|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
6-603 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 1032.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 6 FFRSIHFKFTLIYVLLIIVAMQIIGVYFVNEMEKSLLKSYNDSLDQRVNNLSYYLEQEMTKDrsTSSSTTLKEDAERILN 85
Cdd:NF033092 1 FFRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSKE--DEDDETLEEDIRTILN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 86 DFSKEgEILEVSLIDKSYEVIATSNPYNREVAGKKTTEGIIKRTLLVGIPYENKFFDPERDSKVRISVTPIKKSNQETIG 165
Cdd:NF033092 79 DFNNN-DISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSSNGEVVG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 166 AIYVVASMDNVYNQIRTINTILASGTFIALGITAFLGIFVARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLAT 245
Cdd:NF033092 158 AIYIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 246 TFNYLTRELKEAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFED 325
Cdd:NF033092 238 AFNNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 326 LVEQQDSLLLEIEQEERTSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERREFVANVSHELRTPLTTMRSYLEAL 405
Cdd:NF033092 318 LLEEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEAL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 406 AEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSLIIERFEM-TKEQHVEFISNLPD 484
Cdd:NF033092 398 ADGAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFPK 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 485 RELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDvnEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRL 564
Cdd:NF033092 478 RDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLL--ETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKM 555
|
570 580 590
....*....|....*....|....*....|....*....
gi 521289351 565 GGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPY 603
Cdd:NF033092 556 GGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
180-613 |
4.28e-135 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 402.18 E-value: 4.28e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 180 IRTINTILASGTFIALGITAFLGIFVA------RTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATTFNYLTRE 253
Cdd:NF033093 2 IDNIKQNIFSFEFAFLLLLLGFILYFIllalrnRRDNKQLRQLNQKVKDLIAGDYSEVLDMQGDPELTELTNSLNDLSEV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 254 LKEAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSL 333
Cdd:NF033093 82 FRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREEALNMNILDLLDIDDEYDLRDLITKTPEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 334 LLEIEQEERTSV-LRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWQD 412
Cdd:NF033093 162 TLDSRDENGEFLsLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALSE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 413 PnIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSLIIERFEMTKEQH------VEFISNLPDRE 486
Cdd:NF033093 242 P-VAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFILNRFDQIKSQDtetgkkYEIVRDYPITS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 487 LYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEelLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGG 566
Cdd:NF033093 321 IWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQ--LIISISDEGLGIPKKDLPLIFDRFYRVDKARSRAQGG 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 521289351 567 TGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEE--QEDDWDE 613
Cdd:NF033093 399 TGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDavKDDEWED 447
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
288-606 |
1.28e-107 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 329.59 E-value: 1.28e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 288 IILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSLLLEIEQEERTSVLRVNFSVIQKEHGKIDGLIAVI 367
Cdd:COG5002 73 LLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 368 YDVTEQEQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKD 447
Cdd:COG5002 153 RDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 448 YQFNKEWIHFIRFFSLIIERFEMT-KEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDvnEE 526
Cdd:COG5002 233 LKLEKEPVDLAELLEEVVEELRPLaEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLR--EE 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 527 EELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEE 606
Cdd:COG5002 311 DDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
181-608 |
8.04e-87 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 276.46 E-value: 8.04e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 181 RTINTILASGTFIALGITAFLGIFVARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATTFNYLTRELKEAQSM 260
Cdd:COG5000 5 ILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 261 TEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEY-TFEDLVEQQDSLLLEIEQ 339
Cdd:COG5000 85 LEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAeLLREALERGWQEEIELTR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 340 EERTsVLRVNFSVIQkehgkIDGLIAVIYDVTEQEQidQER----REFVANVSHELRTPLTTMRSYLE----ALAEGAWQ 411
Cdd:COG5000 165 DGRR-TLLVRASPLR-----DDGYVIVFDDITELLR--AERlaawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 412 DPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDskdyQFNKEWIHFIRFFSLIIERFEMT-KEQHVEFISNLPDRELYVE 490
Cdd:COG5000 237 DREDLERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLPEVL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 491 IDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEelLYISVKDEGVGIPRKDMEKIFERFYrvdkarTRRLGGTGLG 570
Cdd:COG5000 313 ADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGR--VRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLG 384
|
410 420 430
....*....|....*....|....*....|....*...
gi 521289351 571 LAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQE 608
Cdd:COG5000 385 LAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
372-606 |
4.85e-84 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 262.92 E-value: 4.85e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 372 EQEQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFN 451
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 452 KEWIHFIRFFSLIIERFEMT-KEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITfsVDVNEEEELL 530
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTIT--ISARREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521289351 531 YISVKDEGVGIPRKDMEKIFERFYRVDkaRTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEE 606
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
271-602 |
8.33e-76 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 244.82 E-value: 8.33e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 271 VIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSLLLEIEQEERTSVLRVNF 350
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 351 SVIQKEHGKIDGLIAVIYDVTEQEQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAwqDPNIApRFLNVTQNETERM 430
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQR-EYLETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 431 IRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSLIIERFE-MTKEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALK 509
Cdd:COG0642 158 LRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 510 YSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRrlGGTGLGLAIAKEMVQAHGGDIWADS 589
Cdd:COG0642 238 YTPEGGTVT--VSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVES 313
|
330
....*....|...
gi 521289351 590 IEGKGTTITFTLP 602
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
272-601 |
2.99e-74 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 240.96 E-value: 2.99e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 272 IAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDeytFEDLVEQQDS----LLLEIEQEERTSVLR 347
Cdd:TIGR02966 12 AQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPE---FVEYLAAGRFseplELPSPINSERVLEIR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 348 VNfsviqkeHGKIDGLIAVIYDVTEQEQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWQDPNIAPRFLNVTQNET 427
Cdd:TIGR02966 89 IA-------PYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 428 ERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSLIIERFEMT---KEQHVEFISnlpDRELYVEIDPDKITQVLDNII 504
Cdd:TIGR02966 162 QRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALsqgKNHQITFEI---DGGVDVLGDEDELRSAFSNLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 505 SNALKYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGD 584
Cdd:TIGR02966 239 SNAIKYTPEGGTIT--VRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHAR 316
|
330
....*....|....*..
gi 521289351 585 IWADSIEGKGTTITFTL 601
Cdd:TIGR02966 317 LEIESELGKGSTFSFIF 333
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
6-606 |
1.31e-63 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 220.61 E-value: 1.31e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 6 FFRSIHFKFTLIYVLLIIVAMQIIGVYFVNEMEKSLLksynDSLDQRVNNLSYYLEQEMTKD-----RSTSSSTTLKEDA 80
Cdd:PRK11360 2 YPRSFRNQLILLVILLVIVPTLLIGYILETEGRSAVL----SEKEKKLSAVVNLLDQALGGRfdlylASQGVADLPREEK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 81 ERILN--------DFSKEGEILEVSLIDKSYEVIATSNP---YNREVAGKKTTEGIIKRTLLVGIPYEnKFFDPERDSKV 149
Cdd:PRK11360 78 IRALNaelapvteNITHAYPGIGAGYYSKELDAIITYGPsalYQENVGVRIKADHPGREVMRTNTPLV-ESGGQVRGGIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 150 RISVtPIKKsNQETIGAIYVVASMDNVYNQI----RTINTILASGTFIALGIT-AFLGIFVA--RTITHPLSDMRKqaie 222
Cdd:PRK11360 157 NSMI-PIER-NGEVIGYIWANELTEDIRRQAwkmdRRIYAVLAAGLVIGLLLIfLLSRRFSAnvDIIKDGLSTLEN---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 223 lakgNFSRKVRKYgNDEIGQLATTFNYLTRELKEAQSMTEgerkklsSVIAYMTDGVIATNRNGAIILLNTPALELLNVS 302
Cdd:PRK11360 231 ----DLSTRLPPL-PGELGEISQAINNLAQALRETRSLNE-------LILESIADGVIAIDRQGKITTMNPAAEVITGLQ 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 303 RETALEMPITSLLG--------LEDeyTFEDLVEQQDsLLLEIEQEERTSVLRVNFSVIQKEHGKIDGLIAVIYDVTE-- 372
Cdd:PRK11360 299 RHELVGKPYSELFPpntpfaspLLD--TLEHGTEHVD-LEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTErk 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 373 --QEQIDQERR-----EFVANVSHELRTPLTTMRSYLEALAEGAwqDPNIAPRFLNVTQNETERMIRLVNDLLQLSK--- 442
Cdd:PRK11360 376 rlQRRVARQERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQLLEFSRpre 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 443 --FDSKDYQFNKEwiHFIRFFSLIIERFEMTKEqhVEFISNLPDrelyVEIDPDKITQVLDNIISNALKYSPEGGHITFS 520
Cdd:PRK11360 454 sqWQPVSLNALVE--EVLQLFQTAGVQARVDFE--TELDNELPP----IWADPELLKQVLLNILINAVQAISARGKIRIR 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 521 VDVNEEEELlYISVKDEGVGIPRKDMEKIFERFYrvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFT 600
Cdd:PRK11360 526 TWQYSDGQV-AVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLY 598
|
....*.
