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Conserved domains on  [gi|518920728|ref|WP_020076603|]
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N-acetylmannosamine-6-phosphate 2-epimerase [Cryocola sp. 340MFSha3.1]

Protein Classification

N-acetylmannosamine-6-phosphate 2-epimerase( domain architecture ID 10789899)

N-acetylmannosamine-6-phosphate 2-epimerase converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NanE COG3010
Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism];
23-239 2.95e-76

Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism];


:

Pssm-ID: 442247  Cd Length: 226  Bit Score: 229.99  E-value: 2.95e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  23 LAAIEGGLVVSCQAQQGSPMRDTATIARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDE 101
Cdd:COG3010    4 LEQLKGGLIVSCQALPGEPLHSPEIMAAMALAAVQGGAVGIRANGVEDIRAIKKAVDLPIIGIIKRDYPDSDVyITPTLE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 102 QVLALAAAGadvvavdatAE-VAGDVASRVRSAVLAVP-----------LPIMADASTLDEGLAAWDAGATFVGTTLSGY 169
Cdd:COG3010   84 EVDALAEAG---------ADiIALDATRRPRPDGETLAeliariheepgALVMADISTLEEALAAAELGADIVGTTLSGY 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518920728 170 TPYSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRFAAATPR 239
Cdd:COG3010  155 TGETKGTDGPDLELLKELVAAlGVPVIAEGRIHTPEQAAAALELGAHAVVVGTAITRPELITKRFVDALKK 225
 
Name Accession Description Interval E-value
NanE COG3010
Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism];
23-239 2.95e-76

Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism];


Pssm-ID: 442247  Cd Length: 226  Bit Score: 229.99  E-value: 2.95e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  23 LAAIEGGLVVSCQAQQGSPMRDTATIARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDE 101
Cdd:COG3010    4 LEQLKGGLIVSCQALPGEPLHSPEIMAAMALAAVQGGAVGIRANGVEDIRAIKKAVDLPIIGIIKRDYPDSDVyITPTLE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 102 QVLALAAAGadvvavdatAE-VAGDVASRVRSAVLAVP-----------LPIMADASTLDEGLAAWDAGATFVGTTLSGY 169
Cdd:COG3010   84 EVDALAEAG---------ADiIALDATRRPRPDGETLAeliariheepgALVMADISTLEEALAAAELGADIVGTTLSGY 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518920728 170 TPYSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRFAAATPR 239
Cdd:COG3010  155 TGETKGTDGPDLELLKELVAAlGVPVIAEGRIHTPEQAAAALELGAHAVVVGTAITRPELITKRFVDALKK 225
PRK01130 PRK01130
putative N-acetylmannosamine-6-phosphate 2-epimerase;
25-236 6.75e-70

putative N-acetylmannosamine-6-phosphate 2-epimerase;


Pssm-ID: 234907  Cd Length: 221  Bit Score: 213.47  E-value: 6.75e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  25 AIEGGLVVSCQAQQGSPMRDTATIARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDEQV 103
Cdd:PRK01130   2 QLKGGLIVSCQALPGEPLHSPEIMAAMALAAVQGGAVGIRANGVEDIKAIRAVVDVPIIGIIKRDYPDSEVyITPTLKEV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 104 LALAAAGadvvavdatAEV-AGDVASRVRSAVLAVP-----------LPIMADASTLDEGLAAWDAGATFVGTTLSGYTP 171
Cdd:PRK01130  82 DALAAAG---------ADIiALDATLRPRPDGETLAelvkrikeypgQLLMADCSTLEEGLAAQKLGFDFIGTTLSGYTE 152
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518920728 172 YSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRFAAA 236
Cdd:PRK01130 153 ETKKPEEPDFALLKELLKAvGCPVIAEGRINTPEQAKKALELGAHAVVVGGAITRPEEITKWFVDA 218
NanE cd04729
N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to ...
23-233 4.45e-64

N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of related sugars that are found as a component of glycoproteins, gangliosides, and other sialoglycoconjugates.


