TerC family protein [Thiofilum flexile]
Protein Classification
TerC family protein( domain architecture ID 11436733)
TerC family inner membrane protein similar to Escherichia coli YoaE and YegH, which contain a TerC domain, tandem repeats of the cystathionine beta-synthase (CBS pair) domain, and a transporter-associated domain
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| TerC | COG0861 | Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism]; |
1-224 | 1.92e-69 | |||||
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism]; : Pssm-ID: 440622 Cd Length: 225 Bit Score: 221.85 E-value: 1.92e-69
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| TlyC super family | cl34211 | Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ... |
247-513 | 8.80e-69 | |||||
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only]; The actual alignment was detected with superfamily member COG1253: Pssm-ID: 440865 [Multi-domain] Cd Length: 435 Bit Score: 226.92 E-value: 8.80e-69
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| Name | Accession | Description | Interval | E-value | |||||
| TerC | COG0861 | Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism]; |
1-224 | 1.92e-69 | |||||
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism]; Pssm-ID: 440622 Cd Length: 225 Bit Score: 221.85 E-value: 1.92e-69
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| TlyC | COG1253 | Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ... |
247-513 | 8.80e-69 | |||||
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only]; Pssm-ID: 440865 [Multi-domain] Cd Length: 435 Bit Score: 226.92 E-value: 8.80e-69
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| TerC | pfam03741 | Integral membrane protein TerC family; This family contains a number of integral membrane ... |
14-204 | 1.53e-46 | |||||
Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions. Pssm-ID: 461035 Cd Length: 178 Bit Score: 159.95 E-value: 1.53e-46
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| CBS_pair_CorC_HlyC_assoc | cd04590 | Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ... |
295-412 | 9.01e-33 | |||||
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase). Pssm-ID: 341366 [Multi-domain] Cd Length: 119 Bit Score: 121.06 E-value: 9.01e-33
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| PRK15094 | PRK15094 | magnesium/cobalt transporter CorC; |
275-512 | 3.79e-30 | |||||
magnesium/cobalt transporter CorC; Pssm-ID: 185050 [Multi-domain] Cd Length: 292 Bit Score: 119.14 E-value: 3.79e-30
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| CorC_HlyC | smart01091 | Transporter associated domain; This small domain is found in a family of proteins with the ... |
428-507 | 1.97e-17 | |||||
Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates. Pssm-ID: 215020 [Multi-domain] Cd Length: 78 Bit Score: 76.71 E-value: 1.97e-17
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| R_switched_YjbE | TIGR03717 | integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element ... |
13-204 | 6.75e-17 | |||||
integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed. Pssm-ID: 163429 Cd Length: 176 Bit Score: 78.36 E-value: 6.75e-17
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| CorC_HlyC | pfam03471 | Transporter associated domain; This small domain is found in a family of proteins with the ... |
428-508 | 1.05e-15 | |||||
Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates. Pssm-ID: 460935 [Multi-domain] Cd Length: 81 Bit Score: 72.19 E-value: 1.05e-15
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| PRK14013 | PRK14013 | hypothetical protein; Provisional |
134-227 | 4.03e-03 | |||||
hypothetical protein; Provisional Pssm-ID: 237583 Cd Length: 338 Bit Score: 39.41 E-value: 4.03e-03
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| Name | Accession | Description | Interval | E-value | |||||
| TerC | COG0861 | Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism]; |
1-224 | 1.92e-69 | |||||
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism]; Pssm-ID: 440622 Cd Length: 225 Bit Score: 221.85 E-value: 1.92e-69
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| TlyC | COG1253 | Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ... |
247-513 | 8.80e-69 | |||||
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only]; Pssm-ID: 440865 [Multi-domain] Cd Length: 435 Bit Score: 226.92 E-value: 8.80e-69
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| CorB | COG4536 | Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion ... |
251-508 | 2.38e-50 | |||||
Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion transport and metabolism]; Pssm-ID: 443602 [Multi-domain] Cd Length: 420 Bit Score: 177.58 E-value: 2.38e-50
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| TerC | pfam03741 | Integral membrane protein TerC family; This family contains a number of integral membrane ... |
14-204 | 1.53e-46 | |||||
Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions. Pssm-ID: 461035 Cd Length: 178 Bit Score: 159.95 E-value: 1.53e-46
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| CorC | COG4535 | Mg2+ and Co2+ transporter CorC, contains CBS pair and CorC-HlyC domains [Inorganic ion ... |
277-515 | 2.18e-41 | |||||
Mg2+ and Co2+ transporter CorC, contains CBS pair and CorC-HlyC domains [Inorganic ion transport and metabolism]; Pssm-ID: 443601 [Multi-domain] Cd Length: 288 Bit Score: 149.88 E-value: 2.18e-41
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| CBS_pair_CorC_HlyC_assoc | cd04590 | Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ... |
295-412 | 9.01e-33 | |||||
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase). Pssm-ID: 341366 [Multi-domain] Cd Length: 119 Bit Score: 121.06 E-value: 9.01e-33
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| PRK15094 | PRK15094 | magnesium/cobalt transporter CorC; |
275-512 | 3.79e-30 | |||||
magnesium/cobalt transporter CorC; Pssm-ID: 185050 [Multi-domain] Cd Length: 292 Bit Score: 119.14 E-value: 3.79e-30
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| PRK11573 | PRK11573 | hypothetical protein; Provisional |
284-515 | 5.85e-25 | |||||
hypothetical protein; Provisional Pssm-ID: 236933 [Multi-domain] Cd Length: 413 Bit Score: 106.76 E-value: 5.85e-25
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| CorC_HlyC | smart01091 | Transporter associated domain; This small domain is found in a family of proteins with the ... |
428-507 | 1.97e-17 | |||||
Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates. Pssm-ID: 215020 [Multi-domain] Cd Length: 78 Bit Score: 76.71 E-value: 1.97e-17
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| R_switched_YjbE | TIGR03717 | integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element ... |
13-204 | 6.75e-17 | |||||
integral membrane protein, YjbE family; Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family commonly are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains protein YjbE from Bacillus subtilis. A transport function is proposed. Pssm-ID: 163429 Cd Length: 176 Bit Score: 78.36 E-value: 6.75e-17
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| CorC_HlyC | pfam03471 | Transporter associated domain; This small domain is found in a family of proteins with the ... |
428-508 | 1.05e-15 | |||||
Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates. Pssm-ID: 460935 [Multi-domain] Cd Length: 81 Bit Score: 72.19 E-value: 1.05e-15
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| YtoI | COG4109 | Predicted transcriptional regulator containing CBS domains [Transcription]; |
296-413 | 6.18e-08 | |||||
Predicted transcriptional regulator containing CBS domains [Transcription]; Pssm-ID: 443285 [Multi-domain] Cd Length: 135 Bit Score: 51.45 E-value: 6.18e-08
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| COG2524 | COG2524 | Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription]; |
295-414 | 7.32e-08 | |||||
Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription]; Pssm-ID: 442013 [Multi-domain] Cd Length: 206 Bit Score: 52.96 E-value: 7.32e-08
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| COG3448 | COG3448 | CBS-domain-containing membrane protein [Signal transduction mechanisms]; |
296-421 | 2.57e-05 | |||||
CBS-domain-containing membrane protein [Signal transduction mechanisms]; Pssm-ID: 442671 [Multi-domain] Cd Length: 136 Bit Score: 44.09 E-value: 2.57e-05
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| CBS_pair_DRTGG_assoc | cd04596 | Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ... |
304-377 | 4.38e-05 | |||||
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the DRTGG domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase). Pssm-ID: 341371 [Multi-domain] Cd Length: 108 Bit Score: 42.46 E-value: 4.38e-05
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| CBS_pair_SF | cd02205 | Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ... |
309-411 | 6.50e-05 | |||||
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase). Pssm-ID: 341358 [Multi-domain] Cd Length: 113 Bit Score: 42.23 E-value: 6.50e-05
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| CBS_pair_voltage-gated_CLC_euk_bac | cd04591 | Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ... |
299-406 | 8.28e-05 | |||||
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC voltage-gated chloride channel. The CBS pairs here are found in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of chloride ions across biological membranes. CIC-type chloride channels come from all kingdoms of life, have several gene families, and can be gated by voltage. The members of the CIC-type chloride channel are double-barreled: two proteins forming homodimers at a broad interface formed by four helices from each protein. The two pores are not found at this interface, but are completely contained within each subunit, as deduced from the mutational analyses, unlike many other channels, in which four or five identical or structurally related subunits jointly form one pore. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase). Pssm-ID: 341367 [Multi-domain] Cd Length: 114 Bit Score: 42.12 E-value: 8.28e-05
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| CBS | COG0517 | CBS domain [Signal transduction mechanisms]; |
296-417 | 1.81e-03 | |||||
CBS domain [Signal transduction mechanisms]; Pssm-ID: 440283 [Multi-domain] Cd Length: 128 Bit Score: 38.31 E-value: 1.81e-03
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| PRK14013 | PRK14013 | hypothetical protein; Provisional |
134-227 | 4.03e-03 | |||||
hypothetical protein; Provisional Pssm-ID: 237583 Cd Length: 338 Bit Score: 39.41 E-value: 4.03e-03
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| Blast search parameters | ||||
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