gi 521289351 601 LPYKEE 606
Cdd:PRK11360 599 LPINPQ 604
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
264-610 |
8.60e-60 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 203.54 E-value: 8.60e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 264 ERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYT--FEDLVEQQDSL------LL 335
Cdd:COG3852 5 SEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVterevtLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 336 EIEQEERTsvLRVNFSVIQKEHGKiDGLIAVIYDVTEQEQIDQERR---------EFVANVSHELRTPLTTMRSYLEALA 406
Cdd:COG3852 85 RKDGEERP--VDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 407 EGAwqDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQ-FNkewIHFI--RFFSLIIERFEMTKEQHVEFISNLP 483
Cdd:COG3852 162 REL--PDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREpVN---LHEVleRVLELLRAEAPKNIRIVRDYDPSLP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 484 DrelyVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEEL--------LYISVKDEGVGIPRKDMEKIFERFYr 555
Cdd:COG3852 237 E----VLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyVRIEVIDNGPGIPEEILDRIFEPFF- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 521289351 556 vdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDD 610
Cdd:COG3852 312 -----TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
238-604 |
3.09e-50 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 181.33 E-value: 3.09e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 238 DEIGQLATTFNYLTRELKEAQSMTEgeRKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGL 317
Cdd:COG5809 115 DIEGMLAISRDITERKRMEEALRES--EEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHS 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 318 EDEYTFEDLVEQ--QDSLLLEIE-----QEERTSVLRVNFSVIqKEHGKIDGLIAVIYDVTEQEQIDQERR--------- 381
Cdd:COG5809 193 DDQENVAAFISQllKDGGIAQGEvrfwtKDGRWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEELLRkseklsvvg 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 382 EFVANVSHELRTPLTTMRSYLEALAEGAWQDPNiapRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFnkewIHFIRFF 461
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKYEP----KDLNTLI 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 462 SLIIERFEMTK-EQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVnEEEELLYISVKDEGVG 540
Cdd:COG5809 345 EEVIPLLQPQAlLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA-EDDDKVVISVTDEGCG 423
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521289351 541 IPRKDMEKIFERFYrvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYK 604
Cdd:COG5809 424 IPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
372-602 |
9.60e-48 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 174.97 E-value: 9.60e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 372 EQEQIDQERREFVANVSHELRTPLTTMRSYLEALAE--GAWQDPNiAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQ 449
Cdd:COG4251 274 ELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEdyGDKLDEE-GREYLERIRDAAERMQALIDDLLAYSRVGRQELE 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 450 FnkEWIHFIRFFSLIIERFEMT-KEQHVEF-ISNLPDrelyVEIDPDKITQVLDNIISNALKYSPEG--GHITFSVDVNE 525
Cdd:COG4251 353 F--EPVDLNELLEEVLEDLEPRiEERGAEIeVGPLPT----VRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREG 426
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521289351 526 EEelLYISVKDEGVGIPRKDMEKIFERFYRVDkaRTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:COG4251 427 GE--WVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
265-602 |
8.59e-47 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 170.19 E-value: 8.59e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 265 RKKLSSVI-------AYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDeytFEDLVEQQD-SLLLE 336
Cdd:PRK11006 90 RRELGNLIkrfrsgaESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPE---FTQYLKTRDfSRPLT 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 337 IE-QEERTsvlrVNFSVIQKEHGKidgLIAVIYDVTEQEQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWQDPnI 415
Cdd:PRK11006 167 LVlNNGRH----LEIRVMPYTEGQ---LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-L 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 416 APRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSlIIERFEMT---KEQHVEFISnlpDRELYVEID 492
Cdd:PRK11006 239 REKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLR-VLEREAQTlsqGKHTITFEV---DNSLKVFGN 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 493 PDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEELLyiSVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLA 572
Cdd:PRK11006 315 EDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEF--SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLA 392
|
330 340 350
....*....|....*....|....*....|
gi 521289351 573 IAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:PRK11006 393 IVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
277-602 |
7.61e-43 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 157.65 E-value: 7.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 277 DGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSLLLEIEQEERTSVLRVNFSVIQKE 356
Cdd:COG4191 26 LLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 357 HGKIDGLIAviyDVTEQEQIDQERR----------------EFVANVSHELRTPLTTMRSYLEALAE--GAWQDPNIAPR 418
Cdd:COG4191 106 NAELEELER---DITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELRE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 419 FLNVTQNETERMIRLVNDLLQLSKFDSKDyqfnKEWI---HFIRFFSLIIERfeMTKEQHVEFISNLPDRELYVEIDPDK 495
Cdd:COG4191 183 ALERILEGAERAAEIVRSLRAFSRRDEEE----REPVdlnELIDEALELLRP--RLKARGIEVELDLPPDLPPVLGDPGQ 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALKYSPEG--GHITFSVDVNEEEelLYISVKDEGVGIPRKDMEKIFERFYRvdkarTRRLG-GTGLGLA 572
Cdd:COG4191 257 LEQVLLNLLINAIDAMEEGegGRITISTRREGDY--VVISVRDNGPGIPPEVLERIFEPFFT-----TKPVGkGTGLGLS 329
|
330 340 350
....*....|....*....|....*....|
gi 521289351 573 IAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
373-602 |
4.44e-41 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 155.95 E-value: 4.44e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 373 QEQIDQ-------ERReFVANVSHELRTPLTTMRSYLEALAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDS 445
Cdd:NF040691 258 QRQIRQleelsrlQQR-FVSDVSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDA 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 446 KDYQFNKEWIHFIRFFSLIIERFEMTKEQH-VEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSpEGGHITFSVDVN 524
Cdd:NF040691 337 GAAELDVEPVDLRPLVRRVVDALRQLAERAgVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQD 415
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521289351 525 EEEelLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:NF040691 416 DTA--VAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
491-604 |
4.76e-41 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 144.33 E-value: 4.76e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 491 IDPDKITQVLDNIISNALKYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKaRTRRLGGTGLG 570
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRIT--VTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|....
gi 521289351 571 LAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYK 604
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
496-601 |
2.44e-40 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 142.36 E-value: 2.44e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALKYSPEGGHITFSVDvnEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRrlGGTGLGLAIAK 575
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLR--QEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVR 76
|
90 100
....*....|....*....|....*.
gi 521289351 576 EMVQAHGGDIWADSIEGKGTTITFTL 601
Cdd:cd00075 77 RIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
374-610 |
2.67e-40 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 153.25 E-value: 2.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 374 EQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWQdpnIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKE 453
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK---FTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 454 WIHFIRFFSLII----ERFEmTKEQHVEFisNLPDrELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVdvNEEEEL 529
Cdd:PRK10549 311 PVDLVPLLEVAGgafrERFA-SRGLTLQL--SLPD-SATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISA--EQRDKT 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 530 LYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQED 609
Cdd:PRK10549 385 LRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQR 464
|
.
gi 521289351 610 D 610
Cdd:PRK10549 465 E 465
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
373-602 |
5.16e-40 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 150.49 E-value: 5.16e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 373 QEQID-QERreFVANVSHELRTPLTTMRSYLEALAEGAWQDPNIAP-----RFLNVTQNETERMIRLVNDLLQLSKFDSK 446
Cdd:PRK09303 145 LEQLKfKDR--VLAMLAHDLRTPLTAASLALETLELGQIDEDTELKpalieQLQDQARRQLEEIERLITDLLEVGRTRWE 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 447 DYQFNKEWIHFIRFFSLIIERFEMT-KEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVdVNE 525
Cdd:PRK09303 223 ALRFNPQKLDLGSLCQEVILELEKRwLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSM-LHR 301
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521289351 526 EEELLYISVKDEGVGIPRKDMEKIFERFYRVDkaRTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:PRK09303 302 TTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
498-602 |
1.08e-38 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 138.01 E-value: 1.08e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 498 QVLDNIISNALKYSPEGgHITFSVDVNEEEE---LLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIA 574
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-EVTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 521289351 575 KEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
374-602 |
2.68e-38 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 147.28 E-value: 2.68e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 374 EQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWQdpnIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKE 453
Cdd:NF012163 234 EKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRK---FTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKA 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 454 WIHFIRFFSLIIERFEMTKEQH-VEFISNLPDRELYVEiDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEELLYi 532
Cdd:NF012163 311 SVDLVPLLEVEGGAFRERFASAgLELEVSLPDSSLVFG-DRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLT- 388
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 533 sVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:NF012163 389 -VADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
492-605 |
9.71e-36 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 129.80 E-value: 9.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 492 DPDKITQVLDNIISNALKYSPEGGHITFSVdvnEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKartRRLGGTGLGL 571
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|....
