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Conserved domains on  [gi|518998921|ref|WP_020154796|]
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glucose-6-phosphate dehydrogenase [Caldibacillus debilis]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11417513)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 9-500 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 853.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   9 ALIQTNTPATLVLlFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETF---GMPQEKIG 85
Cdd:COG0364    2 TQMRPAEPCDLVI-FGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFsrkPFDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  86 KFIRHFYFQSHDVTDENSYRELKGLADELDEKYAaNGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWD 165
Cdd:COG0364   81 RFLERLHYVSGDFTDPEGYERLKELLEELDEERT-PGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 166 LSSAVELNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGAL 245
Cdd:COG0364  160 LASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 246 RDMVQNHMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVHKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSN 325
Cdd:COG0364  240 RDMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDST 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 326 TETFVAGKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSG 405
Cdd:COG0364  320 TETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPG 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 406 RTMETTPVKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEA 485
Cdd:COG0364  400 LGMRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEA 479

                        490
                 ....*....|....*
gi 518998921 486 ADELLQRDGFFWWPI 500
Cdd:COG0364  480 ADALLARDGRSWREP 494
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 9-500 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 853.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   9 ALIQTNTPATLVLlFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETF---GMPQEKIG 85
Cdd:COG0364    2 TQMRPAEPCDLVI-FGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFsrkPFDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  86 KFIRHFYFQSHDVTDENSYRELKGLADELDEKYAaNGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWD 165
Cdd:COG0364   81 RFLERLHYVSGDFTDPEGYERLKELLEELDEERT-PGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 166 LSSAVELNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGAL 245
Cdd:COG0364  160 LASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 246 RDMVQNHMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVHKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSN 325
Cdd:COG0364  240 RDMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDST 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 326 TETFVAGKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSG 405
Cdd:COG0364  320 TETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPG 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 406 RTMETTPVKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEA 485
Cdd:COG0364  400 LGMRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEA 479

                        490
                 ....*....|....*
gi 518998921 486 ADELLQRDGFFWWPI 500
Cdd:COG0364  480 ADALLARDGRSWREP 494
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 10-500 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 846.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  10 LIQTNTPATLVLlFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETF---GMPQEKIGK 86
Cdd:PRK05722   3 LPRTAEPCDLVI-FGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFartPFDEEVWER 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  87 FIRHFYFQSHDVTDENSYRELKGLADELDEKYAANGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWDL 166
Cdd:PRK05722  82 FLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 167 SSAVELNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALR 246
Cdd:PRK05722 162 ASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 247 DMVQNHMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVHKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSNT 326
Cdd:PRK05722 242 DMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTT 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 327 ETFVAGKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSGR 406
Cdd:PRK05722 322 ETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGE 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 407 TMETTPVKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEAA 486
Cdd:PRK05722 402 GMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAA 481

                        490
                 ....*....|....
gi 518998921 487 DELLQRDGFFWWPI 500
Cdd:PRK05722 482 DALLARDGRSWREP 495
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 16-500 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 701.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   16 PATLVLLFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETF--GMPQEKIGKFIRHFYF 93
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFetDEIDEQWDEFAQRLSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   94 QSHDVTDENSYRELKGLADELDEKYAANGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWDLSSAVELN 173
Cdd:TIGR00871  81 VSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  174 ERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQNHM 253
Cdd:TIGR00871 161 KALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  254 LQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDvhKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSNTETFVAGK 333
Cdd:TIGR00871 241 LQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALK 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  334 LMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRNGSSLNP-NLLVIHIQPEEGITLHLNVKKSGRTMETTP 412
Cdd:TIGR00871 319 LEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETRP 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  413 VKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEK-ADFPNYAAGTFGPEAADELLQ 491
Cdd:TIGR00871 399 VKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKgPSPPNYPAGSWGPKEADELIR 478


                  ....*....
gi 518998921  492 RDGFFWWPI 500
Cdd:TIGR00871 479 KDGRSWRKP 487
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
202-498 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 528.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  202 VIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQNHMLQIVSLLAMEPPIRLTTDEIRSEKVKVL 281
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  282 RALHPIEKKDVHKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSNTETFVAGKLMIDNFRWAGVPFYIRTGKRMQAKTLKI 361
Cdd:pfam02781  82 RSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  362 VVQFKDIPMNLyYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSGRTMETTPVKLNFSNKNVDGINTPEAYEKLLYDILRG 441
Cdd:pfam02781 162 RIQFKDVPHNL-FRDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 518998921  442 DATNFTHWDEVAYSWNFVDPISEAWAEEKadFPNYAAGTFGPEAADELLQRDGFFWW 498
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 9-500 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 853.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   9 ALIQTNTPATLVLlFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETF---GMPQEKIG 85
Cdd:COG0364    2 TQMRPAEPCDLVI-FGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFsrkPFDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  86 KFIRHFYFQSHDVTDENSYRELKGLADELDEKYAaNGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWD 165
Cdd:COG0364   81 RFLERLHYVSGDFTDPEGYERLKELLEELDEERT-PGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 166 LSSAVELNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGAL 245
Cdd:COG0364  160 LASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 246 RDMVQNHMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVHKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSN 325
Cdd:COG0364  240 RDMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDST 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 326 TETFVAGKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSG 405
Cdd:COG0364  320 TETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPG 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 406 RTMETTPVKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEA 485
Cdd:COG0364  400 LGMRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEA 479

