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Conserved domains on  [gi|523687744|ref|WP_020806835|]
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MULTISPECIES: amino acid ABC transporter permease [Lactobacillus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 10-216 2.31e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 226.49  E-value: 2.31e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  10 WINIRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPT 89
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  90 VASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVL 169
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 523687744 170 PELLFHAQIIYSQNTTYlIPMYVIIAIMYFIVCFSLSMIAKHLQSKY 216
Cdd:COG0765  169 PELTRAAQQIASRTFRP-FEVYLVAALIYLVLTLPLSLLARRLERRL 214
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 10-216 2.31e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 226.49  E-value: 2.31e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  10 WINIRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPT 89
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  90 VASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVL 169
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 523687744 170 PELLFHAQIIYSQNTTYlIPMYVIIAIMYFIVCFSLSMIAKHLQSKY 216
Cdd:COG0765  169 PELTRAAQQIASRTFRP-FEVYLVAALIYLVLTLPLSLLARRLERRL 214
PRK15100 PRK15100
cystine ABC transporter permease;
15-215 7.30e-43

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 143.74  E-value: 7.30e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  15 FLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPTVASII 94
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  95 ALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLF 174
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 523687744 175 HAQIIYSQnTTYLIPMYVIIAIMYFIVCFSLSMIAKHLQSK 215
Cdd:PRK15100 174 QAQLITSR-TLEVFTMYLAASLIYWIMATVLSALQNRFENQ 213
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 16-216 5.07e-32

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 115.72  E-value: 5.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   16 LLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPTVASIIA 95
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPALVAGVLG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   96 LVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLFH 175
Cdd:TIGR03003  93 LGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMNQ 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 523687744  176 AQIIYSQNTTYLIPMyVIIAIMYFIVCFSLSMIAKHLQSKY 216
Cdd:TIGR03003 173 AKSIGNSTFRYLEPM-TLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 20-203 1.42e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 69.23  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  20 LWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELG---IVTNPTVASIIAL 96
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  97 VVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLFHA 176
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*..
gi 523687744 177 QIIYSQNTTYLIPMYVIIAIMYFIVCF 203
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLL 187
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-215 1.27e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 52.69  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   34 SFILGLVCGFIRYvkiKYLSTIVGFVIDIIRNLPLLLIIFFTYFgLPELGIVTNPTVASIIALVVFEGAMLAEIVRSGIA 113
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  114 AVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLFH--AQIIYSQNTTYLIPMY 191
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLllIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....
gi 523687744  192 VIIAIMYFIVCFSLSMIAKHLQSK 215
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPR 180
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 10-216 2.31e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 226.49  E-value: 2.31e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  10 WINIRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPT 89
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  90 VASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVL 169
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 523687744 170 PELLFHAQIIYSQNTTYlIPMYVIIAIMYFIVCFSLSMIAKHLQSKY 216
Cdd:COG0765  169 PELTRAAQQIASRTFRP-FEVYLVAALIYLVLTLPLSLLARRLERRL 214
PRK15100 PRK15100
cystine ABC transporter permease;
15-215 7.30e-43

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 143.74  E-value: 7.30e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  15 FLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPTVASII 94
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  95 ALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLF 174
Cdd:PRK15100  94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 523687744 175 HAQIIYSQnTTYLIPMYVIIAIMYFIVCFSLSMIAKHLQSK 215
Cdd:PRK15100 174 QAQLITSR-TLEVFTMYLAASLIYWIMATVLSALQNRFENQ 213
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 16-216 5.07e-32

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 115.72  E-value: 5.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   16 LLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPTVASIIA 95
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPALVAGVLG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   96 LVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLFH 175
Cdd:TIGR03003  93 LGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMNQ 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 523687744  176 AQIIYSQNTTYLIPMyVIIAIMYFIVCFSLSMIAKHLQSKY 216
Cdd:TIGR03003 173 AKSIGNSTFRYLEPM-TLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 3-215 3.80e-25

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 97.82  E-value: 3.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   3 NFIHAYSWINIRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPEL 82
Cdd:PRK09494   2 QFDWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  83 --GIVTNPTVASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKD 160
Cdd:PRK09494  82 fnDLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKD 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 523687744 161 TSLATIIVLPELLFHAQIIYSQNTTYLiPMYVIIAIMYFIVCFSLSMIAKHLQSK 215
Cdd:PRK09494 162 TSLFIVIGVAELTRQGQEIIAGNFRAL-EIWSAVAVIYLIITLVLSFILRRLERR 215
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 12-110 1.15e-24

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 92.98  E-value: 1.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   12 NIRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPTVA 91
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTA 80

