|
Name |
Accession |
Description |
Interval |
E-value |
| Na_Pro_sym |
TIGR02121 |
sodium/proline symporter; This family consists of the sodium/proline symporter (proline ... |
5-508 |
0e+00 |
|
sodium/proline symporter; This family consists of the sodium/proline symporter (proline permease) from a number of Gram-negative and Gram-positive bacteria and from the archaeal genus Methanosarcina. Using the related pantothenate permease as an outgroup, candidate sequences from Bifidobacterium longum and several from archaea are found to be outside the clade defined by known proline permeases. These sequences, scoring between 570 and -40, define the range between trusted and noise cutoff scores. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273981 Cd Length: 487 Bit Score: 564.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 5 TWFIIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLI 84
Cdd:TIGR02121 1 TEILITFGVYLIIMLLIGFYAYKKTTNLSDYVLGGRSLGPFVTALSAGASDMSGWLLMGLPGALYVTGLSELWIAIGLTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GSWCNWKWIAPRLRSYTEIARNSITIPSFLENRLRDRSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGL 164
Cdd:TIGR02121 81 GAYINWKFVAPRLRVYTEAAHNSITLPDFFENRFNDKSRLLRIISALIILVFFTIYTSSGLVAGGKLFESTFGLDYKTGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 165 AIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQTEHaygalesipaNSQWFSLFSGVS 244
Cdd:TIGR02121 161 LIGALIIVIYTFFGGFLAVSWTDFVQGLLMFFALVLVPIVALFNLGGFGETLSAVAAI----------NPHLLDMFKGAS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 245 FIAIISNLAWGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFaeGGYDITDTKNYETNFL 324
Cdd:TIGR02121 231 VIAIISLLAWGLGYFGQPHIIVRFMAIRSHKELPKARRIGMSWMILSLLGAIAVGLTGIAYF--NKNPHVELVDRETIFI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 325 DMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAALVALDPDS 404
Cdd:TIGR02121 309 VLSQILFHPWIAGILLAAILAAIMSTISSQLLVSSSALTEDFYKAFFKREASQKELVMVGRLSVLVIAIIAIILAMNPNS 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 405 AILGLVEFAWAGFGASFGPVIIAALFWRRLNVPGAVAGMAGGALVAFIWGglpqfNVMDKPFGLYEMIPGVAVNVLLLII 484
Cdd:TIGR02121 389 SILNLVGYAWAGFGAAFGPVVLFSLYWKRMTRNGALAGMIIGAVTVIVWI-----SKLGGSFGLYEIVPGFIISSIVIVV 463
|
490 500
....*....|....*....|....
gi 521254940 485 VSLRTAAPDDEVTTEFDEATRLAR 508
Cdd:TIGR02121 464 VSKLTKAPPAAVQTVFEKAKKLVK 487
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
8-488 |
0e+00 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 519.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIGSW 87
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 88 CNWKWIAPRLRSYTEIArNSITIPSFLENRLRDRSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGLAII 167
Cdd:cd11475 81 LNWLFVAKRLRRYTEKN-DSITLPDYLENRFRDKSKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 168 GVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQTEHAYGALESIPANSQWfslfsgVSFIA 247
Cdd:cd11475 160 AVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDPGLLSPFGGDLGA------GGLLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 248 IISNLAWGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFAEGGyditdTKNYETNFLDMA 327
Cdd:cd11475 234 IISLLAWGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFPDGL-----LGDPETVFPVLA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 328 SILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAALVALDPDSAIL 407
Cdd:cd11475 309 QELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIALNPPSSVF 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 408 GLVEFAWAGFGASFGPVIIAALFWRRLNVPGAVAGMAGGALVAFIWGGLPQFnvmdkPFGLYEMIPGVAVNVLLLIIVSL 487
Cdd:cd11475 389 SLVSFAWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVVVWKLLGLG-----IFGLYEIVPGFLASLLAIVVVSL 463
|
.
gi 521254940 488 R 488
Cdd:cd11475 464 L 464
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
1-503 |
8.17e-134 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 397.85 E-value: 8.17e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 1 MSDHTWFIIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAI 80
Cdd:PRK15419 1 MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 81 GLLIGSWCNWKWIAPRLRSYTEIARNSITIPSFLENRLRDRSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDY 160
Cdd:PRK15419 81 GLTLGAWINWKLVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 161 FVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDiftfqtehaygALESIPANS-QWFSL 239
Cdd:PRK15419 161 ETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGD-----------SLEVIKQKSiENVDM 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 240 FSGVSFIAIISNLAWGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFAEG-GYDITDTKN 318
Cdd:PRK15419 230 LKGLNFVAIISLMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHpAVAGAVNQN 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 319 YETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAALV 398
Cdd:PRK15419 310 AERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIAL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 399 ALDPDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNVPGAVAGMAGGALVAFIWgglPQFNVmdkpFGLYEMIPGVAVN 478
Cdd:PRK15419 390 AANPENRVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVW---KQFGW----LGLYEIIPGFIFG 462
|
490 500
....*....|....*....|....*
gi 521254940 479 VLLLIIVSLRTAAPDDEVTTEFDEA 503
Cdd:PRK15419 463 SIGIVVFSLLGKAPSAAMQKRFAEA 487
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
4-501 |
4.61e-115 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 348.73 E-value: 4.61e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 4 HTWFIIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLL 83
Cdd:COG0591 2 STLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 84 IGSWCNWKWIAPRLRSYteiarNSITIPSFLENRLrdrSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVG 163
Cdd:COG0591 82 LGALLLALFFAPRLRRL-----GALTIPEFLEKRF---GRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 164 LAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQTEhaygalesiPANSQWFSLFSGV 243
Cdd:COG0591 154 ILIGALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAALPA---------PGLLSLFPGLGFT 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 244 SFIAIIS-NLAWGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFAEGGyditdTKNYETN 322
Cdd:COG0591 225 GWLAFLGlFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLP-----LADPDLA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 323 FLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAALVALDP 402
Cdd:COG0591 300 LPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLF 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 403 DSAILGLVEFAWAGFGASFGPVIIAALFWRRLNVPGAVAGMAGGALVAFIWGGLPQFNVMdkPFGLYEMIPGVAVNVLLL 482
Cdd:COG0591 380 PSSILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGPLGP--FGWLYPILPGLLVSLLVF 457
|
490
....*....|....*....
gi 521254940 483 IIVSLRTAAPDDEVTTEFD 501
Cdd:COG0591 458 VVVSLLTKPPSEEVLEEFD 476
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
35-435 |
5.78e-84 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 266.51 E-value: 5.78e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 35 YMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIGSWCNWKWIAPRLRSYteiarNSITIPSFL 114
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNL-----GAYTMPDYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 115 ENRLRDRsHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMM 194
Cdd:pfam00474 76 RKRFGGK-RILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 195 FLALVLVPTFAILHMdnpGDIFTFqTEHAYGALESIPANSQWFSLFSGVSFIAIIS-NLAWGLGYFGQPHIIVRFMAMRK 273
Cdd:pfam00474 155 LFGTIILMIIVFHEV---GGYSSA-VEKYMTADPNGVDLYTPDGLHILRDPLTGLSlWPGLVLGTTGLPHILQRCLAAKD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 274 PSDATAGRRWGVGWMALCLVGAVFIAIVGPAFF-AEGGYDITDTKNYETNFLDMASILFHPLIAGLILTAVLAAIMSTVS 352
Cdd:pfam00474 231 AKCIRCGVLILTPMFIIVMPGMISRGLFAIALAgANPRACGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLT 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 353 SQLLVVASALVEDIYAGLINK-SATDTTLKNLSRAMIIIVAVIAALVALDP-DSAILGLVEFAWAGFGASFGPVIIAALF 430
Cdd:pfam00474 311 SQLLSSSSAFTHDLYKNIRRKaSATEKELVGRSRIIVLVVISLAILLAVQPaQMGIAFLVQLAFAGLGSAFLPVILLAIF 390
|
....*
gi 521254940 431 WRRLN 435
Cdd:pfam00474 391 WKRVN 395
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
6-486 |
1.27e-75 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 245.93 E-value: 1.27e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIG 85
Cdd:cd10322 1 IDLIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 86 SWCNWKWIAPRLRSYTEIarnsiTIPSFLENRLRDRshTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGLA 165
Cdd:cd10322 81 ALLLALFLAPRLRRLGKT-----TIPETILERYYSK--GLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 166 IIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIftfqtehayGALESIPANSQWFSLFSGVSF 245
Cdd:cd10322 154 IAAVIVILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFS---------ALAAALPALLLALGPGGGLGW 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 246 IAIISN-LAWGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFaeggydiTDTKNYETNFL 324
Cdd:cd10322 225 STILSLiLLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALF-------PDLENPDLALP 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 325 DMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAALVALDPDS 404
Cdd:cd10322 298 TLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPS 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 405 aILGLVEFAWAGFGASFGPVIIAALFWRRLNVPGAVAGMAGGALVAFIWgglpQFNVMDKPFGLYEMIPGVAVNVLLLII 484
Cdd:cd10322 378 -ILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVW----LLLPLASPLGIDPIIPALLVSLIVFVV 452
|
..
gi 521254940 485 VS 486
Cdd:cd10322 453 VS 454
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
38-435 |
8.24e-71 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 232.19 E-value: 8.24e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 38 GGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFselwiAIGLLIGSWCNWKWIAPRLRSYTEIARNSITIPSFLENR 117
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGF-----AIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 118 LRDRshTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLA 197
Cdd:TIGR00813 76 FGKR--ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 198 LVLVPTFAILHMDNPGDIFTfqtehayGALESIPANSQWFSLFSgVSFIAIISNLAWGLGYFGQPH----------IIVR 267
Cdd:TIGR00813 154 TFILPVFAFSEVGGLGTFVE-------KASQAAPTNPSPDDLYD-FFRDPSTSDLPWGAGVFGLPHvalwywtnqvIVQR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 268 FMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFAEGGYDITDTKNYETN--FLDMASILFHPLIAGLILTAVLA 345
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDIDPALAGAVNQNSDqaYPLLVQELMPPGLAGLFLAAILA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 346 AIMSTVSSQLLVVASALVEDIYAGLINK-SATDTTLKNLSRAMIIIVAVIAALVALDPDSAILGLVEFAWAGFGASFGPV 424
Cdd:TIGR00813 306 AVMSTLSSQLNSASTVFTMDLYKKIIRPnASGEKKIVMRGRIAVLVAAVIAGFVAAAQGGQVLQYVQEAFGGLGAPFLPV 385
|
410
....*....|.
gi 521254940 425 IIAALFWRRLN 435
Cdd:TIGR00813 386 FLLGIFWKRMN 396
|
|
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
8-500 |
8.97e-63 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 213.16 E-value: 8.97e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSY---FQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLI 84
Cdd:COG4145 7 LIPLLIYLLLVLGIGIYASrkrSKGSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLGWVLLAMIQVP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GSWCNWKWIAPRLRSYTEiARNSITIPSFLENRLRdrSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGL 164
Cdd:COG4145 87 TAFLTLGVLGKKFAILGR-KYNAVTLADWLRARYQ--SKALVLLAALLLLLFFIAFMVAQFVGGARLLETVTGISYTTGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 165 AIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVpTFAILHMDnpGDIftfqtEHAYGALESIpaNSQWFSLFSGVS 244
Cdd:COG4145 164 LIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLL-LIGVISAG--GGI-----ENIMSTLAAI--DPNLVSPTGPDG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 245 FI----AIISNLAWGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFaeGGYDITDtknye 320
Cdd:COG4145 234 FLprpfVISFWILVGFGVIGLPHTAVRCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAVL--PDLTVPD----- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 321 tNFLDMASI-LFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSAT--DTTLKNLSRAMIIIVAVIAAL 397
Cdd:COG4145 307 -QVIPTLMVkVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASenEKKLKRLSKLVTLVLGLIVFL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 398 VALDPDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNvPGAVAGMAGGALVAFIwgGLPQFNVmdKPFGLYEMIPGVAV 477
Cdd:COG4145 386 LALNPPDLIIWLNLFAFGGLEAAFFWPLVLGLYWKRAN-ATGAIASMLVGVASYF--LLYYGNP--KIFGFHAIVPSLLI 460
|
490 500
....*....|....*....|...
gi 521254940 478 NVLLLIIVSLRTAAPDDEVTTEF 500
Cdd:COG4145 461 SLIAFLIGSLLGKPPDEERLELF 483
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
8-493 |
5.49e-56 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 194.73 E-value: 5.49e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYF-----QTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGL 82
Cdd:cd10327 2 LLPIIIYLVILLGIGFYARRskkrrSGDFLEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 83 LIGSWCNWKWIAPRLrsyTEIAR--NSITIPSFLenRLRDRSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDY 160
Cdd:cd10327 82 VPTGFLTLGVLGKKF---AIIARkiNAVTIIDYL--RARYNSKALVVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 161 FVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQTEHAYGALESIPANSQWFSLF 240
Cdd:cd10327 157 VTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEAIMATLAEIDPNLLTPFGPGFLSPPYI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 241 SgvSFIAIIsnlawGLGYFGQPHIIVRFMAMRkpsDATAGRR---WGVGWMALCLVGAVFIAIVGPAFfaeggydITDTK 317
Cdd:cd10327 237 L--SFWVLV-----GFGVIGLPQTAVRCMGYK---DSKSMHRamiIGTVVVGFLMLGMHLAGVLGRAV-------LPDLE 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 318 NYETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINK--SATDTTLKNLSRAMIIIVAVIA 395
Cdd:cd10327 300 VPDKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKekKTSEKKVKRISLIITIILGLLV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 396 ALVALDPDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNVPGAvagmaggalVAFIWGGLPQFNVMD----KPFGLYEM 471
Cdd:cd10327 380 FLLAINPPDLIVWLNLFAFGGLEAAFFWPLVLGLYWKRANATGA---------LASMVVGLVSYILITylkiKILGLHPI 450
|
490 500
....*....|....*....|..