                        490
                 ....*....|....*
gi 518998921 486 ADELLQRDGFFWWPI 500
Cdd:COG0364  480 ADALLARDGRSWREP 494
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 10-500 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 846.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  10 LIQTNTPATLVLlFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETF---GMPQEKIGK 86
Cdd:PRK05722   3 LPRTAEPCDLVI-FGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFartPFDEEVWER 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  87 FIRHFYFQSHDVTDENSYRELKGLADELDEKYAANGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWDL 166
Cdd:PRK05722  82 FLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 167 SSAVELNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALR 246
Cdd:PRK05722 162 ASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 247 DMVQNHMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVHKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSNT 326
Cdd:PRK05722 242 DMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTT 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 327 ETFVAGKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSGR 406
Cdd:PRK05722 322 ETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGE 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 407 TMETTPVKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEAA 486
Cdd:PRK05722 402 GMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAA 481

                        490
                 ....*....|....
gi 518998921 487 DELLQRDGFFWWPI 500
Cdd:PRK05722 482 DALLARDGRSWREP 495
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 16-500 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 701.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   16 PATLVLLFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETF--GMPQEKIGKFIRHFYF 93
Cdd:TIGR00871   1 DPCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFetDEIDEQWDEFAQRLSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   94 QSHDVTDENSYRELKGLADELDEKYAANGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWDLSSAVELN 173
Cdd:TIGR00871  81 VSGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  174 ERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQNHM 253
Cdd:TIGR00871 161 KALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  254 LQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDvhKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSNTETFVAGK 333
Cdd:TIGR00871 241 LQLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALK 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  334 LMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRNGSSLNP-NLLVIHIQPEEGITLHLNVKKSGRTMETTP 412
Cdd:TIGR00871 319 LEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETRP 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  413 VKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEK-ADFPNYAAGTFGPEAADELLQ 491
Cdd:TIGR00871 399 VKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKgPSPPNYPAGSWGPKEADELIR 478


                  ....*....
gi 518998921  492 RDGFFWWPI 500
Cdd:TIGR00871 479 KDGRSWRKP 487
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
15-499 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 647.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  15 TPATLVLlFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETFGMP---QEKIGKFIRHF 91
Cdd:PRK12853   7 PPCTLVI-FGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGADgfdDAVWDRLAARL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  92 YFQSHDVTDENSYRELKgladeldEKYAANGNRIFYLAMSPEFFGTVAESLKEYGFTDtkGFKRLVIEKPFGWDLSSAVE 171
Cdd:PRK12853  86 SYVQGDVTDPADYARLA-------EALGPGGNPVFYLAVPPSLFAPVVENLGAAGLLP--EGRRVVLEKPFGHDLASARA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 172 LNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQN 251
Cdd:PRK12853 157 LNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQN 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 252 HMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVHKyfVRGQYGRGIIGGKEVPAYREEPMVDPNSNTETFVA 331
Cdd:PRK12853 237 HLLQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDVHT--VRGQYTAGTVGGEPVPGYREEPGVDPDSRTETFVA 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 332 GKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMnLYYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSGRTMETT 411
Cdd:PRK12853 315 LKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPH-ALFRGTGVEPPNRLVIRLQPDEGISLELNVKRPGPGMRLR 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 412 PVKLNFSNKnvDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEAADELLQ 491
Cdd:PRK12853 394 PVELDADYA--DDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLA 471


                 ....*...
gi 518998921 492 RDGFFWWP 499
Cdd:PRK12853 472 RDGRGWRE 479
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
202-498 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 528.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  202 VIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQNHMLQIVSLLAMEPPIRLTTDEIRSEKVKVL 281
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  282 RALHPIEKKDVHKYFVRGQYGRGIIGGKEVPAYREEPMVDPNSNTETFVAGKLMIDNFRWAGVPFYIRTGKRMQAKTLKI 361
Cdd:pfam02781  82 RSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  362 VVQFKDIPMNLyYRNGSSLNPNLLVIHIQPEEGITLHLNVKKSGRTMETTPVKLNFSNKNVDGINTPEAYEKLLYDILRG 441
Cdd:pfam02781 162 RIQFKDVPHNL-FRDPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 518998921  442 DATNFTHWDEVAYSWNFVDPISEAWAEEKadFPNYAAGTFGPEAADELLQRDGFFWW 498
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWDEEK--PPPYPAGSWGPKAADELLARDGRKWR 295
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 16-494 2.25e-166

