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Conserved domains on  [gi|521986893|ref|WP_020498164|]
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sialidase family protein [Sciscionella marina]

Protein Classification

sialidase family protein( domain architecture ID 10202570)

sialidase (glycoside hydrolase 33) family protein similar to sialidase (also known as neuraminidase) that removes sialic acid residues from glycoconjugates

CATH:  2.120.10.10
CAZY:  GH33
EC:  3.2.1.-
Gene Ontology:  GO:0004308|GO:0005975
PubMed:  7934919|8994884|7624375|8535779|21639842|31731209|20552664
SCOP:  4002683

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 218-476 7.77e-17

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


:

Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 81.73  E-value: 7.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 218 HTDDSAGAGNRYV-YSDDGGRSWTTDR---SGNPMPSV----PSVNLTKLSGGTLL---ATNYHTYLRTGSSTEASVETS 286
Cdd:cd15482   37 GAGDLGGDIDIVVrRSTDGGKTWSEPVtvvDGGGSGGAsygdPSLVVDPDTGRIFLfytSGPGGGGEALTGDGTVRVRLS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 287 VSTDGGASWTrrtgvlhtpqAMRPISTETDRPGTRLGGFVLVHGALEQpDGTLLQSAYGYYANDRTYRQLLLASTDGGRD 366
Cdd:cd15482  117 TSDDDGKTWS----------EPRDLTPQVKPSGWKFFFTGPGRGIQLS-DGRLVFPAYARNGGGGGDGAVVIYSDDGGKT 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 367 WTVRSTVAaqGGGQGYAEGAFAHTADGALLAVMRTGDYRPMVA-ARSTDDGRTWDPPQVLRSGSGelPVTSIyPVLEPLP 445
Cdd:cd15482  186 WTRGGGVP--SSGAGGDEPSIVELSDGRLLMNARNSGGGGGRAvAESTDGGETWSEPVPTPSLPD--PGCQG-SLIRLPD 260

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 521986893 446 GGRLALL--------TGRPGLRLYTSRD-GIRWSAPVSVD 476
Cdd:cd15482  261 GGRKVLLfsnpaspgKGRTNLTLRLSDDgGKTWPDVRVLE 300
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 218-476 7.77e-17

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 81.73  E-value: 7.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 218 HTDDSAGAGNRYV-YSDDGGRSWTTDR---SGNPMPSV----PSVNLTKLSGGTLL---ATNYHTYLRTGSSTEASVETS 286
Cdd:cd15482   37 GAGDLGGDIDIVVrRSTDGGKTWSEPVtvvDGGGSGGAsygdPSLVVDPDTGRIFLfytSGPGGGGEALTGDGTVRVRLS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 287 VSTDGGASWTrrtgvlhtpqAMRPISTETDRPGTRLGGFVLVHGALEQpDGTLLQSAYGYYANDRTYRQLLLASTDGGRD 366
Cdd:cd15482  117 TSDDDGKTWS----------EPRDLTPQVKPSGWKFFFTGPGRGIQLS-DGRLVFPAYARNGGGGGDGAVVIYSDDGGKT 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 367 WTVRSTVAaqGGGQGYAEGAFAHTADGALLAVMRTGDYRPMVA-ARSTDDGRTWDPPQVLRSGSGelPVTSIyPVLEPLP 445
Cdd:cd15482  186 WTRGGGVP--SSGAGGDEPSIVELSDGRLLMNARNSGGGGGRAvAESTDGGETWSEPVPTPSLPD--PGCQG-SLIRLPD 260

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 521986893 446 GGRLALL--------TGRPGLRLYTSRD-GIRWSAPVSVD 476
Cdd:cd15482  261 GGRKVLLfsnpaspgKGRTNLTLRLSDDgGKTWPDVRVLE 300
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 282-504 3.46e-08

