|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
2-445 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 801.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 2 TTKYDNSNVNNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINS 81
Cdd:PRK05613 1 MPKYDNSNADQWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 82 LEGGVHAVAFASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAWAAAVQPNTKAFY 161
Cdd:PRK05613 81 LEGGVHAVAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDPESWQAAVQPNTKAFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 162 GETFANPQADVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSVE 241
Cdd:PRK05613 161 GETFANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTVE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 242 RDGTPVFPTFVAPDPAYHGLKYVDLGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLD 321
Cdd:PRK05613 241 RDGKPVFPYFVTPDPAYHGLKYADLGAPAFGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 322 ASPLVAKVNYAGLESSPWYPVKEKLGIEYTGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPAT 401
Cdd:PRK05613 321 NHEKVAKVNFAGLKDSPWYATKEKLGLKYTGSVLSFDI-------KGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPAT 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 521255256 402 TTHSQSDRHGLERAGINRATVRLSVGIENLEDILADLQLGFDAL 445
Cdd:PRK05613 394 TTHSQSDEAGLARAGITQATVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
11-446 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 673.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 11 NNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVA 90
Cdd:COG2873 4 KKYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAALA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 91 FASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQA 170
Cdd:COG2873 84 TASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFV-DPDDPEAFEAAIDPNTKAIFGETIGNPAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 171 DVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSV-ERdgtpvFP 249
Cdd:COG2873 163 DVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAAnGK-----FP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 250 TFVAPDPAYHGLKYVD-LGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAK 328
Cdd:COG2873 238 ELTEPDPSYHGLVYTEaFGNAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAW 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 329 VNYAGLESSPWYPVKEKLGIEYTGSVLSFDLAVDdtwsdeaQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSD 408
Cdd:COG2873 318 VNYPGLPSHPYHELAQKYLPKGAGGVLTFGLKGG-------REAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLS 390
|
410 420 430
....*....|....*....|....*....|....*...
gi 521255256 409 RHGLERAGINRATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:COG2873 391 EEEQAAAGVTPDLIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
14-442 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 634.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 14 GFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFAS 93
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 94 GQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVL 173
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFV-DPDDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 174 DIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSVERdgtpvFPTFVA 253
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNNGR-----FPLFTT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 254 PDPAYHGLKYVD-LGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYA 332
Cdd:TIGR01326 235 PDPSYHGLVFTEtLGNPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 333 GLESSPWYPVKEKLGIEYTGSVLSFDLAvddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGL 412
Cdd:TIGR01326 315 GLASHPHHALAKKYLPKGFGAVLSFEIK-------GGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQ 387
|
410 420 430
....*....|....*....|....*....|
gi 521255256 413 ERAGINRATVRLSVGIENLEDILADLQLGF 442
Cdd:TIGR01326 388 LKAGVTPGLIRLSVGIENIDDIIADLEQAL 417
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
12-444 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 580.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 12 NWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAF 91
Cdd:PRK07812 11 NWSFETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 92 ASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAWAAAVQPNTKAFYGETFANPQAD 171
Cdd:PRK07812 91 ASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEDPDDLDAWRAAVRPNTKAFFAETISNPQID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 172 VLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSVERdgtpvFPTF 251
Cdd:PRK07812 171 VLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQGR-----FPGF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 252 VAPDPAYHGLKYVDLGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNY 331
Cdd:PRK07812 246 TTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNY 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 332 AGLESSPWYPVKEKLGIEYTGSVLSFDLAvddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHG 411
Cdd:PRK07812 326 AGLPSSPWYERAKRLAPKGTGAVLSFELA-------GGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEE 398
|
410 420 430
....*....|....*....|....*....|...
gi 521255256 412 LERAGINRATVRLSVGIENLEDILADLQLGFDA 444
Cdd:PRK07812 399 QLATGVTPGLVRLAVGIEGIDDILADLEAGFAA 431
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
14-444 |
1.70e-160 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 459.97 E-value: 1.70e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 14 GFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFAS 93
Cdd:PRK08134 8 GFDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 94 GQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADnPDAWAAAVQPNTKAFYGETFANPQADVL 173
Cdd:PRK08134 88 GQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGD-IDGWRAAIRPNTRLLFGETLGNPGLEVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 174 DIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWsverDGTPVFPTFVA 253
Cdd:PRK08134 167 DIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDW----EASGKFPELTE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 254 PDPAYHGLKYVD-LGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYA 332
Cdd:PRK08134 243 PYAGFHGMVFAEeSTVAAFLLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 333 GLESSPWYPVKEKLGIEYTGSVLSFDLAvddtwSDEAQEKAwtFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGL 412
Cdd:PRK08134 323 ELESHPDHALAKRLLPRGAGSVFSFDLK-----GGRAAGRK--FIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAAL 395
|
410 420 430
....*....|....*....|....*....|..
gi 521255256 413 ERAGINRATVRLSVGIENLEDILADLQLGFDA 444
Cdd:PRK08134 396 AAAGIGEGTIRLSIGLEDADDLIDDLKRALKA 427
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
7-439 |
1.19e-156 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 450.06 E-value: 1.19e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 7 NSNVNNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGV 86
Cdd:PRK08248 1 MSEERTFRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 87 HAVAFASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFA 166
Cdd:PRK08248 81 GALAVSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFV-DPSDPENFEAAITDKTKALFAETIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 167 NPQADVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSverdGTP 246
Cdd:PRK08248 160 NPKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWK----GSG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 247 VFPTFVAPDPAYHGLKYVD-LGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPL 325
Cdd:PRK08248 236 KFPGLTEPDPSYHGLVYTDaVGEAAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 326 VAKVNYAGLESSPWYPVKEKLGIEYTGSVLSFDLavddTWSDEAQEKawtFIDALKLHSNLANIGDVRSLVVHPATTTHS 405
Cdd:PRK08248 316 VEWVSYPGLPSHPSYELAKKYLPKGQGAILTFGI----KGGVEAGKK---LIDSVKLFSHLANVGDSKSLIIHPASTTHQ 388
|
410 420 430
....*....|....*....|....*....|....
gi 521255256 406 QSDRHGLERAGINRATVRLSVGIENLEDILADLQ 439
Cdd:PRK08248 389 QLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLR 422
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
11-439 |
2.44e-149 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 431.44 E-value: 2.44e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 11 NNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVA 90
Cdd:PRK05994 4 RSPGFATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 91 FASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQA 170
Cdd:PRK05994 84 VASGHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWA-DADDPASFERAITPRTKAIFIESIANPGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 171 DVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSveRDGTpvFPT 250
Cdd:PRK05994 163 TVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWS--KSGK--YPM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 251 FVAPDPAYHGLKYVD-LGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKV 329
Cdd:PRK05994 239 LSEPRPEYHGLVLHEtFGNFAFAIAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 330 NYAGLESSPWYPVKEKLGIEYTGSVLSFDLAvddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDR 409
Cdd:PRK05994 319 NYAGLPDDPYHALAQKYSPKGAGAVFTFGLK-------GGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTD 391
|
410 420 430
....*....|....*....|....*....|
gi 521255256 410 HGLERAGINRATVRLSVGIENLEDILADLQ 439
Cdd:PRK05994 392 EQKVAAGAGPDVVRLSIGIEDVDDIIADLE 421
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
13-445 |
1.18e-143 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 415.60 E-value: 1.18e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 13 WGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFA 92
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 93 SGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADV 172
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFV-DPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 173 LDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILvdggkfdwsverdgtpvfptfV 252
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAV---------------------V 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 253 APDPAYHglkyvdlgapafglKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYA 332
Cdd:COG0626 219 GRDEELA--------------ERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYP 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 333 GLESSPWYPVKEKL--GieyTGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRH 410
Cdd:COG0626 285 GLPSHPGHELAKRQmsG---FGGMLSFEL-------KGGREAARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPE 354
|
410 420 430
....*....|....*....|....*....|....*
gi 521255256 411 GLERAGINRATVRLSVGIENLEDILADLQLGFDAL 445
Cdd:COG0626 355 ERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
19-444 |
1.80e-139 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 406.21 E-value: 1.80e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 19 AVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAE 98
Cdd:PRK06084 7 AIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 99 TAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDIPTI 178
Cdd:PRK06084 87 TYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFA-AHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 179 AEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSVERDGtpvFPTFVAPDPAY 258
Cdd:PRK06084 166 ADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKER---FALLNTPDPSY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 259 HGLKYVD-LGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLESS 337
Cdd:PRK06084 243 HGVTYTEaFGPAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 338 PwypvKEKLGIEYTG----SVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLE 413
Cdd:PRK06084 323 P----EHELARRYMGgkpaSILSFGI-------KGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELE 391
|
410 420 430
....*....|....*....|....*....|.
