLLNVLRAIPeLVWALIFVAaVGL 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518916813  77 PKLGvvissescAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQAL 140
Cdd:COG3639  118 GPFA--------GVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVL 173
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 10-140 1.89e-06

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 47.15  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518916813   10 VPMYQTAALLTLRIALWGVLFSFLLGLFCSLI---QYYKVPVLRRIIGVYIELSRNTP-LLVQLFFLY-FGLPKLGvvis 84
Cdd:TIGR01097  53 LPRILKALLETLAMAILGTVLAAVLAVPLALLaarNITPSPWLYGLARLLLNFLRAIPeLVWALIFVAaVGLGPFA---- 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 518916813   85 sescAVIGLAFLGGSYMAEAFRSGLESVEKGQLEAGLSIGLGHSQIIRYVVLPQAL 140
Cdd:TIGR01097 129 ----GVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVL 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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