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Conserved domains on  [gi|544824529|ref|WP_021240531|]
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MULTISPECIES: 3-isopropylmalate dehydrogenase [Enterobacter]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 704.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   3 KNYHIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWE 82
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  83 HLPPAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQHEKAF 162
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 163 DTEVYHRFEIERIAHIAFESARKRRHKVTSIDKANVLQSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATAI 322
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 544824529 323 ENAINRALEEGVRTGDLSRGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 704.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   3 KNYHIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWE 82
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  83 HLPPAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQHEKAF 162
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 163 DTEVYHRFEIERIAHIAFESARKRRHKVTSIDKANVLQSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATAI 322
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 544824529 323 ENAINRALEEGVRTGDLSRGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-355 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 605.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529    6 HIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWEHLP 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   86 PAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAaNGFDILCVRELTGGIYFGQPKGREGSGqheKAFDTE 165
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  166 VYHRFEIERIAHIAFESARKRRHKVTSIDKANVLQSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDVLLC 245
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  246 SNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATAIENA 325
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 544824529  326 INRALEEGVRTGDLSRGA-AAVSTDEMGDII 355
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSSAtTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 586.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   4 NYHIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWeh 83
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  84 lPPAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEefCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQHEKAFD 163
Cdd:COG0473   79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 164 TEVYHRFEIERIAHIAFESARKRRHKVTSIDKANVL-QSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDV 242
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDAATAI 322
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 544824529 323 ENAINRALEEGVRTGDLsrgAAAVSTDEMGDIIARYV 359
Cdd:COG0473  313 EAAVEKVLAEGVRTPDL---GGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 537.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529    6 HIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWEhlP 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   86 PAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAanGFDILCVRELTGGIYFGQPKGREGSGQhEKAFDTE 165
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGN-EVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  166 VYHRFEIERIAHIAFESARKR-RHKVTSIDKANVLQSSILWREIVSEVAK-QYPDVELSHMYIDNATMQLIKDPSQFDVL 243
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  244 LCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATAIE 323
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 544824529  324 NAINRALEEGVRTGDLSRGAAAVSTDEMGDII 355
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 704.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   3 KNYHIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWE 82
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  83 HLPPAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQHEKAF 162
Cdd:PRK00772  81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 163 DTEVYHRFEIERIAHIAFESARKRRHKVTSIDKANVLQSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772 159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATAI 322
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 544824529 323 ENAINRALEEGVRTGDLSRGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772 319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-355 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 605.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529    6 HIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWEHLP 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   86 PAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAaNGFDILCVRELTGGIYFGQPKGREGSGqheKAFDTE 165
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  166 VYHRFEIERIAHIAFESARKRRHKVTSIDKANVLQSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDVLLC 245
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  246 SNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATAIENA 325
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 544824529  326 INRALEEGVRTGDLSRGA-AAVSTDEMGDII 355
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSSAtTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 586.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   4 NYHIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWeh 83
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  84 lPPAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEefCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQHEKAFD 163
Cdd:COG0473   79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 164 TEVYHRFEIERIAHIAFESARKRRHKVTSIDKANVL-QSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDV 242
Cdd:COG0473  154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDAATAI 322
Cdd:COG0473  234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 544824529 323 ENAINRALEEGVRTGDLsrgAAAVSTDEMGDIIARYV 359
Cdd:COG0473  313 EAAVEKVLAEGVRTPDL---GGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 537.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529    6 HIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWEhlP 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   86 PAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAanGFDILCVRELTGGIYFGQPKGREGSGQhEKAFDTE 165
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGN-EVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  166 VYHRFEIERIAHIAFESARKR-RHKVTSIDKANVLQSSILWREIVSEVAK-QYPDVELSHMYIDNATMQLIKDPSQFDVL 243
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  244 LCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATAIE 323
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 544824529  324 NAINRALEEGVRTGDLSRGAAAVSTDEMGDII 355
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 3-363 7.28e-119

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 350.14  E-value: 7.28e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   3 KNYHIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWE 82
Cdd:PLN02329  45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWD 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  83 HLPPAEQPERGaLLPLRKHFKLFSNLRPAKLYQGLEEFCPLRADIAaNGFDILCVRELTGGIYFGQPKG-REGSGQHEKA 161
Cdd:PLN02329 125 KNEKHLRPEMA-LFYLRRDLKVFANLRPATVLPQLVDASTLKKEVA-EGVDMMIVRELTGGIYFGEPRGiTINENGEEVG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 162 FDTEVYHRFEIERIAHIAFESARKRRHKVTSIDKANVLQSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFD 241
Cdd:PLN02329 203 VSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAGDAATA 321
Cdd:PLN02329 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKR 362

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 544824529 322 IENAINRALEEGVRTGDL-SRGAAAVSTDEMGDIIARYVAEGV 363
Cdd:PLN02329 363 IEDAVVDALNKGFRTGDIySPGNKLVGCKEMGEEVLKSVDSKV 405
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-359 1.45e-102

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 306.08  E-value: 1.45e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   1 MSKNYHIAVLPGDGIGPEVMAQALKVLEAVRARfAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPK 80
Cdd:PRK03437   1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  81 wehLPPAEQpERGALLPLRKHFKLFSNLRPAKLYQGLEefCPLradiAANG-FDILCVRELTGGIYFGQpkG---REGSg 156
Cdd:PRK03437  80 ---VPSGVL-ERGLLLKLRFALDHYVNLRPSKLYPGVT--SPL----AGPGdIDFVVVREGTEGPYTGN--GgalRVGT- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 157 QHEKAFDTEVYHRFEIERIAHIAFESARKR-RHKVTSIDKANVL-QSSILWREIVSEVAKQYPDVELSHMYIDNATMQLI 234
Cdd:PRK03437 147 PHEVATEVSVNTAFGVERVVRDAFERAQKRpRKHLTLVHKTNVLtFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFG--LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYs 312
Cdd:PRK03437 227 TDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH- 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 544824529 313 LDAGDAATAIENAINRALEEgvrtgdlsRGAAAVSTDEMGDIIARYV 359
Cdd:PRK03437 306 LGEEDAAARIEAAVEADLAE--------RGKMGRSTAEVGDRIAARL 344
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 3-356 1.07e-89

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 273.63  E-value: 1.07e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529    3 KNYHIAVLPGDGIGPEVMAQALKVLEAVRARFA-MKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKw 81
Cdd:TIGR02089   2 KQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   82 ehLPPAEQPERGALLPLRKHFKLFSNLRPAKLYQGLEEfcPLRADiAANGFDILCVRELTGGIYFGQpKGREGSG-QHEK 160
Cdd:TIGR02089  81 --LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTS--PLRNC-GPGDFDFVVVRENSEGEYSGV-GGRIHRGtDEEV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  161 AFDTEVYHRFEIERIAHIAFESARKRRHKVTSIDKANVLQSSI-LWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQ 239
Cdd:TIGR02089 155 ATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPET 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGF--GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGD 317
Cdd:TIGR02089 235 FDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKE 313

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 544824529  318 AATAIENAINRALEEGVRTGDLSRGAaavSTDEMGDIIA 356
Cdd:TIGR02089 314 AGAKIMDAIERVTAAGILTPDVGGKA---TTSEVTEAVC 349
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 5-359 1.15e-85

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 262.38  E-value: 1.15e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   5 YHIAVLPGDGIGPEVMAQALKVLEAVRARFAMkittSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGgpkwehl 84
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEF----VYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  85 ppaeQPERGALLPLRKHFKLFSNLRPAKLYQGLEefCpLRADIaangfDILCVRELTGGIYfgqpKGREGSGQHEKAFDT 164
Cdd:PRK14025  71 ----ETAADVIVKLRRILDTYANVRPVKSYKGVK--C-LYPDI-----DYVIVRENTEGLY----KGIEAEIADGVTVAT 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 165 EVYHRFEIERIAHIAFESARKR-----RHKVTSIDKANVLQSSI-LWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPS 238
Cdd:PRK14025 135 RVITRKASERIFRFAFEMAKRRkkmgkEGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQ 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEgFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDA 318
Cdd:PRK14025 215 TFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDK-YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEE 292

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 544824529 319 ATAIENAINRALEEGVRTGDLsrgAAAVSTDEMGDIIARYV 359
Cdd:PRK14025 293 ADKVEKALEEVLALGLTTPDL---GGNLSTMEMAEEVAKRV 330
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 3-357 2.32e-84

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 259.65  E-value: 2.32e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   3 KNYHIAVLPGDGIGPEVMAQALKVLEAV-RARFAMKITTSHYDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKw 81
Cdd:PRK08194   2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVaEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  82 ehLPPAEQPERGALLPLRKHFKLFSNLRPAKLYQGLEEfcPLRAdiaANGFDILCVRELTGGIYfGQPKGREGSGQHEKA 161
Cdd:PRK08194  81 --LVPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKS--PLAN---PKDFDLLVVRENSEGEY-SEVGGRIHRGEDEIA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 162 FDTEVYHRFEIERIAHIAFESARKRRHKVTSIDKAN-VLQSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQF 240
Cdd:PRK08194 153 IQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEF 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGF--GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDA 318
Cdd:PRK08194 233 DVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEEEL 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 544824529 319 ATAIENAINRALEEGVRTGDLsrGAAAvSTDEMGD-IIAR 357
Cdd:PRK08194 312 GSHLLDVIEDVTEDGIKTPDI--GGRA-TTDEVTDeIISR 348
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 7-357 1.04e-80

