NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|520909686|ref|WP_020329515|]
View 

MULTISPECIES: inorganic diphosphatase [Vibrio]

Protein Classification

inorganic diphosphatase( domain architecture ID 10792152)

inorganic diphosphatase catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions

EC:  3.6.1.1
Gene Ontology:  GO:0046872|GO:0004427|GO:0006796
PubMed:  9201917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK01250 PRK01250
inorganic diphosphatase;
1-176 1.68e-131

inorganic diphosphatase;


:

Pssm-ID: 179262  Cd Length: 176  Bit Score: 364.96  E-value: 1.68e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   1 MSLNNVPAGKSLPDDIYVVIEIPANADPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPL 80
Cdd:PRK01250   1 MSLNKIPAGKDLPEDINVIIEIPANSDPIKYEVDKESGALFVDRFLYTAMFYPCNYGFIPHTLSLDGDPVDVLVVTPYPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  81 IPGSVIRCRPVGVLKMTDESGEDAKVVAVPHSKLSKEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAA 160
Cdd:PRK01250  81 VPGSVIRCRPVGVLKMEDESGEDAKIIAVPHDKLSPEYDHIKDVNDLPELLKAQIKHFFEHYKDLEKGKWVKVEGWGGAE 160
                        170
                 ....*....|....*.
gi 520909686 161 SARAEILTSYERAQQK 176
Cdd:PRK01250 161 EAKAEIVEAIERAKKK 176
 
Name Accession Description Interval E-value
PRK01250 PRK01250
inorganic diphosphatase;
1-176 1.68e-131

inorganic diphosphatase;


Pssm-ID: 179262  Cd Length: 176  Bit Score: 364.96  E-value: 1.68e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   1 MSLNNVPAGKSLPDDIYVVIEIPANADPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPL 80
Cdd:PRK01250   1 MSLNKIPAGKDLPEDINVIIEIPANSDPIKYEVDKESGALFVDRFLYTAMFYPCNYGFIPHTLSLDGDPVDVLVVTPYPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  81 IPGSVIRCRPVGVLKMTDESGEDAKVVAVPHSKLSKEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAA 160
Cdd:PRK01250  81 VPGSVIRCRPVGVLKMEDESGEDAKIIAVPHDKLSPEYDHIKDVNDLPELLKAQIKHFFEHYKDLEKGKWVKVEGWGGAE 160
                        170
                 ....*....|....*.
gi 520909686 161 SARAEILTSYERAQQK 176
Cdd:PRK01250 161 EAKAEIVEAIERAKKK 176
Ppa COG0221
Inorganic pyrophosphatase [Energy production and conversion];
1-176 8.11e-102

Inorganic pyrophosphatase [Energy production and conversion];


Pssm-ID: 439991  Cd Length: 174  Bit Score: 290.07  E-value: 8.11e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   1 MSLNNVPAGKSLPDDIYVVIEIPANADpIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPL 80
Cdd:COG0221    1 MNLHDIPPGKNAPEEVNVVIEIPKGSR-VKYEYDKETGALRVDRVLYTSMHYPANYGFIPQTLAEDGDPLDVLVLTPEPT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  81 IPGSVIRCRPVGVLKMTDESGEDAKVVAVPHSklSKEYDHIQDVNDLPELLKAQITHFFERYKELEsGKWVKVDGWEDAA 160
Cdd:COG0221   80 FPGCVIRARPIGVLKMEDEGGRDDKILAVPVD--DPRYDHIKDISDLPPHLLDEIEHFFEHYKDLE-GKWVKVEGWGGAE 156
                        170
                 ....*....|....*.
gi 520909686 161 SARAEILTSYERAQQK 176
Cdd:COG0221  157 EAKKEIEEAIERYKKK 172
pyrophosphatase cd00412
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two ...
14-171 3.42e-83

Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.


Pssm-ID: 238239  Cd Length: 155  Bit Score: 242.38  E-value: 3.42e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  14 DDIYVVIEIPANaDPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPLIPGSVIRCRPVGV 93
Cdd:cd00412    1 EVVNVVIEIPKG-SNAKYEIDKETGPIKVDRFLYSSMGYPWNYGFIPQTLEDDGDPLDVLVIGEEPLFPGSVIRVRPLGV 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520909686  94 LKMTDESGEDAKVVAVPHSKLskEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAASARAEILTSYE 171
Cdd:cd00412   80 LKMIDEGETDWKVIAVPVDDP--RYSHINDISDVPPHLLDEIKHFFEHYKDLEGKKEVKVAGWKDKEEALKIIKESIE 155
Pyrophosphatase pfam00719
Inorganic pyrophosphatase;
18-174 5.44e-83

