|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
1-436 |
0e+00 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 726.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 1 MKIVPTLNNSTNMDtnQAYRYWRIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVS 80
Cdd:PRK11663 1 PADAPLITDKHEID--ARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 81 GLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNL 160
Cdd:PRK11663 79 GIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 161 SGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIWLCYRIQEKPTEMGLPSVGQWRNDALELEHEKEGQGLPFNAAVYRY 240
Cdd:PRK11663 159 GGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGAGLSRKEILTKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 241 VLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIF 320
Cdd:PRK11663 239 VLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 321 ALGIFASVAALWLTPVDHIGFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIE 400
Cdd:PRK11663 319 AAGILLSVGSLWLMPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLE 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 521099051 401 HWGWEGFFCLITAAAAVISLQLLPFIKAQQPNSDDE 436
Cdd:PRK11663 399 IWHWTGFFVVISIAAGISALLLLPFLNAQAPREASE 434
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
23-426 |
0e+00 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 536.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 23 RIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGI 102
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 103 VNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGF 182
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 183 IVPGCVAVLVGIWLCYRIQEKPtemglpsvgqwrndalelehekegqglpfnaavyryvltnRYIWLLCGSYLLVYVVRI 262
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP----------------------------------------PYIWLLAFCYVLVYVVRT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 263 AINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIFASVAALWLTPVDHIGFL 342
Cdd:cd17488 201 AINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVHSYWLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 343 AGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVISLQL 422
Cdd:cd17488 281 ATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLL 360
|
....
gi 521099051 423 LPFI 426
Cdd:cd17488 361 LPLL 364
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
31-408 |
2.01e-119 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 353.22 E-value: 2.01e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 31 YVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFS 110
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 111 SSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGF-ISLNFGWRYGFIVPGCVA 189
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 190 VLVGIWLCYRIQEKPTEMGLPSVGQWRNDALELEHEKEGQGLPFNAAVYRYVLTNRYIWLLCGSYLLVYVVRIAINDWGA 269
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 270 LYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIFASVAALWLTPVDHIGFLAGCFFCI 349
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFAL 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 521099051 350 GFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFF 408
Cdd:TIGR00881 321 GFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
23-426 |
2.86e-102 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 308.82 E-value: 2.86e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 23 RIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGI 102
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 103 VNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGF 182
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 183 IVPGCVAVLVGIWLCYRIQEKPtemglpsvgqwrndalelehekegqglpfnaavyryvltnRYIWLLCGSYLLVYVVRI 262
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP----------------------------------------PYVWVLSLAYAFVYIVRY 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 263 AINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIFASVAALWLTPvDHIGFL 342
Cdd:cd17312 201 ACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFP-HNKLLS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 343 AGCFFCIGFFVFGPQMMIGMAAAECA-RKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVISLQ 421
Cdd:cd17312 280 IVLLFLIGFFVGGPINLIGGAAAQDIgRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLL 359
|
....*
gi 521099051 422 LLPFI 426
Cdd:cd17312 360 LLSLW 364
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
23-416 |
4.71e-101 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 307.25 E-value: 4.71e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 23 RIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGI 102
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 103 VNIAFGF----SSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFG- 177
Cdd:cd17345 81 INILIGFvpsaTSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 178 --WRYGFIVPGCVAVLVGIwLCYRIQ-EKPTEMGLPSVGQWRNDALELEH-EKEGQGLPFNAAVYRYVLTNRYIWLLCGS 253
Cdd:cd17345 161 gwWRGAFIFPAIIAIIVAV-IVLFLGkDTPESEGLPPIEEYKGDYPEEADgEEEEQELSAWEIFVKYVLKNKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 254 YLLVYVVRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIFASVAALWL 333
Cdd:cd17345 240 NVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 334 TPVDHIGFLAgcFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYL-GAALASYPMSLAIEHWGWEGFFCLIT 412
Cdd:cd17345 320 APNVLVDLIA--LIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLL 397
|
....
gi 521099051 413 AAAA 416
Cdd:cd17345 398 ASCI 401
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
29-423 |
1.26e-83 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 262.27 E-value: 1.26e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 29 SMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFG 108
Cdd:cd17343 7 SMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 109 FSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCV 188
Cdd:cd17343 87 GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 189 AVLVGIWLCYRIQEKPTEMGLPSvgqwrndALELEHEKEGQGLPFNAAVYRYVLTNRYIWLLCGSYLLVYVVRIAINDWG 268
Cdd:cd17343 167 AVVMSVVCLLFIKNEPSDVGLNN-------IEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 269 ALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGN--------RAPMNLIFALGIFASVAAL--WLTPVDH 338
Cdd:cd17343 240 QLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHgsssrgnpRMPLALVFMAGLTVSLHLFrvHITSDSS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 339 IGFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCL--ITAAAA 416
Cdd:cd17343 320 ELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLleILCAIT 399
|
....*..
gi 521099051 417 VISLQLL 423
Cdd:cd17343 400 VVILFLL 406
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
19-424 |
1.33e-76 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 245.77 E-value: 1.33e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 19 YRYWRIQLMVSMYVGYAVFYLTRKSFNFALPgMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLL 98
Cdd:PRK11273 23 YRRLRWQIFLGIFFGYAAYYLVRKNFALAMP-YLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 99 ATGIVNIAFGF----SSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVA--IGFI 172
Cdd:PRK11273 102 LAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLflLGMA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 173 SLNfGWRYGFIVPGCVAVLVGIWLCYRIQEKPTEMGLPSVGQWRNDALELEHEKEGQGLPFNAAVYRYVLTNRYIWLLCG 252
Cdd:PRK11273 182 WFN-DWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKHEQELTAKQIFMQYVLPNKLLWYIAI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 253 SYLLVYVVRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIFASVAALW 332
Cdd:PRK11273 261 ANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYW 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 333 LTPVDHIGFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAAL-ASYPMSLAIEHWGWEGFFCLI 411
Cdd:PRK11273 341 LNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVM 420
|
410
....*....|...
