|
Name |
Accession |
Description |
Interval |
E-value |
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
301-589 |
4.02e-88 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 277.83 E-value: 4.02e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 301 VFAIVYLAILLAHHRQVRQRQIEQLQVEAKQKLEFLVMERTAKLHAEIDERIRTEQALRQTQNELIQAAKLAVLGQMSAS 380
Cdd:COG4191 69 LALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 381 ISHELNNPLAAIRSFADNSRRFLA-NGKSERTDENLARISALTERMAKISEQLKSFARKSSsDEKADVQLYPIVVYAKEL 459
Cdd:COG4191 149 IAHEINNPLAAILGNAELLRRRLEdEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE-EEREPVDLNELIDEALEL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 460 MQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQALDGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKM 539
Cdd:COG4191 228 LRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVL 307
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 521099088 540 AHLFEPFFTTK--QNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:COG4191 308 ERIFEPFFTTKpvGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
353-589 |
4.45e-57 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 196.22 E-value: 4.45e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 353 RTEQalRQTQNELIQAAKLAVLGQMSASISHELNNPLAAIRSFADNSRRFLangKSERTDENLARISALTERMAKISEQL 432
Cdd:COG3852 116 ITER--KRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLEREL---PDDELREYTQLIIEEADRLNNLVDRL 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 433 KSFARKSSSdEKADVQLYPIVVYAKELMQPQFKSH-YIELNIQTPLEPVWAsvNPIQLEQVLINLLTNAMQALDGQ---- 507
Cdd:COG3852 191 LSFSRPRPP-EREPVNLHEVLERVLELLRAEAPKNiRIVRDYDPSLPEVLG--DPDQLIQVLLNLVRNAAEAMPEGgtit 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 508 ----ESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGAR 583
Cdd:COG3852 268 irtrVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTT 347
|
....*.
gi 521099088 584 FTIHLP 589
Cdd:COG3852 348 FRIYLP 353
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
364-595 |
7.42e-56 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 194.41 E-value: 7.42e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 364 ELIQAAKLAVLGQMSASISHELNNPLAAIRSFADNSRRFLANGKS---ERTDENLARISALTERMAKISEQLKSFARKSS 440
Cdd:COG5000 191 ELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEedrEDLERALDTIIRQVDRLKRIVDEFLDFARLPE 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 441 SdEKADVQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQALdgQESRKVAMTLLSDS 520
Cdd:COG5000 271 P-QLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAI--EEGGEIEVSTRRED 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521099088 521 DGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLPPLTAPA 595
Cdd:COG5000 348 GRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
276-589 |
1.03e-52 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 183.57 E-value: 1.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 276 LTIRVLSPKMNVFWDVFGFVMILTMVFAIVYLAILLAHHRQVRQRQIEQLQVEAKQKLEFLVMERTAKLHAEIDERIRTE 355
Cdd:COG0642 10 LLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 356 QALRQTQNELIQAAKLAV--LGQMSASISHELNNPLAAIRSFADnsrrFLANGKSERTDENLARISALTERMAKISEQLK 433
Cdd:COG0642 90 LLLLLLLLALLLLLEEANeaKSRFLANVSHELRTPLTAIRGYLE----LLLEELDEEQREYLETILRSADRLLRLINDLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 434 SFARKSSSD---EKADVQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQAldGQESR 510
Cdd:COG0642 166 DLSRLEAGKlelEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKY--TPEGG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 511 KVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTK----QNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTI 586
Cdd:COG0642 244 TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDpsrrGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTV 323
|
...
gi 521099088 587 HLP 589
Cdd:COG0642 324 TLP 326
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
339-573 |
2.08e-50 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 184.50 E-value: 2.08e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 339 ERTAKLHAEIDERIRTEQALRQTQNELIQAAKLAVLGQMSASISHELNNPLAAIRSFADNSRRFLANGKSERTDENLARI 418
Cdd:COG4192 398 EKTQELETEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKI 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 419 SALTERMAKISEQLKSFARKSSSDEKAdVQLYPIVVYAKELMQPQFKSHYIELNIQTPLepvWASVNPIQLEQVLINLLT 498
Cdd:COG4192 478 EGLIERMDKIIKSLRQFSRKSDTPLQP-VDLRQVIEQAWELVESRAKPQQITLHIPDDL---MVQGDQVLLEQVLVNLLV 553
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521099088 499 NAMQALDGQesRKVAMTLLSDSDGTLIHVDDNGPGIG-QDKmahLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLT 573
Cdd:COG4192 554 NALDAVATQ--PQISVDLLSNAENLRVAISDNGNGWPlVDK---LFTPFTTTKEVGLGLGLSICRSIMQQFGGDLY 624
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
357-589 |
5.74e-49 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 170.47 E-value: 5.74e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 357 ALRQTQNELIQAAKLavLGQMSASISHELNNPLAAIRSFADNSRRFLANGKSERtDENLARISALTERMAKISEQLKSFA 436
Cdd:COG2205 1 ELEEALEELEELERL--KSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEER-RELLEIIRESAERLLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 437 RKSS---SDEKADVQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQAldGQESRKVA 513
Cdd:COG2205 78 RLESgklSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKY--SPPGGTIT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 514 MTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFF----TTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:COG2205 156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
260-589 |
6.16e-49 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 175.13 E-value: 6.16e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 260 IKGDFIVSSRQLSMPDLTIRVLSPKMNVFWDVFGFVMILTMVFAIVYLAILLAHHRQVRQRQIEQLQVEAKQKLEFLVME 339
Cdd:COG5002 63 LLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 340 RTAKLHAEIDERIRTEQALRQTQNELIqaaklavlgqmsASISHELNNPLAAIRSFADNSRRfLANGKSERTDENLARIS 419
Cdd:COG5002 143 LGLLLLAAVERDITELERLEQMRREFV------------ANVSHELRTPLTSIRGYLELLLD-GAADDPEERREYLEIIL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 420 ALTERMAKISEQLKSFAR---KSSSDEKADVQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINL 496
Cdd:COG5002 210 EEAERLSRLVNDLLDLSRlesGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 497 LTNAMQAldGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTT------KQNGLGLGLSISQQIIQSMNG 570
Cdd:COG5002 290 LDNAIKY--TPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVdksrsrETGGTGLGLAIVKHIVEAHGG 367
|
330
....*....|....*....
