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Conserved domains on  [gi|544679838|ref|WP_021112014|]
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nitroreductase family protein [Glaesserella parasuis]

Protein Classification

nitroreductase family protein( domain architecture ID 10114825)

nitroreductase family protein may catalyze the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles, requiring NAD(P)H as an electron donor in an obligatory two-electron transfer and using FMN as cofactor

CATH:  3.40.109.10
EC:  1.7.1.-
Gene Ontology:  GO:0016491
PubMed:  25702712|7601851|29078300
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 5-197 4.67e-46

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


:

Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 149.31  E-value: 4.67e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   5 DVIKQRKTIKMFNNQVQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLdKVTFNAPPCESASAVVVILADL 84
Cdd:cd02137    2 EVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLA-EAAYNQPQVTTASAVILVLGDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  85 hyekllgdvldhsiasgclhqnfrensfnflmgvhntlstqdirdqvliDTSLVAMQLMLVVKEKGYDSHAIGIFDRKAV 164
Cdd:cd02137   81 -------------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKV 111

                        170       180       190
                 ....*....|....*....|....*....|...
gi 544679838 165 LEVLEIDsERYAPVMLLAIGKAAVPALPSVRLP 197
Cdd:cd02137  112 AELLNLP-DRYVPVLLIAIGKAADKAPRSGRLP 143
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 5-197 4.67e-46

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 149.31  E-value: 4.67e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   5 DVIKQRKTIKMFNNQVQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLdKVTFNAPPCESASAVVVILADL 84
Cdd:cd02137    2 EVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLA-EAAYNQPQVTTASAVILVLGDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  85 hyekllgdvldhsiasgclhqnfrensfnflmgvhntlstqdirdqvliDTSLVAMQLMLVVKEKGYDSHAIGIFDRKAV 164
Cdd:cd02137   81 -------------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKV 111

                        170       180       190
                 ....*....|....*....|....*....|...
gi 544679838 165 LEVLEIDsERYAPVMLLAIGKAAVPALPSVRLP 197
Cdd:cd02137  112 AELLNLP-DRYVPVLLIAIGKAADKAPRSGRLP 143
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-202 2.48e-41

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 137.68  E-value: 2.48e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   3 LIDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVT-FNAPPCESASAVVVIL 81
Cdd:COG0778    1 LLELLLTRRSVRKFTDK-PVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAeANQEWVADAPVLIVVC 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  82 ADLHyekllgdvldhsiasgclhqnfrensfnflmgvhntLSTQDIRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIFDR 161
Cdd:COG0778   80 ADPD------------------------------------RSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFDP 123

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 544679838 162 KAVLEVLEIDsERYAPVMLLAIGKAAVPALPSVRLPTEYTV 202
Cdd:COG0778  124 EKVRELLGLP-EGEEPVALLALGYPAEELNPRPRKPLEEVV 163
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-185 4.18e-25

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 96.31  E-value: 4.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838    7 IKQRKTIKMFNNQVqISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVtFNAPPCESASAVVVILADLH- 85
Cdd:pfam00881   1 IRQRRSVRKFDPEP-VPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAA-LELLLVEPAAALLLLLRRDAn 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   86 YEKLLGDVLDHS---IASGCLHQNFRensfnflmgvhnTLSTQDIRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIFDRK 162
Cdd:pfam00881  79 LKLLLQDFLRGApvlIVITASLSTYL------------RKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAA 146

                         170       180
                  ....*....|....*....|...
gi 544679838  163 AVLEVLEIDSErYAPVMLLAIGK 185
Cdd:pfam00881 147 AVRELLGLPDD-ERLVGLIAVGY 168
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
1-199 2.87e-15

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 71.54  E-value: 2.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   1 MQLIDVIKQRKTIKMFNNQVQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVT----FNAPPCESASA 76
Cdd:PRK11053   1 MDIVSVAKKRYTTKAFDPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKAAAgnyaFNERKILDASH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  77 VVVILA--DLHYEKLLgDVLDHSIASGclhqnfRENSFNFLMGVHNT------LSTQDIRD-------QVLIDTSlvamQ 141
Cdd:PRK11053  81 VVVFCAktDMDDAYLE-LVLEQEDADG------RFATEEAKAAQDKGrrffadMHRKELKDlqhwmekQVYLALG----N 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544679838 142 LMLVVKEKGYDSHAIGIFDRKAVLEVLEIDSERYAPVMLLAIGKAAV----PALPSVRLPTE 199
Cdd:PRK11053 150 LLLGAAALGIDATPIEGFDAAILDAEFGLREKGLTSSVVVPLGYHSEedfnAKLPKSRLPQE 211
BluB TIGR02476
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ...
 2-58 1.40e-03

