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Conserved domains on  [gi|544824380|ref|WP_021240383|]
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MULTISPECIES: T6SS effector amidase Tae4 family protein [Enterobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tae4 super family cl16625
Type VI secretion system (T6SS), amidase effector protein 4; Tae4 is a new form of ...
 46-161 3.34e-18

Type VI secretion system (T6SS), amidase effector protein 4; Tae4 is a new form of toxin-antitoxin system protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the recipient cells of closely related species. Pseudomonas aeruginosa produces at least three effector proteins to other cells and thus has three specific cognate immunity proteins to protect itself. Tae4, or type VI amidase effector 4, in Enterobacter cloacae has a cognate Tai4 or type VI amidase immunity 4 protein. The immunity protein is Tai4, pfam16695.


The actual alignment was detected with superfamily member pfam14113:

Pssm-ID: 433727  Cd Length: 115  Bit Score: 75.10  E-value: 3.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824380   46 YENTCAVRMSLALLKCNVEF-TGRLPIKSG-PYKGKTIEPGAKLLADQLYKSH-VFGKAEIFTDREaGARSMLGRKGVVF 122
Cdd:pfam14113   1 YENTCAIRVSYALNYSGVPIkTFSGKRCCGkGVRGKGYIIRAAELANWLTKKWgKLGKPEIYADIT-GNDKLKGRKGIIV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 544824380  123 FnKIDGYG--GGHIDLIeplsNNSFICNSDCFPYCQEIWFW 161
Cdd:pfam14113  80 F-KDYGFGdaTGHIDLW----NGSDCSDECYFNNSKDIWFW 115
 
Name Accession Description Interval E-value
Tae4 pfam14113
Type VI secretion system (T6SS), amidase effector protein 4; Tae4 is a new form of ...
 46-161 3.34e-18

Type VI secretion system (T6SS), amidase effector protein 4; Tae4 is a new form of toxin-antitoxin system protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the recipient cells of closely related species. Pseudomonas aeruginosa produces at least three effector proteins to other cells and thus has three specific cognate immunity proteins to protect itself. Tae4, or type VI amidase effector 4, in Enterobacter cloacae has a cognate Tai4 or type VI amidase immunity 4 protein. The immunity protein is Tai4, pfam16695.


Pssm-ID: 433727  Cd Length: 115  Bit Score: 75.10  E-value: 3.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824380   46 YENTCAVRMSLALLKCNVEF-TGRLPIKSG-PYKGKTIEPGAKLLADQLYKSH-VFGKAEIFTDREaGARSMLGRKGVVF 122
Cdd:pfam14113   1 YENTCAIRVSYALNYSGVPIkTFSGKRCCGkGVRGKGYIIRAAELANWLTKKWgKLGKPEIYADIT-GNDKLKGRKGIIV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 544824380  123 FnKIDGYG--GGHIDLIeplsNNSFICNSDCFPYCQEIWFW 161
Cdd:pfam14113  80 F-KDYGFGdaTGHIDLW----NGSDCSDECYFNNSKDIWFW 115
 
Name Accession Description Interval E-value
Tae4 pfam14113
Type VI secretion system (T6SS), amidase effector protein 4; Tae4 is a new form of ...
 46-161 3.34e-18

Type VI secretion system (T6SS), amidase effector protein 4; Tae4 is a new form of toxin-antitoxin system protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the recipient cells of closely related species. Pseudomonas aeruginosa produces at least three effector proteins to other cells and thus has three specific cognate immunity proteins to protect itself. Tae4, or type VI amidase effector 4, in Enterobacter cloacae has a cognate Tai4 or type VI amidase immunity 4 protein. The immunity protein is Tai4, pfam16695.


Pssm-ID: 433727  Cd Length: 115  Bit Score: 75.10  E-value: 3.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824380   46 YENTCAVRMSLALLKCNVEF-TGRLPIKSG-PYKGKTIEPGAKLLADQLYKSH-VFGKAEIFTDREaGARSMLGRKGVVF 122
Cdd:pfam14113   1 YENTCAIRVSYALNYSGVPIkTFSGKRCCGkGVRGKGYIIRAAELANWLTKKWgKLGKPEIYADIT-GNDKLKGRKGIIV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 544824380  123 FnKIDGYG--GGHIDLIeplsNNSFICNSDCFPYCQEIWFW 161
Cdd:pfam14113  80 F-KDYGFGdaTGHIDLW----NGSDCSDECYFNNSKDIWFW 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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