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Conserved domains on  [gi|544684571|ref|WP_021116421|]
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GntR family transcriptional regulator [Glaesserella parasuis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARO8 super family cl43346
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-31 1.48e-06

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


The actual alignment was detected with superfamily member COG1167:

Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 43.66  E-value: 1.48e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 544684571   1 MYKYTKLTQHLKHLIETGELKPHEKLPSLRD 31
Cdd:COG1167   11 GPLYLQLADALREAILSGRLPPGDRLPSSRE 41
 
Name Accession Description Interval E-value
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-31 1.48e-06

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 43.66  E-value: 1.48e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 544684571   1 MYKYTKLTQHLKHLIETGELKPHEKLPSLRD 31
Cdd:COG1167   11 GPLYLQLADALREAILSGRLPPGDRLPSSRE 41
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 3-31 3.64e-06

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 40.12  E-value: 3.64e-06
                        10        20
                ....*....|....*....|....*....
gi 544684571  3 KYTKLTQHLKHLIETGELKPHEKLPSLRD 31
Cdd:cd07377   2 LYEQIADQLREAILSGELKPGDRLPSERE 30
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 3-36 3.54e-04

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 34.90  E-value: 3.54e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 544684571   3 KYTKLTQHLKHLIETGELKPHEKLPSLRD-QTAFG 36
Cdd:pfam00392  1 LYEQVYARLREDILSGRLRPGDKLPSERElAAEFG 35
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-31 2.30e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 32.93  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|...
gi 544684571    9 QHLKHLIETGELKPHEKLPSLRD 31
Cdd:smart00345  3 ERLREDIVSGELRPGDKLPSERE 25
 
Name Accession Description Interval E-value
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-31 1.48e-06

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 43.66  E-value: 1.48e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 544684571   1 MYKYTKLTQHLKHLIETGELKPHEKLPSLRD 31
Cdd:COG1167   11 GPLYLQLADALREAILSGRLPPGDRLPSSRE 41
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 3-31 3.64e-06

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 40.12  E-value: 3.64e-06
                        10        20
                ....*....|....*....|....*....
gi 544684571  3 KYTKLTQHLKHLIETGELKPHEKLPSLRD 31
Cdd:cd07377   2 LYEQIADQLREAILSGELKPGDRLPSERE 30
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
4-31 2.30e-05

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 39.01  E-value: 2.30e-05
                         10        20
                 ....*....|....*....|....*...
gi 544684571   4 YTKLTQHLKHLIETGELKPHEKLPSLRD 31
Cdd:COG1725   12 YEQIADQIKEAIASGELKPGDRLPSVRE 39
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-53 1.08e-04

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 38.30  E-value: 1.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544684571   3 KYTKLTQHLKHLIETGELKPHEKLPSLRDqtaFGAEF---------------DDGIkrLSRVRGSG 53
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERE---LAEEFgvsrmtvrkaldelvEEGL--LERRQGRG 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 3-36 3.54e-04

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 34.90  E-value: 3.54e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 544684571   3 KYTKLTQHLKHLIETGELKPHEKLPSLRD-QTAFG 36
Cdd:pfam00392  1 LYEQVYARLREDILSGRLRPGDKLPSERElAAEFG 35
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-31 2.30e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 32.93  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|...
gi 544684571    9 QHLKHLIETGELKPHEKLPSLRD 31
Cdd:smart00345  3 ERLREDIVSGELRPGDKLPSERE 25
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-31 2.97e-03

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 34.14  E-value: 2.97e-03
                         10        20
                 ....*....|....*....|....*...
gi 544684571   4 YTKLTQHLKHLIETGELKPHEKLPSLRD 31
Cdd:COG2186    9 AEQVAEQLRELILSGELKPGDRLPSERE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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