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Conserved domains on  [gi|521986894|ref|WP_020498165|]
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MDR family MFS transporter [Sciscionella marina]

Protein Classification

MDR family MFS transporter( domain architecture ID 13024942)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0016020|GO:0055085|GO:0022857
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 18-412 4.91e-76

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 241.70  E-value: 4.91e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLGGYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAIS 97
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  98 PNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGA 177
Cdd:cd17502   81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 178 TALLLLLRYLReqrpqtthridypGAVLVLLASGALFLWIteggtawawlsapslvllgggilallaavfaerraaepiv 257
Cdd:cd17502  161 LALALLRTILL-------------SSIFGFLFGGALFGLI---------------------------------------- 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 258 ppwiwsrralagsclataglgllligpsTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIG-FRDTALI 336
Cdd:cd17502  188 ----------------------------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVI 239

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521986894 337 GALLAIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAV 412
Cdd:cd17502  240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 18-412 4.91e-76

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 241.70  E-value: 4.91e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLGGYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAIS 97
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  98 PNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGA 177
Cdd:cd17502   81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 178 TALLLLLRYLReqrpqtthridypGAVLVLLASGALFLWIteggtawawlsapslvllgggilallaavfaerraaepiv 257
Cdd:cd17502  161 LALALLRTILL-------------SSIFGFLFGGALFGLI---------------------------------------- 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 258 ppwiwsrralagsclataglgllligpsTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIG-FRDTALI 336
Cdd:cd17502  188 ----------------------------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVI 239

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521986894 337 GALLAIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAV 412
Cdd:cd17502  240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-345 1.08e-40

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 152.15  E-value: 1.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   17 ALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCA 95
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGsSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   96 ISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPI 175
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  176 GATALLLLLRYLREQRPQTTHRIDYPGAVLVLLASGALFLWITEGGtAWAWLSAPSLVLLGGGILALLAA-VFAERRAAE 254
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGP-ERGWFDSNEILILSITGLVAIIAfVVWELTDDN 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  255 PIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTA 334
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324

                         330
                  ....*....|.
gi 521986894  335 LIGALLAIAGS 345
Cdd:TIGR00711 325 TIGLILYAVGF 335
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-408 1.03e-39

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 146.27  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   6 TGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGI 84
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  85 LVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYAS 164
Cdd:COG2814   83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 165 WRWIFLVNLPIGATALLLLLRYLREQRPqtthridypgavlvllasgalflwiteggtawawlsapslvllgggilalla 244
Cdd:COG2814  163 WRWVFLVNAVLALLALLLLLRLLPESRP---------------------------------------------------- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 245 avfaERRAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARC 324
Cdd:COG2814  191 ----AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 325 YLRIGFRDTALIGALLAIAGsavLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYL 404
Cdd:COG2814  267 ADRFGRRRLLLIGLLLLALG---LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                 ....
gi 521986894 405 GSGL 408
Cdd:COG2814  344 GGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
18-410 3.48e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 117.13  E-value: 3.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   18 LVATMALAAMDTTIVATAVPQLVGDLGGY--TLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCA 95
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGIspTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   96 ISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNlpi 175
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  176 gatalllllrylreqrpqtthridypgAVLVLLASGALFLWITeggtawawlsaPSLVLLGGGILALLAAVFAERRAAEP 255
Cdd:pfam07690 158 ---------------------------AILSLLAAVLLLLPRP-----------PPESKRPKPAEEARLSLIVAWKALLR 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  256 IVPPWIWSRRALAGSCLAtaglgllliGPSTFLPTYaQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTAL 335
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFF---------GLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521986894  336 IGALLAIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGA 410
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_efflux_LmrA NF000031
lincomycin efflux MFS transporter Lmr(A);
3-416 1.92e-28

lincomycin efflux MFS transporter Lmr(A);


Pssm-ID: 411074 [Multi-domain]  Cd Length: 484  Bit Score: 117.46  E-value: 1.92e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   3 DARTGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLGGYTL-FSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLL 81
Cdd:NF000031  21 DEAARSRSRWVTLVFLAVLQLLIAVDVTVVNIALPAIRDSFHVDTRqLTWVVTGYTVVGGGLLMVGGRIADLFGRRRTLL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  82 AGILVFLLGSALCAISPNMVLLVVFRAVQGIGAG----GAQSMIATVASDlysVAERGRVQGWLSSVWGVSAILGPLLGG 157
Cdd:NF000031 101 FGAFLFGASSLAAGLAPNLELLVLARFGQGAGEAlslpAAMSLIALLFPE---TAARSKALSVWASVASVGLVLGFLLSG 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 158 AFAEYASWRWIFLVNLPIGATALLLLLRYLREQRPQTTHRIDYPGAVLVLLASGALFLWITEGGTAWAWLSApSLVLLGG 237
Cdd:NF000031 178 VITQLFSWRWIFLINIPLVSLVLVAVLLLVKKDETTARNPVDLPGALLFTAAPLLLIFGVIELGEDEPRLPL-AVGSLLA 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 238 GILALLAAVFAERRAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLA 317
Cdd:NF000031 257 AAVCAAAFVAVERRTAHPLVPLTFFGNRVRLVANGATVLLSAALSTSFFLLTMHLQEERDLSPIEAGLSFLPLALSLILA 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 318 SALSARCYLRIGFRDTALIGALLAIAGSAVLFALPDPGSVWQCIL-AVALLGGGFGLISASLLIGMQAGVGWSERGVVTG 396
Cdd:NF000031 337 SLLVPRLIERIGTTGAAVLGMALAALGIGCFALLPSDNSLLTSVFpGMILLACGMATGLVALQNAALHAVTEADAGVASG 416

                        410       420
                 ....*....|....*....|
gi 521986894 397 ANQFARYLGSGLGAAVYGAV 416
Cdd:NF000031 417 VQRCADQLGGASGIAVYVSI 436
PRK10504 PRK10504
putative transporter; Provisional
 26-215 7.95e-20

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 91.72  E-value: 7.95e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  26 AMDTTIVATAVPQLVGDLGGYTL-FSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLV 104
Cdd:PRK10504  23 SLDTTIVNTALPSMAQSLGESPLhMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 105 VFRAVQGIGAG-----GAQSMIATVASDLYSVAergrvQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGATA 179
Cdd:PRK10504 103 LARVLQGVGGAmmvpvGRLTVMKIVPREQYMAA-----MTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIG 177

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 521986894 180 LLLLLRYLREQRPQtTHRIDYPGAVLVLLASGALFL 215
Cdd:PRK10504 178 AIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTL 212
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 18-412 4.91e-76

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 241.70  E-value: 4.91e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLGGYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAIS 97
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  98 PNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGA 177
Cdd:cd17502   81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 178 TALLLLLRYLReqrpqtthridypGAVLVLLASGALFLWIteggtawawlsapslvllgggilallaavfaerraaepiv 257
Cdd:cd17502  161 LALALLRTILL-------------SSIFGFLFGGALFGLI---------------------------------------- 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 258 ppwiwsrralagsclataglgllligpsTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIG-FRDTALI 336
Cdd:cd17502  188 ----------------------------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVI 239

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521986894 337 GALLAIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAV 412
Cdd:cd17502  240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 18-430 1.04e-49

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 173.51  E-value: 1.04e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLGG-YTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAI 96
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGAsPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  97 SPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIG 176
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 177 ATALLLLLRylreqrpqtthridYPGAVLVLLASGALFlwiteggtawawlsapslvllgggilallaavfaerraaepi 256
Cdd:cd17321  161 LVALLLART--------------FSGAVLAAFLLGAAL------------------------------------------ 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 257 vppwiwsrralagsclataglglllIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALI 336
Cdd:cd17321  185 -------------------------GGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 337 GALLAIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAVYGAV 416
Cdd:cd17321  240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319

                        410
                 ....*....|....
gi 521986894 417 SNASTETGHGPRAV 430
Cdd:cd17321  320 LTAGLSANLGDSGV 333
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 22-441 5.07e-44

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 158.89  E-value: 5.07e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  22 MALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNM 100
Cdd:cd17503    5 AFMAILDTTIVNVALPTIMGDLGaSLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 101 VLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIgatal 180
Cdd:cd17503   85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI----- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 181 llllrylreqrpqtthridypGAVLVLLAsgalflwiteggtawawlsapslvllgggilallaavfaerraaePIVPPW 260
Cdd:cd17503  160 ---------------------GILALLLA---------------------------------------------PLLDLR 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 261 IWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALIGALL 340
Cdd:cd17503  174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 341 AIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAVYGAV---- 416
Cdd:cd17503  254 LALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLltnr 333

                        410       420       430
                 ....*....|....*....|....*....|..
gi 521986894 417 -------SNASTETGHGPRAVYAGTHHVFLAM 441
Cdd:cd17503  334 tqfhhsrLSELLAQQVQKQALIIAFNDAFLVS 365
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-345 1.08e-40

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 152.15  E-value: 1.08e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   17 ALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCA 95
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGsSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   96 ISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPI 175
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  176 GATALLLLLRYLREQRPQTTHRIDYPGAVLVLLASGALFLWITEGGtAWAWLSAPSLVLLGGGILALLAA-VFAERRAAE 254
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGP-ERGWFDSNEILILSITGLVAIIAfVVWELTDDN 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  255 PIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTA 334
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324

                         330
                  ....*....|.
gi 521986894  335 LIGALLAIAGS 345
Cdd:TIGR00711 325 TIGLILYAVGF 335
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-408 1.03e-39

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 146.27  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   6 TGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGI 84
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  85 LVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYAS 164
Cdd:COG2814   83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 165 WRWIFLVNLPIGATALLLLLRYLREQRPqtthridypgavlvllasgalflwiteggtawawlsapslvllgggilalla 244
Cdd:COG2814  163 WRWVFLVNAVLALLALLLLLRLLPESRP---------------------------------------------------- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 245 avfaERRAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARC 324
Cdd:COG2814  191 ----AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 325 YLRIGFRDTALIGALLAIAGsavLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYL 404
Cdd:COG2814  267 ADRFGRRRLLLIGLLLLALG---LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                 ....
gi 521986894 405 GSGL 408
Cdd:COG2814  344 GGPL 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 14-425 2.55e-36

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 137.71  E-value: 2.55e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  14 VLAALVATMALAAMdttiVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSA 92
Cdd:cd17504    1 LALAALAVMLVETM----LSPALPTIQREFGtSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  93 LCAISPNMVLLVVFRAVQGIGaGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVN 172
Cdd:cd17504   77 LAAFAPNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 173 LPIGATALllllrylreqrpqtthridypgavlvllasgalflwiteggtawawlsapslvllgggilallaavfaerrA 252
Cdd:cd17504  156 APVAVLLA-----------------------------------------------------------------------A 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 253 AEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQS----LLGLGPIAAGLVLSTMSLTWPLASALSARCYLRI 328
Cdd:cd17504  165 LVPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARV 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 329 GFRDTALIGALLAIAGSAVLFALPDpgSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGL 408
Cdd:cd17504  245 GPRRVLLIGLVISAVGLLLLALLHS--SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAI 322

                        410
                 ....*....|....*..
gi 521986894 409 GAAVYGAVSNASTETGH 425
Cdd:cd17504  323 GPAIAGAILTTYTVSIT 339
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 4-288 1.19e-33

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 128.39  E-value: 1.19e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   4 ARTGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLA 82
Cdd:COG0477    5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  83 GILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEY 162
Cdd:COG0477   85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 163 ASWRWIFLVNLPIGATALLLLLRYLREQRPQTTHRIDYPGAVLVLLASGALFLWITEGGTAWAWLSAPSLVLLGGGILAL 242
Cdd:COG0477  165 LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 521986894 243 LAAVFAERRAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFL 288
Cdd:COG0477  245 LLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 20-430 4.56e-32

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 128.51  E-value: 4.56e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  20 ATMALAAMDTTIV----ATAVPQLVGDLGGYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCA 95
Cdd:cd06179    1 AALCLAYFAQLFGvtlpAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  96 ISPNMVLLVVFRAVQGIGAGGAQSMIAtVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAE--YASWRWIFLVNL 173
Cdd:cd06179   81 TAKSVNMLIGGQALIGIGAGTQGLGAA-VASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYINA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 174 PIGATALLL---------LLRYLREQRPQTTHRIDYPGAVLVLLASGALFLWITEGGTAWAWLSAPSLVLLGGGILALLA 244
Cdd:cd06179  160 IFNALALILlfffyhpppRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLIA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 245 AVFAERRAA-EPIVPPWIWSR-RALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSA 322
Cdd:cd06179  240 FGLYEWKGTkDGLLPPRLLFRgRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 323 RCYLRIGFRDTALIGALLAIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFAR 402
Cdd:cd06179  320 LLLTKIKHIKWQLVAGFVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSAR 399

                        410       420
                 ....*....|....*....|....*...
gi 521986894 403 YLGSGLGAAVYGAVSNASTETgHGPRAV 430
Cdd:cd06179  400 ALGGAVGTAIFTSILSNRLSK-NLPARV 426
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 18-419 1.35e-30

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 121.91  E-value: 1.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAI 96
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGaSVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  97 SPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVnlpig 176
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV----- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 177 atalllllrylreqrpqtthridypGAVLVLLASGALFLWITEGGTawawlSAPSLVLLGGGILALLAAVFaerraaepi 256
Cdd:cd17325  156 -------------------------CAALALLALVLALLLLPEPRP-----PPNKRAVSAARLRSGLRLLL--------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 257 vppwiwSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALI 336
Cdd:cd17325  197 ------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 337 GALLaiaGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAVYGAV 416
Cdd:cd17325  271 GLLL---SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347


                 ...
gi 521986894 417 SNA 419
Cdd:cd17325  348 YDA 350
MFS_1 pfam07690
Major Facilitator Superfamily;
18-410 3.48e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 117.13  E-value: 3.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   18 LVATMALAAMDTTIVATAVPQLVGDLGGY--TLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCA 95
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGIspTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   96 ISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNlpi 175
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  176 gatalllllrylreqrpqtthridypgAVLVLLASGALFLWITeggtawawlsaPSLVLLGGGILALLAAVFAERRAAEP 255
Cdd:pfam07690 158 ---------------------------AILSLLAAVLLLLPRP-----------PPESKRPKPAEEARLSLIVAWKALLR 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  256 IVPPWIWSRRALAGSCLAtaglgllliGPSTFLPTYaQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTAL 335
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFF---------GLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521986894  336 IGALLAIAGSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGA 410
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 18-420 1.47e-28

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 116.14  E-value: 1.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAI 96
Cdd:cd17320    4 LALLVALGPLAIDMYLPALPAIARDLGaSASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  97 SPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNlpig 176
Cdd:cd17320   84 ASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL---- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 177 atalllllrylreqrpqtthridypgAVLVLLASGALFLWITEGgtawawLSAPSLVLLGGGILALLAAVFAERRAAepi 256
Cdd:cd17320  160 --------------------------ALLGLLLLLLVLLFLPET------LPEEKRKPLLSSLLRAYKRVLKNRRFL--- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 257 vppwiwsRRALAGSCLATAGLGLLLIGPSTFlptyaQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALI 336
Cdd:cd17320  205 -------GYALALGLSFAGLFAYLAAAPFIY-----IEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRL 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 337 GALLAIAGSAVL--FALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGwSERGVVTGANQFARYLGSGLGAAVYG 414
Cdd:cd17320  273 GLLLLLAAALVLllAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVG 351


                 ....*.
gi 521986894 415 AVSNAS 420
Cdd:cd17320  352 LLPNGT 357
MFS_efflux_LmrA NF000031
lincomycin efflux MFS transporter Lmr(A);
3-416 1.92e-28

lincomycin efflux MFS transporter Lmr(A);


Pssm-ID: 411074 [Multi-domain]  Cd Length: 484  Bit Score: 117.46  E-value: 1.92e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   3 DARTGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLGGYTL-FSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLL 81
Cdd:NF000031  21 DEAARSRSRWVTLVFLAVLQLLIAVDVTVVNIALPAIRDSFHVDTRqLTWVVTGYTVVGGGLLMVGGRIADLFGRRRTLL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  82 AGILVFLLGSALCAISPNMVLLVVFRAVQGIGAG----GAQSMIATVASDlysVAERGRVQGWLSSVWGVSAILGPLLGG 157
Cdd:NF000031 101 FGAFLFGASSLAAGLAPNLELLVLARFGQGAGEAlslpAAMSLIALLFPE---TAARSKALSVWASVASVGLVLGFLLSG 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 158 AFAEYASWRWIFLVNLPIGATALLLLLRYLREQRPQTTHRIDYPGAVLVLLASGALFLWITEGGTAWAWLSApSLVLLGG 237
Cdd:NF000031 178 VITQLFSWRWIFLINIPLVSLVLVAVLLLVKKDETTARNPVDLPGALLFTAAPLLLIFGVIELGEDEPRLPL-AVGSLLA 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 238 GILALLAAVFAERRAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLA 317
Cdd:NF000031 257 AAVCAAAFVAVERRTAHPLVPLTFFGNRVRLVANGATVLLSAALSTSFFLLTMHLQEERDLSPIEAGLSFLPLALSLILA 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 318 SALSARCYLRIGFRDTALIGALLAIAGSAVLFALPDPGSVWQCIL-AVALLGGGFGLISASLLIGMQAGVGWSERGVVTG 396
Cdd:NF000031 337 SLLVPRLIERIGTTGAAVLGMALAALGIGCFALLPSDNSLLTSVFpGMILLACGMATGLVALQNAALHAVTEADAGVASG 416

                        410       420
                 ....*....|....*....|
gi 521986894 397 ANQFARYLGSGLGAAVYGAV 416
Cdd:NF000031 417 VQRCADQLGGASGIAVYVSI 436
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 15-417 3.33e-28

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 114.98  E-value: 3.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  15 LAALVATMAlaamdTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSAL 93
Cdd:cd17474    6 FATLLAVLG-----VSIVDPILPAIAEALGaSPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  94 CAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEyASWRWIFLvnl 173
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFF--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 174 pigatalllllrylreqrpqtthridypgavLVLLASGALFLwiteggtAWAWLSAPSLVLLGGGILALLAAVFAerraa 253
Cdd:cd17474  157 -------------------------------LLAALIPVAFL-------AILFLLPEPKEKAKSSSATKLRDLKK----- 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 254 epivppwIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARcYLRIGFRD- 332
Cdd:cd17474  194 -------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR-LLKKRFGAr 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 333 TALIGALLAIAGSAVLFALPDpgSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAV 412
Cdd:cd17474  266 RILVIGLLLYALSLLLLGFVP--SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLL 343


                 ....*
gi 521986894 413 YGAVS 417
Cdd:cd17474  344 FGLLL 348
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 15-421 3.45e-24

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 103.42  E-value: 3.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  15 LAALVATMALAAMDTTIVATAVPQLVGDLGGY--TLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSA 92
Cdd:cd17473    1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNseLLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  93 LCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYaSWRWIFLVn 172
Cdd:cd17473   81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLV- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 173 lpigatalllllrylreqrpqtthridYPGAVLVLLAsgalflwiteggtAWAWLSAPSLVLLGGGILAllaavfAERRA 252
Cdd:cd17473  159 ---------------------------YLLALPVLIL-------------VLLFLPEPARKSKSAASPG------AATAA 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 253 AEPIVPPWIWSRRALAGSCLATAGLgllligpsTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRD 332
Cdd:cd17473  193 ALPWKRVLPIYFLAFLAMLLFYVIP--------IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 333 TALIGALLAIAGSAVLFALPdpgSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAV 412
Cdd:cd17473  265 LLAIGFALMALGFLLLALAS---GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341


                 ....*....
gi 521986894 413 YGAVSNAST 421
Cdd:cd17473  342 LGPLVNLTG 350
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
4-420 6.60e-24

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 102.64  E-value: 6.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   4 ARTGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLA 82
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  83 GILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEY 162
Cdd:COG2271   81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 163 ASWRWIFLVNLPIGatalllllrylreqrpqtthridypgavLVLLASGALFLWITEGGTAWAWLsapslvllgggilal 242
Cdd:COG2271  161 FGWRAAFLILGLPG----------------------------LLLALLRFWLLALAYFLVYFALY--------------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 243 laavfaerraaepivppwiwsrralagsclataglgllliGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSA 322
Cdd:COG2271  198 ----------------------------------------GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGG 237

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 323 RCYLRIGFRDTALIGALLAIAGsAVLFALPDPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFAR 402
Cdd:COG2271  238 WLSDRLGRRRKLVLAIGLLLAA-LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG 316

                        410
                 ....*....|....*...
gi 521986894 403 YLGSGLGAAVYGAVSNAS 420
Cdd:COG2271  317 FLGGALGPLLVGYLLDAT 334
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 17-177 1.74e-20

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 92.64  E-value: 1.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  17 ALVATMALA-AMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALC 94
Cdd:cd17323    2 FIISFLTFVvTFGSSIYSPALPQIAEDFHvSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  95 AISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLP 174
Cdd:cd17323   82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161


                 ...
gi 521986894 175 IGA 177
Cdd:cd17323  162 ISG 164
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 50-416 2.06e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 92.61  E-value: 2.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  50 SWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLY 129
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 130 SVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNlpigatalllllrylreqrpqtthridypgAVLVLLA 209
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI------------------------------AVLALLA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 210 SGALFLWIteggtawawlsaPSLVLLGGGILALLAAVFAerraaepivppwIWSRRALAGSCLATAGLGLLLIGPSTFLP 289
Cdd:cd17324  167 ALLLWRLL------------PSLPPKKPGSLGLLSSLLL------------LLRNPRLRLAYLITFLLFGGFFALYTYLA 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 290 TYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALIGALLAIAGSAVLFALPDPGSVwqcILAVALLGG 369
Cdd:cd17324  223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLL---LVGLVLWGL 299

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 521986894 370 GFGLISASL--LIGMQAGVGwseRGVVTGANQFARYLGSGLGAAVYGAV 416
Cdd:cd17324  300 GFFAAHSALqtRVLRLAPEA---RGLASSLYLAAYNLGGALGAALGGLV 345
PRK10504 PRK10504
putative transporter; Provisional
 26-215 7.95e-20

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 91.72  E-value: 7.95e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  26 AMDTTIVATAVPQLVGDLGGYTL-FSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLV 104
Cdd:PRK10504  23 SLDTTIVNTALPSMAQSLGESPLhMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 105 VFRAVQGIGAG-----GAQSMIATVASDLYSVAergrvQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGATA 179
Cdd:PRK10504 103 LARVLQGVGGAmmvpvGRLTVMKIVPREQYMAA-----MTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIG 177

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 521986894 180 LLLLLRYLREQRPQtTHRIDYPGAVLVLLASGALFL 215
Cdd:PRK10504 178 AIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTL 212
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 52-417 2.76e-19

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 89.19  E-value: 2.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  52 VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSV 131
Cdd:cd17489   36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 132 AERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVnlpigatalllllrylreqrpqtthridypGAVLVLLASG 211
Cdd:cd17489  116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV------------------------------AAVLALLALL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 212 ALFLwiteggtawawlsapslvllgggiLALLAAVFAERRAAEPIVPPWIWSRRALAgSCLATAGLGLLLIGPSTFLPTY 291
Cdd:cd17489  166 LVFL------------------------VKDPPPVAAEEAEAGTRAFRRLVEKKVLP-PALILFLASIAYGAISTFLPLY 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 292 AQSllgLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALIGALLAIAGsavLFALPDPGSVWQCILAVALLGGGF 371
Cdd:cd17489  221 AAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG---LLLLSFAGSPWMLLLAAVLYGLGF 294

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 521986894 372 GLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAVYGAVS 417
Cdd:cd17489  295 GLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
2_A_01_02 TIGR00880
Multidrug resistance protein;
50-173 3.33e-19

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 83.85  E-value: 3.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   50 SWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLY 129
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 521986894  130 SVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNL 173
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
emrD PRK11652
multidrug transporter EmrD;
12-197 3.86e-18

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 86.11  E-value: 3.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  12 GKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLG 90
Cdd:PRK11652   7 VNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNvREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  91 SALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFL 170
Cdd:PRK11652  87 TLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYL 166

                        170       180
                 ....*....|....*....|....*..
gi 521986894 171 VNLPIGATALLLLLRYLREQRPQTTHR 197
Cdd:PRK11652 167 FLLLLGAGVTFSMARWMPETRPADARR 193
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 18-171 4.01e-18

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 85.32  E-value: 4.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLGGYTL----FSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSAL 93
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGAsgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521986894  94 CAISPNMVLLVVFRAVQGIGaGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 24-193 5.35e-18

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 85.51  E-value: 5.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   24 LAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVL 102
Cdd:TIGR00710  16 LGPLGIDMYLPAFPEIAADLStPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIET 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  103 LVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGATALLL 182
Cdd:TIGR00710  96 LLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSAL 175

                         170
                  ....*....|.
gi 521986894  183 LLRYLREQRPQ 193
Cdd:TIGR00710 176 IFFILPETLPY 186
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
9-420 1.45e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 81.08  E-value: 1.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   9 TGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVF 87
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGlSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  88 LLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRW 167
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 168 IFLVnlpigatalllllrylreqrpqtthridypgAVLVLLASGALFLWITEGGTAWAWLSAPSLVLLGGGilallaavf 247
Cdd:COG2223  161 AFLI-------------------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE--------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 248 aerraaepivppwIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLR 327
Cdd:COG2223  201 -------------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 328 IGFRDTALIGALLAIAGSAVLFALpdPGSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSG 407
Cdd:COG2223  268 IGGRRVLLIVFALMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGF 345

                        410
                 ....*....|...
gi 521986894 408 LGAAVYGAVSNAS 420
Cdd:COG2223  346 LGPLLFGALLDAT 358
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 15-380 4.83e-16

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 79.18  E-value: 4.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  15 LAALVATMALAAMDTTIVATAVPQLVGDLGGYT---LFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGS 91
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLsllQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  92 ALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGA----FAEYASWRW 167
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLliplLSGDWGWRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 168 IFLVnlpigatalllllrylreqrpqtthridypGAVLVLLAsgalflwiteggtawawlsapslvllgggilallaavf 247
Cdd:cd17316  161 LFLI------------------------------GALPALLA-------------------------------------- 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 248 aerraaepivppwIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLR 327
Cdd:cd17316  173 -------------LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR 239

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 521986894 328 IGFRDTALIGALLAIAgSAVLFALPDPGSVWQCILAVALLGGGFGLISASLLI 380
Cdd:cd17316  240 IGRKKTLVIGLILSGI-LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA 291
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 11-171 1.07e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.39  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  11 RGKVLAALVATMALAAMDTTIVATAVPQLVGDLGGYTLF--SWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFL 88
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqiGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  89 LGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWI 168
Cdd:cd17325  277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356


                 ...
gi 521986894 169 FLV 171
Cdd:cd17325  357 FLA 359
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-421 1.80e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.85  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  22 MALAAMDTTIVATAVPQLVGDLGGYT-LFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNM 100
Cdd:cd06174    5 FFLTGLARGLISPLLPALLQSFGLSAsQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 101 VLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEY--ASWRWIFLVNlpigat 178
Cdd:cd06174   85 WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIA------ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 179 alllllrylreqrpqtthridypgAVLVLLASGALFLWITEggtawawlsaPSLVLLGGGILALLAAVFAERRAaepivp 258
Cdd:cd06174  159 ------------------------AALALLAAILLLLVVPD----------PPESARAKNEEASSKSVLKLLKR------ 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 259 pwIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALIGA 338
Cdd:cd06174  199 --VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG 276

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 339 LLAIAGSAVLFALPDPGSVWqcILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAVYGAVSN 418
Cdd:cd06174  277 LLLMALGLALLLLAPSLLLL--LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354


                 ...
gi 521986894 419 AST 421
Cdd:cd06174  355 ATF 357
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 15-162 1.22e-14

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 75.36  E-value: 1.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  15 LAALVATMALAAMDTTIVATAVPQLVGDLGGYT-----LFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLL 89
Cdd:cd17388    1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSadaatHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521986894  90 GSALCAISPNMVLLVVFRAVQGI-GAGGAQSmiATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEY 162
Cdd:cd17388   81 DYLLMAFAPTLWWLYLGRIIAGItGATGAVA--AAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI 152
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 16-169 2.00e-14

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 74.61  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  16 AALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALC 94
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGtSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521986894  95 AISPNMVLLVVFRAVQGIGAGGaqsMIATVASDLYSVAERGRVQGWLSSVWGVSA----ILGPLLGGAFAEYASWRWIF 169
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAF---LLPNAMALLGRTYPPGPRKNIVFSLFGATAplgfALGGVFGGLFAQLAWWPWIF 156
PRK14995 PRK14995
SmvA family efflux MFS transporter;
14-414 2.56e-14

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 74.76  E-value: 2.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  14 VLAALVATMALAAMDTTIVATAVPQLVGDLG--GYTLFsWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGS 91
Cdd:PRK14995   7 TLVIIVLVYIPVAIDATVLHVAAPTLSMTLGasGNELL-WIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  92 ALCAISPNMVLLVVFRAVQGIGAggAQSMIATVASDLYSVAE---RGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWI 168
Cdd:PRK14995  86 LAAAFSPTASWLIATRALLAIGA--AMIVPATLAGIRATFTEekqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 169 FLVNLPIGATALLLLLRYLREQRPQTTHRIDYPGAVLVLLasgALFLWITEGGTAWAWLSAPSLVLLGGGILALLAAVF- 247
Cdd:PRK14995 164 FLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIV---AILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFi 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 248 -AERRAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYL 326
Cdd:PRK14995 241 rTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 327 RIGFRDTALIGALLAIAGSAVLFALPDPGSVWQCILAVALLGGGfglISASLLIGMQA--GVGWSERGVVTGANQFARY- 403
Cdd:PRK14995 321 RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFS---AASALLASTSAimAAAPPEKAAAAGAIETMAYe 397

                        410
                 ....*....|.
gi 521986894 404 LGSGLGAAVYG 414
Cdd:PRK14995 398 LGAGLGIAIFG 408
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
15-420 5.05e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 73.35  E-value: 5.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  15 LAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSAL 93
Cdd:COG0738   10 LIAIYLLFFLWGFATALWGPLIPALKDAFGlSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  94 CAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSvAERGRVQGWLSSVWGVSAILGPLLGGAFAEY---ASWRWIFL 170
Cdd:COG0738   90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 171 VNlpigatalllllrylreqrpqtthridypGAVLVLLASGALFLWITEGGTAwawlsapslvllgggilallaavfAER 250
Cdd:COG0738  169 IL-----------------------------AVLLLLLALLFLRSKLPEIEEE------------------------EEE 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 251 RAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIGF 330
Cdd:COG0738  196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 331 RDTALIGALLAIAGSAVLFALPdpgSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFArYLGSGLGA 410
Cdd:COG0738  276 VRLLRLSALLAAVGLLLALLAP---GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGP 351

                        410
                 ....*....|
gi 521986894 411 AVYGAVSNAS 420
Cdd:COG0738  352 PLIGFLADAF 361
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 54-226 5.91e-14

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 73.42  E-value: 5.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  54 SAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAE 133
Cdd:cd17328   41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 134 RGRVQGWLSSVWGVSAILGPLLGGAFAEYA-SWRWIFLVNLPIGATALLLLLRYLREQRP--------QTTHRIDYpGAV 204
Cdd:cd17328  121 RTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRgaaeggvmAKSTATSF-LAD 199

                        170       180
                 ....*....|....*....|..
gi 521986894 205 LVLLASGALFLWITEGGTAWAW 226
Cdd:cd17328  200 LKALAKNPSFILSTLGFTAVSF 221
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 36-162 5.51e-13

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 69.95  E-value: 5.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  36 VPQLVGDLGG-YTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIgA 114
Cdd:cd17390   19 LSTHIRSLGAsPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI-F 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 521986894 115 GGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEY 162
Cdd:cd17390   98 KHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAET 145
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
54-171 5.51e-13

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 70.33  E-value: 5.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  54 SAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAE 133
Cdd:PRK11102  33 SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEE 112

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 521986894 134 RGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:PRK11102 113 FSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV 150
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 14-171 2.81e-12

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 67.98  E-value: 2.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  14 VLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSA 92
Cdd:cd17319    4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGlSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521986894  93 LCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17319   84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 21-171 9.38e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 66.07  E-value: 9.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  21 TMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPN 99
Cdd:cd17365    7 IIVLDGFDLAVMGFVAPALAQDWGlSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521986894 100 MVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17365   87 VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 52-171 1.71e-11

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 65.64  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  52 VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSV 131
Cdd:cd17370  239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 521986894 132 AERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17370  319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
53-169 5.90e-11

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 63.89  E-value: 5.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  53 FSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVA 132
Cdd:PRK10473  44 FSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDR 123

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 521986894 133 ERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIF 169
Cdd:PRK10473 124 RRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-171 5.98e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 63.91  E-value: 5.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894    1 MIDARTGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLGGYTL-FSWVFSAYLLAQTVTIPVYGKLGDLYGRKPV 79
Cdd:TIGR00895   5 NIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVqLGFLFSAGLIGMAFGALFFGPLADRIGRRRV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   80 LLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAF 159
Cdd:TIGR00895  85 LLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164

                         170
                  ....*....|..
gi 521986894  160 AEYASWRWIFLV 171
Cdd:TIGR00895 165 IPVFGWRSLFYV 176
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
66-218 1.73e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 62.60  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGA----QSMIAtvasDLYSVAERGRVQGWL 141
Cdd:PRK11043  60 LWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAaviwQALVI----DRYPAQKANRVFATI 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 142 SSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGATALLLLLRYLREQRP--QTTHRID---------YPGAVLVLLA- 209
Cdd:PRK11043 136 MPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKArkQSQDALTfkqllksktYLGNVLIFAAc 215


                 ....*....
gi 521986894 210 SGALFLWIT 218
Cdd:PRK11043 216 SAAFFAWLT 224
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 22-171 2.66e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.84  E-value: 2.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  22 MALAAMDTTIVATAVPQLVGDLGgYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMV 101
Cdd:cd17489  203 LFLASIAYGAISTFLPLYAAERG-ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPW 281

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 102 LLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17489  282 MLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLL 351
Sugar_tr pfam00083
Sugar (and other) transporter;
46-175 3.82e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 61.90  E-value: 3.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   46 YTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMV---LLVVFRAVQGIGAGGAQSMIA 122
Cdd:pfam00083  45 SVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGGASVLAP 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 521986894  123 TVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEY-ASWRWIFLVNLPI 175
Cdd:pfam00083 125 MYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTsNSDGWRIPLGLQL 178
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 66-175 4.71e-10

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 61.64  E-value: 4.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVW 145
Cdd:PRK03893  74 LLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGF 153

                         90       100       110
                 ....*....|....*....|....*....|.
gi 521986894 146 GVSAILGPLLGGAFAEYASWRWIFLVN-LPI 175
Cdd:PRK03893 154 SIGAVVAAQVYSLVVPVWGWRALFFIGiLPI 184
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
50-170 6.14e-10

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 60.72  E-value: 6.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  50 SWV---FSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGgaqsMIATV-- 124
Cdd:PRK15402  48 EWVptsMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC----FIGAVgy 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 521986894 125 ASDLYSVAERG--RVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFL 170
Cdd:PRK15402 124 AAIQESFEEADaiKITALMANVALLAPLLGPLVGAALIHVLPWRGMFV 171
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 33-215 6.25e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 60.69  E-value: 6.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  33 ATAVPQLVG-DLGGYTLFSWVFSayllaqtvtIPvYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQG 111
Cdd:cd17472   27 PGATPTLIGlALGIYGLTQAIFQ---------IP-FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 112 IGAggaqsmIATVA----SDLYSVAERGRVQGWLSSVWGVSA----ILGPLLGGAFaeyaSWRWIFLVNLPIGATALLLL 183
Cdd:cd17472   97 SGA------ISSVVmallADLTREENRTKAMALIGASIGIAFaismVLGPLLAAHL----GVSGLFLITAILSLVSLLIL 166

                        170       180       190
                 ....*....|....*....|....*....|..
gi 521986894 184 LRYLREQRPQTTHRIDYPGAVLVLLASGALFL 215
Cdd:cd17472  167 LFFVPDPPKIVQISEKEKKKLKKLLKNKRLLR 198
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
4-416 8.96e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 60.27  E-value: 8.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   4 ARTGTTGRGKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLA 82
Cdd:COG2807    9 RRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGlSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  83 GILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSvAERGRVQGWLSSVWGVSAILGPLLGGAFAEY 162
Cdd:COG2807   89 ALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 163 ASWRWIFlvnlpigatalllllrylreqrpqtthridypgAVLVLLASGALFLWIteggtaWAWLSAPSlvllgggilal 242
Cdd:COG2807  168 LGWRGAL---------------------------------AVWALLALLALLLWL------PLLRRRPA----------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 243 laavfAERRAAEPIVPPWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSlLGLGPIAAGLVLSTMSLTWPLASALSA 322
Cdd:COG2807  198 -----AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVP 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 323 RCYLRIG-FRDTALIGALLAIAGSAVLFALPDPGSvwqcILAVALLGGGFG-LISASLLIGMQAGVGWSERGVVTGANQF 400
Cdd:COG2807  272 LLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLP----WLWAVLLGLGQGgLFPLALTLIGLRARTPAEAAALSGMAQS 347

                        410
                 ....*....|....*.
gi 521986894 401 ARYLGSGLGAAVYGAV 416
Cdd:COG2807  348 VGYLLAALGPLLVGAL 363
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 31-171 1.51e-09

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 59.59  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  31 IVATAVPQLVGDLGGYTLFS-WVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAV 109
Cdd:cd17391  223 ILTLYIRQLMGDASNLAFISgLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFL 302

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 521986894 110 QGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17391  303 LGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
14-171 1.69e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 59.50  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  14 VLAALVATMALAAMDTTIVATA------VPQLVGDLGGYTLF--SWVFSAYLLAQTVTIPVYGKLGDLYGR--KPVLLAG 83
Cdd:COG2271  175 LLLALLRFWLLALAYFLVYFALygfltwLPTYLVEVRGLSLAqaGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  84 ILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYA 163
Cdd:COG2271  255 LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334


                 ....*...
gi 521986894 164 SWRWIFLV 171
Cdd:COG2271  335 GYQAAFLL 342
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 52-171 3.09e-09