gi 521254940 472 IPGVAVNVLLLIIVSLRTAAPD 493
Cdd:cd10327 451 VPSLLLSLIAFIIVSLATKKPD 472
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
6-502 |
5.01e-47 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 171.49 E-value: 5.01e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIG 85
Cdd:COG4147 13 LAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLIYSIGWLVG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 86 swcnwkW------IAPRLRSYTEIarnsiTIPSFLENRLRdrSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGD 159
Cdd:COG4147 93 ------YvlllllLAEYLRNFGKF-----TVPDFLGDRFY--SRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 160 YFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLAlVLVPTFAILHMD--NPGDIFTFQTE-HAYGAlesipANSQW 236
Cdd:COG4147 160 YEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFA-YTVPAVLVLAQFgfNPLPLLAKAAEvHDLGA-----AYLEP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 237 FSLF-SGVSFIAIIsnLAWGLGYFGQPHIIVRFMAMRKPSDAtagrRWGVGWmALCLVGAVFIAIVGPAFFAeGGYDITD 315
Cdd:COG4147 234 GGLVkSPLDFISLG--LALMLGTAGLPHILMRFFTVPDAKEA----RKSVGW-ALGFIGLFYLTAPALGFGA-RALVGPL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 316 TKNYETNFL-------DMASILFhPLIAGL------ILTAV-LAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLK 381
Cdd:COG4147 306 PEWFDTGLIgaadgggNMAVLAL-AEIAGGgnwllgLVAAGaFATILAVVAGLLLAIASAISHDLYANVIKGKATEKEEL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 382 NLSRAMIIIVAVIAALVALD-PDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNVP---GAVAGMAGGALVAFIWGGLP 457
Cdd:COG4147 385 RVARIAAVVIGVVAILLGINaPPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRgavAGMLVGLISALVLIVLSPFV 464
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 521254940 458 QFNVMDKPFGLYEM--IPGVAVNVLLLIIVSLRTAAPDDEVTTEFDE 502
Cdd:COG4147 465 WVLGVDAALFPLENpgLVSMPLGFLVAIVVSLLTPEPPAEDQELVEE 511
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
5-488 |
6.24e-46 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 167.68 E-value: 6.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 5 TWFIIAMVIYLIamlsIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLI 84
Cdd:cd11480 2 GLFFVFVTITLY----ITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GswcnwkW------IAPRLRSYTEIarnsiTIPSFLENRLRdrSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDG 158
Cdd:cd11480 78 G------YvlllllVAEPLRNFGKY-----TVPDFLGARLG--SRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 159 DYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLAlVLVPTFAILHM-------DNPGDIFTFQTEHAyGALESIP 231
Cdd:cd11480 145 PYEVGVVVVGALMIVYVVLGGMRATTWVQIIQYVLLLGA-FLVPAILVLARfggnplgAGPGLLGLAAAAAS-GAGEAYL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 232 ANSQWFSlfSGVSFIAIISNLAwgLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFF----A 307
Cdd:cd11480 223 APGLLLT--DPLDVISLTLALM--LGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVgpdvI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 308 EGGYDITDTKNYETNFLDMASILFHP-LIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRA 386
Cdd:cd11480 299 GAPIAGELDGGGDMAVLLLPEIAGLGdLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPGASERREVRVARI 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 387 MIIIVAVIAALVAL-DPDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNVPGAVAGMAGGALVAFIWGGLPQFNVMDKP 465
Cdd:cd11480 379 AAVVVGVIAILLALlFPPQNVAFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLSPAVSGAPP 458
|
490 500 510
....*....|....*....|....*....|
gi 521254940 466 FGLYEMIP-------GVAVNVLLLIIVSLR 488
Cdd:cd11480 459 GHDFAGFPltnpglvSVPLGFLVAIVVSLL 488
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
6-505 |
3.15e-40 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 152.35 E-value: 3.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIAmvIYLIAMLSIGIWSY-FQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLI 84
Cdd:cd11477 3 WLVIA--LYFLLMLGIGLWFSkRASKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GSWCNWKWIAPRLRsyteiARNSITIPSFLENRLRDR-SHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDY-FV 162
Cdd:cd11477 81 AGLIGAFVFARRWR-----RLRVLTDGEFPEERYGGRyGAPLRQFYAVYFALLSNVDILAWVFLAAIKVSAVFGPWDpWL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 163 GLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTfQTEHAYGALESIPANSQWFSLFSG 242
Cdd:cd11477 156 TILILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFA-QLPEGHLDLFGSGLGASGFYITFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 243 VSFIAIISNLAWGLG--YFGQphiivRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFFaeggYDITDTKNYE 320
Cdd:cd11477 235 FILFFGWYPLSYSGGgwYLAQ-----RYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLY----PDLDDPEADF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 321 TNFLDMASILFHPL-IAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAALVA 399
Cdd:cd11477 306 ELAYPMMIKEYLPAgLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 400 LDPDSaILGLVEFAWAgFGASFGPVIIAALFWRRLNVPGAVAGMAGGALVAFIWGGLPQFNVMDKPFgLYEMIPGVAVNV 479
Cdd:cd11477 386 LASDS-IGGAFWIVLA-LGAGLGGPLILPWLWWRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPEDF-LFSFLVPVLLSL 462
|
490 500
....*....|....*....|....*.
gi 521254940 480 LLLIIVSLRTAAPDDEVTTEFDEATR 505
Cdd:cd11477 463 VVWLAVTLLTPPTDEETLVAFYKKVR 488
|
|
| panF |
TIGR02119 |
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is ... |
8-487 |
1.37e-37 |
|
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This model describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (pfam00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A, Transport and binding proteins, Other]
Pssm-ID: 131174 Cd Length: 471 Bit Score: 144.49 E-value: 1.37e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYF---QTDEY-EDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLL 83
Cdd:TIGR02119 4 VIPLIIYLVTVFLIAIYASKrvqSTDSFlNEYFLGGRSMGGFVLAMTLVATYGSASSFIGGPGIAYNYGLGWVLLAMIQV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 84 IGSWCNWKWIAPRLrsyTEIAR--NSITIPSFLENRLRDRShtLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYF 161
Cdd:TIGR02119 84 PTGYFVLGVLGKKF---AIISRkyNAITINDVLKARYNNKF--LVWLSSISLLVFFFSAMVAQFIGGARLIESLTGLSYL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 162 VGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVlvptfailhmdnpgdIFTFQTEHAYGALESI-----PANSQW 236
Cdd:TIGR02119 159 TALFIFSSSVLIYTTFGGFRAVALTDAIQGIVMFTGTT---------------ILLIAVIKAGGGVEKImeklkDIDPNL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 237 FSLFSG-----VSFIAIISNLAwGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIVGPAFfaeggy 311
Cdd:TIGR02119 224 ITPFGGdggltKPFVASFWILV-GIGVIGLPQTAVRCMSYKDSKAMHRAMIIGTIVVGIIMLGMHLAGVLGRAV------ 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 312 dITDTKNYETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIV 391
Cdd:TIGR02119 297 -IPDLTVPDKVIPLLAIKVLPPILAGIFLAAPMAAIMSTVNSLLLQSSSTIIKDLYLNYIPKEAKESKIKKISMCITLII 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 392 AVIAALVALDPDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNvpgavagmaGGALVAFIWGGLPQFNVMD----KPFG 467
Cdd:TIGR02119 376 GLLVIIAAIKPPDLIIWLNLFAFGGLEAAFIWPIVLGLYWKRAN---------ATGALASMIVGVGSYITLEsfkpKIFG 446
|
490 500
....*....|....*....|
gi 521254940 468 LYEMIPGVAVNVLLLIIVSL 487
Cdd:TIGR02119 447 LHNIVPSLVFALIAFIIGSL 466
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
8-435 |
1.90e-35 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 138.04 E-value: 1.90e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFseLWI-------AI 80
Cdd:cd11474 1 LIGVILYYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGL--GGVaqdpfgyAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 81 GLLIGSWcnwkWIAPRLRsyteiARNSITIPSFLENRLrdrSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDY 160
Cdd:cd11474 79 CLILGGL----FFAKPMR-----RMGLLTLGDFFRQRY---GRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 161 FVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAilhMDNPGdIFTFQTEHAYGALESIPANSQWFSLf 240
Cdd:cd11474 147 ETGILISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFV---LTNPG-GVDIASAAAAGKLRFFPWLGTKSDW- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 241 sgVSFIAIISNLAWGlgyfGQPHIIV--RFMAMRKPSDATAGRRW-GVGWMALCLVgAVFIAIVGPAFFAE--GGYDITD 315
Cdd:cd11474 222 --LIWIDAWLTLGLG----SIPQQDVfqRVLSAKSEKTAQRLSLLaGVGYLLFAIP-PLLIGLAAASIDPSltQYGLEED 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 316 TKNYETNFLDMasiLFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIA 395
Cdd:cd11474 295 AQLILPLLLQY---LTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIA 371
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 521254940 396 ALVALDPDSaILGLVEFAWAGFGASFGPVIIAALFWRRLN 435
Cdd:cd11474 372 TLMALTVES-IYGLVELASDLVLVGLFVPLLAGLYWKRAN 410
|
|
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
5-496 |
2.02e-35 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 139.31 E-value: 2.02e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 5 TWFIIAMVIYLIAmlSIGIWSyfQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLI 84
Cdd:TIGR03648 1 TYLFVGATFALYI--GIGIWS--RAGSTSEFYVAGRGVPPVANGMATAADWMSAASFISMAGLIAFLGYDGLAYLMGWTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GSWCNWKWIAPRLRSYteiarNSITIPSFLENRLRdrSHTLRILSGII-ILVFFTfYVSSGM----VAGGRYFESSFDGD 159
Cdd:TIGR03648 77 GYVLLALLLAPYLRKF-----GKYTVPDFIGDRYY--SNTARLVAVICaIFISFT-YVAGQMrgvgVVFSRFLEVDFETG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 160 YFVGLAIIGVvtvlYTFVGGFLAVSYTDVVQGSMMFLALvLVPTFAILHM--DNP-------GDIFTFQTEHAYGALES- 229
Cdd:TIGR03648 149 VFIGMAIVFF----YAVLGGMKGVTWTQVAQYIVLIVAY-LVPAIFISLKltGNPvpqlgygSALSGVYLLDKLDELEVd 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 230 --IPANSQWFSLFSGVSFIAIIsnLAWGLGYFGQPHIIVRFMAMRKPSDAtagrRWGVGWmalclvGAVFIAI---VGPA 304
Cdd:TIGR03648 224 lgFAEYTEPFGSKSRINVFALT--LALMVGTAGLPHVIVRFYTVPKVRDA----RWSAGW------ALFFIALlytTAPA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 305 FFAEGGYDITDT-------------KNYE-TNFLDMAS------------------------ILFHPLIA-------GLI 339
Cdd:TIGR03648 292 VAAFARYNLITTvngtpyaelpgwvANWEkTGLLKFEDkngdgilqysgdagneltidrdiiVLATPEIAglpywviGLV 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 340 LTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAALVALDPDSAILGLVEFAWAGFGA 419
Cdd:TIGR03648 372 AAGGLAAALSTAAGLLLVISSAISHDLYYRIINPNASEKQRLLVARIALVVAAVIAGYFGLNPPGFIAQVVAFAFGLAAA 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 420 SFGPVIIAALFWRRLNVPGAVAGMAGGALVAFI-------WGGLPQFNVMDKPFGLYEMIP-------GVAVNVLLLIIV 485
Cdd:TIGR03648 452 SFFPALVLGIFWKRMNREGAIAGMLTGLGFTFSyivyfkpWGFIGTNPGANVPENWWFGISpegigliGMPVNFAVAIVV 531
|
570
....*....|.
gi 521254940 486 SLRTAAPDDEV 496
Cdd:TIGR03648 532 SLVTPPPPQEI 542
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
1-435 |
3.42e-33 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 131.42 E-value: 3.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 1 MSDHTWFIIAMVIYLIAMLSIGIWSYFQTDE--YEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFS---- 74
Cdd:COG4146 1 MGLSTLDYIVFLLYFLLVAGIGYWVSRKKKEktSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAvaay 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 75 ELWIAIGLLIGSWcnwkWIAPRLrsyteIARNSITIPSFLENRLRDRshTLRILSGIIILVFFTFYVSSGMVAGGRYFES 154
Cdd:COG4146 81 EWMAAIALIILAL----FFLPFY-----LKSGIYTMPEFLEKRYDRR--TRTILSILFLVSYVFVNLPSVLYAGALALNT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 155 SFDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQT--EHAYGALESI-P 231
Cdd:COG4146 150 IFGVPLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGDGSVLAGWSAllKVPPEKFNMIgP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 232 ANSQ---WFSLFSGVSFIaiisnlawGLGYFG--QpHIIVRFMAMRKPSDAtagrRWGV---GWMALCLVGAVFI-AIVG 302
Cdd:COG4146 230 ADDPdlpWLGIFTGMPIL--------NLFYWGtnQ-YIVQRALGAKNLKEA----QKGVlfaGFLKLLIPFIVVLpGIIA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 303 PAFFAEGGyditdtKNYETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKN 382
Cdd:COG4146 297 FVLFPDGL------DNPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVK 370
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 383 LSRAMIIIVAVIAALVALdpdsaILGLVEFAWA---GFGASFGP----VIIAALFWRRLN 435
Cdd:COG4146 371 VGRIATVVLAVIAILIAP-----LIGNADGLFQyiqEVTGFFSPpilaVFLLGLFWKRVT 425
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
8-493 |
4.45e-26 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 110.77 E-value: 4.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNP--FVAALSA----GASDMSGWLL---MGLPGAIFVsgfseLWI 78
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGMRRAKTSEDYLVAGRRLGPglYLGTMAAvvlgGASTIGGVGLgyqYGISGMWLV-----VAI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 79 AIGLLIGSWCNWKWIApRLRSYTeiarnsitIPSFLENRLRDRShtlRILSGIIILVFFTFYVSSGMVAGGRYFESSFDG 158
Cdd:cd11479 78 GLGILALSLLLAKRIA-RLKVYT--------VSEVLELRYGPSA---RVISALVMLAYTLMVAVTSTIAIGTVFSVLFGL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 159 DYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLV-PTFAILHMDNPGdiftfqtehayGALESIPAnsQWF 237
Cdd:cd11479 146 PRTLSILVGGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLlLPLALSKAGGLS-----------GLQEKLPA--SYF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 238 SLFSgVSFIAIISN-LAWGLGYFGQPHIIVRFMAMRKPSDATAGrrwGVGWMALCLVGAVFIAIVGPAFFAEggydITDT 316
Cdd:cd11479 213 DLTS-IGWDTIVTYfLLYFFGILIGQDIWQRVFTARSEKVARWG---GVAAGLYCVLYGVAGALIGMAAAVL----LPDL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 317 KNYETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVAVIAA 396
Cdd:cd11479 285 ANPQNAFATMAQEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVI 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 397 LVALDPDSAILGLvEFAWAGF-GASFGPvIIAALFWRRLNVPGAVAGMAGGALVAFIwgglpqFNVMDKPFGLYEMIPGV 475
Cdd:cd11479 365 VIAVLVNDVVAAL-TIAYAILvGGLLVP-ILGGLFWKRATGAGALASMVAGSVVVLA------GMAVDGLLANTPIYYGL 436
|
490
....*....|....*...
gi 521254940 476 AVNVLLLIIVSLRTAAPD 493
Cdd:cd11479 437 AVSLVAFVAVSLLTRPTP 454
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
6-435 |
1.11e-24 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 106.91 E-value: 1.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIamVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIG 85
Cdd:cd11493 2 LAVI--VLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 86 SWCNWKWIAPRLRSYteiarNSITIPSFLENRLRDRSHtlRILSgiiilvfFTFYVSSGMVAGGRYFESS---------- 155
Cdd:cd11493 80 RIIVAFVLLPRYFRG-----EVVSAYELLGQRFGGGMQ--KTAS-------VTFLVTRLLADGVRLFAAAipvsmilgad 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 156 -FDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVptFAILHMDNPGDIFtfQTEHAYGALESIPANS 234
Cdd:cd11493 146 gVALSYIASILIISVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAA--LAYLLGALPADWL--QIAAAAGKFHLFDLSD 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 235 QWFSLFSGVSFI-AIISNLAWGLGYFGQPHIIV-RFMAMRKPSDATAGRRWGvgWMALCLVGAVFIAIVGPAFFAEGGYD 312
Cdd:cd11493 222 LILGLTSPYTFWaAIIGGALLSMASHGTDQLMVqRLLACRNLRDAQKALIGS--GVVVFPQFALFLLIGLLLYVYYGGAS 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 313 ITDTKNYETNFLDMASILfHPL---IAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMII 389
Cdd:cd11493 300 LAALGLGSPDEVFPYFIV-HELpagLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKLLRASRLLTL 378
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 521254940 390 IVAVIAALVALDPDSAILGLVEFAWAGFGASFGP---VIIAALFWRRLN 435
Cdd:cd11493 379 VWAVVLVGIALLFQYTDQPVVELGLSIASFTYGGllgVFLLGLLTRRAS 427
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
8-495 |
1.79e-24 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 106.89 E-value: 1.79e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDE-YEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGA-----IFVSGFSELWIAIG 81
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSSRKKRStVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSgaasgIAVGNYEWNAAFVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 82 LLIGswcnwkWI-APRLrsyteIARNSITIPSFLENRLRDRSHTlrILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDY 160
Cdd:cd10329 81 LLLG------WVfLPFY-----IRSGVSTMPEFLEKRFGGRSRV--YLSVLSLILYVFTKISVDLYAGALVIKQLLGWDL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 161 FVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQT-EHAYGALESIPANSQ--WF 237
Cdd:cd10329 148 YLSIIVLLVITAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGGGWSAYMAAIpSGTAFHLFRPPDDPDlpWP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 238 SLFSGVSFIAIisnlaWglgYFGQPHIIV-RFMAMRKPSDAtagrRWGVGWMALCLVGAVFIAIV----GPAFFAEGGYD 312
Cdd:cd10329 228 GLLLGYPILGI-----W---YWCTDQVIVqRVLAAKNLKHA----RRGALFAGYLKLLPLFLMVLpgmiARALFPDLVAC 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 313 ITDTKNYETN----FLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAgLINKSATDTTLKNLSRAMI 388
Cdd:cd10329 296 VVPCGNGVGCsdiaYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYK-RLRPEASEKELVRVGRIAT 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 389 IIVAVIAALVALDPDSAILGLVEFAWAGFGAsFGPVIIA----ALFWRRLNVPGAVAGMAGGALVAFIwggLPQFNVM-D 463
Cdd:cd10329 375 LVVVVISILWAPIIQAQGGSLFNYIQSVLSY-LAPPIAAvfllGIFWKRTNEQGAFWGLIAGLVLGLV---RLILEFAyG 450
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 521254940 464 KPFGLYEMIPGV----------AVNVLLLIIVSLRTAAPDDE 495
Cdd:cd10329 451 EPDTRPAIIGGIhflyfafllfVVSVIVTVIVSLLTPPPPAE 492
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
4-400 |
1.30e-22 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 100.69 E-value: 1.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 4 HTWFIIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLL 83
Cdd:cd11495 2 GWLDYLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 84 IGSWCNWKWIAPRLRSyteiaRNSITIPSFLENRLrdrSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVG 163
Cdd:cd11495 82 IAAPLAAYFFVPFFRR-----LNVTSAYEYLEKRF---GPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 164 LAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMD-NPGDIFTFQTEHaygalESIPANSQWFSLFSG 242
Cdd:cd11495 154 IILMGVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPgGFGEVFDIAIAN-----GKFSLGDFSFSLTES 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 243 VSFIAIISNLAWGLGYFGQPHIIV-RFMAMRKPSDAtAGRRWGVGWMALClVGAVFIAIvGPA---FFAEGGYDITDTKN 318
Cdd:cd11495 229 TIWVIFIGGIFNNLQSYTSDQDVVqRYLTTKSIKEA-KKSLWTNALLALP-VALLFFGI-GTAlyvFYQQHPELLPAGIN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 319 YETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAgLINKSATDTTLKNLSRAMIIIVAVIAALV 398
Cdd:cd11495 306 GDAVFPYFIVTQLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYK-RLSPDPSDKQYLKVARLITLLVGLLGTLV 384
|
..
gi 521254940 399 AL 400
Cdd:cd11495 385 AL 386
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
6-410 |
1.69e-20 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 94.16 E-value: 1.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIamVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIG 85
Cdd:cd10326 2 WAVV--VVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 86 swcnwkwiaprlrsYTEIAR---------NSITIPSFLENRLRDRSH----TLRILSGII---ILVFFTFYVSSGMVAGg 149
Cdd:cd10326 80 --------------YLIIAFvllplyyrlNLTSIYEYLEDRFGVSSRktgaVFFLLSRILgagIRLYLVALVLQQFLFD- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 150 ryfesSFDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMD-NPGDIFTFQTEHAYgale 228
Cdd:cd10326 145 -----SLGIPFWLTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGlGFGEAISAAGESGY---- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 229 sipanSQWFSLFSGVS----FIAIISNLAWGLGYFGQPHIIV-RFMAMRKPSDATAGRRWgvGWMALCLVGAVFIAIVGP 303
Cdd:cd10326 216 -----SRIFNFDDDNSrrtfWKQFLGGIFITIAMTGLDQDMMqRNLSCKNLKDAQKNMLT--FGVILVPVNLLFLLLGVL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 304 AF-FAEGGYDITDTKNYETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKN 382
Cdd:cd10326 289 LYtYAQKNGIALPAKDSDQLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRKSEKKSERKY 368
|
410 420
....*....|....*....|....*....
gi 521254940 383 LSRAMIII-VAVIAALVALDPDSAILGLV 410
Cdd:cd10326 369 VHIAFSLTfVLGILVFGSASNSGSLIDAI 397
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
6-400 |
4.20e-19 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 89.97 E-value: 4.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIamVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIG 85
Cdd:cd11494 3 WIVL--VGYLLGILVYGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLPLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 86 SWCNWKWIAP---RLRSYteiarnsiTIPSFLENRLRDRShtlRILSGIIilvfftFYVSSGMVAGGRYFESS------F 156
Cdd:cd11494 81 MIFLCITFVPvfyKLKVY--------TAYEYLERRFGLKT---RLLTSIL------FLISRGLATGVTIYAPAiilstiL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 157 DGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVpTFAILHMDNPGDIFTFQTEHAYGALESIPANSQW 236
Cdd:cd11494 144 GWSLWLTILLIGGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIA-FGLLLKLLPVGFVDALLVAGKSGRLNALDFSFDL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 237 FSLFS------GVSFIAiisnlawgLGYFGQPHIIV-RFMAMRKPSDAtagrRWGVGWMAL---------CLVGA-VFIA 299
Cdd:cd11494 223 SDTYTfwsgliGGFFLY--------LSYFGTDQSQVqRYLTAKSIKEA----RKSLLLNGFlkfpmqffiLLIGVlVFVF 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 300 IVGPAFFAEGGYDITDTKNYETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTT 379
Cdd:cd11494 291 YQFNPFPVSFNPAEDETKDTNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEH 370
|
410 420
....*....|....*....|.
gi 521254940 380 LKNLSRAMIIIVAVIAALVAL 400
Cdd:cd11494 371 YLKVSRLLTVFWGLLAIVFAL 391
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
7-435 |
1.26e-17 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 85.72 E-value: 1.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 7 FIIAMVIyliaMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSE-LWIAIG---- 81
Cdd:cd11476 11 FALLMVF----ITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGpFWYASGatlq 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 82 -LLIGSwcnwkwIAPRLRsytEIARNSITIPSFLENRLRDRSHTLRILSGIIILVFFTfyvSSGMVAGGRYFESSFDGDY 160
Cdd:cd11476 87 iLLFAP------LAIRIK---RLAPNAHTLLEIVRARYGTAAHLVFLVFALFTNVIVL---AMLLLGGSAVVNALTGMPI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 161 FVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMD--NPGDIFTFQTEHAYGALESIPANSQWFS 238
Cdd:cd11476 155 VAASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTSSDigSPSKVYDLLQEAAPDLPVEGNQGSYLTF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 239 LFSGVSFIAIISNLAwGLGY-FGQPHIIVRFMAMRKPSDA-----TAGRRWGVGWMALCLVGAVFIAIVGPAFFAEGGYD 312
Cdd:cd11476 235 KSKAGLIFGIINIVG-NFGTvFLDQGYWQRAIAARPSAAVkgyflGGLAWFAIPFLLATTLGLAALALGLNPTFEEVSAG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 313 ITdtknyetnFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVA 392
Cdd:cd11476 314 LV--------LPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFG 385
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 521254940 393 VIAALVALDPDSA---ILGLVEFAWAGFGASFGPViIAALFWRRLN 435
Cdd:cd11476 386 LFMGGLAVGLNYIgisLGWLLLFMGILIGSAVFPV-ALGLYWRRQT 430
|
|
| actP |
PRK09395 |
cation/acetate symporter ActP; |
6-434 |
8.71e-17 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 83.10 E-value: 8.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIAM-VIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLI 84
Cdd:PRK09395 34 WQAIIMfLIFVVFTLGITYWAAKRTRSASDFYTAGGGITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GswcnwkW------IAPRLRS---YTeiarnSITIPSFlenRLRDRShtLRILSGIIILVFFTFYVSSGMVAGGRYFESS 155
Cdd:PRK09395 114 G------WpiilflIAERLRNlgkYT-----FADVASY---RLKQGP--IRTLSACGSLVVVALYLIAQMVGAGKLIQLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 156 FDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVptfAILHMDNPGdiFTFQTEHAygalESIPANSQ 235
Cdd:PRK09395 178 FGLNYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAVLLLSGATFM---AFMVMKHVG--FSFENLFS----EAVAVHPK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 236 WFSLFSGVSFIA-IISNLAWGL----GYFGQPHIIVRFMAMrkpSDATAGRR---WGVGWMALCLV-------GAVFIAI 300
Cdd:PRK09395 249 GLAIMGPGGLVKdPISALSLGLalmfGTAGLPHILMRFFTV---SDAKEARKsvfYATGFIGYFYIltfiigfGAIVLVG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 301 VGPAFFAEGGYDITDTknyetnflDMASILFHPLIAGLI----LTAV-LAAIMSTVSSQLLVVASALVEDIYAGLINK-S 374
Cdd:PRK09395 326 TNPEFKDAAGALIGGN--------NMAAVHLANAVGGNLflgfISAVaFATILAVVAGLTLAGASAVSHDLYANVIKKgK 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 521254940 375 ATDTTLKNLSRAMIIIVAVIA-ALVALDPDSAILGLVEFAWAGFGASFGPVIIAALFWRRL 434
Cdd:PRK09395 398 ATERDELRVSKITTLVLGVVAiILGILFEKQNIAFMVGLAFAIAASANFPVLLLSMYWKGL 458
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
3-424 |
1.73e-16 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 82.15 E-value: 1.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 3 DHTWFIIAMVIYLiamlSIGIWSYF---QTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIA 79
Cdd:cd11492 2 DYVVFVAMLLISA----AIGIYFGFfggKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 80 IGLLIGSwcnwkwiaprlrsyteIARNSITIPSF-----------LENRLrdrSHTLRILSGIIILVFFTFYVSSGMVAG 148
Cdd:cd11492 78 IAYVLVG----------------PITAYIFLPVFynlqltsvyeyLELRF---NRRVRLLASFLFILQMLLYLPIVIYAP 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 149 GRYFESSFDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQTEHayGALE 228
Cdd:cd11492 139 ALALSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGGFSEVWEIAEEG--GRLE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 229 SIPANsqwFSLFSGVSF-IAIISNLAWGLGYFG-QPHIIVRFMAMRKPSDAtagrRWGVGWMALCLVGAVFIAI-VGPAF 305
Cdd:cd11492 217 FFNFD---PDPTVRHTFwSLVIGGTFTWLSLYGvNQTQVQRYLSLPSLKSA----KKALWLNIVGLILILSLCCfTGLVI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 306 FAEggY---DITDTKNYETN-----FLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATD 377
Cdd:cd11492 290 YAK--YhdcDPLTAGLIKKPdqllpYFVMDVLGHLPGLPGLFVAGIFSAALSTLSSGLNSLAAVILEDFIKPFFKKKLSE 367
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 521254940 378 TTLKNLSRAMIIIVAVIA-ALVALdpdSAILG-LVEFAWAGFGASFGPV 424
Cdd:cd11492 368 RQATNIMKLLVVVFGLLCiGLAFL---VEKLGgVLQLSLSIFGITGGPL 413
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
8-434 |
2.73e-16 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 81.77 E-value: 2.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIGSW 87
Cdd:PRK12488 35 IGMFMVFVLFTLGITRWAARRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNGYDGLLYALGVLAGWP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 88 CNWKWIAPRLRSYTEIARNSITipsflenRLRDRSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGLAII 167
Cdd:PRK12488 115 IILFLIAERLRNLGKYTFADVV-------SYRLAQGPVRLTAAFGTLTVVLMYLVAQMVGAGKLIELLFGISYLYAVVIV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 168 GVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQTEHAYGALESIPANSQWFSlfsgVSFIA 247
Cdd:PRK12488 188 GALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHFGFSTEAMFASAVAVHAKGQAILAPGGLLS----NPIDA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 248 IISNLAWGLGYFGQPHIIVRFMAMRKPSDATAGRRWGVGWMA-----LCLVGAVFIAIVG--PAFFAEGGYDITDTKNYE 320
Cdd:PRK12488 264 ISLGLGMMFGTAGLPHILMRFFTVSDAREARKSVLYATGFIGyfyllIIVVGFGAIVMVGtePSYRDAGGKIIGGGNMVA 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 321 tnfLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTT----LKNLSRAMIIIVAVIAA 396
Cdd:PRK12488 344 ---VHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIRKGQASEAqemrVSKIATLGIGLLAVVLG 420
|
410 420 430
....*....|....*....|....*....|....*...
gi 521254940 397 LVALDPDSAILGLVEFAWAGfGASFgPVIIAALFWRRL 434
Cdd:PRK12488 421 LMFESQNIAFLSGLVLAIAA-SVNF-PVLFLSMFWKGL 456
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
12-433 |
1.98e-14 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 75.80 E-value: 1.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 12 VIYLIAMLSIGIWSYfQTDE-----YEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFS----ELWIAIGL 82
Cdd:cd10325 4 IVYVILIIGLGLWVS-REKKggekdATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAiasyEWMAAITL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 83 LIGSwcnwKWIAPRLrsyteIARNSITIPSFLENRLRDRSHTLRILSGIIILVFFTfyVSSGMVAGGRYFESSFDGDYFV 162
Cdd:cd10325 83 IIVA----KFFLPIF-----LKNGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVN--LTSVLYLGALAIETITGIPLTY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 163 GLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHM-DNPGDIFTFQTE--HAYGALESIPANSQWFSL 239
Cdd:cd10325 152 SIIGLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLgGGEGVFAGFTLLaaEAPEHFHMILDKSNPEDA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 240 FSGVSFIAIISNLAW--GLGYFG-QPHIIVRFMAMRKPSDAtagrRWGVGWMA-LCLVGAVFIAIVGPAFFAEGGYDITD 315
Cdd:cd10325 232 YKDLPGIAVLLGGLWvaNLSYWGfNQYIIQRALAAKSLSEA----QKGIVFAAfLKLLIPFIVVIPGIAAYVLASNLLLP 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 316 TKNYETNFLDMASILFHPL---IAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTLKNLSRAMIIIVA 392
Cdd:cd10325 308 AATGIEKPDQAYPWLLRNLptgLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIAL 387
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 521254940 393 VIAALVA---LDPDSAILGLVEFawAGFgasFGPVIIA----ALFWRR 433
Cdd:cd10325 388 IIAALIApplLGLDQAFQYIQEY--TGF---ISPGILAifllGLFWKR 430
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
8-399 |
2.54e-14 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 75.30 E-value: 2.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQT-----DEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFS----ELWI 78
Cdd:PRK10484 1 MLTILSFLGFTLLVAVISWWKTrktdtSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSvmawEVTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 79 AIGLLIGSWcnwkWIAPR-LRS-YTeiarnsiTIPSFLENRLrDRShTLRILSGIIILVFFTFYVSSGMVAGGRYFESSF 156
Cdd:PRK10484 81 AIALIILAL----IFLPRyLKSgIT-------TIPDFLEERY-DKT-TRRIVSILFLIGYVVSFLPIVLYSGALALNSLF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 157 DG------DYFVGLAI----IGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHM--DNPGDIFTFQTEHAY 224
Cdd:PRK10484 148 HVsellgiSYGAAIWLlvwlIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALgdGSFMQGLEQLTTVHP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 225 GALESI-PANSQ--WFSLFSGVsfiaIISNL-AWGLgyfgQPHIIVRFMAMRKPSDATAGrrwgvgwMALC----LVGAV 296
Cdd:PRK10484 228 EKLNSIgGATDPvpFPTLFTGL----ILVNLfYWCT----NQSIVQRALGAKNLAEGQKG-------ALLAaffkLLGPL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 297 FIAIVGPAFFAEGGYDITDTknyetnflDMA------SILFHPLIaGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGL 370
Cdd:PRK10484 293 ILVLPGIIAFHLYGDGLPNA--------DMAyptlvnDVLPVPLV-GFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPI 363
|
410 420
....*....|....*....|....*....
gi 521254940 371 INKSATDTTLKNLSRAMIIIVAVIAALVA 399
Cdd:PRK10484 364 INPNASEKQLVKVGKKFGFVLAIISMIVA 392
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
6-495 |
8.62e-14 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 73.86 E-value: 8.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 6 WFIIAmvIYLIAMLSIGIWSYFQTDEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELwiaigllig 85
Cdd:cd11478 3 YLIVA--VYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATV--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 86 swcNWKWIA-------------PRLrsYTEIARnsiTIPSFLENRLRDRSHTLrilSGIIILVFFTFYVSSGMVAGGRYF 152
Cdd:cd11478 72 ---HFYWIGaipamvflgivmmPFY--YGSKVR---SVPEYLKLRFNKSTRLL---NAVSFAVMTILMSGINLYALALVL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 153 ESSFDGDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVpTFAILH--------MDNPGDIFTFQTEHAY 224
Cdd:cd11478 141 NVLLGWPLWLSIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPL-VIIGLIkvggwdglSEKIDANGPPGWNGLS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 225 GALESIPANSQW---FSLFSGVSFIAiisnlawGLGYFGQPHIIV-RFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAI 300
Cdd:cd11478 220 WGPQGSQSTNPMgvnLGLVFGLGFVL-------SFGYWTTNFLEVqRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 301 VGPAFFAEGGYDITDTknYETNFLDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKSATDTTL 380
Cdd:cd11478 293 IALVLVPELGASGGLD--YNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHY 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 381 KNLSR---AMIIIVAVIAALVALDpDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNVPGAVA---GMAGGALVAFIW- 453
Cdd:cd11478 371 LKVGRiatVVGVLISIGTAYIASS-FNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWgllAGTASAIVLYGLy 449
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 521254940 454 --GGLPQFNVMDKPFglYEMIPGVAVNVLLLIIVSLRTAA-PDDE 495
Cdd:cd11478 450 elGLIVYHSDMAPNF--YGAWWAFVVCFVVTVLVSLLTKPkPEKE 492
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
14-399 |
1.10e-13 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 73.34 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 14 YLIAMLSIGIWSYFQT-----DEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFS----ELWIAIGLLI 84
Cdd:cd10328 1 FLLFTALVALISWYKTrgddlSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSvmawEVTAAIALII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GSWcnwkWIAPR-LRSyteiarNSITIPSFLENRLRDrsHTLRILSGIIIL----VFFTFYVSSGMVAGGRYF--ESSFD 157
Cdd:cd10328 81 LAL----VFLPRyLKG------GITTIPEFLEERYDE--TTRRIVSILFLLgyvvILLPIVLYSGALALNSLFdvSELLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 158 GDYFVGLAI----IGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHM--DNPGDIFTFQTEHAYGALESI- 230
Cdd:cd10328 149 ISYFQALWLlvwlIGIIGAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALgdGSFLAGLDTLLTAHPEKLNAIg 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 231 PANSQ--WFSLFSGVSFIAIisnLAWGLGYFgqphIIVRFMAMRKPSDATAGrrwgvgwmalcLVGAVFIAIVGPAF--- 305
Cdd:cd10328 229 GADSPvpFSTLFTGMLLVNL---FYWCTNQA----IIQRALAAKNLKEGQKG-----------VLLAGFFKLLVPLIlvl 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 306 -----FAEGGYDITDTknyetnflDMA------SILFHPLIaGLILTAVLAAIMSTVSSQLLVVASALVEDIYAGLINKS 374
Cdd:cd10328 291 pgiiaFHLYGDGLENA--------DMAyptlvaDVLPKWLS-GFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKN 361
|
410 420
....*....|....*....|....*
gi 521254940 375 ATDTTLKNLSRAMIIIVAVIAALVA 399
Cdd:cd10328 362 ATDKQLVKVGKIFGIVLALISMIIA 386
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
8-513 |
5.68e-12 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 68.04 E-value: 5.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDE--YEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGA-----IFVSGFSelWIAI 80
Cdd:cd11488 2 IAVVVVYFVFVLAVGIWSSIRASRgtVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTgaaggLAVGGFE--WNAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 81 GLLIGswCNWKWIAprlrsyTEIARNSITIPSFLENRLRDRShtLRILSGIIILVFFTFY-VSSGMVAGGRYFESSFDGD 159
Cdd:cd11488 80 WVLIA--LGWIFVP------VYIAAGVVTMPEYLKKRFGGQR--IRIYMSVLSLILYIFTkISTDIFSGALFIQVSLGWN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 160 YFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQG--------SMMFLALVLVPTF---------AILHMDNPGDIFTFQTEH 222
Cdd:cd11488 150 LYLSTVILLAVTALYTIAGGLTAVIYTDALQTvimvigafVLMFIAFDKVGWYpgleqqyekAIPALTVPNTTCHLPRSD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 223 AYGAL-ESIPANSQWFSLFSGVSFIAiisNLAWGLGYFgqphIIVRFMAMRKPSDATAGRRWGVGWMALCLVGAVFIAIV 301
Cdd:cd11488 230 AFHIFrDPVTGDIPWPGLIFGLTVLA---TWVWCTDQV----IVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMI 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 302 GPAFFAE--GGYDITDTKNYETNFLDMASILFHPLIA--------GLILTAVLAAIMSTVSSQLLVVASALVEDIYAgLI 371
Cdd:cd11488 303 SRALFPDevGCVDPDECQKICGAKVGCSNIAYPKLVVelmpvglrGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQ-RI 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 372 NKSATDTTLKNLSRAMIIIVAVIAALVALDPDSAILGLVEFAWAGFGASFGP----VIIAALFWRRLNVPGAVAGMAGGA 447
Cdd:cd11488 382 RRRASEQELMVVGRVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPpitaVFILAIFWKRVNEPGAFWGLMVGL 461
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521254940 448 LVA-------FIWGGLPQFNVMDKP------FGLYEMIPGVAVNVLLLIIVSLRTAAPDDEVTTEFDEATRLARLAESD 513
Cdd:cd11488 462 VVGlvrmimeFVYGAPSCGETDLRPsvlkdvHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVE 540
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
8-201 |
6.70e-09 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 58.38 E-value: 6.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQT--DEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAI-GLLI 84
Cdd:cd11490 2 IVVLVLYFLFVLAVGLWSMWKTkrSTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWnGLFM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 85 GSWCNWKWIAprlrsyTEIARNSITIPSFLENRLRDRShtLRILSGIIILVFFTFY-VSSGMVAGGRYFESSFDGDYFVG 163
Cdd:cd11490 82 VLVLAWLFLP------IYIASRVTTMPEYLKKRFGGKR--IQIFLAVLYLFIYIFTkISVDMYAGAVFIQQALQWDLYLA 153
|
170 180 190
....*....|....*....|....*....|....*....
