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Conserved domains on  [gi|520785863|ref|WP_020289900|]
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TerC family protein [Pseudomonas sp. CFII64]

Protein Classification

TerC family protein( domain architecture ID 11436733)

TerC family inner membrane protein similar to Escherichia coli YoaE and YegH, which contain a TerC domain, tandem repeats of the cystathionine beta-synthase (CBS pair) domain, and a transporter-associated domain

Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 248-516 1.27e-70

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


:

Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 231.93  E-value: 1.27e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 248 RTAHAVMRLLGGRKLDADEV--GEEIADMLEGEQTAAVFDRRERVMISGVLQLAERPIRAVMTPRAEVDHIDLADDAEKI 325
Cdd:COG1253  159 GSTNLLLRLLGIEPAEEEPAvtEEELRALVEESEESGVIEEEEREMIENVFEFGDRTVREVMTPRTDVVALDLDDTLEEA 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 326 NLKLMHSSYSRLPLIRDGrIDEPLGFVHKKELFKELLVGNQPNLENLARKAINLLDSFTILNALEQMRKESTHIAFVVNE 405
Cdd:COG1253  239 LELILESGHSRIPVYEGD-LDDIVGVVHVKDLLRALLEGEPFDLRDLLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDE 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 406 FGDFIGLLTMTDILESIAGQLPDASEIEGPDIVAQ-EGGFLVSGALNLNHVRERTGFQARATEDYQTVAGLVMSLLDRLP 484
Cdd:COG1253  318 YGGTAGLVTLEDILEEIVGEIRDEYDEEEPEIVKLdDGSYLVDGRLPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIP 397

                        250       260       270
                 ....*....|....*....|....*....|..
gi 520785863 485 RTGDKLDWEGWNMTVVGVEERRVTRVALRKSE 516
Cdd:COG1253  398 EVGETVEVDGLRFEVLDMDGRRIDKVLVTRLP 429
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-237 3.66e-69

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


:

Pssm-ID: 440622  Cd Length: 225  Bit Score: 221.08  E-value: 3.66e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863   1 MEWIVD-PTAWLGLLTLIVLELVLGIDNLVFIAILADKLPPEQRDKARVIGLSLALIMRLGLLASISWMVTLTQplfevf 79
Cdd:COG0861    1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSFPW------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863  80 ehsfsgrdlIMLFGGVFLLFKATMELHERLEGHVSERTSNSTYAKFWPIVAQIVVLDAVFSLDAVITAVGMVEHLAVMMI 159
Cdd:COG0861   75 ---------ILYLGGLFLLWTAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520785863 160 AVMISIGLMIIASKPLTRFVNAHPTVIMLCLGFLMMIGFSLTAEGLGFHIPKGYLYAAIGFSILIevFNQVARMRRKR 237
Cdd:COG0861  146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVLA--LGILASLLKRR 221
 
Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 248-516 1.27e-70

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 231.93  E-value: 1.27e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 248 RTAHAVMRLLGGRKLDADEV--GEEIADMLEGEQTAAVFDRRERVMISGVLQLAERPIRAVMTPRAEVDHIDLADDAEKI 325
Cdd:COG1253  159 GSTNLLLRLLGIEPAEEEPAvtEEELRALVEESEESGVIEEEEREMIENVFEFGDRTVREVMTPRTDVVALDLDDTLEEA 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 326 NLKLMHSSYSRLPLIRDGrIDEPLGFVHKKELFKELLVGNQPNLENLARKAINLLDSFTILNALEQMRKESTHIAFVVNE 405
Cdd:COG1253  239 LELILESGHSRIPVYEGD-LDDIVGVVHVKDLLRALLEGEPFDLRDLLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDE 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 406 FGDFIGLLTMTDILESIAGQLPDASEIEGPDIVAQ-EGGFLVSGALNLNHVRERTGFQARATEDYQTVAGLVMSLLDRLP 484
Cdd:COG1253  318 YGGTAGLVTLEDILEEIVGEIRDEYDEEEPEIVKLdDGSYLVDGRLPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIP 397