5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 162875  Cd Length: 205  Bit Score: 38.19  E-value: 1.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 544679838    2 QLIDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFV-ILDQAEQKQ 58
Cdd:TIGR02476   8 AVYRLIRERRDVRHFRSD-PVPEAVLERLLDAAHHAPSVGFSQPWRFVrVESPATREA 64
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 5-197 4.67e-46

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 149.31  E-value: 4.67e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   5 DVIKQRKTIKMFNNQVQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLdKVTFNAPPCESASAVVVILADL 84
Cdd:cd02137    2 EVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLA-EAAYNQPQVTTASAVILVLGDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  85 hyekllgdvldhsiasgclhqnfrensfnflmgvhntlstqdirdqvliDTSLVAMQLMLVVKEKGYDSHAIGIFDRKAV 164
Cdd:cd02137   81 -------------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKV 111

                        170       180       190
                 ....*....|....*....|....*....|...
gi 544679838 165 LEVLEIDsERYAPVMLLAIGKAAVPALPSVRLP 197
Cdd:cd02137  112 AELLNLP-DRYVPVLLIAIGKAADKAPRSGRLP 143
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-202 2.48e-41

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 137.68  E-value: 2.48e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   3 LIDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVT-FNAPPCESASAVVVIL 81
Cdd:COG0778    1 LLELLLTRRSVRKFTDK-PVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAeANQEWVADAPVLIVVC 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  82 ADLHyekllgdvldhsiasgclhqnfrensfnflmgvhntLSTQDIRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIFDR 161
Cdd:COG0778   80 ADPD------------------------------------RSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFDP 123

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 544679838 162 KAVLEVLEIDsERYAPVMLLAIGKAAVPALPSVRLPTEYTV 202
Cdd:COG0778  124 EKVRELLGLP-EGEEPVALLALGYPAEELNPRPRKPLEEVV 163
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 2-199 9.09e-29

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 105.41  E-value: 9.09e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   2 QLIDVIKQRKTIKMFNNQVQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVTFNAPPCESASAVVVIL 81
Cdd:cd02149    1 NILELLNFRYATKKFDPNKKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPAAWFNQPQIKDASHVVVFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  82 ADLHYEKLlgdvldhsiasgclhqnfrensfnflmgvhntlstqdirdQVLIdtslvAM-QLMLVVKEKGYDSHAIGIFD 160
Cdd:cd02149   81 AKKDWSAK----------------------------------------QTYI-----ALgNMLLAAAMLGIDSCPIEGFD 115

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 544679838 161 RKAVLEVLEIDSERYAPVMLLAIGKAAVPALPSVRLPTE 199
Cdd:cd02149  116 PAKLDEILGLDEKGYKISVMVAFGYRSEEKLPKSRKPLE 154
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 5-199 1.29e-27

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 103.17  E-value: 1.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   5 DVIKQRKTIKMFNnQVQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLdKVTFNAPPCESASAVVVILADL 84
Cdd:cd03370    3 EAIESRRSIRKYT-QEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQ-AAAYGQAQVTSAPAVIVIYSDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  85 HyekllgDVLDHsiASGCLHQNF----RENSFNFLMGVHNTLSTQDiRDQVLIDTSLVAMQ-LMLVVKEKGYDSHAIGIF 159
Cdd:cd03370   81 E------DALAN--LEETIHPGLseerRQREAAGLRGAFGKMSVEQ-RGQWGLAQANIALGfLLLAAQSLGYDTSPMLGF 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 544679838 160 DRKAVLEVLEIdSERYAPVMLLAIGKAAVPALPSVRLPTE 199
Cdd:cd03370  152 DPEKVKALLGL-PEHVTIAALVALGKPAEEGYPHHRHSLE 190
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-184 1.27e-25