Inorganic pyrophosphatase;


Pssm-ID: 459915  Cd Length: 154  Bit Score: 241.52  E-value: 5.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   18 VVIEIPANaDPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPLIPGSVIRCRPVGVLKMT 97
Cdd:pfam00719   1 VVIEIPKG-SNAKYEIDKETGALRLDRVLFTSMGYPANYGFIPQTLEDDGDPLDVLVLGSEPTFPGCVVRVRPIGVLAMI 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520909686   98 DESGEDAKVVAVPHSklSKEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAASARAEILTSYERAQ 174
Cdd:pfam00719  80 DEGETDDKIIAVPVD--DPRYDDINDISDLPGHLLDEIEHFFEHYKDLEGKKNVKVDGWKDAEEAEKIIEEAIERYK 154
 
Name Accession Description Interval E-value
PRK01250 PRK01250
inorganic diphosphatase;
1-176 1.68e-131

inorganic diphosphatase;


Pssm-ID: 179262  Cd Length: 176  Bit Score: 364.96  E-value: 1.68e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   1 MSLNNVPAGKSLPDDIYVVIEIPANADPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPL 80
Cdd:PRK01250   1 MSLNKIPAGKDLPEDINVIIEIPANSDPIKYEVDKESGALFVDRFLYTAMFYPCNYGFIPHTLSLDGDPVDVLVVTPYPL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  81 IPGSVIRCRPVGVLKMTDESGEDAKVVAVPHSKLSKEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAA 160
Cdd:PRK01250  81 VPGSVIRCRPVGVLKMEDESGEDAKIIAVPHDKLSPEYDHIKDVNDLPELLKAQIKHFFEHYKDLEKGKWVKVEGWGGAE 160
                        170
                 ....*....|....*.
gi 520909686 161 SARAEILTSYERAQQK 176
Cdd:PRK01250 161 EAKAEIVEAIERAKKK 176
Ppa COG0221
Inorganic pyrophosphatase [Energy production and conversion];
1-176 8.11e-102

Inorganic pyrophosphatase [Energy production and conversion];


Pssm-ID: 439991  Cd Length: 174  Bit Score: 290.07  E-value: 8.11e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   1 MSLNNVPAGKSLPDDIYVVIEIPANADpIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPL 80
Cdd:COG0221    1 MNLHDIPPGKNAPEEVNVVIEIPKGSR-VKYEYDKETGALRVDRVLYTSMHYPANYGFIPQTLAEDGDPLDVLVLTPEPT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  81 IPGSVIRCRPVGVLKMTDESGEDAKVVAVPHSklSKEYDHIQDVNDLPELLKAQITHFFERYKELEsGKWVKVDGWEDAA 160
Cdd:COG0221   80 FPGCVIRARPIGVLKMEDEGGRDDKILAVPVD--DPRYDHIKDISDLPPHLLDEIEHFFEHYKDLE-GKWVKVEGWGGAE 156
                        170
                 ....*....|....*.
gi 520909686 161 SARAEILTSYERAQQK 176
Cdd:COG0221  157 EAKKEIEEAIERYKKK 172
pyrophosphatase cd00412
Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two ...
14-171 3.42e-83

Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.


Pssm-ID: 238239  Cd Length: 155  Bit Score: 242.38  E-value: 3.42e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  14 DDIYVVIEIPANaDPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPLIPGSVIRCRPVGV 93
Cdd:cd00412    1 EVVNVVIEIPKG-SNAKYEIDKETGPIKVDRFLYSSMGYPWNYGFIPQTLEDDGDPLDVLVIGEEPLFPGSVIRVRPLGV 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520909686  94 LKMTDESGEDAKVVAVPHSKLskEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAASARAEILTSYE 171
Cdd:cd00412   80 LKMIDEGETDWKVIAVPVDDP--RYSHINDISDVPPHLLDEIKHFFEHYKDLEGKKEVKVAGWKDKEEALKIIKESIE 155
Pyrophosphatase pfam00719
Inorganic pyrophosphatase;
18-174 5.44e-83

Inorganic pyrophosphatase;