Pssm-ID: 240080 [Multi-domain]  Cd Length: 219  Bit Score: 198.57  E-value: 4.45e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  23 LAAIEGGLVVSCQAQQGSPMRDTATIARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDE 101
Cdd:cd04729    4 LEQLKGGLIVSCQALPGEPLHSPEIMAAMALAAVQGGAVGIRANGVEDIRAIRARVDLPIIGLIKRDYPDSEVyITPTIE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 102 QVLALAAAGADVvavdataeVAGDVASRVRSAVLAVP-----------LPIMADASTLDEGLAAWDAGATFVGTTLSGYT 170
Cdd:cd04729   84 EVDALAAAGADI--------IALDATDRPRPDGETLAelikriheeynCLLMADISTLEEALNAAKLGFDIIGTTLSGYT 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518920728 171 PYSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRF 233
Cdd:cd04729  156 EETAKTEDPDFELLKELRKAlGIPVIAEGRINSPEQAAKALELGADAVVVGSAITRPEHITGWF 219
NanE pfam04131
Putative N-acetylmannosamine-6-phosphate epimerase; This family represents a putative ...
48-237 5.35e-40

Putative N-acetylmannosamine-6-phosphate epimerase; This family represents a putative ManNAc-6-P-to-GlcNAc-6P epimerase in the N-acetylmannosamine (ManNAc) utilization pathway found mainly in pathogenic bacteria.


Pssm-ID: 427732  Cd Length: 192  Bit Score: 136.41  E-value: 5.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728   48 IARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDEQVLALAAAGADVvavdataeVAGDV 126
Cdd:pfam04131   1 VSAMALAAEQAGAVGIRIEGVNNLKATRAVVDVPIIGIVKRDLPDSPVrITPFMKDIDELANAGADI--------IALDG 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  127 ASRVRsavlavPLPI--------------MADASTLDEGLAAWDAGATFVGTTLSGYTPYSRMDPgPDIELVAELASRGV 192
Cdd:pfam04131  73 TSRPR------PVTIedfikrikekgclaMADCSTFEEGLNADKLGVDIIGTTLSGYTGGENPAE-PDFQLVKTLSEAGC 145
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 518920728  193 RVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRFAAAT 237
Cdd:pfam04131 146 FVIAEGRYNTPELAKKAIEIGADAVTVGSAITRLEHITQWFNNAI 190
 
Name Accession Description Interval E-value
NanE COG3010
Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism];
23-239 2.95e-76

Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism];


Pssm-ID: 442247  Cd Length: 226  Bit Score: 229.99  E-value: 2.95e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  23 LAAIEGGLVVSCQAQQGSPMRDTATIARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDE 101
Cdd:COG3010    4 LEQLKGGLIVSCQALPGEPLHSPEIMAAMALAAVQGGAVGIRANGVEDIRAIKKAVDLPIIGIIKRDYPDSDVyITPTLE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 102 QVLALAAAGadvvavdatAE-VAGDVASRVRSAVLAVP-----------LPIMADASTLDEGLAAWDAGATFVGTTLSGY 169
Cdd:COG3010   84 EVDALAEAG---------ADiIALDATRRPRPDGETLAeliariheepgALVMADISTLEEALAAAELGADIVGTTLSGY 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518920728 170 TPYSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRFAAATPR 239
Cdd:COG3010  155 TGETKGTDGPDLELLKELVAAlGVPVIAEGRIHTPEQAAAALELGAHAVVVGTAITRPELITKRFVDALKK 225
PRK01130 PRK01130
putative N-acetylmannosamine-6-phosphate 2-epimerase;
25-236 6.75e-70

putative N-acetylmannosamine-6-phosphate 2-epimerase;


