NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|544824560|ref|WP_021240562|]
View 

MULTISPECIES: peroxide stress protein YaaA [Enterobacter]

Protein Classification

peroxide stress protein YaaA( domain architecture ID 10011746)

peroxide stress protein YaaA lowers the intracellular level of iron and therefore reduces toxicity of hydogen peroxide via an unknown mechanism

Gene Symbol:  yaaA
PubMed:  21378183
SCOP:  4004292

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK02101 PRK02101
peroxide stress protein YaaA;
1-257 1.60e-155

peroxide stress protein YaaA;


:

Pssm-ID: 234999  Cd Length: 255  Bit Score: 432.34  E-value: 1.60e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560   1 MLILISPAKTLDYQSPLATERYTQPELLDYSQQLIREARKLSAPQIASLMSISDKLADLNATRFHEWHPDFTPANARQAI 80
Cdd:PRK02101   1 MLILISPAKTLDYDGPLDTDRLSQPELLDQSQELLDALRELSPDDLASLMKISDKLAGLNAARFQDWQPEFTTANARPAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560  81 LAFKGDVYTGLQAEDFSEADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENAKGKDLYHFWGDIITDKLNAAlr 160
Cdd:PRK02101  81 LAFTGDVYDGLDADSLSEADLDYAQQHLRILSGLYGLLRPLDLIQPYRLEMGTKLPNPRGKNLYAFWGDIITQALNEA-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560 161 AQGDNVVINLASDEYYKSVKPKKLDADIIKPVFLDEKNGKFKVISFYAKKARGLMSRYIIQNRLTKPEQLTAFNSEGYFF 240
Cdd:PRK02101 159 AQGDEVLVNLASSEYFKAVKPKKLKARVITPVFLEEKNGKYKVISFYAKKARGLMARYLIENRITTPEDLKDFNFAGYAF 238
                        250
                 ....*....|....*..
gi 544824560 241 DEEASGKGELVFKRHEQ 257
Cdd:PRK02101 239 DEELSTDDELVFVRKEQ 255
 
Name Accession Description Interval E-value
PRK02101 PRK02101
peroxide stress protein YaaA;
1-257 1.60e-155

peroxide stress protein YaaA;


Pssm-ID: 234999  Cd Length: 255  Bit Score: 432.34  E-value: 1.60e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560   1 MLILISPAKTLDYQSPLATERYTQPELLDYSQQLIREARKLSAPQIASLMSISDKLADLNATRFHEWHPDFTPANARQAI 80
Cdd:PRK02101   1 MLILISPAKTLDYDGPLDTDRLSQPELLDQSQELLDALRELSPDDLASLMKISDKLAGLNAARFQDWQPEFTTANARPAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560  81 LAFKGDVYTGLQAEDFSEADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENAKGKDLYHFWGDIITDKLNAAlr 160
Cdd:PRK02101  81 LAFTGDVYDGLDADSLSEADLDYAQQHLRILSGLYGLLRPLDLIQPYRLEMGTKLPNPRGKNLYAFWGDIITQALNEA-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560 161 AQGDNVVINLASDEYYKSVKPKKLDADIIKPVFLDEKNGKFKVISFYAKKARGLMSRYIIQNRLTKPEQLTAFNSEGYFF 240
Cdd:PRK02101 159 AQGDEVLVNLASSEYFKAVKPKKLKARVITPVFLEEKNGKYKVISFYAKKARGLMARYLIENRITTPEDLKDFNFAGYAF 238
                        250
                 ....*....|....*..
gi 544824560 241 DEEASGKGELVFKRHEQ 257
Cdd:PRK02101 239 DEELSTDDELVFVRKEQ 255
YaaA COG3022
DNA-binding protein YaaA associated with the oxidative stress response [Replication, ...
2-254 1.19e-152

DNA-binding protein YaaA associated with the oxidative stress response [Replication, recombination and repair];