gi 521255256 414 RAGINRATVRLSVGIENLEDILADLQLGFDA 444
Cdd:PRK06084 392 KAGVSRDMVRLSIGIEHIDDIIADLAQALDA 422
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
16-443 |
1.17e-138 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 402.38 E-value: 1.17e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 16 ASRAVHAGQTVDSDTGARNQPIYLTTAYVFnsaehakqRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQ 95
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVF--------DFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 96 AAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDI 175
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFV-DTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 176 PTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKfdwsverdgtpvfptfvapd 255
Cdd:pfam01053 152 EAIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGE-------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 256 payhglkyvDLGAPAFGLKarvgllRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLE 335
Cdd:pfam01053 212 ---------ELGKELYFLQ------NATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLP 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 336 SSPWYPVKEKLGIEYtGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERA 415
Cdd:pfam01053 277 SHPGHELAKRQMKGF-GGMLSFEL-------KGGLEAAKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAA 348
|
410 420
....*....|....*....|....*...
gi 521255256 416 GINRATVRLSVGIENLEDILADLQLGFD 443
Cdd:pfam01053 349 GITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
31-443 |
3.83e-138 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 400.81 E-value: 3.83e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 31 GARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAETAAILNLAGAGD 110
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 111 HIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDIPTIAEVAHRNNVPLI 190
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFV-DPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 191 VDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKfdwsverdgtpvfptfvapdpayhglkyvdlgapA 270
Cdd:cd00614 160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGE----------------------------------A 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 271 FGLKARVGLLRdTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLESSPWYPVKEKLGIEY 350
Cdd:cd00614 206 LIQRLRFLRLA-LGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGY 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 351 tGSVLSFDLAVDDtwsdeaqEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERAGINRATVRLSVGIEN 430
Cdd:cd00614 285 -GGVFSFELKGGL-------EAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIED 356
|
410
....*....|...
gi 521255256 431 LEDILADLQLGFD 443
Cdd:cd00614 357 VEDLIADLEQALK 369
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
9-444 |
1.39e-129 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 379.73 E-value: 1.39e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 9 NVNNWGFASRAVHAGQtVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHA 88
Cdd:PRK08133 1 DDDSLGFDTLAVRAGQ-LRSPFGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 89 VAFASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANP 168
Cdd:PRK08133 80 VATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFV-DLTDLDAWRAAVRPNTKLFFLETPSNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 169 QADVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFdwsVErdgtPVF 248
Cdd:PRK08133 159 LTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKEL---ME----EVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 249 ptfvapdpayhglkyvdlgapafglkarvGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAK 328
Cdd:PRK08133 232 -----------------------------GFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVER 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 329 VNYAGLESSPWYPV---KEKLGieytGSVLSFDLAvddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHS 405
Cdd:PRK08133 283 VFYPGLPSHPQHELakrQQKGG----GAIVSFEVK-------GGREAAWRVIDATRLISITANLGDTKTTITHPATTTHG 351
|
410 420 430
....*....|....*....|....*....|....*....
gi 521255256 406 QSDRHGLERAGINRATVRLSVGIENLEDILADLQLGFDA 444
Cdd:PRK08133 352 RLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
16-438 |
6.20e-107 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 321.80 E-value: 6.20e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 16 ASRAVHAGQtVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQ 95
Cdd:TIGR01325 1 ATLAVRGGM-LRSGFEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 96 AAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDI 175
Cdd:TIGR01325 80 AAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFV-DGTDLSAWEAALKPNTKAVFVETPSNPLQELVDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 176 PTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILvdggkfdwsverdgtpvfptfvapd 255
Cdd:TIGR01325 159 AAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAI------------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 256 payhglkyvdLGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLE 335
Cdd:TIGR01325 214 ----------LGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 336 SSPWYPVKEKlGIEYTGSVLSFDLAvddtwsdeAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERA 415
Cdd:TIGR01325 284 SHPQHELAKR-QMSGGGTVVTFDLD--------CRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAA 354
|
410 420
....*....|....*....|...
gi 521255256 416 GINRATVRLSVGIENLEDILADL 438
Cdd:TIGR01325 355 GIGDGLVRLSVGLEDVDDLIADI 377
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
9-445 |
3.02e-106 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 320.62 E-value: 3.02e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 9 NVNNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHA 88
Cdd:PRK06234 3 NIKKMGFATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 89 VAFASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANP 168
Cdd:PRK06234 83 VVAASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFV-DTSNLEEVRNALKANTKVVYLETPANP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 169 QADVLDIPTIAEVAHRNN--VPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdgGKFDWSVERDGtp 246
Cdd:PRK06234 162 TLKVTDIKAISNIAHENNkeCLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVV--GKEEFINQVKL-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 247 vfptfvapdpayhglkyvdlgapaFGLKARvgllrdTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLV 326
Cdd:PRK06234 238 ------------------------FGIKDM------TGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 327 AKVNYAGLESSPWYPVKEKlGIEYTGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQ 406
Cdd:PRK06234 288 EKVYYPGLESFEYYELAKK-QMSLPGAMISFEL-------KGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSP 359
|
410 420 430
....*....|....*....|....*....|....*....
gi 521255256 407 SDRHGLERAGINRATVRLSVGIENLEDILADLQLGFDAL 445
Cdd:PRK06234 360 YTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALDLI 398
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
12-439 |
5.85e-100 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 305.44 E-value: 5.85e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 12 NWGFASRAVHAGQTvDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAF 91
Cdd:PRK06702 4 SWGKGTICVQGGYT-PKNGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 92 ASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAWAAAVQPNTKAFYGETFANPQAD 171
Cdd:PRK06702 83 ASGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGNPAMN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 172 VLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSVERdgtpvFPTF 251
Cdd:PRK06702 163 VLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNGK-----YPEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 252 VAPDPAYHGLKYV-DLGAPAFGLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVN 330
Cdd:PRK06702 238 VEPDPSYHGVSYVqNFGAAAYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 331 YAGLESSPWYPVKEKLGIEYTGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRH 410
Cdd:PRK06702 318 YPGLDSNENYSLAQKYLKKGASGVLTFGI-------KGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAE 390
|
410 420
....*....|....*....|....*....
gi 521255256 411 GLERAGINRATVRLSVGIENLEDILADLQ 439
Cdd:PRK06702 391 DQRLAGVTSDLIRLSVGIEDVSDIIADLE 419
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
14-445 |
1.97e-96 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 295.26 E-value: 1.97e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 14 GFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFAS 93
Cdd:TIGR01328 3 TFATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 94 GQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVL 173
Cdd:TIGR01328 83 GMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFI-NMAIPEEVKAHIKDNTKIVYFETPANPTMKLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 174 DIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdGGKFDWSVERdgtpvfptfva 253
Cdd:TIGR01328 162 DMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLIC-GKAELLQQIR----------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 254 pdpayhglkyvdlgapafglkaRVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAG 333
Cdd:TIGR01328 230 ----------------------MVGIKDMTGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 334 LESSPWYPVKEKLGIEYtGSVLSFDLAvddtwSDEAQEKAwtFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLE 413
Cdd:TIGR01328 288 FEDHPGHDIAAKQMRMG-GGMITFELK-----GGFAGAKK--LLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEERE 359
|
410 420 430
....*....|....*....|....*....|..