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 55.02  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893  282 SVETSVSTDGGASWTRRTGVLHTPQamrpisteTDRPGTRLGGFVLVHgaleQPDGTLL-----QSAYGYYANDRTYRQL 356
Cdd:pfam13088  19 SIWRSVFDPGSNKWSAPQVVADGEQ--------LGRYIRKLGNPVLFR----DPGGTLVlfykvGVSPGGWAGSKIYRIT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893  357 llaSTDGGRDWTVRSTVAAQGGGQ--GYAEGAFAHTADGALLAVMRTGDYRPMVAA--RSTDDGRTWDPPQVLRSGSGEl 432
Cdd:pfam13088  87 ---SSDNGRTWSAPRRLPPGPFLNisGPVKNKPVQLADGRLLLPSYHELAGKWAAHleLSDDGGVTWRKGRPDNAISGE- 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521986893  433 pvtsIYPVLEPLPGGRLALL---TGRPGLRLYTSRDGIRWSAPVSVDYRNSGNGT---MVRTGNSLLVFGDRGANWAR 504
Cdd:pfam13088 163 ----LQPSVLVLADGRLVMLfrsQEGAILASESTDGGLTWSPPEPTNLPNPNSGIdavNLPDGRLLLVYNPPNAGKPR 236
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
 231-490 3.79e-08

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 55.33  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 231 YSDDGGRSWTTDRS--------------GNPMPSVPSVNltklsgGT--LLATNYHTYLRTGSSTE---------ASVET 285
Cdd:COG4409   74 RSTDGGKTWSPPQVildygeggglsagvGDPAPVVDRKT------GRifLLADWMPGNDGEGWSGSepgtdpkgtRQLWV 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 286 SVSTDGGASWTrrtgvlhTPqamRPISTETDRPGTRL------GGFVLVHGALEqpdGTLLQSAYgyYANDRTYRQLLLA 359
Cdd:COG4409  148 TYSDDDGKTWS-------EP---RNITPQVKDPDWRFlatgpgHGIQLKNGEHK---GRLVFPAY--YSDGGKPSAAVIY 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 360 STDGGRDWTVRSTVAAQGGGQgyaEGAFAHTADGALLAVMRTGDYRPMVA-ARSTDDGRTWDPPQVlrsgSGEL--PVT- 435
Cdd:COG4409  213 SDDHGKTWKLGESANDKANTN---EAQVVELSDGRLMLNMRNQSGGGKRAvATSKDGGETWSEVTF----DPALpePVCq 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521986893 436 -SIYPVLEPLPGGRLAL-----LTGRPGLRLYTSRD-GIRWSAPVSVDYRNSGNGTMVRTGN 490
Cdd:COG4409  286 aSIIRYDKGDGKDVLLFsnpasPKGRKNGTVRLSYDdGKTWPYSKVIEPGGSAYSCLTVLDD 347
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 218-476 7.77e-17

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 81.73  E-value: 7.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 218 HTDDSAGAGNRYV-YSDDGGRSWTTDR---SGNPMPSV----PSVNLTKLSGGTLL---ATNYHTYLRTGSSTEASVETS 286
Cdd:cd15482   37 GAGDLGGDIDIVVrRSTDGGKTWSEPVtvvDGGGSGGAsygdPSLVVDPDTGRIFLfytSGPGGGGEALTGDGTVRVRLS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 287 VSTDGGASWTrrtgvlhtpqAMRPISTETDRPGTRLGGFVLVHGALEQpDGTLLQSAYGYYANDRTYRQLLLASTDGGRD 366
Cdd:cd15482  117 TSDDDGKTWS----------EPRDLTPQVKPSGWKFFFTGPGRGIQLS-DGRLVFPAYARNGGGGGDGAVVIYSDDGGKT 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 367 WTVRSTVAaqGGGQGYAEGAFAHTADGALLAVMRTGDYRPMVA-ARSTDDGRTWDPPQVLRSGSGelPVTSIyPVLEPLP 445
Cdd:cd15482  186 WTRGGGVP--SSGAGGDEPSIVELSDGRLLMNARNSGGGGGRAvAESTDGGETWSEPVPTPSLPD--PGCQG-SLIRLPD 260

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 521986893 446 GGRLALL--------TGRPGLRLYTSRD-GIRWSAPVSVD 476
Cdd:cd15482  261 GGRKVLLfsnpaspgKGRTNLTLRLSDDgGKTWPDVRVLE 300
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 282-504 3.46e-08