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 58.43  E-value: 3.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  52 VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAG---GAQSMIATVASDL 128
Cdd:cd17391   41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGyvpNATALIASQTPKE 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 521986894 129 YSvaerGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17391  121 KS----GWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
76-416 4.12e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 58.37  E-value: 4.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  76 RKPVLLAGILVFLLGSALCAISPNM----------VLLVVFRAVQGIGAGGAQSMIATVASDlysVAERGRVQGWLSSVW 145
Cdd:COG2211   80 RRPWILIGAIPLALSFVLLFTAPDLsptgkliyalVTYLLLGLAYTLVNIPYSALGAELTPD---YEERTRLSSWRFAFA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 146 GVSAILGPLLGGAFAEY------ASWRWIFLVnlpigatalllllrylreqrpqtthridypGAVLVLLASGALFLWITE 219
Cdd:COG2211  157 GLGGLLASVLPPPLVAAfggdaaLGYRLTALI------------------------------FAVLGLLAFLLTFFGTKE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 220 ggtawawlsAPSLVLLGGGILALLAAVFAERraaepivpPWIWsrraLAGSCLATAGLGLLligPSTFLPTYAQSLLGLG 299
Cdd:COG2211  207 ---------RPVPEEEKVSLKESLKALLKNR--------PFLL----LLLAYLLFFLALAL---VAALLLYYFKYVLGLS 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 300 PIAAGLVLSTMSLTWPLASALSARCYLRIGFRDTALIGALLAIAGSAVLFALPdPGSVWQCILAVALLGGGFGLISAsLL 379
Cdd:COG2211  263 AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG-PGNLWLLLVLAALAGIGLGAILV-LP 340

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 521986894 380 IGMQAGV--------GWSERGVVTGANQFARYLGSGLGAAVYGAV 416
Cdd:COG2211  341 WAMLADVvdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 15-171 5.63e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 57.96  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  15 LAALVATMA--LAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGS 91
Cdd:cd17359    1 LISLVAALGglLFGYDTGVINGALPFLQTDFNlTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  92 ALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGW--------LSSVWGVSAILGPLLGGAFAEYA 163
Cdd:cd17359   81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADWLGAE 160


                 ....*...
gi 521986894 164 SWRWIFLV 171
Cdd:cd17359  161 GWRWMLGL 168
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 23-171 8.62e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 57.31  E-value: 8.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  23 ALAAMDTTIVATAVPQLV----------GDLGGYTLFSWVFSAYLlaqtvtipvYGKLGDLYGRKPVLLAGILVFLLGSA 92
Cdd:cd17371    9 ALDGFDLLLLGLVLPALIaefgldeaeaGLLGTVTLAGGAIGGIL---------GGILADRFGRVRVLVITILLFAVFTL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  93 LCAISPNMVLLVVFRAVQGIGAGG----AQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWI 168
Cdd:cd17371   80 LCGFAQNYWQLLILRALAGLGFGGewaaGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVL 159


                 ...
gi 521986894 169 FLV 171
Cdd:cd17371  160 FLL 162
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 54-160 1.98e-08

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 56.13  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  54 SAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVAsDLYSVAE 133
Cdd:cd17389   71 SLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVA-DVTSPKK 149

                         90       100
                 ....*....|....*....|....*..
gi 521986894 134 RGRVQGWLSSVWGVSAILGPLLGGAFA 160
Cdd:cd17389  150 RSKGMALIGVAFSLGFIIGPMIGAYFA 176
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 48-174 2.79e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 55.28  E-value: 2.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  48 LFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASD 127
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 521986894 128 LYSVAERGRVQGWLSSVWGVSAILGPLLGGAFaeyASWRWI-FLVNLP 174
Cdd:cd17317  106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLI---RDWRWLqLAISLP 150
PRK12307 PRK12307
MFS transporter;
67-173 5.13e-08

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 54.93  E-value: 5.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  67 YGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWG 146
Cdd:PRK12307  73 FGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFG 152

                         90       100
                 ....*....|....*....|....*..
gi 521986894 147 VSAILGPLLGGAFAEYASWRWIFLVNL 173
Cdd:PRK12307 153 IGNIIAAYFMPSFAEAYGWRAAFFVGL 179
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 65-179 6.39e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 55.02  E-value: 6.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   65 PVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSV 144
Cdd:TIGR00898 145 FVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF 224

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 521986894  145 WGVSAILGPLLGgafaeYA--SWRWI-FLVNLPIGATA 179
Cdd:TIGR00898 225 FSLGLVLLPLVA-----YFipDWRWLqLAVSLPTFLFF 257
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 5-171 8.15e-08

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 54.20  E-value: 8.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   5 RTGTTGRGKVLAALVATMALAAM---DTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVL 80
Cdd:PRK11551   4 RTSSASSSRLALTIGLCFLVALLeglDLQSAGVAAPRMAQEFGlDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRIL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  81 LAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFA 160
Cdd:PRK11551  84 IVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAA 163

                        170
                 ....*....|.
gi 521986894 161 EYASWRWIFLV 171
Cdd:PRK11551 164 GDAAWRHIFYV 174
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 19-175 9.47e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 53.73  E-value: 9.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  19 VATMA--LAAMDTTIVATAVPQLVGDLGGY---TLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSAL 93
Cdd:cd17315    1 VAALGglLFGYDLGVINGALLYIAKDLGFGlstSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  94 CAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRvqgwLSSVWGVSAILGPLL----GGAFAEYASWRWIF 169
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGA----LGTLNQLMITFGILLayllGLALSLSPPGWWRL 156


                 ....*.
gi 521986894 170 LVNLPI 175
Cdd:cd17315  157 MFALAA 162
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 33-259 1.01e-07

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 54.29  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   33 ATAVPQLVGDLGGYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGI 112
Cdd:pfam06609  64 ASALPNILQDIGQSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  113 GAGGAQSMIATVASDLysvAERGRVQGWL--SSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGATALLLLLRYLREQ 190
Cdd:pfam06609 144 AAGPAGASPLFIGELM---SNKTKFLGLLivSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYHPP 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  191 RPQTTH-----------RIDYPGAVLVLLASGALFLWITEGGTAWA-WLSAPSLVLLGGGILALLAAVFAE--RRAAEPI 256
Cdd:pfam06609 221 SFAQLHgkkarkrdelaKLDWIGIFLVIAGTSLFLLGVSWGGKPNNpWNSAKIIGLISSGAGSLVIFALYEvfGKPEQPI 300


                  ...
gi 521986894  257 VPP 259
Cdd:pfam06609 301 IPP 303
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 28-177 2.25e-07

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 53.11  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   28 DTTIVATAVPQLVGDLGG---------YTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSAL---CA 95
Cdd:TIGR00879  43 DTGVIGGALALPAFEFKFtsansdsysSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILmglAA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   96 ISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRvqgwLSSVWGVSAILGPLLGGAFAEYA-------SWRWI 168
Cdd:TIGR00879 123 FALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGA----LTSLYQLAITFGILVAYGFGSGKvslnntlGWRIP 198


                  ....*....
gi 521986894  169 FLVNLPIGA 177
Cdd:TIGR00879 199 LGLQLIPAG 207
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 15-419 6.18e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.46  E-value: 6.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  15 LAALVATMALAAMDTTIVATAVPQLVGDLGGY-TLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLA-----GILVFL 88
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSaLLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  89 LGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWI 168
Cdd:cd06173   81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 169 FLVNlpigatalllllrylreqrpqtthridypgAVLVLLASGALFLWIteggtawawlsAPSLVLLGGGILALLAAVFA 248
Cdd:cd06173  161 FAIN------------------------------ALSFLLSALLLLFIR-----------RPPPAAPGESSSLLLRDLRE 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 249 ERRaaepivppWIWSRRALAGSCLATAGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRI 328
Cdd:cd06173  200 GLR--------YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 329 GFRDTALIGALLAIAGSAVLFALPdpgSVWQCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGL 408
Cdd:cd06173  272 RRGRLLLIGALLLGLALLVLGLSP---SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348

                        410
                 ....*....|.
gi 521986894 409 GAAVYGAVSNA 419
Cdd:cd06173  349 GALLAGLLADA 359
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 65-416 7.35e-07

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 51.54  E-value: 7.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  65 PVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSV 144
Cdd:cd17322   55 PPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLP 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 145 WGVSAILGPLLGGAFAEYASWRWIF--------LVNLPIG---------ATALLLLLRYLREQRPQTTH----------- 196
Cdd:cd17322  135 YIITTWIGGNIAQAALPNSNWRWGYgmwaiilpLSSLPLVlcllymqrkARKDGEIKELKNQETEEQTGglsqnlvklfw 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 197 RIDYPGAVLVLLASGALFLWIT-EGGTAWAWLSAPSLVLLGGGILALLAAVFAE-RRAAEPIVPPWIWSRRALAGSCLAT 274
Cdd:cd17322  215 KLDIFGVILLTAGLGLILVPLTlAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEaKFAKYPFLPFRLLKDRTILAACLID 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894 275 AGLGLLLIGPSTFLPTYAQSLLGLGPIAAGLVLSTMSLTWPLASALSARCYLRIG-FRDTALIGALLAIAGSAVLFALPD 353
Cdd:cd17322  295 FFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrYKVLVIIGVPLYIVGMGLLIRYRG 374

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521986894 354 PGSVW-QCILAVALLGGGFGLISASLLIGMQAGVGWSERGVVTGANQFARYLGSGLGAAVYGAV 416
Cdd:cd17322  375 GSGSHgGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAI 438
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 51-171 9.26e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 50.65  E-value: 9.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  51 WVFSAYLLAQTVTIPVYGKLGDL-YGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLY 129
Cdd:cd17474  238 LLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 521986894 130 SVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17474  318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV 359
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 28-169 1.05e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 50.73  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  28 DTTIVATAVPQLVGDLGGYTLFSW----VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLL 103
Cdd:cd17360   12 DTGVISGALLYIKDDLGEVVLSTGwqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 521986894 104 VVFRAVQGIGAGGAqSMIATVasdLYSVAERGRVQGWLSSVWGVSAILGPLL----GGAFAEY-ASWRWIF 169
Cdd:cd17360   92 IVGRVLVGLGVGIA-SMTVPL---YIAEAAPPRIRGRLVTINVLFITGGQFVayviNGAFSYLpGGWRWML 158
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-163 1.43e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.29  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  14 VLAALVATMALAAMDTTIVATAVpQLVGDlgGYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSAL 93
Cdd:COG2211  234 LLAYLLFFLALALVAALLLYYFK-YVLGL--SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521986894  94 CAISP--NMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAE-------RGRVQGWLSSVWGVSAILGPLLGGAFAEYA 163
Cdd:COG2211  311 LFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALF 389
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
68-169 2.93e-06

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 49.44  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  68 GKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAggaqSMIATVA----SDLYSVAERGRVQGWLSS 143
Cdd:PRK15403  72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSI----CFIATVGyvtvQEAFGQTKGIKLMAIITS 147

                         90       100
                 ....*....|....*....|....*.
gi 521986894 144 VWGVSAILGPLLGGAFAEYASWRWIF 169
Cdd:PRK15403 148 IVLVAPIIGPLSGAALMHFVHWKVLF 173
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 33-171 3.64e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 48.81  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  33 ATAVPQLVGDLGGYTLF-SWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQG 111
Cdd:cd17312   23 SVAKPPIVEEIGLSKDDlGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521986894 112 IgaggAQSM----IATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17312  103 L----FQSMgwppCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV 162
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 27-171 6.09e-06

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 48.49  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   27 MDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVV 105
Cdd:TIGR00893   8 LDRANLSFAAPMLQEDLGlSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521986894  106 FRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:TIGR00893  88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFII 153
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 45-172 8.29e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.99  E-value: 8.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  45 GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATV 124
Cdd:cd17329   33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAM 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 521986894 125 ASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYaSWRWIFLVN 172
Cdd:cd17329  113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAA 159
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 26-176 8.37e-06

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 47.89  E-value: 8.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  26 AMDTTIVATAVPQLVGDlggYTLFSW--------VFSAYLLAQTVtipvYGKLGDLYGRKPVLLAGILVFLLGSALCAIS 97
Cdd:cd17441   12 AMEMMILSILAPQLHCE---WRLPSWqvalltsvVFIGMMLSSSL----WGNISDQYGRKTGLKISVLWTLYYGILSAFA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  98 PNMVLLVVFRAVQGIGAGGA-QSMiaTVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWI-FLVNLPI 175
Cdd:cd17441   85 PIYSWILVLRGLVGFGIGGVpQSV--TLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLlILSALPL 162


                 .
gi 521986894 176 G 176
Cdd:cd17441  163 L 163
MFS_1 pfam07690
Major Facilitator Superfamily;
11-153 9.67e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 9.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   11 RGKVLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLL 89
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGlSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521986894   90 GSALCAISP---NMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGP 153
Cdd:pfam07690 278 AALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 68-174 1.18e-05

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 47.35  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  68 GKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERgRVQGWLSSVWGV 147
Cdd:cd17379   54 GYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYR-RTVGIVYQMFFT 132

                         90       100
                 ....*....|....*....|....*...
gi 521986894 148 SAILgpLLGGAFAEYASWRWIFL-VNLP 174
Cdd:cd17379  133 LGLL--ILPGIAYFIPHWRWLQLaVTLP 158
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 66-155 1.88e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 46.89  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPN------MVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQG 139
Cdd:cd17364   58 FFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIA 137

                         90
                 ....*....|....*.
gi 521986894 140 WLSSVWGVSAILGPLL 155
Cdd:cd17364  138 AVFAMQGFGILAGAIV 153
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 68-147 2.33e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 46.47  E-value: 2.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  68 GKLGDLYGRKPVLLAGILVFLLGSAL-CAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGW--LSSV 144
Cdd:cd17356   66 SFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLyqLAIT 145


                 ...
gi 521986894 145 WGV 147
Cdd:cd17356  146 IGI 148
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 66-172 2.85e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.03  E-value: 2.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVW 145
Cdd:cd17330  230 LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ 309

                         90       100
                 ....*....|....*....|....*..
gi 521986894 146 GVSAILGPLLGGAFAEYASWRWIFLVN 172
Cdd:cd17330  310 SLARIIGPLLAGPLYSFLGPGVPFLLA 336
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 52-179 3.17e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.06  E-value: 3.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  52 VFSAYLLAQT-VTIPVyGKLGDLYG-RKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASdLY 129
Cdd:cd17490   36 ILGAYGISQMlLRIPL-GILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS-YF 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 521986894 130 SVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLVNLPIGATA 179
Cdd:cd17490  114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLG 163
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 68-157 5.16e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 45.43  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   68 GKLGDLYGRKPV----LLAGILVFLLGSALcaISPNMVLLVVFraVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSS 143
Cdd:TIGR00895 306 GWLADRLGPRVTalllLLGAVFAVLVGSTL--FSPTLLLLLGA--IAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIG 381

                          90
                  ....*....|....
gi 521986894  144 VWGVSAILGPLLGG 157
Cdd:TIGR00895 382 IGRLGAIIGPILAG 395
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 52-171 1.46e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 43.90  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894   52 VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSV 131
Cdd:TIGR00881  35 LLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSR 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 521986894  132 AERGRVQGWLSSVWGVS-AILGPLLGGAFAEYASWRWIFLV 171
Cdd:TIGR00881 115 SERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIV 155
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 51-171 1.50e-04

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 43.72  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  51 WVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAG----GAQSMIATVAS 126
Cdd:cd17384   35 LLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSAcssvAGMGMLASLYP 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 521986894 127 DlysVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17384  115 D---DKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLI 156
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 16-171 1.57e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 43.70  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  16 AALVATMALAAMDTTIVATAVPQLVGDLGGYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGS-ALC 94
Cdd:cd17477  192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAAlLLP 271

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521986894  95 AISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17477  272 LVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLF 348
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 14-171 2.09e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 43.31  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  14 VLAALVATMALAAmDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSA 92
Cdd:cd17380    1 VILLFLATCICYA-DRVNMPIAIVPMAKEFGwSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  93 LC--AISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFL 170
Cdd:cd17380   80 LTplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159