Pssm-ID: 459915  Cd Length: 154  Bit Score: 241.52  E-value: 5.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   18 VVIEIPANaDPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPLIPGSVIRCRPVGVLKMT 97
Cdd:pfam00719   1 VVIEIPKG-SNAKYEIDKETGALRLDRVLFTSMGYPANYGFIPQTLEDDGDPLDVLVLGSEPTFPGCVVRVRPIGVLAMI 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520909686   98 DESGEDAKVVAVPHSklSKEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAASARAEILTSYERAQ 174
Cdd:pfam00719  80 DEGETDDKIIAVPVD--DPRYDDINDISDLPGHLLDEIEHFFEHYKDLEGKKNVKVDGWKDAEEAEKIIEEAIERYK 154
PRK02230 PRK02230
inorganic pyrophosphatase; Provisional
16-165 3.22e-41

inorganic pyrophosphatase; Provisional


Pssm-ID: 179388  Cd Length: 184  Bit Score: 136.72  E-value: 3.22e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  16 IYVVIEIPANADpIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPLIPGSVIRCRPVGVLK 95
Cdd:PRK02230   5 IEVTIEIPKGSN-IKYEYDRKTNKIVVDRILRGDFVYPANYGFIKEALDWDGDELDVLVYSDQKFLPGTVLNARIIGAMK 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  96 MTDESGEDAKVVAVPHSklSKEYDHIQDVNDLPELLKAQITHFFERYKELESGKWVKVDGWEDAASARAE 165
Cdd:PRK02230  84 MIDDGETDTKLIAVHDD--DYRLDHINSLKDLPQHWLDEIEYFFSNYKNWKRKGITKVKGFEDEKWALKE 151
PLN02373 PLN02373
soluble inorganic pyrophosphatase
9-169 5.04e-32

soluble inorganic pyrophosphatase


Pssm-ID: 178001  Cd Length: 188  Bit Score: 113.27  E-value: 5.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   9 GKSLPDDIYVVIEIPANADpIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHTLSLDGDPVDVLVPTPYPLIPGSVIRC 88
Cdd:PLN02373  18 GPGAPAIFNCVVEITKGSK-VKYELDKKTGLIKVDRVLYSSVVYPHNYGFIPRTLCEDNDPLDVLVLMQEPVLPGCFLRA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  89 RPVGVLKMTDESGEDAKVVAVPHSklSKEYDHIQDVNDLPELLKAQITHFFERYKELESgKWVKVDGWEDAASARAEILT 168
Cdd:PLN02373  97 RAIGLMPMIDQGEKDDKIIAVCAD--DPEYRHYTDIKELPPHRLAEIRRFFEDYKKNEN-KEVAVNDFLPAEAAIEAIQY 173

                 .
gi 520909686 169 S 169
Cdd:PLN02373 174 S 174
PRK00642 PRK00642
inorganic pyrophosphatase; Provisional
6-171 1.98e-23

inorganic pyrophosphatase; Provisional


Pssm-ID: 179080  Cd Length: 205  Bit Score: 91.64  E-value: 1.98e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686   6 VPAGKSLPDDIYVVIEI-PAnaDPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVNHT----LSL--------------D 66
Cdd:PRK00642  15 LSLGPDAPESVCCYIEItPF--DTVKYELDKATGYLKVDRPQKFSNFCPALYGFIPRTycgdLSGklsgeqsgredikgD 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  67 GDPVDVLVPTPYPLIPGSVI-RCRPVGVLKMTDeSGE-DAKVVAVPHSKLSkeYDHIQDVNDLPELLKAQITHFFERYKE 144
Cdd:PRK00642  93 GDPLDICVLTEKNITHGNILlQARPIGGLRMID-GGEaDDKIIAVLEDDLV--YGEIKDISECPGTLLDRLQHYFLTYKA 169
                        170       180
                 ....*....|....*....|....*....
gi 520909686 145 L--ESGKWVKVDGWEDAASARAEILTSYE 171
Cdd:PRK00642 170 TpgELIKGVEIVGIYGKEEAQKVIQLAHE 198
PLN02707 PLN02707
Soluble inorganic pyrophosphatase
28-143 2.77e-07

Soluble inorganic pyrophosphatase


Pssm-ID: 178309 [Multi-domain]  Cd Length: 267  Bit Score: 48.98  E-value: 2.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520909686  28 PIKYEVDKesGAVfvdRFMSAPMFYpcNYG----------YVNHTLSL---DGDPVDVLVPTPYPLIPGSVIRCRPVGVL 94
Cdd:PLN02707  96 PIKQDTKK--GKL---RDYPYNINW--NYGllpqtwedptHANPEVEGafgDNDPVDVVEIGERAAKIGEVLKVKPLGVL 168
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 520909686  95 KMTDESGEDAKVVAVP-HSKLSKEYDHIQDVND-LPELLKAqITHFFERYK 143
Cdd:PLN02707 169 AMIDEGELDWKVVAISaDDPKASLVNDVDDVEKhFPGTLTA-IRDWFRDYK 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH