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Conserved domains on  [gi|544680679|ref|WP_021112793|]
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PACE efflux transporter [Glaesserella parasuis]

Protein Classification

COG4125 family protein( domain architecture ID 11467892)

COG4125 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
1-130 9.98e-42

Uncharacterized membrane protein [Function unknown];


:

Pssm-ID: 443301  Cd Length: 144  Bit Score: 135.35  E-value: 9.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544680679   1 MTFYKHIFHSVLFEIGAIAIGAVAVLLAGDFSLEAAAGTGIAMSVMAMVLNFFFNYVFDKIFTGKRE-ERSLKLRILHTV 79
Cdd:COG4125    2 RSLKERIRHAVLFELIALLISAPLLAWLFGKSLGDMGALAVVLSTIAMLWNYIYNWLFDRWERRQRGvRRTLRVRILHAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 544680679  80 CFECTLLLFTIPVVAYLLNLSLWHAFLADIGLSLLIMLYTLVFNWLYDITR 130
Cdd:COG4125   82 GFEGGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRLF 132
 
Name Accession Description Interval E-value
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
1-130 9.98e-42

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 443301  Cd Length: 144  Bit Score: 135.35  E-value: 9.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544680679   1 MTFYKHIFHSVLFEIGAIAIGAVAVLLAGDFSLEAAAGTGIAMSVMAMVLNFFFNYVFDKIFTGKRE-ERSLKLRILHTV 79
Cdd:COG4125    2 RSLKERIRHAVLFELIALLISAPLLAWLFGKSLGDMGALAVVLSTIAMLWNYIYNWLFDRWERRQRGvRRTLRVRILHAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 544680679  80 CFECTLLLFTIPVVAYLLNLSLWHAFLADIGLSLLIMLYTLVFNWLYDITR 130
Cdd:COG4125   82 GFEGGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRLF 132
PACE_transport NF033664
PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter ...
 2-130 4.60e-32

PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter AceI, average about 140 amino acids in length and consist of two tandem homologous domains described by Pfam model PF05232. PACE transporters are single component efflux transporters that sit in the plasma membrane and couple proton import to substrate export.


Pssm-ID: 411267 [Multi-domain]  Cd Length: 130  Bit Score: 110.34  E-value: 4.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544680679   2 TFYKHIFHSVLFEIGAIAIGAVAVLLAGDFSLEAAAGTGIAMSVMAMVLNFFFNYVFDKIFTGKREERSLKLRILHTVCF 81
Cdd:NF033664   1 GLKERIVHAVLFEVIAILISAPLLAWLMGRSLSHSGALAVMISTIAMLWNMIYNALFERWERRQRVRRRTVRRVLHAIGF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 544680679  82 ECTLLLFTIPVVAYLLNLSLWHAFLADIGLSLLIMLYTLVFNWLYDITR 130
Cdd:NF033664  81 EGGLVLILVPLAAWWLGISLLEAFLLDIGLLLFFLPYTFVFNWAFDKLR 129
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 69-127 1.96e-17

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 70.99  E-value: 1.96e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 544680679   69 RSLKLRILHTVCFECTLLLFTIPVVAYLLNLSLWHAFLADIGLSLLIMLYTLVFNWLYD 127
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFD 59
 
Name Accession Description Interval E-value
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
1-130 9.98e-42

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 443301  Cd Length: 144  Bit Score: 135.35  E-value: 9.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544680679   1 MTFYKHIFHSVLFEIGAIAIGAVAVLLAGDFSLEAAAGTGIAMSVMAMVLNFFFNYVFDKIFTGKRE-ERSLKLRILHTV 79
Cdd:COG4125    2 RSLKERIRHAVLFELIALLISAPLLAWLFGKSLGDMGALAVVLSTIAMLWNYIYNWLFDRWERRQRGvRRTLRVRILHAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 544680679  80 CFECTLLLFTIPVVAYLLNLSLWHAFLADIGLSLLIMLYTLVFNWLYDITR 130
Cdd:COG4125   82 GFEGGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRLF 132
PACE_transport NF033664
PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter ...
 2-130 4.60e-32

PACE efflux transporter; PACE transporters, including the chlorhexidine efflux transporter AceI, average about 140 amino acids in length and consist of two tandem homologous domains described by Pfam model PF05232. PACE transporters are single component efflux transporters that sit in the plasma membrane and couple proton import to substrate export.


Pssm-ID: 411267 [Multi-domain]  Cd Length: 130  Bit Score: 110.34  E-value: 4.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544680679   2 TFYKHIFHSVLFEIGAIAIGAVAVLLAGDFSLEAAAGTGIAMSVMAMVLNFFFNYVFDKIFTGKREERSLKLRILHTVCF 81
Cdd:NF033664   1 GLKERIVHAVLFEVIAILISAPLLAWLMGRSLSHSGALAVMISTIAMLWNMIYNALFERWERRQRVRRRTVRRVLHAIGF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 544680679  82 ECTLLLFTIPVVAYLLNLSLWHAFLADIGLSLLIMLYTLVFNWLYDITR 130
Cdd:NF033664  81 EGGLVLILVPLAAWWLGISLLEAFLLDIGLLLFFLPYTFVFNWAFDKLR 129
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 69-127 1.96e-17

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 70.99  E-value: 1.96e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 544680679   69 RSLKLRILHTVCFECTLLLFTIPVVAYLLNLSLWHAFLADIGLSLLIMLYTLVFNWLYD 127
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFD 59
BTP pfam05232
Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane ...
 1-62 2.29e-10

Chlorhexidine efflux transporter; This family represents a conserved pair of two transmembrane alpha-helices. All members carry the two pairs of TMs. BTP is a form of drug efflux pump, that actively tranports chlorhexidine out of the cell. Chlorhexidine, a bisbiguanide antimicrobial agent, is commonly used as an antiseptic and disinfectant in hospitals, and there is an increasing problem with resistance to it in some pathogenic bacteria. BTP is localized in the cytoplasmic membrane.


Pssm-ID: 428384  Cd Length: 64  Bit Score: 52.89  E-value: 2.29e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544680679    1 MTFYKHIFHSVLFEIGAIAIGAVAVLLAGDFSLEAAAGTGIAMSVMAMVLNFFFNYVFDKIF 62
Cdd:pfam05232   1 RSLKRRVLHALLFELGLLLLLVPLLAWLLGVSLGEAGVLDIGLSLFAMVWNFVFNWLFDRLF 62
COG4125 COG4125
Uncharacterized membrane protein [Function unknown];
7-69 6.94e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 443301  Cd Length: 144  Bit Score: 37.51  E-value: 6.94e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544680679   7 IFHSVLFEIGAIAIGAVAVLLAGDFSLEAAAGTGIAMSVMAMVLNFFFNYVFDKIFTGKREER 69
Cdd:COG4125   77 ILHALGFEGGLLLILVPLIAWWLGISLWEALLLDIGLLLFFLVYTFVFNWAYDRLFPLPRSAR 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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