                 .
gi 521986894 171 V 171
Cdd:cd17380  160 F 160
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 50-171 2.79e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 42.91  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  50 SWVFSAYLLAQTVtipvYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAqSMIATVASDLY 129
Cdd:cd17372   41 SVVFAGMMIGSYL----WGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGG-PQLASWYLEFL 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 521986894 130 SVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17372  116 PAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAF 157
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
52-171 2.96e-04

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 42.99  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  52 VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAG---GAQSMIATVASDL 128
Cdd:PRK09874  59 VFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGfvpNANALIATQVPRN 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 521986894 129 YSvaerGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:PRK09874 139 KS----GWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFI 177
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 18-159 5.58e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.16  E-value: 5.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  18 LVATMALAAMDTTIVATAVPQLVGDLGGYTLF-SWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAI 96
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALiGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521986894  97 SPNMVLLVVFRAVQGIGAGG----AQSMIATVASDlysvAERGRVQGWLSSVWGVSAILGPLLGGAF 159
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGlfvvSESWLNALATN----ENRGRVLGLYSTVLGLGFALGPLLLALV 143
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 14-171 7.20e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.82  E-value: 7.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  14 VLAALVATMALAAMDTTIVATAVPQLVGDLG-GYTLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSA 92
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGvDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  93 LCAISPNMVLLVVFR--AVQGIGAGGAQsmiaTVASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFL 170
Cdd:cd17331   81 LLAFASSVPMLFLSRlpSVFMHAMQAAQ----MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAAL 156


                 .
gi 521986894 171 V 171
Cdd:cd17331  157 V 157
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 47-156 7.42e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 41.90  E-value: 7.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  47 TLFSW-VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNM--------VLLVVFRAVQGIGAGGA 117
Cdd:cd17367   39 LLSTAaVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiwapIILLLARLLQGLSVGGE 118

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 521986894 118 QSMIATVASDLYSVAERGRVQGWLSsvwgVSAILGPLLG 156
Cdd:cd17367  119 YGTSATYLSEVAPPGRRGFYSSFQY----VTLIGGQLLA 153
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 47-160 7.67e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 41.81  E-value: 7.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  47 TLFSWVFSAYLLAQTVTIPVYGKLGD-LYGRKPVLLAGILVFLLGSALCAI-----SPNMVLLVVFRAVQGIGAGgaqsM 120
Cdd:cd17326   36 SFFGWVVAAYSLGQLVFSPVFGYWSNkTSSVKEPLIVSILIAIVGNILYALaeyfpSNRKYVMLVARFLIGVGAG----N 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 521986894 121 IATV---ASDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFA 160
Cdd:cd17326  112 VAVLrayVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT 154
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 50-171 1.25e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.15  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  50 SWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLY 129
Cdd:cd17333   34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 521986894 130 SvAERGRVQGWLSSVWGVSAILGPLLGGAF-AEYASWRWIFLV 171
Cdd:cd17333  114 E-ESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLI 155
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 66-159 1.35e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 41.07  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAER--GRVQGWLSS 143
Cdd:cd17313  300 PIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqGTDTGLLNL 379

                         90
                 ....*....|....*.
gi 521986894 144 VWGVSAILGPLLGGAF 159
Cdd:cd17313  380 AISLAQILVSLLAGPI 395
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 66-168 2.10e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 40.55  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVW 145
Cdd:cd17363   53 VWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFW 132

                         90       100
                 ....*....|....*....|...
gi 521986894 146 gvsailgpLLGGAFAEYASWRWI 168
Cdd:cd17363  133 --------MIGGLYASAMAWAII 147
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 68-135 2.51e-03

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 40.08  E-value: 2.51e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 521986894  68 GKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQsMIATVAS-DLYSVAERG 135
Cdd:cd17437   53 GRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFAL-MIAPVYTaEVAPASSRG 120
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 49-171 2.69e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 39.87  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  49 FSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDL 128
Cdd:cd17358   43 FSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEI 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 521986894 129 YSVAERGRvqgwLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17358  123 APKNVRGA----LGSLNQLLVNIGILLGYVLGSFLPWRTLALI 161
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 47-171 2.81e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.95  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  47 TLFSWVFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNM-VLLVVFRAVQGIGAGGAQSMIATVA 125
Cdd:cd17355   38 AVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLwQLYLLWGLLGGGGAGTLAAVAFATV 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 521986894 126 SDLYSVAERGRVQGWLSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17355  118 AAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 66-125 2.86e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.82  E-value: 2.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNM--------VLLVVFRAVQGIGAGGAQSMIATVA 125
Cdd:cd17369   63 VFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMA 130
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
 66-176 2.95e-03

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 39.65  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNM--------VLLVVFRAVQGIGAG----GAQSMIATVASD-----L 128
Cdd:cd17366   59 VFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYatigvwapILLLLARMVQGFSTGgeygGAATFVAEYAPDrkrgfL 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 521986894 129 YSVAERGRVQGWLSSVwGVSAILGPLLGGAFAEYASWRWIFLVNLPIG 176
Cdd:cd17366  139 GSWLEFGTLAGFILGA-GLVTLLTLLLTEAQMLDWGWRIPFLIAAPLG 185
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 74-117 3.54e-03

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 39.54  E-value: 3.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 521986894  74 YGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGA 117
Cdd:cd17361   78 WGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFG 121
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 54-171 4.61e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 39.20  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  54 SAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAE 133
Cdd:cd17374   42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRH 121

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 521986894 134 RGRVQGWLSSVWGVSAILgpLLGGAFAeYASWRWIFLV 171
Cdd:cd17374  122 RALAITLTSCFFSIGQML--LAGLAYA-IRDWRLLQLV 156
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 48-169 5.78e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 38.75  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  48 LFSWVFSAYLLAQtvtIPVyGKLGDLYGRKPVLLAGILVfllGSALCAISP-----NMVLLVVFRAVQGIGAGGAQSMIA 122
Cdd:cd17318   61 ILSSFFYGYILTQ---IPG-GYLAEKYGAKRVLGYSILI---TALLTLLTPlaargGYGALIVLRILQGLAQGVTFPAMH 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 521986894 123 TVASDLYSVAERGRvqgwLSSVWGVSAILGP----LLGGAFAEYASWRWIF 169
Cdd:cd17318  134 ALWAKWAPPLERSR----LTSIAYSGSQFGTviamPLSGFLCESLGWPSIF 180
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 65-171 6.02e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.75  E-value: 6.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  65 PVYGKLGDLYGRKPVLlagILVFLLGSALCAISP----NMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGW 140
Cdd:cd17353  267 PFWGWLSDKIGRKNTL---SIAFLIQGVAMFLLPfigsVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGL 343

                         90       100       110
                 ....*....|....*....|....*....|.
gi 521986894 141 LSSVWGVSAILGPLLGGAFAEYASWRWIFLV 171
Cdd:cd17353  344 LYTAKGVGGLIGPIIAAYVLYTGGYNAAFII 374
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 66-168 6.18e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 39.14  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  66 VYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAQSMIATVASDLYSVAERGRVQGWLSSVW 145
Cdd:cd17438   53 IWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFW 132

                         90       100
                 ....*....|....*....|...
gi 521986894 146 gvsailgpLLGGAFAEYASWRWI 168
Cdd:cd17438  133 --------MIGGLYASAMAWSII 147
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 52-176 7.36e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 38.49  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521986894  52 VFSAYLLAQTVTIPVYGKLGDLYGRKPVLLAGILVFLLGSALCAISPNMVLLVVFRAVQGIGAGGAqSMIATVASDLYSV 131
Cdd:cd17362   44 VVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLA-MHAAPVYIAETSP 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 521986894 132 AergRVQGWLSSVWGVSAILGPLLgGAFAEYA------SWRWIFLVNLPIG 176
Cdd:cd17362  123 S---HIRGLLVSLKELFIVLGILL-GYVSGYAfadvvgGWRYMYGLAAPPA 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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