gi 521255256 414 RAGINRATVRLSVGIENLEDILADLQLGFDAL 445
Cdd:TIGR01328 360 AAGITDGMIRLSVGLEDADDLIADLKQALDAL 391
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
8-444 |
3.91e-93 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 286.65 E-value: 3.91e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 8 SNVNNWGFASRAVHAGqTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVH 87
Cdd:PRK07504 4 EMARKWRPATRLVHSG-TLRSQFGETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAED 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 88 AVAFASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFAN 167
Cdd:PRK07504 83 ARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLV-DGLDLDNWEKAVRPNTKVFFLESPTN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 168 PQADVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFdwsVERdgtpv 247
Cdd:PRK07504 162 PTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAW---IEE----- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 248 fptfvapdpayHGLKYvdlgapafglkarvglLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVA 327
Cdd:PRK07504 234 -----------HLQDY----------------FRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 328 KVNYAGLESSPWYP-VKEKLGieyTGSVL-SFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHS 405
Cdd:PRK07504 287 RVIYPGRADHPQADiIAKQMT---GGSTLvAFEL-------KGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHK 356
|
410 420 430
....*....|....*....|....*....|....*....
gi 521255256 406 QSDRHGLERAGINRATVRLSVGIENLEDILADLQLGFDA 444
Cdd:PRK07504 357 NLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKK 395
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
11-446 |
3.36e-91 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 282.08 E-value: 3.36e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 11 NNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVA 90
Cdd:PRK07503 6 NNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 91 FASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQA 170
Cdd:PRK07503 86 LASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHV-DLTDPAALKAAISDKTRMVYFETPANPNM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 171 DVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdGGKFDWSVERdgtpvfpt 250
Cdd:PRK07503 165 RLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVV-GGKALADRIR-------- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 251 fvapdpaYHGLKyvDLgapafglkarvgllrdTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVN 330
Cdd:PRK07503 236 -------LEGLK--DM----------------TGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVH 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 331 YAGLESSPWYPVKEKlGIEYTGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRH 410
Cdd:PRK07503 291 YPGLPSFAQHALAQR-QMALPGGMIAFEL-------KGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPE 362
|
410 420 430
....*....|....*....|....*....|....*.
gi 521255256 411 GLERAGINRATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:PRK07503 363 ERAEHGISEGLVRLSVGLEDVADILADLAQALDACA 398
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
31-445 |
8.68e-89 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 275.80 E-value: 8.68e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 31 GARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAETAAILNLAGAGD 110
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 111 HIVTSARLYGGTETLFAvTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDIPTIAEVAHRNNVPLI 190
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFG-TLRGLGVEVTMV-DATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 191 VDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDWSverdGTP-VFPTFVAPDPAYHGLkyvdlgap 269
Cdd:PRK05939 166 VDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWS----AYPnIFPAYRKGDPQQWGL-------- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 270 afgLKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLESSPWYPVKEKLGIE 349
Cdd:PRK05939 234 ---TQIRKKGLRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRH 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 350 YtGSVLSFDLAVDDTWSDeaqekawtFIDALKLHSNLANIGDVRSLVVHPATTTHSQSdrhGLER---AGINRATVRLSV 426
Cdd:PRK05939 311 Y-GGLLSFELADGIDCFD--------FLNRLKLVIKATHLGDTRTLVIPVAPTIYYEM---GAERrasMGIADSLIRVSV 378
|
410
....*....|....*....
gi 521255256 427 GIENLEDILADLQLGFDAL 445
Cdd:PRK05939 379 GIEDEADLIADFEQALDAT 397
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
7-439 |
1.48e-87 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 272.29 E-value: 1.48e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 7 NSNVNNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFAledlgpvYSRLTNPTQEVLENRINSLEGGV 86
Cdd:PRK07811 5 SDHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRGGYE-------YARTGNPTRTALEEQLAALEGGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 87 HAVAFASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFA 166
Cdd:PRK07811 78 YGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPV-DLSDLDAVRAAITPRTKLIWVETPT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 167 NPQADVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGgkfdwsverdgtp 246
Cdd:PRK07811 157 NPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTN------------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 247 vfptfvapDPAyhglkyvdlgapafgLKARVGLLRDT-GATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPL 325
Cdd:PRK07811 224 --------DEE---------------LDEAFAFLQNGaGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPE 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 326 VAKVNYAGLESSPWYPVKEKLGIEYTGSVlSFDLAvddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHS 405
Cdd:PRK07811 281 VSTVLYPGLPSHPGHEVAARQMRGFGGMV-SVRLA-------GGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTHA 352
|
410 420 430
....*....|....*....|....*....|....
gi 521255256 406 QSDRHGLEragINRATVRLSVGIENLEDILADLQ 439
Cdd:PRK07811 353 STAGSQLE---VPDDLVRLSVGIEDVADLLADLE 383
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
15-445 |
8.03e-87 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 270.17 E-value: 8.03e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 15 FASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASG 94
Cdd:PRK06767 6 METALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 95 QAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFvEDADNPDAWAAAVQPNTKAFYGETFANPQADVLD 174
Cdd:PRK06767 86 MAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSF-CDMETEADIENKIRPNTKLIFVETPINPTMKLID 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 175 IPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdgGKFDwsverdgtpvfptfvap 254
Cdd:PRK06767 165 LKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTI--CKTR----------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 255 dpayhglkyvdlgapAFGLKARVgLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVnyagl 334
Cdd:PRK06767 226 ---------------ALAEKIRP-MRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGV----- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 335 esspWYPVKEKLG--IEYTGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGL 412
Cdd:PRK06767 285 ----WYPEGELASrqMKRGGGVISFSI-------KGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELR 353
|
410 420 430
....*....|....*....|....*....|...
gi 521255256 413 ERAGINRATVRLSVGIENLEDILADLQLGFDAL 445
Cdd:PRK06767 354 QEMGIYDNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
13-438 |
4.39e-86 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 268.91 E-value: 4.39e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 13 WGFASRAVHAGQtVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFA 92
Cdd:PRK07810 14 VSQATIGVRGGL-LRSGFEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 93 SGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADV 172
Cdd:PRK07810 93 SGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFV-DGEDLSQWEEALSVPTQAVFFETPSNPMQSL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 173 LDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGG-ILVDGGKFDWSVERdgtpvfptf 251
Cdd:PRK07810 172 VDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGaILGDREYIDGPVQK--------- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 252 vapdpayhglkyvdlgapafglkarvgLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNY 331
Cdd:PRK07810 243 ---------------------------LMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRY 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 332 AGLESSPWYPVKeKLGIEYTGSVLSFDLAVDDtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHG 411
Cdd:PRK07810 296 PFLPSHPQYDLA-KRQMSGGGTVVTFELDAPE---DAAKKRAFEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEG 371
|
410 420
....*....|....*....|....*..
gi 521255256 412 LERAGINRATVRLSVGIENLEDILADL 438
Cdd:PRK07810 372 RAAIGLGDGVVRLSVGLEDTDDLIADL 398
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
20-445 |
8.44e-80 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 251.55 E-value: 8.44e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 20 VHAGQTVDSDTGARNQPIYLTTAYvfnsaehaKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAeT 99
Cdd:PRK08247 10 AQIGNRSDERTGTVNPPVYFSTAY--------RHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAA-I 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 100 AAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNpDAWAAAVQPNTKAFYGETFANPQADVLDIPTIA 179
Cdd:PRK08247 81 QLVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASL-KAIEQAITPNTKAIFIETPTNPLMQETDIAAIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 180 EVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKfdwsverdgtpvfptfvapdpayh 259
Cdd:PRK08247 160 KIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQ------------------------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 260 glkyvdlgapafGLKARVGLLRD-TGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGlessp 338
Cdd:PRK08247 216 ------------ELCERLAYYQNaAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPG----- 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 339 wypvkeklgieyTGSVLSFDLavddtwsdeaQEKAW--TFIDALKLHSNLANIGDVRSLVVHPATTTHS---QSDRhgLE 413
Cdd:PRK08247 279 ------------RGGMLSFRL----------QDEEWvnPFLKSLKLITFAESLGGVESFITYPATQTHAdipEEIR--IA 334
|
410 420 430
....*....|....*....|....*....|..
gi 521255256 414 RAGINRaTVRLSVGIENLEDILADLQLGFDAL 445
Cdd:PRK08247 335 NGVCNR-LLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
17-443 |
1.31e-77 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 246.17 E-value: 1.31e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 17 SRAVHAGQTVDSDTGARNQPIYLTTAYvfnsaehaKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQA 96
Cdd:PRK07671 5 TKLIHGGIIGDPSTGAVSVPIYQVSTY--------KQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 97 AETAaILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDIP 176
Cdd:PRK07671 77 AITA-VMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFV-DTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 177 TIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdggkfdwsverdgtpvfptfVAPDP 256
Cdd:PRK07671 155 KISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVV--------------------VNSPE 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 257 AYHGLKYVDlgapafglkarvgllRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLES 336
Cdd:PRK07671 215 LAEDLHFVQ---------------NSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 337 SPWYPVKEKLGIEYtGSVLSFDLAvddtwsdeAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERAG 416
Cdd:PRK07671 280 HPNHELAKEQANGF-GGMISFDVG--------SEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELG 350
|
410 420
....*....|....*....|....*..
gi 521255256 417 INRATVRLSVGIENLEDILADLQLGFD 443
Cdd:PRK07671 351 ITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
12-446 |
1.00e-75 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 241.60 E-value: 1.00e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 12 NWGFASRAVHAGQTVDSDTGARNQPIYLTTAYvfnsaehakQRFALEDLGPV-YSRLTNPTQEVLENRINSLEGGVHAVA 90
Cdd:PRK08064 4 SYSIDTLLLHNQYKHDKQTGAVNVPIYHASTF---------HQFDFDTFGKYdYSRSGNPTREALEDIIAELEGGTKGFA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 91 FASGQAAETAAILNLAgAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQA 170
Cdd:PRK08064 75 FASGMAAISTAFLLLS-KGDHVLISEDVYGGTYRMITEVLSRFGIEHTFV-DMTNLEEVAQNIKPNTKLFYVETPSNPLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 171 DVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdggkfdwsverdgtpvfpt 250
Cdd:PRK08064 153 KVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAV------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 251 fvapdpayhgLKYVDLGapafglKARVGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVN 330
Cdd:PRK08064 214 ----------VKDEELA------QKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVY 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 331 YAGLESSPWYPVKEKLGiEYTGSVLSFDLavddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRH 410
Cdd:PRK08064 278 YPGLQTHLGFDIQQSQA-TSAGAVLSFTL--------QSEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKE 348
|
410 420 430
....*....|....*....|....*....|....*.
gi 521255256 411 GLERAGINRATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:PRK08064 349 ERDERGITDGLLRLSVGLENVDDLIADFEQALSYVE 384
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
15-446 |
3.99e-75 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 239.80 E-value: 3.99e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 15 FASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKqrfaledlGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASG 94
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPK--------GYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 95 QAAeTAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAwAAAVQPNTKAFYGETFANPQADVLD 174
Cdd:PRK06176 75 LAG-IHAVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQI-KKAIKPNTKALYLETPSNPLLKITD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 175 IPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKfdwsverdgtpvfptfvap 254
Cdd:PRK06176 153 LAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNE------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 255 dpayhglkyvdlgapafGLKARVGLLRDT-GATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAG 333
Cdd:PRK06176 214 -----------------ALAQEIAFFQNAiGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 334 LESSPWYPVKEKLGIEYTGsVLSFDLAVDdtwsdeaqEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLE 413
Cdd:PRK06176 277 LPTHPNHELAKKQMRGFSG-MLSFTLKND--------SEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQRE 347
|
410 420 430
....*....|....*....|....*....|...
gi 521255256 414 RAGINRATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:PRK06176 348 AAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG 380
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
11-446 |
2.37e-73 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 235.79 E-value: 2.37e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 11 NNWGFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVA 90
Cdd:PRK08249 5 NNAGVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 91 FASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNpDAWAAAVQPNTKAFYGETFANPQA 170
Cdd:PRK08249 85 FSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDH-EQIEAEIAKGCDLLYLETPTNPTL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 171 DVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdGGKfdwsverdgtpvfpt 250
Cdd:PRK08249 164 KIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVC-GSK--------------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 251 fvapdpayhglkyvdlgapafGLKARVGLLRD-TGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKV 329
Cdd:PRK08249 228 ---------------------ELMEQVYHYREiNGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAV 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 330 NYAGLESSPWYPVKeKLGIEYTGSVLSFDLAVDdtwsdeaQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDR 409
Cdd:PRK08249 287 YYPGLETHPNHEIA-KAQMRGFGGILSFVLKGG-------MDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTL 358
|
410 420 430
....*....|....*....|....*....|....*....
gi 521255256 410 HglERA--GINRATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:PRK08249 359 E--ERAalGIPEGLVRISVGIEDTEDLIADLEQAFAHLE 395
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
31-442 |
1.57e-69 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 225.09 E-value: 1.57e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 31 GARNQPIYLTTAYVFNSAEHakqrFALEDlgpvYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAeTAAILNLAGAGD 110
Cdd:TIGR01329 16 DASSMPIYQTATFKQPLAIE----NGPYD----YTRSGNPTRTALESLLAKLDKADRAFAFSSGMAA-LDVITRLLNNGD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 111 HIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDIPTIAEVAHRNNVPLI 190
Cdd:TIGR01329 87 EIIAGDDLYGGTDRLLTQVVPRSGVVVVHV-DTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 191 VDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGkfdwsvERDGTPVfptfvapdpayhglkyvdlgapA 270
Cdd:TIGR01329 166 VDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKG------EEIAKKV----------------------Y 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 271 FglkarvgLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLESSPWYpvkeKLGIEY 350
Cdd:TIGR01329 218 F-------LQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGF----HLHFSQ 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 351 T---GSVLSFdlavdDTWSDEAQEKawtFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERAGINRATVRLSVG 427
Cdd:TIGR01329 287 AkgaGSVLSF-----ETGSVALSKR---LVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVG 358
|
410
....*....|....*
gi 521255256 428 IENLEDILADLQLGF 442
Cdd:TIGR01329 359 IEDVDDLISDLDIAF 373
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
31-444 |
2.68e-68 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 223.40 E-value: 2.68e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 31 GARNQPIYLTTAYVFNSAEHAKQRF----------ALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAETA 100
Cdd:PRK07049 34 GAVKPPVFLTSTFVFRSAEDGRDFFdyvsgrkeppAGEGAGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 101 AILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPD-----AWAAAVQPNTKAFYGETFANPQADVLDI 175
Cdd:PRK07049 114 TLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFADGLSEAaigaaAEAAAAKGRVSLILIETPANPTNSLVDV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 176 PTIAEVA--------HRnnvPLIV-DNTIATAALVRPLELGADIVVASLTKfYTGNGSGlggiLVDGGKfdwsverdgtp 246
Cdd:PRK07049 194 AAVRRVAdaiearqgHR---PIIAcDNTLLGPVFQKPLEHGADLSVYSLTK-YVGGHSD----LVAGAV----------- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 247 vfptfvapdpayhglkyvdLGAPAfgLKARVGLLRDT-GATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPL 325
Cdd:PRK07049 255 -------------------LGRKA--LIRQVRALRSAiGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPK 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 326 VAKVNYAGlESSPWYPVKEKLGIEYT--GSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTT 403
Cdd:PRK07049 314 VEKLHYLP-FLDPDSAYGAVYKRQCTgaGSTFSFDI-------KGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMT 385
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 521255256 404 HSQSDRHGLERAGINRATVRLSVGIENLEDILADLQLGFDA 444
Cdd:PRK07049 386 HSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDA 426
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
36-438 |
9.72e-68 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 220.71 E-value: 9.72e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 36 PIYLTTAYVFNSAEHAKQR-FALEdlgpvYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAETAAILNLAGAGDHIVT 114
Cdd:PRK08574 23 PIYLTALFRQEGEAYPSDRgFDLK-----YSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLFFSLLKAGDRVVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 115 SARLYGGTETLfAVTLARLGIETTFVedadNPDAWA---AAVQPNTKAFYGETFANPQADVLDIPTIAEVAHRNNVPLIV 191
Cdd:PRK08574 98 PMEAYGTTLRL-LKSLEKFGVKVVLA----YPSTEDiieAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 192 DNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGK------FDWSverdgtpvfptfvapdpayhglkyvd 265
Cdd:PRK08574 173 DNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGefleelWEWR-------------------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 266 lgapafglkarvgllRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLESSPWYPVKEK 345
Cdd:PRK08574 227 ---------------RRLGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKR 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 346 L-GIEYTGSVLSFDLAvddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERAGINRATVRL 424
Cdd:PRK08574 292 LfGKDLYGGVVSFRVK-------GGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRL 364
|
410
....*....|....
gi 521255256 425 SVGIENLEDILADL 438
Cdd:PRK08574 365 SVGLEDVEDLIEDL 378
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
14-444 |
6.56e-64 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 210.91 E-value: 6.56e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 14 GFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFAS 93
Cdd:PRK06434 8 GFNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 94 GQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVE-DADNPDAWAAAvqpNTKAFYGETFANPQADV 172
Cdd:PRK06434 88 GMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDtDRLNSLDFDPS---NYDLIYAESITNPTLKV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 173 LDIPTIAEVAHRNNVplIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGK--FDWSVERDGTpvfpt 250
Cdd:PRK06434 165 PDIKNVSSFCHENDV--IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKsiFNNLVERRKT----- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 251 fvapdpayhglkyvdlgapafglkarvgllrdTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVN 330
Cdd:PRK06434 238 --------------------------------LGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVY 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 331 YAGLESSPwypvKEKLGIeytGSVLSFDLAVDdtwsdeaqEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRH 410
Cdd:PRK06434 286 YPDTEIGK----KVLRGF---GGMLSFELRSM--------EDVHKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPE 350
|
410 420 430
....*....|....*....|....*....|....
gi 521255256 411 GLERAGINRATVRLSVGIENLEDILADLQLGFDA 444
Cdd:PRK06434 351 ERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
32-442 |
6.64e-61 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 205.26 E-value: 6.64e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 32 ARNQPIYLTTAYvfnsaehaKQRFALEDlGPV-YSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAeTAAILNLAGAGD 110
Cdd:PLN02509 103 AMSTPLYQTATF--------KQPSAIEN-GPYdYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA-LSAVTHLIKNGE 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 111 HIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDIPTIAEVAHRNNVPLI 190
Cdd:PLN02509 173 EIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVL 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 191 VDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKfdwSVERDgtpvfptfvapdpayhglkyvdlgapa 270
Cdd:PLN02509 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE---KLAKE--------------------------- 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 271 fglkarVGLLRDT-GATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLESSPWYPVKEKLGiE 349
Cdd:PLN02509 302 ------VYFLQNSeGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQA-K 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 350 YTGSVLSFdlavdDTWSDEAQEKawtFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERAGINRATVRLSVGIE 429
Cdd:PLN02509 375 GAGSVFSF-----ITGSVALSKH---LVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIE 446
|
410
....*....|...
gi 521255256 430 NLEDILADLQLGF 442
Cdd:PLN02509 447 DVDDLISDLDIAF 459
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
16-438 |
2.64e-60 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 201.21 E-value: 2.64e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 16 ASRAVHAGqtVDSDTGARNQPIYLTTAYVFNSAEhaKQRfaledlgpvYSRLTNPTQEVLENRINSLEGGVHAVAFASGQ 95
Cdd:PRK06460 4 ATRTVRED--IDEATGAITTPIYQTTAYHYPEGE--KYR---------YSREANPTVLELTKKIVELENAEMGVAFSSGM 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 96 AAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTfVEDADNPDAWAAAVQPNTKAFYGETFANPQADVLDI 175
Cdd:PRK06460 71 GAISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVD-ASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 176 PTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFdwsverdgtpvfptfvapd 255
Cdd:PRK06460 150 TELSKVCKENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKL------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 256 payhgLKYVDLgapafglkarvgLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLE 335
Cdd:PRK06460 211 -----LNVIDQ------------MRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLK 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 336 SSPWYPVKEKLGIEYTGsVLSFDLAVDdtwsdeaQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERA 415
Cdd:PRK06460 274 SHVDYEIARRVLKGFGG-VLSFEVNGG-------QESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIV 345
|
410 420
....*....|....*....|...
gi 521255256 416 GINRATVRLSVGIENLEDILADL 438
Cdd:PRK06460 346 GITDSLLRLSVGIEDVNDLIEDL 368
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
16-442 |
5.85e-60 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 200.99 E-value: 5.85e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 16 ASRAVHAGqtVDSDT--GARNQPIYLTTAYVFNSAEHAKQRfaledlgpVYSRLTNPTQEVLENRINSLEGGVHAVAFAS 93
Cdd:PRK08776 14 ATAAVRAG--IDRDTayGAVTPPIVLSSNFSFDGFGNKRQY--------DYTRSGNPTRDLLGEALAELEGGAGGVITAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 94 GQAAETAAILNLAGAGDHIVTSARLYGGTETLFAvTLARLGIETTFVEDADNPDAWAAAVQPNTKAFYGETFANPQADVL 173
Cdd:PRK08776 84 GMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFN-ALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRIT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 174 DIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILvdggkfdwsverdgtpvfptfVA 253
Cdd:PRK08776 163 DLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAV---------------------VA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 254 PDPAYHglKYVDLGAPAFGLkarvgllrdtgaTLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAG 333
Cdd:PRK08776 222 RDAELH--QQLVWWANALGL------------TGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 334 LESSPWYPV--KEKLGIeytGSVLSFDLAvddtwSDEAQEKAwtFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHG 411
Cdd:PRK08776 288 LASHPGHALaaRQQKGF---GAMLSFELE-----GGEAAVRA--FVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEA 357
|
410 420 430
....*....|....*....|....*....|.