gi 521254940 164 LAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFL-ALVLV 201
Cdd:cd11490 154 VVGLLGITALYTVAGGLAAVIYTDALQTIIMVIgALILM 192
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
8-437 |
8.50e-09 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 58.02 E-value: 8.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDE--YEDYMVGGRGLN--PFVAALSA---GASDMSGWLLMGLPGAIFVSGFSelWIAI 80
Cdd:cd11486 3 ISVIVIYFVVVLAVGVWAMVSTNRgtVGGFFLAGRSMVwwPIGASLFAsniGSGHFVGIAGTGAAAGIAIGGFE--WNAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 81 GLLIgsWCNWKWIAPRLRSyteiarNSITIPSFLENRLRDRShtLRILSGIIILVFFTFY-VSSGMVAGGRYFESSFDGD 159
Cdd:cd11486 81 VVVV--VLGWLFVPIYIKA------GVVTMPEYLRKRFGGQR--IQVYLSVLSLCLYIFTkISADIFSGAIFINLALGLN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 160 YFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAI-----------LHMDNPGDIFTFQTEHAYGALE 228
Cdd:cd11486 151 LYLAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFnevggydafmeKYMTAIPSVIGTGNSTSQEKCY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 229 SIPANSqwFSLFSGvsfiAIISNLAW----------GLGYFGQPHIIV-RFMAMRKPSDATAGRRWgVGWMALClvgAVF 297
Cdd:cd11486 231 TPRADS--FHIFRD----PITGDLPWpgllfglsilTLWYWCTDQVIVqRCLSAKNMSHVKAGCIL-CGYLKLL---PMF 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 298 IaIVGPAFFAEGGY-------DITDTKNYETNFLDMASILFHPLIA--------GLILTAVLAAIMSTVSSQLLVVASAL 362
Cdd:cd11486 301 I-MVMPGMISRILYtdeiacvVPDECKAVCGTEVGCTNIAYPKLVVelmpnglrGLMLSVMLASLMSSLTSIFNSASTLF 379
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521254940 363 VEDIYAGlINKSATDTTLKNLSRAMIIIVAVIA----ALVALDPDSAILGLVEFAWAGFGASFGPVIIAALFWRRLNVP 437
Cdd:cd11486 380 TMDIYTK-VRKKASEKELMIAGRLFMLVLIGISiawvPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEP 457
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
8-190 |
2.64e-08 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 56.47 E-value: 2.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDE--YEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPG-----AIFVSGFSELWIAI 80
Cdd:cd11487 3 ISVIAAYFLLVIGVGLWSMCRTNRgtVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGtgaasGIAVAGFEWNALFV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 81 GLLIGswcnWKWIAPRLRSyteiarNSITIPSFLENRLRDRShtLRILSGIIILVFFTFY-VSSGMVAGGRYFESSFDGD 159
Cdd:cd11487 83 VLLLG----WLFVPVYLTA------GVITMPQYLKKRFGGQR--IRLYLSVLSLFLYIFTkISVDMFSGAVFIQQALGWN 150
|
170 180 190
....*....|....*....|....*....|.
gi 521254940 160 YFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQ 190
Cdd:cd11487 151 IYASVIALLGITMIYTVTGGLAALMYTDTVQ 181
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
15-366 |
2.12e-07 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 53.69 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 15 LIAMLSIGIWSYFQT---DEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIGSWCNWK 91
Cdd:cd11503 10 LLVSTGIGLFVGLARggqRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSLMTAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 92 WIAPRLRsyteiaRNSITIPS-FLENRLrdrSHTLRILSGIIILVFFTFYVSSGMVAGGRYFESSFDGDYFVGLAIIGVV 170
Cdd:cd11503 90 LFMPVFY------RLGITSTYqYLEMRF---SRAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 171 TVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAILHMDNPGDIFTFQTEHAYGALESIPANSQwfSLFSGVSFIaIIS 250
Cdd:cd11503 161 CTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLIRGVILVGGPRRVLEIAQNHSRINFMDFDPDPR--RRYTFWTFV-VGG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 251 NLAWGLGYFGQPHIIVRFMAMRKPSDATAGRRwgVGWMALCLV--GAVFIAIVGPAFFAE-----GGYdITDTKNYeTNF 323
Cdd:cd11503 238 TLVWLSMYGVNQAQVQRYVACRTEKQAKLALL--VNQVGLCLIvsSAATCGIVMFVYYSNcdpllIGR-ISAPDQY-MPY 313
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 521254940 324 LDMASILFHPLIAGLILTAVLAAIMSTVSSQLLVVASALVEDI 366
Cdd:cd11503 314 LVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDL 356
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
8-201 |
1.19e-06 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 51.09 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQT--DEYEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGA-----IFVSGFSelWIAI 80
Cdd:cd11489 5 IIVIGVYFALNVAVGIWSSCRVsrNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTgaaggIAVAGFE--WNAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 81 GLLIGswcnWKWIAPRLRSYTEIarnsITIPSFLENRL---RDRSHtlriLSGIIILVFFTFYVSSGMVAGGRYFESSFD 157
Cdd:cd11489 83 YALLA----LAWVFVPVYISSGI----VTMPEYLQRRFggeRIRMY----LSVLSLLLSVFTKISTDLYSGALFVQVCLG 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 521254940 158 GDYFVGLAIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLV 201
Cdd:cd11489 151 WNLYLSTVLMLVVTALYTIAGGLAAVIYTDALQTLIMVIGAVIL 194
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
8-207 |
5.15e-06 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 49.09 E-value: 5.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 8 IIAMVIYLIAMLSIGIWSYFQTDE--YEDYMVGGRGLNPFVAALSAGASDMSGWLLMGLPGAIFVSGFSELWIAIGLLIG 85
Cdd:cd11491 2 IAVVALYFILVMCIGIYAMWKSNRstVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521254940 86 SWCnWKWIaprlRSYTEIARNSITIPSFLENRLrdRSHTLRILSGIIILVFFTFY-VSSGMVAGGRYFESSFDGDYFVGL 164
Cdd:cd11491 82 LQL-LGWV----FIPVYIRSGVYTLPEYLSKRF--GGHRIQVYLAALSLILYIFTkISVNLYSGALFIQEALGWNLYVSI 154
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 521254940 165 AIIGVVTVLYTFVGGFLAVSYTDVVQGSMMFLALVLVPTFAIL 207
Cdd:cd11491 155 ILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMM 197
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