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Conserved domains on  [gi|544682106|ref|WP_021114142|]
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aspartate aminotransferase family protein [Glaesserella parasuis]

Protein Classification

pyridoxal phosphate-dependent decarboxylase family protein( domain architecture ID 10000562)

pyridoxal phosphate-dependent decarboxylase family protein is primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but it is also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters

CATH:  3.40.640.10
EC:  4.1.1.-
Gene Ontology:  GO:0016830|GO:0030170|GO:0019752
PubMed:  8690703|7748903
SCOP:  4003328

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 21-495 1.46e-176

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


:

Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 504.37  E-value: 1.46e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  21 DYQSSMETAVQAVSNWLQN-EKMYTGGSIKQLRSEIAFNPSKEGLGVAKSLDRLIELFLNKSLKVHHPHSLAHLHCPTMV 99
Cdd:COG0076    1 EFRALLHQALDLAADYLAGlDRPVFGPSPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVTGGTTP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 100 TSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKVGYGKGQAGVFTSGGTQSNLMGVLLARDACIAKHwknadgt 179
Cdd:COG0076   81 AALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGAGGVFTSGGTEANLLALLAARDRALARR------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 180 ewsVQRNGIPPdaMQKVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDINALEATLAKLYLEGKVVACVVATA 259
Cdd:COG0076  154 ---VRAEGLPG--APRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATA 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 260 GTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDFHKHFFQSISCGAFLLKDENEYR 339
Cdd:COG0076  229 GTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLR 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 340 YIDY-KADYLNseyDEEHGVPNLVAKSLQTTRRFDALKLWFTVEALGENLYGSMIDHGVKLTRAVADYIKATDGLELLVE 418
Cdd:COG0076  309 EAFSfHASYLG---PADDGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP 385

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544682106 419 PQFASVLFRVVPQGYPAEfvDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTLSPIATLENVQALLAQVLSEAER 495
Cdd:COG0076  386 PELNIVCFRYKPAGLDEE--DALNYALRDRLRARGRAFLSPTKLDGRVVLRLVVLNPRTTEDDVDALLDDLREAAAE 460
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 21-495 1.46e-176

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 504.37  E-value: 1.46e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  21 DYQSSMETAVQAVSNWLQN-EKMYTGGSIKQLRSEIAFNPSKEGLGVAKSLDRLIELFLNKSLKVHHPHSLAHLHCPTMV 99
Cdd:COG0076    1 EFRALLHQALDLAADYLAGlDRPVFGPSPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVTGGTTP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 100 TSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKVGYGKGQAGVFTSGGTQSNLMGVLLARDACIAKHwknadgt 179
Cdd:COG0076   81 AALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGAGGVFTSGGTEANLLALLAARDRALARR------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 180 ewsVQRNGIPPdaMQKVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDINALEATLAKLYLEGKVVACVVATA 259
Cdd:COG0076  154 ---VRAEGLPG--APRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATA 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 260 GTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDFHKHFFQSISCGAFLLKDENEYR 339
Cdd:COG0076  229 GTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLR 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 340 YIDY-KADYLNseyDEEHGVPNLVAKSLQTTRRFDALKLWFTVEALGENLYGSMIDHGVKLTRAVADYIKATDGLELLVE 418
Cdd:COG0076  309 EAFSfHASYLG---PADDGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP 385

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544682106 419 PQFASVLFRVVPQGYPAEfvDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTLSPIATLENVQALLAQVLSEAER 495
Cdd:COG0076  386 PELNIVCFRYKPAGLDEE--DALNYALRDRLRARGRAFLSPTKLDGRVVLRLVVLNPRTTEDDVDALLDDLREAAAE 460
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 90-489 1.38e-124

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 367.68  E-value: 1.38e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  90 LAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKVGYGKGQA-GVFTSGGTQSNLMGVLLARDAC 168
Cdd:cd06450    2 LAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSEDAdGVFTSGGSESNLLALLAARDRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 169 IAKHWKnadgtewsvqrngIPPDAMQKVKVVCSENAHFSVQKNMAMMGMgfqSVVTVPCNENAQMDINALEATLAKLYLE 248
Cdd:cd06450   82 RKRLKA-------------GGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAE 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 249 GKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDFHKHFFQSISCG 328
Cdd:cd06450  146 GLNPIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCS 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 329 AFLLKdeneyryidykadylnseydeehgvpnlvakslqttrrfdALKLWFTVEALGENLYGSMIDHGVKLTRAVADYIK 408
Cdd:cd06450  226 AVLVR----------------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIR 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 409 ATDGLELLVEPQFASVLFRVVpqgyPAEFVDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTLSPIATLENVQALLAQ 488
Cdd:cd06450  266 ADPGFELLGEPNLSLVCFRLK----PSVKLDELNYDLSDRLNERGGWHVPATTLGGPNVLRFVVTNPLTTRDDADALLED 341


                 .
gi 544682106 489 V 489
Cdd:cd06450  342 I 342
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
85-429 3.14e-58

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 197.26  E-value: 3.14e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106   85 HHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKVGY-----GKGQAGVFTSGGTQSNLM 159
Cdd:pfam00282  38 HSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTELENVVMNWLGEMLGLpaeflGQEGGGVLQPGSSESNLL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  160 GVLLARDACIaKHWKnADGTEWsvqrngIPPDAMQKVKVVCSENAHFSVQKNMAMMGMGFQSVvtvPCNENAQMDINALE 239
Cdd:pfam00282 118 ALLAARTKWI-KRMK-AAGKPA------DSSGILAKLVAYTSDQAHSSIEKAALYGGVKLREI---PSDDNGKMRGMDLE 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  240 ATLAKLYLEGKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDFHK 319
Cdd:pfam00282 187 KAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAYGGSAFICPEFRHWLFGIERADSITFNPHK 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  320 HFFQSISCGAFLLKDENEY-RYIDYKADYL---NSEYDEEHgvpnlvaKSLQTTRRFDALKLWFTVEALGENLYGSMIDH 395
Cdd:pfam00282 267 WMLVLLDCSAVWVKDKEALqQAFQFNPLYLghtDSAYDTGH-------KQIPLSRRFRILKLWFVIRSLGVEGLQNQIRR 339

                         330       340       350
                  ....*....|....*....|....*....|....
gi 544682106  396 GVKLTRAVADYIKATDGLELLVEPQFASVLFRVV 429
Cdd:pfam00282 340 HVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
PLN02880 PLN02880
tyrosine decarboxylase
 87-484 5.63e-38

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 145.44  E-value: 5.63e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  87 PHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWL-------REKVGYGKGqAGVFTSGGTQSNLM 159
Cdd:PLN02880  83 PNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLDWLakllnlpEQFLSTGNG-GGVIQGTASEAVLV 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 160 GVLLARDACIAKHWKNAdgtewsvqrngippdaMQKVKVVCSENAHFSVQKNMAMMGMGFQS--VVTVPCNENAQMDINA 237
Cdd:PLN02880 162 VLLAARDRVLRKVGKNA----------------LEKLVVYASDQTHSALQKACQIAGIHPENcrLLKTDSSTNYALAPEL 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 238 LEATLAKLYLEGKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDF 317
Cdd:PLN02880 226 LSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRHYIDGVEEADSFNMNA 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 318 HKHFFQSISCGAFLLKDENEY-RYIDYKADYLNSEYDEEHGVPNLVAKSLQTTRRFDALKLWFTVEALG-ENLYGSMIDH 395
Cdd:PLN02880 306 HKWFLTNFDCSLLWVKDRNALiQSLSTNPEFLKNKASQANSVVDYKDWQIPLGRRFRSLKLWMVLRLYGvENLQSYIRNH 385