gi 521289351 572 AIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKE 605
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
374-602 |
1.34e-34 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 136.75 E-value: 1.34e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 374 EQIDQERREFVANVSHELRTPLTTmrsyLEALAEGAWQDPNIAPRF---LNVTQNETERMIRLVNDLLQLSKFDS----- 445
Cdd:TIGR01386 235 EDAFQRLSQFSADLAHELRTPLTN----LLGQTQVALSQPRTGEEYrevLESNLEELERLSRMVSDMLFLARADNgqlal 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 446 --KDYQFNKEWIHFIRFFSLIIErfEMTKEQHVEfisnlpdRELYVEIDPDKITQVLDNIISNALKYSPEGGHITfsVDV 523
Cdd:TIGR01386 311 erVRLDLAAELAKVAEYFEPLAE--ERGVRIRVE-------GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTIT--VRI 379
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521289351 524 NEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKgTTITFTLP 602
Cdd:TIGR01386 380 ERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
235-602 |
4.72e-34 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 135.63 E-value: 4.72e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 235 YGNDEIGQLATTFNYltrELKEAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSL 314
Cdd:COG5805 129 NQNGQAAILALRDIT---KKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLEL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 315 LGLEDEYTF----EDLVEQQDSLLLE---IEQEERTSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERR------ 381
Cdd:COG5805 206 LHPCDKEEFkeriESITEVWQEFIIEreiITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArsekls 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 382 ---EFVANVSHELRTPLTTMRSYLEALAEGAWQDPNiaprFLNVTQNETERMIRLVNDLLQLSKFDSkdYQFNKEWIHFI 458
Cdd:COG5805 286 iagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEE----YFDIMLSELDRIESIISEFLALAKPQA--VNKEKENINEL 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 459 --RFFSLiierfeMTKE---QHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDvnEEEELLYIS 533
Cdd:COG5805 360 iqDVVTL------LETEailHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTE--EEDNSVIIR 431
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521289351 534 VKDEGVGIPRKDMEKIFERFYrvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:COG5805 432 VIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
297-602 |
2.72e-33 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 136.45 E-value: 2.72e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 297 ELLNVSRETALEMPItslLGLEDEYTFEDLVEQQDSLLLEIE---QEERTSVLRVNFSViqKEHGKIDgliaviydvTEQ 373
Cdd:TIGR02956 392 RAIEAFRDTAAHNLK---LQADERQVAQELQEHKESLEQLVAqrtQELAETNERLNAEV--KNHAKAR---------AEA 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 374 EQIDQERREFVANVSHELRTPLTTMRSYLEALAEGawQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKE 453
Cdd:TIGR02956 458 EEANRAKSAFLATMSHEIRTPLNGILGTLELLGDT--GLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPR 535
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 454 WIHFIRFFSLIIERFEM-TKEQHVEFISNLPDR-ELYVEIDPDKITQVLDNIISNALKYSPEgGHITFSVDVNEEEELLy 531
Cdd:TIGR02956 536 PFDLNALLDDVHHLMVSrAQLKGIQLRLNIPEQlPNWWQGDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDDSSLL- 613
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 521289351 532 ISVKDEGVGIPRKDMEKIFERFYRVDKarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:TIGR02956 614 FEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-602 |
4.70e-33 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 122.05 E-value: 4.70e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALKYSPEGGHITFSVDVNEeeelLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAK 575
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQ----WTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*..
gi 521289351 576 EMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
378-602 |
5.20e-32 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 129.28 E-value: 5.20e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 378 QERreFVANVSHELRTPLTTMRSYLeALA-----EGawqdpniapRFLNVTQNETERMIRLVNDLLQLSKFDSKDyQFNK 452
Cdd:PRK09470 243 QQR--LLSDISHELRTPLTRLQLAT-ALLrrrqgES---------KELERIETEAQRLDSMINDLLVLSRNQQKN-HLER 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 453 EWIHFIRFFSLIIE--RFEMTKEQHVEFISNLPDReLYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEeeelL 530
Cdd:PRK09470 310 ETFKANSLWSEVLEdaKFEAEQMGKSLTVSAPPGP-WPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDG----L 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521289351 531 YISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWA-DSIEGkGTTITFTLP 602
Cdd:PRK09470 385 TITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLP 456
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
371-609 |
3.81e-31 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 129.77 E-value: 3.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 371 TEQEQIdqeRREFVANVSHELRTPLTTMRSYLEAL-----AEG---AWQDPNIAPRFLNVTqnetermiRLVNDLLQLSK 442
Cdd:PRK10490 658 SEREQL---RNALLAALSHDLRTPLTVLFGQAEILtldlaSEGsphARQASEIRQQVLNTT--------RLVNNLLDMAR 726
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 443 FDSKDYQFNKEWIHFIRFFSLIIERFE-MTKEQHVEFisNLPDRELYVEIDPDKITQVLDNIISNALKYSpeGGHITFSV 521
Cdd:PRK10490 727 IQSGGFNLRKEWLTLEEVVGSALQMLEpGLSGHPINL--SLPEPLTLIHVDGPLFERVLINLLENAVKYA--GAQAEIGI 802
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 522 DVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTrrLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTL 601
Cdd:PRK10490 803 DAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTL 880
|
250
....*....|....
gi 521289351 602 PYK------EEQED 609
Cdd:PRK10490 881 PLEtppeleEFHED 894
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
385-610 |
1.51e-30 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 124.90 E-value: 1.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 385 ANVSHELRTPLTTMRSYLEALAEGA---WQDPNIAprflNVTQNETERMIRLVNDLLQLSKFDSKDYQ---FNKEWIHFI 458
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAERApagGEAHQLA----QVMAKEADRLNRVVSELLELVKPTHLALQavdLNDLINHSL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 459 RffslIIERFEMTKEQHVEFISNlPDRELyVEIDPDKITQVLDNIISNALKYSPEGGHITFSVdvNEEEELLYISVKDEG 538
Cdd:PRK10364 318 Q----LVSQDANSREIQLRFTAN-DTLPE-IQADPDRLTQVLLNLYLNAIQAIGQHGVISVTA--SESGAGVKISVTDSG 389
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521289351 539 VGIPRKDMEKIFERFYrvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDD 610
Cdd:PRK10364 390 KGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDP 455
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
358-602 |
8.47e-30 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 125.05 E-value: 8.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 358 GKIDGLIAVIYDVTE----QEQIDQERRE---FVANVSHELRTPL------TTM----------RSYLEALAEGAWQDPN 414
Cdd:PRK11091 254 GKRHGLMGFGRDITErkryQDALEKASRDkttFISTISHELRTPLngivglSRIlldteltaeqRKYLKTIHVSAITLGN 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 415 IaprflnvtqnetermirlVNDLLQLSKFDSKDYQFNKEWIHFIRFFS-------LIIE----RFEMTKEQHvefisnLP 483
Cdd:PRK11091 334 I------------------FNDIIDMDKMERRKLQLDNQPIDFTDFLAdlenlsgLQAEqkglRFDLEPLLP------LP 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 484 DrelYVEIDPDKITQVLDNIISNALKYSPEGGhITFSVdVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRV-DKARTR 562
Cdd:PRK11091 390 H---KVITDGTRLRQILWNLISNAVKFTQQGG-VTVRV-RYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGK 464
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 521289351 563 RLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:PRK11091 465 PATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
383-602 |
1.03e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 119.56 E-value: 1.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 383 FVANVSHELRTPLTTMRSYLEALAEGAwqDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFS 462
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 463 LIIERFEMTKEQ-HVEFISNLPDreLYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEelLYISVKDEGVGI 541
Cdd:PRK11100 337 ELVEAREAQAAAkGITLRLRPDD--ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQ--VALSVEDQGPGI 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521289351 542 PRKDMEKIFERFY---RVDKARTrrlgGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:PRK11100 413 PDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
363-602 |
1.42e-28 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 119.49 E-value: 1.42e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 363 LIAVIYDV-TEQEQidqerreFVANVSHELRTPLTTMRSYLE-ALAEgawqdpniaprflNVTQNETE-----------R 429
Cdd:PRK09835 251 MIERIEDVfTRQSN-------FSADIAHEIRTPITNLITQTEiALSQ-------------SRSQKELEdvlysnleeltR 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 430 MIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSLIIERFE-MTKEQHVEFisNLPDRELYVEIDPDKITQVLDNIISNAL 508
Cdd:PRK09835 311 MAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEaWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNAL 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 509 KYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWAD 588
Cdd:PRK09835 389 RYTPAGEAIT--VRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVT 466
|
250
....*....|....