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 55.02  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893  282 SVETSVSTDGGASWTRRTGVLHTPQamrpisteTDRPGTRLGGFVLVHgaleQPDGTLL-----QSAYGYYANDRTYRQL 356
Cdd:pfam13088  19 SIWRSVFDPGSNKWSAPQVVADGEQ--------LGRYIRKLGNPVLFR----DPGGTLVlfykvGVSPGGWAGSKIYRIT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893  357 llaSTDGGRDWTVRSTVAAQGGGQ--GYAEGAFAHTADGALLAVMRTGDYRPMVAA--RSTDDGRTWDPPQVLRSGSGEl 432
Cdd:pfam13088  87 ---SSDNGRTWSAPRRLPPGPFLNisGPVKNKPVQLADGRLLLPSYHELAGKWAAHleLSDDGGVTWRKGRPDNAISGE- 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521986893  433 pvtsIYPVLEPLPGGRLALL---TGRPGLRLYTSRDGIRWSAPVSVDYRNSGNGT---MVRTGNSLLVFGDRGANWAR 504
Cdd:pfam13088 163 ----LQPSVLVLADGRLVMLfrsQEGAILASESTDGGLTWSPPEPTNLPNPNSGIdavNLPDGRLLLVYNPPNAGKPR 236
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
 231-490 3.79e-08

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 55.33  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 231 YSDDGGRSWTTDRS--------------GNPMPSVPSVNltklsgGT--LLATNYHTYLRTGSSTE---------ASVET 285
Cdd:COG4409   74 RSTDGGKTWSPPQVildygeggglsagvGDPAPVVDRKT------GRifLLADWMPGNDGEGWSGSepgtdpkgtRQLWV 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 286 SVSTDGGASWTrrtgvlhTPqamRPISTETDRPGTRL------GGFVLVHGALEqpdGTLLQSAYgyYANDRTYRQLLLA 359
Cdd:COG4409  148 TYSDDDGKTWS-------EP---RNITPQVKDPDWRFlatgpgHGIQLKNGEHK---GRLVFPAY--YSDGGKPSAAVIY 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 360 STDGGRDWTVRSTVAAQGGGQgyaEGAFAHTADGALLAVMRTGDYRPMVA-ARSTDDGRTWDPPQVlrsgSGEL--PVT- 435
Cdd:COG4409  213 SDDHGKTWKLGESANDKANTN---EAQVVELSDGRLMLNMRNQSGGGKRAvATSKDGGETWSEVTF----DPALpePVCq 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521986893 436 -SIYPVLEPLPGGRLAL-----LTGRPGLRLYTSRD-GIRWSAPVSVDYRNSGNGTMVRTGN 490
Cdd:COG4409  286 aSIIRYDKGDGKDVLLFsnpasPKGRKNGTVRLSYDdGKTWPYSKVIEPGGSAYSCLTVLDD 347
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 223-430 1.18e-07

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 53.10  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893  223 AGAGNRYVYSDDGGRSWTTDRSGNPMPSVPSVNLTK-----LSGGTLLATNYHTylrTGSSTEASVETSvsTDGGASWTR 297
Cdd:pfam13088  78 AGSKIYRITSSDNGRTWSAPRRLPPGPFLNISGPVKnkpvqLADGRLLLPSYHE---LAGKWAAHLELS--DDGGVTWRK 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893  298 RTGVLHTPQAMRPIstetdrpgtrlggfVLVHGAleqpdgtllQSAYGYYaNDRTYRQLLLASTDGGRDWT-VRSTV--- 373
Cdd:pfam13088 153 GRPDNAISGELQPS--------------VLVLAD---------GRLVMLF-RSQEGAILASESTDGGLTWSpPEPTNlpn 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521986893  374 --AAQGGGQgyaegafahTADGALLAVMRTGDY----RPMVAARSTDDGRTWDPPQVLRSGSG 430
Cdd:pfam13088 209 pnSGIDAVN---------LPDGRLLLVYNPPNAgkprGPLALALSEDGGKSWEEVLTLEDGPG 262
COG4692 COG4692
Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane ...
 287-470 6.33e-07

Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443727 [Multi-domain]  Cd Length: 353  Bit Score: 51.47  E-value: 6.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 287 VSTDGGASWTRRTGVLHTPqamrpistetdrpgTRLGGFVLVHgALEQPDGTLLqsAYGYYANDRTYRQLLLASTDGGRD 366
Cdd:COG4692  136 TSTDGGKTWSPPERLPEGP--------------FLIGGPVRNK-PVVLSDGRIL--LPSYTESGGKWRSHVEISDDGGKT 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 367 WTVRSTVAAQGGGQGyaegAFAHTADGALLAVMRTGDYRPMVAARSTDDGRTWDPPQVLrsgsgELP--------VTsiy 438
Cdd:COG4692  199 WTKSPIPKGFGAIQP----SILELKDGRLQALMRSRGAGRIYRSESTDGGKTWSPPEAT-----DLPnpnsgidaVT--- 266

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 521986893 439 pvlepLPGGRLALL--------TGRPGLRLYTSRD-GIRWS 470
Cdd:COG4692  267 -----LKDGRLLLVynptsaggGGRTPLSLALSDDeGKTWK 302
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
 212-382 1.17e-06

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 50.70  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 212 RMSYPAHTDDSAGAGNRYVYSDDGGRSWTTdrsGNPMPSVPSVNLTK---LSGGTLLAtnyhtYLRTGSSTeASVETSVS 288
Cdd:COG4409  193 RLVFPAYYSDGGKPSAAVIYSDDHGKTWKL---GESANDKANTNEAQvveLSDGRLML-----NMRNQSGG-GKRAVATS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 289 TDGGASWTRRTGV--LHTPQAMRPISTETDRPGTRLggfvlvhgaleqpdgtLLQSAygyyANDRTYRQLLL--ASTDGG 364
Cdd:COG4409  264 KDGGETWSEVTFDpaLPEPVCQASIIRYDKGDGKDV----------------LLFSN----PASPKGRKNGTvrLSYDDG 323

                        170
                 ....*....|....*...
gi 521986893 365 RDWTVRSTVaaQGGGQGY 382
Cdd:COG4409  324 KTWPYSKVI--EPGGSAY 339
COG4692 COG4692
Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane ...
 223-425 1.19e-06

Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443727 [Multi-domain]  Cd Length: 353  Bit Score: 50.70  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 223 AGAGNRYVYSDDGGRSWTTDR---SGNPMPSVPSVN-LTKLSGGTLLATNYHtylRTGSSTEASVEtsVSTDGGASWTRr 298
Cdd:COG4692  128 WGSLIRVRTSTDGGKTWSPPErlpEGPFLIGGPVRNkPVVLSDGRILLPSYT---ESGGKWRSHVE--ISDDGGKTWTK- 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 299 tgvlhtpqamRPIStetdrpgtrlGGFVLVHGA-LEQPDGTLLqsAYGYYAN-DRTYRQLllaSTDGGRDWT-VRST--- 372
Cdd:COG4692  202 ----------SPIP----------KGFGAIQPSiLELKDGRLQ--ALMRSRGaGRIYRSE---STDGGKTWSpPEATdlp 256

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521986893 373 -----VAAqgggqgyaegafAHTADGALLAV----MRTGDYR-PMVAARSTDDGRTWDPPQVL 425
Cdd:COG4692  257 npnsgIDA------------VTLKDGRLLLVynptSAGGGGRtPLSLALSDDEGKTWKDVRVL 307
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
 229-452 1.48e-06

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 50.32  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 229 YVYSDDGGRSWTTDRSGNPMPSVPSVNL------------TKLSGGTLLATNYHTylrtgSSTEASVETSVSTDGGASWT 296
Cdd:COG4409  147 VTYSDDDGKTWSEPRNITPQVKDPDWRFlatgpghgiqlkNGEHKGRLVFPAYYS-----DGGKPSAAVIYSDDHGKTWK 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 297 RRTGVLHTPQamrpiSTETdrpgtrlggfVLVhgalEQPDGTLLQSAygyYANDRTYRQLLLASTDGGRDWTVRSTVAA- 375
Cdd:COG4409  222 LGESANDKAN-----TNEA----------QVV----ELSDGRLMLNM---RNQSGGGKRAVATSKDGGETWSEVTFDPAl 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 376 -------------QGGGQGYAegAFAHTADgallavmrTGDYRPMVAARSTDDGRTWDPPQVLRSGSgelpvtSIYPVLE 442
Cdd:COG4409  280 pepvcqasiirydKGDGKDVL--LFSNPAS--------PKGRKNGTVRLSYDDGKTWPYSKVIEPGG------SAYSCLT 343