gi 521099051 412 TAAAAVISLQLLP 424
Cdd:PRK11273 421 IGGSILAVILLIV 433
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-427 |
2.27e-62 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 205.87 E-value: 2.27e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 16 NQAYRYWRIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGL 95
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 96 GLLATGIVNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLN 175
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 176 FGWRYGFIVPGCVAVLVGIWlcyriqekptemglpsvgqwrndalelehekegqglpfnaavyryvltnrYIWLLCGSYL 255
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL--------------------------------------------------RFWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 256 LVYVVRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIfasVAALWLTP 335
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA---LALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 336 VDHIGFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAA 415
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
410
....*....|..
gi 521099051 416 AVISLQLLPFIK 427
Cdd:COG2271 348 LLAALLALLLLR 359
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
24-386 |
7.63e-55 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 189.10 E-value: 7.63e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 24 IQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIV 103
Cdd:PRK09556 28 MQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAIC 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 104 NIAFGFS-----SSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIpvaiGFISLnFGW 178
Cdd:PRK09556 108 MLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGA----GGVAL-WGA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 179 RY--------GFIVPGCVAVLVGIWlCYRI-QEKPTEMGLPSVGQWRNDALELEH-EKEGQGLPFNAAVYRYVLTNRYIW 248
Cdd:PRK09556 183 NYffdghvigMFIFPSIIALIIGFI-GLRYgSDSPEELGWGKAEEIFGEPISEEDkETESTDMTKWQIFVEYVLKNPVIW 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 249 LLCGSYLLVYVVRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRyFHGNRApmnLIFALGIFASV 328
Cdd:PRK09556 262 LLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL-ANGRRA---LVACIALALII 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 521099051 329 AALWL-TPVDHIGFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYL 386
Cdd:PRK09556 338 FTLGVyQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYL 396
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-392 |
3.12e-36 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 136.01 E-value: 3.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 30 MYVGYAVFYLTRKSFNFALP-GMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFG 108
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 109 FSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCV 188
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 189 AVLVGIWLCYRIQEKPTEmglpsvgqwrndalelEHEKEGQGLPFNAAVYRYVLTNRYIWLLCGSyLLVYVVRIAINDWG 268
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESK----------------RPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 269 ALYLVERHsFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhGNRAPMNLIFALGIFASVAALWLTPVDHIGFLAGCFFC 348
Cdd:pfam07690 224 PLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRL--GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 521099051 349 IGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALAS 392
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-417 |
2.27e-32 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 125.76 E-value: 2.27e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 23 RIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGI 102
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 103 VNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGF 182
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 183 IVPGCVAVLVGIwlcyriqekptemglpsvgqwrndalelehekegqglpfnaAVYRYVltnRYIWLLCGSYLLVYVVRI 262
Cdd:cd17319 161 IIEGLLGLLLAV-----------------------------------------LWWFYL---RQVWGLALGYFGINYALY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 263 AINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMnlIFALGIFASVAALWLTPVDHIGFL 342
Cdd:cd17319 197 GLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLV--IIIGLLLAAVGLLLAYLTTSPVVA 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521099051 343 AGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWG-WEGFFCLITAAAAV 417
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALL 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-391 |
7.95e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 113.15 E-value: 7.95e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 20 RYWRIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLA 99
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 100 TGIVNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWR 179
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 180 YGFIVPGCVAVLVGIWLCYRIQEKPTEMGLPSVGQWRNdalelehekegqglpfnaavyryVLTNRYIWLLCGSYLLVYV 259
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE-----------------------LLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 260 VRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhgnrAPMNLIFALGIFASVAALWLTPVDHI 339
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLLLLALAGSL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 521099051 340 GFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALA 391
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
34-420 |
1.51e-27 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 112.72 E-value: 1.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 34 YAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSL 113
Cdd:cd17475 5 QAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 114 LAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVG 193
Cdd:cd17475 85 PVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 194 I--WLCYRiqEKPTEMGLPSVGQWRNDALelehekegqglpfnaavyRYVLTNRYIWLLCGSYLLVYVVRIAINDWGALY 271
Cdd:cd17475 165 VlfWLFYR--EPPAASAATESASTLLRSL------------------KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 272 LVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFHGNR-APMNLIFALGIFASVAALWLTPVDHIGFLAGCFFCIG 350