gi 521289351 589 SiEGKGTTITFTLP 602
Cdd:PRK09835 467 S-DARGTRFVISLP 479
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-602 |
1.02e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 107.55 E-value: 1.02e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 492 DPDKITQVLDNIISNALKYSPEGGhiTFSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGL 571
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGG--KLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 521289351 572 AIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
380-602 |
1.92e-27 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 115.47 E-value: 1.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 380 RREFVANVSHELRTPLTTMRSYLEALAegawqdpniaprflNVTQNETERMIR-------LVNDLLQLSKFDSKDYQFNK 452
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLEMSD--------------NLSAAESQALNRdigqleaLIEELLTYARLDRPQNELHL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 453 EWIHFIRFFSLIIERFEMTkEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSpeGGHITFSVDVNEEEELLyi 532
Cdd:PRK10604 278 SEPDLPAWLSTHLADIQAV-TPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACL-- 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 533 SVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:PRK10604 353 IVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-602 |
7.18e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 104.98 E-value: 7.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 502 NIISNALKYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAH 581
Cdd:cd16952 7 NLVSNAVKYTPPSDTIT--VRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 521289351 582 GGDIWADSIEGKGTTITFTLP 602
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
335-583 |
1.16e-26 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 111.60 E-value: 1.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 335 LEIEQEERTSVlrvNFSVIQkEHGKIDGLIAVIYDVTE-----QEQIDQERrEFVANVSHELRTPLTTMRSYLEALAEGA 409
Cdd:PRK10755 92 LQKELEARTAD---NLTPIA-IHSSTLEIEAVTSALNQlvsrlTSTLDQER-LFTADVAHELRTPLAGIRLHLELLEKQH 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 410 WQD--PNIAprflnvtqnETERMIRLVNDLLQLS----KFDSKDYQfNKEWIHFIrFFSLIIERFEMTKEQHVEFISNLP 483
Cdd:PRK10755 167 HIDvaPLIA---------RLDQMMHTVEQLLQLAragqSFSSGHYQ-TVKLLEDV-ILPSQDELSEMLEQRQQTLLLPES 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 484 DRELYVEIDPDKITQVLDNIISNALKYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDkartRR 563
Cdd:PRK10755 236 AADITVQGDATLLRLLLRNLVENAHRYSPEGSTIT--IKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SR 309
|
250 260
....*....|....*....|
gi 521289351 564 LGGTGLGLAIAKEMVQAHGG 583
Cdd:PRK10755 310 YGGIGLGLSIVSRITQLHHG 329
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
380-608 |
1.16e-26 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 115.99 E-value: 1.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 380 RREFVANVSHELRTPLTTMRSYLEALAeGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIR 459
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 460 FFSLIIERF---EMTKEQHVEFISNLPDRELyVEIDPDKITQVLDNIISNALKYSPEGG-HITFS-VDVNEEEELLYISV 534
Cdd:PRK09959 791 LVQNTCHSFgaiAASKSIALSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSlGHIDDNHAVIKMTI 869
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521289351 535 KDEGVGIPRKDMEKIFERFYRVDKARTRRlgGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQE 608
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQ 941
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
240-606 |
5.13e-26 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 110.32 E-value: 5.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 240 IGQLATTFNYLTRELKEAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSretALEMPITSLLgled 319
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD---AIGRPIDEVL---- 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 320 eytfedlVEQQDSLLLEIEQEERTSVLRVNFSVIqKEHGKIDGLIAVIYDVTEQEQIDQE---RREFVANV---SHELRT 393
Cdd:COG3290 131 -------AEVLETGERDEEILLNGRVLVVNRVPI-RDDGRVVGAVATFRDRTELERLEEElegVKELAEALraqRHDFRN 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 394 PLTTMRSYLEalaegawqdpniaprflnvtQNETERMIRLVNDLlqlskfdSKDYQfnkEWIHFIRFF-------SLIIE 466
Cdd:COG3290 203 HLHTISGLLQ--------------------LGEYDEALEYIDEI-------SEELQ---ELIDSLLSRignpvlaALLLG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 467 RFEMTKEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKY--SPEGGHITFSVDVNEEEELLYISVKDEGVGIPRK 544
Cdd:COG3290 253 KAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEE 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521289351 545 DMEKIFERFYRvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEE 606
Cdd:COG3290 333 LLEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
492-602 |
7.78e-26 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 102.19 E-value: 7.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 492 DPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEELLyISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGL 571
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFL-LTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 521289351 572 AIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-602 |
1.59e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 100.86 E-value: 1.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALKYSPEGGHITFSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKarTRRLGGTGLGLAIAK 575
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 521289351 576 EMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
385-585 |
2.27e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 107.77 E-value: 2.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 385 ANVSHELRTPLTTMRSYLEALAEGAWQ-DPNIAPRFLnvtqNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSL 463
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEpDPALFKSLL----NQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 464 IIERFEMTKEQ-HVEFISNLPDRELYVeiDPDKITQVLDNIISNALKYSpEGGHITFSVDVNEEEELLYIsvKDEGVGIP 542
Cdd:NF012226 219 VLKMFEDRLEQaQLTIVLNLTATPVFC--DRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQI--EDEGPGIA 293
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 521289351 543 RKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDI 585
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
371-602 |
3.61e-25 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 110.83 E-value: 3.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 371 TEQEQIDQERREFVANVSHELRTPLTTMRSYLEALAEGAWqdPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKdyqf 450
Cdd:PRK10841 438 QAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKEL--PKGVDRLVTAMNNSSSLLLKIISDILDFSKIESE---- 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 451 nkewihfirffSLIIERFEMTKEQHVEFISN--LP-----DRELYVEIDPD----------KITQVLDNIISNALKYSPE 513
Cdd:PRK10841 512 -----------QLKIEPREFSPREVINHITAnyLPlvvkkRLGLYCFIEPDvpvalngdpmRLQQVISNLLSNAIKFTDT 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 514 GGhITFSVDVNEEeeLLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGK 593
Cdd:PRK10841 581 GC-IVLHVRVDGD--YLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGM 657
|
....*....
gi 521289351 594 GTTITFTLP 602
Cdd:PRK10841 658 GSQFTIRIP 666
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
381-602 |
6.30e-25 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 109.83 E-value: 6.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 381 REFVANVSHELRTPLTTMRSYLEALAEGawQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRF 460
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQ--ALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 461 FSLIIERFEMTKEQHVeFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEELlyISVKDEGVG 540
Cdd:TIGR03785 564 LSGCMQGYQMTYPPQR-FELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHAL--LTVSNEGPP 640
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521289351 541 IPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQAHGGDIWADSI-EGKGTTITFTLP 602
Cdd:TIGR03785 641 LPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
481-601 |
1.17e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 93.73 E-value: 1.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 481 NLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVdvNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKAR 560
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTL--REDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSR 83
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 521289351 561 TRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTL 601
Cdd:cd16947 84 NSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-602 |
6.81e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 90.56 E-value: 6.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 493 PDKITQVLDNIISNALKYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRvdkarTRRLG-GTGLGL 571
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRIT--IRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 521289351 572 AIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16943 74 SLSYRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-602 |
7.11e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 90.81 E-value: 7.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 499 VLDNIISNALKYSPEGGHITFSVDVNEEEELLyiSVKDEGVGIPRKDMEKIFERFYRVDKARTRRlGGTGLGLAIAKEMV 578
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVL--SIKDFGIGIPEEDLPRVFDKGFTGENGRNFQ-ESTGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 521289351 579 QAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
372-608 |
1.06e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 100.10 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 372 EQEQIDQERREFVANVSHELRTPLTTMRSYLEALaegawQDPNIAP---RFLNVTQNETERMIRLVNDLLQLSKFDSKDY 448
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELL-----QNTPLTAeqmDLADTARQCTLSLLAIINNLLDFSRIESGQM 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 449 QFNKEWIHFIRFFS---LIIERFEMTKEQHVE-FISnlPDRELYVEIDPDKITQVLDNIISNALKYSPEGGhitFSVDVN 524
Cdd:PRK15347 465 TLSLEETALLPLLDqamLTIQGPAQSKSLTLRtFVG--AHVPLYLHLDSLRLRQILVNLLGNAVKFTETGG---IRLRVK 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 525 EEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKartrRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYK 604
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
....
gi 521289351 605 EEQE 608
Cdd:PRK15347 616 EYAP 619
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-598 |
1.16e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 90.54 E-value: 1.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 485 RELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVdvnEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKartRRL 564
Cdd:cd16940 3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL---SADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNY 76
|
90 100 110
....*....|....*....|....*....|....