                        250
                 ....*....|
gi 521986893 443 PLPGGRLALL 452
Cdd:COG4409  344 VLDDGTIGLL 353
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 210-406 2.12e-06

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 49.76  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 210 RIRMSYPAHTDDSAGAGNRYVYSDDGGRSWTtdRSGNPMPSVPSVN---LTKLSGGTLLAtNYHTYLRTGSSTEAsvets 286
Cdd:cd15482  157 RLVFPAYARNGGGGGDGAVVIYSDDGGKTWT--RGGGVPSSGAGGDepsIVELSDGRLLM-NARNSGGGGGRAVA----- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 287 VSTDGGASWTRRTGVLHTPQAMRPISTETDRPGTRlggfvlvhgaleqpdGTLLQSAYGYYANDRTyRQLLLASTDGGRD 366
Cdd:cd15482  229 ESTDGGETWSEPVPTPSLPDPGCQGSLIRLPDGGR---------------KVLLFSNPASPGKGRT-NLTLRLSDDGGKT 292

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 521986893 367 WTVRSTVAAqggGQGYAEGAFAHTADGALLAVMRTGDYRP 406
Cdd:cd15482  293 WPDVRVLED---GPGSGYSSLTQLPDGTIGLLYEEGRGGG 329
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 223-419 2.99e-06

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 47.30  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 223 AGAGNRYVYSDDGGRSWTTDRSGNPMPSVPSV---NLTKLSGGTLLATNYHtylrtgssteasvetsvSTDGGASWTRrt 299
Cdd:COG4447    9 VGASGGILRSTDGGKTWTPLSDGLPGLSLRAVafsDPNTVWVGTGPGGIYR-----------------STDGGKTWTE-- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 300 gVLHTPQAMRPISTETDRPGTrlgGFVLVHGaleqpdgtllqsaygyyandrtyrqlLLASTDGGRDWTVRST------- 372
Cdd:COG4447   70 -VNSGPDNPRLFAIAFSDPNT---GYAAVGG--------------------------IYRTTDGGKTWTKVSSglpvdln 119

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 521986893 373 -VAAQGGGQGYA---EGAFAHTADGallavmrtGDYrpmvaaRSTDDGRTW 419
Cdd:COG4447  120 dVAFLDPGTLYAageGGLIYRSTDG--------GEY------RSTDGGKTW 156
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 335-509 1.11e-04

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 44.37  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 335 PDGTLLQSAYG--YYANDRTYRQLLLA--STDGGRDWTVRSTVAAQGGGQGYAEG---AFAHTADGALLAVM-------- 399
Cdd:cd15482   23 PNGTLLAFADGryEGAGDLGGDIDIVVrrSTDGGKTWSEPVTVVDGGGSGGASYGdpsLVVDPDTGRIFLFYtsgpgggg 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 400 --RTGDYRPMVA-ARSTDDGRTWDPPqvlrsgsgelpvTSIYPVLEPLPGGRLALLTGRpGLRLytsRDGiRWSAPVSVD 476
Cdd:cd15482  103 eaLTGDGTVRVRlSTSDDDGKTWSEP------------RDLTPQVKPSGWKFFFTGPGR-GIQL---SDG-RLVFPAYAR 165

                        170       180       190
                 ....*....|....*....|....*....|...
gi 521986893 477 YRNSGNGtmvrtGNSLLVFGDRGANWARPAPAP 509
Cdd:cd15482  166 NGGGGGD-----GAVVIYSDDGGKTWTRGGGVP 193
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
 386-474 2.50e-03

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 40.30  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986893 386 AFAHTADGALLAVmrtGDYRP-----------MVAARSTDDGRTWDPPQVLRSGSGELPVTSIY----PVLEPLPG---- 446
Cdd:COG4409   41 ALVTTPKGTLLAF---ADARYngsgdlpgdidIVMRRSTDGGKTWSPPQVILDYGEGGGLSAGVgdpaPVVDRKTGrifl 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 521986893 447 --------------GRLALLTGRPGLRLY--TSRD-GIRWSAPVS 474
Cdd:COG4409  118 ladwmpgndgegwsGSEPGTDPKGTRQLWvtYSDDdGKTWSEPRN 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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