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 396 gVKLTRAVADYIKATDGLELLVEPQFASVLFRVVPQGYPAEFVDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTLSP 475
Cdd:PLN02880 386 -IKLAKEFEQLVAQDSRFEVVTPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAVNSSGKIFISHTVLSGKYVLRFAVGAP 464


                 ....*....
gi 544682106 476 IATLENVQA 484
Cdd:PLN02880 465 LTEERHVTA 473
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 21-495 1.46e-176

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 504.37  E-value: 1.46e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  21 DYQSSMETAVQAVSNWLQN-EKMYTGGSIKQLRSEIAFNPSKEGLGVAKSLDRLIELFLNKSLKVHHPHSLAHLHCPTMV 99
Cdd:COG0076    1 EFRALLHQALDLAADYLAGlDRPVFGPSPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVTGGTTP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 100 TSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKVGYGKGQAGVFTSGGTQSNLMGVLLARDACIAKHwknadgt 179
Cdd:COG0076   81 AALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGAGGVFTSGGTEANLLALLAARDRALARR------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 180 ewsVQRNGIPPdaMQKVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDINALEATLAKLYLEGKVVACVVATA 259
Cdd:COG0076  154 ---VRAEGLPG--APRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATA 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 260 GTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDFHKHFFQSISCGAFLLKDENEYR 339
Cdd:COG0076  229 GTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLR 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 340 YIDY-KADYLNseyDEEHGVPNLVAKSLQTTRRFDALKLWFTVEALGENLYGSMIDHGVKLTRAVADYIKATDGLELLVE 418
Cdd:COG0076  309 EAFSfHASYLG---PADDGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP 385

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544682106 419 PQFASVLFRVVPQGYPAEfvDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTLSPIATLENVQALLAQVLSEAER 495
Cdd:COG0076  386 PELNIVCFRYKPAGLDEE--DALNYALRDRLRARGRAFLSPTKLDGRVVLRLVVLNPRTTEDDVDALLDDLREAAAE 460
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 90-489 1.38e-124

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 367.68  E-value: 1.38e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  90 LAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKVGYGKGQA-GVFTSGGTQSNLMGVLLARDAC 168
Cdd:cd06450    2 LAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSEDAdGVFTSGGSESNLLALLAARDRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 169 IAKHWKnadgtewsvqrngIPPDAMQKVKVVCSENAHFSVQKNMAMMGMgfqSVVTVPCNENAQMDINALEATLAKLYLE 248
Cdd:cd06450   82 RKRLKA-------------GGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAE 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 249 GKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDFHKHFFQSISCG 328
Cdd:cd06450  146 GLNPIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCS 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 329 AFLLKdeneyryidykadylnseydeehgvpnlvakslqttrrfdALKLWFTVEALGENLYGSMIDHGVKLTRAVADYIK 408
Cdd:cd06450  226 AVLVR----------------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIR 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 409 ATDGLELLVEPQFASVLFRVVpqgyPAEFVDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTLSPIATLENVQALLAQ 488
Cdd:cd06450  266 ADPGFELLGEPNLSLVCFRLK----PSVKLDELNYDLSDRLNERGGWHVPATTLGGPNVLRFVVTNPLTTRDDADALLED 341


                 .
gi 544682106 489 V 489
Cdd:cd06450  342 I 342
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
85-429 3.14e-58

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 197.26  E-value: 3.14e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106   85 HHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKVGY-----GKGQAGVFTSGGTQSNLM 159
Cdd:pfam00282  38 HSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTELENVVMNWLGEMLGLpaeflGQEGGGVLQPGSSESNLL 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  160 GVLLARDACIaKHWKnADGTEWsvqrngIPPDAMQKVKVVCSENAHFSVQKNMAMMGMGFQSVvtvPCNENAQMDINALE 239
Cdd:pfam00282 118 ALLAARTKWI-KRMK-AAGKPA------DSSGILAKLVAYTSDQAHSSIEKAALYGGVKLREI---PSDDNGKMRGMDLE 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  240 ATLAKLYLEGKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDFHK 319
Cdd:pfam00282 187 KAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAYGGSAFICPEFRHWLFGIERADSITFNPHK 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  320 HFFQSISCGAFLLKDENEY-RYIDYKADYL---NSEYDEEHgvpnlvaKSLQTTRRFDALKLWFTVEALGENLYGSMIDH 395
Cdd:pfam00282 267 WMLVLLDCSAVWVKDKEALqQAFQFNPLYLghtDSAYDTGH-------KQIPLSRRFRILKLWFVIRSLGVEGLQNQIRR 339