                        250       260       270
                 ....*....|....*....|....*....|..
gi 520785863 485 RTGDKLDWEGWNMTVVGVEERRVTRVALRKSE 516
Cdd:COG1253  398 EVGETVEVDGLRFEVLDMDGRRIDKVLVTRLP 429
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-237 3.66e-69

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 221.08  E-value: 3.66e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863   1 MEWIVD-PTAWLGLLTLIVLELVLGIDNLVFIAILADKLPPEQRDKARVIGLSLALIMRLGLLASISWMVTLTQplfevf 79
Cdd:COG0861    1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSFPW------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863  80 ehsfsgrdlIMLFGGVFLLFKATMELHERLEGHVSERTSNSTYAKFWPIVAQIVVLDAVFSLDAVITAVGMVEHLAVMMI 159
Cdd:COG0861   75 ---------ILYLGGLFLLWTAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520785863 160 AVMISIGLMIIASKPLTRFVNAHPTVIMLCLGFLMMIGFSLTAEGLGFHIPKGYLYAAIGFSILIevFNQVARMRRKR 237
Cdd:COG0861  146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVLA--LGILASLLKRR 221
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
 14-204 6.13e-46

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 158.40  E-value: 6.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863   14 LTLIVLELVLGIDNLVFIAILADKLPPEQRDKARVIGLSLALIMRLGLLASISWMVTLtqplfevfehsfsgRDLIMLFG 93
Cdd:pfam03741   1 FTLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLEL--------------FDWLLLIG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863   94 GVFLLFKATMELHE-RLEGHVSERTSNSTYAKFWPIVAQIVVLDAVFSLDAVITAVGMVEHLAVMMIAVMISIGLMIIAS 172
Cdd:pfam03741  67 GLFLLYTAIKLLRDlRKLVREEDKKLPVTSSSLWLAVIQIELADLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRFLS 146

                         170       180       190
                  ....*....|....*....|....*....|..
gi 520785863  173 KPLTRFVNAHPTVIMLCLGFLMMIGFSLTAEG 204
Cdd:pfam03741 147 FLLAKLIERFPYLKYLAAAILGFIGVKLLLEG 178
CBS_pair_CorC_HlyC_assoc cd04590
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ...
 302-420 1.16e-32

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341366 [Multi-domain]  Cd Length: 119  Bit Score: 120.68  E-value: 1.16e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 302 PIRAVMTPRAEVDHIDLADDAEKINLKLMHSSYSRLPLIRDGrIDEPLGFVHKKELFKELLVGNQP-NLENLARKAINLL 380
Cdd:cd04590    1 TVREVMTPRTDVVALDADATLEELLELILESGYSRFPVYEGD-LDNIIGVLHVKDLLAALLEGREKlDLRALLRPPLFVP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 520785863 381 DSFTILNALEQMRKESTHIAFVVNEFGDFIGLLTMTDILE 420
Cdd:cd04590   80 ETTPLDDLLEEFRKERSHMAIVVDEYGGTAGIVTLEDILE 119
PRK15094 PRK15094
magnesium/cobalt transporter CorC;
255-516 6.99e-21

magnesium/cobalt transporter CorC;


Pssm-ID: 185050 [Multi-domain]  Cd Length: 292  Bit Score: 92.95  E-value: 6.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 255 RLLGGRKLDADEVGEEIADmleGEQTAaVFDRRERVMISGVLQLAERPIRAVMTPRAEVDHIDLADDAEKINLKLMHSSY 334
Cdd:PRK15094  25 QLFHGEPKNRDELLALIRD---SEQND-LIDEDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAH 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 335 SRLPLIRDGRiDEPLGFVHKKELFKELLVGNQP-NLENLARKAINLLDSFTILNALEQMRKESTHIAFVVNEFGDFIGLL 413
Cdd:PRK15094 101 SRFPVISEDK-DHIEGILMAKDLLPFMRSDAEAfSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 414 TMTDILESIAGQLPDA-SEIEGPDIVAQEGGFLVSGAL----NLNHVRErTGFqarATEDYQTVAGLVMSLLDRLPRTGD 488
Cdd:PRK15094 180 TIEDILELIVGEIEDEyDEEDDIDFRQLSRHTWTVRALasieDFNEAFG-THF---SDEEVDTIGGLVMQAFGHLPARGE 255

