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Conserved domains on  [gi|522118167|ref|WP_020629376|]
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MULTISPECIES: Fur family transcriptional regulator [Amycolatopsis]

Protein Classification

Fur family transcriptional regulator( domain architecture ID 10002362)

Fur (ferric uptake regulator) family transcriptional regulator such as metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria

CATH:  3.30.1490.190|1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677|GO:0046872
PubMed:  17216355|24106689

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
14-136 5.53e-40

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


:

Pssm-ID: 440498  Cd Length: 140  Bit Score: 130.84  E-value: 5.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  14 GRRSTKQRAAVVELLKEIDDFRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHLV 93
Cdd:COG0735   15 GLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYELNEGDHHHHLI 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 522118167  94 CRLCGSTVEVEGPAVERWAEKIASEHGFSDISHTVEIVGTCSN 136
Cdd:COG0735   95 CTKCGKVIELDDDEIEELLEELAEPHGFEIESHELEIYGLCPD 137
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
14-136 5.53e-40

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 130.84  E-value: 5.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  14 GRRSTKQRAAVVELLKEIDDFRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHLV 93
Cdd:COG0735   15 GLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYELNEGDHHHHLI 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 522118167  94 CRLCGSTVEVEGPAVERWAEKIASEHGFSDISHTVEIVGTCSN 136
Cdd:COG0735   95 CTKCGKVIELDDDEIEELLEELAEPHGFEIESHELEIYGLCPD 137
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 19-134 2.41e-37

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 123.07  E-value: 2.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  19 KQRAAVVELLKEIDDFRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHLVCRLCG 98
Cdd:cd07153    1 PQRLAILEVLLESDGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDEHHHHLICTKCG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 522118167  99 STVEVEGPAVERWAEKIASEHGFSDISHTVEIVGTC 134
Cdd:cd07153   81 KVIDFEDCPLEELLEELAAKTGFKITSHRLELYGIC 116
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 14-130 7.91e-34

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 114.26  E-value: 7.91e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167   14 GRRSTKQRAAVVELLKEIDD-FRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHL 92
Cdd:pfam01475   3 GLKLTPQRLKILEVLQKSDKeHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHDHL 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 522118167   93 VCRLCGSTVEVEGPAVERWAEKIASEHGFSDISHTVEI 130
Cdd:pfam01475  83 ICEDCGKVIEFKDDEIEKRQEEIAKKHGFKLVSHRLEL 120
fur PRK09462
ferric uptake regulator; Provisional
 14-136 2.05e-12

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 60.13  E-value: 2.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  14 GRRSTKQRAAVVELLKEIDDFR-SAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHL 92
Cdd:PRK09462  12 GLKVTLPRLKILEVLQEPDNHHvSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQHHHDHL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 522118167  93 VCRLCGSTVEVEGPAVERWAEKIASEHGFSDISHTVEIVGTCSN 136
Cdd:PRK09462  92 ICLDCGKVIEFSDDSIEARQREIAAKHGIKLTNHSLYLYGHCAE 135
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
14-136 5.53e-40

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 130.84  E-value: 5.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  14 GRRSTKQRAAVVELLKEIDDFRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHLV 93
Cdd:COG0735   15 GLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYELNEGDHHHHLI 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 522118167  94 CRLCGSTVEVEGPAVERWAEKIASEHGFSDISHTVEIVGTCSN 136
Cdd:COG0735   95 CTKCGKVIELDDDEIEELLEELAEPHGFEIESHELEIYGLCPD 137
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 19-134 2.41e-37

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 123.07  E-value: 2.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  19 KQRAAVVELLKEIDDFRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHLVCRLCG 98
Cdd:cd07153    1 PQRLAILEVLLESDGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDEHHHHLICTKCG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 522118167  99 STVEVEGPAVERWAEKIASEHGFSDISHTVEIVGTC 134
Cdd:cd07153   81 KVIDFEDCPLEELLEELAAKTGFKITSHRLELYGIC 116
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 14-130 7.91e-34

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 114.26  E-value: 7.91e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167   14 GRRSTKQRAAVVELLKEIDD-FRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHL 92
Cdd:pfam01475   3 GLKLTPQRLKILEVLQKSDKeHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHDHL 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 522118167   93 VCRLCGSTVEVEGPAVERWAEKIASEHGFSDISHTVEI 130
Cdd:pfam01475  83 ICEDCGKVIEFKDDEIEKRQEEIAKKHGFKLVSHRLEL 120
fur PRK09462
ferric uptake regulator; Provisional
 14-136 2.05e-12

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 60.13  E-value: 2.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  14 GRRSTKQRAAVVELLKEIDDFR-SAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEIDVLRTDTGEAIYRRCSSHHHHHL 92
Cdd:PRK09462  12 GLKVTLPRLKILEVLQEPDNHHvSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQHHHDHL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 522118167  93 VCRLCGSTVEVEGPAVERWAEKIASEHGFSDISHTVEIVGTCSN 136
Cdd:PRK09462  92 ICLDCGKVIEFSDDSIEARQREIAAKHGIKLTNHSLYLYGHCAE 135
PRK11639 PRK11639
zinc uptake transcriptional repressor Zur;
14-135 1.75e-03

zinc uptake transcriptional repressor Zur;


Pssm-ID: 183251  Cd Length: 169  Bit Score: 36.66  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522118167  14 GRRSTKQRAAVVELLKEIDDFRSAQELHDELRKRGDGIGLTTVYRTLQSLSEAGEI-DVLRTDTgeaiYRRCS-----SH 87
Cdd:PRK11639  21 NVRLTPQRLEVLRLMSLQPGAISAYDLLDLLREAEPQAKPPTVYRALDFLLEQGFVhKVESTNS----YVLCHlfdqpTH 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 522118167  88 HHHHLVCRLCGSTVEVEGPAVERWAEKIASEHGFSdISHTV-EIVGTCS 135
Cdd:PRK11639  97 TSAMFICDRCGAVKEECAEGVEDIMHTLAAKMGFA-LRHNViEAHGLCA 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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