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 479.15  E-value: 2.25e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  16 PATLVLLFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETFGMP---QEKIGKFIRHFY 92
Cdd:PRK12854  10 PPTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEFGARkldDGEWARFAKRLR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  93 FQSHDVTDENSyRELKGLADELDEKYAANGNRIFYLAMSPEFFGTVAESLKEYGFTDTKgfkRLVIEKPFGWDLSSAVEL 172
Cdd:PRK12854  90 YVPGGFLSAGP-GALAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEAGLAEGS---RVVMEKPFGTDLASAEAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 173 NERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQNH 252
Cdd:PRK12854 166 NAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTH 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 253 MLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVhkyfVRGQYGrgiiggkevpAYREEPMVDPNSNTETFVAG 332
Cdd:PRK12854 246 LFQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEV----VRGQYS----------GYRDEPGVAPDSTTETFVAL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 333 KLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLyYRNGS--SLNPNLLVIHIQPEEGITLHLNVKKSGRTMET 410
Cdd:PRK12854 312 KVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSM-FPAGSvgAQGPDHLTFDLADNSKVSLSFYGKRPGPGMRL 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 411 TPVKLNFSNKNVDGINTP-EAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKAdfpnYAAGTFGPEAADEL 489
Cdd:PRK12854 391 DKLSLQFSLKDTGPKGDVlEAYERLILDALRGDHTLFTTADGIESLWEVSQPLLEDPPPVKP----YAPGSWGPNAIHQL 466


                 ....*
gi 518998921 490 LQRDG 494
Cdd:PRK12854 467 AAPDA 471
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 20-495 3.44e-152

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 445.35  E-value: 3.44e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  20 VLLFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQyrNWVKDSVETFGM----PQEKIGKFIRHFYFQS 95
Cdd:PTZ00309  57 IIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVE--RWKKETLARFFKrlddRECHLEQFLKHISYIS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  96 HDVTDENSYRELKGLADELDEKYA---ANGNRIFYLAMSPEFFGTVAESLKEYGFTDTkGFKRLVIEKPFGWDLSSAVEL 172
Cdd:PTZ00309 135 GSYDEDEDFKRLNKLIERMEEAFQgpeKGGNRLFYLALPPSVFASVCEGIHRGCMSKN-GWVRVIVEKPFGRDLESSEEL 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 173 NERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQNH 252
Cdd:PTZ00309 214 SNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNH 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 253 MLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVhkyfVRGQYgRGIIGGKeVPAYREEPMVDPNSNTETFVAG 332
Cdd:PTZ00309 294 LLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEEC----VLGQY-TASADGS-IPGYLEDEGVPKDSTTPTFAAA 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 333 KLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYrnGSSLNPNLLVIHIQPEEGITLHLNVKKSGRTMETTP 412
Cdd:PTZ00309 368 VLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPS--GDDTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQ 445

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 413 VKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEAADELLQR 492
Cdd:PTZ00309 446 TELDLTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKK 525


                 ...
gi 518998921 493 DGF 495
Cdd:PTZ00309 526 NGF 528
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 20-495 1.89e-127

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 380.22  E-value: 1.89e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  20 VLLFGATGDLAKRKLYPSLYNLYEKGIL-SEQFAVIGIARRRLT----HEQYRNWVKDSVETfgmPQEKIGKFIRHFYFQ 94
Cdd:PLN02539  20 IIVLGASGDLAKKKTFPALFNLYRQGFLpPDEVHIFGYARSKITdeelRDRIRGYLKDEKNA---PAEAVSKFLQLIKYV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  95 SHDVTDENSYREL-KGLADELDEKYAANG--NRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWDLSSAVE 171
Cdd:PLN02539  97 SGAYDSEEGFRRLdKEISEHEISKNSAEGssRRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKDLESAEE 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 172 LNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQN 251
Cdd:PLN02539 177 LSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQN 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 252 HMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVhkyfVRGQYgrgiiggkevPAYREEPMVDPNSNTETFVA 331
Cdd:PLN02539 257 HLLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEV----VLGQY----------EGYRDDPTVPDDSNTPTFAS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 332 GKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYyrNGSSLNPNLLVIHIQPEEGITLHLNVKKSGRTMETT 411
Cdd:PLN02539 323 VVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIF--KCQKQGRNEFVIRLQPSEAMYMKLTVKQPGLEMSTV 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 412 PVKLNFS-NKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAWAEEKADFPNYAAGTFGPEAADELL 490
Cdd:PLN02539 401 QSELDLSyGQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGPAEADELL 480