                        250       260
                 ....*....|....*....|....*...
gi 520785863 489 KLDWEGWNMTVVGVEERRVTRVALRKSE 516
Cdd:PRK15094 256 TIDIDGYQFKVAMADSRRIIQVHVKIPD 283
CorC_HlyC smart01091
Transporter associated domain; This small domain is found in a family of proteins with the ...
 441-514 1.28e-16

Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 215020 [Multi-domain]  Cd Length: 78  Bit Score: 74.40  E-value: 1.28e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 520785863   441 EGGFLVSGALNLNHVRERTGFQArATEDYQTVAGLVMSLLDRLPRTGDKLDWEGWNMTVVGVEERRVTRVALRK 514
Cdd:smart01091   5 DGSYLVDGRTPIDDLNELLGLDL-PEEEYDTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTR 77
CorC_HlyC pfam03471
Transporter associated domain; This small domain is found in a family of proteins with the ...
 437-516 1.49e-14

Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 460935 [Multi-domain]  Cd Length: 81  Bit Score: 68.73  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863  437 IVAQEGGFLVSGALNLNHVRERTGFqARATEDYQTVAGLVMSLLDRLPRTGDKL--DWEGWNMTVVGVEERRVTRVALRK 514
Cdd:pfam03471   1 EKLDDGSYLVDGRAPLDDLNELLGL-ELPEEDYDTLGGLVLERLGRIPKVGDKVevELGGLRFTVLEMDGRRIKKVRITK 79


                  ..
gi 520785863  515 SE 516
Cdd:pfam03471  80 LE 81
 
Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 248-516 1.27e-70

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 231.93  E-value: 1.27e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 248 RTAHAVMRLLGGRKLDADEV--GEEIADMLEGEQTAAVFDRRERVMISGVLQLAERPIRAVMTPRAEVDHIDLADDAEKI 325
Cdd:COG1253  159 GSTNLLLRLLGIEPAEEEPAvtEEELRALVEESEESGVIEEEEREMIENVFEFGDRTVREVMTPRTDVVALDLDDTLEEA 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 326 NLKLMHSSYSRLPLIRDGrIDEPLGFVHKKELFKELLVGNQPNLENLARKAINLLDSFTILNALEQMRKESTHIAFVVNE 405
Cdd:COG1253  239 LELILESGHSRIPVYEGD-LDDIVGVVHVKDLLRALLEGEPFDLRDLLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDE 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 406 FGDFIGLLTMTDILESIAGQLPDASEIEGPDIVAQ-EGGFLVSGALNLNHVRERTGFQARATEDYQTVAGLVMSLLDRLP 484
Cdd:COG1253  318 YGGTAGLVTLEDILEEIVGEIRDEYDEEEPEIVKLdDGSYLVDGRLPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIP 397

                        250       260       270
                 ....*....|....*....|....*....|..
gi 520785863 485 RTGDKLDWEGWNMTVVGVEERRVTRVALRKSE 516
Cdd:COG1253  398 EVGETVEVDGLRFEVLDMDGRRIDKVLVTRLP 429
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-237 3.66e-69

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 221.08  E-value: 3.66e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863   1 MEWIVD-PTAWLGLLTLIVLELVLGIDNLVFIAILADKLPPEQRDKARVIGLSLALIMRLGLLASISWMVTLTQplfevf 79
Cdd:COG0861    1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSFPW------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863  80 ehsfsgrdlIMLFGGVFLLFKATMELHERLEGHVSERTSNSTYAKFWPIVAQIVVLDAVFSLDAVITAVGMVEHLAVMMI 159
Cdd:COG0861   75 ---------ILYLGGLFLLWTAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520785863 160 AVMISIGLMIIASKPLTRFVNAHPTVIMLCLGFLMMIGFSLTAEGLGFHIPKGYLYAAIGFSILIevFNQVARMRRKR 237
Cdd:COG0861  146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVLA--LGILASLLKRR 221
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
 14-204 6.13e-46

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 158.40  E-value: 6.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863   14 LTLIVLELVLGIDNLVFIAILADKLPPEQRDKARVIGLSLALIMRLGLLASISWMVTLtqplfevfehsfsgRDLIMLFG 93
Cdd:pfam03741   1 FTLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLEL--------------FDWLLLIG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863   94 GVFLLFKATMELHE-RLEGHVSERTSNSTYAKFWPIVAQIVVLDAVFSLDAVITAVGMVEHLAVMMIAVMISIGLMIIAS 172
Cdd:pfam03741  67 GLFLLYTAIKLLRDlRKLVREEDKKLPVTSSSLWLAVIQIELADLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRFLS 146

                         170       180       190
                  ....*....|....*....|....*....|..
gi 520785863  173 KPLTRFVNAHPTVIMLCLGFLMMIGFSLTAEG 204
Cdd:pfam03741 147 FLLAKLIERFPYLKYLAAAILGFIGVKLLLEG 178
CorB COG4536
Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion ...
 250-514 4.81e-44

Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion transport and metabolism];


Pssm-ID: 443602 [Multi-domain]  Cd Length: 420  Bit Score: 160.63  E-value: 4.81e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 250 AHAVMRLLGGRKLDADEVG---EEIADMLEGEQTAAVFDRRERVMISGVLQLAERPIRAVMTPRAEVDHIDLADDAEKIN 326
Cdd:COG4536  150 VRGLLRLFGVKPDADASDLlseEELRTVVDLGEAGGVIPKEHRDMLLNILDLEDVTVEDIMVPRNEIEGIDLDDPWEEIL 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 327 LKLMHSSYSRLPLIRDgRIDEPLGFVHKKELFKELLVG--NQPNLENLARKAINLLDSFTILNALEQMRKESTHIAFVVN 404
Cdd:COG4536  230 KQLLTSPHTRLPVYRG-DIDNIVGVLHVRDLLRALRKGdlSKEDLRKIAREPYFIPETTPLSTQLQNFQKRKRRFALVVD 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 405 EFGDFIGLLTMTDILESIAGQLPDASEIEGPDIVAQE-GGFLVSGALNLNHVRERTGFQArATEDYQTVAGLVMSLLDRL 483
Cdd:COG4536  309 EYGDVQGLVTLEDILEEIVGEITDEHDPDAEEIRPQEdGSYLVDGSATIRDLNRALDWNL-PDDGAKTLNGLIIEELEDI 387

                        250       260       270
                 ....*....|....*....|....*....|.
gi 520785863 484 PRTGDKLDWEGWNMTVVGVEERRVTRVALRK 514
Cdd:COG4536  388 PEAGQSFTIHGYRFEILQVQDNRIKTVRIRP 418
CBS_pair_CorC_HlyC_assoc cd04590
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ...
 302-420 1.16e-32

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341366 [Multi-domain]  Cd Length: 119  Bit Score: 120.68  E-value: 1.16e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 302 PIRAVMTPRAEVDHIDLADDAEKINLKLMHSSYSRLPLIRDGrIDEPLGFVHKKELFKELLVGNQP-NLENLARKAINLL 380
Cdd:cd04590    1 TVREVMTPRTDVVALDADATLEELLELILESGYSRFPVYEGD-LDNIIGVLHVKDLLAALLEGREKlDLRALLRPPLFVP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 520785863 381 DSFTILNALEQMRKESTHIAFVVNEFGDFIGLLTMTDILE 420
Cdd:cd04590   80 ETTPLDDLLEEFRKERSHMAIVVDEYGGTAGIVTLEDILE 119
PRK15094 PRK15094
magnesium/cobalt transporter CorC;
255-516 6.99e-21

magnesium/cobalt transporter CorC;


Pssm-ID: 185050 [Multi-domain]  Cd Length: 292  Bit Score: 92.95  E-value: 6.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 255 RLLGGRKLDADEVGEEIADmleGEQTAaVFDRRERVMISGVLQLAERPIRAVMTPRAEVDHIDLADDAEKINLKLMHSSY 334
Cdd:PRK15094  25 QLFHGEPKNRDELLALIRD---SEQND-LIDEDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAH 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 335 SRLPLIRDGRiDEPLGFVHKKELFKELLVGNQP-NLENLARKAINLLDSFTILNALEQMRKESTHIAFVVNEFGDFIGLL 413
Cdd:PRK15094 101 SRFPVISEDK-DHIEGILMAKDLLPFMRSDAEAfSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 414 TMTDILESIAGQLPDA-SEIEGPDIVAQEGGFLVSGAL----NLNHVRErTGFqarATEDYQTVAGLVMSLLDRLPRTGD 488
Cdd:PRK15094 180 TIEDILELIVGEIEDEyDEEDDIDFRQLSRHTWTVRALasieDFNEAFG-THF---SDEEVDTIGGLVMQAFGHLPARGE 255

                        250       260
                 ....*....|....*....|....*...
gi 520785863 489 KLDWEGWNMTVVGVEERRVTRVALRKSE 516
Cdd:PRK15094 256 TIDIDGYQFKVAMADSRRIIQVHVKIPD 283
CorC_HlyC smart01091
Transporter associated domain; This small domain is found in a family of proteins with the ...
 441-514 1.28e-16

Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 215020 [Multi-domain]  Cd Length: 78  Bit Score: 74.40  E-value: 1.28e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 520785863   441 EGGFLVSGALNLNHVRERTGFQArATEDYQTVAGLVMSLLDRLPRTGDKLDWEGWNMTVVGVEERRVTRVALRK 514
Cdd:smart01091   5 DGSYLVDGRTPIDDLNELLGLDL-PEEEYDTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTR 77
PRK11573 PRK11573
hypothetical protein; Provisional
 286-510 4.18e-16

hypothetical protein; Provisional


Pssm-ID: 236933 [Multi-domain]  Cd Length: 413  Bit Score: 80.18  E-value: 4.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 286 RRERVMISGVLQLAERPIRAVMTPRAEVDHIDLADDAEKINLKLMHSSYSRLPLIRDGrIDEPLGFVHKKELFKELLVGN 365
Cdd:PRK11573 172 RRNQDMLLSVLDLEKVTVDDIMVPRNEIVGIDINDDWKSILRQLTHSPHGRIVLYRDS-LDDAISMLRVREAYRLMTEKK 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 366 QPNLENLARKA--INLLDSFTILNA-LEQMRKESTHIAFVVNEFGDFIGLLTMTDILESIAGQL-----PDASEIEGPDi 437
Cdd:PRK11573 251 EFTKENMLRAAdeIYFVPEGTPLSTqLVKFQRNKKKVGLVVDEYGDIQGLVTVEDILEEIVGDFttsmsPTLAEEVTPQ- 329

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 520785863 438 vaQEGGFLVSGALNLNHVRERTGFQARAtEDYQTVAGLVMSLLDRLPRTGDKLDWEGWNMTVVGVEERRVTRV 510
Cdd:PRK11573 330 --NDGSVIIDGTANVREINKAFNWHLPE-DDARTVNGVILEALEEIPVAGTRVRIGEYDIDILDVQDNMIKQV 399
CorC_HlyC pfam03471
Transporter associated domain; This small domain is found in a family of proteins with the ...
 437-516 1.49e-14

Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 460935 [Multi-domain]  Cd Length: 81  Bit Score: 68.73  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863  437 IVAQEGGFLVSGALNLNHVRERTGFqARATEDYQTVAGLVMSLLDRLPRTGDKL--DWEGWNMTVVGVEERRVTRVALRK 514
Cdd:pfam03471   1 EKLDDGSYLVDGRAPLDDLNELLGL-ELPEEDYDTLGGLVLERLGRIPKVGDKVevELGGLRFTVLEMDGRRIKKVRITK 79