Cdd:cd17475 225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRrPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521099051 351 FFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEH-----WGWEgFFCLITAAAAVISL 420
Cdd:cd17475 305 LFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAthsyaPAWL-ALALLLVLAALLLL 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-420 |
3.68e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 111.75 E-value: 3.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 30 MYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGF 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 110 SSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFI--SLNFGWRYGFIVPGC 187
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 188 VAVLVGIWLCYRIQEKPTEMGlpsvgqwrndaleleHEKEGQGLPFNAAVYRYVLTNRYIWLLCGSYLLVYVVRIAINDW 267
Cdd:cd06174 161 LALLAAILLLLVVPDPPESAR---------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 268 GALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYFhgnrAPMNLIFALGIFASVAALWLTPVDHIGFLAGCFF 347
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI----GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521099051 348 CIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVISL 420
Cdd:cd06174 302 LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-429 |
6.64e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.79 E-value: 6.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 32 VGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSS 111
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 112 SLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVL 191
Cdd:COG2223 92 SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 192 VGIWLCYRIQEKPTEMGLPSVGQWRNdalelehekegqglpfnaavYRYVLTNRYIWLLCGSYLLVYVVRIAINDWGALY 271
Cdd:COG2223 172 VAVLAWLFLRDPPAGAAAAAKASLRD--------------------QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 272 LVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhgNRAPMNLIFALGIFASVAALWLTPVDHIGFLAGCFFCIGF 351
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI---GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521099051 352 FVFGPQMMIGMAAAEcARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVISLQLLPFIKAQ 429
Cdd:COG2223 309 LGGGNGAVFALVPDI-FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
32-388 |
2.29e-20 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 92.40 E-value: 2.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 32 VGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSS 111
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 112 SLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVL 191
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 192 VGIWLCYRIQEKPTEMGL--PSVGQWRNDALELEHEKEGQGLPFNAAVyRYVLTNRYIWLLCGSYLLVYVVRIAINDWGA 269
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWltEEEKYIVVGGLLAEQQGKGPSTPKKYQI-KELLKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 270 LYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDrYFHgnRAPMNLIFA------LGIFASVAALWLTPVDhIGFLA 343
Cdd:TIGR00893 240 TYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSD-LLL--RRGKSLVFArktaiiAGLVLSLLMFATNYVN-IPYAA 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 521099051 344 GCFFCIGFfvFGPQMMIGMAA--AECARKDLAGTATGFIGLFSYLGA 388
Cdd:TIGR00893 316 LALVALGF--FGLGAGAIGWAliSDNAPGNIAGLTGGLINSLGNLGG 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-420 |
6.79e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.63 E-value: 6.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 48 LPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLwtvnAFFQ 127
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA----RFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 128 GWG----WPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIWLCYRIQEK 203
Cdd:cd17325 95 GLAsaavWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 204 PTemglpsvgqwrndalelEHEKEGQGLPFNAAVYRYVLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHSFDVLSA 283
Cdd:cd17325 175 RP-----------------PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 284 NSAVSMFEVGGFLGSLFGGWGSDRYfhgNRAPMnlIFALGIFASVAALWLTPVDHIGFLAGCFFCIGFFVFGPQMMIGMA 363
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRI---GRKPL--ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 521099051 364 AAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVISL 420
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-418 |
4.83e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 85.29 E-value: 4.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 23 RIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGI 102
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 103 VNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSER------GFWWSIWNTChnlsGALIPVAIGFISLNF 176
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlnllHAFFSLGALL----GPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 177 GWRYGFIVPGCVAVLVGIWLCYriqekpteMGLPsvgqwrndalelEHEKEGQGLPFNAAVYRYVLTNRYIWLLCGSYLL 256
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLR--------SKLP------------EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 257 VYVVRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhgNRAPMNLIFALGIFASVAALWLTPV 336
Cdd:COG0738 222 YVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---GPVRLLRLSALLAAVGLLLALLAPG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 337 DHIGFLAgcFFCIGFFVfGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAA 416
Cdd:COG0738 299 PWLALIG--LALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYL 375
|
..
gi 521099051 417 VI 418
Cdd:COG0738 376 LI 377
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
21-205 |
9.17e-17 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 81.53 E-value: 9.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 21 YWRIQLMVSMYvgYAVFYLTRKSFNFA-LPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLA 99
Cdd:cd17327 3 DLFILPLLCIL--YFLQYLDKSNISNAaVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 100 TGIVNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALipvaIGFISLNF--- 176
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIF----GGLLAYGVfki 156
|
170 180 190
....*....|....*....|....*....|....*.