gi 521255256 412 LERAGINRATVRLSVGIENLEDILADLQLGF 442
Cdd:PRK08776 358 RAAAGISDGLLRLSVGIESAEDLLIDLRAGL 388
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
13-445 |
1.59e-57 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 193.67 E-value: 1.59e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 13 WGFASRAVHAGQTvdsdTGARNQPIYLTTayVFNSAEHAKqrfALEDLGP-VYSRLTNPTQEVLENRINSLEGGvHAVAF 91
Cdd:PRK07582 2 YGDGTRSVHAGGP----EAVPGEPVLPGP--VFAAPYHLS---PGEPTGPdTYGRASNPTWRALEAALGELEGA-EALVF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 92 ASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAWAAAVqpntKAFYGETFANPQAD 171
Cdd:PRK07582 72 PSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMAEAALAGA----DLVLAETPSNPGLD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 172 VLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGilvdggkfdwsverdgtpvfptF 251
Cdd:PRK07582 148 VCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLG----------------------Y 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 252 VAP-DPAyhglkyvdlgapafgLKARVGLLRD-TGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKV 329
Cdd:PRK07582 206 VAGrDPE---------------LMAAVERWRLlAGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 330 NYAGLESSPWYPVKEKLGIEYtGSVLSFDLAvddtwsdeAQEKAWTFIDALKLhsnlanigdvrslvVHPATT---THSQ 406
Cdd:PRK07582 271 RYPGLPGDPAHEVAARQMRRF-GGLVSFELA--------DAAAAERFVAASRL--------------VVAATSfggVHTS 327
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 521255256 407 SDRHGleRAG--INRATVRLSVGIENLEDILADLQLGFDAL 445
Cdd:PRK07582 328 ADRRA--RWGdaVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
36-444 |
1.71e-56 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 191.45 E-value: 1.71e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 36 PIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAETAAILNLAGAGDHIVTS 115
Cdd:PRK05968 29 PIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSFVEPGDRIVAV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 116 ARLYGGTETLFAVTLARLGIETTFVEDADnPDAWAAAVqPNTKAFYGETFANPQADVLDIPTIAEVAHRNNVPLIVDNTI 195
Cdd:PRK05968 109 RHVYPDAFRLFETILKRMGVEVDYVDGRD-EEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAALAKRHGVVTMIDNSW 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 196 ATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdggkfdwsverdgtpvfptfvapdpayhglkyvdlgapafGLKA 275
Cdd:PRK05968 187 ASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVA----------------------------------------GSKE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 276 RVGLLRD-----TGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLESSPwypvkeKLGIEY 350
Cdd:PRK05968 227 HIARINAeaypyLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP------PAGLSG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 351 TGSVLSFDLAVDdtwSDEAqekawTFIDALKLHSNLANIGDVRSLVVhPATTTHSQSDRHG-LERAGINRATVRLSVGIE 429
Cdd:PRK05968 301 TSGLFSFIFREG---IDVR-----AFADALKLFRLGVSWGGHESLVV-PAEVVLQQKAQPNsAARFGVSPRSVRLHVGLE 371
|
410
....*....|....*
gi 521255256 430 NLEDILADLQLGFDA 444
Cdd:PRK05968 372 GTEALWADLEQALAA 386
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
16-442 |
5.72e-55 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 187.41 E-value: 5.72e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 16 ASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSaehakqrfaledLGPV----YSRLTNPTQEVLENRINSLEGGVHAVAF 91
Cdd:PRK08861 7 ATIAVRTGIESDSQYHAVVPPIYLSTNYGFPA------------FGEVpkydYTRSGNPNRGLLEQTLSELESGKGAVVT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 92 ASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQAD 171
Cdd:PRK08861 75 NCGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFV-DQSDAAALDAALAKKPKLILLETPSNPLVR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 172 VLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFDwsverdgtpvfptf 251
Cdd:PRK08861 154 VVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEH-------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 252 vAPDPAYHGlkyvdlgapafglkarvgllRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNY 331
Cdd:PRK08861 220 -AEELAWWG--------------------NCIGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYH 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 332 AGLESSPWYPVKEKLGIEYtGSVLSFDLAvddtwsdEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHG 411
Cdd:PRK08861 279 PSLPEHPGHEIAKKQQSGF-GSMLSFEFA-------GSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEA 350
|
410 420 430
....*....|....*....|....*....|.
gi 521255256 412 LERAGINRATVRLSVGIENLEDILADLQLGF 442
Cdd:PRK08861 351 LAEAGVSQQLLRLSVGLEDAQDLIADLDQAF 381
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
16-446 |
2.10e-48 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 170.08 E-value: 2.10e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 16 ASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRfaledlgpVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQ 95
Cdd:PRK08045 6 ATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAH--------DYSRRGNPTRDVVQRALAELEGGAGAVLTNTGM 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 96 AAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDI 175
Cdd:PRK08045 78 SAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFV-DQGDEQALRAALAEKPKLVLVESPSNPLLRVVDI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 176 PTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILvdggkfdwsverdgtpvfptfVAPD 255
Cdd:PRK08045 157 AKICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVV---------------------IAKD 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 256 PAYhglkYVDLGAPAfglkarvgllRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLE 335
Cdd:PRK08045 216 PDV----VTELAWWA----------NNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 336 SSPWYPV--KEKLGIeytGSVLSFDLavddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLE 413
Cdd:PRK08045 282 ENQGHEIaaRQQKGF---GAMLSFEL-------DGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARA 351
|
410 420 430
....*....|....*....|....*....|...
gi 521255256 414 RAGINRATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:PRK08045 352 AAGISETLLRISTGIEDGEDLIADLENGFRAAN 384
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
31-428 |
1.07e-47 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 168.79 E-value: 1.07e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 31 GARNQPIYLTTAYVFNSAEHAKQRFALEdLGP-----VYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAETAAILNL 105
Cdd:PLN02242 33 GGVNMSIEASATFTVMEPDTMRRMFSGE-LGPdrdfyIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 106 AGAGDHIVTSARLYGGTETLFAVTLARL-GIETTFVeDADNPDAWAAAVQPN-TKAFYGETFANPQADVLDIPTIAEVAH 183
Cdd:PLN02242 112 CSSGGHVVASNTLYGGTHALLAHFLPRKcNITTTFV-DITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAH 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 184 RNNVPLIVDNTIAtAALVRPLELGADIVVASLTKFYTGNGSGLGGIlVDGgkfdwsverdgtpvfptfvapdPAyhglky 263
Cdd:PLN02242 191 EKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISGGADIIAGA-VCG----------------------PA------ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 264 vDLGAPAFGLKArvGLLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDAspLVAKVNYAGLESSPWYPVK 343
Cdd:PLN02242 241 -ELVNSMMDLHH--GALMLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKE--LGLKVIYPGLEDHPQHALL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 344 EKLGIE-Y-TGSVLSFDLavddtwsdEAQEKAWTFIDALKLHSNLA----NIGDVRSLVVHPATTTHSQSDRHGLERAGI 417
Cdd:PLN02242 316 KSMANKgYgFGGLLCLDM--------DTEERANRLMRYLQNSTQFGfmavSLGYYETLMSCSGSSTSSELDPEEKAAAGI 387
|
410
....*....|.
gi 521255256 418 NRATVRLSVGI 428
Cdd:PLN02242 388 SPGLVRMSVGY 398
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
21-439 |
2.14e-47 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 166.92 E-value: 2.14e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 21 HAGQTVDSDTGARNQPIYLTTAYvfnsaEHAKqrFAlEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQAAETA 100
Cdd:PRK07269 13 QAGIKSDEATGALVTPLHFSTTY-----QHPE--FG-QSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 101 AiLNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFvedADNPDAWAAAVQPNTKAFYGETFANPQADVLDIPTIAE 180
Cdd:PRK07269 85 A-FSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTY---ANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 181 VAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVdggkfdwsverdgtpvfptfVAPDPAYHG 260
Cdd:PRK07269 161 LAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVV--------------------TNDLELYEK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 261 LKYVdlgapafglkarvglLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLesspwy 340
Cdd:PRK07269 221 LFYN---------------LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK------ 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 341 pvkeklgieytGSVLSFDLAvddtwsdeAQEKAWTFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDRHGLERAGINRA 420
Cdd:PRK07269 280 -----------GGMISFKVA--------DETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDD 340
|
410
....*....|....*....