gi 521099088 571 DLTASVSPLGGARFTIHLP 589
Cdd:COG5002 368 RIWVESEPGKGTTFTITLP 386
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
361-589 |
6.06e-40 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 149.55 E-value: 6.06e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 361 TQNELIQAAKLAVLGQMSASISHELNNPLAAIRSFAdnsrRFLANGKS-ERTDENLARISALTERMAKISEQLKSFARKS 439
Cdd:COG5807 134 AEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFL----QLLQESREdSEREEYFNIIISEIDRINTIITELLVLSKPK 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 440 SSDEKAdVQLYPIVVYAKELMQPQFKSHYI--ELNIQtPLEPVwASVNPIQLEQVLINLLTNAMQALdgQESRKVAMTLL 517
Cdd:COG5807 210 KFNFKK-LNLNDVLEDVIALLSTEAILKNIsiKYDLA-DDEPV-INGDKNQLKQVFINLIKNAIEAM--ETGGNITIKTY 284
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521099088 518 SDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:COG5807 285 VEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
348-589 |
6.58e-40 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 152.44 E-value: 6.58e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 348 IDERIRTEQALRQTQneliqaaKLAVLGQMSASISHELNNPLAAIRSFADnsrRFLANGKSER-------TDEnLARISA 420
Cdd:COG5809 251 ITERKKLEELLRKSE-------KLSVVGELAAGIAHEIRNPLTSLKGFIQ---LLKDTIDEEQktyldimLSE-LDRIES 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 421 LtermakISEQLkSFARKSSSDEKaDVQLYPIVVYAKELMQPQFKSH--YIELNIQTPLEPVWASVNpiQLEQVLINLLT 498
Cdd:COG5809 320 I------ISEFL-VLAKPQAIKYE-PKDLNTLIEEVIPLLQPQALLKnvQIELELEDDIPDILGDEN--QLKQVFINLLK 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 499 NAMQALDGQESRKVAMTLLSDsDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASvSP 578
Cdd:COG5809 390 NAIEAMPEGGNITIETKAEDD-DKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVE-SE 467
|
250
....*....|..
gi 521099088 579 LG-GARFTIHLP 589
Cdd:COG5809 468 VGkGTTFSITLP 479
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
353-589 |
1.74e-37 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 147.04 E-value: 1.74e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 353 RTEQalRQTQNELIQAAKLAVLGQMSASISHELNNPLAAIRSFAdnsrRFLANGKSER-TDENLARISALTERMAKISEQ 431
Cdd:PRK11360 371 LTER--KRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYV----QIWRQQTSDPpSQEYLSVVLREVDRLNKVIDQ 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 432 LKSFARKSSSdEKADVQLYPIVVYAKELMQP--QFKSHYIELNIQTPLEPVWASvnPIQLEQVLINLLTNAMQALdgQES 509
Cdd:PRK11360 445 LLEFSRPRES-QWQPVSLNALVEEVLQLFQTagVQARVDFETELDNELPPIWAD--PELLKQVLLNILINAVQAI--SAR 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 510 RKVAMTLLSDSDGTL-IHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHL 588
Cdd:PRK11360 520 GKIRIRTWQYSDGQVaVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
|
.
gi 521099088 589 P 589
Cdd:PRK11360 600 P 600
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
358-589 |
2.32e-35 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 139.48 E-value: 2.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 358 LRQTQNELIQAAKLAVLGQMSASISHELNNPLAAIRSFADnsrrfLANGKSERTDENLARISALTERMAKISEQLKSFAr 437
Cdd:COG5805 271 KKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQ-----LLQPGIEDKEEYFDIMLSELDRIESIISEFLALA- 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 438 KSSSDEKADVQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQAL-DGQEsrkVAMTL 516
Cdd:COG5805 345 KPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMpNGGT---ITIHT 421
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521099088 517 LSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:COG5805 422 EEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
359-589 |
7.05e-35 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 137.19 E-value: 7.05e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 359 RQTQNE----LIQAAKLAVLGQMSASISHELNNPLAAIRSFAdnsrRFLANGKSERTDEN-LARISALTERMAKISEQLK 433
Cdd:COG5808 222 RKTLLErviqEINTQKLELIGTFAASTAHEIRNPLTSIKGFI----QLLQEKYPELEDQKyFDIIQEEIQRINQIVSEFL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 434 SFARKSSSDEKADvQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQALdgQESRKVA 513
Cdd:COG5808 298 VLGKPTAKKLELD-DLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAM--KEGGKLT 374
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521099088 514 MTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:COG5808 375 ISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLP 450
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
313-589 |
5.42e-33 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 132.60 E-value: 5.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 313 HHRQVRQRQIEQLQVEAKQKLEFLVMERTAKLHAEIDERIRTEQALRQTQNELIQAAKLavLGQMSASISHELNNPLAAI 392
Cdd:COG4251 223 GGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEE--LEQFAYVASHDLREPLRKI 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 393 RSFADNSRRFLANGKSERTDENLARISALTERMAKISEQLKSFAR-KSSSDEKADVQLYPIVVYAKELMQPQFKSHYIEL 471
Cdd:COG4251 301 SGFSQLLEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRvGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEI 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 472 NIQtPLEPVWAsvNPIQLEQVLINLLTNAMQALDGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFT--- 548
Cdd:COG4251 381 EVG-PLPTVRG--DPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhs 457
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 521099088 549 -TKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:COG4251 458 rDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
350-589 |
1.26e-32 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 129.99 E-value: 1.26e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 350 ERIRTEQALRQtqnELIQAAKLAVLGQMSASISHELNNPLAAIRSFADnsrrfLANGKSErTDENL---ARIsALTE--R 424
Cdd:COG5806 180 ENLIENILLRK---ELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQ-----LLQEPEL-SDEKRkqyIRI-ALEEldR 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 425 M-AKISEQLkSFAR-KSSSDEKADVQLypIVVYAKELMQPQFKSHYIELNIQTPlEPVWASVNPIQLEQVLINLLTNAMQ 502
Cdd:COG5806 250 AeAIITDYL-TFAKpQPEKLEKIDVSE--ELEHVIDVLSPYANMNNVEIQTELE-PGLYIEGDRQKLQQCLINIIKNGIE 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 503 ALdgQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASvSPLG-G 581
Cdd:COG5806 326 AM--PNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVE-SEVGkG 402
|
....*...
gi 521099088 582 ARFTIHLP 589
Cdd:COG5806 403 TTFTITLP 410
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
303-590 |
1.32e-32 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 133.65 E-value: 1.32e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 303 AIVYLAILLAHHRQVR-------QRQIEQLQVEAKqklEFLVMERTAKLHAEIDERIRTEQALRQTQNELIQAAKLAVLG 375
Cdd:PRK13837 375 RGPALWACLAFKSGDRivallglGRQRYGLRPPAG---ELQLLELALDCLAHAIERRRLETERDALERRLEHARRLEAVG 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 376 QMSASISHELNNPLAAIRSFADNSRRFLANGKseRTDENLARISALTERMAKISEQLKSFARKSSSDEKAdVQLYPIVVY 455
Cdd:PRK13837 452 TLASGIAHNFNNILGAILGYAEMALNKLARHS--RAARYIDEIISAGARARLIIDQILAFGRKGERNTKP-FDLSELVTE 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 456 AKELMQPQFKSHyIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQALDG------QESRKVAMTLLSDSDGTL----- 524
Cdd:PRK13837 529 IAPLLRVSLPPG-VELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGagrvdiSLSRAKLRAPKVLSHGVLppgry 607
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521099088 525 --IHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLPP 590
Cdd:PRK13837 608 vlLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
485-590 |
8.99e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 110.43 E-value: 8.99e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 485 NPIQLEQVLINLLTNAMQAldGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQN-----GLGLGLS 559
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKY--TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 521099088 560 ISQQIIQSMNGDLTASVSPLGGARFTIHLPP 590
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
485-589 |
1.41e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 103.99 E-value: 1.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 485 NPIQLEQVLINLLTNAMQALDGQESRKVAmtlLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFT---TKQNGLGLGLSIS 561
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVT---LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*...
