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Conserved domains on  [gi|523590335|ref|WP_020755708|]
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MULTISPECIES: Bax inhibitor-1/YccA family protein [Geobacillus]

Protein Classification

Bax inhibitor-1/YccA family protein( domain architecture ID 10179639)

Bax inhibitor-1/YccA family protein similar to Escherichia coli YccA, which negatively regulates the FtsH protease and is degraded by in an FtsH-dependent manner

Gene Ontology:  GO:0016020
PubMed:  18336295|18440869
TCDB:  1.A.14.2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 8-208 1.64e-32

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


:

Pssm-ID: 198414  Cd Length: 211  Bit Score: 116.51  E-value: 1.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335   8 RPHSPVAKLAVSFLAALAVATAGLYAGQWVPA-------GMYLPLYGLELILLLVMIFARSKK--AVGYPLMFAFMFVSG 78
Cdd:cd10432    1 GLRSFMKKVYGLMAAGLLLTAVGAYVGASTPAllliagsPLMWVLLIAELALVFGLSFRINKMsvATALPLFFAFAALTG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  79 ATLYPLIGYYLsvigAAAVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIqWFIPFSSVGQMGIAA 158
Cdd:cd10432   81 LTLSPILLVYT----GASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLV-NIFLQSSALQFAISA 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523590335 159 LGILIFLGFTIYDINRLARYGF------TEADIPMIVVNIYLDFINLFVYILRFFA 208
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMYEagggesGYKDAIMGALSLYLDFINLFLFLLRLFG 211
 
Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 8-208 1.64e-32

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 116.51  E-value: 1.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335   8 RPHSPVAKLAVSFLAALAVATAGLYAGQWVPA-------GMYLPLYGLELILLLVMIFARSKK--AVGYPLMFAFMFVSG 78
Cdd:cd10432    1 GLRSFMKKVYGLMAAGLLLTAVGAYVGASTPAllliagsPLMWVLLIAELALVFGLSFRINKMsvATALPLFFAFAALTG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  79 ATLYPLIGYYLsvigAAAVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIqWFIPFSSVGQMGIAA 158
Cdd:cd10432   81 LTLSPILLVYT----GASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLV-NIFLQSSALQFAISA 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523590335 159 LGILIFLGFTIYDINRLARYGF------TEADIPMIVVNIYLDFINLFVYILRFFA 208
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMYEagggesGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 16-211 1.81e-30

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 111.81  E-value: 1.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  16 LAVSFLAALAVATAGLYAGQWVPAGMYLPLYGLELILLLVMIF-------ARSKKAVGYPLMFAFMFVSGATLYPLIGYY 88
Cdd:COG0670   30 LALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVfllsklaNRANSAAALALLFAYTALMGLTLSPILLVY 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  89 LSVIGAAAVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPfSSVGQMGIAALGILIFLGFT 168
Cdd:COG0670  110 TGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQ-SPALSLAISVAGVLLFSGLT 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 523590335 169 IYDINRLARYGFTEADIPMIVVNIYLDFINLFVYILRFFASDE 211
Cdd:COG0670  189 LYDTQRIKHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 17-207 9.61e-22

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 88.39  E-value: 9.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335   17 AVSFLAALAVATAGLYAGQWVPAGMYLPLYGLELILLLVMIFARSKKAVGYPLMFAFMFVSGATLYPLIGYYLSVIgaaa 96
Cdd:pfam01027  20 AVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLMGLTLGPLLLVYTGAI---- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335   97 VFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPfSSVGQMGIAALGILIFLGFTIYDINRLA 176
Cdd:pfam01027  96 IATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISYLGVLLFSGFILYDTQRII 174

                         170       180       190
                  ....*....|....*....|....*....|...
gi 523590335  177 RYGFTEADIPMIV--VNIYLDFINLFVYILRFF 207
Cdd:pfam01027 175 KRYGEYGDYDAILaaLSLYLDFINLFLSLLRIL 207
 
Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 8-208 1.64e-32

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 116.51  E-value: 1.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335   8 RPHSPVAKLAVSFLAALAVATAGLYAGQWVPA-------GMYLPLYGLELILLLVMIFARSKK--AVGYPLMFAFMFVSG 78
Cdd:cd10432    1 GLRSFMKKVYGLMAAGLLLTAVGAYVGASTPAllliagsPLMWVLLIAELALVFGLSFRINKMsvATALPLFFAFAALTG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  79 ATLYPLIGYYLsvigAAAVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIqWFIPFSSVGQMGIAA 158
Cdd:cd10432   81 LTLSPILLVYT----GASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLV-NIFLQSSALQFAISA 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523590335 159 LGILIFLGFTIYDINRLARYGF------TEADIPMIVVNIYLDFINLFVYILRFFA 208
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMYEagggesGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 16-211 1.81e-30

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 111.81  E-value: 1.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  16 LAVSFLAALAVATAGLYAGQWVPAGMYLPLYGLELILLLVMIF-------ARSKKAVGYPLMFAFMFVSGATLYPLIGYY 88
Cdd:COG0670   30 LALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVfllsklaNRANSAAALALLFAYTALMGLTLSPILLVY 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  89 LSVIGAAAVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPfSSVGQMGIAALGILIFLGFT 168
Cdd:COG0670  110 TGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQ-SPALSLAISVAGVLLFSGLT 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 523590335 169 IYDINRLARYGFTEADIPMIVVNIYLDFINLFVYILRFFASDE 211
Cdd:COG0670  189 LYDTQRIKHGYETNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 17-207 9.61e-22

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 88.39  E-value: 9.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335   17 AVSFLAALAVATAGLYAGQWVPAGMYLPLYGLELILLLVMIFARSKKAVGYPLMFAFMFVSGATLYPLIGYYLSVIgaaa 96
Cdd:pfam01027  20 AVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLMGLTLGPLLLVYTGAI---- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335   97 VFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPfSSVGQMGIAALGILIFLGFTIYDINRLA 176
Cdd:pfam01027  96 IATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISYLGVLLFSGFILYDTQRII 174

                         170       180       190
                  ....*....|....*....|....*....|...
gi 523590335  177 RYGFTEADIPMIV--VNIYLDFINLFVYILRFF 207
Cdd:pfam01027 175 KRYGEYGDYDAILaaLSLYLDFINLFLSLLRIL 207
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 20-207 4.88e-17

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 75.70  E-value: 4.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  20 FLAALAVATAGLYAGQWVPAGMYLPLYGLELILLLVMIFARSKKA---VGYPLMFAFMFVSGATLYPLIGYYLSVI-GAA 95
Cdd:cd10433   12 MLLSMTLAFSALGAGVSMAGGSPIMGLLLTLVGAYGLLFLIEKTRnsaWGIVLVFAFTGFMGYTLGPILNMYLALPnGGQ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  96 AVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPFSSVgQMGIAALGILIFLGFTIYDINRL 175
Cdd:cd10433   92 IIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPAL-SLAISAAFVLFSSGFILYDTSRI 170

                        170       180       190
                 ....*....|....*....|....*....|..
gi 523590335 176 ARYGftEADIPMIVVNIYLDFINLFVYILRFF 207
Cdd:cd10433  171 IHGG--ETNYIMATVSLYVSIYNLFVSLLNLL 200
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 56-209 6.52e-14

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 68.01  E-value: 6.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  56 MIFARSKKAVGYPLMFAFMFVSGATLYPLIGYYLSVIgaaaVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFA 135
Cdd:cd10429   83 LYWKRHSHPVNLILLSLFTLCEAYTVGLVVSFYDGKI----VLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWA 158