                         330       340       350
                  ....*....|....*....|....*....|....
gi 544682106  396 GVKLTRAVADYIKATDGLELLVEPQFASVLFRVV 429
Cdd:pfam00282 340 HVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
PLN02880 PLN02880
tyrosine decarboxylase
 87-484 5.63e-38

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 145.44  E-value: 5.63e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  87 PHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWL-------REKVGYGKGqAGVFTSGGTQSNLM 159
Cdd:PLN02880  83 PNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLDWLakllnlpEQFLSTGNG-GGVIQGTASEAVLV 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 160 GVLLARDACIAKHWKNAdgtewsvqrngippdaMQKVKVVCSENAHFSVQKNMAMMGMGFQS--VVTVPCNENAQMDINA 237
Cdd:PLN02880 162 VLLAARDRVLRKVGKNA----------------LEKLVVYASDQTHSALQKACQIAGIHPENcrLLKTDSSTNYALAPEL 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 238 LEATLAKLYLEGKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDF 317
Cdd:PLN02880 226 LSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRHYIDGVEEADSFNMNA 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 318 HKHFFQSISCGAFLLKDENEY-RYIDYKADYLNSEYDEEHGVPNLVAKSLQTTRRFDALKLWFTVEALG-ENLYGSMIDH 395
Cdd:PLN02880 306 HKWFLTNFDCSLLWVKDRNALiQSLSTNPEFLKNKASQANSVVDYKDWQIPLGRRFRSLKLWMVLRLYGvENLQSYIRNH 385

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 396 gVKLTRAVADYIKATDGLELLVEPQFASVLFRVVPQGYPAEFVDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTLSP 475
Cdd:PLN02880 386 -IKLAKEFEQLVAQDSRFEVVTPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAVNSSGKIFISHTVLSGKYVLRFAVGAP 464


                 ....*....
gi 544682106 476 IATLENVQA 484
Cdd:PLN02880 465 LTEERHVTA 473
PLN02590 PLN02590
probable tyrosine decarboxylase
 87-482 1.62e-37

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 144.85  E-value: 1.62e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  87 PHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIEWLREKV-------GYGKGqAGVFTSGGTQSNLM 159
Cdd:PLN02590 131 PSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLqlpdhflSTGNG-GGVIQGTGCEAVLV 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 160 GVLLARDACIAKhwknadgtewsVQRNGIPpdamqKVKVVCSENAHFSVQKNMAMMGMGFQSV--VTVPCNENAQMDINA 237
Cdd:PLN02590 210 VVLAARDRILKK-----------VGKTLLP-----QLVVYGSDQTHSSFRKACLIGGIHEENIrlLKTDSSTNYGMPPES 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 238 LEATLAKLYLEGKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVDAAWGGALLLSNEYRHFLDGIELTDSITLDF 317
Cdd:PLN02590 274 LEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNA 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 318 HKHFFQSISCGAFLLKDenEYRYID---YKADYLNSEYDEEHGVPNLVAKSLQTTRRFDALKLWFTVEALG-ENLYGSMI 393
Cdd:PLN02590 354 HKWLFANQTCSPLWVKD--RYSLIDalkTNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGsENLRNFIR 431

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 394 DHgVKLTRAVADYIKATDGLELLVEPQFASVLFRVVPQGYPAEFVDTLNQNVADELFARGEANIGVTKVNNIQSLKMTTL 473
Cdd:PLN02590 432 DH-VNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAPVDGDEDQCNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVG 510


                 ....*....
gi 544682106 474 SPIATLENV 482
Cdd:PLN02590 511 APLTEEKHV 519
PRK02769 PRK02769
histidine decarboxylase; Provisional
 147-343 1.93e-17

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 83.94  E-value: 1.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 147 GVFTSGGTQSNLMGVLLARDaciakhwknadgtewsvqrngIPPDAMqkvkVVCSENAHFSVQKNMAMMGMgfQSVVtVP 226
Cdd:PRK02769  87 GYITNGGTEGNLYGCYLARE---------------------LFPDGT----LYYSKDTHYSVSKIARLLRI--KSRV-IT 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 227 CNENAQMDINALEaTLAKLYLEGKVVacVVATAGTTDAGAIDPLKAIRAITNKFG---VWLHVDAAWGGALL--LSNEYR 301
Cdd:PRK02769 139 SLPNGEIDYDDLI-SKIKENKNQPPI--IFANIGTTMTGAIDNIKEIQEILKKIGiddYYIHADAALSGMILpfVNNPPP 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 544682106 302 H-FLDGIeltDSITLDFHKHFFQSISCGAFLLKDEN---EYRYIDY 343
Cdd:PRK02769 216 FsFADGI---DSIAISGHKFIGSPMPCGIVLAKKKYverISVDVDY 258
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 128-319 1.21e-10

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 60.09  E-value: 1.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 128 EVQLIEWLREKVGYGKgQAGVFTSGGTQSNLMGVLLARdaciakhwknADGTEwsvqrngippdamqkvkVVCSENAHFS 207
Cdd:cd01494    2 LEELEEKLARLLQPGN-DKAVFVPSGTGANEAALLALL----------GPGDE-----------------VIVDANGHGS 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 208 VqkNMAMMGMGFQSVVTVPCNENAQMDINALEATLAKLyleGKVVACVVATAGTTDAGAIDPLKAIRAITNKFGVWLHVD 287
Cdd:cd01494   54 R--YWVAAELAGAKPVPVPVDDAGYGGLDVAILEELKA---KPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVD 128

                        170       180       190
                 ....*....|....*....|....*....|..
gi 544682106 288 AAWGGALLLSNEYRHFLDGIeltDSITLDFHK 319
Cdd:cd01494  129 AASAGGASPAPGVLIPEGGA---DVVTFSLHK 157
PLN03032 PLN03032
serine decarboxylase; Provisional
 147-350 5.78e-07

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 51.75  E-value: 5.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 147 GVFTSGGTQSNLMGVLLARDaciakhwKNADGTEWSvqrngippdamqkvkvvcSENAHFSVQKNMAMMGMGFQSVVTVP 226
Cdd:PLN03032  88 GYITTCGTEGNLHGILVGRE-------VFPDGILYA------------------SRESHYSVFKAARMYRMEAVKVPTLP 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 227 CNEnaqMDINALEATLAKlyLEGKVVACVVaTAGTTDAGAIDPLKAIRAITNKFGV-----WLHVDAAWGGALLLSNEYR 301
Cdd:PLN03032 143 SGE---IDYDDLERALAK--NRDKPAILNV-NIGTTVKGAVDDLDRILRILKELGYtedrfYIHCDGALFGLMMPFVSRA 216

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 544682106 302 HFLDGIELTDSITLDFHKHFFQSISCGAFLLKDENeYRYIDYKADYLNS 350
Cdd:PLN03032 217 PEVTFRKPIGSVSVSGHKFLGCPMPCGVALTRKKH-VKALSQNVEYLNS 264
NifS COG1104
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ...
 148-289 1.89e-05

Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];