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 249.64  E-value: 1.04e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   7 IAVLPGDGIGPEVMAQALKVLEAVRARFAMKITtshyDVGGIAIDNHGTPLPKATVEGCENADAVLFGSVGGPKWEHLPP 86
Cdd:PRK08997   5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYEFA----DAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  87 AEqpergalLPLRKHFKLFSNLRPAKLYQGLEEfcplRADiaanGFDILCVRELTGGIYFGQpkGREGSGQHEKAFDTEV 166
Cdd:PRK08997  81 IN-------VTLRKKFDLYANVRPVLSFPGTKA----RYD----NIDIITVRENTEGMYSGE--GQTVSEDGETAEATSI 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 167 YHRFEIERIAHIAFESARKR-RHKVTSIDKANVLQS-SILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDVLL 244
Cdd:PRK08997 144 ITRKGAERIVRFAYELARKEgRKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIV 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 245 CSNLFGDILSDECAMITGSMGMLPSASLNEEGfGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDAATAIEN 324
Cdd:PRK08997 224 TTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAERIRK 301

                        330       340       350
                 ....*....|....*....|....*....|....
gi 544824529 325 AINRALEEGVR-TGDLsrGAAAVSTDEMGDIIAR 357
Cdd:PRK08997 302 AIVAVIEAGDRtTRDL--GGTHGTTDFTQAVIDR 333
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-357 6.12e-62

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 205.51  E-value: 6.12e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   1 MSKNYHIAVLPGDGIGPEVMAQALKVLEAVRARFAMKITtshyDVG------GIAidnHGtpLPKATVEGCENADAVLFG 74
Cdd:PRK09222   1 MAEKTPITVAYGDGIGPEIMEAVLKILEAAGAPLEIETI----EIGekvykkGWT---SG--ISPSAWESIRRTKVLLKA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  75 svggpkwehlpPAEQPERG----ALLPLRKHFKLFSNLRPAKLYqglEEFCPLRADiaanGFDILCVRE----LTGGIYF 146
Cdd:PRK09222  72 -----------PITTPQGGgyksLNVTLRKTLGLYANVRPCVSY---HPFVETKHP----NLDVVIIREneedLYAGIEH 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 147 GQpkgregsgqhekafDTEVYHRFEI------ERIAHIAFESARKR-RHKVTSIDKANVL-QSSILWREIVSEVAKQYPD 218
Cdd:PRK09222 134 RQ--------------TPDVYQCLKLisrpgsEKIIRYAFEYARANgRKKVTCLTKDNIMkLTDGLFHKVFDEIAKEYPD 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 219 VELSHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGfGLYEPAGGSAPDIAGKNIANP 298
Cdd:PRK09222 200 IEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANP 278

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544824529 299 IAQILSLALLLRYsLDAGDAATAIENAINRALEEGVRTGDL---SRGAAAVSTDEMGD-IIAR 357
Cdd:PRK09222 279 SGLLNAAVMMLVH-IGQFDIAELIENAWLKTLEDGIHTADIyneGVSKKKVGTKEFAEaVIEN 340
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 9-349 1.91e-51

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 175.45  E-value: 1.91e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   9 VLPGDGIGPEVMAQALKVLEAVRARFAMKittSHYdVGGiaidnhgTPLPKA-TVEGCENADAVLFGSVG--GPKwehLP 85
Cdd:PLN00118  46 LFPGDGIGPEIAESVKQVFTAAGVPIEWE---EHY-VGT-------TVDPRTgSFLTWESLESVRRNKVGlkGPM---AT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  86 PAEQPERGALLPLRKHFKLFSNLRPAKLYQGLEEfcplRADiaanGFDILCVRELTGGIYfgqpKGREGSGQHEKAFDTE 165
Cdd:PLN00118 112 PIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKT----RYD----DVDLVTIRENTEGEY----SGLEHQVVRGVVESLK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 166 VYHRFEIERIAHIAFESARKR-RHKVTSIDKANVLQSSI-LWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQFDVL 243
Cdd:PLN00118 180 IITRQASLRVAEYAFHYAKTHgRKRVSAIHKANIMKKTDgLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVL 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDAATAIE 323
Cdd:PLN00118 260 VMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIH 338

