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Conserved domains on  [gi|523682689|ref|WP_020804880|]
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MULTISPECIES: HNH endonuclease [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
136-240 6.10e-49

Predicted restriction endonuclease, HNH family [Defense mechanisms];


:

Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 156.70  E-value: 6.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523682689 136 SYIEGATKSITINAYERDPAARRACIAYHGAVCQCCGFDFEKTWGEHGKGFIHVHHIRPLRTLGpDYQIDPVNELVPLCP 215
Cdd:COG3183    7 GFTEGAKKEVTHKRYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLSEIG-EGGVDPIEDLVPLCP 85

                         90       100
                 ....*....|....*....|....*
gi 523682689 216 NCHAMIHRGNeaKPLSVEELRAMMR 240
Cdd:COG3183   86 NCHRMLHRGR--PPLSIEELKKLLK 108
 
Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
136-240 6.10e-49

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 156.70  E-value: 6.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523682689 136 SYIEGATKSITINAYERDPAARRACIAYHGAVCQCCGFDFEKTWGEHGKGFIHVHHIRPLRTLGpDYQIDPVNELVPLCP 215
Cdd:COG3183    7 GFTEGAKKEVTHKRYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLSEIG-EGGVDPIEDLVPLCP 85

                         90       100
                 ....*....|....*....|....*
gi 523682689 216 NCHAMIHRGNeaKPLSVEELRAMMR 240
Cdd:COG3183   86 NCHRMLHRGR--PPLSIEELKKLLK 108
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 164-222 2.79e-08

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 2.79e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 523682689 164 HGAVCQCCGFDFektwgehGKGFIHVHHIRPLRTLGPDyqiDPVNeLVPLCPNCHAMIH 222
Cdd:cd00085   10 RDGLCPYCGKPG-------GTEGLEVDHIIPLSDGGNN---DLDN-LVLLCRKCHRKKH 57
HNHc smart00507
HNH nucleases;
165-218 9.78e-07

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 44.76  E-value: 9.78e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 523682689   165 GAVCQCCGFDFEKTWgehgkgfiHVHHIRPLRTLGPDyqiDPVNeLVPLCPNCH 218
Cdd:smart00507  10 DGVCAYCGKPASEGL--------EVDHIIPLSDGGND---DLDN-LVLLCPKCH 51
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 168-224 1.02e-06

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 44.65  E-value: 1.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 523682689  168 CQCCGFDFektwgeHGKGFIHVHHIRPLRTLGPDyqiDPVNeLVPLCPNCHAMIHRG 224
Cdd:pfam01844   1 CQYCGRPF------HISDALTVDHIIPLSDGGAD---DIEN-LILLCPSCHNKKHNR 47
 
Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
136-240 6.10e-49

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 156.70  E-value: 6.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523682689 136 SYIEGATKSITINAYERDPAARRACIAYHGAVCQCCGFDFEKTWGEHGKGFIHVHHIRPLRTLGpDYQIDPVNELVPLCP 215
Cdd:COG3183    7 GFTEGAKKEVTHKRYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLSEIG-EGGVDPIEDLVPLCP 85

                         90       100
                 ....*....|....*....|....*
gi 523682689 216 NCHAMIHRGNeaKPLSVEELRAMMR 240
Cdd:COG3183   86 NCHRMLHRGR--PPLSIEELKKLLK 108
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 164-222 2.79e-08

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 2.79e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 523682689 164 HGAVCQCCGFDFektwgehGKGFIHVHHIRPLRTLGPDyqiDPVNeLVPLCPNCHAMIH 222
Cdd:cd00085   10 RDGLCPYCGKPG-------GTEGLEVDHIIPLSDGGNN---DLDN-LVLLCRKCHRKKH 57
HNHc smart00507
HNH nucleases;
165-218 9.78e-07

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 44.76  E-value: 9.78e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 523682689   165 GAVCQCCGFDFEKTWgehgkgfiHVHHIRPLRTLGPDyqiDPVNeLVPLCPNCH 218
Cdd:smart00507  10 DGVCAYCGKPASEGL--------EVDHIIPLSDGGND---DLDN-LVLLCPKCH 51
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 168-224 1.02e-06

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 44.65  E-value: 1.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 523682689  168 CQCCGFDFektwgeHGKGFIHVHHIRPLRTLGPDyqiDPVNeLVPLCPNCHAMIHRG 224
Cdd:pfam01844   1 CQYCGRPF------HISDALTVDHIIPLSDGGAD---DIEN-LILLCPSCHNKKHNR 47
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
150-218 6.27e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 39.97  E-value: 6.27e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523682689 150 YERDPAARRACIAYHGAVCQCCGFDFEKTwgehgkgFIHVHHIRPLRTLGPDyqiDPVNeLVPLCPNCH 218
Cdd:COG1403    4 GREWPALRRAVLKRDNGRCQYCGRPFSGD-------ALEVDHIIPRSRGGTD---TWEN-LVLLCRRCN 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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