Pssm-ID: 440721 [Multi-domain]  Cd Length: 381  Bit Score: 46.97  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 148 VFTSGGTQSN---LMGVLLARDAciakhwknadgtewsvQRNGIppdamqkvkVVCS-EnaHFSVQKNM-AMMGMGFQsV 222
Cdd:COG1104   66 IFTSGGTEANnlaIKGAARAYRK----------------KGKHI---------ITSAiE--HPAVLETArFLEKEGFE-V 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544682106 223 VTVPCNENAQMDINALEATLAklylEGKVVACVVA----TagttdaGAIDPLKAIRAITNKFGVWLHVDAA 289
Cdd:COG1104  118 TYLPVDEDGRVDLEALEAALR----PDTALVSVMHanneT------GTIQPIAEIAEIAKEHGVLFHTDAV 178
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
131-289 1.62e-04

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 43.74  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  131 LIEWLREKVGYgkgQAGVFTSGGTQSN--LMGVLLARdaciakhwknadGTEwsvqrngippdamqkvkVVCSENAH--F 206
Cdd:pfam01212  37 LEDRVAELFGK---EAALFVPSGTAANqlALMAHCQR------------GDE-----------------VICGEPAHihF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106  207 SVQKNMAMMGmGFQsVVTVPCNENAQMDINALEATLA--KLYLEGKVVACVVATAGTTDAGAIDP---LKAIRAITNKFG 281
Cdd:pfam01212  85 DETGGHAELG-GVQ-PRPLDGDEAGNMDLEDLEAAIRevGADIFPPTGLISLENTHNSAGGQVVSlenLREIAALAREHG 162


                  ....*...
gi 544682106  282 VWLHVDAA 289
Cdd:pfam01212 163 IPVHLDGA 170
PLN02721 PLN02721
threonine aldolase
 141-289 6.11e-04

threonine aldolase


Pssm-ID: 178323 [Multi-domain]  Cd Length: 353  Bit Score: 41.98  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 141 YGKgQAGVFTSGGTQSNLMGVLLardaciakhWKNADGTEwsvqrngippdamqkvkVVCSENAHFSVQKNMAMMGMGFQ 220
Cdd:PLN02721  53 FGK-EAALFVPSGTMGNLISVLV---------HCDVRGSE-----------------VILGDNSHIHLYENGGISTLGGV 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544682106 221 SVVTVPCNENAQMDINALEATL----AKLYLEGKVVaCVVATAGTTdAGAIDPLKAIRAI---TNKFGVWLHVDAA 289
Cdd:PLN02721 106 HPRTVKNNEDGTMDLDAIEAAIrpkgDDHFPTTRLI-CLENTHANC-GGRCLSVEYTDKVgelAKRHGLKLHIDGA 179
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
222-289 7.38e-03

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 38.58  E-value: 7.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544682106 222 VVTVPCNENAQMDINALEATL-AKLylegKVVACVVATAGTtdaGAIDPLKAIRAITNKFGVWLHVDAA 289
Cdd:COG0520  131 VRVIPLDEDGELDLEALEALLtPRT----KLVAVTHVSNVT---GTVNPVKEIAALAHAHGALVLVDGA 192
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 125-289 8.40e-03

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 38.37  E-value: 8.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 125 SLMEVQliEWLREKVGYGKGQAGVFTSGGTQSNLMGVLLARdaciAKHWKNadgtewsvqrngippdamqkvKVVCSENA 204
Cdd:cd00613   65 ALFELQ--TMLCELTGMDVANASLQDEATAAAEAAGLAAIR----AYHKRN---------------------KVLVPDSA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544682106 205 HFSVQKNMAMMGMGFQ-SVVTVPCNENAQMDINALEATLaklyleGKVVACVVATAGTTDaGAI-DPLKAIRAITNKFGV 282
Cdd:cd00613  118 HPTNPAVARTRGEPLGiEVVEVPSDEGGTVDLEALKEEV------SEEVAALMVQYPNTL-GVFeDLIKEIADIAHSAGA 190


                 ....*..
gi 544682106 283 WLHVDAA 289
Cdd:cd00613  191 LVYVDGD 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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