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Conserved domains on  [gi|523688515|ref|WP_020807593|]
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MULTISPECIES: Rpn family recombination-promoting nuclease/putative transposase [Lactobacillus]

Protein Classification

Rpn family recombination-promoting nuclease/putative transposase( domain architecture ID 11493162)

Rpn family recombination-promoting nuclease/putative transposase belonging to the PD-(D/E)XK nuclease superfamily is associated with transposition, inversion, or recombination

EC:  3.1.21.-
Gene Ontology:  GO:0006310|GO:0004536|GO:0003677|GO:0032196|GO:0015074|GO:0004803
PubMed:  28096446|20215432|11774877|15972856

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T_den_put_tspse TIGR01784
conserved hypothetical protein (putative transposase or invertase); Several lines of evidence ...
 2-250 5.01e-62

conserved hypothetical protein (putative transposase or invertase); Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.


:

Pssm-ID: 273806 [Multi-domain]  Cd Length: 270  Bit Score: 195.69  E-value: 5.01e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515    2 EQGTNCRDLLQAIAPEL-HIQTASFETQKRLKFHPAMHSIIPDIYATDDKGRVFDIELQMTLPDFLGKRMRYYFSMMDQS 80
Cdd:TIGR01784  13 ENEDFLIIFLNAVLGELlDIKTLELSSQSFVEENLEDKFSDLDILATDSEGLHYNIEHQVAPDKDMAKRMLYYWSAMYQS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515   81 LFMQGENYRNLPTTYLILILPTDPLGLDQYRYDTTWNTKGFKHDPLNIGQKLILLNASGTKGKITPRLQG----FFDLMR 156
Cdd:TIGR01784  93 QLKQGDKYVVLAPTVFINILPFDLFGDEERVHNIYLSEEEDSIFELTDLQELHLLELPKLKAIIDERLLDvldrWLLLLK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515  157 GKIN--TNDSFIQK--LQSDVEKYKTNPERRKELMDYQMKLDDMRYV--GEKNGKEEERIDAIKKMINLSRKLNASNDFI 230
Cdd:TIGR01784 173 GKDNqsVNLIFLQIpfIQKAEEEIKTLLLSSKELELYEQREKYMTDAisAEEEGKEEGIEEGILEAKLETAKKLLKNGLT 252

                         250       260
                  ....*....|....*....|
gi 523688515  231 LKQLTDDYGayFSQEELKQF 250
Cdd:TIGR01784 253 LEQVAEATG--LSVEELEEI 270
 
Name Accession Description Interval E-value
T_den_put_tspse TIGR01784
conserved hypothetical protein (putative transposase or invertase); Several lines of evidence ...
 2-250 5.01e-62

conserved hypothetical protein (putative transposase or invertase); Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.


Pssm-ID: 273806 [Multi-domain]  Cd Length: 270  Bit Score: 195.69  E-value: 5.01e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515    2 EQGTNCRDLLQAIAPEL-HIQTASFETQKRLKFHPAMHSIIPDIYATDDKGRVFDIELQMTLPDFLGKRMRYYFSMMDQS 80
Cdd:TIGR01784  13 ENEDFLIIFLNAVLGELlDIKTLELSSQSFVEENLEDKFSDLDILATDSEGLHYNIEHQVAPDKDMAKRMLYYWSAMYQS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515   81 LFMQGENYRNLPTTYLILILPTDPLGLDQYRYDTTWNTKGFKHDPLNIGQKLILLNASGTKGKITPRLQG----FFDLMR 156
Cdd:TIGR01784  93 QLKQGDKYVVLAPTVFINILPFDLFGDEERVHNIYLSEEEDSIFELTDLQELHLLELPKLKAIIDERLLDvldrWLLLLK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515  157 GKIN--TNDSFIQK--LQSDVEKYKTNPERRKELMDYQMKLDDMRYV--GEKNGKEEERIDAIKKMINLSRKLNASNDFI 230
Cdd:TIGR01784 173 GKDNqsVNLIFLQIpfIQKAEEEIKTLLLSSKELELYEQREKYMTDAisAEEEGKEEGIEEGILEAKLETAKKLLKNGLT 252

                         250       260
                  ....*....|....*....|
gi 523688515  231 LKQLTDDYGayFSQEELKQF 250
Cdd:TIGR01784 253 LEQVAEATG--LSVEELEEI 270
PDDEXK_2 pfam12784
PD-(D/E)XK nuclease family transposase; Members of this family belong to the PD-(D/E)XK ...
 43-100 2.28e-06

PD-(D/E)XK nuclease family transposase; Members of this family belong to the PD-(D/E)XK nuclease superfamily. These proteins are transposase proteins.


Pssm-ID: 432783  Cd Length: 228  Bit Score: 47.27  E-value: 2.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 523688515   43 DIYATDDKGRVFDIELQMTLPDFLGKRMRYYFSMMDQSLFMQGENYRNLPTTYLILIL 100
Cdd:pfam12784  57 DIKCKTENGEIINIEMQKSWQYNFKERSLYYWSRLYSEQLKKGQEYKELKKVYTINIL 114
 
Name Accession Description Interval E-value
T_den_put_tspse TIGR01784
conserved hypothetical protein (putative transposase or invertase); Several lines of evidence ...
 2-250 5.01e-62

conserved hypothetical protein (putative transposase or invertase); Several lines of evidence suggest that members of this family (loaded as a fragment mode model to find part-length matches) are associated with transposition, inversion, or recombination. Members are found in small numbers of genomes, but in large copy numbers in many of those species, including over 30 full length and fragmentary members in Treponema denticola. The strongest similarities are usually within rather than between species. PSI-BLAST shows similarity to proteins designated as possible transposases, DNA invertases (resolvases), and recombinases. In the oral pathogenic spirochete Treponema denticola, full-length members are often found near transporters or other membrane proteins. This family includes members of the putative transposase family pfam04754.


Pssm-ID: 273806 [Multi-domain]  Cd Length: 270  Bit Score: 195.69  E-value: 5.01e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515    2 EQGTNCRDLLQAIAPEL-HIQTASFETQKRLKFHPAMHSIIPDIYATDDKGRVFDIELQMTLPDFLGKRMRYYFSMMDQS 80
Cdd:TIGR01784  13 ENEDFLIIFLNAVLGELlDIKTLELSSQSFVEENLEDKFSDLDILATDSEGLHYNIEHQVAPDKDMAKRMLYYWSAMYQS 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515   81 LFMQGENYRNLPTTYLILILPTDPLGLDQYRYDTTWNTKGFKHDPLNIGQKLILLNASGTKGKITPRLQG----FFDLMR 156
Cdd:TIGR01784  93 QLKQGDKYVVLAPTVFINILPFDLFGDEERVHNIYLSEEEDSIFELTDLQELHLLELPKLKAIIDERLLDvldrWLLLLK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523688515  157 GKIN--TNDSFIQK--LQSDVEKYKTNPERRKELMDYQMKLDDMRYV--GEKNGKEEERIDAIKKMINLSRKLNASNDFI 230
Cdd:TIGR01784 173 GKDNqsVNLIFLQIpfIQKAEEEIKTLLLSSKELELYEQREKYMTDAisAEEEGKEEGIEEGILEAKLETAKKLLKNGLT 252

                         250       260
                  ....*....|....*....|
gi 523688515  231 LKQLTDDYGayFSQEELKQF 250
Cdd:TIGR01784 253 LEQVAEATG--LSVEELEEI 270
PDDEXK_2 pfam12784
PD-(D/E)XK nuclease family transposase; Members of this family belong to the PD-(D/E)XK ...
 43-100 2.28e-06

PD-(D/E)XK nuclease family transposase; Members of this family belong to the PD-(D/E)XK nuclease superfamily. These proteins are transposase proteins.


Pssm-ID: 432783  Cd Length: 228  Bit Score: 47.27  E-value: 2.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 523688515   43 DIYATDDKGRVFDIELQMTLPDFLGKRMRYYFSMMDQSLFMQGENYRNLPTTYLILIL 100
Cdd:pfam12784  57 DIKCKTENGEIINIEMQKSWQYNFKERSLYYWSRLYSEQLKKGQEYKELKKVYTINIL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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