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 96.60  E-value: 1.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   7 IKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVTFNAPPCESASAVVVILADlhy 86
Cdd:cd02062    1 IKTRRSIRKFTDK-PVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNQKFIAGAPVVIVVVAD--- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  87 ekllgdvldhsiasgclhqnfrensfnflmgvhntlsTQDIRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIFDR--KAV 164
Cdd:cd02062   77 -------------------------------------PDKSRPWALEDAGAAAQNLLLAAAALGLGSCWIGGFDFreDKV 119

                        170       180
                 ....*....|....*....|
gi 544679838 165 LEVLEIDsERYAPVMLLAIG 184
Cdd:cd02062  120 RELLGIP-ENLRPVALIAIG 138
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-185 4.18e-25

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 96.31  E-value: 4.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838    7 IKQRKTIKMFNNQVqISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVtFNAPPCESASAVVVILADLH- 85
Cdd:pfam00881   1 IRQRRSVRKFDPEP-VPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAA-LELLLVEPAAALLLLLRRDAn 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   86 YEKLLGDVLDHS---IASGCLHQNFRensfnflmgvhnTLSTQDIRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIFDRK 162
Cdd:pfam00881  79 LKLLLQDFLRGApvlIVITASLSTYL------------RKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAA 146

                         170       180
                  ....*....|....*....|...
gi 544679838  163 AVLEVLEIDSErYAPVMLLAIGK 185
Cdd:pfam00881 147 AVRELLGLPDD-ERLVGLIAVGY 168
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-184 4.63e-19

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 79.74  E-value: 4.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   3 LIDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKlLDKVT---FNAPpcesasAVVV 79
Cdd:cd20609    2 FLELAKKRYSVRKFSDK-PVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEK-LAKATprfFGAP------LVIV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  80 ILAdlhyekllgdvlDHSIAsgclhqNFRENsfnflmgvhntlstqDIRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIF 159
Cdd:cd20609   74 VCY------------DKDES------WKRPY---------------DGKDSGDIDAAIVATHMMLAATELGLGTCWVGNF 120

                        170       180
                 ....*....|....*....|....*
gi 544679838 160 DRKAVLEVLEIDsERYAPVMLLAIG 184
Cdd:cd20609  121 DPEKVREAFNLP-ENLEPVAILPLG 144
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 16-197 6.72e-19

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 79.90  E-value: 6.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  16 FNNQvQISREELTEMIELAQLAPSKANLQPWRFVI-LDQAEQKQKLLDKVT-FNAPPCESASAVVVILADLHYEKllgdv 93
Cdd:cd02138   11 FSPE-PISEEDLLSLFEAARWAPSCFNEQPWRFVVaRRDTEAFEKLLDLLAeGNQSWAKNAPVLIVVLAKTEFDH----- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  94 ldhsiasgclhqnfrensfnflmgvhntlsTQDIRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIFDRKAVLEVLEIDsE 173
Cdd:cd02138   85 ------------------------------NGKPNRYALFDTGAAVANLALQATALGLVVHQMAGFDPEKAKEALGIP-D 133

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 544679838 174 RYAPVMLLAIGKAAVPAL-----------PSVRLP 197
Cdd:cd02138  134 EYEPITMIAIGYPGDPESlpekllereeaPRTRKP 168
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-205 1.94e-16

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 73.27  E-value: 1.94e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   3 LIDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLdKVTFNAPPCESASAVVVILA 82
Cdd:cd02139    1 VYEAIKKRRSIRKYKPT-PVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLA-EAANGQKFIAEAPVVIVACA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  83 DlhyekllgdvLDHSIASgclhqnfrensfnflmgvhntlstqDIRDQVLIDTSLvAMQ-LMLVVKEKGYDSHAIGIFDR 161
Cdd:cd02139   79 D----------PSESGMG-------------------------CGKPYYLVDVAI-AMEhLVLAATEEGLGTCWIGAFDE 122

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 544679838 162 KAVLEVLEIdSERYAPVMLLAIGKAAVPALPSVRLPTEYTVSWN 205
Cdd:cd02139  123 DKVKEILGI-PEEYRVVALTPLGYPAEEPPPRPRKPLEEIVFYE 165
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
1-199 2.87e-15

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 71.54  E-value: 2.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   1 MQLIDVIKQRKTIKMFNNQVQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVT----FNAPPCESASA 76
Cdd:PRK11053   1 MDIVSVAKKRYTTKAFDPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKAAAgnyaFNERKILDASH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  77 VVVILA--DLHYEKLLgDVLDHSIASGclhqnfRENSFNFLMGVHNT------LSTQDIRD-------QVLIDTSlvamQ 141
Cdd:PRK11053  81 VVVFCAktDMDDAYLE-LVLEQEDADG------RFATEEAKAAQDKGrrffadMHRKELKDlqhwmekQVYLALG----N 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544679838 142 LMLVVKEKGYDSHAIGIFDRKAVLEVLEIDSERYAPVMLLAIGKAAV----PALPSVRLPTE 199
Cdd:PRK11053 150 LLLGAAALGIDATPIEGFDAAILDAEFGLREKGLTSSVVVPLGYHSEedfnAKLPKSRLPQE 211
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 5-100 2.80e-13

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 64.86  E-value: 2.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   5 DVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVTFNAPPCESASAVVVILADl 84
Cdd:cd02151    1 ELLKKRRSIRKYTDE-PIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECKPHGSAFLKGAPAAIVVLAD- 78

                         90
                 ....*....|....*...
gi 544679838  85 hyeKLLGDVL--DHSIAS 100
Cdd:cd02151   79 ---TEKSDTWieDASIAA 93
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 5-170 3.28e-13

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 64.28  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   5 DVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVTFNAPPCESASAVVVILADl 84
Cdd:cd20608    2 EAIKTRRSVRRFSDK-PVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSELAKKESPSNGWLKDAPVIIVVCAD- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  85 hyekllgdvldhSIASGCLHQnfrensfnflmgvhntlstqdiRDQVLIDTSLVAMQLMLVVKEKGYDSHAIGIFDRKAV 164
Cdd:cd20608   80 ------------PKDSGWLNG----------------------QNYYLVDAAIAMQNLMLAATDLGLGTCWIGAFDEKKV 125


                 ....*.
gi 544679838 165 LEVLEI 170
Cdd:cd20608  126 KEILGI 131
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 6-202 6.81e-12

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 61.06  E-value: 6.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   6 VIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDqaEQKQKLLDKVTFNAPpcesasaVVVILAdlh 85
Cdd:cd02136    1 AIKSRRSVRAFKDK-PVPKETIEKILEAARRAPSGKNTQPWRVYVVT--GKARERLKKAFFGAP-------VALFLT--- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  86 yekllgdvldhsiasgclhqnfrensfnflmgVHNTLSTQDIrdqvlIDTSLVAMQLMLVVKEKGYDSHAIGIF--DRKA 163
Cdd:cd02136   68 --------------------------------MDKVLGPWSW-----FDLGAFLQNLMLAAHALGLGTCPQGALagYPDV 110

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 544679838 164 VLEVLEIDSErYAPVMLLAIG----KAAVPALPSVRLPTEYTV 202
Cdd:cd02136  111 VRKELGIPDD-EELVCGIALGypdpDAPVNQFRTPREPLEEFV 152
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 7-184 1.32e-11

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 60.31  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   7 IKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDqaeqKQKLLDKVTfNAPP----CESASAVVVILA 82
Cdd:cd02150    1 ILTRRSIRKYTDK-PVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVT----DREKLDKIA-EAHPygkmLKEAPLAIVVCG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  83 DLHYEKllgdvldhsiASGCLHQnfrensfnflmgvhntlstqdirdqvliDTSLVAMQLMLVVKEKGYDSHAIGIF--- 159
Cdd:cd02150   75 DPSKEK----------APGYWVQ----------------------------DCSAATENILLAAHALGLGAVWLGVYpfe 116

                        170       180
                 ....*....|....*....|....*.
gi 544679838 160 DR-KAVLEVLEIDSErYAPVMLLAIG 184
Cdd:cd02150  117 ERvKAIREILNIPEN-IIPFCVIALG 141
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 4-107 6.29e-11

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 58.38  E-value: 6.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   4 IDVIKQRKTIKMFNNQVQISREELTEMIELAQLAPSKANLQPWRFVILdQAEQKQKLLDKV-------TFNAPP--CES- 73
Cdd:cd02135    1 LELIKTRRSIRKFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVV-TGEGRERLAELLaaaaaarAPGADPekLEKa 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 544679838  74 ------ASAVVVILADLHyEKLLGDVLDHSIASGCLHQNF 107
Cdd:cd02135   80 rekalrAPVVIAVVAKPD-EDPKVPEWEQYAAVGAAVQNL 118
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 4-205 8.74e-10

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 56.48  E-value: 8.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838   4 IDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKlLDKVTFNAPPCESASAVVVILAD 83
Cdd:cd02146    2 IETILNHRSVRKFTDE-PLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREK-LAELAGNQPYVAQAPVFLVFCAD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  84 LHYEKLLGDVLDHsiASGCLHqnfreNSFNFLMGVhntlstqdirdqvlIDTSLVAmQLMLVVKEK-GYDSHAIGIF--D 160
Cdd:cd02146   80 LYRHQKIAEEAGG--KDVGLD-----YLESFLVGV--------------VDAALAA-QNALVAAESlGLGIVYIGGIrnN 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 544679838 161 RKAVLEVLEIDSERYaPVMLLAIGKAA-VPAL-PsvRLPTEYTVSWN 205
Cdd:cd02146  138 PEEVIELLGLPEYVF-PLFGLTVGHPDpTPEVkP--RLPLEAVVHEE 181
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 3-59 1.83e-08

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 52.15  E-value: 1.83e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 544679838   3 LIDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQK 59
Cdd:cd02144    1 FYELMKKRRSVRDFSSE-PVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRK 56
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-60 2.63e-08

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 51.51  E-value: 2.63e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 544679838   7 IKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKL 60
Cdd:cd20610    1 IKKRRSIRKFKPD-PVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKI 53
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 22-89 8.33e-08

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 50.58  E-value: 8.33e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  22 ISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVT-FNAPPCESASAVVVILADLH-YEKL 89
Cdd:PRK05365  27 VSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSeGNLAKTLAAPVTAIVAYDTEfHEHL 96
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 22-89 1.58e-07

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 49.56  E-value: 1.58e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544679838  22 ISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKVT-FNAPPCESASAVVVILADLH-YEKL 89
Cdd:cd02148   20 VSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPHLSeGNREKTMAAPVTAILAYDTEfYEHL 89
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 7-64 9.27e-07

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 47.47  E-value: 9.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 544679838   7 IKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLDKV 64
Cdd:cd02143    2 LRSRRSIRRYKDK-PVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLAELV 58
McbC_SagB-like_oxidoreductase cd02142
oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain ...
 131-185 2.33e-04

oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.


Pssm-ID: 380318  Cd Length: 200  Bit Score: 40.48  E-value: 2.33e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 544679838 131 VLIDTSLVAMQLMLVVKEKGYDSHAIGIFDRKAVLEVLEIDSERYAPVMLLAIGK 185
Cdd:cd02142  146 ILLEAGHLAQNLYLAATALGLGLCAIGAFDDDALRELLGLDEVEEVVLYAFVVGG 200
Frm2-like cd02140
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-62 7.48e-04

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380317  Cd Length: 192  Bit Score: 38.83  E-value: 7.48e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544679838   3 LIDVIKQRKTIKMFNNQVQISREELTEMIELA-QLAPSKANLQPWRFVILDQAEQkQKLLD 62
Cdd:cd02140    1 FLEAAKARRTIYALGKNSPVSDEEIEEIVKEAvKHVPSSFNSQSSRAVILLGDEH-KKLWD 60
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 6-62 9.21e-04

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 38.88  E-value: 9.21e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 544679838   6 VIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFVILDQAEQKQKLLD 62
Cdd:cd02145    3 VIRWRRDVRHFRPD-PVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKAVHE 58
BluB TIGR02476
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ...
 2-58 1.40e-03

5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 162875  Cd Length: 205  Bit Score: 38.19  E-value: 1.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 544679838    2 QLIDVIKQRKTIKMFNNQvQISREELTEMIELAQLAPSKANLQPWRFV-ILDQAEQKQ 58
Cdd:TIGR02476   8 AVYRLIRERRDVRHFRSD-PVPEAVLERLLDAAHHAPSVGFSQPWRFVrVESPATREA 64
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 10-55 2.82e-03

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 37.66  E-value: 2.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 544679838   10 RKTIKMFNNQVQI-SREELTEMIELAQLAPSKANLQPWRFVILDQAE 55
Cdd:pfam14512 141 RKPLDELCVVKEDeLPEWFKEGMEAARLAPSAMNQQPWRFVLVDDNR 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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