gi 521099088 562 QQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-589 |
1.41e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 104.02 E-value: 1.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALD--GQESRKVAMTLLSDSDGTL-IHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQII 565
Cdd:cd16920 1 IQQVLINLVRNGIEAMSegGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 521099088 566 QSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
353-589 |
3.14e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 112.19 E-value: 3.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 353 RTEQALRQTQNELIQAAKLAVLGQMSASISHELNNPLAAIRSFAdnsRRFLANGKSERTDENLARISAL-TERMAKISEQ 431
Cdd:PRK10364 216 RYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLA---KYFAERAPAGGEAHQLAQVMAKeADRLNRVVSE 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 432 LKSFARKSSSDEKAdVQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQALDGQESRK 511
Cdd:PRK10364 293 LLELVKPTHLALQA-VDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVIS 371
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521099088 512 VAMTllSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK10364 372 VTAS--ESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-589 |
1.23e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 101.34 E-value: 1.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 486 PIQLEQVLINLLTNAMQALDGqESRKVAMTLLSDsDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQ--NGLGLGLSISQQ 563
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEG-RGRITIRTWAHV-DQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 521099088 564 IIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
351-589 |
2.28e-24 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 105.32 E-value: 2.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 351 RIRTEqaLRQTQNELIQAAKLAvlgQMSASISHELNNPLAAIRSFADNsrrflangksERTDENLARISALTERMakisE 430
Cdd:COG3290 171 RDRTE--LERLEEELEGVKELA---EALRAQRHDFRNHLHTISGLLQL----------GEYDEALEYIDEISEEL----Q 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 431 QLKSFARKSSSDEKADVQLYPIVVYAKELmqpqfkshYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQALDGQES- 509
Cdd:COG3290 232 ELIDSLLSRIGNPVLAALLLGKAARARER--------GIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVEKLPEe 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 510 -RKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTK-QNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIH 587
Cdd:COG3290 304 eRRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVR 383
|
..
gi 521099088 588 LP 589
Cdd:COG3290 384 LP 385
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-588 |
5.48e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 93.68 E-value: 5.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQ--NGLGLGLSISQQIIQ 566
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|..
gi 521099088 567 SMNGDLTASVSPLGGARFTIHL 588
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTFDL 102
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
347-561 |
2.88e-22 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 100.90 E-value: 2.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 347 EIDERIRTEQALRQTQneliqaaKLAVLGQMSASISHELNNPLAAIRSFADNSRRFLANGKS--ERTDENLARISALTER 424
Cdd:PRK13557 143 DVSRRRDAEDALRQAQ-------KMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDAdrGRMARSVENIRAAAER 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 425 MAKISEQLKSFARKSSSDEKAdVQLYPIVVYAKELMQPQFKSHyieLNIQTPLEP-VWAS-VNPIQLEQVLINLLTNAMQ 502
Cdd:PRK13557 216 AATLTQQLLAFARKQRLEGRV-LNLNGLVSGMGELAERTLGDA---VTIETDLAPdLWNCrIDPTQAEVALLNVLINARD 291
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521099088 503 ALDGQESRKVAM--TLLSDSDGTL-----------IHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSIS 561
Cdd:PRK13557 292 AMPEGGRVTIRTrnVEIEDEDLAMyhglppgryvsIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLS 363
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
363-594 |
5.01e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 95.83 E-value: 5.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 363 NELIQAAKlavlgQMSASISHELNNPLAAIR---SFADNsrrfLANGKSERTDENLARISALTERM--------AKISEQ 431
Cdd:PRK10604 206 NALIASKK-----QLIDGIAHELRTPLVRLRyrlEMSDN----LSAAESQALNRDIGQLEALIEELltyarldrPQNELH 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 432 LKSFARKSSSDEK-ADVQLypivvyakelMQPQfkshyIELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQALDGQesr 510
Cdd:PRK10604 277 LSEPDLPAWLSTHlADIQA----------VTPE-----KTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSR--- 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 511 kVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFF------TTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARF 584
Cdd:PRK10604 339 -VRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARF 417
|
250
....*....|.
gi 521099088 585 TIHLP-PLTAP 594
Cdd:PRK10604 418 SFSWPvWHNLP 428
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
379-589 |
6.73e-21 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 95.86 E-value: 6.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 379 ASISHELNNPLAAIR----SFADNSRRFlangkserTDENLARISALTERMAKISEQLKSFarkSSSDE------KADVQ 448
Cdd:PRK10549 245 ADISHELRTPLAVLRgeleAIQDGVRKF--------TPESVASLQAEVGTLTKLVDDLHQL---SLSDEgalayrKTPVD 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 449 LYPIVVYAKELMQPQFKSHYIELNIQTPLE-PVWAsvNPIQLEQVLINLLTNAMQALDgqESRKVAMTLLSDSDGTLIHV 527
Cdd:PRK10549 314 LVPLLEVAGGAFRERFASRGLTLQLSLPDSaTVFG--DPDRLMQLFNNLLENSLRYTD--SGGSLHISAEQRDKTLRLTF 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521099088 528 DDNGPGIGQDKMAHLFEPFFTTKQN------GLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK10549 390 ADSAPGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-589 |
8.00e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 87.49 E-value: 8.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDgqesRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFF------TTKQNGLGLGLSISQ 562
Cdd:cd16939 1 MARALDNLLRNALRYAH----RTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*..
gi 521099088 563 QIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16939 77 RVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
489-589 |
1.14e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 81.77 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALD-GQESRKVAMTLLSDSDGTL-IHVDDNGPGIGQDKMAHLFEPF------FTTKQNGLGLGLSI 560
Cdd:cd16922 1 LRQILLNLLGNAIKFTEeGEVTLRVSLEEEEEDGVQLrFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 521099088 561 SQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-589 |
1.34e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 81.29 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDGQE---------SRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLS 559
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtrtQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 521099088 560 ISQQIIQSMNGDLTASVSPlGGARFTIHLP 589
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-589 |
2.58e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 80.58 E-value: 2.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 485 NPIQLEQVLINLLTNAMQALDgqESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQN------GLGLGL 558
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTD--TGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 521099088 559 SISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-589 |
4.45e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 79.89 E-value: 4.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 488 QLEQVLINLLTNAMQALDGQESRK--VAMTLLSDSDGTL-IHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQI 564
Cdd:cd16944 4 QISQVLTNILKNAAEAIEGRPSDVgeVRIRVEADQDGRIvLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKI 83
|
90 100
....*....|....*....|....*
gi 521099088 565 IQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16944 84 MEEHGGRISLSNREAGGACIRIILP 108
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
339-589 |
2.21e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 84.98 E-value: 2.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 339 ERTAKLHAEIDERIRT-EQALRQTQ---NELIQAAKLAVLGQMS--ASISHELNNPLAAIR-SFADNSRRflaNGKSERt 411
Cdd:PRK09470 202 DEVAQGNLRQHPELETgPQEFRQAGasfNQMVTALERMMTSQQRllSDISHELRTPLTRLQlATALLRRR---QGESKE- 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 412 denLARISALTERMAK-ISE-------QLKSfaRKSSSDEKADVQLYPIVVYAK---ELMQpqfkshyIELNIQTPLEPV 480
Cdd:PRK09470 278 ---LERIETEAQRLDSmINDllvlsrnQQKN--HLERETFKANSLWSEVLEDAKfeaEQMG-------KSLTVSAPPGPW 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 481 WASVNPIQLEQVLINLLTNAMQAldGQESRKVAMTLlsDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTT------KQNGL 554
Cdd:PRK09470 346 PINGNPNALASALENIVRNALRY--SHTKIEVAFSV--DKDGLTITVDDDGPGVPEEEREQIFRPFYRVdeardrESGGT 421
|
250 260 270
....*....|....*....|....*....|....*
gi 521099088 555 GLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK09470 422 GLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
377-589 |
1.22e-16 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 82.65 E-value: 1.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 377 MSASISHELNNPLAAIRsfadnsrrfLANGKSERTDENLAR-ISALTERMAKISEQLKSFARkssSDEKADVQLYPIVVY 455
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIR---------LATEMMSEEDGYLAEsINKDIEECNAIIEQFIDYLR---TGQEMPMEMADLNAL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 456 AKELMQPQfkSHY---IELNIQTPLEPVWAsvNPIQLEQVLINLLTNAMQALDGQesrkVAMTLLSDSDGTLIHVDDNGP 532
Cdd:PRK09467 300 LGEVIAAE--SGYereIETALQPGPIEVPM--NPIAIKRALANLVVNAARYGNGW----IKVSSGTEGKRAWFQVEDDGP 371
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521099088 533 GIGQDKMAHLFEPFftTKQN------GLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK09467 372 GIPPEQLKHLFQPF--TRGDsargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
380-589 |
1.58e-16 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 82.58 E-value: 1.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 380 SISHELNNPLAAIRSFA---------DNSRRFLANGKSERtdenlARISALTERMAKIS--EQLKSFarksssDEKADVQ 448
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAellqedpppEDRARFTGNILTQS-----ARLQQLIDRLLELArlEQRQEL------EVLEPVA 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 449 LYPIVVYAKELMQPQFKSHYIELNIQTPlePVWASVNPIQLEQVLINLLTNAmqaLD--GQESRkVAMTLLSDSDGTLIH 526
Cdd:PRK11100 331 LAALLEELVEAREAQAAAKGITLRLRPD--DARVLGDPFLLRQALGNLLDNA---IDfsPEGGT-ITLSAEVDGEQVALS 404
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521099088 527 VDDNGPGIGQDKMAHLFEPFFT-----TKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK11100 405 VEDQGPGIPDYALPRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
324-597 |
7.74e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 81.24 E-value: 7.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 324 QLQVEAKQKLeflvMERTAKLHAEIDERI----RTEQALRQTQNELIQAAKLAVLgqmsasiSHELNNPLAAIrsfadns 399
Cdd:PRK10490 621 QLMIPEQQRL----LETFTLLIANALERLtltaSEEQARLASEREQLRNALLAAL-------SHDLRTPLTVL------- 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 400 rrFlanGKSERTDENLA-RISALTERMAKISEQ----------LKSFARKSSSD---EKADVQLYPIVVYAKELMQPQFK 465
Cdd:PRK10490 683 --F---GQAEILTLDLAsEGSPHARQASEIRQQvlnttrlvnnLLDMARIQSGGfnlRKEWLTLEEVVGSALQMLEPGLS 757
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 466 SHYIELNIQTPLEPVwaSVNPIQLEQVLINLLTNAMQALDGQESRKVAMTLLSDSdgtlIHVD--DNGPGIGQDKMAHLF 543
Cdd:PRK10490 758 GHPINLSLPEPLTLI--HVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGER----LQLDvwDNGPGIPPGQEQLIF 831
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 544 EPFftTKQN------GLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLPPLTAPATE 597
Cdd:PRK10490 832 DKF--ARGNkesaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETPPELE 889
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
330-589 |
8.66e-16 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 81.10 E-value: 8.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 330 KQKLEFLVMERTAKLHAEIDERirteqalRQTQNELIQA--AKLAVLgqmsASISHELNNPLAAIRSFAdnsrRFLA-NG 406
Cdd:PRK11466 409 REQLAAQVKARTAELQELVIEH-------RQARAEAEKAsqAKSAFL----AAMSHEIRTPLYGILGTA----QLLAdNP 473
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 407 KSERTDENLARISALTERMAKISEQLKSFA-------RKSSSDEKADVQlyPIVVYAKELMQPQFKSHYIELNIQ-TPLE 478
Cdd:PRK11466 474 ALNAQRDDLRAITDSGESLLTILNDILDYSaieaggkNVSVSDEPFEPR--PLLESTLQLMSGRVKGRPIRLATDiADDL 551
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 479 PVWASVNPIQLEQVLINLLTNAMQALDgqesrKVAMTLLSDSDGT--LIHVDDNGPGIGQDKMAHLFEPF--FTTKQNGL 554
Cdd:PRK11466 552 PTALMGDPRRIRQVITNLLSNALRFTD-----EGSIVLRSRTDGEqwLVEVEDSGCGIDPAKLAEIFQPFvqVSGKRGGT 626
|
250 260 270
....*....|....*....|....*....|....*
gi 521099088 555 GLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK11466 627 GLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
349-589 |
1.17e-15 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 79.95 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 349 DERIRTEQALrQTQNELIQAAKLAvlgqMSASIsHELNNPL----AAIRSFadnSRRFLANGksertdeNLARISALTER 424
Cdd:TIGR02938 257 RARLSALQAL-MAEEERLEAIRET----LSAAI-HRLQGPMnlisAAISVL---QRRGDDAG-------NPASAAMLQQA 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 425 MAKISEQLKSFAR---KSSSDEKADVQLYPIVVYAKELMQPQFKSHYIELNIQTPLEPVWASVNPIQLEQVLINLLTNAM 501
Cdd:TIGR02938 321 LSAGREHMEALRQvipQSPQEIVVPVNLNQILRDVITLSTPRLLAAGIVVDWQPAATLPAILGRELQLRSLFKALVDNAI 400
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 502 QALDGQESRKVAMTLLSDSDGTLIHVD--DNGPGIGQDKMAHLFEPFFTTK---QNGLGLGLSISQQIIQSMNGDLTASV 576
Cdd:TIGR02938 401 EAMNIKGWKRRELSITTALNGDLIVVSilDSGPGIPQDLRYKVFEPFFTTKggsRKHIGMGLSVAQEIVADHGGIIDLDD 480
|
250
....*....|...
gi 521099088 577 SPLGGARFTIHLP 589
Cdd:TIGR02938 481 DYSEGCRIIVEFR 493
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-589 |
3.08e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 71.55 E-value: 3.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 495 NLLTNAMQAL--DGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTK-QNGLGLGLSISQQIIQSMNGD 571
Cdd:cd16915 7 NLIDNALDALaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKgQGERGIGLALVRQSVERLGGS 86
|
90
....*....|....*...
gi 521099088 572 LTASVSPLGGARFTIHLP 589
Cdd:cd16915 87 ITVESEPGGGTTFSIRIP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
469-588 |
3.09e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 72.55 E-value: 3.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 469 IELNIqtPLEPVWASVNPIQLEQVLINLLTNAMQAldGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFT 548
Cdd:cd16947 3 VEINI--PDRPIYANANTEALQRILKNLISNAIKY--GSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYT 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 521099088 549 TKQN------GLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHL 588
Cdd:cd16947 79 LEDSrnsakqGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
346-589 |
3.31e-15 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 77.43 E-value: 3.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 346 AEIDERIRTEQALRQTQNEliQAAKLAVLGqmsasISHELNNPLAAIRSFADNSRRFLANgksertdenlariSALTERM 425
Cdd:PRK11073 109 APMDNQRRLSQEQLQHAQQ--VAARDLVRG-----LAHEIKNPLGGLRGAAQLLSKALPD-------------PALTEYT 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 426 AKISEQlksfarksssdekADvQLYPIVvyaKELMQPQFKSHYIELNIQTPLEPVWASV--------------------- 484
Cdd:PRK11073 169 KVIIEQ-------------AD-RLRNLV---DRLLGPQRPGTHVTESIHKVAERVVQLVslelpdnvrlirdydpslpel 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 485 --NPIQLEQVLINLLTNAMQALdGQESRKVAMTLLSDSDGTL----------IHVDDNGPGIGQDKMAHLFEPFFTTKQN 552
Cdd:PRK11073 232 ahDPDQIEQVLLNIVRNALQAL-GPEGGTITLRTRTAFQLTLhgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGREG 310
|
250 260 270
....*....|....*....|....*....|....*..
gi 521099088 553 GLGLGLSISQQIIQSMNGDLTASVSPlGGARFTIHLP 589
Cdd:PRK11073 311 GTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLP 346
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-589 |
8.40e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 70.43 E-value: 8.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDgqesRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFF------TTKQNGLGLGLSISQ 562
Cdd:cd16949 1 LARALENVLRNALRYSP----SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*..
gi 521099088 563 QIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
492-589 |
3.07e-14 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 75.72 E-value: 3.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 492 VLINLLTNAMQALDGQESRKVAMTLlSDSDGTL-IHVDDNGPGIGQDKMAHLFEPFFTTKQNGLGLGLSISQQIIQSMNG 570
Cdd:PRK11086 437 ILGNLIENALEAVGGEEGGEISVSL-HYRNGWLhCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGG 515
|
90
....*....|....*....
gi 521099088 571 DLTASVSPLGGARFTIHLP 589
Cdd:PRK11086 516 SIAVESEPGVGTQFFVQIP 534
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
351-589 |
1.23e-13 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 74.24 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 351 RIRTEQALRQTQNELIQA--AKLAVLgqmsASISHELNNPLAAI---------RSFADNSRRFLA--NGKSERTdenLAR 417
Cdd:PRK10841 426 RVKMEESLQEMAQAAEQAsqSKSMFL----ATVSHELRTPLYGIignldllqtKELPKGVDRLVTamNNSSSLL---LKI 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 418 ISALTErMAKI-SEQLKSFARKSSSDEkadVQLY------PIVVyAKELMQPQFkshyIELNIqtplePVWASVNPIQLE 490
Cdd:PRK10841 499 ISDILD-FSKIeSEQLKIEPREFSPRE---VINHitanylPLVV-KKRLGLYCF----IEPDV-----PVALNGDPMRLQ 564
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 491 QVLINLLTNAMQALDgqeSRKVAMTLLSDSDGTLIHVDDNGPGIgQDKMAH-LFEPFFTTKQN------GLGLGLSISQQ 563
Cdd:PRK10841 565 QVISNLLSNAIKFTD---TGCIVLHVRVDGDYLSFRVRDTGVGI-PAKEVVrLFDPFFQVGTGvqrnfqGTGLGLAICEK 640
|
250 260
....*....|....*....|....*.
gi 521099088 564 IIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK10841 641 LINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-589 |
1.37e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 67.21 E-value: 1.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMqALDGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQNGL------GLGLSISQ 562
Cdd:cd16953 1 LGQVLRNLIGNAI-SFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEafgqhsGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 521099088 563 QIIQSMNGDLTASV----SPLGGARFTIHLP 589
Cdd:cd16953 80 QIIEAHGGISVAENhnqpGQVIGARFTVQLP 110
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-586 |
1.66e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 67.66 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDGQesrkVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFE--PFFTTKQNGLGLGLSISQQIIQ 566
Cdd:cd16954 38 LMELLGNLLDNACKWCLEF----VEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVE 113
|
90 100
....*....|....*....|
gi 521099088 567 SMNGDLTASVSPLGGARFTI 586
Cdd:cd16954 114 QYGGELSLSDSPLGGARFEV 133
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
258-595 |
1.55e-12 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 70.83 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 258 GWIK-GDFIVSSRQLSMPDLTIRVLSPKMNVFWDV---------FGFVMILTMVFAI-----VYLAILLAH--------- 313
Cdd:PRK15347 257 GWQQiPDYLVLRTQLKGPGWQQVTLYPRRNLANEAlkpalqqlpFALLILVLLTSVLflllrRYLAKPLWRfvdiinktg 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 314 -----HRQVRQRQIEQLQV-EAKQKLEFLVMERTAKLHAEIDERIRtEQALRQTQNELIQAAKLAVLgqmsASISHELNN 387
Cdd:PRK15347 337 paalePRLPENRLDELGSIaKAYNQLLDTLNEQYDTLENKVAERTQ-ALAEAKQRAEQANKRKSEHL----TTISHEIRT 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 388 PLAAI--------RSFADNSRRFLANGKSERTDENLARISALTErmakiseqlksFARKSSSDEKADVQLYPIVVYAKEL 459
Cdd:PRK15347 412 PLNGVlgalellqNTPLTAEQMDLADTARQCTLSLLAIINNLLD-----------FSRIESGQMTLSLEETALLPLLDQA 480
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 460 M---QPQFKSHYIEL----NIQTPLEpvwASVNPIQLEQVLINLLTNAMQAldgQESRKVAMTLLSDSDGTLIHVDDNGP 532
Cdd:PRK15347 481 MltiQGPAQSKSLTLrtfvGAHVPLY---LHLDSLRLRQILVNLLGNAVKF---TETGGIRLRVKRHEQQLCFTVEDTGC 554
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521099088 533 GIGQDKMAHLFEPFFTTKQN--GLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLpPLTAPA 595
Cdd:PRK15347 555 GIDIQQQQQIFTPFYQADTHsqGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL-PLNEYA 618
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
383-566 |
2.83e-12 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 68.91 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 383 HELNNPLAAIRSFADNSRrfLANGKSERTDENLARISALTERMAKISEQLKSFARKSSSDEKADVQLYPIvvyaKELMQP 462
Cdd:PRK10337 246 HELRSPLAALKVQTEVAQ--LSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPL----EDLLQS 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 463 QFKSHY-------IELNIQTPLEPVWASVNPIQLEQVLINLLTNAMQAldGQESRKVAMTLLSDSdgtlIHVDDNGPGIG 535
Cdd:PRK10337 320 AVMDIYhtaqqagIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRY--SPQGSVVDVTLNARN----FTVRDNGPGVT 393
|
170 180 190
....*....|....*....|....*....|....