Pssm-ID: 442258  Cd Length: 250  Bit Score: 424.96  E-value: 1.19e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560   2 LILISPAKTLDYQSPLATERYTQPELLDYSQQLIREARKLSAPQIASLMSISDKLADLNATRFHEWHPDFTPANARQAIL 81
Cdd:COG3022    1 LILLSPAKTKDFGSPLDLDELTFPELLEEREELIDALRKLSADELAKLMGISDKLAELNVERFQDWNAPLTTAPARPAIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560  82 AFKGDVYTGLQAEDFSEADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENAKGKDLYHFWGDIITDKLNAALra 161
Cdd:COG3022   81 AYTGVVYDGLDAASLSEEALAYAQEHLRILSGLYGLLRPLDLIPPYRLEMGTKLPGLRGKNLYAFWGDRLTDALNEEL-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560 162 qGDNVVINLASDEYYKSVKPKKLDADIIKPVFLDEKNGKFKVISFYAKKARGLMSRYIIQNRLTKPEQLTAFNSEGYFFD 241
Cdd:COG3022  159 -GDELVVNLASNEYFKAVDPKALKARVITPVFKEEKNGKRKVISHYAKKARGLMARYLIENRIEDPEELKAFDREGYRFD 237
                        250
                 ....*....|...
gi 544824560 242 EEASGKGELVFKR 254
Cdd:COG3022  238 EELSTEDELVFVR 250
H2O2_YaaD pfam03883
Peroxide stress protein YaaA; YaaA is a key element of the stress response to H2O2. It acts by ...
1-238 1.07e-131

Peroxide stress protein YaaA; YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.


Pssm-ID: 461083  Cd Length: 233  Bit Score: 371.47  E-value: 1.07e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560    1 MLILISPAKTLDYQSPLATERYTQPELLDYSQQLIREARKLSAPQIASLMSISDKLADLNATRFHEWHPDFTpaNARQAI 80
Cdd:pfam03883   1 MLILLSPAKTMDFDSPSPPPELTQPLFLDEAEELIDVLKSLSPEELAKLMKISDKLAELNYERYQDFKTPAL--RTKPAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560   81 LAFKGDVYTGLQAEDFSEADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENAKGKDLYHFWGDIITDklnaALR 160
Cdd:pfam03883  79 LAYTGVVYKGLDAESLSEEDLDYAQEHLRILSGLYGLLRPLDLIQPYRLEMGTKLPNPGGKNLYAFWGDKLTD----ALA 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544824560  161 AQGDNVVINLASDEYYKSVKPKKLDADIIKPVFLDEKNGKFKVISFYAKKARGLMSRYIIQNRLTKPEQLTAFNSEGY 238
Cdd:pfam03883 155 EQDDGVLVNLASGEYFKAVDPKKLKARVITPVFKEEKNGKLKVVSFYAKKARGLMVRYIAENRIESPEDLKAFDSEGY 232
 
Name Accession Description Interval E-value
PRK02101 PRK02101
peroxide stress protein YaaA;
1-257 1.60e-155

peroxide stress protein YaaA;


Pssm-ID: 234999  Cd Length: 255  Bit Score: 432.34  E-value: 1.60e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560   1 MLILISPAKTLDYQSPLATERYTQPELLDYSQQLIREARKLSAPQIASLMSISDKLADLNATRFHEWHPDFTPANARQAI 80
Cdd:PRK02101   1 MLILISPAKTLDYDGPLDTDRLSQPELLDQSQELLDALRELSPDDLASLMKISDKLAGLNAARFQDWQPEFTTANARPAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560  81 LAFKGDVYTGLQAEDFSEADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENAKGKDLYHFWGDIITDKLNAAlr 160
Cdd:PRK02101  81 LAFTGDVYDGLDADSLSEADLDYAQQHLRILSGLYGLLRPLDLIQPYRLEMGTKLPNPRGKNLYAFWGDIITQALNEA-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560 161 AQGDNVVINLASDEYYKSVKPKKLDADIIKPVFLDEKNGKFKVISFYAKKARGLMSRYIIQNRLTKPEQLTAFNSEGYFF 240
Cdd:PRK02101 159 AQGDEVLVNLASSEYFKAVKPKKLKARVITPVFLEEKNGKYKVISFYAKKARGLMARYLIENRITTPEDLKDFNFAGYAF 238
                        250
                 ....*....|....*..
gi 544824560 241 DEEASGKGELVFKRHEQ 257
Cdd:PRK02101 239 DEELSTDDELVFVRKEQ 255
YaaA COG3022
DNA-binding protein YaaA associated with the oxidative stress response [Replication, ...
2-254 1.19e-152