gi 521289351 565 GGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTIT 598
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAW 110
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
382-604 |
1.98e-21 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 96.86 E-value: 1.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 382 EFVANVSHELRTPLTTMRSYLEALAEGAWQDPNiAPRFLNVTQNETERMIRLVNDLLQLSKFDSKdyqfNKEWIHFirff 461
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQLLQEPELSDEK-RKQYIRIALEELDRAEAIITDYLTFAKPQPE----KLEKIDV---- 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 462 SLIIERFEMT-----KEQHVEFISNLPDrELYVEIDPDKITQVLDNIISNALKYSPEGGhiTFSVDVNEEEELLYISVKD 536
Cdd:COG5806 274 SEELEHVIDVlspyaNMNNVEIQTELEP-GLYIEGDRQKLQQCLINIIKNGIEAMPNGG--TLTIDVSIDKNKVIISIKD 350
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521289351 537 EGVGIPRKDMEKIFERFYrvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYK 604
Cdd:COG5806 351 TGVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-602 |
4.98e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 88.26 E-value: 4.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 499 VLDNIISNALKYSpeggHITFSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMV 578
Cdd:cd16939 4 ALDNLLRNALRYA----HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....
gi 521289351 579 QAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-602 |
5.35e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 88.21 E-value: 5.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 499 VLDNIISNALKYSPEGGHItfSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKArtRRLGGTGLGLAIAKEMV 578
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRI--YITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 521289351 579 QAHGGDIWAdSIEGKGTTITFTLP 602
Cdd:cd16923 80 ELHGGSASA-EYDDNHDLFKVRLP 102
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
372-604 |
8.23e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 97.28 E-value: 8.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 372 EQEQIDQERREFVANVSHELRTPLTTMRSYLEALAegawqDPNIAPR---FLNVTQNETERMIRLVNDLLQLSKFD--SK 446
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLA-----DNPALNAqrdDLRAITDSGESLLTILNDILDYSAIEagGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 447 DYQFNKEWIHFIRFFSLIIERFE-MTKEQHVEFISNLPDR-ELYVEIDPDKITQVLDNIISNALKYSpEGGHITFSVDVN 524
Cdd:PRK11466 511 NVSVSDEPFEPRPLLESTLQLMSgRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTD 589
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 525 EEEelLYISVKDEGVGIPRKDMEKIFERFYRVdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYK 604
Cdd:PRK11466 590 GEQ--WLVEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
375-605 |
1.81e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 94.21 E-value: 1.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 375 QIDQERREFVANVSHELRTPLTTMR----------SYLealAEGAWQDpniaprflnvtqneTERMIRLVNDLLQLSKFD 444
Cdd:PRK09467 224 QLEDDRTLLMAGVSHDLRTPLTRIRlatemmseedGYL---AESINKD--------------IEECNAIIEQFIDYLRTG 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 445 SKDyQFNKEWIHfirffSLIIERFEMTKEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYspegGHITFSVDVN 524
Cdd:PRK09467 287 QEM-PMEMADLN-----ALLGEVIAAESGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARY----GNGWIKVSSG 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 525 EEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRlgGTGLGLAIAKEMVQAHGGDI-WADSIEGkGTTITFTLPY 603
Cdd:PRK09467 357 TEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG-GLSARAWLPL 433
|
..
gi 521289351 604 KE 605
Cdd:PRK09467 434 TT 435
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
382-602 |
3.40e-20 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 95.30 E-value: 3.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 382 EFVANVSHELRTPL----------------TTMRSYLealaegawqdpniaprflnvtqNETER----MIRLVNDLLQLS 441
Cdd:PRK11107 295 EFLANMSHELRTPLngvigftrqtlktpltPTQRDYL----------------------QTIERsannLLAIINDILDFS 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 442 KFDSkdyqfNK---EWIHF-IRffSLIIErfEMT------KEQHVEFI----SNLPDrelYVEIDPDKITQVLDNIISNA 507
Cdd:PRK11107 353 KLEA-----GKlvlENIPFsLR--ETLDE--VVTllahsaHEKGLELTlnidPDVPD---NVIGDPLRLQQIITNLVGNA 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 508 LKYSPEGghitfSVDVNEEEE-------LLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRLGGTGLGLAIAKEMVQA 580
Cdd:PRK11107 421 IKFTESG-----NIDILVELRalsntkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNE 495
|
250 260
....*....|....*....|..
gi 521289351 581 HGGDIWADSIEGKGTTITFTLP 602
Cdd:PRK11107 496 MGGDISFHSQPNRGSTFWFHLP 517
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-599 |
4.47e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 85.59 E-value: 4.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 492 DPDKITQVLDNIISNALKYSPEGGHItfSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRlGGTGLGL 571
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTV--SISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGL 77
|
90 100
....*....|....*....|....*...
gi 521289351 572 AIAKEMVQAHGGDIWADSIEGKGTTITF 599
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-602 |
1.58e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 83.99 E-value: 1.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALK----YSPEGGHITFSVDVNEEEELLyISVKDEGVGIPRKDMEKIFERFYrvdkarTRRLGGTGLGL 571
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVT-ISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 521289351 572 AIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16920 74 SICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
373-582 |
1.54e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 88.55 E-value: 1.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 373 QEQIDQERReFVANVSHELRTPLTTMRSYLEaLAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNK 452
Cdd:PRK10337 231 HAMMVRERR-FTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDV 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 453 EWIHFIRFF-SLIIERFEMTKEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVNEeeelly 531
Cdd:PRK10337 309 AEIPLEDLLqSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN------ 382
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 521289351 532 ISVKDEGVGIPRKDMEKIFERFYR---VDKArtrrlgGTGLGLAIAKEMVQAHG 582
Cdd:PRK10337 383 FTVRDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLHG 430
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-585 |
2.43e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 80.58 E-value: 2.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 492 DPDKITQVLDNIISNALKYSPEGGHITFSVDVNEEEelLYISVKDEGVGIPRKDMEKIFERFYRVDKARTRRlGGTGLGL 571
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEG--IELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGL 77
|
90
....*....|....
gi 521289351 572 AIAKEMVQAHGGDI 585
Cdd:cd16945 78 AFVQEVAQLHGGRI 91
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
383-608 |
7.67e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 87.81 E-value: 7.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 383 FVANVSHELRTPLTTMRSYLEaLAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLS-KFDSKDYQFN-KEWIHFIRf 460
Cdd:PRK13837 453 LASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAFGrKGERNTKPFDlSELVTEIA- 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 461 fSLIierfEMTKEQHVEFISNLPDRELYVEIDPDKITQVLDNIISNALKYSPEGGHITFSVDVNE-------------EE 527
Cdd:PRK13837 531 -PLL----RVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrapkvlshgvlpPG 605
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 528 ELLYISVKDEGVGIPRKDMEKIFERFYrvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQ 607
Cdd:PRK13837 606 RYVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKV 679
|
.
gi 521289351 608 E 608
Cdd:PRK13837 680 P 680
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-602 |
1.05e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 78.64 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALKYSpeGGHITFSVDVNEEeeLLYISVKDEGVGIPRKDMEKIFERFYRVDKARTrrLGGTGLGLAIAK 575
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGN--RTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQ 74
|
90 100
....*....|....*....|....*..
gi 521289351 576 EMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16950 75 RISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
377-442 |
1.07e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 77.25 E-value: 1.07e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521289351 377 DQERREFVANVSHELRTPLTTMRSYLEALAEGAWQDPNIApRFLNVTQNETERMIRLVNDLLQLSK 442
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
498-602 |
1.16e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 78.77 E-value: 1.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 498 QVLDNIISNALKYSP-EGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYrVDKARTRRLG-GTGLGLAIAK 575
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRIT--VSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 521289351 576 EMVQAHGGDIWADSIE----GKGTTITFTLP 602
Cdd:cd16953 80 QIIEAHGGISVAENHNqpgqVIGARFTVQLP 110
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
379-445 |
1.66e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 76.87 E-value: 1.66e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521289351 379 ERREFVANVSHELRTPLTTMRSYLEALAEgaWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDS 445
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
169-592 |
2.52e-17 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 85.51 E-value: 2.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 169 VVASMDNVYNQIRTINTILASGTFIALGITAFLGIF-VARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLAttf 247
Cdd:COG4192 310 LVALNQETAQLVQQSGILLLAIALLSLLLAVLINYFyVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIA--- 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 248 nyltrelkeaqsmtegerkklssviaymtdgviatnrngaiillntpalELLNVSRETAlempitsllgledeytfedlV 327
Cdd:COG4192 387 -------------------------------------------------RLLRVFRDQA--------------------I 397
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 328 EQQDSLLLEIEQEERtsvlrvnfsvIQKEhgkidgLIAviydvTEQEQIDQERREFVA----NVSHELRTPLTTMRSYL- 402
Cdd:COG4192 398 EKTQELETEIEERKR----------IEKN------LRQ-----TQDELIQAAKMAVVGqtmtSLAHELNQPLNAMSMYLf 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 403 EALAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFnkewihfIRFFSLIIERFEMTKEQH--VEFIS 480
Cdd:COG4192 457 SAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP-------VDLRQVIEQAWELVESRAkpQQITL 529
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 481 NLPDrELYVEIDPDKITQVLDNIISNALKYSPEGGHItfSVDVNEEEELLYISVKDEGVGIPrkDMEKIFERFYrvdkar 560
Cdd:COG4192 530 HIPD-DLMVQGDQVLLEQVLVNLLVNALDAVATQPQI--SVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------ 598
|
410 420 430
....*....|....*....|....*....|...
gi 521289351 561 TRRLGGTGLGLAIAKEMVQAHGGDIW-ADSIEG 592
Cdd:COG4192 599 TTKEVGLGLGLSICRSIMQQFGGDLYlASTLER 631
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
379-445 |
1.25e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 74.52 E-value: 1.25e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521289351 379 ERREFVANVSHELRTPLTTMRSYLEALAEGAWQDPNiaPRFLNVTQNETERMIRLVNDLLQLSKFDS 445
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
260-604 |
1.66e-15 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 78.20 E-value: 1.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 260 MTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLG---LEDEYTFEDLVEQQ---DS- 332
Cdd:PRK11073 1 MATGTLPDAGQILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSyfsLNIELMRESLQAGQgftDNe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 333 LLLEIEqeERTSVLRVNFSVIQkehgkiDGLIAViydvtEQEQIDQERR---------------EFVANVSHELRTPLTT 397
Cdd:PRK11073 81 VTLVID--GRSHILSLTAQRLP------EGMILL-----EMAPMDNQRRlsqeqlqhaqqvaarDLVRGLAHEIKNPLGG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 398 MRSYLEALAEgAWQDPNIApRFLNVTQNETERMIRLVNDLLQLSKFDSKdyqfNKEWIHFI--RFFSLIierfEMTKEQH 475
Cdd:PRK11073 148 LRGAAQLLSK-ALPDPALT-EYTKVIIEQADRLRNLVDRLLGPQRPGTH----VTESIHKVaeRVVQLV----SLELPDN 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 476 VEFISN----LPDrelyVEIDPDKITQVLDNIISNALK-YSPEGGHIT------FSVDVNEEEELLY--ISVKDEGVGIP 542
Cdd:PRK11073 218 VRLIRDydpsLPE----LAHDPDQIEQVLLNIVRNALQaLGPEGGTITlrtrtaFQLTLHGERYRLAarIDIEDNGPGIP 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521289351 543 RKDMEKIFerfYRVDKARTrrlGGTGLGLAIAKEMVQAHGGDIWADSIEGKgTTITFTLPYK 604
Cdd:PRK11073 294 PHLQDTLF---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
473-585 |
1.14e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 71.12 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 473 EQHVEFISNLPDrELYVEIDPDKITQVLDNIISNALKYSPEggHITFSVDVNEEEelLYISVKDEGVGIPRKDMEKIFER 552
Cdd:cd16954 16 RKGVSISLDISP-ELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGG--LHLIVDDDGPGVPESQRSKIFQR 90
|
90 100 110
....*....|....*....|....*....|...
gi 521289351 553 FYRVDKARTrrlgGTGLGLAIAKEMVQAHGGDI 585
Cdd:cd16954 91 GQRLDEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
154-609 |
7.26e-14 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 74.56 E-value: 7.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 154 TPIKKSNQETIGAIYVVASMDNVYNQIRTINTILasgtFIALGITAFLGI----FVARTITHPLSDMRKQAIelakgnfs 229
Cdd:PRK11086 149 TPVYDENGKQIGVVAVGISLSEVTEQINESRWSI----YWSILFGALVGLigtvILVRVLKRILFGLEPYEI-------- 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 230 rkvrkygndeigqlATTFnyltrelKEAQSMtegerkkLSSVIaymtDGVIATNRNGAIILLNTPALELLNVSR---ETA 306
Cdd:PRK11086 217 --------------STLF-------EQRQAM-------LQSIK----EGVIAVDDRGEVTLINDEAKRLFNYKKgleDDP 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 307 LEMPITSLLGLEDeytFEDLVEQQDSLLLEiEQEERTSVLRVNfSVIQKEHGKIDGLIAVIYDVTEQEQIDQErrefvan 386
Cdd:PRK11086 265 LGTDVESWMPVSR---LKEVLRTGTPRRDE-EININGRLLLTN-TVPVRVNGEIIGAIATFRDKTEVRQLAQR------- 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 387 vshelrtpLTTMRSYLEALAEGAWQdpniaprFLNvtqneterMIRLVNDLLQLSKFDS-KDY------QFNKEWIHFIR 459
Cdd:PRK11086 333 --------LDGMVNYADALRAQSHE-------FMN--------KLHVILGLLHLKSYDQlEDYilktanNYQEEIGSLLG 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 460 ------FFSLIIERFEMTKEQHVEFI----SNLPDRElyveiDPDKITQ---VLDNIISNALKY--SPEGGHITFSVDVN 524
Cdd:PRK11086 390 kikspvIAGFLLGKISRARELGITLIisedSQLPDSG-----DEDQVHElitILGNLIENALEAvgGEEGGEISVSLHYR 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 525 EEEelLYISVKDEGVGIPRKDMEKIFERFYRVdKARTRrlggtGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYK 604
Cdd:PRK11086 465 NGW--LHCEVSDDGPGIAPDEIDAIFDKGYST-KGSNR-----GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWD 536
|
....*
gi 521289351 605 EEQED 609
Cdd:PRK11086 537 GERSN 541
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-602 |
2.82e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 63.33 E-value: 2.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 492 DPDKITQVLDNIISNALKySPEG-----GHITFSVDVNEEEELLyISVKDEGVGIPRKDMEKIFERFYrvdkarTRRLGG 566
Cdd:cd16944 1 DTTQISQVLTNILKNAAE-AIEGrpsdvGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEPYV------TTRPKG 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 521289351 567 TGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
167-606 |
3.24e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 68.89 E-value: 3.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 167 IYVVASMDNVYNQIRTINTILASGTFIALGITAFLGIFVARTITHPLSDMRKQAIELAKGNFSRkVRKYGNDEIGQLATT 246
Cdd:COG2972 139 LVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARS 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 247 FNYLTRELKEaqsmtegerkklssviaymtdgviatnrngaiillntpalellnvsretalempitsllgledeytfedL 326
Cdd:COG2972 218 FNEMVERIKE---------------------------------------------------------------------L 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 327 VEQQdsllLEIEQEERTSVLRVNfsviqkehgkidgliaviydvteQEQIdqeRREFVANVshelrtpLTTMRSYleALA 406
Cdd:COG2972 229 IEEV----YELELEKKEAELKAL-----------------------QAQI---NPHFLFNT-------LNSIRWL--AEL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 407 EGAwqdpniaprflnvtqNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIR-FFSLIIERFEmtkeQHVEFISNLPDR 485
Cdd:COG2972 270 EDP---------------EEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKsYLEIQKLRFG----DRLEVEIEIDEE 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 486 ELYVEIdPDKITQVL-DNIISNALKYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKartrrl 564
Cdd:COG2972 331 LLDLLI-PKLILQPLvENAIEHGIEPKEGGGTIR--ISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGE------ 401
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 521289351 565 gGTGLGLAIAKEMVQAHGGD---IWADSIEGKGTTITFTLPYKEE 606
Cdd:COG2972 402 -GRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
498-602 |
5.92e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 62.78 E-value: 5.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 498 QVLDNIISNALKYSPEGGHITFS---VDVNEEEELLY----------ISVKDEGVGIPRKDMEKIFERFYRvdkarTRRL 564
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIEtsnQRVDADYALNYrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 521289351 565 G-GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-602 |
1.09e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 61.65 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALK-YSPEGGHITFSVDVNEEEEL--------LYISVKDEGVGIPRKDMEKIFERFYrvdkarTRRLGG 566
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRTRTQRQVTLghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 521289351 567 TGLGLAIAKEMVQAHGGDIWADSIEGKgTTITFTLP 602
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-601 |
4.59e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.78 E-value: 4.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 496 ITQVLDNIISNALKYSPEGGHITFSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRvdkarTRRLG-GTGLGLAIA 574
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 521289351 575 KEMVQAHGGDIWADSIEGKGTTITFTL 601
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HAMP |
pfam00672 |
HAMP domain; |
204-256 |
1.22e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 56.86 E-value: 1.22e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 521289351 204 FVARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATTFNYLTRELKE 256
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
210-254 |
1.27e-10 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 56.68 E-value: 1.27e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 521289351 210 THPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATTFNYLTREL 254
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-602 |
2.06e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 58.07 E-value: 2.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 499 VLDNIISNALKYSPE--GGHITFSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRvdkarTRRLGGTGLGLAIAKE 576
Cdd:cd16915 4 IVGNLIDNALDALAAtgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 521289351 577 MVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
498-585 |
2.54e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 63.11 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 498 QVLDNIISNALKYSPEGGHITfsvdVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKARTrrlgGTGLGLAIAKEM 577
Cdd:PRK10815 381 EVMGNVLDNACKYCLEFVEIS----ARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREI 452
|
....*...
gi 521289351 578 VQAHGGDI 585
Cdd:PRK10815 453 TEQYEGKI 460
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
186-392 |
2.64e-10 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 62.98 E-value: 2.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 186 ILASGTFIALGITAFLGIFVARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATTFNYLTRELKEAQSMTEGER 265
Cdd:COG3850 119 LALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEE 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 266 KKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSLLLEIEQEERTSV 345
Cdd:COG3850 199 ELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASAL 278
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 521289351 346 LRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERREFVANVSHELR 392
Cdd:COG3850 279 LLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIAN 325
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
15-256 |
9.41e-10 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 61.19 E-value: 9.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 15 TLIYVLLIIVAMQIIGVYFVNEMEKSLLKSYNDSLDQRVNNLSYYLEQEMTKDRSTSSSTTLKEDAERILNDFSKEGEIL 94
Cdd:COG0840 10 LLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 95 EVSLIDKSYEVIATSNPYNREVAG--KKTTEGIIKRTLLVGIPYENKFFDPERDSKVRISVTPIKKSNQETIGAIYVVAS 172
Cdd:COG0840 90 LLLLALLALALAALALLAALAALLalLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 173 MDNVYNQIRTINTILASGTFIALGITAFLGIFVARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATTFNYLTR 252
Cdd:COG0840 170 AALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIE 249
|
....
gi 521289351 253 ELKE 256
Cdd:COG0840 250 NLRE 253
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
207-259 |
9.56e-10 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 54.56 E-value: 9.56e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 521289351 207 RTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATTFNYLTRELKEAQS 259
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
372-606 |
9.76e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 59.63 E-value: 9.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 372 EQEQIDQERREFVA----NVSHELrtplTTMRSYLEALAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLL------QLS 441
Cdd:COG4585 46 AEEAREEERRRIARelhdGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVrglrppALD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 442 KFDskdyqfnkewihFIRFFSLIIERFEMTKEQHVEFISNLPDRELyveiDPDKITQVLDNI---ISNALKYSPeGGHIT 518
Cdd:COG4585 122 DLG------------LAAALEELAERLLRAAGIRVELDVDGDPDRL----PPEVELALYRIVqeaLTNALKHAG-ATRVT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 519 fsVDVNEEEELLYISVKDEGVGIPrkdmekiferfyrvdkarTRRLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTIT 598
Cdd:COG4585 185 --VTLEVDDGELTLTVRDDGVGFD------------------PEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVR 244
|
....*...
gi 521289351 599 FTLPYKEE 606
Cdd:COG4585 245 ATLPLAAA 252
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
490-610 |
1.61e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 60.45 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 490 EIDPDKITQVLDNIISNALKYSPEGGHITFS---VDVNEEEELLY----------ISVKDEGVGIPRKDMEKIFERFYRv 556
Cdd:PRK13557 272 RIDPTQAEVALLNVLINARDAMPEGGRVTIRtrnVEIEDEDLAMYhglppgryvsIAVTDTGSGMPPEILARVMDPFFT- 350
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 521289351 557 dkarTRRLG-GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDD 610
Cdd:PRK13557 351 ----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAENP 401
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
504-602 |
1.68e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 54.87 E-value: 1.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 504 ISNALKYSPeGGHITFSVDVNEEEELLYisVKDEGVGIPRKDMEkiferfyrvdkartrrlGGTGLGLAIAKEMVQAHGG 583
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLT--VVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELLGG 68
|
90
....*....|....*....
gi 521289351 584 DIWADSIEGKGTTITFTLP 602
Cdd:cd16917 69 TLTIGSRPGGGTRVTARLP 87
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-486 |
1.83e-09 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 60.51 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 1 MNKVSFFRSIHFKFTLIYVLLIIVAMQIIGVYFVNEMEKSLLKSYNDSLDQRVNNLSYYLEQEMTKDRSTSSSTTLKEDA 80
Cdd:COG2770 31 ISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 81 ERILNDFSKEGEILEVSLIDKSYEVIATSNPYNREVAGKKTTEGIIKRTLLVGIPYENKFFDPERDSKVRISVTPIKKSN 160
Cdd:COG2770 111 LLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAAL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 161 QETIGAIYVVASMDNVYNQIRTINTILAsgtFIALGITAFLGIFVARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEI 240
Cdd:COG2770 191 LLLLLGGLLLVVLLEAALAALLLLLLLA---LLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 241 GQLATTFNYLTRELKEAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDE 320
Cdd:COG2770 268 GELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLA 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 321 YTFEDLVEQQDSLLLEIEQEERTSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERREFVANVSHELRTPLTTMRS 400
Cdd:COG2770 348 ADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAA 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 401 YLEALAEGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEWIHFIRFFSLIIERFEMTKEQHVEFIS 480
Cdd:COG2770 428 AAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAE 507
|
....*.
gi 521289351 481 NLPDRE 486
Cdd:COG2770 508 ELLLLE 513
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
265-382 |
3.43e-08 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 56.32 E-value: 3.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 265 RKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLgleDEYTFEDLVEQQDSLLLEIEQEERTS 344
Cdd:COG3829 10 EEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVIQKTGGKG 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 521289351 345 VLRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERRE 382
Cdd:COG3829 87 KTVIVTAIPIFEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
256-382 |
4.39e-08 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 54.65 E-value: 4.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 256 EAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSLLL 335
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 521289351 336 EIEQEER-------TSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERRE 382
Cdd:COG2202 81 VWRGELRnrrkdgsLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
167-608 |
5.23e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 52.60 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 167 IYVVASMDNVYNQIRTINTILASGTFIALGITAFLGIFVARTITHPLSDMRKQAIELAKGNFSRKVRKYGNDEIGQLATT 246
Cdd:COG3920 70 ALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAEL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 247 FNYLTRELKEAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDL 326
Cdd:COG3920 150 AVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAA 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 327 VEQQDSLLLEIEQEERT-----SVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEQIDQERREFVAN-------VSHELRTP 394
Cdd:COG3920 230 LLRLRAAVLEELERRRRarglgRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEkelllreLHHRVKNN 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 395 LTTMRSYLEALAEGAwQDPNIApRFLNVTQNeteRM--IRLVNDLLqlskFDSKDYQFnkewIHFIRFFSLIIERF-EMT 471
Cdd:COG3920 310 LQVVSSLLRLQARRA-DDPEAR-EALEESQN---RIqaLALVHELL----YQSEDWEG----VDLRDYLRELLEPLrDSY 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 472 KEQHVEFISNLPDrelyVEIDPDKITQ---VLDNIISNALKY---SPEGGHITfsVDVNEEEELLYISVKDEGVGIPRkd 545
Cdd:COG3920 377 GGRGIRIELDGPD----VELPADAAVPlglILNELVTNALKHaflSGEGGRIR--VSWRREDGRLRLTVSDNGVGLPE-- 448
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521289351 546 mekiferfyRVDKARTRrlggtGLGLAIAKEMVQAHGGDIwaDSIEGKGTTITFTLPYKEEQE 608
Cdd:COG3920 449 ---------DVDPPARK-----GLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAELAA 495
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
275-370 |
7.46e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 48.01 E-value: 7.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 275 MTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSLLLEIEQEER-------TSVLR 347
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRlrrkdgsVIWVL 80
|
90 100
....*....|....*....|...
gi 521289351 348 VNFSVIQKEHGKIDGLIAVIYDV 370
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
482-601 |
2.22e-06 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 47.45 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 482 LPDrelYVEIDPDKITQVLDNIISNALKYSPEGGHITFSV-------DVNEEEELLYISVKDEG-------VGIPRKDME 547
Cdd:cd16938 1 LPD---VVVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVfleggseDRSDRDWGPWRPSMSDEsveirfeVEINDSGSP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 521289351 548 KIFERFYRvdKARTRRLG----GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTL 601
Cdd:cd16938 78 SIESASMR--NSLNRRYNlselGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
267-330 |
5.60e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 44.31 E-value: 5.60e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521289351 267 KLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQ 330
Cdd:smart00091 2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRL 65
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
494-602 |
1.45e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.90 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 494 DKITQVLDNIISNALKYS---PEGGHITFSVDVNEEEelLYISVKDEGVGIPRKDMEkiferfyrvDKARTRRLGgtGLG 570
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDG--LEIEVRDEGPGFDPEDLP---------DPYSTLAEG--GRG 99
|
90 100 110
....*....|....*....|....*....|....*.
gi 521289351 571 LAIAKEMvqahggdiwADSIE----GKGTTITFTLP 602
Cdd:COG2172 100 LFLIRRL---------MDEVEyesdPGGTTVRLVKR 126
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
277-610 |
1.90e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 47.52 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 277 DGVIATNRNGAIILLNTPALELLNVSRetalemPITSLLGledeYTFEDLVEQQDSLLLEIEQEERTSVLRVN-FSVIQK 355
Cdd:PRK15053 233 EGLIAVDPHGYITAINRNARKMLGLSS------PGRQWLG----KPIAEVVRPADFFTEQIDEKRQDVVANFNgLSVIAN 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 356 EHG--KIDGLIAVIYDVTEQEQIdqerrefvanvsHELRTPLTTMRSYLEALaegawqdpniaprflNVTQNETERMIRL 433
Cdd:PRK15053 303 REAirSGDDLLGAIISFRSKDEI------------STLNAQLTQIKQYVESL---------------RTLRHEHLNWMST 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 434 VNDLLQLSKFD------SKDYQFNKEWIHFIR-------FFSLIIERFEMTKEQ--HVEFISNLPDRELYVEIDPDKITQ 498
Cdd:PRK15053 356 LNGLLQMKEYDrvlemvQGESQAQQQLIDSLReafadrqVAGLLFGKVQRARELglKMVIVPGSQLSQLPPGLDSTEFAA 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 499 VLDNIISNALKYS---PEGGHITfSVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYrvdKARTRRLGGTGLGLAIAK 575
Cdd:PRK15053 436 IVGNLLDNAFEASlrsDEGNKIV-ELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEHGIGLYLIA 511
|
330 340 350
....*....|....*....|....*....|....*
gi 521289351 576 EMVQAHGGDIWADSIEGKGTTITFTLPyKEEQEDD 610
Cdd:PRK15053 512 SYVTRCGGVITLEDNDPCGTLFSIFIP-KVKPNDS 545
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
34-246 |
2.20e-05 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 46.18 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 34 VNEMEKSLLKSYNDSLDQRVNNLSYYLEQ-EMTKDRSTSSSTTLKEDAERILNDFSKEGEILEVSLIDKSYEVIATSNPY 112
Cdd:pfam02743 7 AEEQLLSLAKQLAENIESYLDSLEEILELlASNPDLQDLLSAPAEEELAKLESLLRSNPGISSIYLVDADGRVLASSDES 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 113 NREVAGKKTTEGIIKRTLLVGIPYENKFFDPERDS---KVRISVT-PIKKSNQETIGAIYVVASMDNVYNQIRTINtila 188
Cdd:pfam02743 87 PSYPGLDVSERPWYKEALKGGGGIIWVFSSPYPSSesgEPVLTIArPIYDDDGEVIGVLVADLDLDTLQELLSQIK---- 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521289351 189 sgtfIALGITAFL----GIFVARTITHPLSDMRKQ----AIELAKGNFSRKVRKYGNDEIGQLATT 246
Cdd:pfam02743 163 ----LGEGGYVFIvdsdGRILAHPLGKNLRSLLAPflgkSLADALPGSGITEIAVDLDGEDYLVAY 224
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
253-380 |
2.64e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 46.17 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 253 ELKEAQSMTEGERKKLSSVIAYMTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDS 332
Cdd:COG2202 124 ERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLE 203
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 521289351 333 LLLEIEQEE------RTSVLRVNFSVIQKEHG-KIDGLIAVIYDVTEQEQIDQER 380
Cdd:COG2202 204 GGRESYELElrlkdgDGRWVWVEASAVPLRDGgEVIGVLGIVRDITERKRAEEAL 258
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
378-613 |
2.71e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 47.23 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 378 QERREFVANVSHELRTPLTTMRSYLEALaeGAWQDPNIAPRFLNVTQNETERMIRLVNDLLQLSKFDSKDYQFNKEwihf 457
Cdd:PRK10618 448 QARKAFLQNIGDELKQPLQSLAQLAAQL--RQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQE---- 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 458 irFFSL-------IIERFEMTKEQHVE-FISNLPD-RELYVEidpDKItqVLDNIISNALKYS---PEGGHITFSVDV-N 524
Cdd:PRK10618 522 --LFSLqdlidevLPEVLPAIKRKGLQlLIHNHLKaEQLRIG---DRD--ALRKILLLLLNYAittTAYGKITLEVDQdE 594
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 525 EEEELLYISVKDEGVGIPRKDMEKIfeRFYRVDKARTRRLG-GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPY 603
Cdd:PRK10618 595 SSPDRLTIRILDTGAGVSIKELDNL--HFPFLNQTQGDRYGkASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM 672
|
250
....*....|
gi 521289351 604 KEEQEDDWDE 613
Cdd:PRK10618 673 LAADPEVEEE 682
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
498-602 |
9.10e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 42.03 E-value: 9.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 498 QVL-DNIISNALKYSPEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKIFERFYRVDKartrrlgGTGLGLA-IAK 575
Cdd:cd16957 7 QVLvENAIRHAFPKRKENNEVR--VVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-------GTGTALEnLNR 77
|
90 100
....*....|....*....|....*....
gi 521289351 576 EMVQAHG--GDIWADSIEGKGTTITFTLP 602
Cdd:cd16957 78 RLIGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
521-602 |
1.64e-04 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 42.71 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 521 VDVNEEEELLYISVKDEGVGIPRKDMEKIFERFY-----------RVDKARTRR--LGGTGLGLAIAKEMVQAHGGDIWA 587
Cdd:cd16929 75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddfSDLISGTQPspLAGFGYGLPMSRLYAEYFGGDLDL 154
|
90
....*....|....*
gi 521289351 588 DSIEGKGTTITFTLP 602
Cdd:cd16929 155 QSMEGYGTDVYIYLK 169
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
504-602 |
2.43e-04 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 43.84 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 504 ISNALKYSpEGGHItfSVDVNEEEELLYISVKDEGVGIPrkdmekiferfyrvdkARTRRlggTGLGLAIAKEMVQAHGG 583
Cdd:COG3851 409 LTNILKHA-EASQI--RISLSQDKRLLSLEIRDDGIGLP----------------PELRA---KGFGLRGMRERVRALGG 466
|
90
....*....|....*....
gi 521289351 584 DiWADSIEGKGTTITFTLP 602
Cdd:COG3851 467 D-FRLSSAPKGTRLSVLLP 484
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
275-370 |
3.50e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 40.48 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 275 MTDGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEYTFEDLVEQQDSLLLEIEQEERTSV--------L 346
Cdd:pfam00989 10 LPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFEVSFRvpdgrprhV 89
|
90 100
....*....|....*....|....
gi 521289351 347 RVNFSVIQKEHGKIDGLIAVIYDV 370
Cdd:pfam00989 90 EVRASPVRDAGGEILGFLGVLRDI 113
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
508-602 |
1.12e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 42.09 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 508 LKYSPEGGHItfsvdvneeeellYISVKDEGVGIprkDMEKIFErfyrvdKARTRRL---------------------G- 565
Cdd:COG0643 313 LSAYHEGGRV-------------VIEVSDDGRGL---DLEKIRA------KAIEKGLitaeeaaalsdeellelifapGf 370
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 521289351 566 ----------GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:COG0643 371 staeevtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
277-375 |
3.04e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 37.78 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 277 DGVIATNRNGAIILLNTPALELLNVSRETALEMPITSLLGLEDEytfeDLVEQQDSLLLE----IEQEERTS------VL 346
Cdd:pfam08448 6 DALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDA----ARLERALRRALEgeepIDFLEELLlngeerHY 81
|
90 100
....*....|....*....|....*....
gi 521289351 347 RVNFSVIQKEHGKIDGLIAVIYDVTEQEQ 375
Cdd:pfam08448 82 ELRLTPLRDPDGEVIGVLVISRDITERRR 110
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
512-602 |
4.17e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 38.72 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 512 PEGGHITFSVDvNEEEELLyISVKDEGVGI-PRKDMEKIFERFYRVDKARTR----------------------RLGGTG 568
Cdd:cd16916 67 PPEGTITLRAE-HQGNQVV-IEVSDDGRGIdREKIREKAIERGLITADEAATlsddevlnlifapgfstaeqvtDVSGRG 144
|
90 100 110
....*....|....*....|....*....|....
gi 521289351 569 LGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLP 602
Cdd:cd16916 145 VGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
504-602 |
9.36e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 38.81 E-value: 9.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521289351 504 ISNALKYSpEGGHITfsVDVNEEEELLYISVKDEGVGIPRKDMEKiferfyrvdkartrrlggtGLGLAIAKEMVQAHGG 583
Cdd:PRK11644 419 LNNIVKHA-DASAVT--LQGWQQDERLMLVIEDDGSGLPPGSGQQ-------------------GFGLRGMRERVTALGG 476
|
90
....*....|....*....
gi 521289351 584 DIWADSIEgkGTTITFTLP 602
Cdd:PRK11644 477 TLTISCTH--GTRLSVSLP 493
|
|
| |