                 ....*
gi 518998921 491 QRDGF 495
Cdd:PLN02539 481 EKAGY 485
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 20-497 6.92e-125

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 376.66  E-value: 6.92e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  20 VLLFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDS----VETFGMPQEKIGKFIRHFYFQS 95
Cdd:PLN02640  91 ITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTltcrIDQRENCGDKMDQFLKRCFYHS 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  96 HDVTDENSYRELKglaDELDEKYAAN-GNRIFYLAMSPEFFGTVAE--SLKEygfTDTKGFKRLVIEKPFGWDLSSAVEL 172
Cdd:PLN02640 171 GQYDSEEDFAELN---KKLKEKEAGKlSNRLFYLSIPPNIFVDVVRcaSLRA---SSENGWTRVIVEKPFGRDSESSGEL 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 173 NERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQNH 252
Cdd:PLN02640 245 TRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNH 324

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 253 MLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVhkyfVRGQYGRGIIGGKEVPAYREEPMVDPNSNTETFVAG 332
Cdd:PLN02640 325 LLQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDV----IVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFAAA 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 333 KLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRN-GSSLN--PNLLVIHIQPEEGITLHLNVKKSGRTME 409
Cdd:PLN02640 401 ALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYKRNfGTDLDkaTNELVLRVQPDEAIYLKINNKVPGLGMR 480

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 410 TTPVKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAwAEEKADFPN-YAAGTFGPEAADE 488
Cdd:PLN02640 481 LDRSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKE-LEEKKIIPElYPYGSRGPVGAHY 559


                 ....*....
gi 518998921 489 LLQRDGFFW 497
Cdd:PLN02640 560 LAAKYNVRW 568
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 20-497 2.26e-121

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 368.53  E-value: 2.26e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  20 VLLFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVK-------DSVETFGmpqEKIGKFIRHFY 92
Cdd:PLN02333 120 ITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSktltcriDKRENCG---EKMEEFLKRCF 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  93 FQSHDVTDENSYRELKglaDELDEKYAAN-GNRIFYLAMSPEFFgTVAESLKEYGFTDTKGFKRLVIEKPFGWDLSSAVE 171
Cdd:PLN02333 197 YHSGQYDSQEHFAELD---KKLKEHEGGRvSNRLFYLSIPPNIF-VDAVKCASSSASSVNGWTRVIVEKPFGRDSESSAA 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 172 LNERIRSAFSEKEIYRIDHYLGKEMVQNIEVIRFANAIFEPLWNNRYISNIQITSGETLGVEERGRYYEKNGALRDMVQN 251
Cdd:PLN02333 273 LTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQN 352

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 252 HMLQIVSLLAMEPPIRLTTDEIRSEKVKVLRALHPIEKKDVhkyfVRGQYGRGIIGGKEVPAYREEPMVDPNSNTETFVA 331
Cdd:PLN02333 353 HLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDV----VIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAA 428

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 332 GKLMIDNFRWAGVPFYIRTGKRMQAKTLKIVVQFKDIPMNLYYRN-GSSLN--PNLLVIHIQPEEGITLHLNVKKSGRTM 408
Cdd:PLN02333 429 AALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYNRNfGTDLDqaTNELVIRVQPDEAIYLKINNKVPGLGM 508

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921 409 ETTPVKLNFSNKNVDGINTPEAYEKLLYDILRGDATNFTHWDEVAYSWNFVDPISEAwAEEKADFPN-YAAGTFGPEAAD 487
Cdd:PLN02333 509 RLDRSNLNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKE-LEEKKIIPEyYPYGSRGPVGAH 587

                        490
                 ....*....|
gi 518998921 488 ELLQRDGFFW 497
Cdd:PLN02333 588 YLAARYKVRW 597
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
22-199 6.41e-89

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 270.06  E-value: 6.41e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921   22 LFGATGDLAKRKLYPSLYNLYEKGILSEQFAVIGIARRRLTHEQYRNWVKDSVETFG-MPQEKIGKFIRHFYFQSHDVTD 100
Cdd:pfam00479   2 IFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFKeLDEEKWDRFLERLHYVSGDFDD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998921  101 ENSYRELKGLADELDEKyaANGNRIFYLAMSPEFFGTVAESLKEYGFTDTKGFKRLVIEKPFGWDLSSAVELNERIRSAF 180
Cdd:pfam00479  82 PESYEKLKERLEEHEDE--TRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARELNDQLAKVF 159

                         170
                  ....*....|....*....
gi 518998921  181 SEKEIYRIDHYLGKEMVQN 199
Cdd:pfam00479 160 KEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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