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523590335 136 LLGLLIIQWFIPFSSVGQMGIAALGILIFLGFTIYDINRLARYGFTEADIpMIVVNIYLDFINLFVYILRFFAS 209
Cdd:cd10429  159 LILLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDEYI-LAAISLYLDIINLFLSILRILAA 231
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 16-208 1.27e-10

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 58.58  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  16 LAVSFLAALAVATAGLYA-GQWVPAGMYLPLYGLELILLLVMIFARSKKAVGYPLMFAFMFVSGATLYPLIGYYLSVIga 94
Cdd:cd06181   13 LALQLLLTAATATAFTVCdPGWYWSPALMGLLTSMLALMATAAMIRAKMPVNLILLFGFTGLMGYVVGPLLFFYGPTI-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  95 aaVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIpFSSVGQMGIAALGILIFLGFTIYDINR 174
Cdd:cd06181   91 --LLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFF-YSPWLHLVAAAVGLVLFCGFLLYDTQL 167

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 523590335 175 L-ARYGFTEADIPMIVVNIYLDFINLFVYILRFFA 208
Cdd:cd06181  168 IiHKAEVGPEDYINACISLYLDIINIFIRLLTILA 202
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 19-212 7.42e-09

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 53.77  E-value: 7.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  19 SFLAALAVATAGLYAGQWVPAGMYLPLYGLELILLLVMIFARSKKAVG--YPLMFAFMFVSGATLYPLIGYYLSvIGAAA 96
Cdd:cd10430   18 TLAVALLAAAVGAYVHMVINIGGLLTGLLSLGLSLWLAFTPSTGKNEPkrLGLLLGFAFLTGASLGPLLDLVIA-INPSI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  97 VFKAF---ALAVVSFSGVAIYAARTKedFSFLGGFLMLGAFALLGLLIIQWFIPFSSVGQMGIaALGILIFLGFTIYD-- 171
Cdd:cd10430   97 IVTAFlgtAVIFACFSLAALLAKRRE--YLYLGGLLSSALSILLLVSLANIFGGSKFLFQAEL-YLGLLVFCGFVLFDtq 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 523590335 172 -INRLARYGftEADIPMIVVNIYLDFINLFVYILRFFASDED 212
Cdd:cd10430  174 mIIEKAENG--DRDYIWHALDLFVDFVALFRRLLIILAKKEK 213
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 96-208 4.00e-06

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 46.00  E-value: 4.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  96 AVFKAFALAVVSFSGVAIYAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPfSSVGQMGIAALGILIFLGFTIYDINRL 175
Cdd:cd10428  103 AVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFY-VKWLHIVYASLGALLFSLYLAVDTQLL 181

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 523590335 176 A---RYGFTEADIPMIVVNIYLDFINLFVYILRFFA 208
Cdd:cd10428  182 MggrKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 16-209 1.93e-03

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 38.13  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  16 LAVSFLAALAVATAG-----LYAGQWVPAGMYLPLYGLELILLLVMIFARSKkAVGYPLMFAFMFVSGATLYPLIGYYLS 90
Cdd:cd10431   55 LGLTALAAVALSRSPalmrlMAAGPWLAIGATLAAMIGSGMLVRSYTYPENP-GAKHLAWLGHSGVQGAVLAPLCFLGGP 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523590335  91 VIGAAAVFKAFALAVVSFSGvaiyAARTKEDFSFLGGFLMLGAFALLGLLIIQWFIPFSSVGQMGIAAL----GILIFLG 166
Cdd:cd10431  134 LLIRAALYTAGIVGGLSTVA----ACAPSEKFLYMGGPLAIGLGVVFASSLGSMFLPPTTALGAGLYSVslygGLVLFGG 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 523590335 167 FTIYDINRLAR-------YGFTEADIPMIVVNIYLDFINLFVYILRFFAS 209
Cdd:cd10431  210 FLLYDTQKIIKraethplYGVRKYDPINASMSIYMDTINIFIRLVTILAG 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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