gi 521099051 177 -------GWRYGFIVPGCVAVLVGIWLCYRIQEKPT 205
Cdd:cd17327 157 lgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPS 192
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
62-198 |
5.52e-15 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 76.20 E-value: 5.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 62 LGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFS-----SSLLAFTLLWTVNAFFQGWGWPACAK 136
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGyywniHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521099051 137 ILTSWYSRSERGFWWSIWNTcHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIwLCY 198
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWNS-HTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGV-LVF 203
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
62-204 |
5.31e-14 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 73.12 E-value: 5.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 62 LGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAF------TLLWTVNAFFQGWGWPACA 135
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVV 144
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521099051 136 KILTSWYSRSERGFWWSIWNTCH---NLSGALIPVAIgfisLNFGWRYGFIVPGCVAVLVGIWLCYRIQEKP 204
Cdd:cd17342 145 AIMGNWFGKSSRGFVLGLWSACAsvgNIIGALLASSV----LDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP 212
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
47-420 |
1.23e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 68.76 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 47 ALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLwtvnAFF 126
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIA----RFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 127 QGWGWPACA----KILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIWLCYRIQE 202
Cdd:cd17320 97 QGLGAAAGSvvarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 203 KPTEmglpsvgqwrndalelehEKEGQGLPFNAAVYRYVLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHSFDVls 282
Cdd:cd17320 177 TLPE------------------EKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSP-- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 283 anSAVSMFEVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIFAsVAALWLTPVDHIG------FLAGCFFCigFFVFGP 356
Cdd:cd17320 237 --AQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLL-AAALVLLLAALLGglslwpLVAPLFLI--FFGFGL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521099051 357 QMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGW-EGFFCLITAAAAVISL 420
Cdd:cd17320 312 IFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALpMGLLILVLGLLALLLL 376
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
23-202 |
2.47e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.14 E-value: 2.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 23 RIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGI 102
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 103 VNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGF 182
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180
....*....|....*....|
gi 521099051 183 IVpGCVAVLVGIWLCYRIQE 202
Cdd:COG0477 172 LI-NAPLGLLALVLRLRLPE 190
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-403 |
9.57e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.04 E-value: 9.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 48 LPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSS---LLAFTLLWTV-N 123
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNywlLLLLVALAGIgS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 124 AFFQgwgwPACAKILTSwYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIWLcyriqek 203
Cdd:cd17478 99 AAFH----PEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLL------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 204 ptemglpsvgqWRNDALELEHEKEGQGLPFNAAVYRyvLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHsFDVLSA 283
Cdd:cd17478 167 -----------LRLRPLKKPEAKKAAAKSSARSTLK--GVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 284 NSAVSMFEVGGFLGSLFGGWGSDRYfhGNRApmnlIFALGIFASVAALWLTPVDHIGFLAGCFFCIGFFVFGPQMMIGMA 363
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRF--GRRR----VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 521099051 364 AAECARKDlAGTATGFIGLFSYLGAALASYPMSLAIEHWG 403
Cdd:cd17478 307 AQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFG 345
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
48-417 |
2.64e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.89 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 48 LPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNAFFQ 127
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 128 GWGWPACAKILTSWYSRSeRGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGI-WLCYRIQEKPTE 206
Cdd:COG2807 121 AVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLlWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 207 MGLPSVGQWRNdalelehekegqglpfnaavyryVLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHsFDVLSANSA 286
Cdd:COG2807 200 AAAPAAASLRS-----------------------LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAG-LSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 287 VSMFEVGGFLGSLFGGWGSDRyfHGNRAPMNLIFALGIFASVAALWLTPVDHIGFLAgcfFCIGFFVFGPQMMIGMAAAE 366
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADR--LGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA---VLLGLGQGGLFPLALTLIGL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 521099051 367 CAR-KDLAGTATGFIGLFSYLGAALASYPMSLAIEHWG-WEGFFCLITAAAAV 417
Cdd:COG2807 331 RARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVL 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-196 |
3.97e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.13 E-value: 3.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 26 LMVSMYVGYAVFYLTRKSFNFALPGMLTDL-GLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVN 104
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 105 IAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIV 184
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|..
gi 521099051 185 PGCVAVLVGIWL 196
Cdd:cd17325 360 AAALLLLAAVLF 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
48-420 |
7.28e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 63.34 E-value: 7.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 48 LPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNAFFQ 127
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 128 GWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIWLCYRiqekptem 207
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL-------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 208 gLPSvgqwrndaleLEHEKEGQGLPFnaAVYRYVLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHSFDVLSANSAV 287
Cdd:cd17324 174 -LPS----------LPPKKPGSLGLL--SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 288 SMFEVGGFLGSLFGGWGSDRYFHGNrapmNLIFALGIFASVAALWLTPVDHIGFLAGCF-FCIGFFVFGP--QMMIGMAA 364
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVlWGLGFFAAHSalQTRVLRLA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 521099051 365 aecarKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGfFCLITAAAAVISL 420
Cdd:cd17324 317 -----PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAG-VGWVGAALLLLAL 366
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-420 |
2.14e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.77 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 27 MVSMYVGYAVFYLTRKSFNFALPGM--LTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVN 104
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 105 IAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHN----LSGALIPVAIGFISLNFGWRY 180
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 181 GFIVpGCVAVLVGIWLCYRIqekptemglpsvgqwrndalelehekegqglpfnaavyryvltnryiWLLCGSYLLVYVV 260
Cdd:cd17316 161 LFLI-GALPALLALLLRRRT-----------------------------------------------LLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 261 RIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhgNRAPMNLIFALGIFASVAALWLTPVDHIG 340
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLVIGLILSGILALPLFYLLSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 341 FLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVISL 420
Cdd:cd17316 270 LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
41-393 |
5.86e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.67 E-value: 5.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 41 RKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLW 120
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 121 TVNAFFQ-GWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIWLCYR 199
Cdd:cd17355 99 GLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 200 IQEKPTEMGLPSVgqwrndalelehekEGQGLPFNAAVYRYVLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHsFD 279
Cdd:cd17355 179 LRRRPADLALRAY--------------DDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG-IS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 280 VLSANSAVSMFEVGGFLGSLFGGWGSDRYfhGNRAPMNLIFALGIFASVAALWLTPVDHIGFLAGCFFciGFFVFGPQMM 359
Cdd:cd17355 244 PAAAAVALALIGLFNIVGRLLSGWLGDRY--SPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF--GLGWGATVPL 319
|
330 340 350
....*....|....*....|....*....|....