gi 521099088 536 QDKMAHLFEPFFT---TKQNGLGLGLSISQQIIQ 566
Cdd:PRK10337 394 PEALARIGERFYRppgQEATGSGLGLSIVRRIAK 427
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
485-589 |
4.87e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 62.90 E-value: 4.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 485 NPIQLEQVLINLLTNAMQAL-DGQESRkvAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPF------FTTKQNGLGLG 557
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTpDGGRIR--CILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 521099088 558 LSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16925 79 LSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
489-589 |
5.21e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 62.78 E-value: 5.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQAL-DGQESRKVAMTLLSDSDGTLIH------------VDDNGPGIGQDKMAHLFEPFFTTKQ--NG 553
Cdd:cd16919 1 LELAILNLAVNARDAMpEGGRLTIETSNQRVDADYALNYrdlipgnyvcleVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 521099088 554 LGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
477-588 |
1.33e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 61.65 E-value: 1.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 477 LEPVWASVNPIQLEQVLINLLTNAMQaLDGQESRkvAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFF-TTKQN--G 553
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVR-YSPQGSR--VEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYrSDGQNygG 78
|
90 100 110
....*....|....*....|....*....|....*
gi 521099088 554 LGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHL 588
Cdd:cd16940 79 SGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
460-589 |
2.46e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 66.89 E-value: 2.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 460 MQPQFKSHYIELNIQTPLePVWASVNPIQLEQVLINLLTNAMQALdgQESrKVAMTLLSDSDGTL-IHVDDNGPGIGQDK 538
Cdd:PRK11091 371 LQAEQKGLRFDLEPLLPL-PHKVITDGTRLRQILWNLISNAVKFT--QQG-GVTVRVRYEEGDMLtFEVEDSGIGIPEDE 446
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 521099088 539 MAHLFEPFFTTKQN-------GLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK11091 447 LDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
356-589 |
2.62e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 66.68 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 356 QALRQTQNELIQAAklAVLGQMSASISHELNNPLAAIRSFADnsrrfLANGKSERTDEnlaRISALTERMAKISEQLKSF 435
Cdd:PRK09959 696 HALEVERNKAINAT--VAKSQFLATMSHEIRTPISSIMGFLE-----LLSGSGLSKEQ---RVEAISLAYATGQSLLGLI 765
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 436 ARKSSSD--EKADVQLYPIVVYAKELMQPQ-------FKSHYIELNIQTPL-EPVWASVNPIQLEQVLINLLTNAMQ-AL 504
Cdd:PRK09959 766 GEILDVDkiESGNYQLQPQWVDIPTLVQNTchsfgaiAASKSIALSCSSTFpDHYLVKIDPQAFKQVLSNLLSNALKfTT 845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 505 DGQESRKVAMTLLSDSDGTL-IHVDDNGPGIGQDKMAHLFEPFFTT----KQNGLGLGLSISQQIIQSMNGDLTASVSPL 579
Cdd:PRK09959 846 EGAVKITTSLGHIDDNHAVIkMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSLESHPG 925
|
250
....*....|
gi 521099088 580 GGARFTIHLP 589
Cdd:PRK09959 926 IGTTFTITIP 935
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
358-589 |
3.02e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 65.36 E-value: 3.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 358 LRQTQNELIQaaKLAVLGQMSASISHELNNPLA----AIRSFADNSRRFLANGKSERTDENLARISALTERMAKISEQLK 433
Cdd:PRK09303 137 LRQENETLLE--QLKFKDRVLAMLAHDLRTPLTaaslALETLELGQIDEDTELKPALIEQLQDQARRQLEEIERLITDLL 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 434 SFARKSSSD---EKADVQLYPIVVYAKELMQPQFKSHYIELN--IQTPLEPVWAsvNPIQLEQVLINLLTNAMQALDGQE 508
Cdd:PRK09303 215 EVGRTRWEAlrfNPQKLDLGSLCQEVILELEKRWLAKSLEIQtdIPSDLPSVYA--DQERIRQVLLNLLDNAIKYTPEGG 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 509 SRKVAMtLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTKQN----GLGLGLSISQQIIQSMNGDLTASVSPLGGARF 584
Cdd:PRK09303 293 TITLSM-LHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDegteGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCF 371
|
....*
gi 521099088 585 TIHLP 589
Cdd:PRK09303 372 HFTLP 376
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-589 |
3.35e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 60.16 E-value: 3.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDGQESRKvamtllSDSDG--TLIHVDDNGPGIGQDKMAHLFEPFFTTKQ----NGLGLGLSISQ 562
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVS------SDGEGnrTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQ 74
|
90 100
....*....|....*....|....*..
gi 521099088 563 QIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16950 75 RISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
273-583 |
7.82e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 64.65 E-value: 7.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 273 MPDLTIRVLSP------KMNVFWDVFGFVMI--LTMVFAIVYLAillAH---------HRQVRQ---RQIEQLQVEAKQK 332
Cdd:PRK10815 168 LPKLTIVVVDTipqelqRSYMVWSWFSYVLLanLLLVIPLLWLA---AWwslrpiealAKQVREleeGEREQLDPNPPRE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 333 LEFLVMERTAKLHaeiDERIRTEQaLRQTQNELiqaaklavlgqmsasiSHELNNPLAAIRSfadnSRRFLANGKsERTD 412
Cdd:PRK10815 245 LTSLVRNLNRLLK---NERERYTK-YRTTLTDL----------------THSLKTPLAVLQS----TLRSLRSGK-QMSV 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 413 ENLARIsaLTERMAKISEQLKSFARKSSSDEKADV---QLYPIV------------VYakelmqpQFKSHYIELNIqtPL 477
Cdd:PRK10815 300 EQAEPI--MLEQISRISQQIGYYLHRASMRSEHNLlsrELHSVAplldnltsalnkVY-------QRKGVNITLDI--SP 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 478 EPVWASVNPIQLEqVLINLLTNAMQ-ALDgqesrKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFE--PFFTTKQNGL 554
Cdd:PRK10815 369 EITFVGEKNDFME-VMGNVLDNACKyCLE-----FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDrgQRADTLRPGQ 442
|
330 340
....*....|....*....|....*....
gi 521099088 555 GLGLSISQQIIQSMNGDLTASVSPLGGAR 583
Cdd:PRK10815 443 GLGLSVAREITEQYEGKISAGDSPLGGAR 471
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
371-437 |
8.43e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 57.61 E-value: 8.43e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521099088 371 LAVLGQMSASISHELNNPLAAIRSFADNSRRFLANgkSERTDENLARISALTERMAKISEQLKSFAR 437
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLD--DEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-581 |
1.71e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 58.24 E-value: 1.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 485 NPIQLEQVLINLLTNAMQAldGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFT-----TKQNGLGLGLS 559
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDF--SPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLA 78
|
90 100
....*....|....*....|..