                        330       340
                 ....*....|....*....|....*..
gi 544824529 324 NAINRALEEG-VRTGDLsrGAAAVSTD 349
Cdd:PLN00118 339 NAILNTIAEGkYRTADL--GGSSTTTD 363
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 12-357 1.91e-40

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 147.18  E-value: 1.91e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  12 GDGIGPEVMAQALKVL-EAVRARFAM--KITTSHYDVGGIAIDNHGTPLPKATVEGCENadavlFG-SVGGPkwehL-PP 86
Cdd:COG0538   26 GDGIGPEITRAIWKVIdAAVEKAYGGkrDIEWKEVDAGEKARDETGDWLPDETAEAIKE-----YGvGIKGP----LtTP 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  87 AEQPER---GALlplRKHFKLFSNLRPAKLYQGLEEfcPLRAdiaANGFDILCVRELTGGIY------FGQPK------- 150
Cdd:COG0538   97 VGGGWRslnVTI---RQILDLYVCRRPVRYFKGVPS--PVKH---PEKVDIVIFRENTEDIYagiewkAGSPEalkliff 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 151 GREGSGQHEKAFDTEV------YHRFEIERIAHIAFESA--RKRRHkVTSIDKANvlqssIL------WREIVSEVAKQ- 215
Cdd:COG0538  169 LEDEMGVTVIRFPEDSgigikpVSDEGTERLVRAAIQYAldNKRKS-VTLVHKGN-----IMkftegaFKDWGYEVAEEe 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 216 YPDVELS-------------------HMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEG 276
Cdd:COG0538  243 FGDKFITegpwekykgpkpagkivykDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDAATAIENAINRALEEGVRTGDLSR---GAAAVSTDEMGD 353
Cdd:COG0538  323 GAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLARlmeGATELSTSEFGD 401


                 ....*
gi 544824529 354 -IIAR 357
Cdd:COG0538  402 aIIEN 406
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
12-353 1.23e-38

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 142.28  E-value: 1.23e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  12 GDGIGPEVMAQALKVLE-AVRARFAMKITTSHYDV--GGIAIDNHGTPLPKATVEGCENADAVLFGSVGGP---KWEHLP 85
Cdd:PRK06451  31 GDGIGPEITHAAMKVINkAVEKAYGSDREIKWVEVlaGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkGWKSIN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  86 PAeqpergallpLRKHFKLFSNLRPAKLYQGLEEfcPLRAdiaANGFDILCVRELTGGIYfgqpKGREGSGQHEKA---- 161
Cdd:PRK06451 111 VA----------IRLMLDLYANIRPVKYIPGIES--PLKN---PEKIDLIIFRENTDDLY----RGIEYPYDSEEAkkir 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 162 -F-----------DT----EVYHRFEIERIAHIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVSEVA-KQYPDV--- 219
Cdd:PRK06451 172 dFlrkelgvevedDTgigiKLISKFKTQRIARMAIKYAiDHKRKKVTIMHKGNVMKyTEGAFREWAYEVAlKEFRDYvvt 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 220 --ELSHMYI---------------DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGfGLYEP 282
Cdd:PRK06451 252 eeEVTKNYNgvppsgkviindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMFEA 330

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544824529 283 AGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDAATAIENAINRALEEGVRTGDLSR--GAAAVSTDEMGD 353
Cdd:PRK06451 331 IHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfmGVRALSTTEYTD 402
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 7-339 5.01e-35

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 131.53  E-value: 5.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   7 IAVLPGDGIGPEVMAQALKVLEAVRArfamKITTSHYDVGGIAIDnhgtpLPKATVEGCENADAVLFGSVGGPKWEHLPP 86
Cdd:PLN00123  33 VTLIPGDGIGPLVTGAVEQVMEAMHA----PVYFERYEVHGDMKK-----VPEEVLESIRRNKVCLKGGLATPVGGGVSS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  87 AEqpergalLPLRKHFKLFSNLRPAKLYQGLeefcPLRADiaanGFDILCVRELTGGIYFGQpkgregsgQHEKA----F 162
Cdd:PLN00123 104 LN-------VQLRKELDLFASLVNCFNLPGL----PTRHE----NVDIVVIRENTEGEYSGL--------EHEVVpgvvE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 163 DTEVYHRFEIERIAHIAFESAR-KRRHKVTSIDKANVL-QSSILWREIVSEVAKQYPDVELSHMYIDNATMQLIKDPSQF 240
Cdd:PLN00123 161 SLKVITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMkLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNeEGFGLYEpAGGSAPDIAGKNI-----ANPIAQILSLALLLRYsLDA 315
Cdd:PLN00123 241 DVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG-ADHAVFE-QGASAGNVGNEKLveqkkANPVALLLSSAMMLRH-LQF 317