gi 521099051 360 IGMAAAECARKDLAGTATGFIGLFSYLGAALASY 393
Cdd:cd17355 320 TAALAARYFGARSYGTLFGLVFAPHQLGSALGPW 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
26-420 |
1.58e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.06 E-value: 1.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 26 LMVSMYVGYAVFYLtrksFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNI 105
Cdd:cd17489 1 ILLANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 106 AFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVP 185
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 186 GcVAVLVGIWLCYRIQEKPTemglpsvgqwrndalelEHEKEGQGLPFnaavYRYVLTNRYIWLLCGSYLLVYVVRIAIN 265
Cdd:cd17489 157 A-VLALLALLLVFLVKDPPP-----------------VAAEEAEAGTR----AFRRLVEKKVLPPALILFLASIAYGAIS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 266 DWGALYLVERHSFD---VLSANSAVSMFevggflGSLFGGWGSDRYfhgNRAPMNLIFALGIFASVAALWLTPVDHIGFL 342
Cdd:cd17489 215 TFLPLYAAERGISNaglFFTVYAIALLL------SRPFSGKLSDRK---GPKTVIIPGLLLLALGLLLLSFAGSPWMLLL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521099051 343 AGCFFCIGFFVFGPqmMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFcLITAAAAVISL 420
Cdd:cd17489 286 AAVLYGLGFGLLFP--ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF-LLAAVVVLLAL 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
54-417 |
2.73e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 2.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 54 DLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNAFFQGWGWPA 133
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 134 CAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFIsLNFGWRYGFIVPGCVAVLVGIWLCYRIQEkptemglpsvg 213
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPE----------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 214 qWRNDALELEHEKEGQGLPF---NAAVYRYVLTNRYIWLL---CGSYLLVYVVRIAIN---DWGALYLVErhsfdvlSAN 284
Cdd:cd17329 177 -TRPKRRAAEKTEILRGYKIvlrDRAFLLFLLASFLISLIyfqLESTLPVYVVEILGLgesLLGLLLALN-------ALL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 285 SAVSMFEVGGflgslfggwgsdryFHGNRAPMNLIFALGIFASVAALWLTPVDHIG--FLAGCFFCIGFFVFGPqmMIGM 362
Cdd:cd17329 249 IVLLQFPVAR--------------LVERFRLRKILMIGILLFAIGFAVLAFANTLAvlILAMIVLTLGEMLVFP--AVQT 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 521099051 363 AAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWG----WEGFFCLITAAAAV 417
Cdd:cd17329 313 LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGpglpWLILAALGLIAAAL 371
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
26-200 |
5.20e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 5.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 26 LMVSMYVGYAVFYLTRKSFNFALPGML-TDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDH-SRSRYFMGLGLLATGIV 103
Cdd:cd17474 199 GLLTFLVSAFLYFFLYFAFLTYLPFLLeLLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALS 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 104 NIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFI 183
Cdd:cd17474 279 LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358
|
170
....*....|....*..
gi 521099051 184 VpGCVAVLVGIWLCYRI 200
Cdd:cd17474 359 V-GAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-392 |
5.36e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.44 E-value: 5.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 24 IQLMVSMYVGYAVFYLTrksfnfalpgmlTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRY-----FMGLGLL 98
Cdd:COG2211 22 LNLAFGLLSAYLLYFYT------------DVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 99 ATGIVNIAFGFSSS----------LLAFTLLWTVNAFFQG--WGWPAcakILTSwySRSERGFWWSIWNTCHNLSGALIP 166
Cdd:COG2211 90 PLALSFVLLFTAPDlsptgkliyaLVTYLLLGLAYTLVNIpySALGA---ELTP--DYEERTRLSSWRFAFAGLGGLLAS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 167 VAIGFISLNF------GWRYGFIVPGCVAVLVGIWLCYRIQEKPTEmglpsvgqwrndalelehekEGQGLPFnAAVYRY 240
Cdd:COG2211 165 VLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVP--------------------EEEKVSL-KESLKA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 241 VLTNRYIWLLCGSYLLVYVVrIAINDWGALYLVERHSFDVLSANSAVSMFE-VGGFLGSLFGGWGSDRYfhGNRAPMNLI 319
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLA-LALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRF--GKKKAFIIG 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521099051 320 FALGIFASVAALWLTPVDHIGFLAGCF---FCIGFFVFGPQMMIGMAAAECARK---DLAGTATGFIGLFSYLGAALAS 392
Cdd:COG2211 301 LLLAALGLLLLFFLGPGNLWLLLVLAAlagIGLGAILVLPWAMLADVVDYDEWKtgrRREGLYFGIFTFAIKLGQALAG 379
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
44-424 |
1.30e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.38 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 44 FNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDhsrsRYFMGLGLLATGIVniaFGFSSSLLAFTLLWTVN 123
Cdd:cd17371 18 LGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILAD----RFGRVRVLVITILL---FAVFTLLCGFAQNYWQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 124 A---FFQGWG----WPACAkILTSWYSRSER-----GFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVpGCVAVL 191
Cdd:cd17371 91 LilrALAGLGfggeWAAGA-ALMAEYVPARHrgkalGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLL-GALPAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 192 VGIWLCYRIQEKPtemglpsvgQWRNDALELEHEKEG--QGLPFNAAVYRyvLTNRYIWLLCGSYLLVYvvriAINDWGA 269
Cdd:cd17371 169 LVLFIRRFVKEPP---------QWQAARAARRHFADRpsLRELFSPPLLR--TTLLASLLATGALGGYY----GITTWLP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 270 LYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhgNRAPMNLIFALGIFASVAALWLTPVDHIGFLAGCFFCi 349
Cdd:cd17371 234 SYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI---GRRNNFALFALGSAISILLYFFLPLSPTLILILGFPL- 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521099051 350 GFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWE---GFFCLITAAAAVISLQLLP 424
Cdd:cd17371 310 GFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGtaiAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-196 |
1.58e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.88 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 21 YWRIQLMVSMYVGYAVFYLTRKSFNFALPGMLTD-LGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHS---RSRYFMGLG 96
Cdd:cd17319 175 WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 97 LLATGIVNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFI-SLN 175
Cdd:cd17319 255 LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLvDAT 334
|
170 180
....*....|....*....|.
gi 521099051 176 FGWRYGFIVPGCVAVLVGIWL 196
Cdd:cd17319 335 GSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-393 |
2.96e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.16 E-value: 2.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 30 MYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMID-HSRsRYFMGLGLLATGIVNIAFG 108
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDrYNR-KWILAVGILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 109 FSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNL-SGALIPVAIGFISLNFGWRYGFIVPGC 187
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLgSGLGYVVGGLVAQATGGWRWAFRVTGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 188 VAVLVGIWLCYRIQEKPtemglpsvgqwRNDALELEHEKEGQGLPFNAAvyRYVLTNR-YIWLLCGSYLLVYVVRiAIND 266
Cdd:cd17328 163 LGVLLAILLLLFVREPP-----------RGAAEGGVMAKSTATSFLADL--KALAKNPsFILSTLGFTAVSFVTG-ALAF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 267 WGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWG----SDRYFHGNRAPMNLIFALGIFASVAALWLTPV---DHI 339
Cdd:cd17328 229 WAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLggilADRLRRKTPRADPLVCAVGLLAAAPFLFLALVlalSNL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 521099051 340 GFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSY-LGAALASY 393
Cdd:cd17328 309 LLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPY 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
44-194 |
6.75e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.81 E-value: 6.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 44 FNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSR-YFMGLGLLATGIVNIAFGFSSSLLAFTLLWTV 122
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521099051 123 NAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFI-SLNFGWRYGFIVPGCVAVLVGI 194
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-418 |
1.40e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.93 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 30 MYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGF 109
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 110 SSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSeRGFWWSIWNTCHNLSGALIPVAIG-FISLNFGWRYGFIVPGCV 188
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 189 AVLVGI-WLCYRIqekptemglpsvgqwrnDALELEHEKEGQGLPFNAAVYRYvLTNRYIWLLCGSYLLVYVVRIAINDW 267
Cdd:cd17333 160 YLLLAIlILLTLF-----------------PELPSARNPQQSVGAFSASASRL-LRNPSIILGALALFLYVGAETAFSSW 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 268 GALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhgnrAPMNLIFALGIFASVA--ALWLTPVDHIGFLAgc 345
Cdd:cd17333 222 VPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI-----KPHTLLVLSGSGALLGllILLLAPTLVVGLVA-- 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521099051 346 FFCIGFFVfGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVI 418
Cdd:cd17333 295 TALLGLFM-AALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAII 366
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-196 |
2.27e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 2.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 19 YRYWRIQLMVSMYVGYAVFYLTRKSFNFALPGMLTD-LGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGL 97
Cdd:cd06173 202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 98 LATGIVNIAFGFSSSLLAFTLLWTVNAFFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFG 177
Cdd:cd06173 282 LLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG 361
|
170
....*....|....*....
gi 521099051 178 WRYGFIVPGCVAVLVGIWL 196
Cdd:cd06173 362 LSAVFLLAGALLLLAALLL 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
47-423 |
2.70e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 47 ALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSS---LLAFTLLWTV- 122
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSfalLLAGRALQGIg 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 123 NAFFQgwgwPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLnFGWRYGFIVPGcVAVLVGIWLCYRIQE 202
Cdd:cd17474 101 AAGLG----PLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA-ALIPVAFLAILFLLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 203 KPTEMGLPSVGQWRNDALELEHEKEGQGLPFNAAVYRYVLTNryiwllcgsyLLVYVVRIAINDWGALYLVERHSFDVLS 282
Cdd:cd17474 175 EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFA----------FLTYLPFLLELLYGISPIIIGLLFAGWS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 283 ANSAVSMFEVggflgslfggwgsdRYFHGNRAPMNLIFALGIFA-SVAALWLTPVDHIGFLAGC--FFCIGFFVFGPQMM 359
Cdd:cd17474 245 VLLALGSLFV--------------GRLLKKRFGARRILVIGLLLyALSLLLLGFVPSLALLLIAivLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521099051 360 IgmAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFcLITAAAAVISLQLL 423
Cdd:cd17474 311 T--LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF-LVGAAIALAAAVLL 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-391 |
6.57e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 6.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 45 NFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMID-HSRSRYFMgLGLLATGIVNIAFGFSSSLLAFTLLwtvn 123
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDrFGRKRVFL-IGLALFGLASLLCALAPSLAFLIAA---- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 124 AFFQGWG----WPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVgiwlcyr 199
Cdd:cd17321 91 RALQGIGaaaiMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 200 iqekptemglpsvgqwrndalelehekegqglpfnaavyrYVLTNRYIWLLCGSyLLVYVVRIAINDWGALYLVERHSFD 279