gi 521099088 560 ISQQIIQSMNGDLTASVSPLGG 581
Cdd:cd16945 79 FVQEVAQLHGGRITLRNRPDGV 100
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-589 |
1.25e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 55.80 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPF----FTTKQNGLGLGLSISQQI 564
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrlhSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 521099088 565 IQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
376-573 |
2.99e-09 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 59.21 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 376 QMSASISHELNNPLAAIRSfadnSRRFLANGKSERTDENLARIsaltERMAKISEQLKSFARKSSSDEKAdvqLYPIVVY 455
Cdd:PRK10755 139 LFTADVAHELRTPLAGIRL----HLELLEKQHHIDVAPLIARL----DQMMHTVEQLLQLARAGQSFSSG---HYQTVKL 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 456 AKELMQPQfkshYIELN---------IQTPLEPVWASV--NPIQLEQVLINLLTNAMQALDgqESRKVAMTLLSDSDGTL 524
Cdd:PRK10755 208 LEDVILPS----QDELSemleqrqqtLLLPESAADITVqgDATLLRLLLRNLVENAHRYSP--EGSTITIKLSQEDGGAV 281
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 521099088 525 IHVDDNGPGIGQDKMAHLFEPF--FTTKQNGLGLGLSISQQIIQSMNGDLT 573
Cdd:PRK10755 282 LAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFF 332
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
374-440 |
1.49e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 51.44 E-value: 1.49e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521099088 374 LGQMSASISHELNNPLAAIRSFADNSRRFLANgksERTDENLARISALTERMAKISEQLKSFARKSS 440
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLD---EEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
374-440 |
9.65e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.10 E-value: 9.65e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521099088 374 LGQMSASISHELNNPLAAIRSFADnsrRFLANGKSERTDENLARISALTERMAKISEQLKSFARKSS 440
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLE---LLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-590 |
1.30e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 50.28 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQAldGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFF------TTKQNGLGLGLSISQ 562
Cdd:cd16952 1 LRSAFSNLVSNAVKY--TPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVK 78
|
90 100
....*....|....*....|....*...
gi 521099088 563 QIIQSMNGDLTASVSPLGGARFTIHLPP 590
Cdd:cd16952 79 HVMSRHDARLLIASELGKGSRFTCLFPS 106
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
486-589 |
2.36e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 54.08 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 486 PIQLEQVLINLLTNAMQALD-GQESRKVAMTLLSDSDGTL-IHVDDNGPGIGQDKMAHLFEPF------FTTKQNGLGLG 557
Cdd:PRK11107 406 PLRLQQIITNLVGNAIKFTEsGNIDILVELRALSNTKVQLeVQIRDTGIGISERQQSQLFQAFrqadasISRRHGGTGLG 485
|
90 100 110
....*....|....*....|....*....|..
gi 521099088 558 LSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK11107 486 LVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
379-595 |
6.19e-07 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 51.93 E-value: 6.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 379 ASISHELNNPLAAIRSFADNSrrflangkSERTDENLARISAL------TERMAKISEQLKSFARKSSS-----DEKADV 447
Cdd:PRK11006 209 ANVSHELRTPLTVLQGYLEMM--------QDQPLEGALREKALhtmreqTQRMEGLVKQLLTLSKIEAAptidlNEKVDV 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 448 QLYpIVVYAKELMQPQFKSHYIELNIQTPLEpVWAsvNPIQLEQVLINLLTNAMQALdgQESRKVAMTLLSDSDGTLIHV 527
Cdd:PRK11006 281 PMM-LRVLEREAQTLSQGKHTITFEVDNSLK-VFG--NEDQLRSAISNLVYNAVNHT--PEGTHITVRWQRVPQGAEFSV 354
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521099088 528 DDNGPGIGQDKMAHLFEPFF------TTKQNGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLPP-LTAPA 595
Cdd:PRK11006 355 EDNGPGIAPEHIPRLTERFYrvdkarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPErLIAKN 429
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-586 |
9.95e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 47.46 E-value: 9.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQAldGQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFT-----TKQNGLGLGLSISQQ 563
Cdd:cd16975 5 LSRALINIISNACQY--APEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRddtsrRSGGHYGMGLYIAKN 82
|
90 100
....*....|....*....|...
gi 521099088 564 IIQSMNGDLTASVSPLGGARFTI 586
Cdd:cd16975 83 LVEKHGGSLIIENSQKGGAEVTV 105
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
141-589 |
8.22e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 48.48 E-value: 8.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 141 DSQYFALGSTSGQRGYYYAYPVVYAAEILGVVVVKMDLSAIEENWQSQSSYFVATDTNQVVFMSSQPSWLFKSVGNLSDT 220
Cdd:COG2972 2 SKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 221 TRDQIRSSLQYLDKPIASLGLTGDFSAQETEWFNHRMGWIKGDFIVSSRQLSMPDLTIRVLSPKMNVFWDV-----FGFV 295
Cdd:COG2972 82 ILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLfslrrLILL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 296 MILTMVFAIVYLAILLAHHRQVRQRQIEQ----------LQVEAKQKLEFLVMERT-----AKLHAEIDERIRTEQALRQ 360
Cdd:COG2972 162 IILLLLLLALLLSYLLSRSITRPIKRLKKamkkvekgdlVRLEVSGNDEIGILARSfnemvERIKELIEEVYELELEKKE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 361 TQNELIQAaklavlgQMSasiSHELNNPLAAIRSFADNsrrflangksertdENLARISALTERMAKiseqlksFARKSS 440
Cdd:COG2972 242 AELKALQA-------QIN---PHFLFNTLNSIRWLAEL--------------EDPEEAEEMLEALSK-------LLRYSL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 441 SDEKADVQLypivvyAKELMqpqfkshYIE--LNIQ-----TPLEPVWaSVNPiQLEQVLINLLT------NAMQA--LD 505
Cdd:COG2972 291 SKGDELVTL------EEELE-------LIKsyLEIQklrfgDRLEVEI-EIDE-ELLDLLIPKLIlqplveNAIEHgiEP 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 506 GQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPfFTTKQNGLGLGLSISQQIIQSMNGD---LTASVSPLGGA 582
Cdd:COG2972 356 KEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGT 434
|
....*..
gi 521099088 583 RFTIHLP 589
Cdd:COG2972 435 TVTIRIP 441
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-589 |
5.25e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 42.66 E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 496 LLTNAMQALDgqESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFFTTK-----QNGLGLGLSISQQIIQSMNG 570
Cdd:cd16948 13 IVSNALKYSK--QGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGH 90
|
90
....*....|....*....