                  ..
gi 520785863  515 SE 516
Cdd:pfam03471  80 LE 81
COG3448 COG3448
CBS-domain-containing membrane protein [Signal transduction mechanisms];
303-429 3.82e-04

CBS-domain-containing membrane protein [Signal transduction mechanisms];


Pssm-ID: 442671 [Multi-domain]  Cd Length: 136  Bit Score: 40.62  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 303 IRAVMTPraEVDHIDLADDAEKINLKLMHSSYSRLPLIRDGRidEPLGFVHKKELFKELLVGNQPNLENLA--------- 373
Cdd:COG3448    4 VRDIMTR--DVVTVSPDTTLREALELMREHGIRGLPVVDEDG--RLVGIVTERDLLRALLPDRLDELEERLldlpvedvm 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 520785863 374 -RKAINLLDSFTILNALEQMRKESTHIAFVVNEFGDFIGLLTMTDILESIAGQLPDA 429
Cdd:COG3448   80 tRPVVTVTPDTPLEEAAELMLEHGIHRLPVVDDDGRLVGIVTRTDLLRALARLLEEE 136
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 384-424 4.59e-04

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 38.35  E-value: 4.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 520785863  384 TILNALEQMRKESTHIAFVVNEFGDFIGLLTMTDILESIAG 424
Cdd:pfam00571  17 TLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
CBS_pair_SF cd02205
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...
 327-419 1.02e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341358 [Multi-domain]  Cd Length: 113  Bit Score: 38.76  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 327 LKLMHSS-YSRLPLIRDGriDEPLGFVHKKELFKELLVGNQPNLENLA----RKAINLLDSFTILNALEQMRKESTHIAF 401
Cdd:cd02205   17 LELMAENgIGALPVVDDD--GKLVGIVTERDILRALVEGGLALDTPVAevmtPDVITVSPDTDLEEALELMLEHGIRRLP 94

                         90
                 ....*....|....*...
gi 520785863 402 VVNEFGDFIGLLTMTDIL 419
Cdd:cd02205   95 VVDDDGKLVGIVTRRDIL 112
COG2524 COG2524
Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];
230-422 1.63e-03

Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];


Pssm-ID: 442013 [Multi-domain]  Cd Length: 206  Bit Score: 39.87  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 230 VARMRRKRSLHGVRPMRERTAHAVMRLLGGRKLDADEVGEEIADMLEGEQTAAVFDRRERVMISGVLQLAERPIRAVMTP 309
Cdd:COG2524   15 LLAVVLAALLLLAALVLALTAAAAATVLLLAAAAAAAGAGGLGLLLLLLLIVLQAAAVRVVAEKELGLVLKMKVKDIMTK 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520785863 310 RAEVdhIDLADDAEKINLKLMHSSYSRLPLIRDGRidePLGFVHKKELFKELLVGNQPNLENLA----RKAINLLDSFTI 385
Cdd:COG2524   95 DVIT--VSPDTTLEEALELMLEKGISGLPVVDDGK---LVGIITERDLLKALAEGRDLLDAPVSdimtRDVVTVSEDDSL 169

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 520785863 386 LNALEQMRKESTHIAFVVNEFGDFIGLLTMTDILESI 422
Cdd:COG2524  170 EEALRLMLEHGIGRLPVVDDDGKLVGIITRTDILRAL 206
CBS_pair_SF cd02205
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...
 374-425 4.94e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341358 [Multi-domain]  Cd Length: 113  Bit Score: 36.84  E-value: 4.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 520785863 374 RKAINLLDSFTILNALEQMRKESTHIAFVVNEFGDFIGLLTMTDILESIAGQ 425
Cdd:cd02205    2 RDVVTVDPDTTVREALELMAENGIGALPVVDDDGKLVGIVTERDILRALVEG 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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