gi 521255256 421 TVRLSVGIENLEDILADLQ 439
Cdd:PRK07269 341 LLRLSIGIEDARDLIADLK 359
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
17-445 |
1.15e-40 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 149.26 E-value: 1.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 17 SRAVHAGQTVDSDTGARNQPIYLTTAYVFNSaeHAKQRFALEDLgpVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQA 96
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDS--HAAQRRAKGEL--TYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 97 AETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQADVLDIP 176
Cdd:TIGR01324 77 AVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYY-DPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 177 TIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGilvdggkfdwsverdgtpvfpTFVAPDP 256
Cdd:TIGR01324 156 AIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIG---------------------TVVANAR 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 257 AYHGLKYVdlgapafglkarvglLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLES 336
Cdd:TIGR01324 215 TWDQLREH---------------SYLMGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 337 SPWYPVKEKlgiEYTGS--VLSFDLAvddtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVH-PATTTHSQSDRHGLE 413
Cdd:TIGR01324 280 CPGHEFWKR---DFSGSsgLFSFVLQ------RLTQKQVHAFLDHLQLFGLGYSWGGYESLALCnQPELGHRPNIKRNLE 350
|
410 420 430
....*....|....*....|....*....|..
gi 521255256 414 RAGInratvRLSVGIENLEDILADLQLGFDAL 445
Cdd:TIGR01324 351 GPLI-----RVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
14-446 |
2.20e-38 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 143.41 E-value: 2.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 14 GFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEhakqrfALEDLGPVYSRLT--NPTQEVLENRINSLEGGVHAVAF 91
Cdd:PRK05967 12 GINTRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAE------TMATRGQKYTYGTrgTPTTDALCKAIDALEGSAGTILV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 92 ASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAwAAAVQPNTKAFYGETFANPQAD 171
Cdd:PRK05967 86 PSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGI-AKLMRPNTKVVHTEAPGSNTFE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 172 VLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGIlVDGGKFDWSVERDGTPVFPTF 251
Cdd:PRK05967 165 MQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGT-VSANEKCWPQLLEAHGTLGLC 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 252 VAPDPAYHGLKyvdlgapafglkarvgllrdtgatlspfnawitiqGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNY 331
Cdd:PRK05967 244 AGPDDTYQILR-----------------------------------GLRTMGIRLEHHRKSALEIARWLEGRPDVARVLH 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 332 AGLESSPWYPVKEKlgiEYTGS--VLSFDLAVDDtwsDEAQEKAWTFIDALKLHSNLANIGDVRSLVVHPattthSQSDR 409
Cdd:PRK05967 289 PALPSFPGHEIWKR---DFSGAsgIFSFVLAAGP---EKGKAKAHAFLDALEIFGLGYSWGGYESLALHV-----KLGDR 357
|
410 420 430
....*....|....*....|....*....|....*..
gi 521255256 410 HgLERAGINRATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:PRK05967 358 T-VAKAPYAGPVIRLQIGLEDVPDLKADLERGFAAAS 393
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
14-443 |
6.96e-38 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 141.79 E-value: 6.96e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 14 GFASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAE---HAKQRFALEDLgpVYSRLTNPTQEVLENRINSLEGGVHAVA 90
Cdd:PRK09028 4 KKATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAemrHAAKNRANGEM--FYGRRGTPTHFAFQAAIVELEGGAGTAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 91 FASGQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVeDADNPDAWAAAVQPNTKAFYGETFANPQA 170
Cdd:PRK09028 82 YPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYY-DPMIGEGIRELIRPNTKVLFLESPGSITM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 171 DVLDIPTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFdWSVERDGTPVFPT 250
Cdd:PRK09028 161 EVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKH-WDQLREHSYLMGQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 251 FVAPDPAYHGLKyvdlgapafglkarvgllrdtgatlspfnawitiqGLDTLALRVAKHNENAKAVAAVLDASPLVAKVN 330
Cdd:PRK09028 240 CTSPDDVYLAMR-----------------------------------GLRTLGVRLAQHEKNALKVANWLATRPEVDHVR 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 331 YAGLESSPWYPVKEKlgiEYTGS--VLSFDLAVDDTWSDEAqekawtFIDALKLHSNLANIGDVRSLVVH----PATTTH 404
Cdd:PRK09028 285 HPAFETCPGHEFFKR---DFSGSngLFSFVLKQGDPKAVTA------LVEGMQHFKMGFSWGGFESLILGvfgiNKLRTA 355
|
410 420 430
....*....|....*....|....*....|....*....
gi 521255256 405 SQSDRHGleraginrATVRLSVGIENLEDILADLQLGFD 443
Cdd:PRK09028 356 TNWDFSK--------PLIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
15-446 |
1.42e-36 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 138.30 E-value: 1.42e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 15 FASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPV-YSRLTNPTQEVLENRINSLEGGVHAVAFAS 93
Cdd:PRK08114 6 LDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKKHATRNRANGELfYGRRGTLTHFSLQEAMCELEGGAGCALYPC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 94 GQAAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAwAAAVQPNTKAFYGETFANPQADVL 173
Cdd:PRK08114 86 GAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADI-AKLIQPNTKVVFLESPGSITMEVH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 174 DIPTIAEVAHRNNvPLIV---DNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGILVDGGKFdWSVERDGTPVFPT 250
Cdd:PRK08114 165 DVPAIVAAVRSVN-PDAVimiDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARC-WEQLRENSYLMGQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 251 FVAPDPAYhglkyvdlgapafglkarvgllrdtgatlspfnawITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVN 330
Cdd:PRK08114 243 MVDADTAY-----------------------------------MTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVN 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 331 YAGLESSPWYpvkEKLGIEYTGSVLSFDLAVDDTWSDEAQEKawtFIDALKLHSNLANIGDVRSLVVhpatttHSQSDRH 410
Cdd:PRK08114 288 HPALPGCKGH---EFWKRDFTGSSGLFSFVLKKKLTDEQLAN---YLDNFSLFSMAYSWGGFESLIL------ANQPEEI 355
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 521255256 411 GLERAGINR----ATVRLSVGIENLEDILADLQLGFDALA 446
Cdd:PRK08114 356 AAIRPAGEVdftgTLIRLHIGLEDVDDLIADLAAGFARIV 395
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
16-439 |
3.32e-32 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 126.38 E-value: 3.32e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 16 ASRAVHAGQTVDSDTGARNQPIYLTTAYVFNSAEHAKQRFALEDLGPVYSRLTNPTQEVLENRINSLEGGVHAVAFASGQ 95
Cdd:PRK07050 11 QTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 96 AAETAAILNLAGAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADNPDAwAAAVQPNTKAFYGETFANPQADVLDI 175
Cdd:PRK07050 91 AAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGI-ADLIQPNTRLIWLEAPGSVTMEVPDV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 176 PTIAEVAHRNNVPLIVDNTIATAALVRPLELGADIVVASLTKFYTGNGSGLGGilvdggkfdwsverdgtpvfPTFVAPD 255
Cdd:PRK07050 170 PAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMG--------------------ATITADA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 256 PAYHGLKYVdlgapafglkarvglLRDTGATLSPFNAWITIQGLDTLALRVAKHNENAKAVAAVLDASPLVAKVNYAGLE 335
Cdd:PRK07050 230 ELHAKLKLA---------------RMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALP 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 336 SSPWYPVKEKlgiEYTGSVLSFDLAVDDTWSdeaQEKAWTFIDALKLHSNLANIGDVRSLVV---HPATTTHSQSDRHGL 412
Cdd:PRK07050 295 DCPGHAFWMR---DFTGAGGLFSVVFDERYS---PAQVDAFVEALELFAIGWSWGGACSLAMpydVASMRTAKWPHRGTL 368
|
410 420
....*....|....*....|....*..