                          90
                  ....*....|....*....
gi 523687744   92 SIIALVVFEGAMLAEIVRS 110
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIFRG 99
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
12-215 1.20e-23

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 94.13  E-value: 1.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  12 NIRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPE-----LGIVT 86
Cdd:PRK15107  12 SLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGflqnvLGLSP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  87 NPTVASIIALV---VFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSL 163
Cdd:PRK15107  92 KTDIRLISAMVafsMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSL 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 523687744 164 ATIIVLPELLFHAQIIYSQNTTYlIPMYVIIAIMYFIVCFSLSMIAKHLQSK 215
Cdd:PRK15107 172 VYVLSLADFFRTASTIGERDGTQ-VEMILFAGFVYFVISLSASLLVSYLKKR 222
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 19-172 5.67e-22

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 92.13  E-value: 5.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  19 GLWVTIYVSLISIALSFILGlvcgfiRYVKIKYLST-----IVGFVIDIIRNLPLLLIIFF---TYFGLPELG------- 83
Cdd:COG4597  185 GFGWVLAALLAAIVAAFVLR------RWARRRQEATgqrfpVWWISLALLVGLPLLAFLLLgapLSLDYPELKgfnfrgg 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  84 -IVTNPTVASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTS 162
Cdd:COG4597  259 lTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSS 338

                        170
                 ....*....|
gi 523687744 163 LATIIVLPEL 172
Cdd:COG4597  339 LAVAIGYPDL 348
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 20-203 1.42e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 69.23  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  20 LWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELG---IVTNPTVASIIAL 96
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  97 VVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLFHA 176
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|....*..
gi 523687744 177 QIIYSQNTTYLIPMYVIIAIMYFIVCF 203
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLL 187
artM PRK11122
arginine ABC transporter permease ArtM;
16-201 1.66e-14

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 69.60  E-value: 1.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  16 LLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFG---------LPEL-GIV 85
Cdd:PRK11122   8 LLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqfpwlqeYPWLwHLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  86 TNPTVASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMyHVIIPQALNKMIPSLLSQFVSLVKDTSLAT 165
Cdd:PRK11122  88 SQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLVFKSTSLAY 166

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 523687744 166 IIVLPELLFHAQIIYSQntTYLIPMYVIIAIMYFIV 201
Cdd:PRK11122 167 TITLMDVMGYSQLLYGR--TYDVMVFGAAGIIYLVV 200
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
16-201 2.32e-13

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 66.62  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  16 LLQGLWVTIYVSLISIALSFILGL---VCGFIRYVKIKYLSTivGFVIdIIRNLPLLLIIFFTYFGLPEL------GIVT 86
Cdd:PRK11123   7 LASAAGMTVGLAVCALIVGLALAMlfaVWESAKWRPVAWPGT--ALVT-LLRGLPEILVVLFIYFGSSQLlltlsdGFTL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  87 N------------------PTVASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIP 148
Cdd:PRK11123  84 NlgfvqipvqmdienfevsPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALP 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 523687744 149 SLLSQFVSLVKDTSLATIIVLPELLFHAQIIySQNTTYLIPMYVIIAIMYFIV 201
Cdd:PRK11123 164 GLGNQWLVLLKDTALVSLISVNDLMLQTKSI-ATRTQEPFTWYIIAAAIYLVI 215
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 9-153 1.11e-12

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 64.72  E-value: 1.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   9 SWINIRFLLQGLWVTIYVSLISIALSFILGLVCGFI---RYVKIKYLSTIVGFVIDIIRNLPLLL--IIFFTYFGLPELg 83
Cdd:COG3639   42 DWSYLPDLLSALLETLAIALLGTLLGAVLALPLAFLaarNLAPNPWVRLLARRLLNVLRAIPELVwaLIFVAAVGLGPF- 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  84 ivtnptvASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALnkmiPSLLSQ 153
Cdd:COG3639  121 -------AGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVL----PQFLSY 179
PRK15069 PRK15069
histidine ABC transporter permease HisM;
17-205 3.70e-11

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 60.45  E-value: 3.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  17 LQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLPELGIVTNPTV------ 90
Cdd:PRK15069  20 FTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVRGTDLldaffr 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  91 ----ASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATI 166
Cdd:PRK15069 100 sglnCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFT 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 523687744 167 IVLPELLFHAQIIYSqnTTYL-IPMYVIIAIMYFIVCFSL 205
Cdd:PRK15069 180 ATVPDILKIARDINS--ATYQpFQAFGIAAVLYLIISFVL 217
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 9-153 4.70e-10

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 57.55  E-value: 4.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744    9 SWINIRFLLQGLWVTIYVSLISIALSFILGLVCGFI---RYVKIKYLSTIVGFVIDIIRNLPLLL--IIFFTYFGLPelg 83
Cdd:TIGR01097  49 DWSYLPRILKALLETLAMAILGTVLAAVLAVPLALLaarNITPSPWLYGLARLLLNFLRAIPELVwaLIFVAAVGLG--- 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   84 ivtnpTVASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALnkmiPSLLSQ 153
Cdd:TIGR01097 126 -----PFAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVL----PQFLSY 186
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-215 1.27e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 52.69  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   34 SFILGLVCGFIRYvkiKYLSTIVGFVIDIIRNLPLLLIIFFTYFgLPELGIVTNPTVASIIALVVFEGAMLAEIVRSGIA 113
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  114 AVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLATIIVLPELLFH--AQIIYSQNTTYLIPMY 191
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLllIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....
gi 523687744  192 VIIAIMYFIVCFSLSMIAKHLQSK 215
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPR 180
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
16-178 1.43e-08

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 53.26  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  16 LLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLPLLLIIFFTYFGLP-ELGIVT-------- 86
Cdd:PRK15135   9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQiALNSVTealgvgqi 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  87 --NPTVASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSLA 164
Cdd:PRK15135  89 diDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALV 168

                        170
                 ....*....|....
gi 523687744 165 TIIVLPELLFHAQI 178
Cdd:PRK15135 169 SLLGLEDVVKATQL 182
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 16-143 4.43e-08

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 51.69  E-value: 4.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  16 LLQGLWVTIYVSLISIALSFILGLVCGFIrYVKIKYLSTIVGFVIDIIRNLPL--LLIIFFTYFGLPELGIVTnptvasI 93
Cdd:COG0600   59 LWEHLLASLLRVLLGFALAALLGVPLGLL-LGLSRLLRRLLDPLLVFLRPIPPlaLAPLLILWFGIGEASKIF------V 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 523687744  94 IALVVFegAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQAL 143
Cdd:COG0600  132 IFLGAF--FPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAAL 179
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
13-158 1.66e-05

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 43.95  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  13 IRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYV-------KIKYLSTIVGFVIDIIRNLPLLLIIFFTyfgLPELGIV 85
Cdd:PRK10782   6 MWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVtrpgqiiANAKLYRTLSALVNIFRSIPFIILLVWM---IPFTRVI 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523687744  86 TNPTV---ASIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLV 158
Cdd:PRK10782  83 VGTSIglqAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLV 158
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
 1-166 3.90e-05

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 43.12  E-value: 3.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744   1 MENFIHAYSWINIRFLLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFViDIIRNLP-LLLIIFFtyfgL 79
Cdd:COG1174    1 MNLSLIEWLADNRDGILALLLEHLLLVLLALLIALLIAVPLGILITRRRRLAGLVLGVA-NILQTIPsLALLALL----I 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  80 PELGIVTNPTvasIIALVVFegAMLAeIVRS---GIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALnkmiPSLLSQF-V 155
Cdd:COG1174   76 PLLGIGPAPA---IIALVLY--ALLP-ILRNtytGLRSVDPAVVEAARGMGMTPWQRLWRVELPLAL----PVILAGIrT 145

                        170
                 ....*....|.
gi 523687744 156 SLVKDTSLATI 166
Cdd:COG1174  146 AAVQNIGTATL 156
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 16-152 1.99e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 38.17  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  16 LLQGLWVTIYVSLISIALSFILGLVCGF-IRYVKIKYLSTIVGFVIdiirnLPLL---------LIIFFTYFGLPeLGIV 85
Cdd:COG1177   59 LLDALLNSLLIALLSTLLATVLGTPAALaLARYRFRGRRLLLALLL-----LPLVvpgivlgvaLLLLFSALGLS-GGLW 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523687744  86 TnptvaSIIALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALnkmiPSLLS 152
Cdd:COG1177  133 G-----LILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA----PGILA 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
16-170 5.70e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 37.06  E-value: 5.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523687744  16 LLQGLWVTIYVSLISIALSFILGLVCGFIRYVKIKYLSTIVGFVIDIIRNLP--LLLIIFFTYFGLPELGIVTNPTVASI 93
Cdd:COG1178  336 LLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPgiVLGLGLLLLFNRPLPLLLYGTLAILV 415

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523687744  94 IALVVFEGAMLAEIVRSGIAAVDPGQMEGARSNGMTYMQAMYHVIIPQALNKMIPSLLSQFVSLVKDTSlATIIVLP 170
Cdd:COG1178  416 LAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELS-ATLLLRP 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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