Cdd:cd17321 164 ----------------------------------------LLLARTFSGAVLAA-FLLGAALGGLLFLLPLYLQGVLGYS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 280 VLSANSAVSMFEVGGFLGSLFGGWGSDRYfhGNRAPMNLIFALGIFASVAALWLTPVDHIGFLAGCFFCIGF---FVFGP 356
Cdd:cd17321 203 PLQAGLALLPLALAMLVAAPLAGRLADRF--GPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLglgLFATP 280
|
330 340 350
....*....|....*....|....*....|....*
gi 521099051 357 QMMIGMAAAEcarKDLAGTATGFIGLFSYLGAALA 391
Cdd:cd17321 281 LTNAALSSVP---KEKAGAASGILNTARQLGGALG 312
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
64-192 |
9.30e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.53 E-value: 9.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 64 LLGTLFYlTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVN----IAFGFSSSLLAFtlLWTVNAFFQGWGWPACAKILT 139
Cdd:cd17318 61 ILSSFFY-GYILTQIPGGYLAEKYGAKRVLGYSILITALLTlltpLAARGGYGALIV--LRILQGLAQGVTFPAMHALWA 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 521099051 140 SWYSRSERGFWWSIwntchNLSGALIPVAI-----GFISLNFGWRYGFIVPGCVAVLV 192
Cdd:cd17318 138 KWAPPLERSRLTSI-----AYSGSQFGTVIamplsGFLCESLGWPSIFYIFGGLGLLW 190
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
48-217 |
1.41e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.83 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 48 LPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNAFFQ 127
Cdd:cd06180 22 LPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 128 GWGWPACAKILTSWYSRSERGFWWSiWNTCHN-----LSGALIPVAIGF-ISLNFGWRYGFIVPGCVAVLVgIWLCYRIQ 201
Cdd:cd06180 102 AFVFVFGSNLVLHHATAAGRGHLIG-LLFAGVglgiaLSGLLVPAGLGGgLSWRAGWLALALLSAVLLLLS-FLLLRRGP 179
|
170
....*....|....*.
gi 521099051 202 EKPTEMGLPSVGQWRN 217
Cdd:cd06180 180 SAPTEASAAESAPGLN 195
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
46-393 |
6.03e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.96 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 46 FALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNAF 125
Cdd:TIGR00895 38 FAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 126 FQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWR----YGFIVPGCVAVLVGIWLCYRI- 200
Cdd:TIGR00895 118 GLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRslfyVGGIAPLLLLLLLMRFLPESId 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 201 --QEKPTEMGL-------PSVGQWRNDALELEHEKEGQGLPFNAAVYRYVlTNRYIWLLCGSYLLVYVVRIAINDWGALY 271
Cdd:TIGR00895 198 flVSKRPETVRrivnaiaPQMQAEAQSALPEQKSTQGTKRSVFKALFQGK-TARITVLLWLLYFMLLVGVYFLTNWLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 272 LVERhSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhGNRAPMNLIFALGIFASVAALWLTPVDHIGFLAgcfFCIGF 351
Cdd:TIGR00895 277 MVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRL--GPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLG---AIAGF 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 521099051 352 FVFGPQMMIGMAAAECARKDLAGTATGF---IGLF-SYLGAALASY 393
Cdd:TIGR00895 351 FVNGGQSGLYALMALFYPTAIRATGVGWaigIGRLgAIIGPILAGY 396
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
45-194 |
7.18e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.79 E-value: 7.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 45 NFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNA 124
Cdd:cd17503 16 NVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQG 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521099051 125 FFQGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFI--VPGCVAVLVGI 194
Cdd:cd17503 96 FGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYinLPIGILALLLA 167
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
48-420 |
1.72e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.32 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 48 LPGMLTDLGLDYSDLGLLgtLFYLTYG--ISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLwtvnAF 125
Cdd:cd17393 22 IPAIKDRLGLSDAALGLL--LLALGVGalVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALA----LF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 126 FQGWGWPACAKILTSWYSRSERGFWWSIWNTCH------NLSGALIPVAIGFISLNFGWRYG-FIVPGCVAVLVGIWLCy 198
Cdd:cd17393 96 LFGAANGALDVAMNAQGVAVERAYGRPIMSSLHamwslgGLAGALLGAAAIGAGVSPGVHLLaAAVLLLLAALVAIRAL- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 199 riqekptemglpsvgqWRNDALELEHEKEGQGLPfnaavyRYVLTNRYIWLLCGSYLLVYVVRIAINDWGALYLVERHSF 278
Cdd:cd17393 175 ----------------LPGTGEAAEDRPDGAGKP------GFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 279 DVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhGNRAPMN---LIFALGIFASVAALWlTPVDHIGF-LAGCFFCIGFfvf 354
Cdd:cd17393 233 SAALAALGYAVFSLAMTVGRLFGDRLVDRF--GDVAVLRagaLLAALGLLLALLAPS-VWVALAGFaLMGLGLSVVV--- 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521099051 355 gPQMmigMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFCLITAAAAVISL 420
Cdd:cd17393 307 -PLA---FSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVAL 368
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
27-198 |
2.09e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 27 MVSMYVGYA-VFYLTrksfnfalPGMLTDLGLDYSDLGLLGTLFYLTYGI-SKFVSGLMIDHSRSRYFMGLGLLATGIVN 104
Cdd:cd17490 204 ILQQMITFStTFGFT--------PLIAKQLGASSFQLGLLSIIYLLPNALaSLLSGTLFYKKLGERNTIIIGFLLLGAYC 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 105 IAFGFSSSLLAFTLLWTVNAFFQGWGWPACA----KILTSWYSRSERGFWWSIWNtchnLSGALIPVAIGFISLNFGWRY 180
Cdd:cd17490 276 FLIPFAPNLTLLYLLQALNGFGTGILFPLLMslsiEGVPAEQRSTAMGFFQAIYA----LGMFLGPVLVGIISEAFGLQT 351
|
170
....*....|....*...