                        330       340
                 ....*....|....*....|....*
gi 544824529 316 GDAATAIENAINRALEEG-VRTGDL 339
Cdd:PLN00123 318 PSFADRLETAVKRVIAEGkYRTKDL 342
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 7-355 2.79e-18

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 85.50  E-value: 2.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529   7 IAVLPGDGIGPEVMAQALKVLEA-VRARFAMKITTSHYDV--GGIAIDNHGTP--LPKATVEGCEnaDAVLfgSVGGPKw 81
Cdd:PRK07006  22 IPFIEGDGIGPDITPAMLKVVDAaVEKAYKGERKISWMEIyaGEKATKVYGEDvwLPEETLDLIR--EYRV--AIKGPL- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529  82 ehLPPAEQPERGALLPLRKHFKLFSNLRPAKLYQGLEEfcPLRAdiaANGFDILCVRELTGGIYFGQpKGREGSGQHEKA 161
Cdd:PRK07006  97 --TTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPS--PVKR---PEDTDMVIFRENSEDIYAGI-EWKAGSAEAKKV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 162 FD--------TEVyhRFE--------------IERIAHIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVSEVAKQYP 217
Cdd:PRK07006 169 IKflqeemgvKKI--RFPetsgigikpvseegTERLVRAAIEYAiDNDRKSVTLVHKGNIMKfTEGAFKDWGYQLAEEEF 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 218 DVEL----SHMYIDNATMQ---LIKD-------------PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEeGF 277
Cdd:PRK07006 247 GDELidggPWDKIKNPETGkeiIVKDsiadaflqqillrPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIND-GH 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 278 GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDAGDAATAIENAINRALEEGVRTGDLSR---GAAAVSTDEMGDI 354
Cdd:PRK07006 326 AIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFARlmeGATEVKCSEFGDA 404


                 .
gi 544824529 355 I 355
Cdd:PRK07006 405 L 405
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
227-341 3.93e-11

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 63.96  E-value: 3.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGfGLYEPAGGSAPDIAGKNIANPIAQILSLA 306
Cdd:PRK07362 340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGV 418

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 544824529 307 LLLRYsLDAGDAATAIENAINRALEEGVRTGDLSR 341
Cdd:PRK07362 419 MMLEY-LGWQEAADLITKGLSAAIANKQVTYDLAR 452
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 217-356 8.80e-05

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 44.25  E-value: 8.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 217 PDVELSHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPS--ASLNEEGFGL--YEPAGGSAPD--- 289
Cdd:PLN00096 235 SGDELVHLLSDAATMKLVVWTDGGFGMAAHNYDGDVLTDELAQVHKSPGFITSnlVGVDENGTLIkeFEASHGTVTDmde 314

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544824529 290 --IAGKNIA-NPIAQILSLALLLRYSLDAGDAATAI-------ENAINRALEEGVRTGDLSrGAAAVSTDEMGDIIA 356
Cdd:PLN00096 315 arLRGEETSlNPLGMVEGLIGAMNHAADVHGGKERVhpftaklRAVIHKLFREGRGTRDLC-GAGGLTTEQFIDAVA 390
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 223-357 1.36e-04

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 43.44  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 223 HMYIDNATMQLIKDPSQFdVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFG-LYEPAGGS------APDIAGKNI 295
Cdd:PTZ00435 249 HRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTvEAEAAHGTvtrhyrQHQKGKETS 327

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544824529 296 ANPIAQIL--SLALLLRYSLDAGDA----ATAIENAINRALEEGVRTGDLS---RGAAAVS------TDEMGDIIAR 357
Cdd:PTZ00435 328 TNSIASIFawTRGLAHRAKLDNNQElvkfCQALERSCIETIEAGFMTKDLAicvHGSSKVTrsdylnTEEFIDKVAE 404
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
223-339 1.64e-03

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 40.22  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824529 223 HMYIDNATMQLIKDPSQFdVLLCSNLFGDILSDECAMITGSMGMLPSASLNEEGFGL-YEPAGGSAPD-----IAGKNIA 296
Cdd:PRK08299 246 HRLIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVeAEAAHGTVTRhyrqhQKGEETS 324

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 544824529 297 -NPIAQIL--SLALLLRYSLDAGDA----ATAIENAINRALEEGVRTGDL 339
Cdd:PRK08299 325 tNPIASIFawTRGLAHRGKLDGNPElvkfADTLEKVCIETVESGFMTKDL 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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