gi 521099088 571 DLTASVSPLGGARFTIHLP 589
Cdd:cd16948 91 KIDVESEVGEGTTFTITFP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
378-589 |
5.47e-05 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 45.92 E-value: 5.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 378 SASISHELNNPlaaIRSFADNSRRFLANGKSERTDENLArISALTE--RMAKISEQLKSFARKSSSdekadvQLYPIVV- 454
Cdd:PRK09835 266 SADIAHEIRTP---ITNLITQTEIALSQSRSQKELEDVL-YSNLEEltRMAKMVSDMLFLAQADNN------QLIPEKKm 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 455 --YAKELMQ--PQFKSHYIELNIQTPLE--PVWASVNPIQLEQVLINLLTNAMQALDGQESrkVAMTLLSDSDGTLIHVD 528
Cdd:PRK09835 336 ldLADEVGKvfDFFEAWAEERGVELRFVgdPCQVAGDPLMLRRAISNLLSNALRYTPAGEA--ITVRCQEVDHQVQLVVE 413
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521099088 529 DNGPGIGQDKMAHLFEPFFTT------KQNGLGLGLSISQQIIQSMNGDLTASvSPLGGARFTIHLP 589
Cdd:PRK09835 414 NPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVT-SDARGTRFVISLP 479
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-589 |
6.36e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.77 E-value: 6.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 497 LTNAM---QAldgqesRKVAMTLLSDSDGTLIHVDDNGPGIGQDkmahlfepfftTKQNGLGLGLSISQQIIQSMNGDLT 573
Cdd:cd16917 9 LTNALkhaGA------SRVRVTLSYTADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLT 71
|
90
....*....|....*.
gi 521099088 574 ASVSPLGGARFTIHLP 589
Cdd:cd16917 72 IGSRPGGGTRVTARLP 87
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
487-572 |
8.28e-05 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 42.26 E-value: 8.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 487 IQLEQVLINLLTNAMQ---ALDGQESRKVAMTLLSDSDG-TLIHVD----DNGPGIGQDKMAHLFEPffTTKQNGLGLGL 558
Cdd:cd16932 5 IRLQQVLADFLLNAVRftpSPGGWVEIKVSPTKKQIGDGvHVIHLEfritHPGQGLPEELVQEMFEE--NQWTTQEGLGL 82
|
90
....*....|....
gi 521099088 559 SISQQIIQSMNGDL 572
Cdd:cd16932 83 SISRKLVKLMNGDV 96
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
30-278 |
1.13e-04 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 43.86 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 30 QYQSLLLDHQSQLDKFSSLITAKLDKYAHIPRLLSKDKELVDALLHPANTAQIEVTNRYleqvNDVIQAADTYLLDQYGN 109
Cdd:pfam02743 3 IKEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLESLL----RSNPGISSIYLVDADGR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 110 TLAASNWNleRSFIGRNFAWRPYFYQSIAGADSQYFALGSTSGQRGYYYAYPV------VYAAEILGVVVVKMDLSAIEE 183
Cdd:pfam02743 79 VLASSDES--PSYPGLDVSERPWYKEALKGGGGIIWVFSSPYPSSESGEPVLTiarpiyDDDGEVIGVLVADLDLDTLQE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 184 ----NWQSQSSYFVATDTNQVVFMSSQPswlfksvGNLSDTTRDQIRSSLQYLDkpiaslgltgdfsaQETEWFNHRMGW 259
Cdd:pfam02743 157 llsqIKLGEGGYVFIVDSDGRILAHPLG-------KNLRSLLAPFLGKSLADAL--------------PGSGITEIAVDL 215
|
250
....*....|....*....
gi 521099088 260 IKGDFIVSSRQLSMPDLTI 278
Cdd:pfam02743 216 DGEDYLVAYAPIPGTGWTL 234
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-576 |
4.64e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 39.68 E-value: 4.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 489 LEQVLINLLTNAMQALDgqESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKMAHLFEPFF----TTKQNGLGLGLSISQQI 564
Cdd:cd16923 1 LQRVFSNLLSNAIKYSP--ENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAI 78
|
90
....*....|..
gi 521099088 565 IQSMNGDLTASV 576
Cdd:cd16923 79 IELHGGSASAEY 90
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
469-573 |
1.26e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 39.48 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 469 IELNIQTPLEPVwasVNPIQLEQVLINLLTNAMQALD--GQESRKVAMTLLSDSDGTLIHVDDNGPGIGQDKmahlFEPF 546
Cdd:cd16935 20 FTIEIDIPILLP---ISPLDLCIIFGNLLDNAIEACAkiDKENRFIHLKIRQKKGFLIISIENSYEGELKKK----NGLF 92
|
90 100
....*....|....*....|....*...
gi 521099088 547 FTTKQ-NGLGLGLSISQQIIQSMNGDLT 573
Cdd:cd16935 93 LSTKKdKNHGIGLKSIREIVKKYNGNLS 120
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
488-589 |
2.51e-03 |
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Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 39.10 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 488 QLEQVLINLLTNAM-QALDGQESR---------KVAMTLLSDSDGTLIHVDDNGPGIGQDKM------------------ 539
Cdd:cd16916 38 KLADPLTHLLRNAVdHGIEAPEERlaagkppegTITLRAEHQGNQVVIEVSDDGRGIDREKIrekaierglitadeaatl 117
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 521099088 540 ------AHLFEPFFTTKQ-----NGLGLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:cd16916 118 sddevlNLIFAPGFSTAEqvtdvSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
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| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
484-573 |
6.49e-03 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 36.42 E-value: 6.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 484 VNPIQLEQVLINLLTNAMQALDG-QESRKVAMTLLSDSDGTLIHVD---DNGPGIGQDkmahlfepFFTTKQNG--LGLG 557
Cdd:pfam14501 1 ISDVDLCVIFGNLLDNAIEACSKiDDNRFIRLKIREKQNFLIIRIEntyEGELKFEGK--------LPSTKTKGdgHGIG 72
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90
....*....|....*.
gi 521099088 558 LSISQQIIQSMNGDLT 573
Cdd:pfam14501 73 LKSIRRIVKKYGGNLS 88
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| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
383-589 |
8.35e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 39.05 E-value: 8.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 383 HELNNPLAAIRSFADNSRRF---------LANGKSERTDENLARISALTERMAKisEQLKSFARKSSSDEKADVQLYPIV 453
Cdd:PRK15053 326 STLNAQLTQIKQYVESLRTLrhehlnwmsTLNGLLQMKEYDRVLEMVQGESQAQ--QQLIDSLREAFADRQVAGLLFGKV 403
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521099088 454 VYAKELMqpqfkshyIELNI--QTPLEPVWASVNPIQLEQVLINLLTNAMQA-LDGQESRKVAMTLLSDS-DGTLIHVDD 529
Cdd:PRK15053 404 QRARELG--------LKMVIvpGSQLSQLPPGLDSTEFAAIVGNLLDNAFEAsLRSDEGNKIVELFLSDEgDDVVIEVAD 475
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170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521099088 530 NGPGIGQDKMAHLFEPFFTTKQNGL---GLGLSISQQIIQSMNGDLTASVSPLGGARFTIHLP 589
Cdd:PRK15053 476 QGCGVPESLRDKIFEQGVSTRADEPgehGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
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