gi 521099051 181 GFIVPGCVAVLVGIWLCY 198
Cdd:cd17490 352 GFFVIGVIALLAAILSLA 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-166 |
2.36e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 18 AYRYWRIQLMVSMYVGYAVFYLTRKSFNFALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGL 97
Cdd:pfam07690 193 AWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521099051 98 LATGIVNIAFGFSSSLLAFTLLWTVNAFF---QGWGWPACAKILTSWYSRSERGFWWSIWNTCHNLSGALIP 166
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLgfgFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
48-194 |
2.80e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.91 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 48 LPGMLTD-LGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRY----------FMGLGLLATGIVNIAFGF-SSSLLA 115
Cdd:cd17318 222 LPTYMSDvLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGilstttvrklFTSIGFLGPGVFLIALGYlGSNATL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 116 FTLLWTVNAFFQGWGW-----------PACAKILTswysrsergfwwSIWNTCHNLSGALIPVAIGFISLN----FGWRY 180
Cdd:cd17318 302 AVVFLTLSVGLSGACYsgflvnhldlaPNYAGTLM------------GITNTAATIAGIISPLIVGAIVKNdqtiGQWRI 369
|
170
....*....|....
gi 521099051 181 GFIVPGCVAVLVGI 194
Cdd:cd17318 370 VFFISAAIYILGAI 383
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
32-391 |
3.32e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.60 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 32 VGYAVFYLTrksFNFALPGMLTD-LGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRY-----FMGLGLLATGIVNI 105
Cdd:pfam13347 7 LAAGIKYAG---LATYLLYFYTDvLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWgrrrpWLLLSAIILAVSFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 106 AF----GFSSSLLAFTLLWTVNAFFQGWGW---PACAKILTSWYSRSERGFWWSIWNTCHNLSG---ALIPVAIGFI--- 172
Cdd:pfam13347 84 LLftppELGRAPLFIWLLATYILLRIAYTFfeiPYWSLGPELTRDYDERTSLTSYRSFFSVGGGllaAALAFPLVLIlgg 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 173 --SLNFGWRyGFIVPGCVAVLVGIWLCYRIQEKPTEMGLPsvgqwrndalelEHEKEGQGLPFNAAVyRYVLTNRYIWLL 250
Cdd:pfam13347 164 tgLERKGYR-IFALIGAVLMLLGVIITAAGTKERVSMRSK------------EDTGQKEAGSLLDML-KEVFRNRAFLIL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 251 CGSYLLVYvVRIAINDWGALYLVErhsfDVLSANSAVSMF--EVGGFLGSLFGGWGSDRYFHGNRAPMNLIFALGIFASV 328
Cdd:pfam13347 230 LASFLLAA-LAMGVLNGLLLYYFR----YVLGNGFAASAFplVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFA 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521099051 329 AALWLTPVDHIGFLAGCF---FCIGFFVFGPQMMIGMAAAECARK---DLAGTATGFIGLFSYLGAALA 391
Cdd:pfam13347 305 LALLLGPNNTLLFLVLYIiigFGYGSSFFLPWSMLADVVDYGELRtgkRREGTFFAMWSFISKLATGVG 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-194 |
4.99e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.07 E-value: 4.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 51 MLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLWTVNAFFQGWG 130
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521099051 131 WPAC-AKILTSWYSRSERGFwwSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGI 194
Cdd:COG0738 317 FPTIfSLALDGLGKRTAAAV--SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
67-195 |
5.32e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 67 TLFYLTYGI----SKFVSGLMIDHSRSRYFMGLGLLATGIVNIAFGFSSSLLAFTLLwtvnAFFQGWGWPACAKILTSWY 142
Cdd:cd17489 230 GLFFTVYAIalllSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA----AVLYGLGFGLLFPALQALA 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 521099051 143 SR----SERGFWWSIWNTCHNLSGALIPVAIGFISLNFGWRYGFIVPGCVAVLVGIW 195
Cdd:cd17489 306 VDlvppHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
250-423 |
5.65e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 5.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 250 LCGSYLLVYVVRIAINDWGALYLVERHSFDVLSANSAVSMFEVGGFLGSLFGGWGSDRYfhGNRAPMNLIFALGIFASVA 329
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--GRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 330 ALWLTPvdhIGFLAGCFFCIGFFVFGPQMMIGMAAAECARKDLAGTATGFIGLFSYLGAALASYPMSLAIEHWGWEGFFC 409
Cdd:pfam07690 79 LLFASS---LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170
....*....|....
gi 521099051 410 LITAAAAVISLQLL 423
Cdd:pfam07690 156 ILAILSLLAAVLLL 169
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
46-180 |
7.68e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 38.37 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 46 FALPGMLTDLGLDYSDLGLLGTLFYLTYGISKFVSGLMIDHSRSRYFMGLGLlatgIVNIAFGFSSSLL----AFTLLWT 121
Cdd:cd17438 20 FVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISL----AINASFAFLSSFVqgygAFLFCRL 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099051 122 VNAFFQGWGWPACAKILTSWYSRSERGFWWSiWNTCHNLSGALIPVAIGF-ISLNFGWRY 180
Cdd:cd17438 96 ISGFGIGGSLPIVFAYFSEFLAREKRGEHLS-WLCMFWMIGGLYASAMAWsIIPHYGWGF 154
|
|
| |