gi 521255256 413 eraginratVRLSVGIENLEDILADLQ 439
Cdd:PRK07050 369 ---------VRLYIGLEDEADLIADLE 386
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
82-225 |
1.14e-10 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 60.09 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 82 LEGGVHAVAFASGQAAETAAILNLAGAGDHIVTSARLYGGTEtlfAVTLARLGIETTFVEDADNPDAWAAAVQ------- 154
Cdd:cd01494 14 QPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRY---WVAAELAGAKPVPVPVDDAGYGGLDVAIleelkak 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521255256 155 PNTKAFYGETFANPQADVLDIPTIAEVAHRNNVPLIVDNT----IATAALVRPLELGADIVVASLTKFYTGNGSG 225
Cdd:cd01494 91 PNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsaggASPAPGVLIPEGGADVVTFSLHKNLGGEGGG 165
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
75-193 |
4.95e-07 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 51.61 E-value: 4.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 75 LENRINSLEGGVHAVAFASGqaaeTAAILnLA------GAGDHIVTSARlyggteTLFAVTLA--RLGIETTFVE-DAD- 144
Cdd:COG0399 35 FEEEFAAYLGVKHAVAVSSG----TAALH-LAlralgiGPGDEVITPAF------TFVATANAilYVGATPVFVDiDPDt 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 521255256 145 ---NPDAWAAAVQPNTKA-----FYGetfaNPqadvLDIPTIAEVAHRNNVPLIVDN 193
Cdd:COG0399 104 yniDPEALEAAITPRTKAiipvhLYG----QP----ADMDAIMAIAKKHGLKVIEDA 152
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
84-192 |
4.23e-06 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 48.43 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 84 GGVHAVAFASGQAAETAAILNL-AGAGDHIVTSARLYGGTetlfAVTLARLGIETTFVE-DAD----NPDAWAAAVQPNT 157
Cdd:pfam01041 38 GVKHAIAVSSGTAALHLALRALgVGPGDEVITPSFTFVAT----ANAALRLGAKPVFVDiDPDtyniDPEAIEAAITPRT 113
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 521255256 158 KA-----FYGETFanpqadvlDIPTIAEVAHRNNVPLIVD 192
Cdd:pfam01041 114 KAiipvhLYGQPA--------DMDAIRAIAARHGLPVIED 145
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
141-225 |
1.19e-05 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 47.23 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 141 EDADNPDAWAAAVQ-PNTKAFYGEtfanpqadvlDIPTIAEVAHRNNVPLIVD-NTIATAALVRPLELGADIVVASLTKF 218
Cdd:cd00613 153 KEEVSEEVAALMVQyPNTLGVFED----------LIKEIADIAHSAGALVYVDgDNLNLTGLKPPGEYGADIVVGNLQKT 222
|
....*..
gi 521255256 219 YTGNGSG 225
Cdd:cd00613 223 GVPHGGG 229
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
133-228 |
2.49e-05 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 46.56 E-value: 2.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 133 LGIETTFVEDAD---NPDAWAAAVQPNTKAFYgetFANPQAD--VLDIPTIAEVAHRNNVPLIVD-NTIATAALVRPLEL 206
Cdd:COG0403 179 LGIEVVEVPDEDgvtDLEALKALLDDDVAGVL---VQYPNFFgvIEDLRAIAEAAHAAGALVIVAaDPLSLGLLKPPGEL 255
|
90 100
....*....|....*....|..
gi 521255256 207 GADIVVASLTKFytGNGSGLGG 228
Cdd:COG0403 256 GADIVVGEGQRL--GVPLGFGG 275
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
89-228 |
3.30e-05 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 45.83 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 89 VAFAS----GQAAETAAIL---NLAGAGDHIVTSARLYggTETLFAV-TLAR-LGIETTFVEDA-----DNPDAWAAAVQ 154
Cdd:pfam02347 127 IANASlldeGTAAAEAMALaarASKKKGKKFVVDKDVH--PQTLEVLkTRAKpFGIEIVEVDYTeegvtDLKDVFGVLVQ 204
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521255256 155 -PNTKAFygetfanpqadVLDIPTIAEVAHRNNVPLIV-DNTIATAALVRPLELGADIVVASLTKFytGNGSGLGG 228
Cdd:pfam02347 205 yPNTDGR-----------IEDYKELIELAHQRKSLVVVaADLLALTLLKPPGEFGADIAVGSAQRF--GVPLGYGG 267
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
87-223 |
7.01e-05 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 44.74 E-value: 7.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 87 HAVAFASGQaaeTAAIlNLA-------GAGDHIVTSARLYGGTETLFAVTLARLGIETTFVEDADN----PDAWAAAVQP 155
Cdd:COG0520 78 DEIIFTRGT---TEAI-NLVayglgrlKPGDEILITEMEHHSNIVPWQELAERTGAEVRVIPLDEDgeldLEALEALLTP 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 156 NTK--AF------YGEtfanpqadVLDIPTIAEVAHRNNVPLIVDntIATAALVRPL---ELGADIVVASLTKFY--TGN 222
Cdd:COG0520 154 RTKlvAVthvsnvTGT--------VNPVKEIAALAHAHGALVLVD--GAQSVPHLPVdvqALGCDFYAFSGHKLYgpTGI 223
|
.
gi 521255256 223 G 223
Cdd:COG0520 224 G 224
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
150-228 |
6.44e-04 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 42.05 E-value: 6.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 150 AAAV---QPNtkaFYGetfanpqadVL-DIPTIAEVAHRNNVPLIVD-NTIATAALVRPLELGADIVVA---SLtkfytG 221
Cdd:PRK00451 205 TAAVvvqYPN---FFG---------VIeDLEEIAEIAHAGGALFIVGvDPVSLGLLKPPGEYGADIVVGegqPL-----G 267
|
....*..
gi 521255256 222 NGSGLGG 228
Cdd:PRK00451 268 IPLSFGG 274
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
99-225 |
1.04e-03 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 41.30 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 99 TAAIlNLA--------GAGDHIVTS-----ARLyggtetlfaVTLARL----GIETTFVE-DAD---NPDAWAAAVQPNT 157
Cdd:cd06453 71 TEAI-NLVayglgranKPGDEIVTSvmehhSNI---------VPWQQLaertGAKLKVVPvDDDgqlDLEALEKLLTERT 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521255256 158 K--AFygeTFA-NPQADVLDIPTIAEVAHRNNVPLIVDNtiATAALVRPL---ELGADIVVASLTKFYTGNGSG 225
Cdd:cd06453 141 KlvAV---THVsNVLGTINPVKEIGEIAHEAGVPVLVDG--AQSAGHMPVdvqDLGCDFLAFSGHKMLGPTGIG 209
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
100-219 |
1.61e-03 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 40.40 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 100 AAILNLAGAGDHIVTSARLYGGTETLFAVTLARL-GIETTFVE-DADNPDAWAAAVQPNTKAFYGETFANPQADVLD--- 174
Cdd:cd00609 74 LLLRALLNPGDEVLVPDPTYPGYEAAARLAGAEVvPVPLDEEGgFLLDLELLEAAKTPKTKLLYLNNPNNPTGAVLSeee 153
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 521255256 175 IPTIAEVAHRNNVPLIVDNT---IATAALVRPLELGAD-----IVVASLTKFY 219
Cdd:cd00609 154 LEELAELAKKHGILIISDEAyaeLVYDGEPPPALALLDayervIVLRSFSKTF 206
|
|
| PRK07550 |
PRK07550 |
aminotransferase; |
89-194 |
3.57e-03 |
|
aminotransferase;
Pssm-ID: 181026 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521255256 89 VAFASG-QAAETAAILNLAGAGDHIVTSARLYGGTETlfavTLARLGIETTFVE-DADN-----PDAWAAAVQPNTKAFY 161
Cdd:PRK07550 93 VHITSGcNQAFWAAMVTLAGAGDEVILPLPWYFNHKM----WLDMLGIRPVYLPcDEGPgllpdPAAAEALITPRTRAIA 168
|
90 100 110
....*....|....*....|....*....|....*.
gi 521255256 162 GETFANPQADVLDIPTIAE---VAHRNNVPLIVDNT 194
Cdd:PRK07550 169 LVTPNNPTGVVYPPELLHElydLARRHGIALILDET 204
|
|
| |