Pssm-ID: 234907  Cd Length: 221  Bit Score: 213.47  E-value: 6.75e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  25 AIEGGLVVSCQAQQGSPMRDTATIARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDEQV 103
Cdd:PRK01130   2 QLKGGLIVSCQALPGEPLHSPEIMAAMALAAVQGGAVGIRANGVEDIKAIRAVVDVPIIGIIKRDYPDSEVyITPTLKEV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 104 LALAAAGadvvavdatAEV-AGDVASRVRSAVLAVP-----------LPIMADASTLDEGLAAWDAGATFVGTTLSGYTP 171
Cdd:PRK01130  82 DALAAAG---------ADIiALDATLRPRPDGETLAelvkrikeypgQLLMADCSTLEEGLAAQKLGFDFIGTTLSGYTE 152
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518920728 172 YSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRFAAA 236
Cdd:PRK01130 153 ETKKPEEPDFALLKELLKAvGCPVIAEGRINTPEQAKKALELGAHAVVVGGAITRPEEITKWFVDA 218
NanE cd04729
N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to ...
23-233 4.45e-64

N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of related sugars that are found as a component of glycoproteins, gangliosides, and other sialoglycoconjugates.


Pssm-ID: 240080 [Multi-domain]  Cd Length: 219  Bit Score: 198.57  E-value: 4.45e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  23 LAAIEGGLVVSCQAQQGSPMRDTATIARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDE 101
Cdd:cd04729    4 LEQLKGGLIVSCQALPGEPLHSPEIMAAMALAAVQGGAVGIRANGVEDIRAIRARVDLPIIGLIKRDYPDSEVyITPTIE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 102 QVLALAAAGADVvavdataeVAGDVASRVRSAVLAVP-----------LPIMADASTLDEGLAAWDAGATFVGTTLSGYT 170
Cdd:cd04729   84 EVDALAAAGADI--------IALDATDRPRPDGETLAelikriheeynCLLMADISTLEEALNAAKLGFDIIGTTLSGYT 155
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518920728 171 PYSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRF 233
Cdd:cd04729  156 EETAKTEDPDFELLKELRKAlGIPVIAEGRINSPEQAAKALELGADAVVVGSAITRPEHITGWF 219
NanE pfam04131
Putative N-acetylmannosamine-6-phosphate epimerase; This family represents a putative ...
48-237 5.35e-40

Putative N-acetylmannosamine-6-phosphate epimerase; This family represents a putative ManNAc-6-P-to-GlcNAc-6P epimerase in the N-acetylmannosamine (ManNAc) utilization pathway found mainly in pathogenic bacteria.


Pssm-ID: 427732  Cd Length: 192  Bit Score: 136.41  E-value: 5.35e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728   48 IARLAASALQGGAVALRVNGPDDVSAVRPLSDVPVIGLDKRMGPRRNI-ITPTDEQVLALAAAGADVvavdataeVAGDV 126
Cdd:pfam04131   1 VSAMALAAEQAGAVGIRIEGVNNLKATRAVVDVPIIGIVKRDLPDSPVrITPFMKDIDELANAGADI--------IALDG 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728  127 ASRVRsavlavPLPI--------------MADASTLDEGLAAWDAGATFVGTTLSGYTPYSRMDPgPDIELVAELASRGV 192
Cdd:pfam04131  73 TSRPR------PVTIedfikrikekgclaMADCSTFEEGLNADKLGVDIIGTTLSGYTGGENPAE-PDFQLVKTLSEAGC 145
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 518920728  193 RVLAEGRFQTPEQVSRAFDAGAFAVVVGGAITDPIAITRRFAAAT 237
Cdd:pfam04131 146 FVIAEGRYNTPELAKKAIEIGADAVTVGSAITRLEHITQWFNNAI 190
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
129-221 1.60e-03

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 38.34  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518920728 129 RVRSAVLAVPLPIMADASTLDEGLAAWDAGATFVGTTLSGYTPYSRMDPGPDIELVAELASR-GVRVLAEGRFQTPEQVS 207
Cdd:cd04722  107 ELREAVPDVKVVVKLSPTGELAAAAAEEAGVDEVGLGNGGGGGGGRDAVPIADLLLILAKRGsKVPVIAGGGINDPEDAA 186
                         90
                 ....*....|....
gi 518920728 208 RAFDAGAFAVVVGG 221
Cdd:cd04722  187 EALALGADGVIVGS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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