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Conserved domains on  [gi|544824745|ref|WP_021240746|]
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multiple stress resistance protein BhsA [Enterobacter roggenkampii]

Protein Classification

DUF1471 domain-containing protein( domain architecture ID 28000)

DUF1471 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdgH_BhsA-like super family cl11507
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 1-85 3.57e-16

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


The actual alignment was detected with superfamily member PRK10259:

Pssm-ID: 448290  Cd Length: 86  Bit Score: 66.67  E-value: 3.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824745  1 MKNVKTLIAATVLSSLSFASFAAVQV-QSTPVDQHKVGTISASAGTNLGSLEDQLAQKAQEMGAKSYRITSVTGPNTLHG 79
Cdd:PRK10259  1 MKTINTVVAAMALSTLSFGVFAAEPVtASQAQNMNKIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNKLSG 80


                ....*.
gi 544824745 80 TAVIYK 85
Cdd:PRK10259 81 TAVIYK 86
 
Name Accession Description Interval E-value
PRK10259 PRK10259
hypothetical protein; Provisional
 1-85 3.57e-16

hypothetical protein; Provisional


Pssm-ID: 137782  Cd Length: 86  Bit Score: 66.67  E-value: 3.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824745  1 MKNVKTLIAATVLSSLSFASFAAVQV-QSTPVDQHKVGTISASAGTNLGSLEDQLAQKAQEMGAKSYRITSVTGPNTLHG 79
Cdd:PRK10259  1 MKTINTVVAAMALSTLSFGVFAAEPVtASQAQNMNKIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNKLSG 80


                ....*.
gi 544824745 80 TAVIYK 85
Cdd:PRK10259 81 TAVIYK 86
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 33-84 8.69e-16

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 64.47  E-value: 8.69e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 544824745  33 QHKVGTISASAG-TNLGSLEDQLAQKAQEMGAKSYRITSVTGP--NTLHGTAVIY 84
Cdd:pfam07338  1 LQPIGTVSVSGVfGSPSDAEAALSKKADAKGAKSYRIISADEPngGNWHGTAELY 55
stress_YhcN NF033776
peroxide/acid stress response protein YhcN;
1-85 5.32e-13

peroxide/acid stress response protein YhcN;


Pssm-ID: 411360  Cd Length: 87  Bit Score: 58.51  E-value: 5.32e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824745  1 MKNVKTLIAATVLSSLSFASFAAVQVQSTPV-DQHKVGTISASA-GTNLGSLEDQLAQKAQEMGAKSYRITSVTGPNTLH 78
Cdd:NF033776  1 MKIKTTIAALSLLSVLSFGAFAAQSVNAEQAqNLQSMGTISVSGvGGSPMDIRQALSQKADEQGASAYRVIEARNGGNWH 80


                ....*..
gi 544824745 79 GTAVIYK 85
Cdd:NF033776 81 ATAELYK 87
 
Name Accession Description Interval E-value
PRK10259 PRK10259
hypothetical protein; Provisional
 1-85 3.57e-16

hypothetical protein; Provisional


Pssm-ID: 137782  Cd Length: 86  Bit Score: 66.67  E-value: 3.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824745  1 MKNVKTLIAATVLSSLSFASFAAVQV-QSTPVDQHKVGTISASAGTNLGSLEDQLAQKAQEMGAKSYRITSVTGPNTLHG 79
Cdd:PRK10259  1 MKTINTVVAAMALSTLSFGVFAAEPVtASQAQNMNKIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNKLSG 80


                ....*.
gi 544824745 80 TAVIYK 85
Cdd:PRK10259 81 TAVIYK 86
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 33-84 8.69e-16

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 64.47  E-value: 8.69e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 544824745  33 QHKVGTISASAG-TNLGSLEDQLAQKAQEMGAKSYRITSVTGP--NTLHGTAVIY 84
Cdd:pfam07338  1 LQPIGTVSVSGVfGSPSDAEAALSKKADAKGAKSYRIISADEPngGNWHGTAELY 55
stress_YhcN NF033776
peroxide/acid stress response protein YhcN;
1-85 5.32e-13

peroxide/acid stress response protein YhcN;


Pssm-ID: 411360  Cd Length: 87  Bit Score: 58.51  E-value: 5.32e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824745  1 MKNVKTLIAATVLSSLSFASFAAVQVQSTPV-DQHKVGTISASA-GTNLGSLEDQLAQKAQEMGAKSYRITSVTGPNTLH 78
Cdd:NF033776  1 MKIKTTIAALSLLSVLSFGAFAAQSVNAEQAqNLQSMGTISVSGvGGSPMDIRQALSQKADEQGASAYRVIEARNGGNWH 80


                ....*..
gi 544824745 79 GTAVIYK 85
Cdd:NF033776 81 ATAELYK 87
PRK09929 PRK09929
hypothetical protein; Provisional
 1-85 1.73e-06

hypothetical protein; Provisional


Pssm-ID: 182151  Cd Length: 91  Bit Score: 41.82  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824745  1 MKNVKTLIAATvLSSLSFASFAA-----VQVQSTPVDQHKVGTISASAGTNLGSLEDQLAQKAQEMGAKSYRITSVTGPN 75
Cdd:PRK09929  1 MKIISKMLLGA-LAFAVTNVYAAelmtkAEFEKVESQYEKIGTISTSNEMSTADAKEDLIKKADEKGADVLVLTSGQTDN 79

                        90
                ....*....|
gi 544824745 76 TLHGTAVIYK 85
Cdd:PRK09929 80 KIHGTADIYK 89
PRK14864 PRK14864
biofilm peroxide resistance protein BsmA;
1-85 1.68e-04

biofilm peroxide resistance protein BsmA;


Pssm-ID: 184866  Cd Length: 104  Bit Score: 36.94  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544824745   1 MKNVKTLIAATVLSSLSfaSFAAVQVQSTPVDQH-------------KVGTISASAGTNLGSLEDQLAQKAQEMGAKSYR 67
Cdd:PRK14864   5 MRRFASLLLTLLLSACS--ALQGTPQPAPPPADHaqeirraqtqglqKMGTVSALVRGSPDDAEREIQAKANAAGADYYV 82

                         90       100
                 ....*....|....*....|.
gi 544824745  68 ITSV---TGPNTLHGTAVIYK 85
Cdd:PRK14864  83 IVMVdetVVPGQWYSQAILYR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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