DNA-binding protein YaaA associated with the oxidative stress response [Replication, recombination and repair];


Pssm-ID: 442258  Cd Length: 250  Bit Score: 424.96  E-value: 1.19e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560   2 LILISPAKTLDYQSPLATERYTQPELLDYSQQLIREARKLSAPQIASLMSISDKLADLNATRFHEWHPDFTPANARQAIL 81
Cdd:COG3022    1 LILLSPAKTKDFGSPLDLDELTFPELLEEREELIDALRKLSADELAKLMGISDKLAELNVERFQDWNAPLTTAPARPAIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560  82 AFKGDVYTGLQAEDFSEADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENAKGKDLYHFWGDIITDKLNAALra 161
Cdd:COG3022   81 AYTGVVYDGLDAASLSEEALAYAQEHLRILSGLYGLLRPLDLIPPYRLEMGTKLPGLRGKNLYAFWGDRLTDALNEEL-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560 162 qGDNVVINLASDEYYKSVKPKKLDADIIKPVFLDEKNGKFKVISFYAKKARGLMSRYIIQNRLTKPEQLTAFNSEGYFFD 241
Cdd:COG3022  159 -GDELVVNLASNEYFKAVDPKALKARVITPVFKEEKNGKRKVISHYAKKARGLMARYLIENRIEDPEELKAFDREGYRFD 237
                        250
                 ....*....|...
gi 544824560 242 EEASGKGELVFKR 254
Cdd:COG3022  238 EELSTEDELVFVR 250
H2O2_YaaD pfam03883
Peroxide stress protein YaaA; YaaA is a key element of the stress response to H2O2. It acts by ...
1-238 1.07e-131

Peroxide stress protein YaaA; YaaA is a key element of the stress response to H2O2. It acts by reducing the level of intracellular iron levels after peroxide stress, thereby attenuating the Fenton reaction and the DNA damage that this would cause. The molecular mechanism of action is not known.


Pssm-ID: 461083  Cd Length: 233  Bit Score: 371.47  E-value: 1.07e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560    1 MLILISPAKTLDYQSPLATERYTQPELLDYSQQLIREARKLSAPQIASLMSISDKLADLNATRFHEWHPDFTpaNARQAI 80
Cdd:pfam03883   1 MLILLSPAKTMDFDSPSPPPELTQPLFLDEAEELIDVLKSLSPEELAKLMKISDKLAELNYERYQDFKTPAL--RTKPAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824560   81 LAFKGDVYTGLQAEDFSEADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENAKGKDLYHFWGDIITDklnaALR 160
Cdd:pfam03883  79 LAYTGVVYKGLDAESLSEEDLDYAQEHLRILSGLYGLLRPLDLIQPYRLEMGTKLPNPGGKNLYAFWGDKLTD----ALA 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544824560  161 AQGDNVVINLASDEYYKSVKPKKLDADIIKPVFLDEKNGKFKVISFYAKKARGLMSRYIIQNRLTKPEQLTAFNSEGY 238
Cdd:pfam03883 155 EQDDGVLVNLASGEYFKAVDPKKLKARVITPVFKEEKNGKLKVVSFYAKKARGLMVRYIAENRIESPEDLKAFDSEGY 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH